Refine
Has Fulltext
- no (72)
Year of publication
Language
- English (72)
Is part of the Bibliography
- yes (72)
Keywords
- gamma rays: general (24)
- radiation mechanisms: non-thermal (20)
- ISM: supernova remnants (14)
- gamma rays: galaxies (13)
- galaxies: active (12)
- cosmic rays (11)
- acceleration of particles (8)
- ISM: clouds (6)
- astroparticle physics (6)
- gamma rays: ISM (6)
- gamma rays: stars (6)
- galaxies: jets (5)
- gamma-rays: galaxies (5)
- X-rays: binaries (4)
- BL Lacertae objects: individual: PKS 2155-304 (3)
- pulsars: general (3)
- BL Lacertae objects: general (2)
- ISM: individual objects: G338.3-0.0 (2)
- binaries: general (2)
- errata, addenda (2)
- galaxies: nuclei (2)
- infrared: diffuse background (2)
- pulsars: individual: PSR B0833-45 (2)
- relativistic processes (2)
- stars: massive (2)
- surveys (2)
- Air showers (1)
- BL Lacertae objects: individual (Mrk 501) (1)
- BL Lacertae objects: individual (PG 1553+113) (1)
- BL Lacertae objects: individual: 1ES 1312-423 (1)
- BL Lacertae objects: individual: 1ES 2322-409 (1)
- BL Lacertae objects: individual: AP Librae (1)
- BL Lacertae objects: individual: PKS 0301-243 (1)
- BL Lacertae objects: individual: PKS 0447-439 (1)
- BL Lacertae objects: individual: SHBL J001355.9-185406 (1)
- BL Lacertae objects: individual: lES 0229+200 (1)
- BL Lacertae objects: individual: lES 1101-232 (1)
- Cherenkov Telescopes (1)
- Galaxy: center (1)
- Galaxy: general (1)
- ISM (1)
- ISM: individual objects (RX J1713.7-3946, G347.3-0.5) (1)
- ISM: individual objects (SNR G338.3-0.0, SNR G338.5+0.1) (1)
- ISM: individual objects: Crab nebula (1)
- ISM: individual objects: HESS J1832-093 (1)
- ISM: individual objects: Puppis A (1)
- ISM: individual objects: SNR G1.9+0.3 (1)
- ISM: individual objects: SNR G22.7-0.2 (1)
- ISM: individual objects: SNR G330.2+1.0 (1)
- ISM: jets and outflows (1)
- ISM: magnetic fields (1)
- TeV gamma-ray astronomy (1)
- X-rays: general (1)
- X-rays: individuals: Circinus X-1 (1)
- X-rays: individuals: G15.4+0.1 (1)
- X-rays: individuals: GRS 1915+105 (1)
- X-rays: individuals: V4641 Sgr (1)
- X-rays: stars (1)
- astroparticle physic (1)
- black hole physics (1)
- catalogs (1)
- convection (1)
- cosmic background radiation (1)
- dark matter detectors (1)
- dark matter experiments (1)
- diffuse radiation (1)
- diffusion (1)
- dwarfs galaxies (1)
- galaxies: distances and redshifts (1)
- galaxies: individual (M 87) (1)
- galaxies: individual: PKS 0625-354 (1)
- galaxies: magnetic fields (1)
- galaxies: starburst (1)
- gamma ray detectors (1)
- gamma rays: (1)
- gamma rays: general(HESS J0632+057, VER J0633+057) (1)
- gamma-ray burst: individual (GRB 170817A) (1)
- gamma-ray burst: individual: GRB 100621A (1)
- gamma-rays: ISM (1)
- gamma-rays: general (1)
- globular clusters: general (1)
- gravitational lensing: strong (1)
- gravitational waves (1)
- intergalactic medium (1)
- methods: observational (1)
- pulsars: individual: PSR B1259-63 (1)
- quasars: individual: 3C 279 (1)
- quasars: individual: PKS 1510-089 (1)
- stars: black holes (1)
- stars: early-type (1)
- stars: individual: 1FGL J1018.6-5856 (1)
- stars: individual: LS 2883 (1)
- stars: magnetars (1)
- stars: winds, outflows (1)
- supernovae: general (1)
- supernovae: individual: HESS J1818-154 (1)
Institute
KEPI is a protein kinase C-potentiated inhibitory protein for type 1 Ser/Thr protein phosphatases. We found no or reduced expression of KEPI in breast cancer cell lines, breast tumors and metastases in comparison to normal breast cell lines and tissues, respectively. KEPI protein expression and ubiquitous localization was detected with a newly generated antibody. Ectopic KEPI expression in MCF7 breast cancer cells induced differential expression of 95 genes, including the up-regulation of the tumor suppressors EGR1 (early growth response 1) and PTEN (phosphatase and tensin homolog), which is regulated by EGR1. We further show that the up-regulation of EGR1 in MCF7/KEPI cells is mediated by MEK-ERK signaling. The inhibition of this pathway by the MEK inhibitor UO126 led to a strong decrease in EGR1 expression in MCF7/KEPI cells. These results reveal a novel role for KEPI in the regulation of the tumor suppressor gene EGR1 via activation of the MEK-ERK MAPK pathway.