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Keywords
Prospects for Cherenkov Telescope Array Observations of the Young Supernova Remnant RX J1713.7-3946
(2017)
Acero, F. ; Aloisio, R. ; Amans, J. ; Amato, Elena ; Antonelli, L. A. ; Aramo, C. ; Armstrong, T. ; Arqueros, F. ; Asano, Katsuaki ; Ashley, M. ; Backes, M. ; Balazs, C. ; Balzer, A. ; Bamba, Aya ; Barkov, Maxim ; Barrio, J. A. ; Benbow, Wystan ; Bernloehr, K. ; Beshley, V. ; Bigongiari, C. ; Biland, A. ; Bilinsky, A. ; Bissaldi, Elisabetta ; Biteau, J. ; Blanch, O. ; Blasi, P. ; Blazek, J. ; Boisson, C. ; Bonanno, G. ; Bonardi, A. ; Bonavolonta, C. ; Bonnoli, G. ; Braiding, C. ; Brau-Nogue, S. ; Bregeon, J. ; Brown, A. M. ; Bugaev, V. ; Bulgarelli, A. ; Bulik, T. ; Burton, Michael ; Burtovoi, A. ; Busetto, G. ; Bottcher, M. ; Cameron, R. ; Capalbi, M. ; Caproni, Anderson ; Caraveo, P. ; Carosi, R. ; Cascone, E. ; Cerruti, M. ; Chaty, Sylvain ; Chen, A. ; Chen, X. ; Chernyakova, M. ; Chikawa, M. ; Chudoba, J. ; Cohen-Tanugi, J. ; Colafrancesco, S. ; Conforti, V. ; Contreras, J. L. ; Costa, A. ; Cotter, G. ; Covino, Stefano ; Covone, G. ; Cumani, P. ; Cusumano, G. ; Daniel, M. ; Dazzi, F. ; De Angelis, A. ; De Cesare, G. ; De Franco, A. ; De Frondat, F. ; Dal Pino, E. M. de Gouveia ; De Lisio, C. ; Lopez, R. de los Reyes ; De Lotto, B. ; de Naurois, M. ; De Palma, F. ; Del Santo, M. ; Delgado, C. ; della Volpe, D. ; Di Girolamo, T. ; Di Giulio, C. ; Di Pierro, F. ; Di Venere, L. ; Doro, M. ; Dournaux, J. ; Dumas, D. ; Dwarkadas, Vikram V. ; Diaz, C. ; Ebr, J. ; Egberts, Kathrin ; Einecke, S. ; Elsaesser, D. ; Eschbach, S. ; Falceta-Goncalves, D. ; Fasola, G. ; Fedorova, E. ; Fernandez-Barral, A. ; Ferrand, Gilles ; Fesquet, M. ; Fiandrini, E. ; Fiasson, A. ; Filipovic, Miroslav D. ; Fioretti, V. ; Font, L. ; Fontaine, Gilles ; Franco, F. J. ; Freixas Coromina, L. ; Fujita, Yutaka ; Fukui, Y. ; Funk, S. ; Forster, A. ; Gadola, A. ; Lopez, R. Garcia ; Garczarczyk, M. ; Giglietto, N. ; Giordano, F. ; Giuliani, A. ; Glicenstein, J. ; Gnatyk, R. ; Goldoni, P. ; Grabarczyk, T. ; Graciani, R. ; Graham, J. ; Grandi, P. ; Granot, Jonathan ; Green, A. J. ; Griffiths, S. ; Gunji, S. ; Hakobyan, H. ; Hara, S. ; Hassan, T. ; Hayashida, M. ; Heller, M. ; Helo, J. C. ; Hinton, J. ; Hnatyk, B. ; Huet, J. ; Huetten, M. ; Humensky, T. B. ; Hussein, M. ; Horandel, J. ; Ikeno, Y. ; Inada, T. ; Inome, Y. ; Inoue, S. ; Inoue, T. ; Inoue, Y. ; Ioka, K. ; Iori, Maurizio ; Jacquemier, J. ; Janecek, P. ; Jankowsky, D. ; Jung, I. ; Kaaret, P. ; Katagiri, H. ; Kimeswenger, S. ; Kimura, Shigeo S. ; Knodlseder, J. ; Koch, B. ; Kocot, J. ; Kohri, K. ; Komin, N. ; Konno, Y. ; Kosack, K. ; Koyama, S. ; Kraus, Michaela ; Kubo, Hidetoshi ; Mezek, G. Kukec ; Kushida, J. ; La Palombara, N. ; Lalik, K. ; Lamanna, G. ; Landt, H. ; Lapington, J. ; Laporte, P. ; Lee, S. ; Lees, J. ; Lefaucheur, J. ; Lenain, J. -P. ; Leto, Giuseppe ; Lindfors, E. ; Lohse, T. ; Lombardi, S. ; Longo, F. ; Lopez, M. ; Lucarelli, F. ; Luque-Escamilla, Pedro Luis ; Lopez-Coto, R. ; Maccarone, M. C. ; Maier, G. ; Malaguti, G. ; Mandat, D. ; Maneva, G. ; Mangano, S. ; Marcowith, Alexandre ; Marti, J. ; Martinez, M. ; Martinez, G. ; Masuda, S. ; Maurin, G. ; Maxted, N. ; Melioli, Claudio ; Mineo, T. ; Mirabal, N. ; Mizuno, T. ; Moderski, R. ; Mohammed, M. ; Montaruli, T. ; Moralejo, A. ; Mori, K. ; Morlino, G. ; Morselli, A. ; Moulin, Emmanuel ; Mukherjee, R. ; Mundell, C. ; Muraishi, H. ; Murase, Kohta ; Nagataki, Shigehiro ; Nagayoshi, T. ; Naito, T. ; Nakajima, D. ; Nakamori, T. ; Nemmen, R. ; Niemiec, Jacek ; Nieto, D. ; Nievas-Rosillo, M. ; Nikolajuk, M. ; Nishijima, K. ; Noda, K. ; Nogues, L. ; Nosek, D. ; Novosyadlyj, B. ; Nozaki, S. ; Ohira, Yutaka ; Ohishi, M. ; Ohm, S. ; Okumura, A. ; Ong, R. A. ; Orito, R. ; Orlati, A. ; Ostrowski, M. ; Oya, I. ; Padovani, Marco ; Palacio, J. ; Palatka, M. ; Paredes, Josep M. ; Pavy, S. ; Persic, M. ; Petrucci, P. ; Petruk, Oleh ; Pisarski, A. ; Pohl, Martin ; Porcelli, A. ; Prandini, E. ; Prast, J. ; Principe, G. ; Prouza, M. ; Pueschel, Elisa ; Puelhofer, G. ; Quirrenbach, A. ; Rameez, M. ; Reimer, O. ; Renaud, M. ; Ribo, M. ; Rico, J. ; Rizi, V. ; Rodriguez, J. ; Fernandez, G. Rodriguez ; Rodriguez Vazquez, J. J. ; Romano, Patrizia ; Romeo, G. ; Rosado, J. ; Rousselle, J. ; Rowell, G. ; Rudak, B. ; Sadeh, I. ; Safi-Harb, S. ; Saito, T. ; Sakaki, N. ; Sanchez, D. ; Sangiorgi, P. ; Sano, H. ; Santander, M. ; Sarkar, S. ; Sawada, M. ; Schioppa, E. J. ; Schoorlemmer, H. ; Schovanek, P. ; Schussler, F. ; Sergijenko, O. ; Servillat, M. ; Shalchi, A. ; Shellard, R. C. ; Siejkowski, H. ; Sillanpaa, A. ; Simone, D. ; Sliusar, V. ; Sol, H. ; Stanic, S. ; Starling, R. ; Stawarz, L. ; Stefanik, S. ; Stephan, M. ; Stolarczyk, T. ; Szanecki, M. ; Szepieniec, T. ; Tagliaferri, G. ; Tajima, H. ; Takahashi, M. ; Takeda, J. ; Tanaka, M. ; Tanaka, S. ; Tejedor, L. A. ; Telezhinsky, Igor O. ; Temnikov, P. ; Terada, Y. ; Tescaro, D. ; Teshima, M. ; Testa, V. ; Thoudam, S. ; Tokanai, F. ; Torres, D. F. ; Torresi, E. ; Tosti, G. ; Townsley, C. ; Travnicek, P. ; Trichard, C. ; Trifoglio, M. ; Tsujimoto, S. ; Vagelli, V. ; Vallania, P. ; Valore, L. ; van Driel, W. ; van Eldik, C. ; Vandenbroucke, Justin ; Vassiliev, V. ; Vecchi, M. ; Vercellone, Stefano ; Vergani, S. ; Vigorito, C. ; Vorobiov, S. ; Vrastil, M. ; Vazquez Acosta, M. L. ; Wagner, S. J. ; Wagner, R. ; Wakely, S. P. ; Walter, R. ; Ward, J. E. ; Watson, J. J. ; Weinstein, A. ; White, M. ; White, R. ; Wierzcholska, A. ; Wilcox, P. ; Williams, D. A. ; Wischnewski, R. ; Wojcik, P. ; Yamamoto, T. ; Yamamoto, H. ; Yamazaki, Ryo ; Yanagita, S. ; Yang, L. ; Yoshida, T. ; Yoshida, M. ; Yoshiike, S. ; Yoshikoshi, T. ; Zacharias, M. ; Zampieri, L. ; Zanin, R. ; Zavrtanik, M. ; Zavrtanik, D. ; Zdziarski, A. ; Zech, Alraune ; Zechlin, Hannes ; Zhdanov, V. ; Ziegler, A. ; Zorn, J.
We perform simulations for future Cherenkov Telescope Array (CTA) observations of RX J1713.7-3946, a young supernova remnant (SNR) and one of the brightest sources ever discovered in very high energy (VHE) gamma rays. Special attention is paid to exploring possible spatial (anti) correlations of gamma rays with emission at other wavelengths, in particular X-rays and CO/H I emission. We present a series of simulated images of RX J1713.7-3946 for CTA based on a set of observationally motivated models for the gamma-ray emission. In these models, VHE gamma rays produced by high-energy electrons are assumed to trace the nonthermal X-ray emission observed by XMM-Newton, whereas those originating from relativistic protons delineate the local gas distributions. The local atomic and molecular gas distributions are deduced by the NANTEN team from CO and H I observations. Our primary goal is to show how one can distinguish the emission mechanism(s) of the gamma rays (i.e., hadronic versus leptonic, or a mixture of the two) through information provided by their spatial distribution, spectra, and time variation. This work is the first attempt to quantitatively evaluate the capabilities of CTA to achieve various proposed scientific goals by observing this important cosmic particle accelerator.
A catalog of genetic loci associated with kidney function from analyses of a million individuals
(2019)
Wuttke, Matthias ; Li, Yong ; Li, Man ; Sieber, Karsten B. ; Feitosa, Mary F. ; Gorski, Mathias ; Tin, Adrienne ; Wang, Lihua ; Chu, Audrey Y. ; Hoppmann, Anselm ; Kirsten, Holger ; Giri, Ayush ; Chai, Jin-Fang ; Sveinbjornsson, Gardar ; Tayo, Bamidele O. ; Nutile, Teresa ; Fuchsberger, Christian ; Marten, Jonathan ; Cocca, Massimiliano ; Ghasemi, Sahar ; Xu, Yizhe ; Horn, Katrin ; Noce, Damia ; Van der Most, Peter J. ; Sedaghat, Sanaz ; Yu, Zhi ; Akiyama, Masato ; Afaq, Saima ; Ahluwalia, Tarunveer Singh ; Almgren, Peter ; Amin, Najaf ; Arnlov, Johan ; Bakker, Stephan J. L. ; Bansal, Nisha ; Baptista, Daniela ; Bergmann, Sven ; Biggs, Mary L. ; Biino, Ginevra ; Boehnke, Michael ; Boerwinkle, Eric ; Boissel, Mathilde ; Böttinger, Erwin ; Boutin, Thibaud S. ; Brenner, Hermann ; Brumat, Marco ; Burkhardt, Ralph ; Butterworth, Adam S. ; Campana, Eric ; Campbell, Archie ; Campbell, Harry ; Canouil, Mickael ; Carroll, Robert J. ; Catamo, Eulalia ; Chambers, John C. ; Chee, Miao-Ling ; Chee, Miao-Li ; Chen, Xu ; Cheng, Ching-Yu ; Cheng, Yurong ; Christensen, Kaare ; Cifkova, Renata ; Ciullo, Marina ; Concas, Maria Pina ; Cook, James P. ; Coresh, Josef ; Corre, Tanguy ; Sala, Cinzia Felicita ; Cusi, Daniele ; Danesh, John ; Daw, E. Warwick ; De Borst, Martin H. ; De Grandi, Alessandro ; De Mutsert, Renee ; De Vries, Aiko P. J. ; Degenhardt, Frauke ; Delgado, Graciela ; Demirkan, Ayse ; Di Angelantonio, Emanuele ; Dittrich, Katalin ; Divers, Jasmin ; Dorajoo, Rajkumar ; Eckardt, Kai-Uwe ; Ehret, Georg ; Elliott, Paul ; Endlich, Karlhans ; Evans, Michele K. ; Felix, Janine F. ; Foo, Valencia Hui Xian ; Franco, Oscar H. ; Franke, Andre ; Freedman, Barry I. ; Freitag-Wolf, Sandra ; Friedlander, Yechiel ; Froguel, Philippe ; Gansevoort, Ron T. ; Gao, He ; Gasparini, Paolo ; Gaziano, J. Michael ; Giedraitis, Vilmantas ; Gieger, Christian ; Girotto, Giorgia ; Giulianini, Franco ; Gogele, Martin ; Gordon, Scott D. ; Gudbjartsson, Daniel F. ; Gudnason, Vilmundur ; Haller, Toomas ; Hamet, Pavel ; Harris, Tamara B. ; Hartman, Catharina A. ; Hayward, Caroline ; Hellwege, Jacklyn N. ; Heng, Chew-Kiat ; Hicks, Andrew A. ; Hofer, Edith ; Huang, Wei ; Hutri-Kahonen, Nina ; Hwang, Shih-Jen ; Ikram, M. Arfan ; Indridason, Olafur S. ; Ingelsson, Erik ; Ising, Marcus ; Jaddoe, Vincent W. V. ; Jakobsdottir, Johanna ; Jonas, Jost B. ; Joshi, Peter K. ; Josyula, Navya Shilpa ; Jung, Bettina ; Kahonen, Mika ; Kamatani, Yoichiro ; Kammerer, Candace M. ; Kanai, Masahiro ; Kastarinen, Mika ; Kerr, Shona M. ; Khor, Chiea-Chuen ; Kiess, Wieland ; Kleber, Marcus E. ; Koenig, Wolfgang ; Kooner, Jaspal S. ; Korner, Antje ; Kovacs, Peter ; Kraja, Aldi T. ; Krajcoviechova, Alena ; Kramer, Holly ; Kramer, Bernhard K. ; Kronenberg, Florian ; Kubo, Michiaki ; Kuhnel, Brigitte ; Kuokkanen, Mikko ; Kuusisto, Johanna ; La Bianca, Martina ; Laakso, Markku ; Lange, Leslie A. ; Langefeld, Carl D. ; Lee, Jeannette Jen-Mai ; Lehne, Benjamin ; Lehtimaki, Terho ; Lieb, Wolfgang ; Lim, Su-Chi ; Lind, Lars ; Lindgren, Cecilia M. ; Liu, Jun ; Liu, Jianjun ; Loeffler, Markus ; Loos, Ruth J. F. ; Lucae, Susanne ; Lukas, Mary Ann ; Lyytikainen, Leo-Pekka ; Magi, Reedik ; Magnusson, Patrik K. E. ; Mahajan, Anubha ; Martin, Nicholas G. ; Martins, Jade ; Marz, Winfried ; Mascalzoni, Deborah ; Matsuda, Koichi ; Meisinger, Christa ; Meitinger, Thomas ; Melander, Olle ; Metspalu, Andres ; Mikaelsdottir, Evgenia K. ; Milaneschi, Yuri ; Miliku, Kozeta ; Mishra, Pashupati P. ; Program, V. A. Million Veteran ; Mohlke, Karen L. ; Mononen, Nina ; Montgomery, Grant W. ; Mook-Kanamori, Dennis O. ; Mychaleckyj, Josyf C. ; Nadkarni, Girish N. ; Nalls, Mike A. ; Nauck, Matthias ; Nikus, Kjell ; Ning, Boting ; Nolte, Ilja M. ; Noordam, Raymond ; Olafsson, Isleifur ; Oldehinkel, Albertine J. ; Orho-Melander, Marju ; Ouwehand, Willem H. ; Padmanabhan, Sandosh ; Palmer, Nicholette D. ; Palsson, Runolfur ; Penninx, Brenda W. J. H. ; Perls, Thomas ; Perola, Markus ; Pirastu, Mario ; Pirastu, Nicola ; Pistis, Giorgio ; Podgornaia, Anna I. ; Polasek, Ozren ; Ponte, Belen ; Porteous, David J. ; Poulain, Tanja ; Pramstaller, Peter P. ; Preuss, Michael H. ; Prins, Bram P. ; Province, Michael A. ; Rabelink, Ton J. ; Raffield, Laura M. ; Raitakari, Olli T. ; Reilly, Dermot F. ; Rettig, Rainer ; Rheinberger, Myriam ; Rice, Kenneth M. ; Ridker, Paul M. ; Rivadeneira, Fernando ; Rizzi, Federica ; Roberts, David J. ; Robino, Antonietta ; Rossing, Peter ; Rudan, Igor ; Rueedi, Rico ; Ruggiero, Daniela ; Ryan, Kathleen A. ; Saba, Yasaman ; Sabanayagam, Charumathi ; Salomaa, Veikko ; Salvi, Erika ; Saum, Kai-Uwe ; Schmidt, Helena ; Schmidt, Reinhold ; Ben Schottker ; Schulz, Christina-Alexandra ; Schupf, Nicole ; Shaffer, Christian M. ; Shi, Yuan ; Smith, Albert V. ; Smith, Blair H. ; Soranzo, Nicole ; Spracklen, Cassandra N. ; Strauch, Konstantin ; Stringham, Heather M. ; Stumvoll, Michael ; Svensson, Per O. ; Szymczak, Silke ; Tai, E-Shyong ; Tajuddin, Salman M. ; Tan, Nicholas Y. Q. ; Taylor, Kent D. ; Teren, Andrej ; Tham, Yih-Chung ; Thiery, Joachim ; Thio, Chris H. L. ; Thomsen, Hauke ; Thorleifsson, Gudmar ; Toniolo, Daniela ; Tonjes, Anke ; Tremblay, Johanne ; Tzoulaki, Ioanna ; Uitterlinden, Andre G. ; Vaccargiu, Simona ; Van Dam, Rob M. ; Van der Harst, Pim ; Van Duijn, Cornelia M. ; Edward, Digna R. Velez ; Verweij, Niek ; Vogelezang, Suzanne ; Volker, Uwe ; Vollenweider, Peter ; Waeber, Gerard ; Waldenberger, Melanie ; Wallentin, Lars ; Wang, Ya Xing ; Wang, Chaolong ; Waterworth, Dawn M. ; Bin Wei, Wen ; White, Harvey ; Whitfield, John B. ; Wild, Sarah H. ; Wilson, James F. ; Wojczynski, Mary K. ; Wong, Charlene ; Wong, Tien-Yin ; Xu, Liang ; Yang, Qiong ; Yasuda, Masayuki ; Yerges-Armstrong, Laura M. ; Zhang, Weihua ; Zonderman, Alan B. ; Rotter, Jerome I. ; Bochud, Murielle ; Psaty, Bruce M. ; Vitart, Veronique ; Wilson, James G. ; Dehghan, Abbas ; Parsa, Afshin ; Chasman, Daniel I. ; Ho, Kevin ; Morris, Andrew P. ; Devuyst, Olivier ; Akilesh, Shreeram ; Pendergrass, Sarah A. ; Sim, Xueling ; Boger, Carsten A. ; Okada, Yukinori ; Edwards, Todd L. ; Snieder, Harold ; Stefansson, Kari ; Hung, Adriana M. ; Heid, Iris M. ; Scholz, Markus ; Teumer, Alexander ; Kottgen, Anna ; Pattaro, Cristian
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
Acharya, B. S. ; Aramo, C. ; Babic, A. ; Barrio, J. A. ; Baushev, Anton N. ; Tjus, J. Becker ; Berge, David ; Bohacova, M. ; Bonardi, A. ; Brown, A. ; Bugaev, V. ; Bulik, Tomasz ; Burton, M. ; Busetto, G. ; Caraveo, P. A. ; Carosi, R. ; Carr, John ; Chadwick, Paula M. ; Chudoba, J. ; Conforti, V. ; Connaughton, V. ; Contreras, J. L. ; Cotter, G. ; Dazzi, F. ; De Franco, A. ; de la Calle, I. ; Lopez, R. de los Reyes ; De Lotto, B. ; De Palma, F. ; Di Girolamo, T. ; Di Giulio, C. ; Di Pierro, F. ; Dournaux, J. -L. ; Dwarkadas, Vikram V. ; Ebr, J. ; Egberts, Kathrin ; Fesquet, M. ; Fleischhack, H. ; Font, L. ; Fontaine, G. ; Foerster, A. ; Füßling, Matthias ; Garcia, B. ; Lopez, R. Garcia ; Garczarczyk, M. ; Gargano, F. ; Garrido, D. ; Gaug, M. ; Giglietto, N. ; Giordano, F. ; Giuliani, A. ; Godinovic, N. ; Gonzalez, M. M. ; Grabarczyk, T. ; Hassan, T. ; Hoerandel, J. ; Hrabovsky, M. ; Hrupec, D. ; Humensky, T. B. ; Huovelin, J. ; Jamrozy, M. ; Janecek, P. ; Kaaret, P. E. ; Katz, U. ; Kaufmann, S. ; Khelifi, B. ; Kluzniak, W. ; Kocot, J. ; Komin, N. ; Kubo, H. ; Kushida, J. ; Lamanna, G. ; Lee, W. H. ; Lenain, J. -P. ; Lohse, T. ; Lombardi, S. ; Lopez-Coto, R. ; Lopez-Oramas, A. ; Lucarelli, F. ; Maccarone, M. C. ; Maier, G. ; Majumdar, P. ; Malaguti, G. ; Mandat, D. ; Mazziotta, Mario Nicola ; Meagher, K. ; Mirabal, N. ; Morselli, A. ; Moulin, Emmanuel ; Niemiec, J. ; Nievas, M. ; Nishijima, K. ; Nosek, D. ; Nunio, F. ; Ohishi, M. ; Ohm, S. ; Ong, R. A. ; Orito, R. ; Otte, N. ; Palatka, M. ; Pareschi, G. ; Pech, M. ; Persic, M. ; Pohl, Manuela ; Prouza, M. ; Quirrenbach, A. ; Raino, S. ; Fernandez, G. Rodriguez ; Romano, Patrizia ; Rovero, A. C. ; Rudak, B. ; Schovanek, P. ; Shayduk, M. ; Siejkowski, H. ; Sillanpaa, A. ; Stefanik, S. ; Stolarczyk, T. ; Szanecki, M. ; Szepieniec, T. ; Tejedor, L. A. ; Telezhinsky, Igor O. ; Teshima, M. ; Tibaldo, L. ; Tibolla, O. ; Tovmassian, G. ; Travnicek, P. ; Trzeciak, M. ; Vallania, P. ; van Eldik, C. ; Vercellone, S. ; Vigorito, C. ; Wagner, S. J. ; Wakely, S. P. ; Weinstein, A. ; Wierzcholska, A. ; Wilhelm, Alina ; Wojcik, P. ; Yoshikoshi, T.
Supernova remnants (SNRs) are among the most important targets for gamma-ray observatories. Being prominent non-thermal sources, they are very likely responsible for the acceleration of the bulk of Galactic cosmic rays (CRS). To firmly establish the SNR paradigm for the origin of cosmic rays, it should be confirmed that protons are indeed accelerated in, and released from, SNRs with the appropriate flux and spectrum. This can be done by detailed theoretical models which account for microphysics of acceleration and various radiation processes of hadrons and leptons. The current generation of Cherenkov telescopes has insufficient sensitivity to constrain theoretical models. A new facility, the Cherenkov Telescope Array (CTA), will have superior capabilities and may finally resolve this long standing issue of high-energy astrophysics. We want to assess the capabilities of CTA to reveal the physics of various types of SNRs in the initial 2000 years of their evolution. During this time, the efficiency to accelerate cosmic rays is highest. We perform time-dependent simulations of the hydrodynamics, the magnetic fields, the cosmic-ray acceleration, and the non-thermal emission for type Ia, Ic and IIP SNRs. We calculate the CTA response to the y-ray emission from these SNRs for various ages and distances, and we perform a realistic analysis of the simulated data. We derive distance limits for the detectability and resolvability of these SNR types at several ages. We test the ability of CTA to reconstruct their morphological and spectral parameters as a function of their distance. Finally, we estimate how well CTA data will constrain the theoretical models. (C) 2014 Elsevier B.V. All rights reserved.
Tiegs, Scott D. ; Costello, David M. ; Isken, Mark W. ; Woodward, Guy ; McIntyre, Peter B. ; Gessner, Mark O. ; Chauvet, Eric ; Griffiths, Natalie A. ; Flecker, Alex S. ; Acuna, Vicenc ; Albarino, Ricardo ; Allen, Daniel C. ; Alonso, Cecilia ; Andino, Patricio ; Arango, Clay ; Aroviita, Jukka ; Barbosa, Marcus V. M. ; Barmuta, Leon A. ; Baxter, Colden V. ; Bell, Thomas D. C. ; Bellinger, Brent ; Boyero, Luz ; Brown, Lee E. ; Bruder, Andreas ; Bruesewitz, Denise A. ; Burdon, Francis J. ; Callisto, Marcos ; Canhoto, Cristina ; Capps, Krista A. ; Castillo, Maria M. ; Clapcott, Joanne ; Colas, Fanny ; Colon-Gaud, Checo ; Cornut, Julien ; Crespo-Perez, Veronica ; Cross, Wyatt F. ; Culp, Joseph M. ; Danger, Michael ; Dangles, Olivier ; de Eyto, Elvira ; Derry, Alison M. ; Diaz Villanueva, Veronica ; Douglas, Michael M. ; Elosegi, Arturo ; Encalada, Andrea C. ; Entrekin, Sally ; Espinosa, Rodrigo ; Ethaiya, Diana ; Ferreira, Veronica ; Ferriol, Carmen ; Flanagan, Kyla M. ; Fleituch, Tadeusz ; Shah, Jennifer J. Follstad ; Frainer, Andre ; Friberg, Nikolai ; Frost, Paul C. ; Garcia, Erica A. ; Lago, Liliana Garcia ; Garcia Soto, Pavel Ernesto ; Ghate, Sudeep ; Giling, Darren P. ; Gilmer, Alan ; Goncalves, Jose Francisco ; Gonzales, Rosario Karina ; Graca, Manuel A. S. ; Grace, Mike ; Grossart, Hans-Peter ; Guerold, Francois ; Gulis, Vlad ; Hepp, Luiz U. ; Higgins, Scott ; Hishi, Takuo ; Huddart, Joseph ; Hudson, John ; Imberger, Samantha ; Iniguez-Armijos, Carlos ; Iwata, Tomoya ; Janetski, David J. ; Jennings, Eleanor ; Kirkwood, Andrea E. ; Koning, Aaron A. ; Kosten, Sarian ; Kuehn, Kevin A. ; Laudon, Hjalmar ; Leavitt, Peter R. ; Lemes da Silva, Aurea L. ; Leroux, Shawn J. ; Leroy, Carri J. ; Lisi, Peter J. ; MacKenzie, Richard ; Marcarelli, Amy M. ; Masese, Frank O. ; Mckie, Brendan G. ; Oliveira Medeiros, Adriana ; Meissner, Kristian ; Milisa, Marko ; Mishra, Shailendra ; Miyake, Yo ; Moerke, Ashley ; Mombrikotb, Shorok ; Mooney, Rob ; Moulton, Tim ; Muotka, Timo ; Negishi, Junjiro N. ; Neres-Lima, Vinicius ; Nieminen, Mika L. ; Nimptsch, Jorge ; Ondruch, Jakub ; Paavola, Riku ; Pardo, Isabel ; Patrick, Christopher J. ; Peeters, Edwin T. H. M. ; Pozo, Jesus ; Pringle, Catherine ; Prussian, Aaron ; Quenta, Estefania ; Quesada, Antonio ; Reid, Brian ; Richardson, John S. ; Rigosi, Anna ; Rincon, Jose ; Risnoveanu, Geta ; Robinson, Christopher T. ; Rodriguez-Gallego, Lorena ; Royer, Todd V. ; Rusak, James A. ; Santamans, Anna C. ; Selmeczy, Geza B. ; Simiyu, Gelas ; Skuja, Agnija ; Smykla, Jerzy ; Sridhar, Kandikere R. ; Sponseller, Ryan ; Stoler, Aaron ; Swan, Christopher M. ; Szlag, David ; Teixeira-de Mello, Franco ; Tonkin, Jonathan D. ; Uusheimo, Sari ; Veach, Allison M. ; Vilbaste, Sirje ; Vought, Lena B. M. ; Wang, Chiao-Ping ; Webster, Jackson R. ; Wilson, Paul B. ; Woelfl, Stefan ; Xenopoulos, Marguerite A. ; Yates, Adam G. ; Yoshimura, Chihiro ; Yule, Catherine M. ; Zhang, Yixin X. ; Zwart, Jacob A.
River ecosystems receive and process vast quantities of terrestrial organic carbon, the fate of which depends strongly on microbial activity. Variation in and controls of processing rates, however, are poorly characterized at the global scale. In response, we used a peer-sourced research network and a highly standardized carbon processing assay to conduct a global-scale field experiment in greater than 1000 river and riparian sites. We found that Earth’s biomes have distinct carbon processing signatures. Slow processing is evident across latitudes, whereas rapid rates are restricted to lower latitudes. Both the mean rate and variability decline with latitude, suggesting temperature constraints toward the poles and greater roles for other environmental drivers (e.g., nutrient loading) toward the equator. These results and data set the stage for unprecedented “next-generation biomonitoring” by establishing baselines to help quantify environmental impacts to the functioning of ecosystems at a global scale.
Franco-Obregon, Alfredo ; Cambria, Elena ; Greutert, Helen ; Wernas, Timon ; Hitzl, Wolfgang ; Egli, Marcel ; Sekiguchi, Miho ; Boos, Norbert ; Hausmann, Oliver ; Ferguson, Stephen J. ; Kobayashi, Hiroshi ; Würtz-Kozak, Karin
Purpose Prolonged bed rest and microgravity in space cause intervertebral disc (IVD) degeneration. However, the underlying molecular mechanisms are not completely understood. Transient receptor potential canonical (TRPC) channels are implicated in mechanosensing of several tissues, but are poorly explored in IVDs. Methods Primary human IVD cells from surgical biopsies composed of both annulus fibrosus and nucleus pulposus (passage 1-2) were exposed to simulated microgravity and to the TRPC channel inhibitor SKF-96365 (SKF) for up to 5days. Proliferative capacity, cell cycle distribution, senescence and TRPC channel expression were analyzed. Results Both simulated microgravity and TRPC channel antagonism reduced the proliferative capacity of IVD cells and induced senescence. While significant changes in cell cycle distributions (reduction in G1 and accumulation in G2/M) were observed upon SKF treatment, the effect was small upon 3days of simulated microgravity. Finally, downregulation of TRPC6 was shown under simulated microgravity. Conclusions Simulated microgravity and TRPC channel inhibition both led to reduced proliferation and increased senescence. Furthermore, simulated microgravity reduced TRPC6 expression. IVD cell senescence and mechanotransduction may hence potentially be regulated by TRPC6 expression. This study thus reveals promising targets for future studies.
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