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Rapid Synthesis of Sub-10nm Hexagonal NaYF4-Based Upconverting Nanoparticles using Therminol((R))66
(2018)
We report a simple one-pot method for the rapid preparation of sub-10nm pure hexagonal (-phase) NaYF4-based upconverting nanoparticles (UCNPs). Using Therminol((R))66 as a co-solvent, monodisperse UCNPs could be obtained in unusually short reaction times. By varying the reaction time and reaction temperature, it was possible to control precisely the particle size and crystalline phase of the UCNPs. The upconversion (UC) luminescence properties of the nanocrystals were tuned by varying the concentrations of the dopants (Nd3+ and Yb3+ sensitizer ions and Er3+ activator ions). The size and phase-purity of the as-synthesized core and core-shell nanocrystals were assessed by using complementary transmission electron microscopy, dynamic light scattering, X-ray diffraction, and small-angle X-ray scattering studies. In-depth photophysical evaluation of the UCNPs was pursued by using steady-state and time-resolved luminescence spectroscopy. An enhancement in the UC intensity was observed if the nanocrystals, doped with optimized concentrations of lanthanide sensitizer/activator ions, were further coated with an inert/active shell. This was attributed to the suppression of surface-related luminescence quenching effects.
During the overall development of complex engineering systems different modeling notations are employed. For example, in the domain of automotive systems system engineering models are employed quite early to capture the requirements and basic structuring of the entire system, while software engineering models are used later on to describe the concrete software architecture. Each model helps in addressing the specific design issue with appropriate notations and at a suitable level of abstraction. However, when we step forward from system design to the software design, the engineers have to ensure that all decisions captured in the system design model are correctly transferred to the software engineering model. Even worse, when changes occur later on in either model, today the consistency has to be reestablished in a cumbersome manual step. In this report, we present in an extended version of [Holger Giese, Stefan Neumann, and Stephan Hildebrandt. Model Synchronization at Work: Keeping SysML and AUTOSAR Models Consistent. In Gregor Engels, Claus Lewerentz, Wilhelm Schäfer, Andy Schürr, and B. Westfechtel, editors, Graph Transformations and Model Driven Enginering - Essays Dedicated to Manfred Nagl on the Occasion of his 65th Birthday, volume 5765 of Lecture Notes in Computer Science, pages 555–579. Springer Berlin / Heidelberg, 2010.] how model synchronization and consistency rules can be applied to automate this task and ensure that the different models are kept consistent. We also introduce a general approach for model synchronization. Besides synchronization, the approach consists of tool adapters as well as consistency rules covering the overlap between the synchronized parts of a model and the rest. We present the model synchronization algorithm based on triple graph grammars in detail and further exemplify the general approach by means of a model synchronization solution between system engineering models in SysML and software engineering models in AUTOSAR which has been developed for an industrial partner. In the appendix as extension to [19] the meta-models and all TGG rules for the SysML to AUTOSAR model synchronization are documented.
The correctness of model transformations is a crucial element for the model-driven engineering of high quality software. A prerequisite to verify model transformations at the level of the model transformation specification is that an unambiguous formal semantics exists and that the employed implementation of the model transformation language adheres to this semantics. However, for existing relational model transformation approaches it is usually not really clear under which constraints particular implementations are really conform to the formal semantics. In this paper, we will bridge this gap for the formal semantics of triple graph grammars (TGG) and an existing efficient implementation. Whereas the formal semantics assumes backtracking and ignores non-determinism, practical implementations do not support backtracking, require rule sets that ensure determinism, and include further optimizations. Therefore, we capture how the considered TGG implementation realizes the transformation by means of operational rules, define required criteria and show conformance to the formal semantics if these criteria are fulfilled. We further outline how static analysis can be employed to guarantee these criteria.
Model-driven software development requires techniques to consistently propagate modifications between different related models to realize its full potential. For large-scale models, efficiency is essential in this respect. In this paper, we present an improved model synchronization algorithm based on triple graph grammars that is highly efficient and, therefore, can also synchronize large-scale models sufficiently fast. We can show, that the overall algorithm has optimal complexity if it is dominating the rule matching and further present extensive measurements that show the efficiency of the presented model transformation and synchronization technique.
The correctness of model transformations is a crucial element for model-driven engineering of high-quality software. A prerequisite to verify model transformations at the level of the model transformation specification is that an unambiguous formal semantics exists and that the implementation of the model transformation language adheres to this semantics. However, for existing relational model transformation approaches, it is usually not really clear under which constraints particular implementations really conform to the formal semantics. In this paper, we will bridge this gap for the formal semantics of triple graph grammars (TGG) and an existing efficient implementation. While the formal semantics assumes backtracking and ignores non-determinism, practical implementations do not support backtracking, require rule sets that ensure determinism, and include further optimizations. Therefore, we capture how the considered TGG implementation realizes the transformation by means of operational rules, define required criteria, and show conformance to the formal semantics if these criteria are fulfilled. We further outline how static and runtime checks can be employed to guarantee these criteria.
Rapid synthesis of sub-10 nm hexagonal NaYF4-based upconverting nanoparticles using Therminol® 66
(2018)
We report a simple one-pot method for the rapid preparation of sub-10nm pure hexagonal (-phase) NaYF4-based upconverting nanoparticles (UCNPs). Using Therminol((R))66 as a co-solvent, monodisperse UCNPs could be obtained in unusually short reaction times. By varying the reaction time and reaction temperature, it was possible to control precisely the particle size and crystalline phase of the UCNPs. The upconversion (UC) luminescence properties of the nanocrystals were tuned by varying the concentrations of the dopants (Nd3+ and Yb3+ sensitizer ions and Er3+ activator ions). The size and phase-purity of the as-synthesized core and core-shell nanocrystals were assessed by using complementary transmission electron microscopy, dynamic light scattering, X-ray diffraction, and small-angle X-ray scattering studies. In-depth photophysical evaluation of the UCNPs was pursued by using steady-state and time-resolved luminescence spectroscopy. An enhancement in the UC intensity was observed if the nanocrystals, doped with optimized concentrations of lanthanide sensitizer/activator ions, were further coated with an inert/active shell. This was attributed to the suppression of surface-related luminescence quenching effects.
Der Arbeitskreis Militär und Gesellschaft in der Frühen Neuzeit e. V. wurde im Frühjahr 1995 gegründet. Er hat es sich zur Aufgabe gemacht, die Erforschung des Militärs im Rahmen der frühneuzeitlichen Geschichte zu befördern und zugleich das Bewusstsein der Frühneuzeit-HistorikerInnen für die Bedeutung des Militärs in all seinen Funktionen zu wecken. Das Militär steht somit als soziale Gruppe selbst im Mittelpunkt der Aktivitäten des Arbeitskreises, wird aber auch in seinen Wirkungen und Repräsentationen thematisiert. Ziel ist es, die Rolle des Militärs als Teil der frühneuzeitlichen Gesellschaft umfassend herauszuarbeiten und zu würdigen. Insofern versteht der AMG seine Arbeit nicht nur als Beitrag zur Militärgeschichte, sondern vor allem als Beitrag zur Geschichte der Frühen Neuzeit insgesamt. Der Arbeitskreis bietet ein Diskussions- und Informationsforum durch die Organisation von Tagungen, die Herausgabe der Schriftenreihe ‚Herrschaft und soziale Systeme in der Frühen Neuzeit‘, die Zeitschrift ‚Militär und Gesellschaft in der Frühen Neuzeit‘ und die Mailingliste mil-fnz.
A catalog of genetic loci associated with kidney function from analyses of a million individuals
(2019)
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.