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We report on simultaneous broadband observations of the TeV-emitting blazar Markarian 501 between 2013 April 1 and August 10, including the first detailed characterization of the synchrotron peak with Swift and NuSTAR. During the campaign, the nearby BL Lac object was observed in both a quiescent and an elevated state. The broadband campaign includes observations with NuSTAR, MAGIC, VERITAS, the Fermi Large Area Telescope, Swift X-ray Telescope and UV Optical Telescope, various ground-based optical instruments, including the GASP-WEBT program, as well as radio observations by OVRO, Metsahovi, and the F-Gamma consortium. Some of the MAGIC observations were affected by a sand layer from the Saharan desert, and had to be corrected using event-by-event corrections derived with a Light Detection and Ranging (LIDAR) facility. This is the first time that LIDAR information is used to produce a physics result with Cherenkov Telescope data taken during adverse atmospheric conditions, and hence sets a precedent for the current and future ground-based gamma-ray instruments. The NuSTAR instrument provides unprecedented sensitivity in hard X-rays, showing the source to display a spectral energy distribution (SED) between 3 and 79 keV consistent with a log-parabolic spectrum and hard X-ray variability on hour timescales. None (of the four extended NuSTAR observations) show evidence of the onset of inverse-Compton emission at hard X-ray energies. We apply a single-zone equilibrium synchrotron self-Compton (SSC) model to five simultaneous broadband SEDs. We find that the SSC model can reproduce the observed broadband states through a decrease in the magnetic field strength coinciding with an increase in the luminosity and hardness of the relativistic leptons responsible for the high-energy emission.
The origin of the First Bend of the Yangtze River is key to understanding the birth of the modern Yangtze River. Despite considerable efforts, the timing and mechanism of formation of the First Bend remain highly debated. Inverse river-profile modeling of three tributaries (Chongjiang, Lima, and Gudu) of the Jinsha River, integrated with regional tectonic and geomorphic interpretations, allows the onset of incision at the First Bend to be constrained to 28-20 Ma. The spatio-temporal coincidence of initial river incision and activity of Yulong Thrust Belt in southeastern Tibet highlights thrusting to be fundamental in reshaping the pre-existing stream network at the First Bend. These results enable us to reinterpret a change in sedimentary environment from a braided river to a swamp-like lake in the Jianchuan Basin south of the First Bend, recording the destruction of the hypothesized southwards-flowing paleo-Jinsha and Shuiluo Rivers at ~36-35 Ma by magmatism. During the late Oligoceneearly Miocene, the paleo-Shuiluo River was diverted to the north by focused rock uplift due to thrusting along the Yulong Thrust Belt, which also led to exhumation of the Jianchuan Basin. Diversion of the paleo-Shuiluo River can be explained by capture from a downstream river in the footwall of the Yulong Thrust Belt. Subsequent rapid headward erosion, that was caused by thrusting-induced drop of local base level, is recorded by upstream younging ages for the onset of incision and led to the formation of the First Bend. The combination of new ages for the onset of incision at 28-20 Ma at the First Bend and younger ages upstream indicates northwards expansion of the Jinsha River at a rate of 62 +/- 18 mm/yr. Our results suggest that the origin of the First Bend was likely triggered by thrusting at 28-20 Ma, after which the Yangtze River formed.
The “HPI Future SOC Lab” is a cooperation of the Hasso Plattner Institute (HPI) and industry partners. Its mission is to enable and promote exchange and interaction between the research community and the industry partners.
The HPI Future SOC Lab provides researchers with free of charge access to a complete infrastructure of state of the art hard and software. This infrastructure includes components, which might be too expensive for an ordinary research environment, such as servers with up to 64 cores and 2 TB main memory. The offerings address researchers particularly from but not limited to the areas of computer science and business information systems. Main areas of research include cloud computing, parallelization, and In-Memory technologies.
This technical report presents results of research projects executed in 2017. Selected projects have presented their results on April 25th and November 15th 2017 at the Future SOC Lab Day events.
A catalog of genetic loci associated with kidney function from analyses of a million individuals
(2019)
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.