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HiN : Alexander von Humboldt im Netz = Festschrift für Margot Faak zu Ehren ihres 80. Geburtstages
(2006)
Inhalt:
- Die Mitarbeiter der Avh-Forschungsstelle: Margot Faak zum 80. Geburtstag
- Marie-Noëlle Bourguet: La fabrique du savoir. Essai sur les carnets de voyage d'Alexander von Humboldt
- Ottmar Ette: Unterwegs zu einer Weltwissenschaft? Alexander von Humboldts Weltbegriffe und die transarealen Studien
- Eberhard Knobloch: Erkundung und Erforschung - Alexander von Humboldts Amerikareise
- Herbert Pieper: Die Geognosie der Vulkane
- Christian Suckow: Prinz Humboldt
- Ursula Thiemer-Sachse: ¡Qué arte es comprender el arte ...! La visión del arte indígena de América por Alejandro de Humboldt
- Margot Faak: G. W. Leibniz im Urteil Alexander von Humboldts
- Regina Mikosch, Ingo Schwarz: Bibliographie zu Margot Faak
Herbert Pieper zum 65. Geburtstag
Inhalt:
- Eberhard Knobloch: Herbert Pieper zum 65. Geburtstag. Ein Rückblick
- Bernd Kölbel, Martin Sauerwein, Katrin Sauerwein, Steffen Kölbel, Cathleen Buckow: Das Fragment des englischen Tagebuches von Alexander von Humboldt
- Ulrike Leitner: Humboldt, Cotta, Ritter. Eine Miszelle über die Arbeit an einer Edition
- Ingo Schwarz: "da ich mich lebhaft für sein Schiksal im Neuen Continent interessire". A. v. Humboldt als Förderer Oscar M. Liebers
- Christian Suckow: Humboldts spanische Option 1830. Eine Nachlese
- Petra Werner: Bemerkungen zu Alexander von Humboldts Russland-Tagebuch
- Herbert Pieper Alexander von Humboldts Wahl in die Akademie der Wissenschaften zu Berlin
- Publikationen von Herbert Pieper [Bibliographie]
Brain capillary pericytes contribute to the immune defense in response to cytokines or LPS in vitro
(2014)
The prevention of an inflammation in the brain is one of the most important goals the body has to achieve. As pericytes are located on the abluminal side of the capillaries in the brain, their role in fighting against invading pathogens has been investigated in some points, mostly in their ability to behave like macrophages. Here we studied the potential of pericytes to react as immune cells under inflammatory conditions, especially regarding the expression of the inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), major histocompatibility complex II (MHC II) molecules, CD68, as well as the generation of reactive oxygen and nitrogen species (RONS), and their ability in phagocytosis. Quantitative real time PCR and western blot analysis showed that pericytes are able to increase the expression of typical inflammatory marker proteins after the stimulation with tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1 beta), interferon-gamma (IFN-gamma), or lipopolysaccharides (LPS). Depending on the different specific pro-inflammatory factors pericytes changed the expression of alpha smooth muscle actin (alpha SMA), the most predominant pericyte marker. We conclude that the role of the pericytes within the immune system is regulated and fine-tuned by different cytokines strongly depending on the time when the cytokines are released and their concentration. The present results will help to understand the pericyte mediated defense mechanisms in the brain.