Refine
Year of publication
Document Type
- Article (27)
- Postprint (5)
- Review (2)
- Monograph/Edited Volume (1)
Language
- English (35)
Is part of the Bibliography
- yes (35)
Keywords
- Drug delivery (2)
- acute kidney injury (2)
- adiposity (2)
- all-cause mortality (2)
- anthropometric measures (2)
- cancer (2)
- end-stage kidney disease (2)
- genome-wide association (2)
- heterojunction silicon solar cells (2)
- interfaces (2)
- keratinocytes (2)
- mass index (2)
- nanoparticles (2)
- nanotoxicology (2)
- overweight (2)
- particle characterization (2)
- perovskite solar cells (2)
- prediction (2)
- rapid eGFRcrea decline (2)
- size (2)
- study (2)
- tandem solar cells (2)
- thin films (2)
- Alaska (1)
- Altai Mountains (1)
- BL Lacertae objects: general (1)
- Biodiversity indicators (1)
- Cloud Computing (1)
- EMIC waves (1)
- Eurasian Dry Grassland Group (EDGG) (1)
- European Vegetation Archive (EVA) (1)
- FT-ICR MS (1)
- Forschungsprojekte (1)
- Future SOC Lab (1)
- GrassPlot (1)
- In-Memory Technologie (1)
- In-Memory technology (1)
- India-Asia collision (1)
- Kanas Lake (1)
- Künstliche Intelligenz (1)
- Linear theory (1)
- Multicore Architekturen (1)
- Pettitt test (1)
- Van Allen Probes (1)
- Wave generation (1)
- X-rays: galaxies (1)
- alleles (1)
- artifical intelligence (1)
- biobanks (1)
- biodiversity (1)
- birth weight (1)
- carbon (1)
- climate change (1)
- cloud computing (1)
- continental earthquakes (1)
- correlation (1)
- debris flows (1)
- duration of gestation (1)
- earthquake-induced landslides (1)
- electrospinning (1)
- fertilization (1)
- fetus (1)
- fiber meshes (1)
- galaxies: individual (Markarian 501) (1)
- genetics (1)
- genome-wide association study (1)
- genotype (1)
- geohazards (1)
- grassland management (1)
- grassland vegetation (1)
- grazing (1)
- land-use change (1)
- land-use intensity (1)
- landscape evolution (1)
- machine learning (1)
- macroecology (1)
- maschinelles Lernen (1)
- microbes (1)
- mothers (1)
- mowing (1)
- multi-taxon (1)
- multicore architectures (1)
- multidiversity (1)
- multitrophic interactions (1)
- nested plot (1)
- offspring (1)
- paleomagnetism applied to tectonics (1)
- permafrost (1)
- potential evapotranspiration (1)
- precipitation (1)
- remagnetization (1)
- research projects (1)
- reversible shape-memory effect (1)
- rock and mineral magnetism (1)
- runoff (1)
- sPlot (1)
- scale-dependence (1)
- sediment cascade (1)
- sensitivity (1)
- single nucleotide polymorphism (1)
- species-area relationship (SAR) (1)
- taiga forest (1)
- vegetation dynamics (1)
- vegetation-plot database (1)
- yedoma (1)
Institute
- Institut für Biochemie und Biologie (7)
- Institut für Physik und Astronomie (7)
- Institut für Ernährungswissenschaft (6)
- Institut für Geowissenschaften (5)
- Hasso-Plattner-Institut für Digital Engineering GmbH (4)
- Institut für Chemie (3)
- Institut für Umweltwissenschaften und Geographie (2)
- Mathematisch-Naturwissenschaftliche Fakultät (1)
Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.
Land-use intensification is a key driver of biodiversity change. However, little is known about how it alters relationships between the diversities of different taxonomic groups, which are often correlated due to shared environmental drivers and trophic interactions. Using data from 150 grassland sites, we examined how land-use intensification (increased fertilization, higher livestock densities, and increased mowing frequency) altered correlations between the species richness of 15 plant, invertebrate, and vertebrate taxa. We found that 54% of pairwise correlations between taxonomic groups were significant and positive among all grasslands, while only one was negative. Higher land-use intensity substantially weakened these correlations(35% decrease in rand 43% fewer significant pairwise correlations at high intensity), a pattern which may emerge as a result of biodiversity declines and the breakdown of specialized relationships in these conditions. Nevertheless, some groups (Coleoptera, Heteroptera, Hymenoptera and Orthoptera) were consistently correlated with multidiversity, an aggregate measure of total biodiversity comprised of the standardized diversities of multiple taxa, at both high and lowland-use intensity. The form of intensification was also important; increased fertilization and mowing frequency typically weakened plant-plant and plant-primary consumer correlations, whereas grazing intensification did not. This may reflect decreased habitat heterogeneity under mowing and fertilization and increased habitat heterogeneity under grazing. While these results urge caution in using certain taxonomic groups to monitor impacts of agricultural management on biodiversity, they also suggest that the diversities of some groups are reasonably robust indicators of total biodiversity across a range of conditions.
Aggregation of chromophores in the solid state commonly causes undesirable red shifts in the emission spectra and/or emission quenching. To overcome this problem, we have prepared soluble perylenetetracarboxidiimide dyes in which the chromophores are effectively shielded by polyphenylene dendrimers attached in the bay positions. Models show that attachment of the shielding units in the bay position should provide more efficient shielding than attaching them via the imide moieties. The dendrimers possess excellent film-forming properties due to alkyl substituents on their peripheries. The lack of a red shift in emission upon going from solution to the solid state indicates the dendrons suppress interaction of the emissive cores, leading to pure red-orange emission. Single-layer LEDs produce red-orange emission with relatively low efficiency especially for the higher generation dendrons, which is attributed to poor charge conduction. LEDs using blends of the dendrimers and the undendronized dye as a model compound in PVK have been investigated, and a model to extract relative charge injection rates through the dendritic scaffold from the spectral contributions in the EL spectra is developed
Pollen records from large lakes have been used for quantitative palaeoclimate reconstruction, but the influences that lake size (as a result of species-specific variations in pollen dispersal patterns that smaller pollen grains are more easily transported to lake centre) and taphonomy have on these climatic signals have not previously been systematically investigated. We introduce the concept of pollen source area to pollen-based climate calibration using the north-eastern Tibetan Plateau as our study area. We present a pollen data set collected from large lakes in the arid to semi-arid region of central Asia. The influences that lake size and the inferred pollen source areas have on pollen compositions have been investigated through comparisons with pollen assemblages in neighbouring lakes of various sizes. Modern pollen samples collected from different parts of Lake Donggi Cona (in the north-eastern part of the Tibetan Plateau) reveal variations in pollen assemblages within this large lake, which are interpreted in terms of the species-specific dispersal and depositional patterns for different types of pollen, and in terms of fluvial input components. We have estimated the pollen source area for each lake individually and used this information to infer modern climate data with which to then develop a modern calibration data set, using both the multivariate regression tree (MRT) and weighted-averaging partial least squares (WA-PLS) approaches. Fossil pollen data from Lake Donggi Cona have been used to reconstruct the climate history of the north-eastern part of the Tibetan Plateau since the Last Glacial Maximum (LGM). The meanannual precipitation was quantitatively reconstructed using WA-PLS: extremely dry conditions are found to have dominated the LGM, with annual precipitation of around 100 mm, which is only 32% of present-day precipitation. A gradually increasing trend in moisture conditions during the Late Glacial is terminated by an abrupt reversion to a dry phase that lasts for about 1000 yr and coincides with "Heinrich event 1" in the North Atlantic region. Subsequent periods corresponding to the Bolling/Allerod interstadial, with annual precipitation (P-ann) of about 350 mm, and the Younger Dryas event (about 270 mm P-ann) are followed by moist conditions in the early Holocene, with annual precipitation of up to 400 mm. A drier trend after 9 cal. ka BP is followed by a second wet phase in the middle Holocene, lasting until 4.5 cal. ka BP. Relatively steady conditions with only slight fluctuations then dominate the late Holocene, resulting in the present climatic conditions. The climate changes since the LGM have been primarily driven by deglaciation and fluctuations in the intensity of the Asian summer monsoon that resulted from changes in the Northern Hemisphere summer solar insolation, as well as from changes in the North Atlantic climate through variations in the circulation patterns and intensity of the westerlies.
The “HPI Future SOC Lab” is a cooperation of the Hasso Plattner Institute (HPI) and industry partners. Its mission is to enable and promote exchange and interaction between the research community and the industry partners.
The HPI Future SOC Lab provides researchers with free of charge access to a complete infrastructure of state of the art hard and software. This infrastructure includes components, which might be too expensive for an ordinary research environment, such as servers with up to 64 cores and 2 TB main memory. The offerings address researchers particularly from but not limited to the areas of computer science and business information systems. Main areas of research include cloud computing, parallelization, and In-Memory technologies.
This technical report presents results of research projects executed in 2017. Selected projects have presented their results on April 25th and November 15th 2017 at the Future SOC Lab Day events.