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Furniss, A. ; Noda, K. ; Boggs, S. ; Chiang, J. ; Christensen, F. ; Craig, W. ; Giommi, P. ; Hailey, C. ; Harisson, F. ; Madejski, G. ; Nalewajko, K. ; Perri, M. ; Stern, D. ; Urry, M. ; Verrecchia, F. ; Zhang, W. ; Ahnen, M. L. ; Ansoldi, S. ; Antonelli, L. A. ; Antoranz, P. ; Babic, A. ; Banerjee, B. ; Bangale, P. ; de Almeida, U. Barres ; Barrio, J. A. ; Becerra Gonzalez, J. ; Bednarek, W. ; Bernardini, E. ; Biasuzzi, B. ; Biland, A. ; Blanch Bigas, O. ; Bonnefoy, S. ; Bonnoli, G. ; Borracci, F. ; Bretz, T. ; Carmona, E. ; Carosi, A. ; Chatterjee, A. ; Clavero, R. ; Colin, P. ; Colombo, E. ; Contreras, J. L. ; Cortina, J. ; Covino, S. ; Da Vela, P. ; Dazzi, F. ; De Angelis, A. ; De Caneva, G. ; De Lotto, B. ; de Ona Wilhelmi, E. ; Delgado Mendez, C. ; Di Pierro, F. ; Prester, Dijana Dominis ; Dorner, D. ; Doro, M. ; Einecke, S. ; Eisenacher Glawion, D. ; Elsaesser, D. ; Fernandez-Barral, A. ; Fidalgo, D. ; Fonseca, M. V. ; Font, L. ; Frantzen, K. ; Fruck, C. ; Galindo, D. ; Garcia Lopez, R. J. ; Garczarczyk, M. ; Garrido Terrats, D. ; Gaug, M. ; Giammaria, P. ; Godinovic, N. ; Gonzalez Munoz, A. ; Guberman, D. ; Hanabata, Y. ; Hayashida, M. ; Herrera, J. ; Hose, J. ; Hrupec, D. ; Hughes, G. ; Idec, W. ; Kellermann, H. ; Kodani, K. ; Konno, Y. ; Kubo, H. ; Kushida, J. ; La Barbera, A. ; Lelas, D. ; Lewandowska, N. ; Lindfors, E. ; Lombardi, S. ; Longo, F. ; Lopez, M. ; Lopez-Coto, R. ; Lopez-Oramas, A. ; Lorenz, E. ; Majumdar, P. ; Makariev, M. ; Mallot, K. ; Maneva, G. ; Manganaro, M. ; Mannheim, K. ; Maraschi, L. ; Marcote, B. ; Mariotti, M. ; Martinez, M. ; Mazin, D. ; Menzel, U. ; Miranda, J. M. ; Mirzoyan, R. ; Moralejo, A. ; Nakajima, D. ; Neustroev, V. ; Niedzwiecki, A. ; Nievas Rosillo, M. ; Nilsson, K. ; Nishijima, K. ; Orito, R. ; Overkemping, A. ; Paiano, S. ; Palacio, J. ; Palatiello, M. ; Paneque, D. ; Paoletti, R. ; Paredes, J. M. ; Paredes-Fortuny, X. ; Persic, M. ; Poutanen, J. ; Moroni, P. G. Prada ; Prandini, E. ; Puljak, I. ; Reinthal, R. ; Rhode, W. ; Ribo, M. ; Rico, J. ; Garcia, J. Rodriguez ; Saito, T. ; Saito, K. ; Satalecka, K. ; Scapin, V. ; Schultz, C. ; Schweizer, T. ; Shore, S. N. ; Sillanpaa, A. ; Sitarek, J. ; Snidaric, I. ; Sobczynska, D. ; Stamerra, A. ; Steinbring, T. ; Strzys, M. ; Takalo, L. ; Takami, H. ; Tavecchio, F. ; Temnikov, P. ; Terzic, T. ; Tescaro, D. ; Teshima, M. ; Thaele, J. ; Torres, D. F. ; Toyama, T. ; Treves, A. ; Verguilov, V. ; Vovk, I. ; Will, M. ; Zanin, R. ; Archer, A. ; Benbow, W. ; Bird, R. ; Biteau, Jonathan ; Bugaev, V. ; Cardenzana, J. V. ; Cerruti, M. ; Chen, Xuhui ; Ciupik, L. ; Connolly, M. P. ; Cui, W. ; Dickinson, H. J. ; Dumm, J. ; Eisch, J. D. ; Falcone, A. ; Feng, Q. ; Finley, J. P. ; Fleischhack, H. ; Fortin, P. ; Fortson, L. ; Gerard, L. ; Gillanders, G. H. ; Griffin, S. ; Griffiths, S. T. ; Grube, J. ; Gyuk, G. ; Hakansson, Nils ; Holder, J. ; Humensky, T. B. ; Johnson, C. A. ; Kaaret, P. ; Kertzman, M. ; Kieda, D. ; Krause, M. ; Krennrich, F. ; Lang, M. J. ; Lin, T. T. Y. ; Maier, G. ; McArthur, S. ; McCann, A. ; Meagher, K. ; Moriarty, P. ; Mukherjee, R. ; Nieto, D. ; Ong, R. A. ; Park, N. ; Petry, D. ; Pohl, Martin ; Popkow, A. ; Ragan, K. ; Ratliff, G. ; Reyes, L. C. ; Reynolds, P. T. ; Richards, G. T. ; Roache, E. ; Santander, M. ; Sembroski, G. H. ; Shahinyan, K. ; Staszak, D. ; Telezhinsky, Igor O. ; Tucci, J. V. ; Tyler, J. ; Vassiliev, V. V. ; Wakely, S. P. ; Weiner, O. M. ; Weinstein, A. ; Wilhelm, Alina ; Williams, D. A. ; Zitzer, B. ; Vince, O. ; Fuhrmann, L. ; Angelakis, E. ; Karamanavis, V. ; Myserlis, I. ; Krichbaum, T. P. ; Zensus, J. A. ; Ungerechts, H. ; Sievers, A. ; Bachev, R. ; Boettcher, Markus ; Chen, W. P. ; Damljanovic, G. ; Eswaraiah, C. ; Guver, T. ; Hovatta, T. ; Hughes, Z. ; Ibryamov, S. I. ; Joner, M. D. ; Jordan, B. ; Jorstad, S. G. ; Joshi, M. ; Kataoka, J. ; Kurtanidze, O. M. ; Kurtanidze, S. O. ; Lahteenmaki, A. ; Latev, G. ; Lin, H. C. ; Larionov, V. M. ; Mokrushina, A. A. ; Morozova, D. A. ; Nikolashvili, M. G. ; Raiteri, C. M. ; Ramakrishnan, V. ; Readhead, A. C. R. ; Sadun, A. C. ; Sigua, L. A. ; Semkov, E. H. ; Strigachev, A. ; Tammi, J. ; Tornikoski, M. ; Troitskaya, Y. V. ; Troitsky, I. S. ; Villata, M.
We report on simultaneous broadband observations of the TeV-emitting blazar Markarian 501 between 2013 April 1 and August 10, including the first detailed characterization of the synchrotron peak with Swift and NuSTAR. During the campaign, the nearby BL Lac object was observed in both a quiescent and an elevated state. The broadband campaign includes observations with NuSTAR, MAGIC, VERITAS, the Fermi Large Area Telescope, Swift X-ray Telescope and UV Optical Telescope, various ground-based optical instruments, including the GASP-WEBT program, as well as radio observations by OVRO, Metsahovi, and the F-Gamma consortium. Some of the MAGIC observations were affected by a sand layer from the Saharan desert, and had to be corrected using event-by-event corrections derived with a Light Detection and Ranging (LIDAR) facility. This is the first time that LIDAR information is used to produce a physics result with Cherenkov Telescope data taken during adverse atmospheric conditions, and hence sets a precedent for the current and future ground-based gamma-ray instruments. The NuSTAR instrument provides unprecedented sensitivity in hard X-rays, showing the source to display a spectral energy distribution (SED) between 3 and 79 keV consistent with a log-parabolic spectrum and hard X-ray variability on hour timescales. None (of the four extended NuSTAR observations) show evidence of the onset of inverse-Compton emission at hard X-ray energies. We apply a single-zone equilibrium synchrotron self-Compton (SSC) model to five simultaneous broadband SEDs. We find that the SSC model can reproduce the observed broadband states through a decrease in the magnetic field strength coinciding with an increase in the luminosity and hardness of the relativistic leptons responsible for the high-energy emission.
Renteria, Miguel E. ; Schmaal, L. ; Hibar, D. P. ; Couvy-Duchesne, B. ; Strike, L. T. ; Mills, N. T. ; de Zubicaray, Greig. I. ; McMahon, Katie. L. ; Medland, Sarah E. ; Gillespie, N. A. ; Hatton, S. N. ; Lagopoulos, J. ; Veltman, D. J. ; van der Wee, N. ; van Erp, T. G. M. ; Wittfeld, K. ; Grabe, H. J. ; Block, Andrea ; Hegenscheid, K. ; Voelzke, H. ; Veer, I. M. ; Walter, H. ; Schnell, K. ; Schramm, E. ; Normann, C. ; Schoepf, Dieter ; Konrad, C. ; Zurowski, B. ; Godlewska, B. R. ; Cowen, P. J. ; Penninx, B. W. J. H. ; Jahanshad, N. ; Thompson, Paul M. ; Wright, M. J. ; Martin, N. G. ; Christensen, H. ; Hickie, I. B.
A catalog of genetic loci associated with kidney function from analyses of a million individuals
(2019)
Wuttke, Matthias ; Li, Yong ; Li, Man ; Sieber, Karsten B. ; Feitosa, Mary F. ; Gorski, Mathias ; Tin, Adrienne ; Wang, Lihua ; Chu, Audrey Y. ; Hoppmann, Anselm ; Kirsten, Holger ; Giri, Ayush ; Chai, Jin-Fang ; Sveinbjornsson, Gardar ; Tayo, Bamidele O. ; Nutile, Teresa ; Fuchsberger, Christian ; Marten, Jonathan ; Cocca, Massimiliano ; Ghasemi, Sahar ; Xu, Yizhe ; Horn, Katrin ; Noce, Damia ; Van der Most, Peter J. ; Sedaghat, Sanaz ; Yu, Zhi ; Akiyama, Masato ; Afaq, Saima ; Ahluwalia, Tarunveer Singh ; Almgren, Peter ; Amin, Najaf ; Arnlov, Johan ; Bakker, Stephan J. L. ; Bansal, Nisha ; Baptista, Daniela ; Bergmann, Sven ; Biggs, Mary L. ; Biino, Ginevra ; Boehnke, Michael ; Boerwinkle, Eric ; Boissel, Mathilde ; Böttinger, Erwin ; Boutin, Thibaud S. ; Brenner, Hermann ; Brumat, Marco ; Burkhardt, Ralph ; Butterworth, Adam S. ; Campana, Eric ; Campbell, Archie ; Campbell, Harry ; Canouil, Mickael ; Carroll, Robert J. ; Catamo, Eulalia ; Chambers, John C. ; Chee, Miao-Ling ; Chee, Miao-Li ; Chen, Xu ; Cheng, Ching-Yu ; Cheng, Yurong ; Christensen, Kaare ; Cifkova, Renata ; Ciullo, Marina ; Concas, Maria Pina ; Cook, James P. ; Coresh, Josef ; Corre, Tanguy ; Sala, Cinzia Felicita ; Cusi, Daniele ; Danesh, John ; Daw, E. Warwick ; De Borst, Martin H. ; De Grandi, Alessandro ; De Mutsert, Renee ; De Vries, Aiko P. J. ; Degenhardt, Frauke ; Delgado, Graciela ; Demirkan, Ayse ; Di Angelantonio, Emanuele ; Dittrich, Katalin ; Divers, Jasmin ; Dorajoo, Rajkumar ; Eckardt, Kai-Uwe ; Ehret, Georg ; Elliott, Paul ; Endlich, Karlhans ; Evans, Michele K. ; Felix, Janine F. ; Foo, Valencia Hui Xian ; Franco, Oscar H. ; Franke, Andre ; Freedman, Barry I. ; Freitag-Wolf, Sandra ; Friedlander, Yechiel ; Froguel, Philippe ; Gansevoort, Ron T. ; Gao, He ; Gasparini, Paolo ; Gaziano, J. Michael ; Giedraitis, Vilmantas ; Gieger, Christian ; Girotto, Giorgia ; Giulianini, Franco ; Gogele, Martin ; Gordon, Scott D. ; Gudbjartsson, Daniel F. ; Gudnason, Vilmundur ; Haller, Toomas ; Hamet, Pavel ; Harris, Tamara B. ; Hartman, Catharina A. ; Hayward, Caroline ; Hellwege, Jacklyn N. ; Heng, Chew-Kiat ; Hicks, Andrew A. ; Hofer, Edith ; Huang, Wei ; Hutri-Kahonen, Nina ; Hwang, Shih-Jen ; Ikram, M. Arfan ; Indridason, Olafur S. ; Ingelsson, Erik ; Ising, Marcus ; Jaddoe, Vincent W. V. ; Jakobsdottir, Johanna ; Jonas, Jost B. ; Joshi, Peter K. ; Josyula, Navya Shilpa ; Jung, Bettina ; Kahonen, Mika ; Kamatani, Yoichiro ; Kammerer, Candace M. ; Kanai, Masahiro ; Kastarinen, Mika ; Kerr, Shona M. ; Khor, Chiea-Chuen ; Kiess, Wieland ; Kleber, Marcus E. ; Koenig, Wolfgang ; Kooner, Jaspal S. ; Korner, Antje ; Kovacs, Peter ; Kraja, Aldi T. ; Krajcoviechova, Alena ; Kramer, Holly ; Kramer, Bernhard K. ; Kronenberg, Florian ; Kubo, Michiaki ; Kuhnel, Brigitte ; Kuokkanen, Mikko ; Kuusisto, Johanna ; La Bianca, Martina ; Laakso, Markku ; Lange, Leslie A. ; Langefeld, Carl D. ; Lee, Jeannette Jen-Mai ; Lehne, Benjamin ; Lehtimaki, Terho ; Lieb, Wolfgang ; Lim, Su-Chi ; Lind, Lars ; Lindgren, Cecilia M. ; Liu, Jun ; Liu, Jianjun ; Loeffler, Markus ; Loos, Ruth J. F. ; Lucae, Susanne ; Lukas, Mary Ann ; Lyytikainen, Leo-Pekka ; Magi, Reedik ; Magnusson, Patrik K. E. ; Mahajan, Anubha ; Martin, Nicholas G. ; Martins, Jade ; Marz, Winfried ; Mascalzoni, Deborah ; Matsuda, Koichi ; Meisinger, Christa ; Meitinger, Thomas ; Melander, Olle ; Metspalu, Andres ; Mikaelsdottir, Evgenia K. ; Milaneschi, Yuri ; Miliku, Kozeta ; Mishra, Pashupati P. ; Program, V. A. Million Veteran ; Mohlke, Karen L. ; Mononen, Nina ; Montgomery, Grant W. ; Mook-Kanamori, Dennis O. ; Mychaleckyj, Josyf C. ; Nadkarni, Girish N. ; Nalls, Mike A. ; Nauck, Matthias ; Nikus, Kjell ; Ning, Boting ; Nolte, Ilja M. ; Noordam, Raymond ; Olafsson, Isleifur ; Oldehinkel, Albertine J. ; Orho-Melander, Marju ; Ouwehand, Willem H. ; Padmanabhan, Sandosh ; Palmer, Nicholette D. ; Palsson, Runolfur ; Penninx, Brenda W. J. H. ; Perls, Thomas ; Perola, Markus ; Pirastu, Mario ; Pirastu, Nicola ; Pistis, Giorgio ; Podgornaia, Anna I. ; Polasek, Ozren ; Ponte, Belen ; Porteous, David J. ; Poulain, Tanja ; Pramstaller, Peter P. ; Preuss, Michael H. ; Prins, Bram P. ; Province, Michael A. ; Rabelink, Ton J. ; Raffield, Laura M. ; Raitakari, Olli T. ; Reilly, Dermot F. ; Rettig, Rainer ; Rheinberger, Myriam ; Rice, Kenneth M. ; Ridker, Paul M. ; Rivadeneira, Fernando ; Rizzi, Federica ; Roberts, David J. ; Robino, Antonietta ; Rossing, Peter ; Rudan, Igor ; Rueedi, Rico ; Ruggiero, Daniela ; Ryan, Kathleen A. ; Saba, Yasaman ; Sabanayagam, Charumathi ; Salomaa, Veikko ; Salvi, Erika ; Saum, Kai-Uwe ; Schmidt, Helena ; Schmidt, Reinhold ; Ben Schottker ; Schulz, Christina-Alexandra ; Schupf, Nicole ; Shaffer, Christian M. ; Shi, Yuan ; Smith, Albert V. ; Smith, Blair H. ; Soranzo, Nicole ; Spracklen, Cassandra N. ; Strauch, Konstantin ; Stringham, Heather M. ; Stumvoll, Michael ; Svensson, Per O. ; Szymczak, Silke ; Tai, E-Shyong ; Tajuddin, Salman M. ; Tan, Nicholas Y. Q. ; Taylor, Kent D. ; Teren, Andrej ; Tham, Yih-Chung ; Thiery, Joachim ; Thio, Chris H. L. ; Thomsen, Hauke ; Thorleifsson, Gudmar ; Toniolo, Daniela ; Tonjes, Anke ; Tremblay, Johanne ; Tzoulaki, Ioanna ; Uitterlinden, Andre G. ; Vaccargiu, Simona ; Van Dam, Rob M. ; Van der Harst, Pim ; Van Duijn, Cornelia M. ; Edward, Digna R. Velez ; Verweij, Niek ; Vogelezang, Suzanne ; Volker, Uwe ; Vollenweider, Peter ; Waeber, Gerard ; Waldenberger, Melanie ; Wallentin, Lars ; Wang, Ya Xing ; Wang, Chaolong ; Waterworth, Dawn M. ; Bin Wei, Wen ; White, Harvey ; Whitfield, John B. ; Wild, Sarah H. ; Wilson, James F. ; Wojczynski, Mary K. ; Wong, Charlene ; Wong, Tien-Yin ; Xu, Liang ; Yang, Qiong ; Yasuda, Masayuki ; Yerges-Armstrong, Laura M. ; Zhang, Weihua ; Zonderman, Alan B. ; Rotter, Jerome I. ; Bochud, Murielle ; Psaty, Bruce M. ; Vitart, Veronique ; Wilson, James G. ; Dehghan, Abbas ; Parsa, Afshin ; Chasman, Daniel I. ; Ho, Kevin ; Morris, Andrew P. ; Devuyst, Olivier ; Akilesh, Shreeram ; Pendergrass, Sarah A. ; Sim, Xueling ; Boger, Carsten A. ; Okada, Yukinori ; Edwards, Todd L. ; Snieder, Harold ; Stefansson, Kari ; Hung, Adriana M. ; Heid, Iris M. ; Scholz, Markus ; Teumer, Alexander ; Kottgen, Anna ; Pattaro, Cristian
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
The article structually estimates an on-the-job search model of job separations. Given each employer pays observably equivalent workers the same but wages are dispersed across employers, an employer's separation flow is the sum of an exogenous outflow unrelated to the wage and a job-to-job flow that decreases with the employer's wage. Using data from the Danish Integrated Database for Labour Market Research, the empirical results imply, as predicted by theory, that search effort declines with the wage. Furthermore, the estimates explain the employment effect, defined as the horizontal difference between the distribution of wages earned and the wage offer distribution
Selsing, Jonatan ; Malesani, D. ; Goldoni, P. ; Fynbo, Johan ; Krühler, T. ; Antonelli, L. A. ; Arabsalmani, M. ; Bolmer, J. ; Cano, Z. ; Christensen, L. ; Covino, S. ; De Cia, A. ; de Ugarte Postigo, A. ; Flores, H. ; Fliis, M. ; Gomboc, A. ; Greiner, J. ; Groot, P. ; Hammer, F. ; Hartoog, O. E. ; Heintz, K. E. ; Hjorth, J. ; Jakobsson, P. ; Japelj, J. ; Kann, D. A. ; Kaper, L. ; Ledoux, C. ; Leloudas, G. ; Levan, A. J. ; Maiorano, E. ; Melandri, A. ; Milvang-Jensen, B. ; Palazzi, E. ; Palmerio, J. T. ; Perley, D. A. ; Pian, E. ; Piranomonte, S. ; Pugliese, G. ; Sanchez-Ramirez, R. ; Savaglio, S. ; Schady, P. ; Schulze, S. ; Sollerman, J. ; Sparre, Martin ; Tagliaferri, G. ; Tanvir, N. R. ; Thone, C. C. ; Vergani, S. D. ; Vreeswijk, P. ; Watson, D. ; Wiersema, K. ; Wijers, R. ; Xu, D. ; Zafar, T.
In this work we present spectra of all gamma-ray burst (GRB) afterglows that have been promptly observed with the X-shooter spectrograph until 31/03/2017. In total, we have obtained spectroscopic observations of 103 individual GRBs observed within 48 hours of the GRB trigger. Redshifts have been measured for 97 per cent of these, covering a redshift range from 0.059 to 7.84. Based on a set of observational selection criteria that minimise biases with regards to intrinsic properties of the GRBs, the follow-up effort has been focused on producing a homogeneously selected sample of 93 afterglow spectra for GRBs discovered by the Swift satellite. We here provide a public release of all the reduced spectra, including continuum estimates and telluric absorption corrections. For completeness, we also provide reductions for the 18 late-time observations of the underlying host galaxies. We provide an assessment of the degree of completeness with respect to the parent GRB population, in terms of the X-ray properties of the bursts in the sample and find that the sample presented here is representative of the full Swift sample. We have constrained the fraction of dark bursts to be <28 per cent and confirm previous results that higher optical darkness is correlated with increased X-ray absorption. For the 42 bursts for which it is possible, we have provided a measurement of the neutral hydrogen column density, increasing the total number of published HI column density measurements by similar to 33 per cent. This dataset provides a unique resource to study the ISM across cosmic time, from the local progenitor surroundings to the intervening Universe.
Herrero, Mario ; Thornton, Philip K. ; Mason-D'Croz, Daniel ; Palmer, Jeda ; Bodirsky, Benjamin Leon ; Pradhan, Prajal ; Barrett, Christopher B. ; Benton, Tim G. ; Hall, Andrew ; Pikaar, Ilje ; Bogard, Jessica R. ; Bonnett, Graham D. ; Bryan, Brett A. ; Campbell, Bruce M. ; Christensen, Svend ; Clark, Michael ; Fanzo, Jessica ; Godde, Cecile M. ; Jarvis, Andy ; Loboguerrero, Ana Maria ; Mathys, Alexander ; McIntyre, C. Lynne ; Naylor, Rosamond L. ; Nelson, Rebecca ; Obersteiner, Michael ; Parodi, Alejandro ; Popp, Alexander ; Ricketts, Katie ; Smith, Pete ; Valin, Hugo ; Vermeulen, Sonja J. ; Vervoort, Joost ; van Wijk, Mark ; van Zanten, Hannah H. E. ; West, Paul C. ; Wood, Stephen A. ; Rockström, Johan
Food system innovations will be instrumental to achieving multiple Sustainable Development Goals (SDGs). However, major innovation breakthroughs can trigger profound and disruptive changes, leading to simultaneous and interlinked reconfigurations of multiple parts of the global food system. The emergence of new technologies or social solutions, therefore, have very different impact profiles, with favourable consequences for some SDGs and unintended adverse side-effects for others. Stand-alone innovations seldom achieve positive outcomes over multiple sustainability dimensions. Instead, they should be embedded as part of systemic changes that facilitate the implementation of the SDGs. Emerging trade-offs need to be intentionally addressed to achieve true sustainability, particularly those involving social aspects like inequality in its many forms, social justice, and strong institutions, which remain challenging. Trade-offs with undesirable consequences are manageable through the development of well planned transition pathways, careful monitoring of key indicators, and through the implementation of transparent science targets at the local level.
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