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Venomous snakes often display extensive variation in venom composition both between and within species. However, the mechanisms underlying the distribution of different toxins and venom types among populations and taxa remain insufficiently known. Rattlesnakes (Crotalus, Sistrurus) display extreme inter-and intraspecific variation in venom composition, centered particularly on the presence or absence of presynaptically neurotoxic phospholipases A2 such as Mojave toxin (MTX). Interspecific hybridization has been invoked as a mechanism to explain the distribution of these toxins across rattlesnakes, with the implicit assumption that they are adaptively advantageous. Here, we test the potential of adaptive hybridization as a mechanism for venom evolution by assessing the distribution of genes encoding the acidic and basic subunits of Mojave toxin across a hybrid zone between MTX-positive Crotalus scutulatus and MTX-negative C. viridis in southwestern New Mexico, USA. Analyses of morphology, mitochondrial and single copy-nuclear genes document extensive admixture within a narrow hybrid zone. The genes encoding the two MTX subunits are strictly linked, and found in most hybrids and backcrossed individuals, but not in C. viridis away from the hybrid zone. Presence of the genes is invariably associated with presence of the corresponding toxin in the venom. We conclude that introgression of highly lethal neurotoxins through hybridization is not necessarily favored by natural selection in rattlesnakes, and that even extensive hybridization may not lead to introgression of these genes into another species.
Venomous snakes often display extensive variation in venom composition both between and within species. However, the mechanisms underlying the distribution of different toxins and venom types among populations and taxa remain insufficiently known. Rattlesnakes (Crotalus, Sistrurus) display extreme inter-and intraspecific variation in venom composition, centered particularly on the presence or absence of presynaptically neurotoxic phospholipases A2 such as Mojave toxin (MTX). Interspecific hybridization has been invoked as a mechanism to explain the distribution of these toxins across rattlesnakes, with the implicit assumption that they are adaptively advantageous. Here, we test the potential of adaptive hybridization as a mechanism for venom evolution by assessing the distribution of genes encoding the acidic and basic subunits of Mojave toxin across a hybrid zone between MTX-positive Crotalus scutulatus and MTX-negative C. viridis in southwestern New Mexico, USA. Analyses of morphology, mitochondrial and single copy-nuclear genes document extensive admixture within a narrow hybrid zone. The genes encoding the two MTX subunits are strictly linked, and found in most hybrids and backcrossed individuals, but not in C. viridis away from the hybrid zone. Presence of the genes is invariably associated with presence of the corresponding toxin in the venom. We conclude that introgression of highly lethal neurotoxins through hybridization is not necessarily favored by natural selection in rattlesnakes, and that even extensive hybridization may not lead to introgression of these genes into another species.
A common misconception persists that the genomes of toxic and non-toxic cyanobacterial strains are largely conserved with the exception of the presence or absence of the genes responsible for toxin production. Implementation of -omics era technologies has challenged this paradigm, with comparative analyses providing increased insight into the differences between strains of the same species. The implementation of genomic, transcriptomic and proteomic approaches has revealed distinct profiles between toxin-producing and non-toxic strains. Further, metagenomics and metaproteomics highlight the genomic potential and functional state of toxic bloom events over time. In this review, we highlight how these technologies have shaped our understanding of the complex relationship between these molecules, their producers and the environment at large within which they persist.
We report the detection of extended Ly alpha emission around individual star-forming galaxies at redshifts z = 3-6 in an ultradeep exposure of the Hubble Deep Field South obtained with MUSE on the ESO-VLT. The data reach a limiting surface brightness (1 sigma) of similar to 1 x 10(-19) erg s(-1) cm(-2) arcsec(-2) in azimuthally averaged radial profiles, an order of magnitude improvement over previous narrowband imaging. Our sample consists of 26 spectroscopically confirmed Ly alpha-emitting, but mostly continuum-faint (m(AB) greater than or similar to 27) galaxies. In most objects the Ly alpha emission is considerably more extended than the UV continuum light. While five of the faintest galaxies in the sample show no significantly detected Ly alpha haloes, the derived upper limits suggest that this is due to insufficient S/N. Ly alpha haloes therefore appear to be ubiquitous even for low-mass (similar to 10(8)-10(9) M-circle dot) star-forming galaxies at z > 3. We decompose the Ly alpha emission of each object into a compact component tracing the UV continuum and an extended halo component, and infer sizes and luminosities of the haloes. The extended Ly alpha emission approximately follows an exponential surface brightness distribution with a scale length of a few kpc. While these haloes are thus quite modest in terms of their absolute sizes, they are larger by a factor of 5-15 than the corresponding rest-frame UV continuum sources as seen by HST. They are also much more extended, by a factor similar to 5, than Ly alpha haloes around low-redshift star-forming galaxies. Between similar to 40% and greater than or similar to 90% of the observed Ly alpha flux comes from the extended halo component, with no obvious correlation of this fraction with either the absolute or the relative size of the Ly alpha halo. Our observations provide direct insights into the spatial distribution of at least partly neutral gas residing in the circumgalactic medium of low to intermediate mass galaxies at z > 3.
Adaptation to physical activity and mental stress in the context of pain. Psychobiological aspects
(2016)
The genesis of chronic pain is predominantly explained by a multidimensional pain model approach that is based on the dysfunctional influence of biological, psychological and social variables as key risk factors inducing aberrant long-term changes. Biological facets comprise adaptation processes on the neuronal, musculoskeletal and (psycho) biological level that can be influenced by physical training or psychosocial factors, such as stress. These factors can play a causative role in developing dysfunctional adaptation mechanisms, which in turn prepare the biological ground to facilitate negative long-term changes in the peripheral and central nervous systems. Hence, these processes can be assumed to be fundamentally involved in the transition from acute to chronic and persistent pain. The aim of this review article is to discuss hypotheses for the genesis of chronic pain and possible treatment strategies. Selected research results about maladaptive processes in chronic pain due to psychological stress and physical activity are presented in order to inspire discussions about the ideal dose-response relationship of physical activity and the combination of different therapeutic concepts.
Evolutionary history and conservation significance of the Javan leopard Panthera pardus melas
(2016)
The leopard Panthera pardus is widely distributed across Africa and Asia; however, there is a gap in its natural distribution in Southeast Asia, where it occurs on the mainland and on Java but not on the interjacent island of Sumatra. Several scenarios have been proposed to explain this distribution gap. Here, we complemented an existing dataset of 68 leopard mtDNA sequences from Africa and Asia with mtDNA sequences (NADH5+ ctrl, 724bp) from 19 Javan leopards, and hindcasted leopard distribution to the Pleistocene to gain further insights into the evolutionary history of the Javan leopard. Our data confirmed that Javan leopards are evolutionarily distinct from other Asian leopards, and that they have been present on Java since the Middle Pleistocene. Species distribution projections suggest that Java was likely colonized via a Malaya-Java land bridge that by-passed Sumatra, as suitable conditions for leopards during Pleistocene glacial periods were restricted to northern and western Sumatra. As fossil evidence supports the presence of leopards on Sumatra at the beginning of the Late Pleistocene, our projections are consistent with a scenario involving the extinction of leopards on Sumatra as a consequence of the Toba super volcanic eruption (similar to 74kya). The impact of this eruption was minor on Java, suggesting that leopards managed to survive here. Currently, only a few hundred leopards still live in the wild and only about 50 are managed in captivity. Therefore, this unique and distinctive subspecies requires urgent, concerted conservation efforts, integrating insitu and ex situ conservation management activities in a One Plan Approach to species conservation management.
Since 1998, elite athletes’ sport injuries have been monitored in single sport event, which leads to the development of first comprehensive injury surveillance system in multi-sport Olympic Games in 2008. However, injury and illness occurred in training phases have not been systematically studied due to its multi-facets, potentially interactive risk related factors. The present thesis aim to address issues of feasibility of establishing a validated measure for injury/illness, training environment and psychosocial risk factors by creating the evaluation tool namely risk of injury questionnaire (Risk-IQ) for elite athletes, which based on IOC consensus statement 2009 recommended content of preparticipation evaluation(PPE) and periodic health exam (PHE).
A total of 335 top level athletes and a total of 88 medical care providers from Germany and Taiwan participated in tow “cross-sectional plus longitudinal” Risk-IQ and MCPQ surveys respectively. Four categories of injury/illness related risk factors questions were asked in Risk-IQ for athletes while injury risk and psychological related questions were asked in MCPQ for MCP cohorts. Answers were quantified scales wise/subscales wise before analyzed with other factors/scales. In addition, adapted variables such as sport format were introduced for difference task of analysis.
Validated with 2-wyas translation and test-retest reliabilities, the Risk-IQ was proved to be in good standard which were further confirmed by analyzed results from official surveys in both Germany and Taiwan. The result of Risk-IQ revealed that elite athletes’ accumulated total injuries, in general, were multi-factor dependent; influencing factors including but not limited to background experiences, medical history, PHE and PPE medical resources as well as stress from life events. Injuries of different body parts were sport format and location specific. Additionally, medical support of PPE and PHE indicated significant difference between German and Taiwan.
The result of the present thesis confirmed that it is feasible to construct a comprehensive evalua-tion instrument for heterogeneous elite athletes cohorts’ risk factor analysis for injury/illness oc-curred during their non-competition periods. In average and with many moderators involved, Ger-man elite athletes have superior medical care support yet suffered more severe injuries than Tai-wanese counterparts. Opinions of injury related psychological issues reflected differently on vari-ous MCP groups irrespective of different nationalities. In general, influencing factors and interac-tions existed among relevant factors in both studies which implied further investigation with multiple regression analysis is needed for better understanding.
The determination of the total carbon storage of peatlands is of high relevance in the context of climate-change mitigation efforts. This determination relies on data about stratigraphy and peat properties, which are conventionally collected by coring. Ground-penetrating radar (GPR) and electrical resistivity imaging (ERI) can support these point data by providing subsoil information in two-dimensional cross-sections. In this study, GPR and ERI were conducted at two groundwater-fed fen sites located in the temperate zone in north-east Germany. The fens of this region are embedded in low conductive glacial sand and are characterised by thick layers of gyttja, which can be either mineral or organic. The two study sites are representative of this region with respect to stratigraphy (total thickness, peat and gyttja types) and ecological conditions (pH-value, trophic condition). The aim of this study is to assess the suitability of GPR and ERI to detect stratigraphy and peat properties under these characteristic site conditions. Results show that GPR clearly detects the interfaces between (i) Carex and brown-moss peat, (ii) brown-moss peat and organic gyttja, (iii) organic- and mineral gyttja, and (iv) mineral gyttja and the parent material (glacial sand). These layers differ in bulk density and the related organic matter content. ERI, however, does not delineate these layers; rather it delineates regions of varying properties. At our base-rich site, pore fluid conductivity and cation.exchange capacity are the main factors that determine peat electrical conductivity (reverse of resistivity), whereas organic matter and water content are most influential at the more acidic site. Thus the correlation between peat properties and electrical conductivity are driven by site-specific conditions, which are mainly determined by the solute load in the groundwater at fens. When the total organic deposits exceed a thickness of 5 m, the depth of investigation by GPR is limited due to increasing attenuation. This is not a limiting factor for ERI, where the transition from organic deposits to glacial sand is visible at both sites. Due to these specific sensitivities, a combined application of GPR and ERI meets the demand for up-to-date information on carbon storage of peatlands, which is, moreover, very site-specific because of the inherent variety of ecological conditions and stratigraphy between peatlands in general and between fens and bogs in particular. (C) 2016 Elsevier B.V. All rights reserved.
Hintergrund: Kraft und Schnelligkeit stellen bedeutsame leistungsdeterminierende Faktoren im Fußball dar. Durch Komplextraining (Kombination aus Kraft- und plyometrischen Übungen in einer Trainingseinheit) lassen sich Kraft- und Schnelligkeitswerte von Athleten steigern. Unklar ist jedoch, ob ein Komplextraining (KT) gegenüber einem herkömmlichen blockweisen Krafttraining (BT) zu größeren sportmotorischen Leistungssteigerungen führt. Das Ziel der Studie war es, die Effekte von KT versus BT auf Variablen der Kraft, Schnelligkeit und Gewandtheit von Nachwuchsleistungsfußballern zu untersuchen.
Methode: Zusätzlich zum regulären Fußballtraining (ca. 6 × pro Woche, je 60 – 90 min.) führten 18 männliche Nachwuchsleistungsfußballer über sechs Wochen (2 × pro Woche, je 30 min.) entweder ein progressives KT (n = 10, Alter: 18,5 ± 2,2 Jahre) oder BT (n = 8, Alter: 18,1 ± 1,6 Jahre) durch. Vor und nach dem Training wurden Tests zur Erfassung der Kraft (Einer-Wiederholungs-Maximum [EWM] Kniebeuge), der Sprungkraft (Hockstrecksprung [HSS]), der Schnelligkeit (30-m-Sprint) und der Gewandtheit (T-Test) durchgeführt. Es wurden parameterfreie Verfahren zur Bestimmung von Unterschieden innerhalb (Wilcoxon-Test) und zwischen (Mann-Whitney-U-Test) den beiden Gruppen gerechnet.
Ergebnisse: Sowohl KT als auch BT sind sichere (keine trainings- aber sechs spielbedingte Verletzungen) und geeignete (Trainingsteilnahme in KT und BT: ≥ 80 %) Trainingsmaßnahmen in Ergänzung zum regulären Fußballtraining. Die statistische Analyse ergab signifikante Verbesserungen vom Prä- zum Posttest für die KT-Gruppe im EWM (p = 0,043) und im HSS (p = 0,046) sowie für die BT-Gruppe in der Sprintzeit über 5 m (p = 0,039) und 10 m (p = 0,026). Zudem zeigten sich für beide Gruppen signifikante Verbesserungen im T-Test (KT: p = 0,046; BT: p = 0,027). Der Gruppenvergleich (KT vs. BT) über die Zeit (Post- minus Prätest) offenbarte keine bedeutsamen Unterschiede.
Schlussfolgerung: Sowohl sechswöchiges KT als auch BT führten zu signifikanten Verbesserungen sportmotorischer Leistungen bei Nachwuchsleistungsfußballern. Allerdings konnten keine zusätzlich leistungssteigernden Effekte von KT im Vergleich zu BT ermittelt werden. In zukünftigen Studien sollte geprüft werden, ob die beobachteten testspezifischen Veränderungen, d. h. Verbesserung der Kraft/Sprungkraft in der KT-Gruppe und Verbesserung der Schnelligkeit in der BT-Gruppe der gewählten Übungsanordnung geschuldet sind oder einen generellen Effekt darstellen.
Background: Muscle strength and speed are important determinants of soccer performance. It has previously been shown that complex training (CT, combination of strength and plyometric exercises within a single training session) is effective to enhance strength and speed performance in athletes. However, it is unresolved whether CT is more effective than conventional strength training that is delivered in one single block (BT) to increase proxies of athletic performance. Thus, the aim of the present study was to investigate the effects of CT versus BT on measures of muscle strength/power, speed, and agility in elite youth soccer players. Methods: Eighteen male elite youth soccer players conducted six weeks (2 sessions/week, 30 min, each) of progressive CT (n = 10, age: 18,5 +/- 2.2 years) or BT (n=8, age: 18.1 +/- 1.6 years) in addition to their regular soccer training (approx. 6 sessions/week, 60-90 min, each). Before and after training, tests were conducted for the assessment of strength (one -repetition maximum [1RM] squat), power (countermovement jump [CMJ]), speed (30-m linear sprint), and agility (T test). Non-parametric analyses were used to calculate differences within (Wilcoxon test) and between (Mann-Whitney-U test) groups. Results: Both CT and BT proved to be safe (i.e. no training-related, but six match -related injuries reported) and feasible (i.e. attendance rate of 80% in both groups) training regimens when implemented in addition to regular soccer training. The statistical analysis revealed significant improvements from pre-training to post-training tests for the CT group in 1 RM squat (p =0.043) and CMJ height (p =0,046). For the BT -group, significantly enhanced sprint times were observed over 5 m (p = 0.039) and 10 m (p = 0.026), Furthermore, both groups significantly improved their t test time (CT: p =0.046; BT: p =0.027). However, group comparisons (CT vs. BT) over time (post-training minus pre-training test) did not show any significant differences. Conclusion: Six weeks of CT and BT resulted in significant improvements in proxies of athletic performance. Yet CT did not produce any additional effects compared to BT. Future research is needed to examine whether the observed test-specific changes, i.e. improvements in strength/power for the CT-group and improvements in speed for the BT-group, are due to the applied configuration of strength, plyometric, and sprint exercises or if they rather indicate a general training response.
Improved measurements of the photospheric and chromospheric three-dimensional magnetic and flow fields are crucial for a precise determination of the origin and evolution of active regions. We present an illustrative sample of multi-instrument data acquired during a two-week coordinated observing campaign in August 2015 involving, among others, the GREGOR solar telescope (imaging and near-infrared spectroscopy) and the space missions Solar Dynamics Observatory (SDO) and Interface Region Imaging Spectrograph (IRIS). The observations focused on the trailing part of active region NOAA 12396 with complex polarity inversion lines and strong intrusions of opposite polarity flux. The GREGOR Infrared Spectrograph (GRIS) provided Stokes IQUV spectral profiles in the photospheric Si i.1082.7 nm line, the chromospheric He I lambda 1083.0 nm triplet, and the photospheric Ca I lambda 1083.9 nm line. Carefully calibrated GRIS scans of the active region provided maps of Doppler velocity and magnetic field at different atmospheric heights. We compare quick-look maps with those obtained with the " Stokes Inversions based on Response functions" (SIR) code, which furnishes deeper insight into the magnetic properties of the region. We find supporting evidence that newly emerging flux and intruding opposite polarity flux are hampering the formation of penumbrae, i.e., a penumbra fully surrounding a sunspot is only expected after cessation of flux emergence in proximity to the sunspots. (C) 2016 WILEY-VCH Verlag GmbH& Co.KGaA, Weinheim