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Ein Dach über Europa
(2022)
Wo ist Deutschlands Raketenabwehr? Diese Frage rückte nach der völkerrechtswidrigen Annexion der Krim durch Russland 2014 in den Fokus der Presseberichterstattung. Für die Abwehr von ballistischen Raketen ist die Flugabwehrraketentruppe der Luftwaffe zuständig. Im Ost-West-Konflikt schützten rund 18.600 deutsche Soldaten im Rahmen der Integrierten NATO-Luftverteidigung die westliche Allianz vor Luftangriffen durch den Warschauer Pakt. Nach der Wiedervereinigung befand sich der Luftverteidigungsgürtel des Bündnisses nicht nur in einer geografisch wirkungslosen Position, sondern ihm fehlte auch die Daseinsberechtigung. Mit seiner Auflösung ging ein erheblicher Abbau von Personal und Material der Flugabwehrraketenverbände einher. Nach der Neuausrichtung der Bundeswehr 2012 blieb diesem Dienstbereich der Luftwaffe nur noch ein Geschwader mit rund 2.300 Dienstposten. Der alte Feind war weg – und Deutschland nach 1989/90 umgeben von Freunden und Verbündeten. Warum also sollte die Regierung in eine Fähigkeit investieren, die Deutschland für sich selbst nicht brauchte?
E-Learning Symposium 2018
(2018)
Keil, Reinhard ; Konert, Johannes ; Damnik, Gregor ; Gierl, Mark J. ; Proske, Antje ; Körndle, Hermann ; Narciss, Susanne ; Wahl, Marina ; Hölscher, Michael ; Mariani, Ennio ; Jaisli, Isabel ; Tscherejkina, Anna ; Morgiel, Anna ; Moebert, Tobias ; Herbstreit, Stephanie ; Mäker, Daniela ; Szalai, Cynthia ; Braun, Iris ; Kapp, Felix ; Hara, Tenshi C. ; Kubica, Tommy ; Stumpf, Sarah
In den vergangenen Jahren sind viele E-Learning-Innovationen entstanden. Einige davon wurden auf den vergangenen E-Learning Symposien der Universität Potsdam präsentiert: Das erste E-Learning Symposium im Jahr 2012 konzentrierte sich auf unterschiedliche Möglichkeiten der Studierendenaktivierung und Lehrgestaltung. Das Symposium 2014 rückte vor allem die Studierenden ins Zentrum der Aufmerksamkeit. Im Jahr 2016 kam es durch das Zusammengehen des Symposiums mit der DeLFI-Tagung zu einer Fokussierung auf technische Innovationen. Doch was ist aus den Leuchttürmen von gestern geworden, und brauchen wir überhaupt noch neue Leuchttürme? Das Symposium setzt sich in diesem Jahr unter dem Motto „Innovation und Nachhaltigkeit – (k)ein Gegensatz?“ mit mediengestützten Lehr- und Lernprozessen im universitären Kontext auseinander und reflektiert aktuelle technische sowie didaktische Entwicklungen mit Blick auf deren mittel- bis langfristigen Einsatz in der Praxis.
Dieser Tagungsband zum E-Learning Symposium 2018 an der Universität Potsdam beinhaltet eine Mischung von Forschungs- und Praxisbeiträgen aus verschiedenen Fachdisziplinen und eröffnet vielschichtige Perspektiven auf das Thema E-Learning. Dabei werden die Vielfalt der didaktischen Einsatzszenarien als auch die Potentiale von Werk-zeugen und Methoden der Informatik in ihrem Zusammenspiel beleuchtet.
In seiner Keynote widmet sich Reinhard Keil dem Motto des Symposiums und geht der Nachhaltigkeit bei E-Learning-Projekten auf den Grund. Dabei analysiert und beleuchtet er anhand seiner über 15-jährigen Forschungspraxis die wichtigsten Wirkfaktoren und formuliert Empfehlungen zur Konzeption von E-Learning-Projekten. Im Gegensatz zu rein auf Kostenersparnis ausgerichteten (hochschul-)politischen Forderungen proklamiert er den Ansatz der hypothesengeleiteten Technikgestaltung, in der Nachhaltigkeit als Leitfrage oder Forschungsstrategie verstanden werden kann. In eine ähnliche Richtung geht der Beitrag von Iris Braun et al., die über Erfolgsfaktoren beim Einsatz von Audience Response Systemen in der universitären Lehre berichten.
Ein weiteres aktuelles Thema, sowohl für die Bildungstechnologie als auch in den Bildungswissenschaften allgemein, ist die Kompetenzorientierung und –modellierung. Hier geht es darum (Problemlöse-)Fähigkeiten gezielt zu beschreiben und in den Mittelpunkt der Lehre zu stellen. Johannes Konert stellt in einem eingeladenen Vortrag zwei Projekte vor, die den Prozess beginnend bei der Definition von Kompetenzen, deren Modellierung in einem semantischen maschinenlesbaren Format bis hin zur Erarbeitung von Methoden zur Kompetenzmessung und der elektronischen Zertifizierung aufzeigen. Dabei geht er auf technische Möglichkeiten, aber auch Grenzen ein. Auf einer spezifischeren Ebene beschäftigt sich Sarah Stumpf mit digitalen bzw. mediendidaktischen Kompetenzen im Lehramtsstudium und stellt ein Framework für die Förderung ebensolcher Kompetenzen bei angehenden Lehrkräften vor.
Der Einsatz von E-Learning birgt noch einige Herausforderungen. Dabei geht es oft um die Verbindung von Didaktik und Technik, den Erhalt von Aufmerksamkeit oder den Aufwand für das Erstellen von interaktiven Lehr- und Lerninhalten. Drei Beiträge in diesem Tagungsband beschäftigen sich mit dieser Thematik in unterschiedlichen Kontexten und zeigen Best-Practices und Lösungsansätze auf: Der Beitrag von Martina Wahl und Michael Hölscher behandelt den besonderen Kontext von Blended Learning-Szenarien in berufsbegleitenden Studiengängen. Um die Veröffentlichung eines global frei verfügbaren Onlinekurses abseits der großen MOOC Plattformen und den didaktischen Herausforderungen auch hinsichtlich der Motivation geht es im Beitrag von Ennio Marani und Isabel Jaisli. Schließlich schlagen Gregor Damnik et al. die automatische Erzeugung von Aufgaben zur Erhöhung von Interaktivität und Adaptivität in digitalen Lernressourcen vor, um den teilweise erheblichen Erstellungsaufwand zu reduzieren.
Zum Thema E-Learning zählen auch immer mobile Apps bzw. Spiele. Gleich zwei Beiträge beschäftigen sich mit dem Einsatz von E-Learning-Tools im Gesundheitskontext: Anna Tscherejkina und Anna Morgiel stellen in ihrem Beitrag Minispiele zum Training von sozio-emotionalen Kompetenzen für Menschen mit Autismus vor, und Stephanie Herbstreit et al. berichten vom Einsatz einer mobilen Lern-App zur Verbesserung von klinisch-praktischem Unterricht.
Troll, K. ; Kulkarni, Amit ; Wang, W. ; Darko, C. ; Koumba, A. M. Bivigou ; Laschewsky, André ; Müller-Buschbaum, Peter ; Papadakis, Christine M.
Cordeiro, Andre M. ; Andrade, Luis ; Monteiro, Catarina C. ; Leitao, Guilherme ; Wigge, Philip Anthony ; Saibo, Nelson J. M.
Review exploring the regulation of PHYTOCHROME-INTERACTING FACTORS by light, their role in abiotic stress tolerance and plant architecture, and their influence on crop productivity.
Light is a key determinant for plant growth, development, and ultimately yield. Phytochromes, red/far-red photoreceptors, play an important role in plant architecture, stress tolerance, and productivity. In the model plant Arabidopsis, it has been shown that PHYTOCHROME-INTERACTING FACTORS (PIFs; bHLH transcription factors) act as central hubs in the integration of external stimuli to regulate plant development. Recent studies have unveiled the importance of PIFs in crops. They are involved in the modulation of plant architecture and productivity through the regulation of cell division and elongation in response to different environmental cues. These studies show that different PIFs have overlapping but also distinct functions in the regulation of plant growth. Therefore, understanding the molecular mechanisms by which PIFs regulate plant development is crucial to improve crop productivity under both optimal and adverse environmental conditions. In this review, we discuss current knowledge of PIFs acting as integrators of light and other signals in different crops, with particular focus on the role of PIFs in responding to different environmental conditions and how this can be used to improve crop productivity.
Sommer, C. ; Garbusow, Maria ; Juenger, E. ; Pooseh, S. ; Bernhardt, Nadine ; Birkenstock, J. ; Schad, Daniel ; Jabs, B. ; Gloeckler, T. ; Huys, Quentin J. M. ; Heinz, A. ; Smolka, Michael N. ; Zimmermann, Ulrich S.
Alcohol-related cues acquire incentive salience through Pavlovian conditioning and then can markedly affect instrumental behavior of alcohol-dependent patients to promote relapse. However, it is unclear whether similar effects occur with alcohol-unrelated cues. We tested 116 early-abstinent alcohol-dependent patients and 91 healthy controls who completed a delay discounting task to assess choice impulsivity, and a Pavlovian-to-instrumental transfer (PIT) paradigm employing both alcohol-unrelated and alcohol-related stimuli. To modify instrumental choice behavior, we tiled the background of the computer screen either with conditioned stimuli (CS) previously generated by pairing abstract pictures with pictures indicating monetary gains or losses, or with pictures displaying alcohol or water beverages. CS paired to money gains and losses affected instrumental choices differently. This PIT effect was significantly more pronounced in patients compared to controls, and the group difference was mainly driven by highly impulsive patients. The PIT effect was particularly strong in trials in which the instrumental stimulus required inhibition of instrumental response behavior and the background CS was associated to monetary gains. Under that condition, patients performed inappropriate approach behavior, contrary to their previously formed behavioral intention. Surprisingly, the effect of alcohol and water pictures as background stimuli resembled that of aversive and appetitive CS, respectively. These findings suggest that positively valenced background CS can provoke dysfunctional instrumental approach behavior in impulsive alcohol-dependent patients. Consequently, in real life they might be easily seduced by environmental cues to engage in actions thwarting their long-term goals. Such behaviors may include, but are not limited to, approaching alcohol.
Tadjoung Waffo, Armel Franklin ; Yesildag, Cigdem ; Caserta, Giorgio ; Katz, Sagie ; Zebger, Ingo ; Lensen, Marga C. ; Wollenberger, Ulla ; Scheller, Frieder W. ; Altintas, Zeynep
This study aims to develop a rapid, sensitive and cost-effective biomimetic electrochemical sensor for artemisinin determination in plant extracts and for pharmacokinetic studies. A novel molecularly imprinted polymer (MIP)based electrochemical sensor was developed by electropolymerization of o-phenylenediamine (o-PD) in the presence of artemisinin on gold wire surface for sensitive detection of artemisinin. The experimental parameters, including selection of functional monomer, polymerization conditions, template extraction after polymerization, influence of pH and buffer were all optimized. Every step of imprinted film synthesis were evaluated by employing voltammetry techniques, surface-enhanced infrared absorption spectroscopy (SEIRAS) and atomic force microscopy (AFM). The specificity was further evaluated by investigating non-specific artemisinin binding on non-imprinted polymer (NIP) surfaces and an imprinting factor of 6.8 was achieved. The artemisinin imprinted polymers using o-PD as functional monomer have provided highly stable and effective binding cavities for artemisinin. Cross-reactivity studies with drug molecules showed that the MIPs are highly specific for artemisinin. The influence of matrix effect was further investigated both in artificial plant matrix and diluted human serum. The results revealed a high affinity of artemisinin-MIP with dissociation constant of 7.3 x 10(-9) M and with a detection limit of 0.01 mu M and 0.02 mu M in buffer and plant matrix, respectively.
McNulty, Margaret A. ; Goupil, Brad A. ; Albarado, Diana C. ; Castaño-Martinez, Teresa ; Ambrosi, Thomas H. ; Puh, Spela ; Schulz, Tim Julius ; Schürmann, Annette ; Morrison, Christopher D. ; Laeger, Thomas
Background: Dietary protein restriction is emerging as an alternative approach to treat obesity and glucose intolerance because it markedly increases plasma fibroblast growth factor 21 (FGF21) concentrations. Similarly, dietary restriction of methionine is known to mimic metabolic effects of energy and protein restriction with FGF21 as a required mechanism. However, dietary protein has been shown to be required for normal bone growth, though there is conflicting evidence as to the influence of dietary protein restriction on bone remodeling. The purpose of the current study was to evaluate the effect of dietary protein and methionine restriction on bone in lean and obese mice, and clarify whether FGF21 and general control nonderepressible 2 (GCN2) kinase, that are part of a novel endocrine pathway implicated in the detection of protein restriction, influence the effect of dietary protein restriction on bone.
Methods: Adult wild-type (WT) or Fgf21 KO mice were fed a normal protein (18 kcal%; CON) or low protein (4 kcal%; LP) diet for 2 or 27 weeks. In addition, adult WT or Gcn2 KO mice were fed a CON or LP diet for 27 weeks. Young New Zealand obese (NZO) mice were placed on high-fat diets that provided protein at control (16 kcal%; CON), low levels (4 kcal%) in a high-carbohydrate (LP/HC) or high-fat (LP/HF) regimen, or on high-fat diets (protein, 16 kcal%) that provided methionine at control (0.86%; CON-MR) or low levels (0.17%; MR) for up to 9 weeks. Long bones from the hind limbs of these mice were collected and evaluated with micro-computed tomography (mu CT) for changes in trabecular and cortical architecture and mass.
Results: In WT mice the 27-week LP diet significantly reduced cortical bone, and this effect was enhanced by deletion of Fgf21 but not Gcn2. This decrease in bone did not appear after 2 weeks on the LP diet. In addition, Fgf21 KO mice had significantly less bone than their WT counterparts. In obese NZO mice dietary protein and methionine restriction altered bone architecture. The changes were mediated by FGF21 due to methionine restriction in the presence of cystine, which did not increase plasma FGF21 levels and did not affect bone architecture.
Conclusions: This study provides direct evidence of a reduction in bone following long-term dietary protein restriction in a mouse model, effects that appear to be mediated by FGF21.
Estimating global mean sea-level rise and its uncertainties by 2100 and 2300 from an expert survey
(2020)
Horton, Benjamin P. ; Khan, Nicole S. ; Cahill, Niamh ; Lee, Janice S. H. ; Shaw, Timothy A. ; Garner, Andra J. ; Kemp, Andrew C. ; Engelhart, Simon E. ; Rahmstorf, Stefan
Sea-level rise projections and knowledge of their uncertainties are vital to make informed mitigation and adaptation decisions. To elicit projections from members of the scientific community regarding future global mean sea-level (GMSL) rise, we repeated a survey originally conducted five years ago. Under Representative Concentration Pathway (RCP) 2.6, 106 experts projected a likely (central 66% probability) GMSL rise of 0.30-0.65 m by 2100, and 0.54-2.15 m by 2300, relative to 1986-2005. Under RCP 8.5, the same experts projected a likely GMSL rise of 0.63-1.32 m by 2100, and 1.67-5.61 m by 2300. Expert projections for 2100 are similar to those from the original survey, although the projection for 2300 has extended tails and is higher than the original survey. Experts give a likelihood of 42% (original survey) and 45% (current survey) that under the high-emissions scenario GMSL rise will exceed the upper bound (0.98 m) of the likely range estimated by the Fifth Assessment Report of the Intergovernmental Panel on Climate Change, which is considered to have an exceedance likelihood of 17%. Responses to open-ended questions suggest that the increases in upper-end estimates and uncertainties arose from recent influential studies about the impact of marine ice cliff instability on the meltwater contribution to GMSL rise from the Antarctic Ice Sheet.
Hoke, Gregory D. ; Garzione, Carmala N. ; Araneo, Diego C. ; Latorre, Claudio ; Strecker, Manfred ; Williams, Kendra J.
Stable isotope altimetry is a useful tool for estimating paleoelevation in sedimentary records. Yet questions remain regarding how source moisture, climate, and local topography can influence these estimates. Here we present stable isotope altimetry results on late Quaternary pedogenic carbonates of known elevation on both flanks of the Andean orogen at 33 degrees S. We measured delta O-18 values of pedogenic carbonates and river water samples from small drainages at regular elevation increments within the Rio Aconcagua (Chile) and Rio Mendoza (Argentina) catchments. The delta O-18 values of river waters correlate well with elevation and show similar isotopic gradients between the Chilean (-3.7 parts per thousand/km) and Argentine (-4.8 parts per thousand/km) sides of the range. Uncertainties associated with scatter in the river water data and assumptions about the temperature of carbonate formation indicate that elevation estimates have 1 sigma errors of 350-450 m. We estimate the isotopic composition of soil water from pedogenic carbonates on both sides of the range by assuming mean annual temperatures based the modern temperature lapse rate from meteorological station data. Combined, our data show that stable isotope altimetry produces reasonable estimates of modern elevation, with the majority of our samples (60%) within the 1 sigma uncertainties and 77% within 2 sigma.
McNulty, Margaret A. ; Goupil, Brad A. ; Albarado, Diana C. ; Castaño-Martinez, Teresa ; Ambrosi, Thomas H. ; Puh, Spela ; Schulz, Tim Julius ; Schürmann, Annette ; Morrison, Christopher D. ; Laeger, Thomas
Background: Dietary protein restriction is emerging as an alternative approach to treat obesity and glucose intolerance because it markedly increases plasma fibroblast growth factor 21 (FGF21) concentrations. Similarly, dietary restriction of methionine is known to mimic metabolic effects of energy and protein restriction with FGF21 as a required mechanism. However, dietary protein has been shown to be required for normal bone growth, though there is conflicting evidence as to the influence of dietary protein restriction on bone remodeling. The purpose of the current study was to evaluate the effect of dietary protein and methionine restriction on bone in lean and obese mice, and clarify whether FGF21 and general control nonderepressible 2 (GCN2) kinase, that are part of a novel endocrine pathway implicated in the detection of protein restriction, influence the effect of dietary protein restriction on bone.
Methods: Adult wild-type (WT) or Fgf21 KO mice were fed a normal protein (18 kcal%; CON) or low protein (4 kcal%; LP) diet for 2 or 27 weeks. In addition, adult WT or Gcn2 KO mice were fed a CON or LP diet for 27 weeks. Young New Zealand obese (NZO) mice were placed on high-fat diets that provided protein at control (16 kcal%; CON), low levels (4 kcal%) in a high-carbohydrate (LP/HC) or high-fat (LP/HF) regimen, or on high-fat diets (protein, 16 kcal%) that provided methionine at control (0.86%; CON-MR) or low levels (0.17%; MR) for up to 9 weeks. Long bones from the hind limbs of these mice were collected and evaluated with micro-computed tomography (mu CT) for changes in trabecular and cortical architecture and mass.
Results: In WT mice the 27-week LP diet significantly reduced cortical bone, and this effect was enhanced by deletion of Fgf21 but not Gcn2. This decrease in bone did not appear after 2 weeks on the LP diet. In addition, Fgf21 KO mice had significantly less bone than their WT counterparts. In obese NZO mice dietary protein and methionine restriction altered bone architecture. The changes were mediated by FGF21 due to methionine restriction in the presence of cystine, which did not increase plasma FGF21 levels and did not affect bone architecture.
Conclusions: This study provides direct evidence of a reduction in bone following long-term dietary protein restriction in a mouse model, effects that appear to be mediated by FGF21.
del Papa, C. ; Hongn, Fernando D. ; Powell, J. ; Payrola, P. ; Do Campo, M. ; Strecker, Manfred ; Petrinovic, I. ; Schmitt, A. K. ; Pereyra, R.
Two end-member models have been proposed for the Paleogene Andean foreland: a simple W-E migrating foreland model and a broken-foreland model. We present new stratigraphic, sedimentological and structural data from the Paleogene Quebrada de los Colorados (QLC) Formation, in the Eastern Cordillera, with which to test these two different models. Basin-wide unconformities, growthstrata and changes in provenance indicate deposition of the QLC Formation in a tectonically active basin. Both west- and east-vergent structures, rooted in the basement, controlled the deposition and distribution of the QLC Formation from the Middle Eocene to the Early Miocene. The provenance analysis indicates that the main source areas were basement blocks, like the Paleozoic Oire Eruptive Complex, uplifted during Paleogene shortening, and that delimits the eastern boundary of the present-day intraorogenic Puna plateau. A comparison of the QLC sedimentary basin-fill pattern with those of adjacent Paleogene basins in the Puna plateau and in the Santa Barbara System highlights the presence of discrete depozones. These reflect the early compartmentalization of the foreland, rather than a stepwise advance of the deformation front of a thrust belt. The early Tertiary foreland of the southern central Andes is represented by a ca. 250-km-wide area comprising several deformation zones (Arizaro, Macon, Copalayo and Calchaqui) in which doubly vergent or asymmetric structures, rooted in the basement, were generated. Hence, classical foreland model is difficult to apply in this Paleogene basin; and our data and interpretation agree with a broken-foreland model.
Deng, Zijun ; Wang, Weiwei ; Xua, Xun ; Gould, Oliver E. C. ; Kratz, Karl ; Ma, Nan ; Lendlein, Andreas
Stem cells are capable of sensing and processing environmental inputs, converting this information to output a specific cell lineage through signaling cascades. Despite the combinatorial nature of mechanical, thermal, and biochemical signals, these stimuli have typically been decoupled and applied independently, requiring continuous regulation by controlling units. We employ a programmable polymer actuator sheet to autonomously synchronize thermal and mechanical signals applied to mesenchymal stem cells (MSC5). Using a grid on its underside, the shape change of polymer sheet, as well as cell morphology, calcium (Ca2+) influx, and focal adhesion assembly, could be visualized and quantified. This paper gives compelling evidence that the temperature sensing and mechanosensing of MSC5 are interconnected via intracellular Ca2+. Up-regulated Ca2+ levels lead to a remarkable alteration of histone H3K9 acetylation and activation of osteogenic related genes. The interplay of physical, thermal, and biochemical signaling was utilized to accelerate the cell differentiation toward osteogenic lineage. The approach of programmable bioinstructivity provides a fundamental principle for functional biomaterials exhibiting multifaceted stimuli on differentiation programs. Technological impact is expected in the tissue engineering of periosteum for treating bone defects.
Estimating global mean sea-level rise and its uncertainties by 2100 and 2300 from an expert survey
(2020)
Horton, Benjamin P. ; Khan, Nicole S. ; Cahill, Niamh ; Lee, Janice S. H. ; Shaw, Timothy A. ; Garner, Andra J. ; Kemp, Andrew C. ; Engelhart, Simon E. ; Rahmstorf, Stefan
Sea-level rise projections and knowledge of their uncertainties are vital to make informed mitigation and adaptation decisions. To elicit projections from members of the scientific community regarding future global mean sea-level (GMSL) rise, we repeated a survey originally conducted five years ago. Under Representative Concentration Pathway (RCP) 2.6, 106 experts projected a likely (central 66% probability) GMSL rise of 0.30-0.65 m by 2100, and 0.54-2.15 m by 2300, relative to 1986-2005. Under RCP 8.5, the same experts projected a likely GMSL rise of 0.63-1.32 m by 2100, and 1.67-5.61 m by 2300. Expert projections for 2100 are similar to those from the original survey, although the projection for 2300 has extended tails and is higher than the original survey. Experts give a likelihood of 42% (original survey) and 45% (current survey) that under the high-emissions scenario GMSL rise will exceed the upper bound (0.98 m) of the likely range estimated by the Fifth Assessment Report of the Intergovernmental Panel on Climate Change, which is considered to have an exceedance likelihood of 17%. Responses to open-ended questions suggest that the increases in upper-end estimates and uncertainties arose from recent influential studies about the impact of marine ice cliff instability on the meltwater contribution to GMSL rise from the Antarctic Ice Sheet.
Schildgen, Taylor F. ; Cosentino, D. ; Bookhagen, Bodo ; Niedermann, Samuel ; Yildirim, C. ; Echtler, Helmut Peter ; Wittmann, Hella ; Strecker, Manfred
Uplifted Neogene marine sediments and Quaternary fluvial terraces in the Mut Basin, southern Turkey, reveal a detailed history of surface uplift along the southern margin of the Central Anatolian plateau from the Late Miocene to the present. New surface exposure ages (Be-10, Al-26, and Ne-21) of gravels capping fluvial strath terraces located between 28 and 135 m above the Goksu River in the Mut Basin yield ages ranging from ca. 25 to 130 ka, corresponding to an average incision rate of 0.52 to 0.67 mm/yr. Published biostratigraphic data combined with new interpretations of the fossil assemblages from uplifted marine sediments reveal average uplift rates of 0.25 to 0.37 mm/yr since Late Miocene time (starting between 8 and 5.45 Ma), and 0.72 to 0.74 mm/yr after 1.66 to 1.62 Ma. Together with the terrace abandonment ages, the data imply 0.6 to 0.7 mm/yr uplift rates from 1.6 Ma to the present. The different post-Late Miocene and post-1.6 Ma uplift rates can imply increasing uplift rates through time, or multi-phased uplift with slow uplift or subsidence in between. Longitudinal profiles of rivers in the upper catchment of the Mut and Ermenek basins show no apparent lithologic or fault control on some knickpoints that occur at 1.2 to 1.5 km elevation, implying a transient response to a change in uplift rates. Projections of graded upper relict channel segments to the modern outlet, together with constraints from uplifted marine sediments, show that a slower incision/uplift rate of 0.1 to 0.2 mm/yr preceded the 0.7 mm/yr uplift rate. The river morphology and profile projections therefore reflect multi-phased uplift of the plateau margin, rather than steadily increasing uplift rates. Multi-phased uplift can be explained by lithospheric slab break-off and possibly also the arrival of the Eratosthenes Seamount at the collision zone south of Cyprus.
Schildgen, Taylor F. ; Cosentino, D. ; Caruso, A. ; Buchwaldt, Robert ; Yildirim, C. ; Bowring, S. A. ; Rojay, B. ; Echtler, Helmut Peter ; Strecker, Manfred
The southwest margin of the Central Anatolian Plateau has experienced multiple phases of topographic growth, including the formation of localized highs prior to the Late Miocene that were later affected by wholesale uplift of the plateau margin. Our new biostratigraphic data limit the age of uplifted marine sediments at the southwest plateau margin at 1.5 km elevation to <7.17 Ma, and regional lithostratigraphic correlations imply that the age is <6.7 Ma. Single-grain CA-TIMS U-Pb zircon analyses from a reworked ash within the marine sediments yield dates as young as 10.6 Ma, indicating a maximum age that is consistent with the biostratigraphy. Our structural measurements within the uplifted region and fault inversion modeling agree with previous findings in surrounding regions, with early contraction followed by strike-slip and extensional deformation during uplift. Focal mechanisms from shallow earthquakes show that the extensional phase has continued to the present. Broad similarities in the change in the tectonic stress regime (after 8 Ma) and the onset of surface uplift (after 7 Ma) imply that deep-seated process(es) caused post-7 Ma uplift. The geometry of lithospheric slabs beneath the plateau margin, Pliocene to recent alkaline volcanism, and the uplift pattern with accompanying normal faulting point toward slab tearing and localized heating at the base of the lithosphere as a probable mechanism for post-7 Ma uplift of the southwest margin. Considering previous work in the region, there appears to be an important link between slab dynamics and surface uplift throughout the Anatolian Plateau’s southern margin.
The Cenozoic East African Rift System (EARS) is an exceptional example of active continental extension, providing opportunities for furthering our understanding of hydrocarbon plays within rifts. It is divided into structurally distinct western and eastern branches. The western branch comprises deep rift basins separated by transfer zones, commonly localised onto pre-existing structures, offering good regional scale hydrocarbon traps. At a basin-scale, local discrete inherited structures might also play an important role on fault localisation and hydrocarbon distribution. Here, we consider the evolution of the Central basin of the Malawi Rift, in particular the influence of pre-existing structural fabrics. Integrating basin-scale multichannel 2D, and high resolution seismic datasets we constrain the border, Mlowe-Nkhata, fault system (MNF) to the west of the basin and smaller Mbamba fault (MF) to the east and document their evolution. Intra basin structures define a series of horsts, which initiated as convergent transfers, along the basin axis. The horsts are offset along a NE SW striking transfer fault parallel to and along strike of the onshore Karoo (Permo-Triassic) Ruhuhu graben. Discrete pre-existing structures probably determined its location and, oriented obliquely to the extension orientation it accommodated predominantly strike-slip deformation, with more slowly accrued dip-slip. To the north of this transfer fault, the overall basin architecture is asymmetric, thickening to the west throughout; while to the south, an initially symmetric graben architecture became increasingly asymmetric in sediment distribution as strain localised onto the western MNF. The presence of the axial horst increasingly focussed sediment supply to the west. As the transfer fault increased its displacement, so this axial supply was interrupted, effectively starving the south-east while ponding sediments between the western horst margin and the transfer fault. This asymmetric bathymetry and partitioned sedimentation continues to the present-day, overprinting the early basin symmetry and configuration. Sediments deposited earlier become increasingly dissected and fault juxtapositions changed at a small (10-100 m) scale. The observed influence of basin-scale transfer faults on sediment dispersal and fault compartmentalization due to pre-existing structures oblique to the extension orientation is relevant to analogous exploration settings. (C) 2016 Elsevier Ltd. All rights reserved.
We develop a model of optimal carbon taxation and redistribution taking into account horizontal equity concerns by considering heterogeneous energy efficiencies. By deriving first- and second-best rules for policy instruments including carbon taxes, transfers and energy subsidies, we then investigate analytically how horizontal equity is considered in the social welfare maximizing tax structure. We calibrate the model to German household data and a 30 percent emission reduction goal. Our results show that energy-intensive households should receive more redistributive resources than energy-efficient households if and only if social inequality aversion is sufficiently high. We further find that redistribution of carbon tax revenue via household-specific transfers is the first-best policy. Equal per-capita transfers do not suffer from informational problems, but increase mitigation costs by around 15 percent compared to the first- best for unity inequality aversion. Adding renewable energy subsidies or non-linear energy subsidies, reduces mitigation costs further without relying on observability of households’ energy efficiency.
Research on corporate entrepreneurship—venturing activities by established corporations—has received increasing scholarly attention. We employ bibliometric methods to analyze the literature on corporate entrepreneurship published over the last five decades. Based on the results of citation and co-citation analyses, we reveal central works in the field and how they are interconnected. We investigate the underlying intellectual structure of the field. Our findings provide evidence of the growing maturity and interdisciplinarity of corporate entrepreneurship and provide insight into research themes. We find that resource-based view and its extensions still remain the predominant theoretical perspectives in the field. Drawing on these findings, we suggest directions for future research.
Fox, Andrew J. ; Wakker, Bart P. ; Barger, Kathleen A. ; Hernandez, Audra K. ; Richter, Philipp ; Lehner, Nicolas ; Bland-Hawthorn, Joss ; Charlton, Jane C. ; Westmeier, Tobias ; Thom, Christopher ; Tumlinson, Jason ; Misawa, Toru ; Howk, J. Christopher ; Haffner, L. Matthew ; Ely, Justin ; Rodriguez-Hidalgo, Paola ; Kumari, Nimisha
Dynamic interactions between the two Magellanic Clouds have flung large quantities of gas into the halo of the Milky Way. The result is a spectacular arrangement of gaseous structures, including the Magellanic Stream, the Magellanic Bridge, and the Leading Arm (collectively referred to as the Magellanic System). In this third paper of a series studying the Magellanic gas in absorption, we analyze the gas ionization level using a sample of 69 Hubble Space Telescope/Cosmic Origins Spectrograph sightlines that pass through or within 30 degrees of the 21 cm emitting regions. We find that 81% (56/69) of the sightlines show UV absorption at Magellanic velocities, indicating that the total cross-section of the Magellanic System is approximate to 11,000 deg(2), or around one-quarter of the entire sky. Using observations of the Si III/Si II ratio together with Cloudy photoionization modeling, we calculate the total gas mass (atomic plus ionized) of the Magellanic System to be approximate to 2.0 x 10(9) M-circle dot (d/55 kpc)(2), with the ionized gas contributing around three times as much mass as the atomic gas. This is larger than the current-day interstellar H I mass of both Magellanic Clouds combined, indicating that they have lost most of their initial gas mass. If the gas in the Magellanic System survives to reach the Galactic disk over its inflow time of similar to 0.5-1.0 Gyr, it will represent an average inflow rate of similar to 3.7-6.7 M-circle dot yr(-1), potentially raising the Galactic star formation rate. However, multiple signs of an evaporative interaction with the hot Galactic corona indicate that the Magellanic gas may not survive its journey to the disk fully intact and will instead add material to (and cool) the corona.
Richter, Philipp ; Nuza, S. E. ; Fox, Andrew J. ; Wakker, Bart P. ; Lehner, N. ; Ben Bekhti, Nadya ; Fechner, Cora ; Wendt, Martin ; Howk, J. Christopher ; Muzahid, S. ; Ganguly, R. ; Charlton, Jane C.
Context. The Milky Way is surrounded by large amounts of diffuse gaseous matter that connects the stellar body of our Galaxy with its large-scale Local Group (LG) environment. Aims. To characterize the absorption properties of this circumgalactic medium (CGM) and its relation to the LG we present the so-far largest survey of metal absorption in Galactic high-velocity clouds (HVCs) using archival ultraviolet (UV) spectra of extragalactic background sources. The UV data are obtained with the Cosmic Origins Spectrograph (COS) onboard the Hubble Space Telescope (HST) and are supplemented by 21 cm radio observations of neutral hydrogen. Methods. Along 270 sightlines we measure metal absorption in the lines of Si II, Si III, C II, and C IV and associated H I 21 cm emission in HVCs in the velocity range vertical bar v(LSR)vertical bar = 100-500 km s(-1). With this unprecedented large HVC sample we were able to improve the statistics on HVC covering fractions, ionization conditions, small-scale structure, CGM mass, and inflow rate. For the first time, we determine robustly the angular two point correlation function of the high-velocity absorbers, systematically analyze antipodal sightlines on the celestial sphere, and compare the HVC absorption characteristics with that of damped Lyman alpha absorbers (DLAs) and constrained cosmological simulations of the LG (CLUES project).
Quantification of subsurface water fluxes based on the one dimensional solution to the heat transport equation depends on the accuracy of measured subsurface temperatures. The influence of temperature probe setup on the accuracy of vertical water flux calculation was systematically evaluated in this experimental study. Four temperature probe setups were installed into a sand box experiment to measure temporal highly resolved vertical temperature profiles under controlled water fluxes in the range of +/- 1.3 md(-1). Pass band filtering provided amplitude differences and phase shifts of the diurnal temperature signal varying with depth depending on water flux. Amplitude ratios of setups directly installed into the saturated sediment significantly varied with sand box hydraulic gradients. Amplitude ratios provided an accurate basis for the analytical calculation of water flow velocities, which matched measured flow velocities. Calculated flow velocities were sensitive to thermal properties of saturated sediment and to temperature sensor spacing, but insensitive to thermal dispersivity equal to solute dispersivity. Amplitude ratios of temperature probe setups indirectly installed into piezometer pipes were influenced by thermal exchange processes within the pipes and significantly varied with water flux direction only. Temperature time lags of small sensor distances of all setups were found to be insensitive to vertical water flux.
EC 22536-5304
(2021)
Helium-burning hot subdwarf stars of spectral types O and B (sdO/B) are thought to be produced through various types of binary interactions. The helium-rich hot subdwarf star EC 22536-5304 was recently found to be extremely enriched in lead. Here, we show that EC 22536-5304 is a binary star with a metal-poor subdwarf F-type (sdF) companion. We performed a detailed analysis of high-resolution SALT/HRS and VLT/UVES spectra, deriving metal abundances for the hot subdwarf, as well as atmospheric parameters for both components. Because we consider the contribution of the sdF star, the derived lead abundance for the sdOB, + 6.3 +/- 0.3 dex relative to solar, is even higher than previously thought. We derive T-eff = 6210 +/- 70 K, log g = 4.64 +/- 0.10, [FE/H] = - 1.95 +/- 0.04, and [alpha/Fe] = + 0.40 +/- 0.04 for the sdF component. Radial velocity variations, although poorly sampled at present, indicate that the binary system has a long orbital period of about 457 days. This suggests that the system was likely formed through stable Roche lobe overflow (RLOF). A kinematic analysis shows that EC 22536-5304 is on an eccentric orbit around the Galactic centre. This, as well as the low metallicity and strong alpha enhancement of the sdF-type companion, indicate that EC 22536-5304 is part of the Galactic halo or metal-weak thick disc. As the first long-period hot subdwarf binary at [FE/H] less than or similar to- 1, EC 22536-5304 may help to constrain the RLOF mechanism for mass transfer from low-mass, low-metallicity red giant branch (RGB) stars to main-sequence companions.
Peres, Tanara V. ; Eyng, Helena ; Lopes, Samantha C. ; Colle, Dirleise ; Goncalves, Filipe M. ; Venske, Debora K. R. ; Lopes, Mark W. ; Ben, Juliana ; Bornhorst, Julia ; Schwerdtle, Tanja ; Aschner, Michael A. ; Farina, Marcelo ; Prediger, Rui D. ; Leal, Rodrigo B.
Exposure to high manganese (Mn) levels may damage the basal ganglia, leading to a syndrome analogous to Parkinson's disease, with motor and cognitive impairments. The molecular mechanisms underlying Mn neurotoxicity, particularly during development, still deserve further investigation. Herein, we addressed whether early-life Mn exposure affects motor coordination and cognitive function in adulthood and potential underlying mechanisms. Male Wistar rats were exposed intraperitoneally to saline (control) or MnCl2 (5, 10 or 20 mg/kg/day) from post-natal day (PND) 8-12. Behavioral tests were performed on PND 60-65 and biochemical analysis in the striatum and hippocampus were performed on PND14 or PND70. Rats exposed to Mn (10 and 20 mg/kg) performed significantly worse on the rotarod test than controls indicating motor coordination and balance impairments. The object and social recognition tasks were used to evaluate short-term memory. Rats exposed to the highest Mn dose failed to recognize a familiar object when replaced by a novel object as well as to recognize a familiar juvenile rat after a short period of time. However, Mn did not alter olfactory discrimination ability. In addition, Mn-treated rats displayed decreased levels of non-protein thiols (e.g. glutathione) and increased levels of glial fibrillary acidic protein (GFAP) in the striatum. Moreover, Mn significantly increased hippocampal glutathione peroxidase (GPx) activity. These findings demonstrate that acute low-level exposure to Mn during a critical neurodevelopmental period causes cognitive and motor dysfunctions that last into adulthood, that are accompanied by alterations in antioxidant defense system in both the hippocampus and striatum. (C) 2015 Elsevier Inc. All rights reserved.
We analyzed published records of terrigenous dust flux from marine sediments off subtropical West Africa, the eastern Mediterranean Sea, and the Arabian Sea, and lake records from East Africa using statistical methods to detect trends, rhythms and events in Plio-Pleistocene African climate. The critical reassessment of the environmental significance of dust flux and lake records removes the apparent inconsistencies between marine vs. terrestrial records of African climate variability. Based on these results, major steps in mammalian and hominin evolution occurred during episodes of a wetter, but highly variable climate largely controlled by orbitally induced insolation changes in the low latitudes.
HESS J1943+213
(2018)
Archer, A. ; Benbow, Wystan ; Bird, Ralph ; Brose, Robert ; Buchovecky, M. ; Bugaev, V ; Cui, Wei ; Danie, M. K. ; Falcone, A. ; Feng, Qi ; Finley, John P. ; Flinders, A. ; Fortson, L. ; Furniss, Amy ; Gillanders, Gerard H. ; Huttens, M. ; Hanna, David ; Hervet, O. ; Holder, J. ; Hughes, G. ; Humensky, T. B. ; Johnson, Caitlin A. ; Kaaret, Philip ; Kar, P. ; Kelley-Hoskins, N. ; Kieda, David ; Krause, Maria ; Krennrich, F. ; Kumar, S. ; Lang, M. J. ; Lin, T. T. Y. ; McArthur, S. ; Moriarty, P. ; Mukherjee, Reshmi ; Nieto, Daniel ; Ong, R. A. ; Otte, A. N. ; Park, Nahee ; Petrashyk, A. ; Pohl, Martin ; Popkow, Alexis ; Pueschel, Elisa ; Quinn, J. ; Ragan, K. ; Reynold, P. T. ; Richards, Gregory T. ; Roache, E. ; Rulten, C. ; Sadeh, I ; Sembroski, G. H. ; Shahinyan, Karlen ; Tyler, J. ; Wakely, S. P. ; Weiner, O. M. ; Weinstein, A. ; Wells, R. M. ; Wilcox, P. ; Wilhelm, Alina ; Williams, David A. ; Brisken, W. F. ; Pontrelli, P.
HESS J1943+213 is a very high energy (VHE; > 100 GeV) gamma-ray source in the direction of the Galactic plane. Studies exploring the classification of the source are converging toward its identification as an extreme synchrotron BL Lac object. Here we present 38 hr of VERITAS observations of HESS J1943+213 taken over 2 yr. The source is detected with a significance of similar to 20 standard deviations, showing a remarkably stable flux and spectrum in VHE gamma-rays. Multifrequency Very Long Baseline Array (VLBA) observations of the source confirm the extended, jet-like structure previously found in the 1.6 GHz band with the European VLBI Network and detect this component in the 4.6 and 7.3 GHz bands. The radio spectral indices of the core and the jet and the level of polarization derived from the VLBA observations are in a range typical for blazars. Data from VERITAS, Fermi-LAT, Swift-XRT, the FLWO 48 ' telescope, and archival infrared and hard X-ray observations are used to construct and model the spectral energy distribution (SED) of the source with a synchrotron self-Compton model. The well-measured gamma-ray peak of the SED with VERITAS and Fermi-LAT provides constraining upper limits on the source redshift. Possible contribution of secondary gamma-rays from ultra-high-energy cosmic-ray-initiated electromagnetic cascades to the gamma-ray emission is explored, finding that only a segment of the VHE spectrum can be accommodated with this process. A variability search is performed across X-ray and gamma-ray bands. No statistically significant flux or spectral variability is detected.
Abeysekara, A. U. ; Archer, A. ; Benbow, Wystan ; Bird, Ralph ; Brill, A. ; Brose, Robert ; Buckley, J. H. ; Christiansen, Jessie L. ; Chromey, A. J. ; Daniel, M. K. ; Falcone, A. ; Feng, Qi ; Finley, John P. ; Fortson, L. ; Furniss, Amy ; Gillanders, Gerard H. ; Gueta, O. ; Hanna, David ; Hervet, O. ; Holder, J. ; Hughes, G. ; Humensky, T. B. ; Johnson, Caitlin A. ; Kaaret, Philip ; Kar, P. ; Kelley-Hoskins, N. ; Kertzman, M. ; Kieda, David ; Krause, Maria ; Krennrich, F. ; Lang, M. J. ; Moriarty, P. ; Mukherjee, Reshmi ; Ong, R. A. ; Otte, A. N. ; Park, N. ; Petrashyk, A. ; Pohl, Martin ; Pueschel, Elisa ; Quinn, J. ; Ragan, K. ; Reynolds, P. T. ; Richards, Gregory T. ; Roache, E. ; Rulten, C. ; Sadeh, I. ; Santander, Marcos ; Scott, S. S. ; Sembroski, G. H. ; Shahinyan, Karlen ; Tyler, J. ; Wakely, S. P. ; Weinstein, A. ; Wells, R. M. ; Wilcox, P. ; Wilhelm, Alina ; Williams, D. A. ; Williamson, T. J. ; Zitzer, B. ; Kaur, A.
On 2017 September 22, the IceCube Neutrino Observatory reported the detection of the high-energy neutrino event IC 170922A, of potential astrophysical origin. It was soon determined that the neutrino direction was consistent with the location of the gamma-ray blazar TXS 0506+056. (3FGL J0509.4+ 0541), which was in an elevated gamma-ray emission state as measured by the Fermi satellite. Very Energetic Radiation Imaging Telescope Array System (VERITAS) observations of the neutrino/blazar region started on 2017 September 23 in response to the neutrino alert and continued through 2018 February 6. While no significant very-high-energy (VHE; E > 100 GeV) emission was observed from the blazar by VERITAS in the two-week period immediately following the IceCube alert, TXS 0506+ 056 was detected by VERITAS with a significance of 5.8 standard deviations (sigma) in the full 35 hr data set. The average photon flux of the source during this period was (8.9 +/- 1.6). x. 10(-12) cm(-2) s(-1), or 1.6% of the Crab Nebula flux, above an energy threshold of 110 GeV, with a soft spectral index of 4.8. +/-. 1.3.
Archambault, S. ; Archer, A. ; Benbow, Wystan ; Bird, Ralph ; Bourbeau, E. ; Buchovecky, M. ; Buckley, J. H. ; Bugaev, V. ; Cerruti, M. ; Connolly, M. P. ; Cui, W. ; Dwarkadas, Vikram V. ; Errando, M. ; Falcone, A. ; Feng, Q. ; Finley, J. P. ; Fleischhack, H. ; Fortson, L. ; Furniss, A. ; Griffin, S. ; Huetten, M. ; Hanna, D. ; Holder, J. ; Johnson, C. A. ; Kaaret, P. ; Kar, P. ; Kelley-Hoskins, N. ; Kertzman, M. ; Kieda, D. ; Krause, M. ; Kumar, S. ; Lang, M. J. ; Maier, G. ; McArthur, S. ; McCann, A. ; Moriarty, P. ; Mukherjee, R. ; Nieto, D. ; Ong, R. A. ; Otte, A. N. ; Park, Nahee ; Pohl, Martin ; Popkow, A. ; Pueschel, Elisa ; Quinn, J. ; Ragan, K. ; Reynolds, P. T. ; Richards, G. T. ; Roache, E. ; Sadeh, I. ; Santander, M. ; Sembroski, G. H. ; Shahinyan, K. ; Slane, P. ; Staszak, D. ; Telezhinsky, Igor O. ; Trepanier, S. ; Tyler, J. ; Wakely, S. P. ; Weinstein, A. ; Weisgarber, T. ; Wilcox, P. ; Wilhelm, Alina ; Williams, D. A. ; Zitzer, B.
Radchuk, Viktoriia ; Reed, Thomas ; Teplitsky, Celine ; van de Pol, Martijn ; Charmantier, Anne ; Hassall, Christopher ; Adamik, Peter ; Adriaensen, Frank ; Ahola, Markus P. ; Arcese, Peter ; Miguel Aviles, Jesus ; Balbontin, Javier ; Berg, Karl S. ; Borras, Antoni ; Burthe, Sarah ; Clobert, Jean ; Dehnhard, Nina ; de Lope, Florentino ; Dhondt, Andre A. ; Dingemanse, Niels J. ; Doi, Hideyuki ; Eeva, Tapio ; Fickel, Jörns ; Filella, Iolanda ; Fossoy, Frode ; Goodenough, Anne E. ; Hall, Stephen J. G. ; Hansson, Bengt ; Harris, Michael ; Hasselquist, Dennis ; Hickler, Thomas ; Jasmin Radha, Jasmin ; Kharouba, Heather ; Gabriel Martinez, Juan ; Mihoub, Jean-Baptiste ; Mills, James A. ; Molina-Morales, Mercedes ; Moksnes, Arne ; Ozgul, Arpat ; Parejo, Deseada ; Pilard, Philippe ; Poisbleau, Maud ; Rousset, Francois ; Rödel, Mark-Oliver ; Scott, David ; Carlos Senar, Juan ; Stefanescu, Constanti ; Stokke, Bard G. ; Kusano, Tamotsu ; Tarka, Maja ; Tarwater, Corey E. ; Thonicke, Kirsten ; Thorley, Jack ; Wilting, Andreas ; Tryjanowski, Piotr ; Merila, Juha ; Sheldon, Ben C. ; Moller, Anders Pape ; Matthysen, Erik ; Janzen, Fredric ; Dobson, F. Stephen ; Visser, Marcel E. ; Beissinger, Steven R. ; Courtiol, Alexandre ; Kramer-Schadt, Stephanie
Biological responses to climate change have been widely documented across taxa and regions, but it remains unclear whether species are maintaining a good match between phenotype and environment, i.e. whether observed trait changes are adaptive. Here we reviewed 10,090 abstracts and extracted data from 71 studies reported in 58 relevant publications, to assess quantitatively whether phenotypic trait changes associated with climate change are adaptive in animals. A meta-analysis focussing on birds, the taxon best represented in our dataset, suggests that global warming has not systematically affected morphological traits, but has advanced phenological traits. We demonstrate that these advances are adaptive for some species, but imperfect as evidenced by the observed consistent selection for earlier timing. Application of a theoretical model indicates that the evolutionary load imposed by incomplete adaptive responses to ongoing climate change may already be threatening the persistence of species.
Kasmi, Sofien ; Zouhal, Hassane ; Hammami, Raouf ; Clark, Cain Craig Truman ; Hackney, Anthony C. ; Hammami, Amri ; Chtara, Moktar ; Chortane, Sabri Gaied ; Ben Salah, Fatma Zohra ; Granacher, Urs ; Ben Ounis, Omar
Background: The standard method to treat physically active patients with anterior cruciate ligament (ACL) rupture is ligament reconstruction surgery. The rehabilitation training program is very important to improve functional performance in recreational athletes following ACL reconstruction.
Objectives: The aims of this study were to compare the effects of three different training programs, eccentric training (ECC), plyometric training (PLYO), or combined eccentric and plyometric training (COMB), on dynamic balance (Y-BAL), the Lysholm Knee Scale (LKS), the return to sport index (RSI), and the leg symmetry index (LSI) for the single leg hop test for distance in elite female athletes after ACL surgery.
Materials and Methods: Fourteen weeks after rehabilitation from surgery, 40 elite female athletes (20.3 ± 3.2 years), who had undergone an ACL reconstruction, participated in a short-term (6 weeks; two times a week) training study. All participants received the same rehabilitation protocol prior to the training study. Athletes were randomly assigned to three experimental groups, ECC (n = 10), PLYO (n = 10), and COMB (n = 10), and to a control group (CON: n = 10). Testing was conducted before and after the 6-week training programs and included the Y-BAL, LKS, and RSI. LSI was assessed after the 6-week training programs only.
Results: Adherence rate was 100% across all groups and no training or test-related injuries were reported. No significant between-group baseline differences (pre-6-week training) were observed for any of the parameters. Significant group-by-time interactions were found for Y-BAL (p < 0.001, ES = 1.73), LKS (p < 0.001, ES = 0.76), and RSI (p < 0.001, ES = 1.39). Contrast analysis demonstrated that COMB yielded significantly greater improvements in Y-BAL, LKS, and RSI (all p < 0.001), in addition to significantly better performances in LSI (all p < 0.001), than CON, PLYO, and ECC, respectively.
Conclusion: In conclusion, combined (eccentric/plyometric) training seems to represent the most effective training method as it exerts positive effects on both stability and functional performance in the post-ACL-surgical rehabilitation period of elite female athletes.
Sariati, Dorsaf ; Zouhal, Hassane ; Hammami, Raouf ; Clark, Cain Craig Truman ; Nebigh, Ammar ; Chtara, Moktar ; Hackney, Anthony C. ; Souissi, Nizar ; Granacher, Urs ; Ben Ounis, Omar
Previous studies have not considered the potential influence of maturity status on the relationship between mental imagery and change of direction (CoD) speed in youth soccer. Accordingly, this cross-sectional study examined the association between mental imagery and CoD performance in young elite soccer players of different maturity status. Forty young male soccer players, aged 10-17 years, were assigned into two groups according to their predicted age at peak height velocity (PHV) (Pre-PHV; n = 20 and Post-PHV; n = 20). Participants were evaluated on soccer-specific tests of CoD with (CoDBall-15m) and without (CoD-15m) the ball. Participants completed the movement imagery questionnaire (MIQ) with the three- dimensional structure, internal visual imagery (IVI), external visual imagery (EVI), as well as kinesthetic imagery (KI). The Post-PHV players achieved significantly better results than Pre-PHV in EVI (ES = 1.58, large; p < 0.001), CoD-15m (ES = 2.09, very large; p < 0.001) and CoDBall-15m (ES = 1.60, large; p < 0.001). Correlations were significantly different between maturity groups, where, for the pre-PHV group, a negative very large correlation was observed between CoDBall-15m and KI (r = –0.73, p = 0.001). For the post-PHV group, large negative correlations were observed between CoD-15m and IVI (r = –0.55, p = 0.011), EVI (r = –062, p = 0.003), and KI (r = –0.52, p = 0.020). A large negative correlation of CoDBall-15m with EVI (r = –0.55, p = 0.012) and very large correlation with KI (r = –0.79, p = 0.001) were also observed. This study provides evidence of the theoretical and practical use for the CoD tasks stimulus with imagery. We recommend that sport psychology specialists, coaches, and athletes integrated imagery for CoD tasks in pre-pubertal soccer players to further improve CoD related performance.
Ecosystems' exposure to climate change - Modeling as support for nature conservation management
(2016)
Abeysekara, A. U. ; Archer, A. ; Aune, Taylor ; Benbow, Wystan ; Bird, Ralph ; Brose, Robert ; Buchovecky, M. ; Bugaev, V. ; Cui, Wei ; Daniel, M. K. ; Falcone, A. ; Feng, Qi ; Finley, John P. ; Fleischhack, H. ; Flinders, A. ; Fortson, L. ; Furniss, Amy ; Gotthelf, Eric V. ; Grube, J. ; Hanna, David ; Hervet, O. ; Holder, J. ; Huang, K. ; Hughes, G. ; Humensky, T. B. ; Huetten, M. ; Johnson, Caitlin A. ; Kaaret, Philip ; Kar, P. ; Kelley-Hoskins, N. ; Kertzman, M. ; Kieda, David ; Krause, Maria ; Kumar, S. ; Lang, M. J. ; Lin, T. T. Y. ; Maier, Gernot ; McArthur, S. ; Moriarty, P. ; Mukherjee, Reshmi ; Ong, R. A. ; Otte, Adam Nepomuk ; Pandel, Dirk ; Park, Nahee ; Petrashyk, A. ; Pohl, Martin ; Popkow, Alexis ; Pueschel, Elisa ; Quinn, J. ; Ragan, K. ; Reynolds, P. T. ; Richards, Gregory T. ; Roache, E. ; Rousselle, J. ; Rulten, C. ; Sadeh, I. ; Santander, M. ; Sembroski, G. H. ; Shahinyan, Karlen ; Tyler, J. ; Vassiliev, V. V. ; Wakely, S. P. ; Ward, J. E. ; Weinstein, A. ; Wells, R. M. ; Wilcox, P. ; Wilhelm, Alina ; Williams, David A. ; Zitzer, B.
We present results from deep observations toward the Cygnus region using 300 hr of very high energy (VHE)gamma-ray data taken with the VERITAS Cerenkov telescope array and over 7 yr of high-energy.-ray data taken with the Fermi satellite at an energy above 1 GeV. As the brightest region of diffuse gamma-ray emission in the northern sky, the Cygnus region provides a promising area to probe the origins of cosmic rays. We report the identification of a potential Fermi-LAT counterpart to VER J2031+415 (TeV J2032+4130) and resolve the extended VHE source VER J2019+368 into two source candidates (VER J2018+367* and VER J2020+368*) and characterize their energy spectra. The Fermi-LAT morphology of 3FGL J2021.0+4031e (the Gamma Cygni supernova remnant) was examined, and a region of enhanced emission coincident with VER J2019+407 was identified and jointly fit with the VERITAS data. By modeling 3FGL J2015.6+3709 as two sources, one located at the location of the pulsar wind nebula CTB 87 and one at the quasar QSO J2015+371, a continuous spectrum from 1 GeV to 10 TeV was extracted for VER J2016+371 (CTB 87). An additional 71 locations coincident with Fermi-LAT sources and other potential objects of interest were tested for VHE gamma-ray emission, with no emission detected and upper limits on the differential flux placed at an average of 2.3% of the Crab Nebula flux. We interpret these observations in a multiwavelength context and present the most detailed gamma-ray view of the region to date.
Drygala, Frank ; Korablev, Nikolay ; Ansorge, Hermann ; Fickel, Jörns ; Isomursu, Marja ; Elmeros, Morten ; Kowalczyk, Rafał ; Baltrunaite, Laima ; Balciauskas, Linas ; Saarma, Urmas ; Schulze, Christoph ; Borkenhagen, Peter ; Frantz, Alain C.
The extent of gene flow during the range expansion of non-native species influences the amount of genetic diversity retained in expanding populations. Here, we analyse the population genetic structure of the raccoon dog (Nyctereutes procyonoides) in north-eastern and central Europe. This invasive species is of management concern because it is highly susceptible to fox rabies and an important secondary host of the virus. We hypothesized that the large number of introduced animals and the species' dispersal capabilities led to high population connectivity and maintenance of genetic diversity throughout the invaded range. We genotyped 332 tissue samples from seven European countries using 16 microsatellite loci. Different algorithms identified three genetic clusters corresponding to Finland, Denmark and a large 'central' population that reached from introduction areas in western Russia to northern Germany. Cluster assignments provided evidence of long-distance dispersal. The results of an Approximate Bayesian Computation analysis supported a scenario of equal effective population sizes among different pre-defined populations in the large central cluster. Our results are in line with strong gene flow and secondary admixture between neighbouring demes leading to reduced genetic structuring, probably a result of its fairly rapid population expansion after introduction. The results presented here are remarkable in the sense that we identified a homogenous genetic cluster inhabiting an area stretching over more than 1500km. They are also relevant for disease management, as in the event of a significant rabies outbreak, there is a great risk of a rapid virus spread among raccoon dog populations.
Zouita, Sghaier ; Zouhal, Hassane ; Ferchichi, Habiba ; Paillard, Thierry ; Dziri, Catherine ; Hackney, Anthony C. ; Laher, Ismail ; Granacher, Urs ; Ben Moussa Zouita, Amira
Objective: We investigated the effects of combined balance and strength training on measures of balance and muscle strength in older women with a history of falls.
Methods: Twenty-seven older women aged 70.4 ± 4.1 years (age range: 65 to 75 years) were randomly allocated to either an intervention (IG, n = 12) or an active control (CG, n = 15) group. The IG completed 8 weeks combined balance and strength training program with three sessions per week including visual biofeedback using force plates. The CG received physical therapy and gait training at a rehabilitation center. Training volumes were similar between the groups. Pre and post training, tests were applied for the assessment of muscle strength (weight-bearing squat [WBS] by measuring the percentage of body mass borne by each leg at different knee flexions [0°, 30°, 60°, and 90°], sit-to-stand test [STS]), and balance. Balance tests used the modified clinical test of sensory interaction (mCTSIB) with eyes closed (EC) and opened (EO), on stable (firm) and unstable (foam) surfaces as well as spatial parameters of gait such as step width and length (cm) and walking speed (cm/s).
Results: Significant group × time interactions were found for different degrees of knee flexion during WBS (0.0001 < p < 0.013, 0.441 < d < 0.762). Post hoc tests revealed significant pre-to-post improvements for both legs and for all degrees of flexion (0.0001 < p < 0.002, 0.697 < d < 1.875) for IG compared to CG. Significant group × time interactions were found for firm EO, foam EO, firm EC, and foam EC (0.006 < p < 0.029; 0.302 < d < 0.518). Post hoc tests showed significant pre-to-post improvements for both legs and for all degrees of oscillations (0.0001 < p < 0.004, 0.753 < d < 2.097) for IG compared to CG. This study indicates that combined balance and strength training improved percentage distribution of body weight between legs at different conditions of knee flexion (0°, 30°, 60°, and 90°) and also decreased the sway oscillation on a firm surface with eyes closed, and on foam surface (with eyes opened or closed) in the IG.
Conclusion: The higher positive effects of training seen in standing balance tests, compared with dynamic tests, suggests that balance training exercises including lateral, forward, and backward exercises improved static balance to a greater extent in older women.
In Decolonizing Universalism: A Transnational Feminist Ethic zielt Serene Khader auf eine Neuausrichtung der feministischen Perspektive, welche es schafft, dekolonial und anti-imperialistisch zu sein, ohne gleichzeitig dem Universalismus komplett abzuschwören. Die Motivation hinter dieser Neuorientierung ist die Einsicht, dass der liberale moralische Universalismus oftmals kulturelle Vorherrschaft und Imperialismus verstärkt. In diesem Kommentar wollen wir (a) uns mit der Frage beschäftigen, was genau unter Geschlechtergerechtigkeit verstanden werden soll und welcher Maßstab zur Beantwortung der Frage nach Gerechtigkeit angebracht ist und (b) einige Ideen zum Unterschied zwischen idealer und nicht-idealer Theorie liefern.
Abeysekara, A. U. ; Benbow, Wystan ; Bird, Ralph ; Brantseg, T. ; Brose, Robert ; Buchovecky, M. ; Buckley, J. H. ; Bugaev, V. ; Connolly, M. P. ; Cui, Wei ; Daniel, M. K. ; Falcone, A. ; Feng, Qi ; Finley, John P. ; Fortson, L. ; Furniss, Amy ; Gillanders, Gerard H. ; Gunawardhana, Isuru ; Huetten, M. ; Hanna, David ; Hervet, O. ; Holder, J. ; Hughes, G. ; Humensky, T. B. ; Johnson, Caitlin A. ; Kaaret, Philip ; Kar, P. ; Kertzman, M. ; Krennrich, F. ; Lang, M. J. ; Lin, T. T. Y. ; McArthur, S. ; Moriarty, P. ; Mukherjee, Reshmi ; Ong, R. A. ; Otte, Adam Nepomuk ; Park, N. ; Petrashyk, A. ; Pohl, Martin ; Pueschel, Elisa ; Quinn, J. ; Ragan, K. ; Reynolds, P. T. ; Richards, Gregory T. ; Roache, E. ; Rulten, C. ; Sadeh, I. ; Santander, M. ; Sembroski, G. H. ; Shahinyan, Karlen ; Wakely, S. P. ; Weinstein, A. ; Wells, R. M. ; Wilcox, P. ; Williams, D. A. ; Zitzer, B. ; Jorstad, Svetlana G. ; Marscher, Alan P. ; Lister, Matthew L. ; Kovalev, Yuri Y. ; Pushkarev, A. B. ; Savolainen, Tuomas ; Agudo, I. ; Molina, S. N. ; Gomez, J. L. ; Larionov, Valeri M. ; Borman, G. A. ; Mokrushina, A. A. ; Tornikoski, Merja ; Lahteenmaki, A. ; Chamani, W. ; Enestam, S. ; Kiehlmann, S. ; Hovatta, Talvikki ; Smith, P. S. ; Pontrelli, P.
Combined with measurements made by very-long-baseline interferometry, the observations of fast TeV gamma-ray flares probe the structure and emission mechanism of blazar jets. However, only a handful of such flares have been detected to date, and only within the last few years have these flares been observed from lower-frequency-peaked BL. Lac objects and flat-spectrum radio quasars. We report on a fast TeV gamma-ray flare from the blazar BL. Lacertae observed by the Very Energetic Radiation Imaging Telescope Array System (VERITAS). with a rise time of similar to 2.3 hr and a decay time of similar to 36 min. The peak flux above 200 GeV is (4.2 +/- 0.6) x 10(-6) photon m(-2) s(-1) measured with a 4-minute-binned light curve, corresponding to similar to 180% of the flux that is observed from the Crab Nebula above the same energy threshold. Variability contemporaneous with the TeV gamma-ray flare was observed in GeV gamma-ray, X-ray, and optical flux, as well as in optical and radio polarization. Additionally, a possible moving emission feature with superluminal apparent velocity was identified in Very Long Baseline Array observations at 43 GHz, potentially passing the radio core of the jet around the time of the gamma-ray flare. We discuss the constraints on the size, Lorentz factor, and location of the emitting region of the flare, and the interpretations with several theoretical models that invoke relativistic plasma passing stationary shocks.
Multiwavelength observations of the AGN 1ES 0414+009 with veritas, FERMI-LAT, SWIFT-XRT, AND MDM
(2012)
Aliu, E. ; Archambault, S. ; Arlen, T. ; Aune, T. ; Beilicke, M. ; Benbow, W. ; Boettcher, Markus ; Bouvier, A. ; Bugaev, V. ; Cannon, A. ; Cesarini, A. ; Ciupik, L. ; Collins-Hughes, E. ; Connolly, M. P. ; Cui, W. ; Dickherber, R. ; Dumm, J. ; Errando, M. ; Falcone, A. ; Federici, Stefania ; Feng, Q. ; Finley, J. P. ; Finnegan, G. ; Fortson, L. ; Furniss, A. ; Galante, N. ; Gall, D. ; Godambe, S. ; Griffin, S. ; Grube, J. ; Gyuk, G. ; Hanna, D. ; Holder, J. ; Huan, H. ; Hughes, G. ; Hui, C. M. ; Imran, A. ; Jameil, O. ; Kaaret, P. ; Karlsson, N. ; Kertzman, M. ; Kerr, J. ; Khassen, Y. ; Kieda, D. ; Krawczynski, H. ; Krennrich, F. ; Lang, M. J. ; Lee, K. ; Madhavan, A. S. ; Majumdar, P. ; McArthur, S. ; McCann, A. ; Moriarty, P. ; Mukherjee, R. ; Nelson, T. ; de Bhroithe, A. O'Faolain ; Ong, R. A. ; Orr, M. ; Otte, A. N. ; Park, N. ; Perkins, J. S. ; Pichel, A. ; Pohl, Martin ; Quinn, J. ; Ragan, K. ; Reynolds, P. T. ; Roache, E. ; Ruppel, J. ; Saxon, D. B. ; Schroedter, M. ; Sembroski, G. H. ; Sentuerk, G. D. ; Smith, A. W. ; Staszak, D. ; Stroh, M. ; Telezhinsky, Igor O. ; Tesic, G. ; Theiling, M. ; Thibadeau, S. ; Tsurusaki, K. ; Varlotta, A. ; Vassiliev, V. V. ; Vivier, M. ; Wakely, S. P. ; Ward, J. E. ; Weinstein, A. ; Welsing, R. ; Williams, D. A. ; Zitzer, B.
We present observations of the BL Lac object 1ES 0414+009 in the >200 GeV gamma-ray band by the VERITAS array of Cherenkov telescopes. 1ES 0414+009 was observed by VERITAS between 2008 January and 2011 February, resulting in 56.2 hr of good quality pointed observations. These observations resulted in a detection of 822 events from the source corresponding to a statistical significance of 6.4 standard deviations (6.4 sigma) above the background. The source flux, showing no evidence for variability, is measured as (5.2 +/- 1.1(stat) +/- 2.6(sys)) x 10(-12) photons cm(-2) s(-1) above 200 GeV, equivalent to approximately 2% of the Crab Nebula flux above this energy. The differential photon spectrum from 230 GeV to 850 GeV is well fit by a power law with a photon index of Gamma = 3.4 +/- 0.5(stat) +/- 0.3(sys) and a flux normalization of (1.6 +/- 0.3(stat) +/- 0.8(sys)) x 10(-11) photons cm(-2) s(-1) at 300 GeV. We also present multiwavelength results taken in the optical (MDM), x-ray (Swift-XRT), and GeV (Fermi-LAT) bands and use these results to construct a broadband spectral energy distribution (SED). Modeling of this SED indicates that homogenous one-zone leptonic scenarios are not adequate to describe emission from the system, with a lepto-hadronic model providing a better fit to the data.
Dämpfling, Helge L. C. ; Mielke, Christian ; Koellner, Nicole ; Lorenz, Melanie ; Rogass, Christian ; Altenberger, Uwe ; Harlov, Daniel E. ; Knoper, Michael
In this study we present a novel method for the automatic detection of minerals and elements using hyperspectral transmittance imaging microscopy measurements of complete thin sections (HyperTIM).
This is accomplished by using a hyperspectral camera system that operates in the visible and near-infrared (VNIR) range with a specifically designed sample holder, scanning setup, and a microscope lens.
We utilize this method on a monazite ore thin section from Steenkampskraal (South Africa), which we analyzed for the rare earth element (REE)-bearing mineral monazite ((Ce,Nd,La)PO4), with high concentrations of Nd. The transmittance analyses with the hyperspectral VNIR camera can be used to identify REE minerals and Nd in thin sections.
We propose a three-point band depth index, the Nd feature depth index (NdFD), and its related product the Nd band depth index (NdBDI), which enables automatic mineral detection and classification for the Nd-bearing monazites in thin sections. In combination with the average concentration of the relative Nd content, it permits a destruction-free, total concentration calculation for Nd across the entire thin section.
The results of streamflow trend studies are often characterized by mostly insignificant trends and inexplicable spatial patterns. In our study region, Western Austria, this applies especially for trends of annually averaged runoff. However, analysing the altitudinal aspect, we found that there is a trend gradient from higher-altitude to lower-altitude stations, i.e. a pattern of mostly positive annual trends at higher stations and negative ones at lower stations. At midaltitudes, the trends are mostly insignificant. Here we hypothesize that the streamflow trends are caused by the following two main processes: on the one hand, melting glaciers produce excess runoff at higher-altitude watersheds. On the other hand, rising temperatures potentially alter hydrological conditions in terms of less snowfall, higher infiltration, enhanced evapotranspiration, etc., which in turn results in decreasing streamflow trends at lower-altitude watersheds. However, these patterns are masked at mid-altitudes because the resulting positive and negative trends balance each other. To support these hypotheses, we attempted to attribute the detected trends to specific causes. For this purpose, we analysed trends of filtered daily streamflow data, as the causes for these changes might be restricted to a smaller temporal scale than the annual one. This allowed for the explicit determination of the exact days of year (DOYs) when certain streamflow trends emerge, which were then linked with the corresponding DOYs of the trends and characteristic dates of other observed variables, e.g. the average DOY when temperature crosses the freezing point in spring. Based on these analyses, an empirical statistical model was derived that was able to simulate daily streamflow trends sufficiently well. Analyses of subdaily streamflow changes provided additional insights. Finally, the present study supports many modelling approaches in the literature which found out that the main drivers of alpine streamflow changes are increased glacial melt, earlier snowmelt and lower snow accumulation in wintertime.
Abeysekara, A. U. ; Archer, A. ; Benbow, Wystan ; Bird, Ralph ; Brose, Robert ; Buchovecky, M. ; Bugaev, V. ; Connolly, M. P. ; Cui, Wei ; Errando, Manel ; Falcone, A. ; Feng, Qi ; Finley, John P. ; Flinders, A. ; Fortson, L. ; Furniss, Amy ; Gillanders, Gerard H. ; Huetten, M. ; Hanna, David ; Hervet, O. ; Holder, J. ; Hughes, G. ; Humensky, T. B. ; Johnson, Caitlin A. ; Kaaret, Philip ; Kar, P. ; Kelley-Hoskins, N. ; Kertzman, M. ; Kieda, David ; Krause, Maria ; Krennrich, F. ; Lang, M. J. ; Lin, T. T. Y. ; Maier, Gernot ; McArthur, S. ; Moriarty, P. ; Mukherjee, Reshmi ; Ong, R. A. ; Park, N. ; Perkins, Jeremy S. ; Petrashyk, A. ; Pohl, Martin ; Popkow, Alexis ; Pueschel, Elisa ; Quinn, J. ; Ragan, K. ; Reynolds, P. T. ; Richards, Gregory T. ; Roache, E. ; Rulten, C. ; Sadeh, I. ; Santander, M. ; Sembroski, G. H. ; Shahinyan, Karlen ; Tyler, J. ; Wakely, S. P. ; Weiner, O. M. ; Weinstein, A. ; Wells, R. M. ; Wilcox, P. ; Wilhelm, Alina ; Williams, David A. ; Zitzer, B. ; Vurm, Indrek ; Beloborodov, Andrei
On 2015 March 23, the Very Energetic Radiation Imaging Telescope Array System (VERITAS) responded to a Swift-Burst Alert Telescope (BAT) detection of a gamma-ray burst, with observations beginning 270 s after the onset of BAT emission, and only 135 s after the main BAT emission peak. No statistically significant signal is detected above 140 GeV. The VERITAS upper limit on the fluence in a 40-minute integration corresponds to about 1% of the prompt fluence. Our limit is particularly significant because the very-high-energy (VHE) observation started only similar to 2 minutes after the prompt emission peaked, and Fermi-Large Area Telescope observations of numerous other bursts have revealed that the high-energy emission is typically delayed relative to the prompt radiation and lasts significantly longer. Also, the proximity of GRB 150323A (z = 0.593) limits the attenuation by the extragalactic background light to similar to 50% at 100-200 GeV. We conclude that GRB 150323A had an intrinsically very weak high-energy afterglow, or that the GeV spectrum had a turnover below similar to 100 GeV. If the GRB exploded into the stellar wind of a massive progenitor, the VHE non-detection constrains the wind density parameter to be A greater than or similar to 3 x 10(11) g . cm(-1), consistent with a standard Wolf-Rayet progenitor. Alternatively, the VHE emission from the blast wave would be weak in a very tenuous medium such as the interstellar medium, which therefore cannot be ruled out as the environment of GRB 150323A.
Aliu, E. ; Archambault, S. ; Aune, T. ; Behera, B. ; Beilicke, M. ; Benbow, W. ; Berger, K. ; Bird, R. ; Buckley, J. H. ; Bugaev, V. ; Cardenzana, J. V. ; Cerruti, M. ; Chen, Xuhui ; Ciupik, L. ; Collins-Hughes, E. ; Connolly, M. P. ; Cui, W. ; Dumm, J. ; Dwarkadas, Vikram V. ; Errando, M. ; Falcone, A. ; Federici, Simone ; Feng, Q. ; Finley, J. P. ; Fleischhack, H. ; Fortin, P. ; Fortson, L. ; Furniss, A. ; Galante, N. ; Gall, D. ; Gillanders, G. H. ; Griffin, S. ; Griffiths, S. T. ; Grube, J. ; Gyuk, G. ; Hanna, D. ; Holder, J. ; Hughes, G. ; Humensky, T. B. ; Kaaret, P. ; Kertzman, M. ; Khassen, Y. ; Kieda, D. ; Krennrich, F. ; Kumar, S. ; Lang, M. J. ; Madhavan, A. S. ; Maier, G. ; McCann, A. J. ; Meagher, K. ; Millis, J. ; Moriarty, P. ; Mukherjee, R. ; Nieto, D. ; Ong, R. A. ; Otte, A. N. ; Pandel, D. ; Park, N. ; Pohl, Martin ; Popkow, A. ; Prokoph, H. ; Quinn, J. ; Ragan, K. ; Rajotte, J. ; Ratliff, G. ; Reyes, L. C. ; Reynolds, P. T. ; Richards, G. T. ; Roache, E. ; Rousselle, J. ; Sembroski, G. H. ; Shahinyan, K. ; Sheidaei, F. ; Smith, A. W. ; Staszak, D. ; Telezhinsky, Igor O. ; Tsurusaki, K. ; Tucci, J. V. ; Tyler, J. ; Varlotta, A. ; Vassiliev, V. V. ; Vincent, S. ; Wakely, S. P. ; Ward, J. E. ; Weinstein, A. ; Welsing, R. ; Wilhelm, Alina
We report on deep observations of the extended TeV gamma-ray source MGRO J1908+06 made with the VERITAS very high energy gamma-ray observatory. Previously, the TeV emission has been attributed to the pulsar wind nebula (PWN) of the Fermi-LAT pulsar PSR J1907+0602. We detect MGRO J1908+06 at a significance level of 14 standard deviations (14 sigma) and measure a photon index of 2.20 +/- 0.10(stat) +/- 0.20(sys). The TeV emission is extended, covering the region near PSR J1907+0602 and also extending toward SNR G40.5-0.5. When fitted with a two-dimensional Gaussian, the intrinsic extension has a standard deviation of sigma(src) = 0 degrees.44 +/- 0 degrees.02. In contrast to other TeV PWNe of similar age in which the TeV spectrum softens with distance from the pulsar, the TeV spectrum measured near the pulsar location is consistent with that measured at a position near the rim of G40.5-0.5, 0 degrees.33 away.
Sarcopenia
(2020)
Wiedmer, Petra ; Jung, Tobias ; Castro, Jose Pedro ; Pomatto, Laura C. D. ; Sun, Patrick Y. ; Davies, Kelvin J. A. ; Grune, Tilman
Sarcopenia represents a muscle-wasting syndrome characterized by progressive and generalized degenerative loss of skeletal muscle mass, quality, and strength occurring during normal aging. Sarcopenia patients are mainly suffering from the loss in muscle strength and are faced with mobility disorders reducing their quality of life and are, therefore, at higher risk for morbidity (falls, bone fracture, metabolic diseases) and mortality. <br /> Several molecular mechanisms have been described as causes for sarcopenia that refer to very different levels of muscle physiology. These mechanisms cover e. g. function of hormones (e. g. IGF-1 and Insulin), muscle fiber composition and neuromuscular drive, myo-satellite cell potential to differentiate and proliferate, inflammatory pathways as well as intracellular mechanisms in the processes of proteostasis and mitochondrial function. <br /> In this review, we describe sarcopenia as a muscle-wasting syndrome distinct from other atrophic diseases and summarize the current view on molecular causes of sarcopenia development as well as open questions provoking further research efforts for establishing efficient lifestyle and therapeutic interventions.
Channel transmission losses in drylands take place normally in extensive alluvial channels or streambeds underlain by fractured rocks. They can play an important role in streamflow rates, groundwater recharge, freshwater supply and channel-associated ecosystems. We aim to develop a process-oriented, semi-distributed channel transmission losses model, using process formulations which are suitable for data-scarce dryland environments and applicable to both hydraulically disconnected losing streams and hydraulically connected losing(/gaining) streams. This approach should be able to cover a large variation in climate and hydro-geologic controls, which are typically found in dryland regions of the Earth. Our model was first evaluated for a losing/gaining, hydraulically connected 30 km reach of the Middle Jaguaribe River (MJR), Ceara, Brazil, which drains a catchment area of 20 000 km(2). Secondly, we applied it to a small losing, hydraulically disconnected 1.5 km channel reach in the Walnut Gulch Experimental Watershed (WGEW), Arizona, USA. The model was able to predict reliably the streamflow volume and peak for both case studies without using any parameter calibration procedure. We have shown that the evaluation of the hypotheses on the dominant hydrological processes was fundamental for reducing structural model uncertainties and improving the streamflow prediction. For instance, in the case of the large river reach (MJR), it was shown that both lateral stream-aquifer water fluxes and groundwater flow in the underlying alluvium parallel to the river course are necessary to predict streamflow volume and channel transmission losses, the former process being more relevant than the latter. Regarding model uncertainty, it was shown that the approaches, which were applied for the unsaturated zone processes (highly nonlinear with elaborate numerical solutions), are much more sensitive to parameter variability than those approaches which were used for the saturated zone (mathematically simple water budgeting in aquifer columns, including backwater effects). In case of the MJR-application, we have seen that structural uncertainties due to the limited knowledge of the subsurface saturated system interactions (i.e. groundwater coupling with channel water; possible groundwater flow parallel to the river) were more relevant than those related to the subsurface parameter variability. In case of the WEGW application we have seen that the non-linearity involved in the unsaturated flow processes in disconnected dryland river systems (controlled by the unsaturated zone) generally contain far more model uncertainties than do connected systems controlled by the saturated flow. Therefore, the degree of aridity of a dryland river may be an indicator of potential model uncertainty and subsequent attainable predictability of the system.
Drygala, Frank ; Korablev, Nikolay ; Ansorge, Hermann ; Fickel, Jörns ; Isomursu, Marja ; Elmeros, Morten ; Kowalczyk, Rafal ; Baltrunaite, Laima ; Balciauskas, Linas ; Saarma, Urmas ; Schulze, Christoph ; Borkenhagen, Peter ; Frantz, Alain C.
The extent of gene flow during the range expansion of non-native species influences the amount of genetic diversity retained in expanding populations. Here, we analyse the population genetic structure of the raccoon dog (Nyctereutes procyonoides) in north-eastern and central Europe. This invasive species is of management concern because it is highly susceptible to fox rabies and an important secondary host of the virus. We hypothesized that the large number of introduced animals and the species’ dispersal capabilities led to high population connectivity and maintenance of genetic diversity throughout the invaded range. We genotyped 332 tissue samples from seven European countries using 16 microsatellite loci. Different algorithms identified three genetic clusters corresponding to Finland, Denmark and a large ‘central’ population that reached from introduction areas in western Russia to northern Germany. Cluster assignments provided evidence of long-distance dispersal. The results of an Approximate Bayesian Computation analysis supported a scenario of equal effective population sizes among different pre-defined populations in the large central cluster. Our results are in line with strong gene flow and secondary admixture between neighbouring demes leading to reduced genetic structuring, probably a result of its fairly rapid population expansion after introduction. The results presented here are remarkable in the sense that we identified a homogenous genetic cluster inhabiting an area stretching over more than 1500km. They are also relevant for disease management, as in the event of a significant rabies outbreak, there is a great risk of a rapid virus spread among raccoon dog populations.
Arazi, Hamid ; Asadi, Abbas ; Khalkhali, Farhood ; Boullosa, Daniel ; Hackney, Anthony C. ; Granacher, Urs ; Zouhal, Hassane
This study aimed to investigate the relationship between the acute to chronic workload ratio (ACWR), based upon participant session rating of perceived exertion (sRPE), using two models [(1) rolling averages (ACWRRA); and (2) exponentially weighted moving averages (ACWREWMA)] and the injury rate in young male team soccer players aged 17.1 ± 0.7 years during a competitive mesocycle. Twenty-two players were enrolled in this study and performed four training sessions per week with 2 days of recovery and 1 match day per week. During each training session and each weekly match, training time and sRPE were recorded. In addition, training impulse (TRIMP), monotony, and strain were subsequently calculated. The rate of injury was recorded for each soccer player over a period of 4 weeks (i.e., 28 days) using a daily questionnaire. The results showed that over the course of the study, the number of non-contact injuries was significantly higher than that for contact injuries (2.5 vs. 0.5, p = 0.01). There were also significant positive correlations between sRPE and training time (r = 0.411, p = 0.039), ACWRRA (r = 0.47, p = 0.049), and ACWREWMA (r = 0.51, p = 0.038). In addition, small-to-medium correlations were detected between ACWR and non-contact injury occurrence (ACWRRA, r = 0.31, p = 0.05; ACWREWMA, r = 0.53, p = 0.03). Explained variance (r²) for non-contact injury was significantly greater using the ACWREWMA model (ranging between 21 and 52%) compared with ACWRRA (ranging between 17 and 39%). In conclusion, the results of this study showed that the ACWREWMA model is more sensitive than ACWRRA to identify non-contact injury occurrence in male team soccer players during a short period in the competitive season.