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Previous thermomechanical modeling studies indicated that variations in the temperature and strength of the crystalline crust might be responsible for the juxtaposition of domains with thin-skinned and thick-skinned crustal deformation along strike the foreland of the central Andes. However, there is no evidence supporting this hypothesis from data-integrative models. We aim to derive the density structure of the lithosphere by means of integrated 3-D density modeling, in order to provide a new basis for discussions of compositional variations within the crust and for future thermal and rheological modeling studies. Therefore, we utilize available geological and geophysical data to obtain a structural and density model of the uppermost 200km of the Earth. The derived model is consistent with the observed Bouguer gravity field. Our results indicate that the crystalline crust in northern Argentina can be represented by a lighter upper crust (2,800kg/m(3)) and a denser lower crust (3,100kg/m(3)). We find new evidence for high bulk crustal densities >3,000kg/m(3) in the northern Pampia terrane. These could originate from subducted Puncoviscana wackes or pelites that ponded to the base of the crystalline crust in the late Proterozoic or indicate increasing bulk content of mafic material. The precise composition of the northern foreland crust, whether mafic or felsic, has significant implications for further thermomechanical models and the rheological behavior of the lithosphere. A detailed sensitivity analysis of the input parameters indicates that the model results are robust with respect to the given uncertainties of the input data.
Vaz da Cruz, Vinicius ; Ertan, Emelie ; Couto, Rafael C. ; Eckert, Sebastian ; Fondell, Mattis ; Dantz, Marcus ; Kennedy, Brian ; Schmitt, Thorsten ; Pietzsch, Annette ; Guimarães, Freddy F. ; Ågren, Hans ; Gel'mukhanov, Faris ; Odelius, Michael ; Föhlisch, Alexander ; Kimberg, Victor
In this combined theoretical and experimental study we report a full analysis of the resonant inelastic X-ray scattering (RIXS) spectra of H2O, D2O and HDO. We demonstrate that electronically-elastic RIXS has an inherent capability to map the potential energy surface and to perform vibrational analysis of the electronic ground state in multimode systems. We show that the control and selection of vibrational excitation can be performed by tuning the X-ray frequency across core-excited molecular bands and that this is clearly reflected in the RIXS spectra. Using high level ab initio electronic structure and quantum nuclear wave packet calculations together with high resolution RIXS measurements, we discuss in detail the mode coupling, mode localization and anharmonicity in the studied systems.
Wisotzki, Lutz ; Bacon, R. ; Brinchmann, J. ; Cantalupo, S. ; Richter, Philipp ; Schaye, J. ; Schmidt, Kasper Borello ; Urrutia, Tanya ; Weilbacher, Peter Michael ; Akhlaghi, M. ; Bouche, N. ; Contini, T. ; Guiderdoni, B. ; Herenz, E. C. ; Inami, H. ; Kerutt, Josephine Victoria ; Leclercq, F. ; Marino, R. A. ; Maseda, M. ; Monreal-Ibero, A. ; Nanayakkara, T. ; Richard, J. ; Saust, R. ; Steinmetz, Matthias ; Wendt, Martin
Galaxies are surrounded by large reservoirs of gas, mostly hydrogen, that are fed by inflows from the intergalactic medium and by outflows from galactic winds. Absorption-line measurements along the lines of sight to bright and rare background quasars indicate that this circumgalactic medium extends far beyond the starlight seen in galaxies, but very little is known about its spatial distribution. The Lyman-alpha transition of atomic hydrogen at a wavelength of 121.6 nanometres is an important tracer of warm (about 104 kelvin) gas in and around galaxies, especially at cosmological redshifts greater than about 1.6 at which the spectral line becomes observable from the ground. Tracing cosmic hydrogen through its Lyman-a emission has been a long-standing goal of observational astrophysics(1-3), but the extremely low surface brightness of the spatially extended emission is a formidable obstacle. A new window into circumgalactic environments was recently opened by the discovery of ubiquitous extended Lyman-alpha emission from hydrogen around high-redshift galaxies(4,5). Such measurements were previously limited to especially favourable systems(6-8) or to the use of massive statistical averaging(9,10) because of the faintness of this emission. Here we report observations of low-surface-brightness Lyman-alpha emission surrounding faint galaxies at redshifts between 3 and 6. We find that the projected sky coverage approaches 100 per cent. The corresponding rate of incidence (the mean number of Lyman-alpha emitters penetrated by any arbitrary line of sight) is well above unity and similar to the incidence rate of high-column-density absorbers frequently detected in the spectra of distant quasars(11-14). This similarity suggests that most circumgalactic atomic hydrogen at these redshifts has now been detected in emission.
Marggraf, Lara Christin ; Lindecke, Oliver ; Voigt, Christian C. ; Pētersons, Gunārs ; Voigt-Heucke, Silke Luise
In late summer, migratory bats of the temperate zone face the challenge of accomplishing two energy-demanding tasks almost at the same time: migration and mating. Both require information and involve search efforts, such as localizing prey or finding potential mates. In non-migrating bat species, playback studies showed that listening to vocalizations of other bats, both con-and heterospecifics, may help a recipient bat to find foraging patches and mating sites. However, we are still unaware of the degree to which migrating bats depend on con-or heterospecific vocalizations for identifying potential feeding or mating opportunities during nightly transit flights. Here, we investigated the vocal responses of Nathusius’ pipistrelle bats, Pipistrellus nathusii, to simulated feeding and courtship aggregations at a coastal migration corridor. We presented migrating bats either feeding buzzes or courtship calls of their own or a heterospecific migratory species, the common noctule, Nyctalus noctula. We expected that during migratory transit flights, simulated feeding opportunities would be particularly attractive to bats, as well as simulated mating opportunities which may indicate suitable roosts for a stopover. However, we found that when compared to the natural silence of both pre-and post-playback phases, bats called indifferently during the playback of conspecific feeding sounds, whereas P. nathusii echolocation call activity increased during simulated feeding of N. noctula. In contrast, the call activity of P. nathusii decreased during the playback of conspecific courtship calls, while no response could be detected when heterospecific call types were broadcasted. Our results suggest that while on migratory transits, P. nathusii circumnavigate conspecific mating aggregations, possibly to save time or to reduce the risks associated with social interactions where aggression due to territoriality might be expected. This avoidance behavior could be a result of optimization strategies by P. nathusii when performing long-distance migratory flights, and it could also explain the lack of a response to simulated conspecific feeding. However, the observed increase of activity in response to simulated feeding of N. noctula, suggests that P. nathusii individuals may be eavesdropping on other aerial hawking insectivorous species during migration, especially if these occupy a slightly different foraging niche.
Hollmann, C. ; Reuter, D. ; Werner, S. ; Avota, Elita ; Mueller, N. ; Japtok, Lukasz ; Kleuser, Burkhard ; Becker, Katrin Anne ; Gulbins, Erich ; Schneider-Schaulies, Jürgen ; Beyersdorf, Niklas
Hoehn, Richard S. ; Jernigan, Peter L. ; Japtok, Lukasz ; Chang, Alex L. ; Midura, Emily F. ; Caldwell, Charles C. ; Kleuser, Burkhard ; Lentsch, Alex B. ; Edwards, Michael J. ; Gulbins, Erich ; Pritts, Timothy A.
Objective: We aimed to identify the role of the enzyme acid sphingomyelinase in the aging of stored units of packed red blood cells (pRBCs) and subsequent lung inflammation after transfusion.
Summary Background Data: Large volume pRBC transfusions are associated with multiple adverse clinical sequelae, including lung inflammation. Microparticles are formed in stored pRBCs over time and have been shown to contribute to lung inflammation after transfusion.
Methods: Human and murine pRBCs were stored with or without amitriptyline, a functional inhibitor of acid sphingomyelinase, or obtained from acid sphingomyelinase-deficient mice, and lung inflammation was studied in mice receiving transfusions of pRBCs and microparticles isolated from these units.
Results: Acid sphingomyelinase activity in pRBCs was associated with the formation of ceramide and the release of microparticles. Treatment of pRBCs with amitriptyline inhibited acid sphingomyelinase activity, ceramide accumulation, and microparticle production during pRBC storage. Transfusion of aged pRBCs or microparticles isolated from aged blood into mice caused lung inflammation. This was attenuated after transfusion of pRBCs treated with amitriptyline or from acid sphingomyelinase-deficient mice.
Conclusions: Acid sphingomyelinase inhibition in stored pRBCs offers a novel mechanism for improving the quality of stored blood.
Halibasic, Emina ; Fuerst, Elisabeth ; Heiden, Denis ; Japtok, Lukasz ; Diesner, Susanne C. ; Hillebrand, P. ; Trauner, Michael ; Kleuser, Burkhard ; Kazemi-Shirazi, Lili ; Untersmayr, Eva
Obtaining a complete census of massive, evolved stars in a galaxy would be a key ingredient for testing stellar evolution models. However, as the evolution of stars is also strongly dependent on their metallicity, it is inevitable to have this kind of data for a variety of galaxies with different metallicities. Between 2009 and 2011, we conducted the Magellanic Clouds Massive Stars and Feedback Survey (MSCF); a spatially complete, multi-epoch, broad- and narrow-band optical imaging survey of the Large and Small Magellanic Clouds. With the inclusion of shallow images, we are able to give a complete photometric catalog of stars between B ≈ 18 and B ≈ 19 mag.
These observations were augmented with additional photometric data of similar spatial res-
olution from UV to IR (e.g. from GALEX, 2MASS and Spitzer) in order to sample a large portion of the spectral energy distribution of the brightest stars (B < 16 mag) in the Magel- lanic Clouds. Using these data, were are able to train a machine learning algorithm that gives us a good estimate of the spectral type of tens of thousands of stars.
This method can be applied to the search for Wolf-Rayet-Stars to obtain a sample of candi- dates for follow-up observations. As this approach can, in principle, be adopted for any resolved galaxy as long as sufficient photometric data is available, it can form an effective alternative method to the classical strategies (e.g. He II filter imaging).
Russell, C. M. P. ; Corcoran, M. F. ; Cuadra, J. ; Owocki, S. P. ; Wang, Q. D. ; Hamaguchi, K. ; Sugawara, Y. ; Pollock, A. M. T. ; Kallman, T. R.
Colliding Wolf-Rayet (WR) winds produce thermal X-ray emission widely observed by X-ray telescopes. In wide WR+O binaries, such as WR 140, the X-ray flux is tied to the orbital phase, and is a direct probe of the winds’ properties. In the Galactic center, ~30 WRs orbit the super massive black hole (SMBH) within ~10”, leading to a smorgasbord of wind-wind collisions. To model the X-ray emission of WR 140 and the Galactic center, we perform 3D hydrodynamic simulations to trace the complex gaseous flows, and then carry out 3D radiative transfer calculations to compute the variable X-ray spectra. The model WR 140 RXTE light curve matches the data well for all phases except the X-ray minimum associated with periastron, while the model spectra agree with the RXTE hardness ratio and the shape of the Suzaku observations throughout the orbit. The Galactic center model of the Chandra flux and spectral shape match well in the region r ≤ 3”, but the model flux falls off too rapidly beyond this radius.
Ring Nebulae
(2015)
Preliminary results are presented from spectroscopic data in the optical range of the Galactic ring nebulae NGC 6888, G2:4+1:4, RCW 58 and Sh2-308. Deep observations with long exposure times were carried out at the 6.5m Clay Telescope and at the 10.4m Gran Telescopio Canarias. In NGC 6888, recombination lines of C ii, O ii and N ii are detected with signal-to-noise ratios higher than 8. The chemical content of NGC 6888 is discussed within the chemical enrichment predicted by evolution models of massive stars. For all nebulae, a forthcoming work will content in-depth details about observations, analysis and final results (Esteban et al. 2015, in prep.).
We present results of investigation of spectral variability of one of the most interesting massive stars, Romano's star (M33/V532 or GR290), located in the M33 galaxy. Brightness of the star changes together with its spectral class, which varies from WN11 to WN8. Using CMFGEN code we estimated parameters of stellar atmosphere and found that during last ten years bolometric luminosity of the star changed synchronously with stellar magnitude. Our calculations argue in favor of the hypothesis of a post-LBV status of GR290.
Meynet, G. ; Georgy, C. ; Maeder, A. ; Ekström, S. ; Groh, J. H. ; Barblan, F. ; Song, H. F. ; Eggenberger, P.
Key physical ingredients governing the evolution of massive stars are mass losses, convection and mixing in radiative zones. These effects are important both in the frame of single and close binary evolution. The present paper addresses two points: 1) the differences between two families of rotating models, i.e. the family of models computed with and without an efficient transport of angular momentum in radiative zones; 2) The impact of the mass losses in single and in close binary models.
We present results of full 3D hydrodynamical and radiative transfer simulations of the colliding stellar winds in the massive binary system η Carinae. We accomplish this by applying the SimpleX algorithm for 3D radiative transfer on an unstructured Voronoi-Delaunay grid to recent 3D smoothed particle hydrodynamics (SPH) simulations of the binary colliding winds. We use SimpleX to obtain detailed ionization fractions of hydrogen and helium, in 3D, at the resolution of the original SPH simulations. We investigate several computational domain sizes and Luminous Blue Variable primary star mass-loss rates. We furthermore present new methods of visualizing and interacting with output from complex 3D numerical simulations, including 3D interactive graphics and 3D printing. While we initially focus on η Car, the methods employed can be applied to numerous other colliding wind (WR 140, WR 137, WR 19) and dusty `pinwheel' (WR 104, WR 98a) binary systems. Coupled with 3D hydrodynamical simulations, SimpleX simulations have the potential to help determine the regions where various observed time-variable emission and absorption lines form in these unique objects.
HD5980
(2015)
HD5980 is a multiple system containing at least 3 very massive and luminous stars. Located in the Small Magellanic Cloud, it is an ideal system for studying the massive star structure and evolutionary processes in low-metallicity environments. Intensely observed over the past few decades, HD5980 is a treasure trove of information on stellar wind structure, on wind-wind collisions and on the formation of wind-blown circumstellar structures. In addition, its characteristics suggest that the eclipsing WR+LBV stars of the system are the product of quasihomogeneous chemical evolution, thus making them candidate pair production supernovae or GRB progenitors. This paper summarizes some of the outstanding results derived from half a century of observations and recent theoretical studies.
Ramírez Alegría, S. ; Chené, A.-N. ; Borissova, J. ; Kurtev, R. ; Navarro, C. ; Kuhn, M. ; Carballo-Bello, J. A.
We present the first physical characterization of the young open cluster VVVCL041. We spectroscopically observed the cluster main-sequence stellar population and a very-massive star candidate: WR62-2. CMFGEN modelling to our near-infrared spectra indicates that WR62-2 is a very luminous (10^6.4±0.2 L⊙)and massive (∼ 80M⊙) star.
We an optically-thick, transonic, steady wind model for a H-free Wolf-Rayet star. A bifurcation is found across a critical mass loss rate Mb. Slower winds M < Mb extend by several hydrostatic stellar radii, reproduce features of envelope in ation from Petrovic et al. (2006) and Gräfener et al. (2012), and are energetically unbound. This work is of particular interest for extended envelopes and winds, radiative hydrodynamic instabilities (eg. wind stagnation, clumping, etc.), and NLTE atmospheric models.
Morf, Carolyn C. ; Schürch, Eva ; Küfner, Albrecht ; Siegrist, Philip ; Vater, Aline ; Back, Mitja ; Mestel, Robert ; Schröder-Abé, Michela
The Pathological Narcissism Inventory (PNI) is a multidimensional measure for assessing grandiose and vulnerable features in narcissistic pathology. The aim of the present research was to construct and validate a German translation of the PNI and to provide further information on the PNI's nomological net. Findings from a first study confirm the psychometric soundness of the PNI and replicate its seven-factor first-order structure. A second-order structure was also supported but with several equivalent models. A second study investigating associations with a broad range of measures (DSM Axis I and II constructs, emotions, personality traits, interpersonal and dysfunctional behaviors, and well-being) supported the concurrent validity of the PNI. Discriminant validity with the Narcissistic Personality Inventory was also shown. Finally, in a third study an extension in a clinical inpatient sample provided further evidence that the PNI is a useful tool to assess the more pathological end of narcissism.
Abzug, um zu bleiben
(2011)
The evolution of massive stars is strongly influenced by their initial chemical composition. We have computed rapidly-rotating massive star models with low metallicity (∼1/50 Z⊙) that evolve chemically homogeneously and have optically-thin winds during the main sequence evolution. These luminous and hot stars are predicted to emit intense mid- and far-UV radiation, but without the broad emission lines that characterize WR stars with optically-thick winds. We show that such Transparent Wind UV-Intense (TWUIN) stars may be responsible for the high number of He ii ionizing photons observed in metal-poor dwarf galaxies, such as IZw 18. We find that these TWUIN stars are possible long-duration gamma-ray burst progenitors.
Yenesew, Abiy ; Induli, M. ; Derese, Solomon ; Midiwo, Jacob O. ; Heydenreich, Matthias ; Peter, Martin G. ; Akala, Hoseah M. ; Wangui, Julia ; Liyala, Pamela ; Waters, Norman C.
The ethyl acetate extract of the stem bark of Erythrina abyssinica showed anti-plasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 values of 7.9 +/- 1.1 and 5.3 +/- 0.7 mug/ml, respectively. From this extract, a new chalcone, 2,3,4,4'-tetrahydroxy-5- prenylchalcone (trivial name 5-prenylbutein) and a new flavanone, 4',7-dihydroxy-3'-methoxy-5'- prenylflavanone (trivial name, 5-deoxyabyssinin II) along with known flavonoids have been isolated as the anti- plasmodial principles. The structures were determined on the basis of spectroscopic evidence. (C) 2004 Elsevier Ltd. All rights reserved
Foster, William J. ; Garvie, Christopher L. ; Weiss, Anna M. ; Muscente, A. Drew ; Aberhan, Martin ; Counts, John W. ; Martindale, Rowan C.
The hyperthermal events of the Cenozoic, including the Paleocene-Eocene Thermal Maximum, provide an opportunity to investigate the potential effects of climate warming on marine ecosystems. Here, we examine the shallow benthic marine communities preserved in the late Cretaceous to Eocene strata on the Gulf Coastal Plain (United States). In stark contrast to the ecological shifts following the end-Cretaceous mass extinction, our data show that the early Cenozoic hyperthermals did not have a long-term impact on the generic diversity nor composition of the Gulf Coastal Plain molluscan communities. We propose that these communities were resilient to climate change because molluscs are better adapted to high temperatures than other taxa, as demonstrated by their physiology and evolutionary history. In terms of resilience, these communities differ from other shallow-water carbonate ecosystems, such as reef communities, which record significant changes during the early Cenozoic hyperthermals. These data highlight the strikingly different responses of community types, i.e., the almost imperceptible response of molluscs versus the marked turnover of foraminifera and reef faunas. The impact on molluscan communities may have been low because detrimental conditions did not devastate the entire Gulf Coastal Plain, allowing molluscs to rapidly recolonise vacated areas once harsh environmental conditions ameliorated.
Foster, William J. ; Garvie, Christopher L. ; Weiss, Anna M. ; Muscente, A. Drew ; Aberhan, Martin ; Counts, John W. ; Martindale, Rowan C.
The hyperthermal events of the Cenozoic, including the Paleocene-Eocene Thermal Maximum, provide an opportunity to investigate the potential effects of climate warming on marine ecosystems. Here, we examine the shallow benthic marine communities preserved in the late Cretaceous to Eocene strata on the Gulf Coastal Plain (United States). In stark contrast to the ecological shifts following the end-Cretaceous mass extinction, our data show that the early Cenozoic hyperthermals did not have a long-term impact on the generic diversity nor composition of the Gulf Coastal Plain molluscan communities. We propose that these communities were resilient to climate change because molluscs are better adapted to high temperatures than other taxa, as demonstrated by their physiology and evolutionary history. In terms of resilience, these communities differ from other shallow-water carbonate ecosystems, such as reef communities, which record significant changes during the early Cenozoic hyperthermals. These data highlight the strikingly different responses of community types, i.e., the almost imperceptible response of molluscs versus the marked turnover of foraminifera and reef faunas. The impact on molluscan communities may have been low because detrimental conditions did not devastate the entire Gulf Coastal Plain, allowing molluscs to rapidly recolonise vacated areas once harsh environmental conditions ameliorated.
Muiva-Mutisya, Lois M. ; Atilaw, Yoseph ; Heydenreich, Matthias ; Koch, Andreas ; Akala, Hoseah M. ; Cheruiyot, Agnes C. ; Brown, Matthew L. ; Irungu, Beatrice ; Okalebo, Faith A. ; Derese, Solomon ; Mutai, Charles ; Yenesew, Abiy
The CH2Cl2/MeOH (1:1) extract of the aerial parts of Tephrosia subtriflora afforded a new flavanonol, named subtriflavanonol (1), along with the known flavanone spinoflavanone B, and the known flavanonols MS-II (2) and mundulinol. The structures were elucidated by the use of NMR spectroscopy and mass spectrometry. The absolute configuration of the flavanonols was determined based on quantum chemical ECD calculations. In the antiplasmodial assay, compound 2 showed the highest activity against chloroquine-sensitive Plasmodiumfalciparum reference clones (D6 and 3D7), artemisinin-sensitive isolate (F32-TEM) as well as field isolate (KSM 009) with IC50 values 1.4-4.6M without significant cytotoxicity against Vero and HEp2 cell lines (IC50>100M). The new compound (1) showed weak antiplasmodial activity, IC50 12.5-24.2M, but also showed selective anticancer activity against HEp2 cell line (CC50 16.9M). [GRAPHICS] .
Kerubo, Leonidah Omosa ; Midiwo, Jacob Ogweno ; Derese, Solomon ; Langat, Moses K. ; Akala, Hoseah M. ; Waters, Norman C. ; Peter, Martin ; Heydenreich, Matthias
From the surface exudates of Senecio roseiflorus fourteen known methylated flavonoids and one phenol were isolated and characterized. The structures of these compounds were determined on the basis of their spectroscopic analysis. The surface exudate and the flavonoids isolated showed moderate to good antiplasmodial activity with 5,4'-dihydroxy-7-dimethoxyflavanone having the highest activity against chloroquine-sensitive (D6) and resistant (W2) strains of Plasmodium falciparum, with IC50 values of 3.2 +/- 0.8 and 4.4 +/- 0.01 mu g/mL respectively.
Andayi, Andrew W. ; Yenesew, Abiy ; Derese, Solomon ; Midiwo, Jacob O. ; Gitu, Peter M. ; Jondiko, Ogoche J. I. ; Akala, Hoseah M. ; Liyala, Pamela ; Wangui, Julia ; Waters, Norman C. ; Heydenreich, Matthias ; Peter, Martin G.
The acetone extracts of the root bark and stem bark of Erythrina sacleuxii showed antiplasmodial activities against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the acetone extract of the root bark afforded a new isoflavone, 7-hydroxy-4 -methoxy-3'- prenylisoflavone (trivial name 5-deoxy-3' - prenylbiochanin A) along with known isoflavonoids as the antiplasmodial principles. Flavonoids and isoflavonoids isolated from the stem bark of E. sucleuxii were also tested and showed antiplasmodial activities. The structures were determined on the basis of spectroscopic evidence
Peter, Martin G. ; Yenesew, Abiy ; Twinomuhwezi, Hannington ; Kabaru, Jacques M. ; Akala, Hoseah M. ; Kiremire, Bernard T. ; Heydenreich, Matthias ; Eyase, Fredrick ; Waters, Norman C. ; Walsh, Douglas S.
From the dichloromethane-methanol (1:1) extract of the seed pods of Derris trifoliata, a new flavanone derivative (S)-lupinifolin 4´-methyl ether was isolated. In addition, the known flavonoids lupinifolin and rotenone were identified. The structures were determined on the basis of spectroscopic evidence. Lupinfolin showed moderate in vitro antiplasmodial activity against the D6 (chloroquine-sensitive) and W2 (chloroquineresistant) strains of Plasmodium falciparum. The different parts of this plant showed larvicidal activities against Aedes aegypti and rotenoids were identified as the active principles.
Peter, Martin G. ; Muiva, Lois M. ; Yenesew, Abiy ; Derese, Solomon ; Heydenreich, Matthias ; Akala, Hoseah M. ; Eyase, Fredrick ; Waters, Norman C. ; Mutai, Charles ; Keriko, Joseph M. ; Walsh, Douglas S.
From the seedpods of Tephrosia elata, a new β-hydroxydihydrochalcone named (S)-elatadihydrochalcone was isolated. In addition, the known flavonoids obovatachalcone, obovatin, obovatin methyl ether and deguelin were identified. The structures were determined on the basis of spectroscopic evidence. The crude extract and the flavonoids obtained from the seedpods of this plant showed antiplasmodial activities. The literature NMR data on β-hydroxydihydrochalcones is reviewed and the identity of some of the compounds assigned β-hydroxydihydrochalcone skeleton is questioned.
The Atlantic subpolar gyre (SPG) is one of the main drivers of decadal climate variability in the North Atlantic. Here we analyze its dynamics in pre-industrial control simulations of 19 different comprehensive coupled climate models. The analysis is based on a recently proposed description of the SPG dynamics that found the circulation to be potentially bistable due to a positive feedback mechanism including salt transport and enhanced deep convection in the SPG center. We employ a statistical method to identify multiple equilibria in time series that are subject to strong noise and analyze composite fields to assess whether the bistability results from the hypothesized feedback mechanism. Because noise dominates the time series in most models, multiple circulation modes can unambiguously be detected in only six models. Four of these six models confirm that the intensification is caused by the positive feedback mechanism.
Making confident statements about the evolution of an ice-sheet shelf system with a numerical model requires the capability to reproduce the migration of the grounding line. Here we show that the shallow-ice approximation/shallow-shelf approximation hybrid-type Parallel Ice Sheet Model (PISM), with its recent improvements, is capable of modeling the grounding line motion in a perturbed ice-sheet shelf system. The model is set up according to the three-dimensional Marine Ice-Sheet Model Intercomparison Project (MISMIP3d), and simulations are carried out across a broad range of spatial resolutions. Using (1) a linear interpolation of the grounding line with locally interpolated basal friction and (2) an improved driving-stress computation across the grounding line, the reversibility of the grounding line (i.e. its retreat after an advance forced by a local perturbation of basal resistance) is captured by the model even at medium and low resolutions (Delta x > 10 km). The transient model response is qualitatively similar to that of higher-order models but reveals a higher initial sensitivity to perturbations on very short timescales. Our findings support the application of PISM to the Antarctic ice sheet from regional up to continental scales and on relatively low spatial resolutions.
Ein Dach über Europa
(2022)
Wo ist Deutschlands Raketenabwehr? Diese Frage rückte nach der völkerrechtswidrigen Annexion der Krim durch Russland 2014 in den Fokus der Presseberichterstattung. Für die Abwehr von ballistischen Raketen ist die Flugabwehrraketentruppe der Luftwaffe zuständig. Im Ost-West-Konflikt schützten rund 18.600 deutsche Soldaten im Rahmen der Integrierten NATO-Luftverteidigung die westliche Allianz vor Luftangriffen durch den Warschauer Pakt. Nach der Wiedervereinigung befand sich der Luftverteidigungsgürtel des Bündnisses nicht nur in einer geografisch wirkungslosen Position, sondern ihm fehlte auch die Daseinsberechtigung. Mit seiner Auflösung ging ein erheblicher Abbau von Personal und Material der Flugabwehrraketenverbände einher. Nach der Neuausrichtung der Bundeswehr 2012 blieb diesem Dienstbereich der Luftwaffe nur noch ein Geschwader mit rund 2.300 Dienstposten. Der alte Feind war weg – und Deutschland nach 1989/90 umgeben von Freunden und Verbündeten. Warum also sollte die Regierung in eine Fähigkeit investieren, die Deutschland für sich selbst nicht brauchte?
E-Learning Symposium 2018
(2018)
Keil, Reinhard ; Konert, Johannes ; Damnik, Gregor ; Gierl, Mark J. ; Proske, Antje ; Körndle, Hermann ; Narciss, Susanne ; Wahl, Marina ; Hölscher, Michael ; Mariani, Ennio ; Jaisli, Isabel ; Tscherejkina, Anna ; Morgiel, Anna ; Moebert, Tobias ; Herbstreit, Stephanie ; Mäker, Daniela ; Szalai, Cynthia ; Braun, Iris ; Kapp, Felix ; Hara, Tenshi C. ; Kubica, Tommy ; Stumpf, Sarah
In den vergangenen Jahren sind viele E-Learning-Innovationen entstanden. Einige davon wurden auf den vergangenen E-Learning Symposien der Universität Potsdam präsentiert: Das erste E-Learning Symposium im Jahr 2012 konzentrierte sich auf unterschiedliche Möglichkeiten der Studierendenaktivierung und Lehrgestaltung. Das Symposium 2014 rückte vor allem die Studierenden ins Zentrum der Aufmerksamkeit. Im Jahr 2016 kam es durch das Zusammengehen des Symposiums mit der DeLFI-Tagung zu einer Fokussierung auf technische Innovationen. Doch was ist aus den Leuchttürmen von gestern geworden, und brauchen wir überhaupt noch neue Leuchttürme? Das Symposium setzt sich in diesem Jahr unter dem Motto „Innovation und Nachhaltigkeit – (k)ein Gegensatz?“ mit mediengestützten Lehr- und Lernprozessen im universitären Kontext auseinander und reflektiert aktuelle technische sowie didaktische Entwicklungen mit Blick auf deren mittel- bis langfristigen Einsatz in der Praxis.
Dieser Tagungsband zum E-Learning Symposium 2018 an der Universität Potsdam beinhaltet eine Mischung von Forschungs- und Praxisbeiträgen aus verschiedenen Fachdisziplinen und eröffnet vielschichtige Perspektiven auf das Thema E-Learning. Dabei werden die Vielfalt der didaktischen Einsatzszenarien als auch die Potentiale von Werk-zeugen und Methoden der Informatik in ihrem Zusammenspiel beleuchtet.
In seiner Keynote widmet sich Reinhard Keil dem Motto des Symposiums und geht der Nachhaltigkeit bei E-Learning-Projekten auf den Grund. Dabei analysiert und beleuchtet er anhand seiner über 15-jährigen Forschungspraxis die wichtigsten Wirkfaktoren und formuliert Empfehlungen zur Konzeption von E-Learning-Projekten. Im Gegensatz zu rein auf Kostenersparnis ausgerichteten (hochschul-)politischen Forderungen proklamiert er den Ansatz der hypothesengeleiteten Technikgestaltung, in der Nachhaltigkeit als Leitfrage oder Forschungsstrategie verstanden werden kann. In eine ähnliche Richtung geht der Beitrag von Iris Braun et al., die über Erfolgsfaktoren beim Einsatz von Audience Response Systemen in der universitären Lehre berichten.
Ein weiteres aktuelles Thema, sowohl für die Bildungstechnologie als auch in den Bildungswissenschaften allgemein, ist die Kompetenzorientierung und –modellierung. Hier geht es darum (Problemlöse-)Fähigkeiten gezielt zu beschreiben und in den Mittelpunkt der Lehre zu stellen. Johannes Konert stellt in einem eingeladenen Vortrag zwei Projekte vor, die den Prozess beginnend bei der Definition von Kompetenzen, deren Modellierung in einem semantischen maschinenlesbaren Format bis hin zur Erarbeitung von Methoden zur Kompetenzmessung und der elektronischen Zertifizierung aufzeigen. Dabei geht er auf technische Möglichkeiten, aber auch Grenzen ein. Auf einer spezifischeren Ebene beschäftigt sich Sarah Stumpf mit digitalen bzw. mediendidaktischen Kompetenzen im Lehramtsstudium und stellt ein Framework für die Förderung ebensolcher Kompetenzen bei angehenden Lehrkräften vor.
Der Einsatz von E-Learning birgt noch einige Herausforderungen. Dabei geht es oft um die Verbindung von Didaktik und Technik, den Erhalt von Aufmerksamkeit oder den Aufwand für das Erstellen von interaktiven Lehr- und Lerninhalten. Drei Beiträge in diesem Tagungsband beschäftigen sich mit dieser Thematik in unterschiedlichen Kontexten und zeigen Best-Practices und Lösungsansätze auf: Der Beitrag von Martina Wahl und Michael Hölscher behandelt den besonderen Kontext von Blended Learning-Szenarien in berufsbegleitenden Studiengängen. Um die Veröffentlichung eines global frei verfügbaren Onlinekurses abseits der großen MOOC Plattformen und den didaktischen Herausforderungen auch hinsichtlich der Motivation geht es im Beitrag von Ennio Marani und Isabel Jaisli. Schließlich schlagen Gregor Damnik et al. die automatische Erzeugung von Aufgaben zur Erhöhung von Interaktivität und Adaptivität in digitalen Lernressourcen vor, um den teilweise erheblichen Erstellungsaufwand zu reduzieren.
Zum Thema E-Learning zählen auch immer mobile Apps bzw. Spiele. Gleich zwei Beiträge beschäftigen sich mit dem Einsatz von E-Learning-Tools im Gesundheitskontext: Anna Tscherejkina und Anna Morgiel stellen in ihrem Beitrag Minispiele zum Training von sozio-emotionalen Kompetenzen für Menschen mit Autismus vor, und Stephanie Herbstreit et al. berichten vom Einsatz einer mobilen Lern-App zur Verbesserung von klinisch-praktischem Unterricht.
Troll, K. ; Kulkarni, Amit ; Wang, W. ; Darko, C. ; Koumba, A. M. Bivigou ; Laschewsky, André ; Müller-Buschbaum, Peter ; Papadakis, Christine M.
Cordeiro, Andre M. ; Andrade, Luis ; Monteiro, Catarina C. ; Leitao, Guilherme ; Wigge, Philip Anthony ; Saibo, Nelson J. M.
Review exploring the regulation of PHYTOCHROME-INTERACTING FACTORS by light, their role in abiotic stress tolerance and plant architecture, and their influence on crop productivity.
Light is a key determinant for plant growth, development, and ultimately yield. Phytochromes, red/far-red photoreceptors, play an important role in plant architecture, stress tolerance, and productivity. In the model plant Arabidopsis, it has been shown that PHYTOCHROME-INTERACTING FACTORS (PIFs; bHLH transcription factors) act as central hubs in the integration of external stimuli to regulate plant development. Recent studies have unveiled the importance of PIFs in crops. They are involved in the modulation of plant architecture and productivity through the regulation of cell division and elongation in response to different environmental cues. These studies show that different PIFs have overlapping but also distinct functions in the regulation of plant growth. Therefore, understanding the molecular mechanisms by which PIFs regulate plant development is crucial to improve crop productivity under both optimal and adverse environmental conditions. In this review, we discuss current knowledge of PIFs acting as integrators of light and other signals in different crops, with particular focus on the role of PIFs in responding to different environmental conditions and how this can be used to improve crop productivity.
Sommer, C. ; Garbusow, Maria ; Juenger, E. ; Pooseh, S. ; Bernhardt, Nadine ; Birkenstock, J. ; Schad, Daniel ; Jabs, B. ; Gloeckler, T. ; Huys, Quentin J. M. ; Heinz, A. ; Smolka, Michael N. ; Zimmermann, Ulrich S.
Alcohol-related cues acquire incentive salience through Pavlovian conditioning and then can markedly affect instrumental behavior of alcohol-dependent patients to promote relapse. However, it is unclear whether similar effects occur with alcohol-unrelated cues. We tested 116 early-abstinent alcohol-dependent patients and 91 healthy controls who completed a delay discounting task to assess choice impulsivity, and a Pavlovian-to-instrumental transfer (PIT) paradigm employing both alcohol-unrelated and alcohol-related stimuli. To modify instrumental choice behavior, we tiled the background of the computer screen either with conditioned stimuli (CS) previously generated by pairing abstract pictures with pictures indicating monetary gains or losses, or with pictures displaying alcohol or water beverages. CS paired to money gains and losses affected instrumental choices differently. This PIT effect was significantly more pronounced in patients compared to controls, and the group difference was mainly driven by highly impulsive patients. The PIT effect was particularly strong in trials in which the instrumental stimulus required inhibition of instrumental response behavior and the background CS was associated to monetary gains. Under that condition, patients performed inappropriate approach behavior, contrary to their previously formed behavioral intention. Surprisingly, the effect of alcohol and water pictures as background stimuli resembled that of aversive and appetitive CS, respectively. These findings suggest that positively valenced background CS can provoke dysfunctional instrumental approach behavior in impulsive alcohol-dependent patients. Consequently, in real life they might be easily seduced by environmental cues to engage in actions thwarting their long-term goals. Such behaviors may include, but are not limited to, approaching alcohol.
Tadjoung Waffo, Armel Franklin ; Yesildag, Cigdem ; Caserta, Giorgio ; Katz, Sagie ; Zebger, Ingo ; Lensen, Marga C. ; Wollenberger, Ulla ; Scheller, Frieder W. ; Altintas, Zeynep
This study aims to develop a rapid, sensitive and cost-effective biomimetic electrochemical sensor for artemisinin determination in plant extracts and for pharmacokinetic studies. A novel molecularly imprinted polymer (MIP)based electrochemical sensor was developed by electropolymerization of o-phenylenediamine (o-PD) in the presence of artemisinin on gold wire surface for sensitive detection of artemisinin. The experimental parameters, including selection of functional monomer, polymerization conditions, template extraction after polymerization, influence of pH and buffer were all optimized. Every step of imprinted film synthesis were evaluated by employing voltammetry techniques, surface-enhanced infrared absorption spectroscopy (SEIRAS) and atomic force microscopy (AFM). The specificity was further evaluated by investigating non-specific artemisinin binding on non-imprinted polymer (NIP) surfaces and an imprinting factor of 6.8 was achieved. The artemisinin imprinted polymers using o-PD as functional monomer have provided highly stable and effective binding cavities for artemisinin. Cross-reactivity studies with drug molecules showed that the MIPs are highly specific for artemisinin. The influence of matrix effect was further investigated both in artificial plant matrix and diluted human serum. The results revealed a high affinity of artemisinin-MIP with dissociation constant of 7.3 x 10(-9) M and with a detection limit of 0.01 mu M and 0.02 mu M in buffer and plant matrix, respectively.
McNulty, Margaret A. ; Goupil, Brad A. ; Albarado, Diana C. ; Castaño-Martinez, Teresa ; Ambrosi, Thomas H. ; Puh, Spela ; Schulz, Tim Julius ; Schürmann, Annette ; Morrison, Christopher D. ; Laeger, Thomas
Background: Dietary protein restriction is emerging as an alternative approach to treat obesity and glucose intolerance because it markedly increases plasma fibroblast growth factor 21 (FGF21) concentrations. Similarly, dietary restriction of methionine is known to mimic metabolic effects of energy and protein restriction with FGF21 as a required mechanism. However, dietary protein has been shown to be required for normal bone growth, though there is conflicting evidence as to the influence of dietary protein restriction on bone remodeling. The purpose of the current study was to evaluate the effect of dietary protein and methionine restriction on bone in lean and obese mice, and clarify whether FGF21 and general control nonderepressible 2 (GCN2) kinase, that are part of a novel endocrine pathway implicated in the detection of protein restriction, influence the effect of dietary protein restriction on bone.
Methods: Adult wild-type (WT) or Fgf21 KO mice were fed a normal protein (18 kcal%; CON) or low protein (4 kcal%; LP) diet for 2 or 27 weeks. In addition, adult WT or Gcn2 KO mice were fed a CON or LP diet for 27 weeks. Young New Zealand obese (NZO) mice were placed on high-fat diets that provided protein at control (16 kcal%; CON), low levels (4 kcal%) in a high-carbohydrate (LP/HC) or high-fat (LP/HF) regimen, or on high-fat diets (protein, 16 kcal%) that provided methionine at control (0.86%; CON-MR) or low levels (0.17%; MR) for up to 9 weeks. Long bones from the hind limbs of these mice were collected and evaluated with micro-computed tomography (mu CT) for changes in trabecular and cortical architecture and mass.
Results: In WT mice the 27-week LP diet significantly reduced cortical bone, and this effect was enhanced by deletion of Fgf21 but not Gcn2. This decrease in bone did not appear after 2 weeks on the LP diet. In addition, Fgf21 KO mice had significantly less bone than their WT counterparts. In obese NZO mice dietary protein and methionine restriction altered bone architecture. The changes were mediated by FGF21 due to methionine restriction in the presence of cystine, which did not increase plasma FGF21 levels and did not affect bone architecture.
Conclusions: This study provides direct evidence of a reduction in bone following long-term dietary protein restriction in a mouse model, effects that appear to be mediated by FGF21.
Estimating global mean sea-level rise and its uncertainties by 2100 and 2300 from an expert survey
(2020)
Horton, Benjamin P. ; Khan, Nicole S. ; Cahill, Niamh ; Lee, Janice S. H. ; Shaw, Timothy A. ; Garner, Andra J. ; Kemp, Andrew C. ; Engelhart, Simon E. ; Rahmstorf, Stefan
Sea-level rise projections and knowledge of their uncertainties are vital to make informed mitigation and adaptation decisions. To elicit projections from members of the scientific community regarding future global mean sea-level (GMSL) rise, we repeated a survey originally conducted five years ago. Under Representative Concentration Pathway (RCP) 2.6, 106 experts projected a likely (central 66% probability) GMSL rise of 0.30-0.65 m by 2100, and 0.54-2.15 m by 2300, relative to 1986-2005. Under RCP 8.5, the same experts projected a likely GMSL rise of 0.63-1.32 m by 2100, and 1.67-5.61 m by 2300. Expert projections for 2100 are similar to those from the original survey, although the projection for 2300 has extended tails and is higher than the original survey. Experts give a likelihood of 42% (original survey) and 45% (current survey) that under the high-emissions scenario GMSL rise will exceed the upper bound (0.98 m) of the likely range estimated by the Fifth Assessment Report of the Intergovernmental Panel on Climate Change, which is considered to have an exceedance likelihood of 17%. Responses to open-ended questions suggest that the increases in upper-end estimates and uncertainties arose from recent influential studies about the impact of marine ice cliff instability on the meltwater contribution to GMSL rise from the Antarctic Ice Sheet.
Hoke, Gregory D. ; Garzione, Carmala N. ; Araneo, Diego C. ; Latorre, Claudio ; Strecker, Manfred ; Williams, Kendra J.
Stable isotope altimetry is a useful tool for estimating paleoelevation in sedimentary records. Yet questions remain regarding how source moisture, climate, and local topography can influence these estimates. Here we present stable isotope altimetry results on late Quaternary pedogenic carbonates of known elevation on both flanks of the Andean orogen at 33 degrees S. We measured delta O-18 values of pedogenic carbonates and river water samples from small drainages at regular elevation increments within the Rio Aconcagua (Chile) and Rio Mendoza (Argentina) catchments. The delta O-18 values of river waters correlate well with elevation and show similar isotopic gradients between the Chilean (-3.7 parts per thousand/km) and Argentine (-4.8 parts per thousand/km) sides of the range. Uncertainties associated with scatter in the river water data and assumptions about the temperature of carbonate formation indicate that elevation estimates have 1 sigma errors of 350-450 m. We estimate the isotopic composition of soil water from pedogenic carbonates on both sides of the range by assuming mean annual temperatures based the modern temperature lapse rate from meteorological station data. Combined, our data show that stable isotope altimetry produces reasonable estimates of modern elevation, with the majority of our samples (60%) within the 1 sigma uncertainties and 77% within 2 sigma.
McNulty, Margaret A. ; Goupil, Brad A. ; Albarado, Diana C. ; Castaño-Martinez, Teresa ; Ambrosi, Thomas H. ; Puh, Spela ; Schulz, Tim Julius ; Schürmann, Annette ; Morrison, Christopher D. ; Laeger, Thomas
Background: Dietary protein restriction is emerging as an alternative approach to treat obesity and glucose intolerance because it markedly increases plasma fibroblast growth factor 21 (FGF21) concentrations. Similarly, dietary restriction of methionine is known to mimic metabolic effects of energy and protein restriction with FGF21 as a required mechanism. However, dietary protein has been shown to be required for normal bone growth, though there is conflicting evidence as to the influence of dietary protein restriction on bone remodeling. The purpose of the current study was to evaluate the effect of dietary protein and methionine restriction on bone in lean and obese mice, and clarify whether FGF21 and general control nonderepressible 2 (GCN2) kinase, that are part of a novel endocrine pathway implicated in the detection of protein restriction, influence the effect of dietary protein restriction on bone.
Methods: Adult wild-type (WT) or Fgf21 KO mice were fed a normal protein (18 kcal%; CON) or low protein (4 kcal%; LP) diet for 2 or 27 weeks. In addition, adult WT or Gcn2 KO mice were fed a CON or LP diet for 27 weeks. Young New Zealand obese (NZO) mice were placed on high-fat diets that provided protein at control (16 kcal%; CON), low levels (4 kcal%) in a high-carbohydrate (LP/HC) or high-fat (LP/HF) regimen, or on high-fat diets (protein, 16 kcal%) that provided methionine at control (0.86%; CON-MR) or low levels (0.17%; MR) for up to 9 weeks. Long bones from the hind limbs of these mice were collected and evaluated with micro-computed tomography (mu CT) for changes in trabecular and cortical architecture and mass.
Results: In WT mice the 27-week LP diet significantly reduced cortical bone, and this effect was enhanced by deletion of Fgf21 but not Gcn2. This decrease in bone did not appear after 2 weeks on the LP diet. In addition, Fgf21 KO mice had significantly less bone than their WT counterparts. In obese NZO mice dietary protein and methionine restriction altered bone architecture. The changes were mediated by FGF21 due to methionine restriction in the presence of cystine, which did not increase plasma FGF21 levels and did not affect bone architecture.
Conclusions: This study provides direct evidence of a reduction in bone following long-term dietary protein restriction in a mouse model, effects that appear to be mediated by FGF21.
del Papa, C. ; Hongn, Fernando D. ; Powell, J. ; Payrola, P. ; Do Campo, M. ; Strecker, Manfred ; Petrinovic, I. ; Schmitt, A. K. ; Pereyra, R.
Two end-member models have been proposed for the Paleogene Andean foreland: a simple W-E migrating foreland model and a broken-foreland model. We present new stratigraphic, sedimentological and structural data from the Paleogene Quebrada de los Colorados (QLC) Formation, in the Eastern Cordillera, with which to test these two different models. Basin-wide unconformities, growthstrata and changes in provenance indicate deposition of the QLC Formation in a tectonically active basin. Both west- and east-vergent structures, rooted in the basement, controlled the deposition and distribution of the QLC Formation from the Middle Eocene to the Early Miocene. The provenance analysis indicates that the main source areas were basement blocks, like the Paleozoic Oire Eruptive Complex, uplifted during Paleogene shortening, and that delimits the eastern boundary of the present-day intraorogenic Puna plateau. A comparison of the QLC sedimentary basin-fill pattern with those of adjacent Paleogene basins in the Puna plateau and in the Santa Barbara System highlights the presence of discrete depozones. These reflect the early compartmentalization of the foreland, rather than a stepwise advance of the deformation front of a thrust belt. The early Tertiary foreland of the southern central Andes is represented by a ca. 250-km-wide area comprising several deformation zones (Arizaro, Macon, Copalayo and Calchaqui) in which doubly vergent or asymmetric structures, rooted in the basement, were generated. Hence, classical foreland model is difficult to apply in this Paleogene basin; and our data and interpretation agree with a broken-foreland model.
Deng, Zijun ; Wang, Weiwei ; Xua, Xun ; Gould, Oliver E. C. ; Kratz, Karl ; Ma, Nan ; Lendlein, Andreas
Stem cells are capable of sensing and processing environmental inputs, converting this information to output a specific cell lineage through signaling cascades. Despite the combinatorial nature of mechanical, thermal, and biochemical signals, these stimuli have typically been decoupled and applied independently, requiring continuous regulation by controlling units. We employ a programmable polymer actuator sheet to autonomously synchronize thermal and mechanical signals applied to mesenchymal stem cells (MSC5). Using a grid on its underside, the shape change of polymer sheet, as well as cell morphology, calcium (Ca2+) influx, and focal adhesion assembly, could be visualized and quantified. This paper gives compelling evidence that the temperature sensing and mechanosensing of MSC5 are interconnected via intracellular Ca2+. Up-regulated Ca2+ levels lead to a remarkable alteration of histone H3K9 acetylation and activation of osteogenic related genes. The interplay of physical, thermal, and biochemical signaling was utilized to accelerate the cell differentiation toward osteogenic lineage. The approach of programmable bioinstructivity provides a fundamental principle for functional biomaterials exhibiting multifaceted stimuli on differentiation programs. Technological impact is expected in the tissue engineering of periosteum for treating bone defects.
Estimating global mean sea-level rise and its uncertainties by 2100 and 2300 from an expert survey
(2020)
Horton, Benjamin P. ; Khan, Nicole S. ; Cahill, Niamh ; Lee, Janice S. H. ; Shaw, Timothy A. ; Garner, Andra J. ; Kemp, Andrew C. ; Engelhart, Simon E. ; Rahmstorf, Stefan
Sea-level rise projections and knowledge of their uncertainties are vital to make informed mitigation and adaptation decisions. To elicit projections from members of the scientific community regarding future global mean sea-level (GMSL) rise, we repeated a survey originally conducted five years ago. Under Representative Concentration Pathway (RCP) 2.6, 106 experts projected a likely (central 66% probability) GMSL rise of 0.30-0.65 m by 2100, and 0.54-2.15 m by 2300, relative to 1986-2005. Under RCP 8.5, the same experts projected a likely GMSL rise of 0.63-1.32 m by 2100, and 1.67-5.61 m by 2300. Expert projections for 2100 are similar to those from the original survey, although the projection for 2300 has extended tails and is higher than the original survey. Experts give a likelihood of 42% (original survey) and 45% (current survey) that under the high-emissions scenario GMSL rise will exceed the upper bound (0.98 m) of the likely range estimated by the Fifth Assessment Report of the Intergovernmental Panel on Climate Change, which is considered to have an exceedance likelihood of 17%. Responses to open-ended questions suggest that the increases in upper-end estimates and uncertainties arose from recent influential studies about the impact of marine ice cliff instability on the meltwater contribution to GMSL rise from the Antarctic Ice Sheet.
Schildgen, Taylor F. ; Cosentino, D. ; Bookhagen, Bodo ; Niedermann, Samuel ; Yildirim, C. ; Echtler, Helmut Peter ; Wittmann, Hella ; Strecker, Manfred
Uplifted Neogene marine sediments and Quaternary fluvial terraces in the Mut Basin, southern Turkey, reveal a detailed history of surface uplift along the southern margin of the Central Anatolian plateau from the Late Miocene to the present. New surface exposure ages (Be-10, Al-26, and Ne-21) of gravels capping fluvial strath terraces located between 28 and 135 m above the Goksu River in the Mut Basin yield ages ranging from ca. 25 to 130 ka, corresponding to an average incision rate of 0.52 to 0.67 mm/yr. Published biostratigraphic data combined with new interpretations of the fossil assemblages from uplifted marine sediments reveal average uplift rates of 0.25 to 0.37 mm/yr since Late Miocene time (starting between 8 and 5.45 Ma), and 0.72 to 0.74 mm/yr after 1.66 to 1.62 Ma. Together with the terrace abandonment ages, the data imply 0.6 to 0.7 mm/yr uplift rates from 1.6 Ma to the present. The different post-Late Miocene and post-1.6 Ma uplift rates can imply increasing uplift rates through time, or multi-phased uplift with slow uplift or subsidence in between. Longitudinal profiles of rivers in the upper catchment of the Mut and Ermenek basins show no apparent lithologic or fault control on some knickpoints that occur at 1.2 to 1.5 km elevation, implying a transient response to a change in uplift rates. Projections of graded upper relict channel segments to the modern outlet, together with constraints from uplifted marine sediments, show that a slower incision/uplift rate of 0.1 to 0.2 mm/yr preceded the 0.7 mm/yr uplift rate. The river morphology and profile projections therefore reflect multi-phased uplift of the plateau margin, rather than steadily increasing uplift rates. Multi-phased uplift can be explained by lithospheric slab break-off and possibly also the arrival of the Eratosthenes Seamount at the collision zone south of Cyprus.
Schildgen, Taylor F. ; Cosentino, D. ; Caruso, A. ; Buchwaldt, Robert ; Yildirim, C. ; Bowring, S. A. ; Rojay, B. ; Echtler, Helmut Peter ; Strecker, Manfred
The southwest margin of the Central Anatolian Plateau has experienced multiple phases of topographic growth, including the formation of localized highs prior to the Late Miocene that were later affected by wholesale uplift of the plateau margin. Our new biostratigraphic data limit the age of uplifted marine sediments at the southwest plateau margin at 1.5 km elevation to <7.17 Ma, and regional lithostratigraphic correlations imply that the age is <6.7 Ma. Single-grain CA-TIMS U-Pb zircon analyses from a reworked ash within the marine sediments yield dates as young as 10.6 Ma, indicating a maximum age that is consistent with the biostratigraphy. Our structural measurements within the uplifted region and fault inversion modeling agree with previous findings in surrounding regions, with early contraction followed by strike-slip and extensional deformation during uplift. Focal mechanisms from shallow earthquakes show that the extensional phase has continued to the present. Broad similarities in the change in the tectonic stress regime (after 8 Ma) and the onset of surface uplift (after 7 Ma) imply that deep-seated process(es) caused post-7 Ma uplift. The geometry of lithospheric slabs beneath the plateau margin, Pliocene to recent alkaline volcanism, and the uplift pattern with accompanying normal faulting point toward slab tearing and localized heating at the base of the lithosphere as a probable mechanism for post-7 Ma uplift of the southwest margin. Considering previous work in the region, there appears to be an important link between slab dynamics and surface uplift throughout the Anatolian Plateau’s southern margin.
The Cenozoic East African Rift System (EARS) is an exceptional example of active continental extension, providing opportunities for furthering our understanding of hydrocarbon plays within rifts. It is divided into structurally distinct western and eastern branches. The western branch comprises deep rift basins separated by transfer zones, commonly localised onto pre-existing structures, offering good regional scale hydrocarbon traps. At a basin-scale, local discrete inherited structures might also play an important role on fault localisation and hydrocarbon distribution. Here, we consider the evolution of the Central basin of the Malawi Rift, in particular the influence of pre-existing structural fabrics. Integrating basin-scale multichannel 2D, and high resolution seismic datasets we constrain the border, Mlowe-Nkhata, fault system (MNF) to the west of the basin and smaller Mbamba fault (MF) to the east and document their evolution. Intra basin structures define a series of horsts, which initiated as convergent transfers, along the basin axis. The horsts are offset along a NE SW striking transfer fault parallel to and along strike of the onshore Karoo (Permo-Triassic) Ruhuhu graben. Discrete pre-existing structures probably determined its location and, oriented obliquely to the extension orientation it accommodated predominantly strike-slip deformation, with more slowly accrued dip-slip. To the north of this transfer fault, the overall basin architecture is asymmetric, thickening to the west throughout; while to the south, an initially symmetric graben architecture became increasingly asymmetric in sediment distribution as strain localised onto the western MNF. The presence of the axial horst increasingly focussed sediment supply to the west. As the transfer fault increased its displacement, so this axial supply was interrupted, effectively starving the south-east while ponding sediments between the western horst margin and the transfer fault. This asymmetric bathymetry and partitioned sedimentation continues to the present-day, overprinting the early basin symmetry and configuration. Sediments deposited earlier become increasingly dissected and fault juxtapositions changed at a small (10-100 m) scale. The observed influence of basin-scale transfer faults on sediment dispersal and fault compartmentalization due to pre-existing structures oblique to the extension orientation is relevant to analogous exploration settings. (C) 2016 Elsevier Ltd. All rights reserved.
We develop a model of optimal carbon taxation and redistribution taking into account horizontal equity concerns by considering heterogeneous energy efficiencies. By deriving first- and second-best rules for policy instruments including carbon taxes, transfers and energy subsidies, we then investigate analytically how horizontal equity is considered in the social welfare maximizing tax structure. We calibrate the model to German household data and a 30 percent emission reduction goal. Our results show that energy-intensive households should receive more redistributive resources than energy-efficient households if and only if social inequality aversion is sufficiently high. We further find that redistribution of carbon tax revenue via household-specific transfers is the first-best policy. Equal per-capita transfers do not suffer from informational problems, but increase mitigation costs by around 15 percent compared to the first- best for unity inequality aversion. Adding renewable energy subsidies or non-linear energy subsidies, reduces mitigation costs further without relying on observability of households’ energy efficiency.
Research on corporate entrepreneurship—venturing activities by established corporations—has received increasing scholarly attention. We employ bibliometric methods to analyze the literature on corporate entrepreneurship published over the last five decades. Based on the results of citation and co-citation analyses, we reveal central works in the field and how they are interconnected. We investigate the underlying intellectual structure of the field. Our findings provide evidence of the growing maturity and interdisciplinarity of corporate entrepreneurship and provide insight into research themes. We find that resource-based view and its extensions still remain the predominant theoretical perspectives in the field. Drawing on these findings, we suggest directions for future research.
Fox, Andrew J. ; Wakker, Bart P. ; Barger, Kathleen A. ; Hernandez, Audra K. ; Richter, Philipp ; Lehner, Nicolas ; Bland-Hawthorn, Joss ; Charlton, Jane C. ; Westmeier, Tobias ; Thom, Christopher ; Tumlinson, Jason ; Misawa, Toru ; Howk, J. Christopher ; Haffner, L. Matthew ; Ely, Justin ; Rodriguez-Hidalgo, Paola ; Kumari, Nimisha
Dynamic interactions between the two Magellanic Clouds have flung large quantities of gas into the halo of the Milky Way. The result is a spectacular arrangement of gaseous structures, including the Magellanic Stream, the Magellanic Bridge, and the Leading Arm (collectively referred to as the Magellanic System). In this third paper of a series studying the Magellanic gas in absorption, we analyze the gas ionization level using a sample of 69 Hubble Space Telescope/Cosmic Origins Spectrograph sightlines that pass through or within 30 degrees of the 21 cm emitting regions. We find that 81% (56/69) of the sightlines show UV absorption at Magellanic velocities, indicating that the total cross-section of the Magellanic System is approximate to 11,000 deg(2), or around one-quarter of the entire sky. Using observations of the Si III/Si II ratio together with Cloudy photoionization modeling, we calculate the total gas mass (atomic plus ionized) of the Magellanic System to be approximate to 2.0 x 10(9) M-circle dot (d/55 kpc)(2), with the ionized gas contributing around three times as much mass as the atomic gas. This is larger than the current-day interstellar H I mass of both Magellanic Clouds combined, indicating that they have lost most of their initial gas mass. If the gas in the Magellanic System survives to reach the Galactic disk over its inflow time of similar to 0.5-1.0 Gyr, it will represent an average inflow rate of similar to 3.7-6.7 M-circle dot yr(-1), potentially raising the Galactic star formation rate. However, multiple signs of an evaporative interaction with the hot Galactic corona indicate that the Magellanic gas may not survive its journey to the disk fully intact and will instead add material to (and cool) the corona.
Richter, Philipp ; Nuza, S. E. ; Fox, Andrew J. ; Wakker, Bart P. ; Lehner, N. ; Ben Bekhti, Nadya ; Fechner, Cora ; Wendt, Martin ; Howk, J. Christopher ; Muzahid, S. ; Ganguly, R. ; Charlton, Jane C.
Context. The Milky Way is surrounded by large amounts of diffuse gaseous matter that connects the stellar body of our Galaxy with its large-scale Local Group (LG) environment. Aims. To characterize the absorption properties of this circumgalactic medium (CGM) and its relation to the LG we present the so-far largest survey of metal absorption in Galactic high-velocity clouds (HVCs) using archival ultraviolet (UV) spectra of extragalactic background sources. The UV data are obtained with the Cosmic Origins Spectrograph (COS) onboard the Hubble Space Telescope (HST) and are supplemented by 21 cm radio observations of neutral hydrogen. Methods. Along 270 sightlines we measure metal absorption in the lines of Si II, Si III, C II, and C IV and associated H I 21 cm emission in HVCs in the velocity range vertical bar v(LSR)vertical bar = 100-500 km s(-1). With this unprecedented large HVC sample we were able to improve the statistics on HVC covering fractions, ionization conditions, small-scale structure, CGM mass, and inflow rate. For the first time, we determine robustly the angular two point correlation function of the high-velocity absorbers, systematically analyze antipodal sightlines on the celestial sphere, and compare the HVC absorption characteristics with that of damped Lyman alpha absorbers (DLAs) and constrained cosmological simulations of the LG (CLUES project).
Quantification of subsurface water fluxes based on the one dimensional solution to the heat transport equation depends on the accuracy of measured subsurface temperatures. The influence of temperature probe setup on the accuracy of vertical water flux calculation was systematically evaluated in this experimental study. Four temperature probe setups were installed into a sand box experiment to measure temporal highly resolved vertical temperature profiles under controlled water fluxes in the range of +/- 1.3 md(-1). Pass band filtering provided amplitude differences and phase shifts of the diurnal temperature signal varying with depth depending on water flux. Amplitude ratios of setups directly installed into the saturated sediment significantly varied with sand box hydraulic gradients. Amplitude ratios provided an accurate basis for the analytical calculation of water flow velocities, which matched measured flow velocities. Calculated flow velocities were sensitive to thermal properties of saturated sediment and to temperature sensor spacing, but insensitive to thermal dispersivity equal to solute dispersivity. Amplitude ratios of temperature probe setups indirectly installed into piezometer pipes were influenced by thermal exchange processes within the pipes and significantly varied with water flux direction only. Temperature time lags of small sensor distances of all setups were found to be insensitive to vertical water flux.
EC 22536-5304
(2021)
Helium-burning hot subdwarf stars of spectral types O and B (sdO/B) are thought to be produced through various types of binary interactions. The helium-rich hot subdwarf star EC 22536-5304 was recently found to be extremely enriched in lead. Here, we show that EC 22536-5304 is a binary star with a metal-poor subdwarf F-type (sdF) companion. We performed a detailed analysis of high-resolution SALT/HRS and VLT/UVES spectra, deriving metal abundances for the hot subdwarf, as well as atmospheric parameters for both components. Because we consider the contribution of the sdF star, the derived lead abundance for the sdOB, + 6.3 +/- 0.3 dex relative to solar, is even higher than previously thought. We derive T-eff = 6210 +/- 70 K, log g = 4.64 +/- 0.10, [FE/H] = - 1.95 +/- 0.04, and [alpha/Fe] = + 0.40 +/- 0.04 for the sdF component. Radial velocity variations, although poorly sampled at present, indicate that the binary system has a long orbital period of about 457 days. This suggests that the system was likely formed through stable Roche lobe overflow (RLOF). A kinematic analysis shows that EC 22536-5304 is on an eccentric orbit around the Galactic centre. This, as well as the low metallicity and strong alpha enhancement of the sdF-type companion, indicate that EC 22536-5304 is part of the Galactic halo or metal-weak thick disc. As the first long-period hot subdwarf binary at [FE/H] less than or similar to- 1, EC 22536-5304 may help to constrain the RLOF mechanism for mass transfer from low-mass, low-metallicity red giant branch (RGB) stars to main-sequence companions.
Peres, Tanara V. ; Eyng, Helena ; Lopes, Samantha C. ; Colle, Dirleise ; Goncalves, Filipe M. ; Venske, Debora K. R. ; Lopes, Mark W. ; Ben, Juliana ; Bornhorst, Julia ; Schwerdtle, Tanja ; Aschner, Michael A. ; Farina, Marcelo ; Prediger, Rui D. ; Leal, Rodrigo B.
Exposure to high manganese (Mn) levels may damage the basal ganglia, leading to a syndrome analogous to Parkinson's disease, with motor and cognitive impairments. The molecular mechanisms underlying Mn neurotoxicity, particularly during development, still deserve further investigation. Herein, we addressed whether early-life Mn exposure affects motor coordination and cognitive function in adulthood and potential underlying mechanisms. Male Wistar rats were exposed intraperitoneally to saline (control) or MnCl2 (5, 10 or 20 mg/kg/day) from post-natal day (PND) 8-12. Behavioral tests were performed on PND 60-65 and biochemical analysis in the striatum and hippocampus were performed on PND14 or PND70. Rats exposed to Mn (10 and 20 mg/kg) performed significantly worse on the rotarod test than controls indicating motor coordination and balance impairments. The object and social recognition tasks were used to evaluate short-term memory. Rats exposed to the highest Mn dose failed to recognize a familiar object when replaced by a novel object as well as to recognize a familiar juvenile rat after a short period of time. However, Mn did not alter olfactory discrimination ability. In addition, Mn-treated rats displayed decreased levels of non-protein thiols (e.g. glutathione) and increased levels of glial fibrillary acidic protein (GFAP) in the striatum. Moreover, Mn significantly increased hippocampal glutathione peroxidase (GPx) activity. These findings demonstrate that acute low-level exposure to Mn during a critical neurodevelopmental period causes cognitive and motor dysfunctions that last into adulthood, that are accompanied by alterations in antioxidant defense system in both the hippocampus and striatum. (C) 2015 Elsevier Inc. All rights reserved.
We analyzed published records of terrigenous dust flux from marine sediments off subtropical West Africa, the eastern Mediterranean Sea, and the Arabian Sea, and lake records from East Africa using statistical methods to detect trends, rhythms and events in Plio-Pleistocene African climate. The critical reassessment of the environmental significance of dust flux and lake records removes the apparent inconsistencies between marine vs. terrestrial records of African climate variability. Based on these results, major steps in mammalian and hominin evolution occurred during episodes of a wetter, but highly variable climate largely controlled by orbitally induced insolation changes in the low latitudes.
HESS J1943+213
(2018)
Archer, A. ; Benbow, Wystan ; Bird, Ralph ; Brose, Robert ; Buchovecky, M. ; Bugaev, V ; Cui, Wei ; Danie, M. K. ; Falcone, A. ; Feng, Qi ; Finley, John P. ; Flinders, A. ; Fortson, L. ; Furniss, Amy ; Gillanders, Gerard H. ; Huttens, M. ; Hanna, David ; Hervet, O. ; Holder, J. ; Hughes, G. ; Humensky, T. B. ; Johnson, Caitlin A. ; Kaaret, Philip ; Kar, P. ; Kelley-Hoskins, N. ; Kieda, David ; Krause, Maria ; Krennrich, F. ; Kumar, S. ; Lang, M. J. ; Lin, T. T. Y. ; McArthur, S. ; Moriarty, P. ; Mukherjee, Reshmi ; Nieto, Daniel ; Ong, R. A. ; Otte, A. N. ; Park, Nahee ; Petrashyk, A. ; Pohl, Martin ; Popkow, Alexis ; Pueschel, Elisa ; Quinn, J. ; Ragan, K. ; Reynold, P. T. ; Richards, Gregory T. ; Roache, E. ; Rulten, C. ; Sadeh, I ; Sembroski, G. H. ; Shahinyan, Karlen ; Tyler, J. ; Wakely, S. P. ; Weiner, O. M. ; Weinstein, A. ; Wells, R. M. ; Wilcox, P. ; Wilhelm, Alina ; Williams, David A. ; Brisken, W. F. ; Pontrelli, P.
HESS J1943+213 is a very high energy (VHE; > 100 GeV) gamma-ray source in the direction of the Galactic plane. Studies exploring the classification of the source are converging toward its identification as an extreme synchrotron BL Lac object. Here we present 38 hr of VERITAS observations of HESS J1943+213 taken over 2 yr. The source is detected with a significance of similar to 20 standard deviations, showing a remarkably stable flux and spectrum in VHE gamma-rays. Multifrequency Very Long Baseline Array (VLBA) observations of the source confirm the extended, jet-like structure previously found in the 1.6 GHz band with the European VLBI Network and detect this component in the 4.6 and 7.3 GHz bands. The radio spectral indices of the core and the jet and the level of polarization derived from the VLBA observations are in a range typical for blazars. Data from VERITAS, Fermi-LAT, Swift-XRT, the FLWO 48 ' telescope, and archival infrared and hard X-ray observations are used to construct and model the spectral energy distribution (SED) of the source with a synchrotron self-Compton model. The well-measured gamma-ray peak of the SED with VERITAS and Fermi-LAT provides constraining upper limits on the source redshift. Possible contribution of secondary gamma-rays from ultra-high-energy cosmic-ray-initiated electromagnetic cascades to the gamma-ray emission is explored, finding that only a segment of the VHE spectrum can be accommodated with this process. A variability search is performed across X-ray and gamma-ray bands. No statistically significant flux or spectral variability is detected.
Abeysekara, A. U. ; Archer, A. ; Benbow, Wystan ; Bird, Ralph ; Brill, A. ; Brose, Robert ; Buckley, J. H. ; Christiansen, Jessie L. ; Chromey, A. J. ; Daniel, M. K. ; Falcone, A. ; Feng, Qi ; Finley, John P. ; Fortson, L. ; Furniss, Amy ; Gillanders, Gerard H. ; Gueta, O. ; Hanna, David ; Hervet, O. ; Holder, J. ; Hughes, G. ; Humensky, T. B. ; Johnson, Caitlin A. ; Kaaret, Philip ; Kar, P. ; Kelley-Hoskins, N. ; Kertzman, M. ; Kieda, David ; Krause, Maria ; Krennrich, F. ; Lang, M. J. ; Moriarty, P. ; Mukherjee, Reshmi ; Ong, R. A. ; Otte, A. N. ; Park, N. ; Petrashyk, A. ; Pohl, Martin ; Pueschel, Elisa ; Quinn, J. ; Ragan, K. ; Reynolds, P. T. ; Richards, Gregory T. ; Roache, E. ; Rulten, C. ; Sadeh, I. ; Santander, Marcos ; Scott, S. S. ; Sembroski, G. H. ; Shahinyan, Karlen ; Tyler, J. ; Wakely, S. P. ; Weinstein, A. ; Wells, R. M. ; Wilcox, P. ; Wilhelm, Alina ; Williams, D. A. ; Williamson, T. J. ; Zitzer, B. ; Kaur, A.
On 2017 September 22, the IceCube Neutrino Observatory reported the detection of the high-energy neutrino event IC 170922A, of potential astrophysical origin. It was soon determined that the neutrino direction was consistent with the location of the gamma-ray blazar TXS 0506+056. (3FGL J0509.4+ 0541), which was in an elevated gamma-ray emission state as measured by the Fermi satellite. Very Energetic Radiation Imaging Telescope Array System (VERITAS) observations of the neutrino/blazar region started on 2017 September 23 in response to the neutrino alert and continued through 2018 February 6. While no significant very-high-energy (VHE; E > 100 GeV) emission was observed from the blazar by VERITAS in the two-week period immediately following the IceCube alert, TXS 0506+ 056 was detected by VERITAS with a significance of 5.8 standard deviations (sigma) in the full 35 hr data set. The average photon flux of the source during this period was (8.9 +/- 1.6). x. 10(-12) cm(-2) s(-1), or 1.6% of the Crab Nebula flux, above an energy threshold of 110 GeV, with a soft spectral index of 4.8. +/-. 1.3.
Archambault, S. ; Archer, A. ; Benbow, Wystan ; Bird, Ralph ; Bourbeau, E. ; Buchovecky, M. ; Buckley, J. H. ; Bugaev, V. ; Cerruti, M. ; Connolly, M. P. ; Cui, W. ; Dwarkadas, Vikram V. ; Errando, M. ; Falcone, A. ; Feng, Q. ; Finley, J. P. ; Fleischhack, H. ; Fortson, L. ; Furniss, A. ; Griffin, S. ; Huetten, M. ; Hanna, D. ; Holder, J. ; Johnson, C. A. ; Kaaret, P. ; Kar, P. ; Kelley-Hoskins, N. ; Kertzman, M. ; Kieda, D. ; Krause, M. ; Kumar, S. ; Lang, M. J. ; Maier, G. ; McArthur, S. ; McCann, A. ; Moriarty, P. ; Mukherjee, R. ; Nieto, D. ; Ong, R. A. ; Otte, A. N. ; Park, Nahee ; Pohl, Martin ; Popkow, A. ; Pueschel, Elisa ; Quinn, J. ; Ragan, K. ; Reynolds, P. T. ; Richards, G. T. ; Roache, E. ; Sadeh, I. ; Santander, M. ; Sembroski, G. H. ; Shahinyan, K. ; Slane, P. ; Staszak, D. ; Telezhinsky, Igor O. ; Trepanier, S. ; Tyler, J. ; Wakely, S. P. ; Weinstein, A. ; Weisgarber, T. ; Wilcox, P. ; Wilhelm, Alina ; Williams, D. A. ; Zitzer, B.
Radchuk, Viktoriia ; Reed, Thomas ; Teplitsky, Celine ; van de Pol, Martijn ; Charmantier, Anne ; Hassall, Christopher ; Adamik, Peter ; Adriaensen, Frank ; Ahola, Markus P. ; Arcese, Peter ; Miguel Aviles, Jesus ; Balbontin, Javier ; Berg, Karl S. ; Borras, Antoni ; Burthe, Sarah ; Clobert, Jean ; Dehnhard, Nina ; de Lope, Florentino ; Dhondt, Andre A. ; Dingemanse, Niels J. ; Doi, Hideyuki ; Eeva, Tapio ; Fickel, Jörns ; Filella, Iolanda ; Fossoy, Frode ; Goodenough, Anne E. ; Hall, Stephen J. G. ; Hansson, Bengt ; Harris, Michael ; Hasselquist, Dennis ; Hickler, Thomas ; Jasmin Radha, Jasmin ; Kharouba, Heather ; Gabriel Martinez, Juan ; Mihoub, Jean-Baptiste ; Mills, James A. ; Molina-Morales, Mercedes ; Moksnes, Arne ; Ozgul, Arpat ; Parejo, Deseada ; Pilard, Philippe ; Poisbleau, Maud ; Rousset, Francois ; Rödel, Mark-Oliver ; Scott, David ; Carlos Senar, Juan ; Stefanescu, Constanti ; Stokke, Bard G. ; Kusano, Tamotsu ; Tarka, Maja ; Tarwater, Corey E. ; Thonicke, Kirsten ; Thorley, Jack ; Wilting, Andreas ; Tryjanowski, Piotr ; Merila, Juha ; Sheldon, Ben C. ; Moller, Anders Pape ; Matthysen, Erik ; Janzen, Fredric ; Dobson, F. Stephen ; Visser, Marcel E. ; Beissinger, Steven R. ; Courtiol, Alexandre ; Kramer-Schadt, Stephanie
Biological responses to climate change have been widely documented across taxa and regions, but it remains unclear whether species are maintaining a good match between phenotype and environment, i.e. whether observed trait changes are adaptive. Here we reviewed 10,090 abstracts and extracted data from 71 studies reported in 58 relevant publications, to assess quantitatively whether phenotypic trait changes associated with climate change are adaptive in animals. A meta-analysis focussing on birds, the taxon best represented in our dataset, suggests that global warming has not systematically affected morphological traits, but has advanced phenological traits. We demonstrate that these advances are adaptive for some species, but imperfect as evidenced by the observed consistent selection for earlier timing. Application of a theoretical model indicates that the evolutionary load imposed by incomplete adaptive responses to ongoing climate change may already be threatening the persistence of species.
Kasmi, Sofien ; Zouhal, Hassane ; Hammami, Raouf ; Clark, Cain Craig Truman ; Hackney, Anthony C. ; Hammami, Amri ; Chtara, Moktar ; Chortane, Sabri Gaied ; Ben Salah, Fatma Zohra ; Granacher, Urs ; Ben Ounis, Omar
Background: The standard method to treat physically active patients with anterior cruciate ligament (ACL) rupture is ligament reconstruction surgery. The rehabilitation training program is very important to improve functional performance in recreational athletes following ACL reconstruction.
Objectives: The aims of this study were to compare the effects of three different training programs, eccentric training (ECC), plyometric training (PLYO), or combined eccentric and plyometric training (COMB), on dynamic balance (Y-BAL), the Lysholm Knee Scale (LKS), the return to sport index (RSI), and the leg symmetry index (LSI) for the single leg hop test for distance in elite female athletes after ACL surgery.
Materials and Methods: Fourteen weeks after rehabilitation from surgery, 40 elite female athletes (20.3 ± 3.2 years), who had undergone an ACL reconstruction, participated in a short-term (6 weeks; two times a week) training study. All participants received the same rehabilitation protocol prior to the training study. Athletes were randomly assigned to three experimental groups, ECC (n = 10), PLYO (n = 10), and COMB (n = 10), and to a control group (CON: n = 10). Testing was conducted before and after the 6-week training programs and included the Y-BAL, LKS, and RSI. LSI was assessed after the 6-week training programs only.
Results: Adherence rate was 100% across all groups and no training or test-related injuries were reported. No significant between-group baseline differences (pre-6-week training) were observed for any of the parameters. Significant group-by-time interactions were found for Y-BAL (p < 0.001, ES = 1.73), LKS (p < 0.001, ES = 0.76), and RSI (p < 0.001, ES = 1.39). Contrast analysis demonstrated that COMB yielded significantly greater improvements in Y-BAL, LKS, and RSI (all p < 0.001), in addition to significantly better performances in LSI (all p < 0.001), than CON, PLYO, and ECC, respectively.
Conclusion: In conclusion, combined (eccentric/plyometric) training seems to represent the most effective training method as it exerts positive effects on both stability and functional performance in the post-ACL-surgical rehabilitation period of elite female athletes.
Sariati, Dorsaf ; Zouhal, Hassane ; Hammami, Raouf ; Clark, Cain Craig Truman ; Nebigh, Ammar ; Chtara, Moktar ; Hackney, Anthony C. ; Souissi, Nizar ; Granacher, Urs ; Ben Ounis, Omar
Previous studies have not considered the potential influence of maturity status on the relationship between mental imagery and change of direction (CoD) speed in youth soccer. Accordingly, this cross-sectional study examined the association between mental imagery and CoD performance in young elite soccer players of different maturity status. Forty young male soccer players, aged 10-17 years, were assigned into two groups according to their predicted age at peak height velocity (PHV) (Pre-PHV; n = 20 and Post-PHV; n = 20). Participants were evaluated on soccer-specific tests of CoD with (CoDBall-15m) and without (CoD-15m) the ball. Participants completed the movement imagery questionnaire (MIQ) with the three- dimensional structure, internal visual imagery (IVI), external visual imagery (EVI), as well as kinesthetic imagery (KI). The Post-PHV players achieved significantly better results than Pre-PHV in EVI (ES = 1.58, large; p < 0.001), CoD-15m (ES = 2.09, very large; p < 0.001) and CoDBall-15m (ES = 1.60, large; p < 0.001). Correlations were significantly different between maturity groups, where, for the pre-PHV group, a negative very large correlation was observed between CoDBall-15m and KI (r = –0.73, p = 0.001). For the post-PHV group, large negative correlations were observed between CoD-15m and IVI (r = –0.55, p = 0.011), EVI (r = –062, p = 0.003), and KI (r = –0.52, p = 0.020). A large negative correlation of CoDBall-15m with EVI (r = –0.55, p = 0.012) and very large correlation with KI (r = –0.79, p = 0.001) were also observed. This study provides evidence of the theoretical and practical use for the CoD tasks stimulus with imagery. We recommend that sport psychology specialists, coaches, and athletes integrated imagery for CoD tasks in pre-pubertal soccer players to further improve CoD related performance.
Ecosystems' exposure to climate change - Modeling as support for nature conservation management
(2016)
Abeysekara, A. U. ; Archer, A. ; Aune, Taylor ; Benbow, Wystan ; Bird, Ralph ; Brose, Robert ; Buchovecky, M. ; Bugaev, V. ; Cui, Wei ; Daniel, M. K. ; Falcone, A. ; Feng, Qi ; Finley, John P. ; Fleischhack, H. ; Flinders, A. ; Fortson, L. ; Furniss, Amy ; Gotthelf, Eric V. ; Grube, J. ; Hanna, David ; Hervet, O. ; Holder, J. ; Huang, K. ; Hughes, G. ; Humensky, T. B. ; Huetten, M. ; Johnson, Caitlin A. ; Kaaret, Philip ; Kar, P. ; Kelley-Hoskins, N. ; Kertzman, M. ; Kieda, David ; Krause, Maria ; Kumar, S. ; Lang, M. J. ; Lin, T. T. Y. ; Maier, Gernot ; McArthur, S. ; Moriarty, P. ; Mukherjee, Reshmi ; Ong, R. A. ; Otte, Adam Nepomuk ; Pandel, Dirk ; Park, Nahee ; Petrashyk, A. ; Pohl, Martin ; Popkow, Alexis ; Pueschel, Elisa ; Quinn, J. ; Ragan, K. ; Reynolds, P. T. ; Richards, Gregory T. ; Roache, E. ; Rousselle, J. ; Rulten, C. ; Sadeh, I. ; Santander, M. ; Sembroski, G. H. ; Shahinyan, Karlen ; Tyler, J. ; Vassiliev, V. V. ; Wakely, S. P. ; Ward, J. E. ; Weinstein, A. ; Wells, R. M. ; Wilcox, P. ; Wilhelm, Alina ; Williams, David A. ; Zitzer, B.
We present results from deep observations toward the Cygnus region using 300 hr of very high energy (VHE)gamma-ray data taken with the VERITAS Cerenkov telescope array and over 7 yr of high-energy.-ray data taken with the Fermi satellite at an energy above 1 GeV. As the brightest region of diffuse gamma-ray emission in the northern sky, the Cygnus region provides a promising area to probe the origins of cosmic rays. We report the identification of a potential Fermi-LAT counterpart to VER J2031+415 (TeV J2032+4130) and resolve the extended VHE source VER J2019+368 into two source candidates (VER J2018+367* and VER J2020+368*) and characterize their energy spectra. The Fermi-LAT morphology of 3FGL J2021.0+4031e (the Gamma Cygni supernova remnant) was examined, and a region of enhanced emission coincident with VER J2019+407 was identified and jointly fit with the VERITAS data. By modeling 3FGL J2015.6+3709 as two sources, one located at the location of the pulsar wind nebula CTB 87 and one at the quasar QSO J2015+371, a continuous spectrum from 1 GeV to 10 TeV was extracted for VER J2016+371 (CTB 87). An additional 71 locations coincident with Fermi-LAT sources and other potential objects of interest were tested for VHE gamma-ray emission, with no emission detected and upper limits on the differential flux placed at an average of 2.3% of the Crab Nebula flux. We interpret these observations in a multiwavelength context and present the most detailed gamma-ray view of the region to date.
Drygala, Frank ; Korablev, Nikolay ; Ansorge, Hermann ; Fickel, Jörns ; Isomursu, Marja ; Elmeros, Morten ; Kowalczyk, Rafał ; Baltrunaite, Laima ; Balciauskas, Linas ; Saarma, Urmas ; Schulze, Christoph ; Borkenhagen, Peter ; Frantz, Alain C.
The extent of gene flow during the range expansion of non-native species influences the amount of genetic diversity retained in expanding populations. Here, we analyse the population genetic structure of the raccoon dog (Nyctereutes procyonoides) in north-eastern and central Europe. This invasive species is of management concern because it is highly susceptible to fox rabies and an important secondary host of the virus. We hypothesized that the large number of introduced animals and the species' dispersal capabilities led to high population connectivity and maintenance of genetic diversity throughout the invaded range. We genotyped 332 tissue samples from seven European countries using 16 microsatellite loci. Different algorithms identified three genetic clusters corresponding to Finland, Denmark and a large 'central' population that reached from introduction areas in western Russia to northern Germany. Cluster assignments provided evidence of long-distance dispersal. The results of an Approximate Bayesian Computation analysis supported a scenario of equal effective population sizes among different pre-defined populations in the large central cluster. Our results are in line with strong gene flow and secondary admixture between neighbouring demes leading to reduced genetic structuring, probably a result of its fairly rapid population expansion after introduction. The results presented here are remarkable in the sense that we identified a homogenous genetic cluster inhabiting an area stretching over more than 1500km. They are also relevant for disease management, as in the event of a significant rabies outbreak, there is a great risk of a rapid virus spread among raccoon dog populations.
Zouita, Sghaier ; Zouhal, Hassane ; Ferchichi, Habiba ; Paillard, Thierry ; Dziri, Catherine ; Hackney, Anthony C. ; Laher, Ismail ; Granacher, Urs ; Ben Moussa Zouita, Amira
Objective: We investigated the effects of combined balance and strength training on measures of balance and muscle strength in older women with a history of falls.
Methods: Twenty-seven older women aged 70.4 ± 4.1 years (age range: 65 to 75 years) were randomly allocated to either an intervention (IG, n = 12) or an active control (CG, n = 15) group. The IG completed 8 weeks combined balance and strength training program with three sessions per week including visual biofeedback using force plates. The CG received physical therapy and gait training at a rehabilitation center. Training volumes were similar between the groups. Pre and post training, tests were applied for the assessment of muscle strength (weight-bearing squat [WBS] by measuring the percentage of body mass borne by each leg at different knee flexions [0°, 30°, 60°, and 90°], sit-to-stand test [STS]), and balance. Balance tests used the modified clinical test of sensory interaction (mCTSIB) with eyes closed (EC) and opened (EO), on stable (firm) and unstable (foam) surfaces as well as spatial parameters of gait such as step width and length (cm) and walking speed (cm/s).
Results: Significant group × time interactions were found for different degrees of knee flexion during WBS (0.0001 < p < 0.013, 0.441 < d < 0.762). Post hoc tests revealed significant pre-to-post improvements for both legs and for all degrees of flexion (0.0001 < p < 0.002, 0.697 < d < 1.875) for IG compared to CG. Significant group × time interactions were found for firm EO, foam EO, firm EC, and foam EC (0.006 < p < 0.029; 0.302 < d < 0.518). Post hoc tests showed significant pre-to-post improvements for both legs and for all degrees of oscillations (0.0001 < p < 0.004, 0.753 < d < 2.097) for IG compared to CG. This study indicates that combined balance and strength training improved percentage distribution of body weight between legs at different conditions of knee flexion (0°, 30°, 60°, and 90°) and also decreased the sway oscillation on a firm surface with eyes closed, and on foam surface (with eyes opened or closed) in the IG.
Conclusion: The higher positive effects of training seen in standing balance tests, compared with dynamic tests, suggests that balance training exercises including lateral, forward, and backward exercises improved static balance to a greater extent in older women.
In Decolonizing Universalism: A Transnational Feminist Ethic zielt Serene Khader auf eine Neuausrichtung der feministischen Perspektive, welche es schafft, dekolonial und anti-imperialistisch zu sein, ohne gleichzeitig dem Universalismus komplett abzuschwören. Die Motivation hinter dieser Neuorientierung ist die Einsicht, dass der liberale moralische Universalismus oftmals kulturelle Vorherrschaft und Imperialismus verstärkt. In diesem Kommentar wollen wir (a) uns mit der Frage beschäftigen, was genau unter Geschlechtergerechtigkeit verstanden werden soll und welcher Maßstab zur Beantwortung der Frage nach Gerechtigkeit angebracht ist und (b) einige Ideen zum Unterschied zwischen idealer und nicht-idealer Theorie liefern.
Abeysekara, A. U. ; Benbow, Wystan ; Bird, Ralph ; Brantseg, T. ; Brose, Robert ; Buchovecky, M. ; Buckley, J. H. ; Bugaev, V. ; Connolly, M. P. ; Cui, Wei ; Daniel, M. K. ; Falcone, A. ; Feng, Qi ; Finley, John P. ; Fortson, L. ; Furniss, Amy ; Gillanders, Gerard H. ; Gunawardhana, Isuru ; Huetten, M. ; Hanna, David ; Hervet, O. ; Holder, J. ; Hughes, G. ; Humensky, T. B. ; Johnson, Caitlin A. ; Kaaret, Philip ; Kar, P. ; Kertzman, M. ; Krennrich, F. ; Lang, M. J. ; Lin, T. T. Y. ; McArthur, S. ; Moriarty, P. ; Mukherjee, Reshmi ; Ong, R. A. ; Otte, Adam Nepomuk ; Park, N. ; Petrashyk, A. ; Pohl, Martin ; Pueschel, Elisa ; Quinn, J. ; Ragan, K. ; Reynolds, P. T. ; Richards, Gregory T. ; Roache, E. ; Rulten, C. ; Sadeh, I. ; Santander, M. ; Sembroski, G. H. ; Shahinyan, Karlen ; Wakely, S. P. ; Weinstein, A. ; Wells, R. M. ; Wilcox, P. ; Williams, D. A. ; Zitzer, B. ; Jorstad, Svetlana G. ; Marscher, Alan P. ; Lister, Matthew L. ; Kovalev, Yuri Y. ; Pushkarev, A. B. ; Savolainen, Tuomas ; Agudo, I. ; Molina, S. N. ; Gomez, J. L. ; Larionov, Valeri M. ; Borman, G. A. ; Mokrushina, A. A. ; Tornikoski, Merja ; Lahteenmaki, A. ; Chamani, W. ; Enestam, S. ; Kiehlmann, S. ; Hovatta, Talvikki ; Smith, P. S. ; Pontrelli, P.
Combined with measurements made by very-long-baseline interferometry, the observations of fast TeV gamma-ray flares probe the structure and emission mechanism of blazar jets. However, only a handful of such flares have been detected to date, and only within the last few years have these flares been observed from lower-frequency-peaked BL. Lac objects and flat-spectrum radio quasars. We report on a fast TeV gamma-ray flare from the blazar BL. Lacertae observed by the Very Energetic Radiation Imaging Telescope Array System (VERITAS). with a rise time of similar to 2.3 hr and a decay time of similar to 36 min. The peak flux above 200 GeV is (4.2 +/- 0.6) x 10(-6) photon m(-2) s(-1) measured with a 4-minute-binned light curve, corresponding to similar to 180% of the flux that is observed from the Crab Nebula above the same energy threshold. Variability contemporaneous with the TeV gamma-ray flare was observed in GeV gamma-ray, X-ray, and optical flux, as well as in optical and radio polarization. Additionally, a possible moving emission feature with superluminal apparent velocity was identified in Very Long Baseline Array observations at 43 GHz, potentially passing the radio core of the jet around the time of the gamma-ray flare. We discuss the constraints on the size, Lorentz factor, and location of the emitting region of the flare, and the interpretations with several theoretical models that invoke relativistic plasma passing stationary shocks.
Multiwavelength observations of the AGN 1ES 0414+009 with veritas, FERMI-LAT, SWIFT-XRT, AND MDM
(2012)
Aliu, E. ; Archambault, S. ; Arlen, T. ; Aune, T. ; Beilicke, M. ; Benbow, W. ; Boettcher, Markus ; Bouvier, A. ; Bugaev, V. ; Cannon, A. ; Cesarini, A. ; Ciupik, L. ; Collins-Hughes, E. ; Connolly, M. P. ; Cui, W. ; Dickherber, R. ; Dumm, J. ; Errando, M. ; Falcone, A. ; Federici, Stefania ; Feng, Q. ; Finley, J. P. ; Finnegan, G. ; Fortson, L. ; Furniss, A. ; Galante, N. ; Gall, D. ; Godambe, S. ; Griffin, S. ; Grube, J. ; Gyuk, G. ; Hanna, D. ; Holder, J. ; Huan, H. ; Hughes, G. ; Hui, C. M. ; Imran, A. ; Jameil, O. ; Kaaret, P. ; Karlsson, N. ; Kertzman, M. ; Kerr, J. ; Khassen, Y. ; Kieda, D. ; Krawczynski, H. ; Krennrich, F. ; Lang, M. J. ; Lee, K. ; Madhavan, A. S. ; Majumdar, P. ; McArthur, S. ; McCann, A. ; Moriarty, P. ; Mukherjee, R. ; Nelson, T. ; de Bhroithe, A. O'Faolain ; Ong, R. A. ; Orr, M. ; Otte, A. N. ; Park, N. ; Perkins, J. S. ; Pichel, A. ; Pohl, Martin ; Quinn, J. ; Ragan, K. ; Reynolds, P. T. ; Roache, E. ; Ruppel, J. ; Saxon, D. B. ; Schroedter, M. ; Sembroski, G. H. ; Sentuerk, G. D. ; Smith, A. W. ; Staszak, D. ; Stroh, M. ; Telezhinsky, Igor O. ; Tesic, G. ; Theiling, M. ; Thibadeau, S. ; Tsurusaki, K. ; Varlotta, A. ; Vassiliev, V. V. ; Vivier, M. ; Wakely, S. P. ; Ward, J. E. ; Weinstein, A. ; Welsing, R. ; Williams, D. A. ; Zitzer, B.
We present observations of the BL Lac object 1ES 0414+009 in the >200 GeV gamma-ray band by the VERITAS array of Cherenkov telescopes. 1ES 0414+009 was observed by VERITAS between 2008 January and 2011 February, resulting in 56.2 hr of good quality pointed observations. These observations resulted in a detection of 822 events from the source corresponding to a statistical significance of 6.4 standard deviations (6.4 sigma) above the background. The source flux, showing no evidence for variability, is measured as (5.2 +/- 1.1(stat) +/- 2.6(sys)) x 10(-12) photons cm(-2) s(-1) above 200 GeV, equivalent to approximately 2% of the Crab Nebula flux above this energy. The differential photon spectrum from 230 GeV to 850 GeV is well fit by a power law with a photon index of Gamma = 3.4 +/- 0.5(stat) +/- 0.3(sys) and a flux normalization of (1.6 +/- 0.3(stat) +/- 0.8(sys)) x 10(-11) photons cm(-2) s(-1) at 300 GeV. We also present multiwavelength results taken in the optical (MDM), x-ray (Swift-XRT), and GeV (Fermi-LAT) bands and use these results to construct a broadband spectral energy distribution (SED). Modeling of this SED indicates that homogenous one-zone leptonic scenarios are not adequate to describe emission from the system, with a lepto-hadronic model providing a better fit to the data.
Dämpfling, Helge L. C. ; Mielke, Christian ; Koellner, Nicole ; Lorenz, Melanie ; Rogass, Christian ; Altenberger, Uwe ; Harlov, Daniel E. ; Knoper, Michael
In this study we present a novel method for the automatic detection of minerals and elements using hyperspectral transmittance imaging microscopy measurements of complete thin sections (HyperTIM).
This is accomplished by using a hyperspectral camera system that operates in the visible and near-infrared (VNIR) range with a specifically designed sample holder, scanning setup, and a microscope lens.
We utilize this method on a monazite ore thin section from Steenkampskraal (South Africa), which we analyzed for the rare earth element (REE)-bearing mineral monazite ((Ce,Nd,La)PO4), with high concentrations of Nd. The transmittance analyses with the hyperspectral VNIR camera can be used to identify REE minerals and Nd in thin sections.
We propose a three-point band depth index, the Nd feature depth index (NdFD), and its related product the Nd band depth index (NdBDI), which enables automatic mineral detection and classification for the Nd-bearing monazites in thin sections. In combination with the average concentration of the relative Nd content, it permits a destruction-free, total concentration calculation for Nd across the entire thin section.
The results of streamflow trend studies are often characterized by mostly insignificant trends and inexplicable spatial patterns. In our study region, Western Austria, this applies especially for trends of annually averaged runoff. However, analysing the altitudinal aspect, we found that there is a trend gradient from higher-altitude to lower-altitude stations, i.e. a pattern of mostly positive annual trends at higher stations and negative ones at lower stations. At midaltitudes, the trends are mostly insignificant. Here we hypothesize that the streamflow trends are caused by the following two main processes: on the one hand, melting glaciers produce excess runoff at higher-altitude watersheds. On the other hand, rising temperatures potentially alter hydrological conditions in terms of less snowfall, higher infiltration, enhanced evapotranspiration, etc., which in turn results in decreasing streamflow trends at lower-altitude watersheds. However, these patterns are masked at mid-altitudes because the resulting positive and negative trends balance each other. To support these hypotheses, we attempted to attribute the detected trends to specific causes. For this purpose, we analysed trends of filtered daily streamflow data, as the causes for these changes might be restricted to a smaller temporal scale than the annual one. This allowed for the explicit determination of the exact days of year (DOYs) when certain streamflow trends emerge, which were then linked with the corresponding DOYs of the trends and characteristic dates of other observed variables, e.g. the average DOY when temperature crosses the freezing point in spring. Based on these analyses, an empirical statistical model was derived that was able to simulate daily streamflow trends sufficiently well. Analyses of subdaily streamflow changes provided additional insights. Finally, the present study supports many modelling approaches in the literature which found out that the main drivers of alpine streamflow changes are increased glacial melt, earlier snowmelt and lower snow accumulation in wintertime.
Abeysekara, A. U. ; Archer, A. ; Benbow, Wystan ; Bird, Ralph ; Brose, Robert ; Buchovecky, M. ; Bugaev, V. ; Connolly, M. P. ; Cui, Wei ; Errando, Manel ; Falcone, A. ; Feng, Qi ; Finley, John P. ; Flinders, A. ; Fortson, L. ; Furniss, Amy ; Gillanders, Gerard H. ; Huetten, M. ; Hanna, David ; Hervet, O. ; Holder, J. ; Hughes, G. ; Humensky, T. B. ; Johnson, Caitlin A. ; Kaaret, Philip ; Kar, P. ; Kelley-Hoskins, N. ; Kertzman, M. ; Kieda, David ; Krause, Maria ; Krennrich, F. ; Lang, M. J. ; Lin, T. T. Y. ; Maier, Gernot ; McArthur, S. ; Moriarty, P. ; Mukherjee, Reshmi ; Ong, R. A. ; Park, N. ; Perkins, Jeremy S. ; Petrashyk, A. ; Pohl, Martin ; Popkow, Alexis ; Pueschel, Elisa ; Quinn, J. ; Ragan, K. ; Reynolds, P. T. ; Richards, Gregory T. ; Roache, E. ; Rulten, C. ; Sadeh, I. ; Santander, M. ; Sembroski, G. H. ; Shahinyan, Karlen ; Tyler, J. ; Wakely, S. P. ; Weiner, O. M. ; Weinstein, A. ; Wells, R. M. ; Wilcox, P. ; Wilhelm, Alina ; Williams, David A. ; Zitzer, B. ; Vurm, Indrek ; Beloborodov, Andrei
On 2015 March 23, the Very Energetic Radiation Imaging Telescope Array System (VERITAS) responded to a Swift-Burst Alert Telescope (BAT) detection of a gamma-ray burst, with observations beginning 270 s after the onset of BAT emission, and only 135 s after the main BAT emission peak. No statistically significant signal is detected above 140 GeV. The VERITAS upper limit on the fluence in a 40-minute integration corresponds to about 1% of the prompt fluence. Our limit is particularly significant because the very-high-energy (VHE) observation started only similar to 2 minutes after the prompt emission peaked, and Fermi-Large Area Telescope observations of numerous other bursts have revealed that the high-energy emission is typically delayed relative to the prompt radiation and lasts significantly longer. Also, the proximity of GRB 150323A (z = 0.593) limits the attenuation by the extragalactic background light to similar to 50% at 100-200 GeV. We conclude that GRB 150323A had an intrinsically very weak high-energy afterglow, or that the GeV spectrum had a turnover below similar to 100 GeV. If the GRB exploded into the stellar wind of a massive progenitor, the VHE non-detection constrains the wind density parameter to be A greater than or similar to 3 x 10(11) g . cm(-1), consistent with a standard Wolf-Rayet progenitor. Alternatively, the VHE emission from the blast wave would be weak in a very tenuous medium such as the interstellar medium, which therefore cannot be ruled out as the environment of GRB 150323A.
Aliu, E. ; Archambault, S. ; Aune, T. ; Behera, B. ; Beilicke, M. ; Benbow, W. ; Berger, K. ; Bird, R. ; Buckley, J. H. ; Bugaev, V. ; Cardenzana, J. V. ; Cerruti, M. ; Chen, Xuhui ; Ciupik, L. ; Collins-Hughes, E. ; Connolly, M. P. ; Cui, W. ; Dumm, J. ; Dwarkadas, Vikram V. ; Errando, M. ; Falcone, A. ; Federici, Simone ; Feng, Q. ; Finley, J. P. ; Fleischhack, H. ; Fortin, P. ; Fortson, L. ; Furniss, A. ; Galante, N. ; Gall, D. ; Gillanders, G. H. ; Griffin, S. ; Griffiths, S. T. ; Grube, J. ; Gyuk, G. ; Hanna, D. ; Holder, J. ; Hughes, G. ; Humensky, T. B. ; Kaaret, P. ; Kertzman, M. ; Khassen, Y. ; Kieda, D. ; Krennrich, F. ; Kumar, S. ; Lang, M. J. ; Madhavan, A. S. ; Maier, G. ; McCann, A. J. ; Meagher, K. ; Millis, J. ; Moriarty, P. ; Mukherjee, R. ; Nieto, D. ; Ong, R. A. ; Otte, A. N. ; Pandel, D. ; Park, N. ; Pohl, Martin ; Popkow, A. ; Prokoph, H. ; Quinn, J. ; Ragan, K. ; Rajotte, J. ; Ratliff, G. ; Reyes, L. C. ; Reynolds, P. T. ; Richards, G. T. ; Roache, E. ; Rousselle, J. ; Sembroski, G. H. ; Shahinyan, K. ; Sheidaei, F. ; Smith, A. W. ; Staszak, D. ; Telezhinsky, Igor O. ; Tsurusaki, K. ; Tucci, J. V. ; Tyler, J. ; Varlotta, A. ; Vassiliev, V. V. ; Vincent, S. ; Wakely, S. P. ; Ward, J. E. ; Weinstein, A. ; Welsing, R. ; Wilhelm, Alina
We report on deep observations of the extended TeV gamma-ray source MGRO J1908+06 made with the VERITAS very high energy gamma-ray observatory. Previously, the TeV emission has been attributed to the pulsar wind nebula (PWN) of the Fermi-LAT pulsar PSR J1907+0602. We detect MGRO J1908+06 at a significance level of 14 standard deviations (14 sigma) and measure a photon index of 2.20 +/- 0.10(stat) +/- 0.20(sys). The TeV emission is extended, covering the region near PSR J1907+0602 and also extending toward SNR G40.5-0.5. When fitted with a two-dimensional Gaussian, the intrinsic extension has a standard deviation of sigma(src) = 0 degrees.44 +/- 0 degrees.02. In contrast to other TeV PWNe of similar age in which the TeV spectrum softens with distance from the pulsar, the TeV spectrum measured near the pulsar location is consistent with that measured at a position near the rim of G40.5-0.5, 0 degrees.33 away.
Sarcopenia
(2020)
Wiedmer, Petra ; Jung, Tobias ; Castro, Jose Pedro ; Pomatto, Laura C. D. ; Sun, Patrick Y. ; Davies, Kelvin J. A. ; Grune, Tilman
Sarcopenia represents a muscle-wasting syndrome characterized by progressive and generalized degenerative loss of skeletal muscle mass, quality, and strength occurring during normal aging. Sarcopenia patients are mainly suffering from the loss in muscle strength and are faced with mobility disorders reducing their quality of life and are, therefore, at higher risk for morbidity (falls, bone fracture, metabolic diseases) and mortality. <br /> Several molecular mechanisms have been described as causes for sarcopenia that refer to very different levels of muscle physiology. These mechanisms cover e. g. function of hormones (e. g. IGF-1 and Insulin), muscle fiber composition and neuromuscular drive, myo-satellite cell potential to differentiate and proliferate, inflammatory pathways as well as intracellular mechanisms in the processes of proteostasis and mitochondrial function. <br /> In this review, we describe sarcopenia as a muscle-wasting syndrome distinct from other atrophic diseases and summarize the current view on molecular causes of sarcopenia development as well as open questions provoking further research efforts for establishing efficient lifestyle and therapeutic interventions.
Channel transmission losses in drylands take place normally in extensive alluvial channels or streambeds underlain by fractured rocks. They can play an important role in streamflow rates, groundwater recharge, freshwater supply and channel-associated ecosystems. We aim to develop a process-oriented, semi-distributed channel transmission losses model, using process formulations which are suitable for data-scarce dryland environments and applicable to both hydraulically disconnected losing streams and hydraulically connected losing(/gaining) streams. This approach should be able to cover a large variation in climate and hydro-geologic controls, which are typically found in dryland regions of the Earth. Our model was first evaluated for a losing/gaining, hydraulically connected 30 km reach of the Middle Jaguaribe River (MJR), Ceara, Brazil, which drains a catchment area of 20 000 km(2). Secondly, we applied it to a small losing, hydraulically disconnected 1.5 km channel reach in the Walnut Gulch Experimental Watershed (WGEW), Arizona, USA. The model was able to predict reliably the streamflow volume and peak for both case studies without using any parameter calibration procedure. We have shown that the evaluation of the hypotheses on the dominant hydrological processes was fundamental for reducing structural model uncertainties and improving the streamflow prediction. For instance, in the case of the large river reach (MJR), it was shown that both lateral stream-aquifer water fluxes and groundwater flow in the underlying alluvium parallel to the river course are necessary to predict streamflow volume and channel transmission losses, the former process being more relevant than the latter. Regarding model uncertainty, it was shown that the approaches, which were applied for the unsaturated zone processes (highly nonlinear with elaborate numerical solutions), are much more sensitive to parameter variability than those approaches which were used for the saturated zone (mathematically simple water budgeting in aquifer columns, including backwater effects). In case of the MJR-application, we have seen that structural uncertainties due to the limited knowledge of the subsurface saturated system interactions (i.e. groundwater coupling with channel water; possible groundwater flow parallel to the river) were more relevant than those related to the subsurface parameter variability. In case of the WEGW application we have seen that the non-linearity involved in the unsaturated flow processes in disconnected dryland river systems (controlled by the unsaturated zone) generally contain far more model uncertainties than do connected systems controlled by the saturated flow. Therefore, the degree of aridity of a dryland river may be an indicator of potential model uncertainty and subsequent attainable predictability of the system.
Drygala, Frank ; Korablev, Nikolay ; Ansorge, Hermann ; Fickel, Jörns ; Isomursu, Marja ; Elmeros, Morten ; Kowalczyk, Rafal ; Baltrunaite, Laima ; Balciauskas, Linas ; Saarma, Urmas ; Schulze, Christoph ; Borkenhagen, Peter ; Frantz, Alain C.
The extent of gene flow during the range expansion of non-native species influences the amount of genetic diversity retained in expanding populations. Here, we analyse the population genetic structure of the raccoon dog (Nyctereutes procyonoides) in north-eastern and central Europe. This invasive species is of management concern because it is highly susceptible to fox rabies and an important secondary host of the virus. We hypothesized that the large number of introduced animals and the species’ dispersal capabilities led to high population connectivity and maintenance of genetic diversity throughout the invaded range. We genotyped 332 tissue samples from seven European countries using 16 microsatellite loci. Different algorithms identified three genetic clusters corresponding to Finland, Denmark and a large ‘central’ population that reached from introduction areas in western Russia to northern Germany. Cluster assignments provided evidence of long-distance dispersal. The results of an Approximate Bayesian Computation analysis supported a scenario of equal effective population sizes among different pre-defined populations in the large central cluster. Our results are in line with strong gene flow and secondary admixture between neighbouring demes leading to reduced genetic structuring, probably a result of its fairly rapid population expansion after introduction. The results presented here are remarkable in the sense that we identified a homogenous genetic cluster inhabiting an area stretching over more than 1500km. They are also relevant for disease management, as in the event of a significant rabies outbreak, there is a great risk of a rapid virus spread among raccoon dog populations.
Arazi, Hamid ; Asadi, Abbas ; Khalkhali, Farhood ; Boullosa, Daniel ; Hackney, Anthony C. ; Granacher, Urs ; Zouhal, Hassane
This study aimed to investigate the relationship between the acute to chronic workload ratio (ACWR), based upon participant session rating of perceived exertion (sRPE), using two models [(1) rolling averages (ACWRRA); and (2) exponentially weighted moving averages (ACWREWMA)] and the injury rate in young male team soccer players aged 17.1 ± 0.7 years during a competitive mesocycle. Twenty-two players were enrolled in this study and performed four training sessions per week with 2 days of recovery and 1 match day per week. During each training session and each weekly match, training time and sRPE were recorded. In addition, training impulse (TRIMP), monotony, and strain were subsequently calculated. The rate of injury was recorded for each soccer player over a period of 4 weeks (i.e., 28 days) using a daily questionnaire. The results showed that over the course of the study, the number of non-contact injuries was significantly higher than that for contact injuries (2.5 vs. 0.5, p = 0.01). There were also significant positive correlations between sRPE and training time (r = 0.411, p = 0.039), ACWRRA (r = 0.47, p = 0.049), and ACWREWMA (r = 0.51, p = 0.038). In addition, small-to-medium correlations were detected between ACWR and non-contact injury occurrence (ACWRRA, r = 0.31, p = 0.05; ACWREWMA, r = 0.53, p = 0.03). Explained variance (r²) for non-contact injury was significantly greater using the ACWREWMA model (ranging between 21 and 52%) compared with ACWRRA (ranging between 17 and 39%). In conclusion, the results of this study showed that the ACWREWMA model is more sensitive than ACWRRA to identify non-contact injury occurrence in male team soccer players during a short period in the competitive season.
Jannasch, Franziska ; Kröger, Janine ; Agnoli, Claudia ; Barricarte, Aurelio ; Boeing, Heiner ; Cayssials, Valérie ; Colorado-Yohar, Sandra ; Dahm, Christina C. ; Dow, Courtney ; Fagherazzi, Guy ; Franks, Paul W. ; Freisling, Heinz ; Gunter, Marc J. ; Kerrison, Nicola D. ; Key, Timothy J. ; Khaw, Kay-Tee ; Kühn, Tilman ; Kyro, Cecilie ; Mancini, Francesca Romana ; Mokoroa, Olatz ; Nilsson, Peter ; Overvad, Kim ; Palli, Domenico ; Panico, Salvatore ; Quiros Garcia, Jose Ramon ; Rolandsson, Olov ; Sacerdote, Carlotta ; Sanchez, Maria-Jose ; Sahrai, Mohammad Sediq ; Schübel, Ruth ; Sluijs, Ivonne ; Spijkerman, Annemieke M. W. ; Tjonneland, Anne ; Tong, Tammy Y. N. ; Tumino, Rosario ; Riboli, Elio ; Langenberg, Claudia ; Sharp, Stephen J. ; Forouhi, Nita G. ; Schulze, Matthias Bernd ; Wareham, Nicholas J.
Background: Population-specificity of exploratory dietary patterns limits their generalizability in investigations with type 2 diabetes incidence.
Objective: The aim of this study was to derive country-specific exploratory dietary patterns, investigate their association with type 2 diabetes incidence, and replicate diabetes-associated dietary patterns in other countries.
Methods: Dietary intake data were used, assessed by country-specific questionnaires at baseline of 11,183 incident diabetes cases and 14,694 subcohort members (mean age 52.9 y) from 8 countries, nested within the European Prospective Investigation into Cancer and Nutrition study (mean follow-up time 6.9 y). Exploratory dietary patterns were derived by principal component analysis. HRs for incident type 2 diabetes were calculated by Prentice-weighted Cox proportional hazard regression models. Diabetes-associated dietary patterns were simplified or replicated to be applicable in other countries. A meta-analysis across all countries evaluated the generalizability of the diabetes-association.
Results: Two dietary patterns per country/UK-center, of which overall 3 dietary patterns were diabetes-associated, were identified. A risk-lowering French dietary pattern was not confirmed across other countries: pooled HRFrance per 1 SD: 1.00; 95% CI: 0.90, 1.10. Risk-increasing dietary patterns, derived in Spain and UK-Norfolk, were confirmed, but only the latter statistically significantly: HRSpain: 1.09; 95% CI: 0.97, 1.22 and HRUK-Norfolk: 1.12; 95% CI: 1.04, 1.20. Respectively, this dietary pattern was characterized by relatively high intakes of potatoes, processed meat, vegetable oils, sugar, cake and cookies, and tea. Conclusions: Only few country/center-specific dietary patterns (3 of 18) were statistically significantly associated with diabetes incidence in this multicountry European study population. One pattern, whose association with diabetes was confirmed across other countries, showed overlaps in the food groups potatoes and processed meat with identified diabetes-associated dietary patterns from other studies. The study demonstrates that replication of associations of exploratory patterns with health outcomes is feasible and a necessary step to overcome population-specificity in associations from such analyses.
Ahmadi, Hamid ; Herat, Nehara ; Alizadeh, Shahab ; Button, Duane C. ; Granacher, Urs ; Behm, David G.
Purpose
The objective of the investigation was to determine the concomitant effects of upper arm blood flow restriction (BFR) and inversion on elbow flexors neuromuscular responses.
Methods
Randomly allocated, 13 volunteers performed four conditions in a within-subject design: rest (control, 1-min upright position without BFR), control (1-min upright with BFR), 1-min inverted (without BFR), and 1-min inverted with BFR. Evoked and voluntary contractile properties, before, during and after a 30-s maximum voluntary contraction (MVC) exercise intervention were examined as well as pain scale.
Results
Inversion induced significant pre-exercise intervention decreases in elbow flexors MVC (21.1%, Z2p = 0.48, p = 0.02) and resting evoked twitch forces (29.4%, Z2p = 0.34, p = 0.03). The 30-s MVC induced significantly greater pre- to post-test decreases in potentiated twitch force (Z2p = 0.61, p = 0.0009) during inversion (75%) than upright (65.3%) conditions. Overall, BFR decreased MVC force 4.8% (Z2p = 0.37, p = 0.05). For upright position, BFR induced 21.0% reductions in M-wave amplitude (Z2p = 0.44, p = 0.04). There were no significant differences for electromyographic activity or voluntary activation as measured with the interpolated twitch technique. For all conditions, there was a significant increase in pain scale between the 40-60 s intervals and post-30-s MVC (upright< inversion, and without BFR< BFR).
Conclusion
The concomitant application of inversion with elbow flexors BFR only amplified neuromuscular performance impairments to a small degree. Individuals who execute forceful contractions when inverted or with BFR should be cognizant that force output may be impaired.
Abeysekara, A. U. ; Archambault, S. ; Archer, A. ; Benbow, W. ; Bird, R. ; Buchovecky, M. ; Buckley, J. H. ; Byrum, K. ; Cardenzana, J. V. ; Cerruti, M. ; Chen, Xuhui ; Christiansen, J. L. ; Ciupik, L. ; Cui, W. ; Dickinson, H. J. ; Eisch, J. D. ; Errando, M. ; Falcone, A. ; Fegan, D. J. ; Feng, Q. ; Finley, J. P. ; Fleischhack, H. ; Fortin, P. ; Fortson, L. ; Furniss, A. ; Gillanders, G. H. ; Griffin, S. ; Grube, J. ; Gyuk, G. ; Huetten, M. ; Hakansson, Nils ; Hanna, D. ; Holder, J. ; Humensky, T. B. ; Johnson, C. A. ; Kaaret, P. ; Kar, P. ; Kelley-Hoskins, N. ; Kertzman, M. ; Kieda, D. ; Krause, M. ; Krennrich, F. ; Kumar, S. ; Lang, M. J. ; Lin, T. T. Y. ; Maier, G. ; McArthur, S. ; McCann, A. ; Meagher, K. ; Moriarty, P. ; Mukherjee, R. ; Nieto, D. ; Ong, R. A. ; Otte, A. N. ; Park, N. ; Perkins, J. S. ; Petrashyk, A. ; Pohl, Martin ; Popkow, A. ; Pueschel, Elisa ; Quinn, J. ; Ragan, K. ; Ratliff, G. ; Reynolds, P. T. ; Richards, G. T. ; Roache, E. ; Santander, M. ; Sembroski, G. H. ; Shahinyan, K. ; Staszak, D. ; Telezhinsky, Igor O. ; Tucci, J. V. ; Tyler, J. ; Vincent, S. ; Wakely, S. P. ; Weiner, O. M. ; Weinstein, A. ; Williams, D. A. ; Zitzer, B.
The F-type star KIC. 8462852 has recently been identified as an exceptional target for search for extraterrestrial intelligence (SETI) observations. We describe an analysis methodology for optical SETI, which we have used to analyze nine hours of serendipitous archival observations of KIC. 8462852 made with the VERITAS gamma-ray observatory between 2009 and 2015. No evidence of pulsed optical beacons, above a pulse intensity at the Earth of approximately 1 photon m(-2), is found. We also discuss the potential use of imaging atmospheric Cherenkov telescope arrays in searching for extremely short duration optical transients in general.
Christakoudi, Sofia ; Pagoni, Panagiota ; Ferrari, Pietro ; Cross, Amanda J. ; Tzoulaki, Ioanna ; Muller, David C. ; Weiderpass, Elisabete ; Freisling, Heinz ; Murphy, Neil ; Dossus, Laure ; Turzanski Fortner, Renee ; Agudo, Antonio ; Overvad, Kim ; Perez-Cornago, Aurora ; Key, Timothy J. ; Brennan, Paul ; Johansson, Mattias ; Tjonneland, Anne ; Halkjaer, Jytte ; Boutron-Ruault, Marie-Christine ; Artaud, Fanny ; Severi, Gianluca ; Kaaks, Rudolf ; Schulze, Matthias Bernd ; Bergmann, Manuela M. ; Masala, Giovanna ; Grioni, Sara ; Simeon, Vittorio ; Tumino, Rosario ; Sacerdote, Carlotta ; Skeie, Guri ; Rylander, Charlotta ; Borch, Kristin Benjaminsen ; Quiros, J. Ramon ; Rodriguez-Barranco, Miguel ; Chirlaque, Maria-Dolores ; Ardanaz, Eva ; Amiano, Pilar ; Drake, Isabel ; Stocks, Tanja ; Häggström, Christel ; Harlid, Sophia ; Ellingjord-Dale, Merete ; Riboli, Elio ; Tsilidis, Konstantinos K.
Obesity is a risk factor for several major cancers. Associations of weight change in middle adulthood with cancer risk, however, are less clear. We examined the association of change in weight and body mass index (BMI) category during middle adulthood with 42 cancers, using multivariable Cox proportional hazards models in the European Prospective Investigation into Cancer and Nutrition cohort. Of 241 323 participants (31% men), 20% lost and 32% gained weight (>0.4 to 5.0 kg/year) during 6.9 years (average). During 8.0 years of follow-up after the second weight assessment, 20 960 incident cancers were ascertained. Independent of baseline BMI, weight gain (per one kg/year increment) was positively associated with cancer of the corpus uteri (hazard ratio [HR] = 1.14; 95% confidence interval: 1.05-1.23). Compared to stable weight (+/- 0.4 kg/year), weight gain (>0.4 to 5.0 kg/year) was positively associated with cancers of the gallbladder and bile ducts (HR = 1.41; 1.01-1.96), postmenopausal breast (HR = 1.08; 1.00-1.16) and thyroid (HR = 1.40; 1.04-1.90). Compared to maintaining normal weight, maintaining overweight or obese BMI (World Health Organisation categories) was positively associated with most obesity-related cancers. Compared to maintaining the baseline BMI category, weight gain to a higher BMI category was positively associated with cancers of the postmenopausal breast (HR = 1.19; 1.06-1.33), ovary (HR = 1.40; 1.04-1.91), corpus uteri (HR = 1.42; 1.06-1.91), kidney (HR = 1.80; 1.20-2.68) and pancreas in men (HR = 1.81; 1.11-2.95). Losing weight to a lower BMI category, however, was inversely associated with cancers of the corpus uteri (HR = 0.40; 0.23-0.69) and colon (HR = 0.69; 0.52-0.92). Our findings support avoiding weight gain and encouraging weight loss in middle adulthood.
Meyer, Dominique M.-A. ; Velazquez, Pablo F. ; Petruk, Oleh ; Chiotellis, Alexandros ; Pohl, Martin ; Camps-Farina, Artemi ; Petrov, Miroslav ; Reynoso, Estela M. ; Toledo-Roy, Juan C. ; Schneiter, E. Matias ; Castellanos-Ramirez, Antonio ; Esquivel, Alejandro
Core-collapse supernova remnants are the gaseous nebulae of galactic interstellar media (ISM) formed after the explosive death of massive stars. Their morphology and emission properties depend both on the surrounding circumstellar structure shaped by the stellar wind-ISM interaction of the progenitor star and on the local conditions of the ambient medium. In the warm phase of the Galactic plane (n approximate to 1 cm(-3), T approximate to 8000 K), an organized magnetic field of strength 7 mu G has profound consequences on the morphology of the wind bubble of massive stars at rest. In this paper, we show through 2.5D magnetohydrodynamical simulations, in the context of a Wolf-Rayet-evolving 35 M 0 star, that it affects the development of its supernova remnant. When the supernova remnant reaches its middle age (15-20 kyr), it adopts a tubular shape that results from the interaction between the isotropic supernova ejecta and the anisotropic, magnetized, shocked stellar progenitor bubble into which the supernova blast wave expands. Our calculations for non-thermal emission, i.e. radio synchrotron and inverse-Compton radiation, reveal that such supernova remnants can, due to projection effects, appear as rectangular objects in certain cases. This mechanism for shaping a supernova remnant is similar to the bipolar and elliptical planetary nebula production by wind-wind interaction in the low-mass regime of stellar evolution. If such a rectangular core-collapse supernova remnant is created, the progenitor star must not have been a runaway star. We propose that such a mechanism is at work in the shaping of the asymmetric core-collapse supernova remnant Puppis A.
Eschenlohr, Andrea ; Battiato, Marco ; Maldonado, R. ; Pontius, N. ; Kachel, T. ; Holldack, K. ; Mitzner, Rolf ; Föhlisch, Alexander ; Oppeneer, P. M. ; Stamm, C.
Irradiating a ferromagnet with a femtosecond laser pulse is known to induce an ultrafast demagnetization within a few hundred femtoseconds. Here we demonstrate that direct laser irradiation is in fact not essential for ultrafast demagnetization, and that electron cascades caused by hot electron currents accomplish it very efficiently. We optically excite a Au/Ni layered structure in which the 30 nm Au capping layer absorbs the incident laser pump pulse and subsequently use the X-ray magnetic circular dichroism technique to probe the femtosecond demagnetization of the adjacent 15 nm Ni layer. A demagnetization effect corresponding to the scenario in which the laser directly excites the Ni film is observed, but with a slight temporal delay. We explain this unexpected observation by means of the demagnetizing effect of a superdiffusive current of non-equilibrium, non-spin-polarized electrons generated in the Au layer.
Christakoudi, Sofia ; Pagoni, Panagiota ; Ferrari, Pietro ; Cross, Amanda J. ; Tzoulaki, Ioanna ; Muller, David C. ; Weiderpass, Elisabete ; Freisling, Heinz ; Murphy, Neil ; Dossus, Laure ; Turzanski Fortner, Renee ; Agudo, Antonio ; Overvad, Kim ; Perez-Cornago, Aurora ; Key, Timothy J. ; Brennan, Paul ; Johansson, Mattias ; Tjonneland, Anne ; Halkjaer, Jytte ; Boutron-Ruault, Marie-Christine ; Artaud, Fanny ; Severi, Gianluca ; Kaaks, Rudolf ; Schulze, Matthias Bernd ; Bergmann, Manuela M. ; Masala, Giovanna ; Grioni, Sara ; Simeon, Vittorio ; Tumino, Rosario ; Sacerdote, Carlotta ; Skeie, Guri ; Rylander, Charlotta ; Borch, Kristin Benjaminsen ; Quiros, J. Ramon ; Rodriguez-Barranco, Miguel ; Chirlaque, Maria-Dolores ; Ardanaz, Eva ; Amiano, Pilar ; Drake, Isabel ; Stocks, Tanja ; Haggstrom, Christel ; Harlid, Sophia ; Ellingjord-Dale, Merete ; Riboli, Elio ; Tsilidis, Konstantinos K.
Obesity is a risk factor for several major cancers. Associations of weight change in middle adulthood with cancer risk, however, are less clear. We examined the association of change in weight and body mass index (BMI) category during middle adulthood with 42 cancers, using multivariable Cox proportional hazards models in the European Prospective Investigation into Cancer and Nutrition cohort. Of 241 323 participants (31% men), 20% lost and 32% gained weight (>0.4 to 5.0 kg/year) during 6.9 years (average). During 8.0 years of follow-up after the second weight assessment, 20 960 incident cancers were ascertained. Independent of baseline BMI, weight gain (per one kg/year increment) was positively associated with cancer of the corpus uteri (hazard ratio [HR] = 1.14; 95% confidence interval: 1.05-1.23). Compared to stable weight (+/- 0.4 kg/year), weight gain (>0.4 to 5.0 kg/year) was positively associated with cancers of the gallbladder and bile ducts (HR = 1.41; 1.01-1.96), postmenopausal breast (HR = 1.08; 1.00-1.16) and thyroid (HR = 1.40; 1.04-1.90). Compared to maintaining normal weight, maintaining overweight or obese BMI (World Health Organisation categories) was positively associated with most obesity-related cancers. Compared to maintaining the baseline BMI category, weight gain to a higher BMI category was positively associated with cancers of the postmenopausal breast (HR = 1.19; 1.06-1.33), ovary (HR = 1.40; 1.04-1.91), corpus uteri (HR = 1.42; 1.06-1.91), kidney (HR = 1.80; 1.20-2.68) and pancreas in men (HR = 1.81; 1.11-2.95). Losing weight to a lower BMI category, however, was inversely associated with cancers of the corpus uteri (HR = 0.40; 0.23-0.69) and colon (HR = 0.69; 0.52-0.92). Our findings support avoiding weight gain and encouraging weight loss in middle adulthood.
Hintergrund: Kraft und Schnelligkeit stellen bedeutsame leistungsdeterminierende Faktoren im Fußball dar. Durch Komplextraining (Kombination aus Kraft- und plyometrischen Übungen in einer Trainingseinheit) lassen sich Kraft- und Schnelligkeitswerte von Athleten steigern. Unklar ist jedoch, ob ein Komplextraining (KT) gegenüber einem herkömmlichen blockweisen Krafttraining (BT) zu größeren sportmotorischen Leistungssteigerungen führt. Das Ziel der Studie war es, die Effekte von KT versus BT auf Variablen der Kraft, Schnelligkeit und Gewandtheit von Nachwuchsleistungsfußballern zu untersuchen.
Methode: Zusätzlich zum regulären Fußballtraining (ca. 6 × pro Woche, je 60 – 90 min.) führten 18 männliche Nachwuchsleistungsfußballer über sechs Wochen (2 × pro Woche, je 30 min.) entweder ein progressives KT (n = 10, Alter: 18,5 ± 2,2 Jahre) oder BT (n = 8, Alter: 18,1 ± 1,6 Jahre) durch. Vor und nach dem Training wurden Tests zur Erfassung der Kraft (Einer-Wiederholungs-Maximum [EWM] Kniebeuge), der Sprungkraft (Hockstrecksprung [HSS]), der Schnelligkeit (30-m-Sprint) und der Gewandtheit (T-Test) durchgeführt. Es wurden parameterfreie Verfahren zur Bestimmung von Unterschieden innerhalb (Wilcoxon-Test) und zwischen (Mann-Whitney-U-Test) den beiden Gruppen gerechnet.
Ergebnisse: Sowohl KT als auch BT sind sichere (keine trainings- aber sechs spielbedingte Verletzungen) und geeignete (Trainingsteilnahme in KT und BT: ≥ 80 %) Trainingsmaßnahmen in Ergänzung zum regulären Fußballtraining. Die statistische Analyse ergab signifikante Verbesserungen vom Prä- zum Posttest für die KT-Gruppe im EWM (p = 0,043) und im HSS (p = 0,046) sowie für die BT-Gruppe in der Sprintzeit über 5 m (p = 0,039) und 10 m (p = 0,026). Zudem zeigten sich für beide Gruppen signifikante Verbesserungen im T-Test (KT: p = 0,046; BT: p = 0,027). Der Gruppenvergleich (KT vs. BT) über die Zeit (Post- minus Prätest) offenbarte keine bedeutsamen Unterschiede.
Schlussfolgerung: Sowohl sechswöchiges KT als auch BT führten zu signifikanten Verbesserungen sportmotorischer Leistungen bei Nachwuchsleistungsfußballern. Allerdings konnten keine zusätzlich leistungssteigernden Effekte von KT im Vergleich zu BT ermittelt werden. In zukünftigen Studien sollte geprüft werden, ob die beobachteten testspezifischen Veränderungen, d. h. Verbesserung der Kraft/Sprungkraft in der KT-Gruppe und Verbesserung der Schnelligkeit in der BT-Gruppe der gewählten Übungsanordnung geschuldet sind oder einen generellen Effekt darstellen.
Background: Muscle strength and speed are important determinants of soccer performance. It has previously been shown that complex training (CT, combination of strength and plyometric exercises within a single training session) is effective to enhance strength and speed performance in athletes. However, it is unresolved whether CT is more effective than conventional strength training that is delivered in one single block (BT) to increase proxies of athletic performance. Thus, the aim of the present study was to investigate the effects of CT versus BT on measures of muscle strength/power, speed, and agility in elite youth soccer players. Methods: Eighteen male elite youth soccer players conducted six weeks (2 sessions/week, 30 min, each) of progressive CT (n = 10, age: 18,5 +/- 2.2 years) or BT (n=8, age: 18.1 +/- 1.6 years) in addition to their regular soccer training (approx. 6 sessions/week, 60-90 min, each). Before and after training, tests were conducted for the assessment of strength (one -repetition maximum [1RM] squat), power (countermovement jump [CMJ]), speed (30-m linear sprint), and agility (T test). Non-parametric analyses were used to calculate differences within (Wilcoxon test) and between (Mann-Whitney-U test) groups. Results: Both CT and BT proved to be safe (i.e. no training-related, but six match -related injuries reported) and feasible (i.e. attendance rate of 80% in both groups) training regimens when implemented in addition to regular soccer training. The statistical analysis revealed significant improvements from pre-training to post-training tests for the CT group in 1 RM squat (p =0.043) and CMJ height (p =0,046). For the BT -group, significantly enhanced sprint times were observed over 5 m (p = 0.039) and 10 m (p = 0.026), Furthermore, both groups significantly improved their t test time (CT: p =0.046; BT: p =0.027). However, group comparisons (CT vs. BT) over time (post-training minus pre-training test) did not show any significant differences. Conclusion: Six weeks of CT and BT resulted in significant improvements in proxies of athletic performance. Yet CT did not produce any additional effects compared to BT. Future research is needed to examine whether the observed test-specific changes, i.e. improvements in strength/power for the CT-group and improvements in speed for the BT-group, are due to the applied configuration of strength, plyometric, and sprint exercises or if they rather indicate a general training response.
Do cities represent sources, sinks or isolated islands for urban wild boar population structure?
(2017)
Stillfried, Milena ; Fickel, Jörns ; Börner, Konstantin ; Wittstatt, Ulrich ; Heddergott, Mike ; Ortmann, Sylvia ; Kramer-Schadt, Stephanie ; Frantz, Alain C.
Cesca, Simone ; Grigoli, Francesco ; Heimann, Sebastian ; Dahm, Torsten ; Kriegerowski, Marius ; Sobiesiak, M. ; Tassara, C. ; Olcay, M.
The 2014 April 1, M-w 8.1 Iquique (Chile) earthquake struck in the Northern Chile seismic gap. With a rupture length of less than 200 km, it left unbroken large segments of the former gap. Early studies were able to model the main rupture features but results are ambiguous with respect to the role of aseismic slip and left open questions on the remaining hazard at the Northern Chile gap. A striking observation of the 2014 earthquake has been its extensive preparation phase, with more than 1300 events with magnitude above M-L 3, occurring during the 15 months preceding the main shock. Increasing seismicity rates and observed peak magnitudes accompanied the last three weeks before the main shock. Thanks to the large data sets of regional recordings, we assess the precursor activity, compare foreshocks and aftershocks and model rupture preparation and rupture effects. To tackle inversion challenges for moderate events with an asymmetric network geometry, we use full waveforms techniques to locate events, map the seismicity rate and derive source parameters, obtaining moment tensors for more than 300 events (magnitudes M-w 4.0-8.1) in the period 2013 January 1-2014 April 30. This unique data set of fore- and aftershocks is investigated to distinguish rupture process models and models of strain and stress rotation during an earthquake. Results indicate that the spatial distributions of foreshocks delineated the shallower part of the rupture areas of the main shock and its largest aftershock, well matching the spatial extension of the aftershocks cloud. Most moment tensors correspond to almost pure double couple thrust mechanisms, consistent with the slab orientation. Whereas no significant differences are observed among thrust mechanisms in different areas, nor among thrust foreshocks and aftershocks, the early aftershock sequence is characterized by the presence of normal fault mechanisms, striking parallel to the trench but dipping westward. These events likely occurred in the shallow wedge structure close to the slab interface and are consequence of the increased extensional stress in this region after the largest events. The overall stress inversion result suggests a minor stress rotation after the main shock, but a significant release of the deviatoric stress. The temporal change in the distribution of focal mechanisms can also be explained in terms of the spatial heterogeneity of the stress field: under such interpretation, the potential of a large megathrust earthquake breaking a larger segment offshore Northern Chile remains high.
McCool, Weston C. ; Codding, Brian F. ; Vernon, Kenneth B. ; Wilson, Kurt M. ; Yaworsky, Peter M. ; Marwan, Norbert ; Kennett, Douglas J.
Understanding the influence of climate change and population pressure on human conflict remains a critically important topic in the social sciences. Long-term records that evaluate these dynamics across multiple centuries and outside the range of modern climatic variation are especially capable of elucidating the relative effect of-and the interaction between-climate and demography. This is crucial given that climate change may structure population growth and carrying capacity, while both climate and population influence per capita resource availability. This study couples paleoclimatic and demographic data with osteological evaluations of lethal trauma from 149 directly accelerator mass spectrometry C-14-dated individuals from the Nasca highland region of Peru. Multiple local and supraregional precipitation proxies are combined with a summed probability distribution of 149 C-14 dates to estimate population dynamics during a 700-y study window. Counter to previous findings, our analysis reveals a precipitous increase in violent deaths associated with a period of productive and stable climate, but volatile population dynamics. We conclude that favorable local climate conditions fostered population growth that put pressure on the marginal and highly circumscribed resource base, resulting in violent resource competition that manifested in over 450 y of internecine warfare. These findings help support a general theory of intergroup violence, indicating that relative resource scarcity-whether driven by reduced resource abundance or increased competition-can lead to violence in subsistence societies when the outcome is lower per capita resource availability.
Khudair, Mohammed ; Marcuzzi, Anna ; Ng, Kwok ; Tempest, Gavin Daniel ; Bartoš, František ; Peric, Ratko ; Maier, Maximilian ; Beccia, Flavia ; Boccia, Stefania ; Brandes, Mirko ; Cardon, Greet ; Carlin, Angela ; Castagna, Carolina ; Chaabene, Helmi ; Chalkley, Anna ; Ciaccioni, Simone ; Cieślińska-Świder, Joanna ; Čingienė, Vilma ; Cortis, Cristina ; Corvino, Chiara ; de Geus, Eco J. C. ; Di Baldassarre, Angela ; Di Credico, Andrea ; Drid, Patrik ; Tarazaga, Rosa Ma Fernández ; Gallè, Francesca ; Sánchez, Esther Garcia ; Gebremariam, Mekdes ; Ghinassi, Barbara ; Goudas, Marios ; Hayes, Grainne ; Honorio, Samuel ; Izzicupo, Pascal ; Jahre, Henriette ; Jelsma, Judith ; Juric, Petra ; Kolovelonis, Athanasios ; Kongsvold, Atle ; Kouidi, Evangelia ; Mansergh, Fiona ; Masanovic, Bojan ; Mekonnen, Teferi ; Mork, Paul Jarle ; Murphy, Marie ; O'Hara, Kelly ; Torun, Ayse Ozbil ; Palumbo, Federico ; Popovic, Stevo ; Prieske, Olaf ; Puharic, Zrinka ; Ribeiro, José Carlos ; Rumbold, Penny Louise Sheena ; Sandu, Petru ; Soric, Maroje ; Stavnsbo, Mette ; Syrmpas, Ioannis ; van der Ploeg, Hidde P. ; Van Hoye, Aurélie ; Vilela, Sofia ; Woods, Catherine ; Wunsch, Kathrin ; Caprinica, Laura ; MacDonncha, Ciaran ; Ling, Fiona Chun Man
Introduction Physical activity among children and adolescents remains insufficient, despite the substantial efforts made by researchers and policymakers. Identifying and furthering our understanding of potential modifiable determinants of physical activity behaviour (PAB) and sedentary behaviour (SB) is crucial for the development of interventions that promote a shift from SB to PAB. The current protocol details the process through which a series of systematic literature reviews and meta-analyses (MAs) will be conducted to produce a best-evidence statement (BESt) and inform policymakers. The overall aim is to identify modifiable determinants that are associated with changes in PAB and SB in children and adolescents (aged 5-19 years) and to quantify their effect on, or association with, PAB/SB. Methods and analysis A search will be performed in MEDLINE, SportDiscus, Web of Science, PsychINFO and Cochrane Central Register of Controlled Trials. Randomised controlled trials (RCTs) and controlled trials (CTs) that investigate the effect of interventions on PAB/SB and longitudinal studies that investigate the associations between modifiable determinants and PAB/SB at multiple time points will be sought. Risk of bias assessments will be performed using adapted versions of Cochrane's RoB V.2.0 and ROBINS-I tools for RCTs and CTs, respectively, and an adapted version of the National Institute of Health's tool for longitudinal studies. Data will be synthesised narratively and, where possible, MAs will be performed using frequentist and Bayesian statistics. Modifiable determinants will be discussed considering the settings in which they were investigated and the PAB/SB measurement methods used. Ethics and dissemination No ethical approval is needed as no primary data will be collected. The findings will be disseminated in peer-reviewed publications and academic conferences where possible. The BESt will also be shared with policy makers within the DE-PASS consortium in the first instance. Systematic review registration CRD42021282874.
Behm, David George ; Young, James D. ; Whitten, Joseph H. D. ; Reid, Jonathan C. ; Quigley, Patrick J. ; Low, Jonathan ; Li, Yimeng ; Lima, Camila D. ; Hodgson, Daniel D. ; Chaouachi, Anis ; Prieske, Olaf ; Granacher, Urs
Numerous national associations and multiple reviews have documented the safety and efficacy of strength training for children and adolescents. The literature highlights the significant training-induced increases in strength associated with youth strength training. However, the effectiveness of youth strength training programs to improve power measures is not as clear. This discrepancy may be related to training and testing specificity. Most prior youth strength training programs emphasized lower intensity resistance with relatively slow movements. Since power activities typically involve higher intensity, explosive-like contractions with higher angular velocities (e.g., plyometrics), there is a conflict between the training medium and testing measures. This meta-analysis compared strength (e.g., training with resistance or body mass) and power training programs (e.g., plyometric training) on proxies of muscle strength, power, and speed. A systematic literature search using a Boolean Search Strategy was conducted in the electronic databases PubMed, SPORT Discus, Web of Science, and Google Scholar and revealed 652 hits. After perusal of title, abstract, and full text, 107 studies were eligible for inclusion in this systematic review and meta-analysis. The meta-analysis showed small to moderate magnitude changes for training specificity with jump measures. In other words, power training was more effective than strength training for improving youth jump height. For sprint measures, strength training was more effective than power training with youth. Furthermore, strength training exhibited consistently large magnitude changes to lower body strength measures, which contrasted with the generally trivial, small and moderate magnitude training improvements of power training upon lower body strength, sprint and jump measures, respectively. Maturity related inadequacies in eccentric strength and balance might influence the lack of training specificity with the unilateral landings and propulsions associated with sprinting. Based on this meta-analysis, strength training should be incorporated prior to power training in order to establish an adequate foundation of strength for power training activities.
Werfelli, Hanen ; Hammami, Raouf ; Selmi, Mohamed Amine ; Selmi, Walid ; Gabrilo, Goran ; Clark, Cain C. T. ; Duncan, Michael ; Sekulic, Damir ; Granacher, Urs ; Rebai, Haithem
Background: High-intensity muscle actions have the potential to temporarily improve the performance which has been denoted as postactivation performance enhancement.
Objectives: This study determined the acute effects of different stretch-shortening (fast vs. low) and strength (dynamic vs. isometric) exercises executed during one training session on subsequent balance performance in youth weightlifters.
Materials and Methods: Sixteen male and female young weightlifters, aged 11.3±0.6years, performed four strength exercise conditions in randomized order, including dynamic strength (DYN; 3 sets of 3 repetitions of 10 RM) and isometric strength exercises (ISOM; 3 sets of maintaining 3s of 10 RM of back-squat), as well as fast (FSSC; 3 sets of 3 repetitions of 20-cm drop-jumps) and slow (SSSC; 3 sets of 3 hurdle jumps over a 20-cm obstacle) stretch-shortening cycle protocols. Balance performance was tested before and after each of the four exercise conditions in bipedal stance on an unstable surface (i.e., BOSU ball with flat side facing up) using two dependent variables, i.e., center of pressure surface area (CoP SA) and velocity (CoP V).
Results: There was a significant effect of time on CoP SA and CoP V [F(1,60)=54.37, d=1.88, p<0.0001; F(1,60)=9.07, d=0.77, p=0.003]. In addition, a statistically significant effect of condition on CoP SA and CoP V [F(3,60)=11.81, d=1.53, p<0.0001; F(3,60)=7.36, d=1.21, p=0.0003] was observed. Statistically significant condition-by-time interactions were found for the balance parameters CoP SA (p<0.003, d=0.54) and CoP V (p<0.002, d=0.70). Specific to contrast analysis, all specified hypotheses were tested and demonstrated that FSSC yielded significantly greater improvements than all other conditions in CoP SA and CoP V [p<0.0001 (d=1.55); p=0.0004 (d=1.19), respectively]. In addition, FSSC yielded significantly greater improvements compared with the two conditions for both balance parameters [p<0.0001 (d=2.03); p<0.0001 (d=1.45)].
Conclusion: Fast stretch-shortening cycle exercises appear to be more effective to improve short-term balance performance in young weightlifters. Due to the importance of balance for overall competitive achievement in weightlifting, it is recommended that young weightlifters implement dynamic plyometric exercises in the fast stretch-shortening cycle during the warm-up to improve their balance performance.
Sariati, Dorsaf ; Hammami, Raouf ; Zouhal, Hassane ; Clark, Cain Craig Truman ; Nebigh, Ammar ; Chtara, Moktar ; Chortane, Sabri Gaied ; Hackney, Anthony C. ; Souissi, Nizar ; Granacher, Urs ; Ben Ounis, Omar
Background: Change-of-direction (CoD) is a necessary physical ability of a field sport and may vary in youth players according to their maturation status.
Objectives: The aim of this study is: to compare the effectiveness of a 6-week CoD training intervention on dynamic balance (CS-YBT), horizontal jump (5JT), speed (10 and 30-m linear sprint times), CoD with (15 m-CoD + B) and without (15 m-CoD) the ball, in youth male soccer players at different levels of maturity [pre- and post-peak height velocity (PHV)].
Materials and Methods: Thirty elite male youth soccer players aged 10–17 years from the Tunisian first division participated in this study. The players were divided into pre- (G1, n = 15) and post-PHV (G2, n = 15) groups. Both groups completed a similar 6-week training program with two sessions per week of four CoD exercises. All players completed the following tests before and after intervention: CS-YBT; 5 JT; 10, 30, and 15 m-CoD; and 15 m-CoD + B, and data were analyzed using ANCOVA.
Results: All 30 players completed the study according to the study design and methodology. Adherence rate was 100% across all groups, and no training or test-related injuries were reported. Pre-PHV and post-PHV groups showed significant amelioration post-intervention for all dependent variables (after test > before test; p < 0.01, d = 0.09–1.51). ANOVA revealed a significant group × time interaction only for CS-YBT (F = 4.45; p < 0.04; η2 = 0.14), 5JT (F = 6.39; p < 0.02; η2 = 0.18), and 15 m-CoD (F = 7.88; p < 0.01; η2 = 0.22). CS-YBT, 5JT, and 15 m-CoD improved significantly in the post-PHV group (+ 4.56%, effect size = 1.51; + 4.51%, effect size = 1.05; and -3.08%, effect size = 0.51, respectively), more than the pre-PHV group (+ 2.77%, effect size = 0.85; + 2.91%, effect size = 0.54; and -1.56%, effect size = 0.20, respectively).
Conclusion: The CoD training program improved balance, horizontal jump, and CoD without the ball in male preadolescent and adolescent soccer players, and this improvement was greater in the post-PHV players. The maturity status of the athletes should be considered when programming CoD training for soccer players.
Werfelli, Hanen ; Hammami, Raouf ; Selmi, Mohamed Amine ; Selmi, Walid ; Gabrilo, Goran ; Clark, Cain C. T. ; Duncan, Michael ; Sekulic, Damir ; Granacher, Urs ; Rebai, Haithem
Background: High-intensity muscle actions have the potential to temporarily improve the performance which has been denoted as postactivation performance enhancement.
Objectives: This study determined the acute effects of different stretch-shortening (fast vs. low) and strength (dynamic vs. isometric) exercises executed during one training session on subsequent balance performance in youth weightlifters.
Materials and Methods: Sixteen male and female young weightlifters, aged 11.3±0.6years, performed four strength exercise conditions in randomized order, including dynamic strength (DYN; 3 sets of 3 repetitions of 10 RM) and isometric strength exercises (ISOM; 3 sets of maintaining 3s of 10 RM of back-squat), as well as fast (FSSC; 3 sets of 3 repetitions of 20-cm drop-jumps) and slow (SSSC; 3 sets of 3 hurdle jumps over a 20-cm obstacle) stretch-shortening cycle protocols. Balance performance was tested before and after each of the four exercise conditions in bipedal stance on an unstable surface (i.e., BOSU ball with flat side facing up) using two dependent variables, i.e., center of pressure surface area (CoP SA) and velocity (CoP V).
Results: There was a significant effect of time on CoP SA and CoP V [F(1,60)=54.37, d=1.88, p<0.0001; F(1,60)=9.07, d=0.77, p=0.003]. In addition, a statistically significant effect of condition on CoP SA and CoP V [F(3,60)=11.81, d=1.53, p<0.0001; F(3,60)=7.36, d=1.21, p=0.0003] was observed. Statistically significant condition-by-time interactions were found for the balance parameters CoP SA (p<0.003, d=0.54) and CoP V (p<0.002, d=0.70). Specific to contrast analysis, all specified hypotheses were tested and demonstrated that FSSC yielded significantly greater improvements than all other conditions in CoP SA and CoP V [p<0.0001 (d=1.55); p=0.0004 (d=1.19), respectively]. In addition, FSSC yielded significantly greater improvements compared with the two conditions for both balance parameters [p<0.0001 (d=2.03); p<0.0001 (d=1.45)].
Conclusion: Fast stretch-shortening cycle exercises appear to be more effective to improve short-term balance performance in young weightlifters. Due to the importance of balance for overall competitive achievement in weightlifting, it is recommended that young weightlifters implement dynamic plyometric exercises in the fast stretch-shortening cycle during the warm-up to improve their balance performance.
Patel, Riddhi P. ; Förster, Daniel W. ; Kitchener, Andrew C. ; Rayan, Mark D. ; Mohamed, Shariff W. ; Werner, Laura ; Lenz, Dorina ; Pfestorf, Hans ; Kramer-Schadt, Stephanie ; Radchuk, Viktoriia ; Fickel, Jörns ; Wilting, Andreas
Background. The bay cat Catopuma badia is endemic to Borneo, whereas its sister species the Asian golden cat Catopuma temminckii is distributed from the Himalayas and southern China through Indochina, Peninsular Malaysia and Sumatra. Based onmorphological data, up to five subspecies of the Asian golden cat have been recognized, but a taxonomic assessment, including molecular data and morphological characters, is still lacking. Results. We combined molecular data (whole mitochondrial genomes), morphological data (pelage) and species distribution projections (up to the Late Pleistocene) to infer how environmental changes may have influenced the distribution of these sister species over the past 120 000 years. The molecular analysis was based on sequenced mitogenomes of 3 bay cats and 40 Asian golden cats derived mainly from archival samples. Our molecular data suggested a time of split between the two species approximately 3.16 Ma and revealed very low nucleotide diversity within the Asian golden cat population, which supports recent expansion of the population. Discussion. The low nucleotide diversity suggested a population bottleneck in the Asian golden cat, possibly caused by the eruption of the Toba volcano in Northern Sumatra (approx. 74 kya), followed by a continuous population expansion in the Late Pleistocene/Early Holocene. Species distribution projections, the reconstruction of the demographic history, a genetic isolation-by-distance pattern and a gradual variation of pelage pattern support the hypothesis of a post-Toba population expansion of the Asian golden cat from south China/Indochina to PeninsularMalaysia and Sumatra. Our findings reject the current classification of five subspecies for the Asian golden cat, but instead support either a monotypic species or one comprising two subspecies: (i) the Sunda golden cat, distributed south of the Isthmus of Kra: C. t. temminckii and (ii) Indochinese, Indian, Himalayan and Chinese golden cats, occurring north of the Isthmus: C. t. moormensis.
Zouita, Sghaier ; Zouhal, Hassane ; Ferchichi, Habiba ; Paillard, Thierry ; Dziri, Catherine ; Hackney, Anthony C. ; Laher, Ismail ; Granacher, Urs ; Ben Moussa Zouita, Amira
Objective: We investigated the effects of combined balance and strength training on measures of balance and muscle strength in older women with a history of falls.
Methods: Twenty-seven older women aged 70.4 ± 4.1 years (age range: 65 to 75 years) were randomly allocated to either an intervention (IG, n = 12) or an active control (CG, n = 15) group. The IG completed 8 weeks combined balance and strength training program with three sessions per week including visual biofeedback using force plates. The CG received physical therapy and gait training at a rehabilitation center. Training volumes were similar between the groups. Pre and post training, tests were applied for the assessment of muscle strength (weight-bearing squat [WBS] by measuring the percentage of body mass borne by each leg at different knee flexions [0°, 30°, 60°, and 90°], sit-to-stand test [STS]), and balance. Balance tests used the modified clinical test of sensory interaction (mCTSIB) with eyes closed (EC) and opened (EO), on stable (firm) and unstable (foam) surfaces as well as spatial parameters of gait such as step width and length (cm) and walking speed (cm/s).
Results: Significant group × time interactions were found for different degrees of knee flexion during WBS (0.0001 < p < 0.013, 0.441 < d < 0.762). Post hoc tests revealed significant pre-to-post improvements for both legs and for all degrees of flexion (0.0001 < p < 0.002, 0.697 < d < 1.875) for IG compared to CG. Significant group × time interactions were found for firm EO, foam EO, firm EC, and foam EC (0.006 < p < 0.029; 0.302 < d < 0.518). Post hoc tests showed significant pre-to-post improvements for both legs and for all degrees of oscillations (0.0001 < p < 0.004, 0.753 < d < 2.097) for IG compared to CG. This study indicates that combined balance and strength training improved percentage distribution of body weight between legs at different conditions of knee flexion (0°, 30°, 60°, and 90°) and also decreased the sway oscillation on a firm surface with eyes closed, and on foam surface (with eyes opened or closed) in the IG.
Conclusion: The higher positive effects of training seen in standing balance tests, compared with dynamic tests, suggests that balance training exercises including lateral, forward, and backward exercises improved static balance to a greater extent in older women.