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From monthly mean observatory data spanning 1957-2014, geomagnetic field secular variation values were calculated by annual differences. Estimates of the spherical harmonic Gauss coefficients of the core field secular variation were then derived by applying a correlation based modelling. Finally, a Fourier transform was applied to the time series of the Gauss coefficients. This process led to reliable temporal spectra of the Gauss coefficients up to spherical harmonic degree 5 or 6, and down to periods as short as 1 or 2 years depending on the coefficient. We observed that a k(-2) slope, where k is the frequency, is an acceptable approximation for these spectra, with possibly an exception for the dipole field. The monthly estimates of the core field secular variation at the observatory sites also show that large and rapid variations of the latter happen. This is an indication that geomagnetic jerks are frequent phenomena and that significant secular variation signals at short time scales - i.e. less than 2 years, could still be extracted from data to reveal an unexplored part of the core dynamics.
Inside the EU Commission
(2017)
This article studies the perception of the EU Commission's Secretariat General in policy-making. Recently, research on EU institutions devotes increasing attention to analyzing structures and procedures of decision-making in EU institutions, most notably the EU Commission. Conventionally, the EU Commission is portrayed as a fragmented organization, divided along the lines of staff nationality, sectoral responsibilities and cabinets and General Directorates (DGs). The Secretariat General has long been viewed a weak actor that is hardly able or motivated to steer internal decision-making. However, recent research indicates a changing role of the Secretariat General as a pro-active broker and last arbiter. This article studies how the Secretariat General is perceived by the DGs in policy coordination and argues that this perception depends on the pattern of political authority, bureaucratic roles and the relevance and the alternatives prevailing in the policy field. The article is based on data from a survey among Commission officials.
Dem Text liegt ein Vortrag zugrunde, der auf dem 31. Motivationspsychologischen Kolloquium (MPK) in Heidelberg 2015 gehalten wurde. Im ersten Teil bietet er einen Überblick über die Motivationsforschung am Bochumer Heckhausen-Lehrstuhl in den 70er-Jahren („Bochumer Schule“). Dabei werden neben Heinz Heckhausen einzelne Mitarbeiter und ihre Schwerpunkte vorgestellt sowie das stimulierende Arbeitsklima an diesem Lehrstuhl beschrieben. Entsprechend der Vortragseinladung wird im Anschluss die Entwicklung der eigenen Forschungsschwerpunkte skizziert. Noch unter Heckhausens Leitung waren dies zunächst die Forschung zur Bezugsnormorientierung und die Einzelfallanalysen zur Lernmotivation mit dem Erweiterten Kognitiven Motivationsmodell. Danach geht der Vortrag auf Forschungsthemen ein, die dann in Heidelberg und Potsdam dazukamen. Hier geht es um die Erforschung von Tätigkeitsanreizen und um das Flow-Erleben. Abschließend wird der Potsdamer Versuch skizziert, herauszufinden, auf welche Weise unterschiedliche Motivationsqualitäten den Lernprozess und seine Resultate beeinflussen.
The invasion success of the cyanobacterium Cylindrospermopsis raciborskii in experimental mesocosms
(2017)
The potentially toxic, invasive cyanobacterium Cylindrospermopsis raciborskii, originating from sub-tropical regions, has spread into temperate climate zones in almost all continents. Potential factors in its success are temperature, light and nutrient levels. Grazing losses through zooplankton have been measured in the laboratory but are typically not regarded as a factor in (failed) invasion success. In some potentially suitable lakes, C. raciborskii has never been found, although it is present in water bodies close by. Therefore, we tested the invasive potential of three different isolates introduced into natural plankton communities using laboratory mesocosm experiments under three grazing levels: ambient zooplankton densities, removal of large species using 100 mu m mesh and a ca. doubling of large species. Three C. raciborskii isolates originating from the same geographic region (North-East Germany) were added separately to the four replicates of each treatment and kept in semi-continuous cultures for 21 days. Two isolates disappeared from the mesocosms and were also not viable in filtered lake water indicating that the lake water itself or the switch from culture medium to lake water led to the decay of the inoculated C. raciborskii. Only one out of the three isolates persisted in the plankton communities at a rather low level and only in the treatment without larger zooplankton. This result demonstrates that under potentially suitable environmental conditions, top-down control from zooplankton might hamper the establishment of C. raciborskii. Non-metric multidimensional scaling showed distinct variation in resident phytoplankton communities between the different grazing levels, thus differential grazing impact shaped the resident community in different ways allowing C. raciborskii only to invade under competitive (= low grazing pressure) conditions. Furthermore, even after invasion failure, the temporary presence of C. raciborskii influenced the phytoplankton community.
Due to increasing pressure on estuarine marshes from sea level rise and river training, there is a growing need to understand how species-environment relationships influence the zonation and growth of tidal marsh vegetation. In the present study, we investigated the distribution and stand characteristics of the two key brackish marsh species Bolboschoenus maritimus and Phragmites australis in the Elbe estuary together with several abiotic habitat factors. We then tested the effect of these habitat factors on plant growth and zonation with generalised linear models (GLMs). Our study provides detailed information on the importance of single habitat factors and their interactions for controlling the distribution patterns and stand characteristics of two key marsh species. Our results suggest that flow velocity is the main factor influencing species distribution and stand characteristics and together with soil-water salinity even affects the inundation tolerance of the two specie investigated here. Additionally, inundation height and duration as well as interspecific competition helped explain the distribution patterns and stand characteristics. By identifying the drivers of marsh zonation and stand characteristics and quantifying their effects, this study provides useful information for evaluating a future contribution of tidal marsh vegetation to ecosystem-based shore protection.
Much of the literature in the field of international relations is currently concerned with the changing patterns of authority in world politics. This is particularly evident in the policy domain of climate change, where a number of authors have observed a relocation of authority in global climate governance. These scholars claim that multilateral treaty making has lost much of its spark, and they emphasize the emergence of transnational governance arrangements, such as city networks, private certification schemes, and business self-regulation. However, the different types of interactions between the various transnational climate initiatives and the intergovernmental level have not been studied in much detail and only recently attracted growing scholarly interest. Therefore, the present article addresses this issue and focuses on the interplay between three different transnational climate governance arrangements and the international climate regime. The analysis in this article underscores that substate and nonstate actors have attained several authoritative functions in global climate policy making. Nevertheless, the three case studies also demonstrate that this development does not imply that we are witnessing a general shift of authority away from the intergovernmental level toward transnational actors. Instead, what can be observed in global climate governance is an ongoing reconfiguration of authority, which apparently reaffirms the centrality of the international climate regime. Thus, this article points to the need for a more nuanced perspective on the changing patterns of authority in global climate governance. In a nutshell, this study shows that the international climate regime is not the only location where the problem of climate change is addressed, while it highlights the persistent authority of state-based forms of regulation.
Narratives of Belonging
(2017)
Die Darstellungen genealogischer Netzwerke waren in der Antike Ausdruck der Weltsicht ihrer Erzähler, mit deren Hilfe Nähe und Distanz zwischen verschiedenen Gruppen und Völkern ausgedrückt und hergestellt werden konnte. Auch Paulus bedient sich genealogischer Argumente, um die Beziehung nicht-jüdischer Christus-Gläubiger zu Israel und ihrem Gott zu verdeutlichen. Es handelt sich um eine ethnozentrische Argumentation, deren Fokus aber gleichzeitig eindeutig theozentrisch ist.
Using a standard repeated measures model with arbitrary true score distribution and normal error variables, we present some fundamental closed-form results which explicitly indicate the conditions under which regression effects towards (RTM) and away from the mean are expected. Specifically, we show that for skewed and bimodal distributions many or even most cases will show a regression effect that is in expectation away from the mean, or that is not just towards but actually beyond the mean. We illustrate our results in quantitative detail with typical examples from experimental and biometric applications, which exhibit a clear regression away from the mean (‘egression from the mean’) signature. We aim not to repeal cautionary advice against potential RTM effects, but to present a balanced view of regression effects, based on a clear identification of the conditions governing the form that regression effects take in repeated measures designs.
The past two decades have witnessed widespread scholarly interest in the role of cities in climate policy-making. This research has considerably improved our understanding of the local level in the global response to climate change. The present article synthesizes the literature on local climate policies with respect to the 1.5 degrees C target. While most studies have focused on pioneering cities and networks, we contend that the broader impacts of local climate actions and their relationship to regional, national, and international policy frameworks have not been studied in enough detail. Against this backdrop, we introduce the concept of upscaling and contend that local climate initiatives must go hand in hand with higher-level policies and be better integrated into the multi-level governance system.
Circumstantial evidence suggests that magnetism and enhanced X-ray emission are likely correlated in early B-type stars: similar fractions of them (similar to 10%) are strong and hard X-ray sources and possess strong magnetic fields. It is also known that some B-type stars have spots on their surface. Yet up to now no X-ray activity associated with spots on early-type stars was detected. In this Letter we report the detection of a magnetic field on the B2V star rho Oph A. Previously, we assessed that the X-ray activity of this star is associated with a surface spot, herewith we establish its magnetic origin. We analyze spectra of rho Oph A obtained with the FORS2 spectrograph at ESO Very Large Telescope (VLT) at two epochs, and detect a longitudinal component of the magnetic field of the order of similar to 500 G in one of the datasets. The detection of the magnetic field only at one epoch can be explained by stellar rotation which is also invoked to explain observed periodic X-ray activity. From archival HARPS ESO VLT high resolution spectra we derived the fundamental stellar parameters of rho Oph A and further constrained its age. We conclude that rho Oph A provides strong evidence for the presence of active X-ray emitting regions on young magnetized early type stars.
To purchase or not?
(2017)
Although ecologically and socially responsible consumption helps to reduce the harmful effects of resource use for both nature and society, all types of consumption (whether green or fair) deplete valuable resources. At the same time, to maintain household financial sustainability, spending should not exceed a household's financial resources. Thus, economically sustainable consumption is related to the consumer's decision to not buy products and the disposition to forgo specific purchases. Based on a means-end chain approach, this study investigates consumer cognitive decision-making structures related to six distinct options for economically (non-)sustainable consumption. Whereas saving motives, waste concerns, and avoidance motivations support economically sustainable decisions, economically non-sustainable decision-making is directly linked to attaining overall life goals. By clustering respondents based on the elicited means-end chains, the study discloses four consumer groups with distinctive motivational structures. The study also reveals several obstacles to promoting economic sustainability, indicates methods to overcome such obstacles, and suggests avenues for future research.
Anhand von Daten der Mannheimer Risikokinderstudie, die sich mit der langfristigen Entwicklung von Kindern mit unterschiedlichen Risikobelastungen beschäftigt, wird gezeigt, wie Schutzfaktoren aufseiten des Kindes und seines familiären Umfelds im Verlauf der Entwicklung wirksam werden und zur Entstehung von Resilienz beitragen können. Eine besondere Rolle kommt dabei positiven frühen Eltern-Kind-Beziehungen zu (sowohl Mutter- als auch Vater-Kind-Interaktionen). Daneben spielen auch Interaktionserfahrungen im Alter von zwei Jahren des Kindes eine bedeutsame Rolle; diese schützen Risikokinder davor, eine ungünstige Entwicklung zu nehmen und tragen dazu bei, dass sich Kinder, die in psychosozialen Hochrisikofamilien aufwachsen, trotz ungünstiger „Startbedingungen“ positiv entwickeln. Neben Merkmalen der sozialen Umwelt nehmen auch sprachliche, sozial-emotionale und internale Kompetenzen des Kindes im Entwicklungsverlauf eine wichtige Rolle ein. Diese Kompetenzen ermöglichen es Risikokindern auch unter widrigen Lebensumständen (psychosoziale Hochrisikofamilien, Aufwachsen in Armutsverhältnissen) erfolgreich zu bestehen. Darüber hinaus zeigt die Arbeit, dass Resilienz ein Persönlichkeitsmerkmal ist, das ab dem frühen Erwachsenenalter eine hohe Stabilität besitzt. Mit diesen Befunden verweist die Arbeit auf die große Bedeutung der Resilienz bei der Vorhersage der langfristigen Entwicklung von Risikokindern.
For an arbitrary euclidean field F we introduce a central extension (G(F), Phi) of SL(2, F) admitting a left-ordering and study its algebraic properties. The elements of G(F) are order preserving bijections of the convex hull of Q in F. If F = R then G(F) is isomorphic to the classical universal covering group of the Lie group SL(2, R). Among other results we show that G(F) is a perfect group which possesses a rank 1 cone of exceptional type. We also prove that its centre is an infinite cyclic group and investigate its normal subgroups.
DPP4 inhibition prevents AKI
(2017)
To investigate and compare the occurrence of inflammatory processes in the sites of disc degeneration in the lumbar and cervical spine by a gene array and subsequent qPCR and to investigate the mechanistic involvement of transient receptor potential channels TRPC6 and TRPV4. The gene expression of inflammatory cytokines and TRP channels was measured in human disc samples obtained from patients undergoing discectomy at the cervical (n = 24) or lumbar (n = 27) spine for degenerative disc disease (DDD) and disc herniation (DH) and analyzed for differences with regard to spinal level, IVD degeneration grade, Modic grade, age, sex, disc region and surgical extent. Aside from genes with known implication in DDD and DH, four previously unreported genes from the interferon and TRP families (IFNA1, IFNA8, IFNB1, TRPC6) could be detected. A correlation between gene expression and age (IL-15) and IVD degeneration grade (IFNA1, IL-6, IL-15, TRPC6), but not Modic grade, was identified. Significant differences were detected between cervical and lumbar discs (IL-15), nucleus and annulus (IL-6, TNF-alpha, TRPC6), single-level and multi-level surgery (IL-6, IL-8) as well as DDD and DH (IL-8), while sex had no effect. Multiple gene-gene pair correlations, either between different cytokines or between cytokines and TRP channels, exist in the disc. This study supports the relevance of IL-6 and IL-8 in disc diseases, but furthermore points toward a possible pathological role of IL-15 and type I interferons, as well as a mechanistic role of TRPC6. With limited differences in the inflammatory profile of cervical and lumbar discs, novel anti-inflammatory or TRP-modulatory strategies for the treatment of disc pathologies may be applicable independent of the spinal region.
Galaxies are surrounded by sizeable gas reservoirs which host a significant amount of metals: the circum-galactic medium (CGM). The CGM acts as a mediator between the galaxy and the extragalactic medium. However, our understanding of how galaxy mergers, a major evolutionary transformation, impact the CGM remains deficient. We present a theoretical study of the effect of galaxy mergers on the CGM. We use hydrodynamical cosmological zoom-in simulations of a major merger selected from the Illustris project such that the z = 0 descendant has a halo mass and stellar mass comparable to the Milky Way. To study the CGM we then re-simulated this system at a 40 times better mass resolution, and included detailed post-processing ionization modelling. Our work demonstrates the effect the merger has on the characteristic size of the CGM, its metallicity, and the predicted covering fraction of various commonly observed gas-phase species, such as H I, C IV, and O VI. We show that merger-induced outflows can increase the CGM metallicity by 0.2-0.3 dex within 0.5 Gyr post-merger. These effects last up to 6 Gyr post-merger. While the merger increases the total metal covering fractions by factors of 2-3, the covering fractions of commonly observed UV ions decrease due to the hard ionizing radiation from the active galactic nucleus, which we model explicitly. Our study of the single simulated major merger presented in this work demonstrates the significant impact that a galaxy interaction can have on the size, metallicity, and observed column densities of the CGM.
This study examines the variations of climate variables and rice yield and quantifies the relationships among them using multiple linear regression, principal component analysis, and support vector machine (SVM) analysis in southwest Nigeria. The climate and yield data used was for a period of 36 years between 1980 and 2015. Similar to the observed decrease (P < 0.001) in rice yield, pan evaporation, solar radiation, and wind speed declined significantly. Eight principal components exhibited an eigenvalue > 1 and explained 83.1% of the total variance of predictor variables. The SVM regression function using the scores of the first principal component explained about 75% of the variance in rice yield data and linear regression about 64%. SVM regression between annual solar radiation values and yield explained 67% of the variance. Only the first component of the principal component analysis (PCA) exhibited a clear long-term trend and sometimes short-term variance similar to that of rice yield. Short-term fluctuations of the scores of the PC1 are closely coupled to those of rice yield during the 1986-1993 and the 2006-2013 periods thereby revealing the inter-annual sensitivity of rice production to climate variability. Solar radiation stands out as the climate variable of highest influence on rice yield, and the influence was especially strong during monsoon and post-monsoon periods, which correspond to the vegetative, booting, flowering, and grain filling stages in the study area. The outcome is expected to provide more in-depth regional-specific climate-rice linkage for screening of better cultivars that can positively respond to future climate fluctuations as well as providing information that may help optimized planting dates for improved radiation use efficiency in the study area.
In assessing adolescent behavior difficulties, parents, teachers, and the adolescents themselves are key informants. However, substantial disagreement has been found between informants. Specifically, children with attention-deficit/hyperactivity disorder (ADHD) tend to overestimate their competencies, also known as "positive (illusionary) bias." This study compared parent, teacher, and adolescent ratings of ADHD and other behavioral symptoms in a sample of 114 adolescents with ADHD. Further, the effect of cross-informant disagreement (CID) on treatment outcomes was investigated in a subsample of 54 adolescents who had undergone a training and coaching intervention. Overall, there was moderate agreement among informants. Parent and adolescent ratings were more strongly correlated with each other than with teacher ratings. The strongest discrepancy was found between teacher and adolescent ratings on prosocial behavior. This discrepancy explained 12% of the variance in parent-rated ADHD symptom severity after the intervention. The treatment was less effective in participants with high teacher-adolescent disagreement on prosocial behavior (d = 0.41) than with low disagreement (d = 0.98). These findings suggest that professionals working with adolescents with ADHD should consider multiple sources of information before initiating treatment and pay attention to cross-informant disagreements because these may indicate a risk of diminished treatment effects.
This article explores the various futures of relations between the European Union (EU) and Ukraine. After distilling two major drivers we construct a future compass in order to conceive of four futures of relations between the EU and Ukraine. Our scenarios aim to challenge deep-rooted assumptions on the EU’s neighbourhood with Ukraine: How will the politico-economic challenges in the European countries influence the EU’s approach towards the East? Will more EU engagement in Ukraine contribute to enduring peace? Does peace always come with stability? Which prospects does the idea of Intermarium have? Are the pivotal transformation players in Ukraine indeed oligarchs or rather small- and medium-sized entrepreneurs? After presenting our scenarios, we propose indicators to know in the years to come, along which path future relations do develop. By unearthing surprising developments we hope to provoke innovative thoughts on Eastern Europe in times of post truth societies, confrontation between states and hybrid warfare.
Ancient genomes have revolutionized our understanding of Holocene prehistory and, particularly, the Neolithic transition in western Eurasia. In contrast, East Asia has so far received little attention, despite representing a core region at which the Neolithic transition took place independently similar to 3 millennia after its onset in the Near East. We report genome-wide data from two hunter-gatherers from Devil's Gate, an early Neolithic cave site (dated to similar to 7.7 thousand years ago) located in East Asia, on the border between Russia and Korea. Both of these individuals are genetically most similar to geographically close modern populations from the Amur Basin, all speaking Tungusic languages, and, in particular, to the Ulchi. The similarity to nearby modern populations and the low levels of additional genetic material in the Ulchi imply a high level of genetic continuity in this region during the Holocene, a pattern that markedly contrasts with that reported for Europe.
The performance of hybridization capture combined with next-generation sequencing (NGS) has seen limited investigation with samples from hot and arid regions until now. We applied hybridization capture and shotgun sequencing to recover DNA sequences from bone specimens of ancient-domestic dromedary (Camelus dromedarius) and its extinct ancestor, the wild dromedary from Jordan, Syria, Turkey and the Arabian Peninsula, respectively. Our results show that hybridization capture increased the percentage of mitochondrial DNA (mtDNA) recovery by an average 187-fold and in some cases yielded virtually complete mitochondrial (mt) genomes at multifold coverage in a single capture experiment. Furthermore, we tested the effect of hybridization temperature and time by using a touchdown approach on a limited number of samples. We observed no significant difference in the number of unique dromedary mtDNA reads retrieved with the standard capture compared to the touchdown method. In total, we obtained 14 partial mitochondrial genomes from ancient-domestic dromedaries with 17-95% length coverage and 1.27-47.1-fold read depths for the covered regions. Using whole-genome shotgun sequencing, we successfully recovered endogenous dromedary nuclear DNA (nuDNA) from domestic and wild dromedary specimens with 1-1.06-fold read depths for covered regions. Our results highlight that despite recent methodological advances, obtaining ancient DNA (aDNA) from specimens recovered from hot, arid environments is still problematic. Hybridization protocols require specific optimization, and samples at the limit of DNA preservation need multiple replications of DNA extraction and hybridization capture as has been shown previously for Middle Pleistocene specimens.
microRNAs (miRNAs) have been identified as high-value drug targets. A widely applied strategy in miRNA inhibition is the use of antisense agents. However, it has been shown that oligonucleotides are poorly cell permeable because of their complex chemical structure and due to their negatively charged backbone. Consequently, the general application of oligonucleotides in therapy is limited. Since miRNAs’ functions are executed exclusively by the Argonaute 2 protein, we therefore describe a protocol for the design of a novel miRNA inhibitor class: antagonists of the miRNA-Argonaute 2 protein complex, so-called anti-miR-AGOs, that not only block the crucial binding site of the target miRNA but also bind to the protein’s active site. Due to their lower molecular weight and, thus, more drug-like chemical structure, the novel inhibitor class may show better pharmacokinetic properties than reported oligonucleotide inhibitors, enabling them for potential therapeutic use.
miRNA Targeting Drugs
(2017)
Only 20 years after the discovery of small non-coding, single-stranded ribonucleic acids, so-called microRNAs (miRNAs), as post-transcriptional gene regulators, the first miRNA-targeting drug Miravirsen for the treatment of hepatitis C has been successfully tested in clinical Phase II trials. Addressing miRNAs as drug targets may enable the cure, or at least the treatment of diseases, which presently seems impossible. However, due to miRNAs’ chemical structure, generation of potential drug molecules with necessary pharmacokinetic properties is still challenging and requires a re-thinking of the drug discovery process. Therefore, this chapter highlights the potential of miRNAs as drug targets, discusses the challenges, and tries to give a complete overview of recent strategies in miRNA drug discovery.
Drug target miRNA
(2017)
This volume provides a concise and technical discussion of recently developed approaches to overcome challenges in miRNA drug discovery. Drug Target miRNA: Methods and Protocols explores strategies to overcome pharmacodynamics and pharmacokinetics challenges. These strategies cover anti-sense agents targeting miRNA that are applied in advanced formulations or are chemically optimized to increase delivery; small molecule miRNA modulators to overcome anti-sense agents’ limitations; general enhancers of miRNA maturation; and Argonaute 2 protein and its pharmacokinetic parameters. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and thorough, Drug Target miRNA: Methods and Protocols is a valuable resource for anyone interested in the ever-evolving field of miRNA drug discovery.
Preface
(2017)
We introduce an abstract concept of quantum field theory on categories fibered in groupoids over the category of spacetimes. This provides us with a general and flexible framework to study quantum field theories defined on spacetimes with extra geometric structures such as bundles, connections and spin structures. Using right Kan extensions, we can assign to any such theory an ordinary quantum field theory defined on the category of spacetimes and we shall clarify under which conditions it satisfies the axioms of locally covariant quantum field theory. The same constructions can be performed in a homotopy theoretic framework by using homotopy right Kan extensions, which allows us to obtain first toy-models of homotopical quantum field theories resembling some aspects of gauge theories.
Background
Cells are able to communicate and coordinate their function within tissues via secreted factors. Aberrant secretion by cancer cells can modulate this intercellular communication, in particular in highly organised tissues such as the liver. Hepatocytes, the major cell type of the liver, secrete Dickkopf (Dkk), which inhibits Wnt/ β-catenin signalling in an autocrine and paracrine manner. Consequently, Dkk modulates the expression of Wnt/ β-catenin target genes. We present a mathematical model that describes the autocrine and paracrine regulation of hepatic gene expression by Dkk under wild-type conditions as well as in the presence of mutant cells.
Results
Our spatial model describes the competition of Dkk and Wnt at receptor level, intra-cellular Wnt/ β-catenin signalling, and the regulation of target gene expression for 21 individual hepatocytes. Autocrine and paracrine regulation is mediated through a feedback mechanism via Dkk and Dkk diffusion along the porto-central axis. Along this axis an APC concentration gradient is modelled as experimentally detected in liver. Simulations of mutant cells demonstrate that already a single mutant cell increases overall Dkk concentration. The influence of the mutant cell on gene expression of surrounding wild-type hepatocytes is limited in magnitude and restricted to hepatocytes in close proximity. To explore the underlying molecular mechanisms, we perform a comprehensive analysis of the model parameters such as diffusion coefficient, mutation strength and feedback strength.
Conclusions
Our simulations show that Dkk concentration is elevated in the presence of a mutant cell. However, the impact of these elevated Dkk levels on wild-type hepatocytes is confined in space and magnitude. The combination of inter- and intracellular processes, such as Dkk feedback, diffusion and Wnt/ β-catenin signal transduction, allow wild-type hepatocytes to largely maintain their gene expression.
West German anticommunism and the SED’s Westarbeit were to some extentinterrelated. From the beginning, each German state had attemted to stabilise itsown social system while trying to discredit its political opponent. The claim tosole representation and the refusal to acknowledge each other delineated governmentalaction on both sides. Anticommunism inWest Germany re-developed under theconditions of the Cold War, which allowed it to become virtually the reason ofstate and to serve as a tool for the exclusion of KPD supporters. In its turn, theSED branded the West German State as‘revanchist’and instrumentalised itsanticommunism to persecute and eliminate opponents within the GDR. Bothphenomena had an integrative and exclusionary element.
With its transparent orthography, Standard Indonesian is spoken by over 160 million inhabitants and is the primary language of instruction in education and the government in Indonesia. An assessment battery of reading and reading-related skills was developed as a starting point for the diagnosis of dyslexia in beginner learners. Founded on the International Dyslexia Association’s definition of dyslexia, the test battery comprises nine empirically motivated reading and reading-related tasks assessing word reading, pseudoword reading, arithmetic, rapid automatized naming, phoneme deletion, forward and backward digit span, verbal fluency, orthographic choice (spelling), and writing. The test was validated by computing the relationships between the outcomes on the reading-skills and reading-related measures by means of correlation and factor analyses. External variables, i.e., school grades and teacher ratings of the reading and learning abilities of individual students, were also utilized to provide evidence of its construct validity. Four variables were found to be significantly related with reading-skill measures: phonological awareness, rapid naming, spelling, and digit span. The current study on reading development in Standard Indonesian confirms findings from other languages with transparent orthographies and suggests a test battery including preliminary norm scores for screening and assessment of elementary school children learning to read Standard Indonesian.
Theoretischer Hintergrund:Supervision spielt eine zentrale Rolle zum Wissens- und Kompetenzerwerb sowie in der Qualitätssicherung.
Fragestellung:Ziel war es, den aktuellen Forschungsstand zur Supervision im Rahmen der kognitiven Verhaltenstherapie abzubilden, um daraus Schlussfolgerungen für die zukünftige Forschung abzuleiten.
Methode:Zur Evidenzsynthese wurde ein Scoping Review durchgeführt, das die Darstellung zentraler Konzepte, aktueller Evidenz und möglicher Forschungsbedarfe ermöglichte. Neben einer systematischen Literaturrecherche wurden Vorwärts- und Rückwärtssuchstrategien eingesetzt.
Ergebnisse:Eingeschlossen wurden zwölf Publikationen basierend auf zehn empirischen Studien. Alle Studien beschrieben Ausbildungssettings, aber nur wenige untersuchten übende Interventionen (z. B. Rollenspiele). Häufig wurden Effekte subjektiv erfasst, die methodische Qualität der Begleitstudien variierte.
Schlussfolgerungen:Notwendig sind weitere methodisch hochwertige Studien, experimentell orientiert oder in der klinischen Praxis, die die Supervisionsforschung bereichern können.
Coping, taming or solving
(2017)
One of the truisms of policy analysis is that policy problems are rarely solved. As an ever-increasing number of policy issues are identified as an inherently ill-structured and intractable type of wicked problem, the question of what policy analysis sets out to accomplish has emerged as more central than ever. If solving wicked problems is beyond reach, research on wicked problems needs to provide a clearer understanding of the alternatives. The article identifies and explicates three distinguishable strategies of problem governance: coping, taming and solving. It shows that their intellectual premises and practical implications clearly contrast in core respects. The article argues that none of the identified strategies of problem governance is invariably more suitable for dealing with wicked problems. Rather than advocate for some universally applicable approach to the governance of wicked problems, the article asks under what conditions different ways of governing wicked problems are analytically reasonable and normatively justified. It concludes that a more systematic assessment of alternative approaches of problem governance requires a reorientation of the debate away from the conception of wicked problems as a singular type toward the more focused analysis of different dimensions of problem wickedness.
This study investigates the comprehension of wh-questions in individuals with aphasia (IWA) speaking Turkish, a non-wh-movement language, and German, a wh-movement language. We examined six German-speaking and 11 Turkish-speaking IWA using picture-pointing tasks. Findings from our experiments show that the Turkish IWA responded more accurately to both object who and object which questions than to subject questions, while the German IWA performed better for subject which questions than in all other conditions. Using random forest models, a machine learning technique used in tree-structured classification, on the individual data revealed that both the Turkish and German IWA’s response accuracy is largely predicted by the presence of overt and unambiguous case marking. We discuss our results with regard to different theoretical approaches to the comprehension of wh-questions in aphasia.
Innovationen sind wie ein Motor, der unser ökonomisches, soziales und ge-sellschaftliches Leben antreibt und laufend verändert. Ob in der Medizin-technik, Luft- und Raumfahrt, Energiegewinnung, im Netz oder in der Schule: In allen Bereichen sorgen Innovationen für die stetige Weiterent-wicklung unser Gesellschaft. Bernd Meier hat die Bedeutung von Innova-tionen und innovativem Denken für die technische Bildung und Schule früh erkannt. Mit einer kurzen Rückschau auf sein Wirken hinsichtlich der Be-deutung von Innovationen für die technische und ökonomische Bildung soll ein wichtiger Bereich seiner Arbeit gewürdigt werden. Zu Beginn wird der Innovationsbegriff allgemein umrissen und dann mit Blick auf Schule präzi-siert. Danach wird dargestellt, welchen Stellenwert die Thematik Innovation und Technologie nicht nur in den Publikationen von Bernd Meier, sondern auch in seinen Lehrkonzeptionen eingenommen hat. Im Anschluss daran wird diskutiert, warum es gerade im Bildungsbereich so schwer ist, innova-tiv zu sein oder dauerhaft Innovationen durchzusetzen.1 Der Beitrag endet mit einem Ausblick, inwiefern Innovationen auch in Zukunft für Schule und das Fach Wirtschaft-Arbeit-Technik (kurz: WAT) eine wichtige Thematik darstellen sollten.
The Bajgan Complex, one of the basement constituents of the arc massif in Iranian Makran forms a rugged, deeply incised terrain. The complex consists of pelitic schists with minor psammitic and basic schists, calc silicate rocks, amphibolites, marbles, metavolcanosediments, mafic and felsic intrusives as well as ultramafic rocks. Metapelitic rocks show an amphibolite facies regional metamorphism and contain garnet, biotite, white mica, quartz, albite ± rutile ± apatite. Thermobarometry of garnet schist yields pressure of more than 9 kbar and temperatures between 560 and 675 °C. The geothermal gradient obtained for the peak of regional metamorphism is 19 °C/km, corresponding to a depth of ca. 31 km. Replacement of garnet by chlorite and epidote suggest greenschist facies metamorphism due to a decrease in temperature and pressure through exhumation and retrograde metamorphism (370–450 °C and 3–6 kbar). The metapelitic rocks followed a ‘clockwise’ P–T path during metamorphism, consistent with thermal decline following tectonic thickening. The formation of medium-pressure metamorphic rocks is related to presence of active subduction of the Neotethys Oceanic lithosphere beneath Eurasia in the Makran.
Anthropologists all over the world are discussing influences on individual height including quantity and quality of nutrition. To examine whether a relationship between nutritional components and height can be found this pilot study has been developed. The research samples consisted of 44 children (age 3–6 years) attending two different kindergartens in Germany. Height measurements were taken for each child. Furthermore the parents had to fill out a 24-hour questionnaire to document their children’s eating habits during the weekend. In order to standardize the measured height values z-scores were calculated with reference to the average height of the overall cohort. The results of correlation analysis indicate that height is not significantly related to any of the main nutritional components as protein (r = –0.148), carbohydrates (r = 0.126), fat (r = 0.107), fibre (r = –0.289), vitamin (r = 0.050), calcium (r = 0.110), potassium (r = 0.189) and overall calorie intake (r = 0.302). In conclusion, it can be stated that the quality of nutrition may not have a strong influence on individual height. However, due to the small sample size further research should be provided with a larger cohort of children to verify the present results.
A Gateway to the World
(2017)
In the second half of the 19th century, the French École centrale des arts et manufactures became one of the engineering schools that enjoyed a worldwide reputation. There were many foreigners among its students. This article focuses on the graduates born in the Ottoman Empire, particularly on Jews and Armenians. It analyses their backgrounds, their common features and their professional careers, tracing their links with other centraliens. The patterns in the Ottoman centraliens’ professional trajectories help us picture a world full of opportunities where highly qualified men could cross borders and build careers with ease, but where, at the same time, origins, allegiances, contacts and credentials mattered greatly.
Purpose - This study aims to investigate whether a team of females negotiates differently than a team of males, and whether (workplace) friendship moderates the relationship between single-gender team composition and negotiation outcomes. Design/methodology/approach - The authors used two laboratory studies and paired 216 MBA students into single-gender teams of friends and non-friends, and then engaged them in several dyadic multi-issue negotiations. Findings - The results show that on average, male teams of non-friends reached significantly better outcomes than female teams of non-friends. However, and interestingly, female teams of friends perform equally to male teams of friends. Research limitations/implications - The authors contribute both to the negotiations and the workplace friendship literature because very little research has examined negotiation among friends at work and in particular team negotiations. In addition, the authors also contribute to the literature on gender differences in negotiations because existing research has rarely examined the differences between all-male and all-female teams and especially the relationship between same-sex teams and their effects on negotiation outcomes. Practical implications - This research has clear implications to managers with regard to team composition. Specifically, a winning all-female team should not be changed! Originality/value - This is the first study to examine the relationship between workplace friendship, gender and negotiation outcomes.
Effects of aging on lexical processing are well attested, but the picture is less clear for grammatical processing. Where age differences emerge, these are usually ascribed to working-memory (WM) decline. Previous studies on the influence of WM on agreement computation have yielded inconclusive results, and work on aging and subject-verb agreement processing is lacking. In two experiments (Experiment 1: timed grammaticality judgment, Experiment 2: self-paced reading + WM test), we investigated older (OA) and younger (YA) adults’ susceptibility to agreement attraction errors. We found longer reading latencies and judgment reaction times (RTs) for OAs. Further, OAs, particularly those with low WM scores, were more accepting of sentences with attraction errors than YAs. OAs showed longer reading latencies for ungrammatical sentences, again modulated by WM, than YAs. Our results indicate that OAs have greater difficulty blocking intervening nouns from interfering with the computation of agreement dependencies. WM can modulate this effect.
Changes in body height throughout extended historic periods are very complex and dynamic processes. Thispilot study aimed to investigate the pattern of longitudinal height z-scores changes in children before and after entering kindergarten. In summer 2016, we measured height and weight of 32 children from 4 groups of two kindergartens aged 3–6 years. All ages were centered according to the age of entry into the kindergarten. For each child we determined mean z-scores for height before and after entering the kindergarten, and assessed the variances for each kindergarten group. Twenty-two children targeted in height z-scores towards average height of their respective kindergarten group, 10 children did not. Due to the small numbers, the convergence in height variance however, remained insignificant (chi-squared independence test, p = 0.127). Additional studies with larger sample sizes are needed to confirm this pilot study.
Gamma-ray bursts (GRBs) are some of the Universe’s most enigmatic and exotic events. However, at energies above 10 GeV their behaviour remains largely unknown. Although space based telescopes such as the Fermi-LAT have been able to detect GRBs in this energy range, their photon statistics are limited by the small detector size. Such limitations are not present in ground based gamma-ray telescopes such as the H.E.S.S. experiment, which has now entered its second phase with the addition of a large 600 m2 telescope to the centre of the array. Such a large telescope allows H.E.S.S. to access the sub 100-GeV energy range while still maintaining a large effective collection area, helping to potentially probe the short timescale emission of these events.
We present a description of the H.E.S.S. GRB observation programme, summarising the performance of the rapid GRB repointing system and the conditions under which GRB observations are initiated. Additionally we will report on the GRB follow-ups made during the 2014-15 observation campaigns.
HESS J1826-130
(2017)
HESS J1826-130 is an unidentified hard spectrum source discovered by H.E.S.S. along the Galactic plane, the spectral index being Gamma = 1.6 with an exponential cut-off at about 12 TeV. While the source does not have a clear counterpart at longer wavelengths, the very hard spectrum emission at TeV energies implies that electrons or protons accelerated up to several hundreds of TeV are responsible for the emission. In the hadronic case, the VHE emission can be produced by runaway cosmic-rays colliding with the dense molecular clouds spatially coincident with the H.E.S.S. source.
Background: We sought to develop a standardized protocol for ultrasound (US) measurements of plantar fascia (PF) width and cross-sectional area (CSA), which may serve as additional outcome variables during US examinations of both healthy asymptomatic PF and in plantar fasciopathy and determine its interrater and intrarater reliability. Methods: Ten healthy individuals (20 feet) were enrolled. Participants were assessed twice by two raters each to determine intrarater and interrater reliability. For each foot, three transverse scans of the central bundle of the PF were taken at its insertion at the medial calcaneal tubercle, identified in real time on the plantar surface of the foot, using a fine wire technique. Reliability was determined using intraclass correlation coefficients (ICC), standard errors of measurement (SEM), and limits of agreement (LOA) expressed as percentages of the mean. Reliability of PF width and CSA measurements was determined using PF width and CSA measurements from one sonogram measured once and the mean of three measurements from three sonograms each measured once. Results: Ultrasound measurements of PF width and CSA showed a mean of 18.6 +/- 2.0 mm and 69.20 +/- 13.6 mm(2) respectively. Intra-reliability within both raters showed an ICC. 0.84 for width and ICC. 0.92 for CSA as well as a SEM% and LOA%, 10% for both width and CSA. Inter-rater reliability showed an ICC of 0.82 for width and 0.87 for CSA as well as a SEM% and LOA%, 10% for width and a SEM%, 10% and LOA%, 20% for CSA. Relative and absolute reliability within and between raters were higher when using the mean of three sonographs compared to one sonograph. Conclusions: Using this novel technique, PF CSA and width may be determined reliably using measurements from one sonogram or the mean of three sonograms. Measurement of PF CSA and width in addition to already established thickness and echogenicity measurements provides additional information on structural properties of the PF for clinicians and researchers in healthy and pathologic PF.
The present study explores the perceptual span, that is, the physical extent of the area from which useful visual information is obtained during a single fixation, during oral reading of Chinese sentences. Characters outside a window of legible text were replaced by visually similar characters. Results show that the influence of window size on the perceptual span was consistent across different fixation and oculomotor measures. To maintain normal reading behavior when reading aloud, it was necessary to have information provided from three characters to the right of the fixation. Together with findings from previous research, our findings suggest that the physical size of the perceptual span is smaller when reading aloud than in silent reading. This is in agreement with previous studies in English, suggesting that the mechanisms causing the reduced span in oral reading have a common base that generalizes across languages and writing systems.
Intraplate seismicity is often characterized by episodic, clustered and migrating earthquakes and extended after-shock sequences. Can these observations - primarily from North America, China and Australia - usefully be applied to seismic hazard assessment for intraplate Europe? Existing assessments are based on instrumental and historical seismicity of the past c. 1000 years, as well as some data for active faults. This time span probably fails to capture typical large-event recurrence intervals of the order of tens of thousands of years. Palaeoseismology helps to lengthen the observation window, but preferentially produces data in regions suspected to be seismically active. Thus the expected maximum magnitudes of future earthquakes are fairly uncertain, possibly underestimated, and earthquakes are likely to occur in unexpected locations. These issues particularly arise in considering the hazards posed by low-probability events to both heavily populated areas and critical facilities. For example, are the variations in seismicity (and thus assumed seismic hazard) along the Rhine Graben a result of short sampling or are they real? In addition to a better assessment of hazards with new data and models, it is important to recognize and communicate uncertainties in hazard estimates. The more users know about how much confidence to place in hazard maps, the more effectively the maps can be used.
Modeling a secular trend by Monte Carlo simulation of height biased migration in a spatial network
(2017)
Background: In a recent Monte Carlo simulation, the clustering of body height of Swiss military conscripts within a spatial network with characteristic features of the natural Swiss geography was investigated. In this study I examined the effect of migration of tall individuals into network hubs on the dynamics of body height within the whole spatial network. The aim of this study was to simulate height trends. Material and methods: Three networks were used for modeling, a regular rectangular fishing net like network, a real world example based on the geographic map of Switzerland, and a random network. All networks contained between 144 and 148 districts and between 265-307 road connections. Around 100,000 agents were initially released with average height of 170 cm, and height standard deviation of 6.5 cm. The simulation was started with the a priori assumption that height variation within a district is limited and also depends on height of neighboring districts (community effect on height). In addition to a neighborhood influence factor, which simulates a community effect, body height dependent migration of conscripts between adjacent districts in each Monte Carlo simulation was used to re-calculate next generation body heights. In order to determine the direction of migration for taller individuals, various centrality measures for the evaluation of district importance within the spatial network were applied. Taller individuals were favored to migrate more into network hubs, backward migration using the same number of individuals was random, not biased towards body height. Network hubs were defined by the importance of a district within the spatial network. The importance of a district was evaluated by various centrality measures. In the null model there were no road connections, height information could not be delivered between the districts. Results: Due to the favored migration of tall individuals into network hubs, average body height of the hubs, and later, of the whole network increased by up to 0.1 cm per iteration depending on the network model. The general increase in height within the network depended on connectedness and on the amount of height information that was exchanged between neighboring districts. If higher amounts of neighborhood height information were exchanged, the general increase in height within the network was large (strong secular trend). The trend in the homogeneous fishnet like network was lowest, the trend in the random network was highest. Yet, some network properties, such as the heteroscedasticity and autocorrelations of the migration simulation models differed greatly from the natural features observed in Swiss military conscript networks. Autocorrelations of district heights for instance, were much higher in the migration models. Conclusion: This study confirmed that secular height trends can be modeled by preferred migration of tall individuals into network hubs. However, basic network properties of the migration simulation models differed greatly from the natural features observed in Swiss military conscripts. Similar network-based data from other countries should be explored to better investigate height trends with Monte Carlo migration approach.