Refine
Year of publication
Document Type
- Conference Proceeding (545) (remove)
Language
- English (458)
- German (74)
- Multiple languages (10)
- French (2)
- Russian (1)
Keywords
- Archiv (4)
- Information Structure (4)
- Nachlass (4)
- Cloud Computing (3)
- E-Learning (3)
- E-Mail Tracking (3)
- ERP (3)
- MOOC (3)
- Privacy (3)
- enterprise systems (3)
Institute
- Extern (139)
- Fachgruppe Betriebswirtschaftslehre (59)
- Institut für Biochemie und Biologie (56)
- Department Sport- und Gesundheitswissenschaften (40)
- Institut für Ernährungswissenschaft (36)
- Department Psychologie (29)
- Institut für Künste und Medien (23)
- Interdisziplinäres Zentrum für Musterdynamik und Angewandte Fernerkundung (23)
- Institut für Informatik und Computational Science (20)
- Institut für Slavistik (17)
Enterprise Resource Planning (ERP) system customization is often necessary because companies have unique processes that provide their competitive advantage. Despite new technological advances such as cloud computing or model-driven development, technical ERP customization options are either outdated or ambiguously formulated in the scientific literature. Using a systematic literature review (SLR) that analyzes 137 definitions from 26 papers, the result is an analysis and aggregation of technical customization types by providing clearance and aligning with future organizational needs. The results show a shift from ERP code modification in on-premises systems to interface and integration customization in cloud ERP systems, as well as emerging technological opportunities as a way for customers and key users to perform system customization. The study contributes by providing a clear understanding of given customization types and assisting ERP users and vendors in making customization decisions.
The holocaust in the USSR
(2021)
This paper sketches the current status of international scholarship on the subject of the Holocaust in the USSR and its place in the wider military conflict of the Second World War. Research on this topic over the last 20 to 30 years has been truly international and the findings of this research cannot be sketched here without pointing to the contributions made by German, American, Russian, Israeli, British and Australian historians. Historians from these countries have made important contributions to our understanding of key questions relating to this subject. These questions address, among other things, pre-invasion orders issued to German units; the radicalisation of German policy, culminating in the root-and-branch extermination of Soviet Jewry; the network of ghettos set up on Soviet territory; the nature of the killing and the methods used to murder these victims; the total death toll of the Holocaust in the USSR; and the relationship between war and extermination, in which genocide can be regarded as an actual strategy of warfare pursued by the German Reich.
To date, sex and gender differences play only a minor role in medical research and practice, thereby putting individuals’ health at risk. Gender-specific medicine, or the practice of taking these differences into account when conducting research and treating patients so far is being discussed primarily by experts. With people increasingly using social media such as Twitter for sharing and searching for health-related information online, Twitter can potentially educate about gender-specific medicine. However, little is known about the information circulation and the structure of interactions on the Twitter network discussing this topic. Results of a network analysis show that the network exhibits a community-structure, with information exchange being limited and concentrated in silos. This indicates that there is untapped potential for acquiring new information by users through interacting with individuals outside their community. Public health officials may benefit from this insight and tailor online campaigns to enhance awareness on gender-specific medicine.
Halide perovskites
(2021)
Background:
Anti-TNFα monoclonal antibodies (mAbs) are a well-established treatment for patients with Crohn’s disease (CD). However, subtherapeutic concentrations of mAbs have been related to a loss of response during the first year of therapy1. Therefore, an appropriate dosing strategy is crucial to prevent the underexposure of mAbs for those patients. The aim of our study was to assess the impact of different dosing strategies (fixed dose or body size descriptor adapted) on drug exposure and the target concentration attainment for two different anti-TNFα mAbs: infliximab (IFX, body weight (BW)-based dosing) and certolizumab pegol (CZP, fixed dosing). For this purpose, a comprehensive pharmacokinetic (PK) simulation study was performed.
Methods:
A virtual population of 1000 clinically representative CD patients was generated based on the distribution of CD patient characteristics from an in-house clinical database (n = 116). Seven dosing regimens were investigated: fixed dose and per BW, lean BW (LBW), body surface area, height, body mass index and fat-free mass. The individual body size-adjusted doses were calculated from patient generated body size descriptor values. Then, using published PK models for IFX and CZP in CD patients2,3, for each patient, 1000 concentration–time profiles were simulated to consider the typical profile of a specific patient as well as the range of possible individual profiles due to unexplained PK variability across patients. For each dosing strategy, the variability in maximum and minimum mAb concentrations (Cmax and Cmin, respectively), area under the concentration-time curve (AUC) and the per cent of patients reaching target concentration were assessed during maintenance therapy.
Results:
For IFX and CZP, Cmin showed the highest variability between patients (CV ≈110% and CV ≈80%, respectively) with a similar extent across all dosing strategies. For IFX, the per cent of patients reaching the target (Cmin = 5 µg/ml) was similar across all dosing strategies (~15%). For CZP, the per cent of patients reaching the target average concentration of 17 µg/ml ranged substantially (52–71%), being the highest for LBW-adjusted dosing.
Conclusion:
By using a PK simulation approach, different dosing regimen of IFX and CZP revealed the highest variability for Cmin, the most commonly used PK parameter guiding treatment decisions, independent upon dosing regimen. Our results demonstrate similar target attainment with fixed dosing of IFX compared with currently recommended BW-based dosing. For CZP, the current fixed dosing strategy leads to comparable percentage of patients reaching target as the best performing body size-adjusted dosing (66% vs. 71%, respectively).
Many prediction tasks can be done based on users’ trace data. This paper explores divergent and convergent thinking as person-related attributes and predicts them based on features gathered in an online course. We use the logfile data of a short Moodle course, combined with an image test (IMT), the Alternate Uses Task (AUT), the Remote Associates Test (RAT), and creative self-efficacy (CSE). Our results show that originality and elaboration metrics can be predicted with an accuracy of ~.7 in cross-validation, whereby predicting fluency and RAT scores perform worst. CSE items can be predicted with an accuracy of ~.45. The best performing model is a Random Forest Tree, where the features were reduced using a Linear Discriminant Analysis in advance. The promising results can help to adjust online courses to the learners’ needs based on their creative performances.
The devil in disguise
(2021)
Envy constitutes a serious issue on Social Networking Sites (SNSs), as this painful emotion can severely diminish individuals' well-being. With prior research mainly focusing on the affective consequences of envy in the SNS context, its behavioral consequences remain puzzling. While negative interactions among SNS users are an alarming issue, it remains unclear to which extent the harmful emotion of malicious envy contributes to these toxic dynamics. This study constitutes a first step in understanding malicious envy’s causal impact on negative interactions within the SNS sphere. Within an online experiment, we experimentally induce malicious envy and measure its immediate impact on users’ negative behavior towards other users. Our findings show that malicious envy seems to be an essential factor fueling negativity among SNS users and further illustrate that this effect is especially pronounced when users are provided an objective factor to mask their envy and justify their norm-violating negative behavior.