Refine
Year of publication
Document Type
- Article (36178) (remove)
Language
Keywords
- Germany (102)
- climate change (95)
- Sprachtherapie (58)
- stars: massive (58)
- Patholinguistik (53)
- morphology (53)
- patholinguistics (53)
- Nachhaltigkeit (50)
- German (48)
- diffusion (48)
Institute
- Institut für Physik und Astronomie (4230)
- Institut für Biochemie und Biologie (3803)
- Institut für Geowissenschaften (2832)
- Institut für Chemie (2417)
- Department Psychologie (1763)
- Institut für Romanistik (1469)
- Historisches Institut (1360)
- Wirtschaftswissenschaften (1161)
- Institut für Mathematik (1089)
- Department Linguistik (1053)
In the Universe, matter outside of stars and compact objects is mostly composed of collisionless plasma.
The interaction of a supersonic plasma flow with an obstacle results in collisionless shocks that are often associated with intense nonthermal radiation and the production of cosmic ray particles.
Motivated by simulations of non-relativistic high-Mach-number shocks in supernova remnants, we investigate the instabilities excited by relativistic electron beams in the extended foreshock of oblique shocks.
The phase-space distributions in the inner and outer foreshock regions are derived with a particle-in-cell simulation of the shock and used as initial conditions for simulations with periodic boundary conditions to study their relaxation toward equilibrium.
We find that the observed electron-beam instabilities agree very well with the predictions of a linear dispersion analysis: the electrostatic electron-acoustic instability dominates in the outer region of the foreshock, while the denser electron beams in the inner foreshock drive the gyroresonant oblique-whistler instability.
The purpose of this study was to examine the moderating effects of technology use for relationship maintenance on the longitudinal associations among self-isolation during the coronavirus-19 (COVID-19) pandemic and romantic relationship quality among adolescents. Participants were 239 (120 female; M age = 16.69, standard deviation [SD] = 0.61; 60 percent Caucasian) 11th and 12th graders from three midwestern high schools. To qualify for this study, adolescents had to be in the same romantic relationship for the duration of the study, similar to 7 months (M length of relationship = 10.03 months). Data were collected in October of 2019 (Time 1) and again 7 months later in May of 2020 (Time 2). Adolescents completed a romantic relationship questionnaire at Time 1 and again at Time 2, along with questionnaires on frequency of self-isolation during the COVID-19 pandemic and use of technology for romantic relationship maintenance. Findings revealed that increases in self-isolation during the COVID-19 pandemic related positively to the use of technology for romantic relationship maintenance and negatively to Time 2 romantic relationship quality. High use of technology for romantic relationship maintenance buffered against the negative effects of self-isolation during the COVID-19 pandemic on adolescents' romantic relationship quality 7 months later, whereas low use strengthened the negative relationship between self-isolation during the COVID-19 pandemic and romantic relationship quality. These findings suggest the importance of considering the implications of societal crisis or pandemics on adolescents' close relationships, particularly their romantic relationships.
Geochemical homogeneity in shale is often assumed when tracing subsurface fluids and characterizing sedimentary basins. This study presents measurements of the bulk gas composition, stable isotopes, and noble gas volume fraction and isotopes for shale gas samples collected from gas wells in the Wufeng-Longmaxi Shale, the southern Sichuan Basin, China. The dryness [C-1 /(C-2 + C-3)] ranging from 166.3 to 251.2, combined with delta C-13(1) and delta DC1 that vary from -28.8 to -27.3 parts per thousand and - 153 to -145 parts per thousand, respectively, point to a late mature thermogenic origin of hydrocarbon gas. He-3/He-4 ratios of gas samples are around 0.01 times the air value suggesting dominantly crust-derived He. Ne-21/Ne-22 and Ar-40/Ar-36 ratios of many gas samples are higher than the corresponding air values indicating the mixing of crustal and atmospheric noble gases. Multiple dichotomous patterns are observed in noble gas signatures of forelimb and backlimb samples, and depression and crest samples. Ne-20/Ne-22 ratios of some crest samples are higher than that of depression samples in the backlimb, pointing to the presence of diffusion-driven fractionation that is likely caused by the long-distance migration from depression to crest. Elemental ratios of air-derived noble gas isotopes - Ne-22/Ar-36, Kr-84/Ar-36, and Xe-132/Ar-36 are compared to the recharge water values, suggesting the interactions of oil, gas, and water phases in the shale over geologic time. Forelimb samples generally display older ages than backlimb samples, indicating a larger flux of external radiogenic He-4 due to the higher density of deep faults in the forelimb area caused by the basementinvolved deformation. The basement-involved deformation also causes pore collapse especially in the forelimb leading to a lower porosity that results in a more pristine noble gas signature in the forelimb due to the reduced impact of younger recharge water.
The present study examined the moderating role of parents' victimization status during adolescence in the associations between parenting styles, depression, and anxiety among relationally victimized adolescents. There were 436 relationally victimized adolescents (M age = 13.26 years, SD = .56) included in this study, along with their parents (n = 436; M age = 47.01 years, SD = .83; 86% mothers), from the Midwestern region of the United States (N = 872). Adolescents completed questionnaires on their experiences of relational victimization, depression, and anxiety, and perceptions of their parents' parenting styles. Their parents completed a questionnaire on their relational victimization status during adolescence. Findings from the study revealed that the relationships between the permissive parenting style, depression, and anxiety among relationally victimized adolescents were stronger when adolescents' parents were also victims of relational bullying during adolescence. These findings underscore the importance of considering parents' peer victimization history during adolescence.
Understanding the assembly mechanism and function of membrane proteins is a fundamental problem in biochemical research. Among the membrane proteins, G protein-coupled receptors (GPCRs) represent the largest class in the human body and have long been considered to function as monomers.
Nowadays, the oligomeric assembly of GPCRs is widely accepted, although the functional importance and therapeutic intervention remain largely unexplored. This is partly due to difficulties in the heterologous production of membrane proteins.
Cell-free protein synthesis (CFPS) with its endogenous endoplasmic reticulum-derived structures has proven as a technique to address this issue.
In this study, we investigate for the first time the conceptual CFPS of a heteromeric GPCR, the gamma-aminobutyric acid receptor type B (GABA(B)), from its protomers BR1 and BR2 using a eukaryotic cell-free lysate. Using a fluorescence-based proximity ligation assay, we provide evidence for colocalization and thus suggesting heterodimerization.
We prove the heterodimeric assembly by a bioluminescence resonance energy transfer saturation assay providing the manufacturability of a heterodimeric GPCR by CFPS. Additionally, we show the binding of a fluorescent orthosteric antagonist, demonstrating the feasibility of combining the CFPS of GPCRs with pharmacological applications.
These results provide a simple and powerful experimental platform for the synthesis of heteromeric GPCRs and open new perspectives for the modelling of protein-protein interactions.
Accordingly, the presented technology enables the targeting of protein assemblies as a new interface for pharmacological intervention in disease-relevant dimers.
Analysis of single event transient effects in standard delay cells based on decoupling capacitors
(2022)
Single Event Transients (SETs), i.e., voltage glitches induced in combinational logic as a result of the passage of energetic particles, represent an increasingly critical reliability threat for modern complementary metal oxide semiconductor (CMOS) integrated circuits (ICs) employed in space missions.
In rad-hard ICs implemented with standard digital cells, special design techniques should be applied to reduce the Soft Error Rate (SER) due to SETs.
To this end, it is essential to consider the SET robustness of individual standard cells. Among the wide range of logic cells available in standard cell libraries, the standard delay cells (SDCs) implemented with the skew-sized inverters are exceptionally vulnerable to SETs. Namely, the SET pulses induced in these cells may be hundreds of picoseconds longer than those in other standard cells.
In this work, an alternative design of a SDC based on two inverters and two decoupling capacitors is introduced. Electrical simulations have shown that the propagation delay and SET robustness of the proposed delay cell are strongly influenced by the transistor sizes and supply voltage, while the impact of temperature is moderate. The proposed design is more tolerant to SETs than the SDCs with skew-sized inverters, and occupies less area compared to the hardening configurations based on partial and complete duplication.
Due to the low transistor count (only six transistors), the proposed delay cell could also be used as a SET filter.
Enhanced protective performance of waterborne, microcontainers-doped coatings in harsh environments
(2021)
In this study, the corrosion inhibitors Zinc oleate and 8-Hydroxyquinoline were successfully encapsulated using an interfacial polyaddition method. As such they were dispersed at different concentrations within the waterborne coating matrix. The resulting composite coatings were applied to the low carbon steel substrates. Successful synthesis and morphological characteristics of microcontainers loaded with inhibitors were confirmed using various characterization techniques. Scanning electron microscopy, dynamic light scattering, and thermogravimetric measurements are techniques used to define the surface, dimensional, and dispersive characteristics of containers, and the share of encapsulated inhibitors. The release study defined the discharge kinetics of the corrosion inhibitor from the microcontainers dispersed freely in an aqueous medium. Electrochemical impedance spectroscopy was used to determine the anticorrosive performance of the samples continuously exposed to various corrosive environments of salt and humidity chambers and NaCl solution. Special emphasis was placed on adhesion testing and visual observations during the exposure period. Significant improvements have been noted in terms of corrosion resistance, which, however, depend on the type of inhibitor used, the concentration of the containers embedded in the coating matrix and on the characteristics of the corrosive environment.
Turkish 3rd person plural subjects are frequently used with verbs that are unmarked for number, with plural suffix omission influenced by semantic and word-order related constraints.
Previous findings from judgment tasks indicate that monolingual and heritage Turkish speakers differ in the way they are affected by these constraints.
This study builds and expands upon previous research by investigating the role of word order in more detail, and by examining whether the constraint weightings obtained from Uygun and Felser's (2021) acceptability judgment data are able to predict speakers' verb form choices in a timed sentence completion task.
Besides confirming that word-order related constraints are information-structural in nature, our results show that heritage speakers over-produce plural-marked verbs in comparison to monolingual speakers, indicating between-group differences in constraint ranking.
We interpret this as reflecting a tendency among Turkish heritage speakers to regularize the agreement system, which is not necessarily observed in metalinguistic judgment tasks.
In the area of cardiac monitoring, the use of digitally driven technologies is on the rise. While the development of medical products is advancing rapidly, allowing for new use-cases in cardiac monitoring and other areas, regulatory and legal requirements that govern market access are often evolving slowly, sometimes creating market barriers. This article gives a brief overview of the existing clinical studies regarding the use of smart wearables in cardiac monitoring and provides insight into the main regulatory and legal aspects that need to be considered when such products are intended to be used in a health care setting. Based on this brief overview, the article elaborates on the specific requirements in the main areas of authorization/certification and reimbursement/compensation, as well as data protection and data security. Three case studies are presented as examples of specific market access procedures: the USA, Germany, and Belgium. This article concludes that, despite the differences in specific requirements, market access pathways in most countries are characterized by a number of similarities, which should be considered early on in product development. The article also elaborates on how regulatory and legal requirements are currently being adapted for digitally driven wearables and proposes an ongoing evolution of these requirements to facilitate market access for beneficial medical technology in the future.
Ground-based solar observations are severely affected by Earth's turbulent atmosphere. As a consequence, observed image quality and prevailing seeing conditions are closely related. Partial correction of image degradation is nowadays provided in real time by adaptive optics (AO) systems. In this study, different metrics of image quality are compared with parameters characterizing the prevailing seeing conditions, i.e. Median Filter Gradient Similarity (MFGS), Median Filter Laplacian Similarity (MFLS), Helmli-Scherer mean, granular rms-contrast, differential image motion, and Fried-parameter r(0). The quiet-Sun observations at disk center were carried out at the Vacuum Tower Telescope (VTT), Observatorio del Teide (OT), Izana, Tenerife, Spain. In July and August 2016, time series of short-exposure images were recorded with the High-resolution Fast Imager (HiFI) at various wavelengths in the visible and near-infrared parts of the spectrum. Correlation analysis yields the wavelength dependence of the image quality metrics and seeing parameters, and Uniform Manifold Approximation and Projection (UMAP) is employed to characterize the seeing on a particular observing day. In addition, the image quality metrics and seeing parameters are used to determine the field dependence of the correction provided by the AO system. Management of high-resolution imaging data from large-aperture, ground-based telescopes demands reliable image quality metrics and meaningful characterization of prevailing seeing conditions and AO performance. The present study offers guidance on how retrieving such information ex post facto.