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The two and k-sample tests of equality of the survival distributions against the alternatives including cross-effects of survival functions, proportional and monotone hazard ratios, are given for the right censored data. The asymptotic power against approaching alternatives is investigated. The tests are applied to the well known chemio and radio therapy data of the Gastrointestinal Tumor Study Group. The P-values for both proposed tests are much smaller then in the case of other known tests. Differently from the test of Stablein and Koutrouvelis the new tests can be applied not only for singly but also to randomly censored data.
We consider a nonparametric survival model with random censoring. To test whether the hazard rate has a parametric form the unknown hazard rate is estimated by a kernel estimator. Based on a limit theorem stating the asymptotic normality of the quadratic distance of this estimator from the smoothed hypothesis an asymptotic ®-test is proposed. Since the test statistic depends on the maximum likelihood estimator for the unknown parameter in the hypothetical model properties of this parameter estimator are investigated. Power considerations complete the approach.
The dependence between survival times and covariates is described e.g. by proportional hazard models. We consider partly parametric Cox models and discuss here the estimation of interesting parameters. We represent the ma- ximum likelihood approach and extend the results of Huang (1999) from linear to nonlinear parameters. Then we investigate the least squares esti- mation and formulate conditions for the a.s. boundedness and consistency of these estimators.
We give a survey on procedures for testing functions which are based on quadratic deviation measures. The following problems are considered: Testing whether a density function lies in a parametric class of functions, whether continuous random variables are independent; testing cell probabilities and independence in sparse data sets; testing the parametric fit of a regression homoscedasticity in a regression model and testing the hazard rate in survival models with censoring and with and without covariates.
On a method for solution of the ordinary differential equations connected with Huygens' equations
(2010)
We construct elliptic elements in the algebra of (classical pseudo-differential) operators on a manifold M with conical singularities. The ellipticity of any such operator A refers to a pair of principal symbols (σ0, σ1) where σ0 is the standard (degenerate) homogeneous principal symbol, and σ1 is the so-called conormal symbol, depending on the complex Mellin covariable z. The conormal symbol, responsible for the conical singularity, is operator-valued and acts in Sobolev spaces on the base X of the cone. The σ1-ellipticity is a bijectivity condition for all z of real part (n + 1)/2 − γ, n = dimX, for some weight γ. In general, we have to rule out a discrete set of exceptional weights that depends on A. We show that for every operator A which is elliptic with respect to σ0, and for any real weight γ there is a smoothing Mellin operator F in the cone algebra such that A + F is elliptic including σ1. Moreover, we apply the results to ellipticity and index of (operator-valued) edge symbols from the calculus on manifolds with edges.
The Cauchy problem of the vacuum Einstein's equations aims to find a semimetric g(αβ) of a spacetime with vanishing Ricci curvature Rα,β and prescribed initial data. Under the harmonic gauge condition, the equations Rα,β = 0 are transferred into a system of quasi-linear wave equations which are called the reduced Einstein equations. The initial data for Einstein's equations are a proper Riemannian metric h(αβ) and a second fundamental form K(αβ). A necessary condition for the reduced Einstein equation to satisfy the vacuum equations is that the initial data satisfy Einstein constraint equations. Hence the data (h(αβ),K(αβ)) cannot serve as initial data for the reduced Einstein equations. Previous results in the case of asymptotically flat spacetimes provide a solution to the constraint equations in one type of Sobolev spaces, while initial data for the evolution equations belong to a different type of Sobolev spaces. The goal of our work is to resolve this incompatibility and to show that under the harmonic gauge the vacuum Einstein equations are well-posed in one type of Sobolev spaces.
We give a survey on the calculus of (pseudo-differential) boundary value problems with the transmision property at the boundary, and ellipticity in the Shapiro-Lopatinskij sense. Apart from the original results of the work of Boutet de Monvel we present an approach based on the ideas of the edge calculus. In a final section we introduce symbols with the anti-transmission property.
We give a brief survey on some new developments on elliptic operators on manifolds with polyhedral singularities. The material essentially corresponds to a talk given by the author during the Conference “Elliptic and Hyperbolic Equations on Singular Spaces”, October 27 - 31, 2008, at the MSRI, University of Berkeley.
We prove a local in time existence and uniqueness theorem of classical solutions of the coupled Einstein{Euler system, and therefore establish the well posedness of this system. We use the condition that the energy density might vanish or tends to zero at infinity and that the pressure is a certain function of the energy density, conditions which are used to describe simplified stellar models. In order to achieve our goals we are enforced, by the complexity of the problem, to deal with these equations in a new type of weighted Sobolev spaces of fractional order. Beside their construction, we develop tools for PDEs and techniques for hyperbolic and elliptic equations in these spaces. The well posedness is obtained in these spaces.
We consider a mixed problem for a degenerate differentialoperator equation of higher order. We establish some embedding theorems in weighted Sobolev spaces and show existence and uniqueness of the generalized solution of this problem. We also give a description of the spectrum for the corresponding operator.
The ellipticity of boundary value problems on a smooth manifold with boundary relies on a two-component principal symbolic structure (σψ; σ∂), consisting of interior and boundary symbols. In the case of a smooth edge on manifolds with boundary we have a third symbolic component, namely the edge symbol σ∧, referring to extra conditions on the edge, analogously as boundary conditions. Apart from such conditions in integral form' there may exist singular trace conditions, investigated in [6] on closed' manifolds with edge. Here we concentrate on the phenomena in combination with boundary conditions and edge problem.
We establish elements of a new approch to ellipticity and parametrices within operator algebras on a manifold with higher singularities, only based on some general axiomatic requirements on parameter-dependent operators in suitable scales of spaces. The idea is to model an iterative process with new generations of parameter-dependent operator theories, together with new scales of spaces that satisfy analogous requirements as the original ones, now on a corresponding higher level. The “full” calculus is voluminous; so we content ourselves here with some typical aspects such as symbols in terms of order reducing families, classes of relevant examples, and operators near the conical exit to infinity.
In this article we construct the fundamental solutions for the wave equation arising in the de Sitter model of the universe. We use the fundamental solutions to represent solutions of the Cauchy problem and to prove the Lp − Lq-decay estimates for the solutions of the equation with and without a source term.
We study the asymptotic regularity of solutions of Hartree-Fock equations for Coulomb systems. In order to deal with singular Coulomb potentials, Fock operators are discussed within the calculus of pseudo-differential operators on conical manifolds. First, the non-self-consistent-field case is considered which means that the functions that enter into the nonlinear terms are not the eigenfunctions of the Fock operator itself. We introduce asymptotic regularity conditions on the functions that build up the Fock operator which guarantee ellipticity for the local part of the Fock operator on the open stretched cone R+ × S². This proves existence of a parametrix with a corresponding smoothing remainder from which it follows, via a bootstrap argument, that the eigenfunctions of the Fock operator again satisfy asymptotic regularity conditions. Using a fixed-point approach based on Cances and Le Bris analysis of the level-shifting algorithm, we show via another bootstrap argument, that the corresponding self-consistent-field solutions of the Hartree-Fock equation have the same type of asymptotic regularity.
In this paper, we discuss the global existence of solutions for Chemotaxis models with saturation growth. If the coe±cients of the equations are all positive smooth T-periodic functions, then the problem has a positive T-periodic solution, and meanwhile we discuss here the stability problems for the T-periodic solutions.
Formal Poincaré lemma
(2007)
We show how the multiple application of the formal Cauchy-Kovalevskaya theorem leads to the main result of the formal theory of overdetermined systems of partial differential equations. Namely, any sufficiently regular system Au = f with smooth coefficients on an open set U ⊂ Rn admits a solution in smooth sections of a bundle of formal power series, provided that f satisfies a compatibility condition in U.
Contents: Part I: Symplectic Geometry Chapter 1: Symplectic Spaces and Lagrangian Planes Chapter 2: The Symplectic Group Chapter 3: Multi-Oriented Symplectic Geometry Chapter 4: Intersection Indices in Lag(n) and Sp(n) Part II: Heisenberg Group, Weyl Calculus, and Metaplectic Representation Chapter 5: Lagrangian Manifolds and Quantization Chapter 6: Heisenberg Group and Weyl Operators Chapter 7: The Metaplectic Group Part III: Quantum Mechanics in Phase Space Chapter 8: The Uncertainty Principle Chapter 9: The Density Operator Chapter 10: A Phase Space Weyl Calculus
Differential and pseudo-differential operators on a manifold with (regular) geometric singularities can be studied within a calculus, inspired by the concept of classical pseudo-differential operators on a C1 manifold. In the singular case the operators form an algebra with a principal symbolic hierarchy σ = (σj)0≤j≤k, with k being the order of the singularity and σk operator-valued for k ≥ 1. The symbols determine ellipticity and the nature of parametrices. It is typical in this theory that, similarly as in boundary value problems (which are special edge problems, where the edge is just the boundary), there are trace, potential and Green operators, associated with the various strata of the configuration. The operators, obtained from the symbols by various quantisations, act in weighted distribution spaces with multiple weights. We outline some essential elements of this calculus, give examples and also comment on new challenges and interesting problems of the recent development.
We develop an approach to the problem of optimal recovery of continuous linear functionals in Banach spaces through information on a finite number of given functionals. The results obtained are applied to the problem of the best analytic continuation from a finite set in the complex space Cn, n ≥ 1, for classes of entire functions of exponential type which belong to the space Lp, 1 < p < 1, on the real subspace of Cn. These latter are known as Wiener classes.
On a manifold with edge we construct a specific class of (edgedegenerate) elliptic differential operators. The ellipticity refers to the principal symbolic structure σ = (σψ, σ^) of the edge calculus consisting of the interior and edge symbol, denoted by σψ and σ^, respectively. For our choice of weights the ellipticity will not require additional edge conditions of trace or potential type, and the operators will induce isomorphisms between the respective edge spaces.
We prove the existence of a class of local in time solutions, including static solutions, of the Einstein-Euler system. This result is the relativistic generalisation of a similar result for the Euler-Poisson system obtained by Gamblin [8]. As in his case the initial data of the density do not have compact support but fall off at infinity in an appropriate manner. An essential tool in our approach is the construction and use of weighted Sobolev spaces of fractional order. Moreover, these new spaces allow us to improve the regularity conditions for the solutions of evolution equations. The details of this construction, the properties of these spaces and results on elliptic and hyperbolic equations will be presented in a forthcoming article.
We give a construction of an eigenstate for a non-critical level of the Hamiltonian function, and investigate the contribution of Morse critical points to the spectral decomposition. We compare the rigorous result with the series obtained by a perturbation theory. As an example the relation to the spectral asymptotics is discussed.
On null quadrature domains
(2006)
The characterization of null quadrature domains in Rn (n ≥ 3) has been an open problem throughout the past two and a half decades. A substantial contribution was done by Friedman and Sakai [10]; they showed that if the complement is bounded, then null quadrature domains are exactly the complement of ellip- soids. The first result with unbounded complements appeared in [15], there it is assumed the complement is contained in an infinitely cylinder. The aim of this paper is to show the relation between null quadrature domains and Newton's theorem on the gravitational force induced by homogeneous homoeoidal ellipsoids. We also succeed to make progress in the classification problem and we show that if the boundary of null quadrature domain is contained in a strip and the complement satisfies a certain capacity condition at infinity, then it must be a half-space or a complement of a strip. In addition, we present a Phragm¶en-Lindelöf type theorem which seems to be forgotten in the literature.
It is shown that an elliptic scattering operator A on a compact manifold with boundary with operator valued coefficients in the morphisms of a bundle of Banach spaces of class (HT ) and Pisier’s property (α) has maximal regularity (up to a spectral shift), provided that the spectrum of the principal symbol of A on the scattering cotangent bundle avoids the right half-plane. This is accomplished by representing the resolvent in terms of pseudodifferential operators with R-bounded symbols, yielding by an iteration argument the R-boundedness of λ(A − λ)−1 in R(λ)≥ τ for some τ ∈ IR. To this end, elements of a symbolic and operator calculus of pseudodifferential operators with R-bounded symbols are introduced. The significance of this method for proving maximal regularity results for partial differential operators is underscored by considering also a more elementary situation of anisotropic elliptic operators on Rd with operator valued coefficients.
We consider quasicomplexes of Boutet de Monvel operators in Sobolev spaces on a smooth compact manifold with boundary. To each quasicomplex we associate two complexes of symbols. One complex is defined on the cotangent bundle of the manifold and the other on that of the boundary. The quasicomplex is elliptic if these symbol complexes are exact away from the zero sections. We prove that elliptic quasicomplexes are Fredholm. As a consequence of this result we deduce that a compatibility complex for an overdetermined elliptic boundary problem operator is also Fredholm. Moreover, we introduce the Euler characteristic for elliptic quasicomplexes of Boutet de Monvel operators.
By quasicomplexes are usually meant perturbations of complexes small in some sense. Of interest are not only perturbations within the category of complexes but also those going beyond this category. A sequence perturbed in this way is no longer a complex, and so it bears no cohomology. We show how to introduce Euler characteristic for small perturbations of Fredholm complexes. The paper is to appear in Funct. Anal. and its Appl., 2006.
We study elliptic boundary value problems in a wedge with additional edge conditions of trace and potential type. We compute the (difference of the) number of such conditions in terms of the Fredholm index of the principal edge symbol. The task will be reduced to the case of special opening angles, together with a homotopy argument.
We study the Cauchy problem for the oscillation equation of the couple-stress theory of elasticity in a bounded domain in R3. Both the displacement and stress are given on a part S of the boundary of the domain. This problem is densely solvable while data of compact support in the interior of S fail to belong to the range of the problem. Hence the problem is ill-posed which makes the standard calculi of Fourier integral operators inapplicable. If S is real analytic the Cauchy-Kovalevskaya theorem applies to guarantee the existence of a local solution. We invoke the special structure of the oscillation equation to derive explicit conditions of global solvability and an approximation solution.
We establish a new calculus of pseudodifferential operators on a manifold with smooth edges and study ellipticity with extra trace and potential conditions (as well as Green operators) at the edge. In contrast to the known scenario with conditions of that kind in integral form we admit in this paper ‘singular’ trace, potential and Green operators, which are related to the corresponding operators of positive type in Boutet de Monvel’s calculus for boundary value problems.
In order to characterise the C*-algebra generated by the singular Bochner-Martinelli integral over a smooth closed hypersurfaces in Cn, we compute its principal symbol. We show then that the Szegö projection belongs to the strong closure of the algebra generated by the singular Bochner-Martinelli integral.
Contents: 1 The main notations and definitions. 2 Statement of the problems and main results. 2.1 The case of a Z-configuration. 2.2 The case of a P-configuration. 3 Proofs of Theorems 1-7. 4 Applications. 4.1 Multiplicative Cauchy type functional equation. 4.2 On some integral equations relating to a geometric problem 4.3 On the solvability of boundary problem for hyperbolic differential equations.
For elliptic systems of differential equations on a manifold with boundary, we prove the Fredholm property of a class of boundary problems which do not satisfy the Shapiro-Lopatinskii property. We name these boundary problems generalised elliptic, for they preserve the main properties of elliptic boundary problems. Moreover, they reduce to systems of pseudodifferential operators on the boundary which are generalised elliptic in the sense of Saks (1997).
We construct a special asymptotic solution for the forced KdV equation. In the frame of the shallow water model this kind of the external driving force is related to the atmospheric disturbance. The perturbation slowly passes through a resonance and it leads to the solution exchange. The detailed asymptotic description of the process is presented.
Operators on a manifold with (geometric) singularities are degenerate in a natural way. They have a principal symbolic structure with contributions from the different strata of the configuration. We study the calculus of such operators on the level of edge symbols of second generation, based on specific quantizations of the corner-degenerate interior symbols, and show that this structure is preserved under compositions.
The aim of this paper is to explain the notion of subspace defined by means of pseudodifferential projection and give its applications in elliptic theory. Such subspaces are indispensable in the theory of well-posed boundary value problems for an arbitrary elliptic operator, including the Dirac operator, which has no classical boundary value problems. Pseudodifferential subspaces can be used to compute the fractional part of the spectral Atiyah–Patodi–Singer eta invariant, when it defines a homotopy invariant (Gilkey’s problem). Finally, we explain how pseudodifferential subspaces can be used to give an analytic realization of the topological K-group with finite coefficients in terms of elliptic operators. It turns out that all three applications are based on a theory of elliptic operators on closed manifolds acting in subspaces.