Refine
Has Fulltext
- yes (105) (remove)
Year of publication
- 2012 (105) (remove)
Document Type
- Doctoral Thesis (105) (remove)
Language
- English (66)
- German (38)
- Multiple languages (1)
Keywords
- Korrosion (3)
- Nanopartikel (3)
- corrosion (3)
- Blickbewegungen (2)
- Computationale Modellierung (2)
- Evaluation (2)
- Fernerkundung (2)
- Fluoreszenzmikroskopie (2)
- Klimawandel (2)
- Lake sediments (2)
- Machine Learning (2)
- Magnetismus (2)
- Maschinelles Lernen (2)
- Mikrotubuli (2)
- Organisationstheorie (2)
- Parasit (2)
- Quantenpunkte (2)
- climate change (2)
- computational modeling (2)
- evaluation (2)
- fluorescence microscopy (2)
- nanoparticles (2)
- quantum dots (2)
- remote sensing (2)
- stochastic processes (2)
- stochastische Prozesse (2)
- AC -Impedance (1)
- AC Impedanz (1)
- ATP hydrolysis (1)
- ATP-Hydrolyse (1)
- ATRP (1)
- Abbau (1)
- Abbau von Boten-RNS (1)
- Abstandsverteilungen (1)
- Active Evaluation (1)
- Adhesion (1)
- Adhäsion (1)
- Adsorption (1)
- Adversarial Learning (1)
- Aerogele (1)
- Aerogels (1)
- Africa (1)
- Afrika (1)
- Agglomerate (1)
- Aggregates (1)
- Aggressivität (1)
- Agonisteninteraktion (1)
- Aktinfilamente (1)
- Aktionsraum (1)
- Aktive Evaluierung (1)
- Allometrie (1)
- Aluminiumlegierung (1)
- Amphiphile Polymere (1)
- Angewandte Spieltheorie (1)
- Anisotrope Inversion (1)
- Anisotropie der Leitfähigkeit (1)
- Anpassung (1)
- Anrege-Abtast Spektroskopie (1)
- Antireduktionismus (1)
- Apodemus (1)
- Apollo (1)
- Applied Game Theory (1)
- Aquifer (1)
- Arbuskuläre Mykorrhiza (1)
- Arctic (1)
- Arktis (1)
- Artengemeinschaft (1)
- Assoziative Verdicker (1)
- Athlet (1)
- Atom Transfer Radical Polymerization (1)
- Atom-Chips (1)
- Atom-Oberflächenwechselwirkung (1)
- Atrophin-1 (1)
- Aufstiegsmobilität (1)
- Augmented Reality (1)
- BLUF (1)
- Bayes-Entscheidungstheorie (1)
- Bayesian inference (1)
- Bayesian statistical decision theory (1)
- Bayessche Statistik (1)
- Behavior (1)
- Berlin (1)
- Beschichtungen (1)
- Beta-Zelle (1)
- Betulin (1)
- Bewegung (1)
- Bi2Se3 (1)
- Bi2Te3 (1)
- Bioconjugation (1)
- Biofilme (1)
- Bioinformatik (1)
- Biokonjugation (1)
- Biomass (1)
- Biomasse (1)
- Biosensor (1)
- Bittergeschmack (1)
- Blattalterung (1)
- Blockcopolymere (1)
- Bodenfeuchte (1)
- CESA Komplex (1)
- CXCL10 (1)
- Calliphora (1)
- Carbon materials (1)
- Case study (1)
- Centrosom (1)
- Centrosome (1)
- Channel Transmission Losses (1)
- Channeling (1)
- Chaos (1)
- Chelate (1)
- Chiroptera (1)
- Chlamydomonas (1)
- Chloroplast (1)
- Click Chemistry (1)
- Click chemistry (1)
- Climate change (1)
- Climate reconstruction (1)
- Cluster Entwicklung (1)
- Cluster expansion (1)
- Co-Evolution (1)
- Cokultur (1)
- Collagenase (1)
- Composition (1)
- Copolymere (1)
- Copper Phthalocyanine (1)
- DDR (1)
- DNA (1)
- DNA Ejektion (1)
- DNA ejection (1)
- DRB Evolution (1)
- DRB evolution (1)
- Datenanalyse (1)
- Datenverwendung (1)
- Degradation (1)
- Degradation of messenger RNA (1)
- Degradom (1)
- Delomys (1)
- Depolymerisation (1)
- Determinantal point processes (1)
- Deutschland (1)
- Diabetes (1)
- Dictyostelium (1)
- Dielektrische Funktion (1)
- Diffusion (1)
- Dionysos (1)
- Dirac-harmonic maps (1)
- Dirac-harmonische Abbildungen (1)
- Dryland Rivers (1)
- Dualitätsformeln (1)
- Effektheterogenität (1)
- Einkapselung (1)
- Elastizitätsmodul (1)
- Electric power production (1)
- Electrocatalysis (1)
- Elektrizitätsmarkt (1)
- Elektrokatalyse (1)
- Emissionshandel (1)
- Enegieanwendungen (1)
- Energieausbreitung (1)
- Energy Applications (1)
- Entwicklungsländer (1)
- Entzündung (1)
- Error Estimation (1)
- Erweiterte Realität (1)
- Erziehung (1)
- Erziehungsheim (1)
- Essstörung (1)
- Evaluationsfunktion (1)
- Excellence (1)
- Eye movements (1)
- Eyring-Kramers Formel (1)
- FRET (1)
- Fallstudie (1)
- Fehlerschätzung (1)
- Fest-Flüssig-Extraktion (1)
- Festelektrolyten (1)
- Festkörperphysik (1)
- Fibroblasten (1)
- Finsler geometry (1)
- Fixationdauern (1)
- Fixationspositionen (1)
- Fixationssequenzen (1)
- Fledermäuse (1)
- Flood Forecasting (1)
- Flüssig-Flüssig-Extraktion (1)
- Folgenabschätzung (1)
- Formgedächtnispolymere (1)
- Forschungsdatenzentrum (1)
- Fortpflanzung (1)
- Frequenz (1)
- Functionalization (1)
- Funktionalisierung (1)
- Fusarium (1)
- Fußgängernavigation (1)
- G-protein-coupled receptors (1)
- GDR (1)
- GIS (1)
- GPCR (1)
- Gaspermeation (1)
- Gaylussite (1)
- Gebäudemodelle (1)
- Gedankenschweifen (1)
- Gedankenverlorenes Lesen (1)
- Gelatin (1)
- Gelatine (1)
- Geländemodelle (1)
- Generalisierung (1)
- Genexpression (1)
- Germany (1)
- Geschmack (1)
- Gesundheitswesen (1)
- Gibbs point processes (1)
- Gibbssche Punktprozesse (1)
- Glucolipotoxizität (1)
- Gold (1)
- Gradient flow (1)
- Gradientenfluss (1)
- Gravitationswellen (1)
- Green Chemistry (1)
- Grüne Chemie (1)
- Gute-Gene (1)
- HHH Theorien (1)
- Hanoi (1)
- Harnstoff-Glas-Route (1)
- Haushalt (1)
- Health Care (1)
- Heat Flow (1)
- Hemisphärenunterschiede (1)
- Hermeneutik (1)
- Heteroatom Doping (1)
- Heteroatom-Dotierung (1)
- Heteroatom-dotierte Kohlenstoffe (1)
- Higher education (1)
- Hochleistungssport (1)
- Hochschulbildung (1)
- Hochwasservorhersage (1)
- Hohlkugeln (1)
- Hollow Spheres (1)
- Homologiemodellierung (1)
- Household (1)
- Hurst exponent (1)
- Hurst-Exponent (1)
- Hyaluronic acid (1)
- Hyaluronsäure (1)
- Hydrodynamik (1)
- Hydrological Modelling (1)
- Hydrological extremes (1)
- Hydrophilie (1)
- Hydrothermal Carbonization (1)
- Hydrothermale Karbonisierung (1)
- Identifizierung berühmter Personen (1)
- Indian summer monsoon (1)
- Indische Sommer Monsun (1)
- Individuen (1)
- Inflammation (1)
- Institution (1)
- Inszenierung (1)
- Intergalaktisches Medium (1)
- Intimahyperplasie (1)
- Intimal Hyperplasia (1)
- Investments environmental aspects (1)
- Jahresabschlussanalyse (1)
- Jugend (1)
- Jugendalter (1)
- Keimbildung und Wachstum (1)
- Keratinozyten (1)
- Kerndynamik (1)
- Klick-Chemie (1)
- Klickchemie (1)
- Klimarekonstruktion (1)
- Kohlenhydrat Erkennung (1)
- Kohlenmaterialien (1)
- Kollagenase (1)
- Kommunikation (1)
- Kompetenzentwicklung (1)
- Komposition (1)
- Konfliktgeschichte (1)
- Korruption (1)
- Kosmologie (1)
- Kultur (1)
- Kupferphthalocyanin (1)
- LCST (1)
- Ladungstransport (1)
- Land Reform (1)
- Land use change (1)
- Landmarken (1)
- Landnutzung (1)
- Landwirtschaft (1)
- Lanthanoidkomplexe (1)
- Leaf senescence (1)
- Learning interaction (1)
- Lehrergesundheit (1)
- Lehrertraining (1)
- Lern-Interaktion (1)
- Levels-of-inattention Hypothese (1)
- Levy Maß (1)
- Levy measure (1)
- Li-Batterien (1)
- Li-batteries (1)
- Liberalisierung (1)
- Ligandendesign (1)
- Lithium ion battery (1)
- Lithium-Ionen-Batterie (1)
- Lonar lake (1)
- Lonarsee (1)
- MHC (1)
- MHC Klasse II (1)
- MHC polymorphism (1)
- Machtkampf (1)
- Magnetisierungsdynamik (1)
- Magnetotellurik (1)
- Management (1)
- Medicago truncatula (1)
- Megamodel (1)
- Megamodell (1)
- Metabolische Netzwerke (1)
- Metacognitive strategies (1)
- Metakognitionsstrategien (1)
- Metallnitrid-Kohlenstoff Komposite (1)
- Metastabilität (1)
- Microorganisms (1)
- Microtubules (1)
- Mikroorganismen (1)
- Mikroökonometrie (1)
- Ministerial bureaucracy (1)
- Ministerialverwaltung (1)
- Mitose (1)
- Mitosis (1)
- Model Management (1)
- Model-Driven Engineering (1)
- Modeling (1)
- Modell (1)
- Modell Management (1)
- Modellgetriebene Entwicklung (1)
- Modellierung (1)
- Modifizierung von Polymeren (1)
- Molecular Aging (1)
- Molekulares Altern (1)
- Mondsee (1)
- Morphologie von Kapseln (1)
- Musikinstrumente (1)
- Mycorrhiza (1)
- Mycorrhizal symbiosis (1)
- Mykorrhiza (1)
- Mykorrhizasymbiose (1)
- Mykotoxine (1)
- Mythos (1)
- NZO (1)
- Nachhaltigkeit (1)
- Nano (1)
- Nanostruktur (1)
- Nanostäbchen (1)
- Nanotechnologie (1)
- Narziss (1)
- Naturstoff (1)
- Navigation (1)
- Neointima (1)
- Netzwerke (1)
- Neue Kulturgeographie (1)
- Neuoffenbarungen (1)
- New Revelations (1)
- Nichtexponentieller Zerfall von mRNA (1)
- Nitride (1)
- Nitrides (1)
- Noctilio albiventris (1)
- Non-exponential mRNA decay (1)
- Nucleus (1)
- Nullmodell (1)
- Numerische Relativitätstheorie (1)
- OFET (1)
- Oberflächen (1)
- Oberflächenfunktionalisierung (1)
- Oberflächenladung (1)
- Oberflächenplasmonenlasmonen (1)
- Oberflächenzustände (1)
- Organic Solar Cell (1)
- Organisationslernen (1)
- Organische Solarzellen (1)
- Organization theory (1)
- Oxinitride (1)
- Oxynitrides (1)
- Paleofloods (1)
- Palladium (1)
- Paläohochwasser (1)
- Parasite (1)
- Parasiten (1)
- Parasites (1)
- Partei (1)
- Partizipation (1)
- Performance (1)
- Performance Management (1)
- Performance-Informationen (1)
- Pflanzenwachstum (1)
- Phage HK620 (1)
- Phagen Infektion (1)
- Phononen (1)
- Phonotaktik (1)
- Phosphat (1)
- Photoanregung (1)
- Photoexcitation (1)
- Plastome-evolution (1)
- Plastomevolution (1)
- Platzierung (1)
- Polarimetrie (1)
- Polarimetry (1)
- Policy advice (1)
- Politikberatung (1)
- Polyelektrolyte (1)
- Polyeste r (1)
- Polymer Modification (1)
- Polysaccharide (1)
- Poröse Materialien (1)
- Post-Newton (1)
- Post-transcriptional gene regulation (1)
- Posttranskriptionale Genregulation (1)
- Prediction Game (1)
- Predictive Models (1)
- Prime Minister's Office (1)
- Private Revelations (1)
- Privatoffenbarungen (1)
- Process (1)
- Promotor (1)
- Prophecy (1)
- Prophetie (1)
- Prostatakrebs (1)
- Protein Spektroelektrochemie (1)
- Protein spectroelectrochemistry (1)
- Protein-Kohlenhydrat-Interaktion (1)
- Proteinaggregation (1)
- Proteinmissfaltung (1)
- Prozesse (1)
- Prädiktionsspiel (1)
- Quality (1)
- Qualität (1)
- Quanten Optomechanik (1)
- Quantencomputer (1)
- Quantenfluktuationen (1)
- Quantenoptik (1)
- Quantum Optomechanics (1)
- Quantum dynamics (1)
- RAFT (1)
- RAFT polymerisation (1)
- RAFT-Polymerisation (1)
- RNAi (1)
- Randomisierung (1)
- Rasterkraftmikroskop (1)
- Reactive Oxygen Species (1)
- Reaktive Sauerstoffspezies (1)
- Rechenschaftspflicht (1)
- Rechtsstaatlichkeit (1)
- Regierungszentrale (1)
- Regularisierung (1)
- Regulationsweg (1)
- Rekonfiguration (1)
- Relativismus (1)
- Resistenzmechanismen (1)
- Resonator Quantenelektrodynamik (1)
- Rezeptor (1)
- Riboflavin (1)
- Ring (1)
- Ringe (1)
- Rotationsbeschichtung (1)
- Röntgenspektroskopie (1)
- SAR (1)
- STM (1)
- Salmonella (1)
- Salts (1)
- Salze (1)
- Saturn (1)
- Savanna (1)
- Savanne (1)
- Schul- und Unterrichtsentwicklung (1)
- Schwarze Löcher (1)
- Schwefel-Ligand (1)
- Seesediment (1)
- Seesedimente (1)
- Sektor Staat (1)
- Selbst- und Fremdeinschätzung (1)
- Selbstheilende Beschichtungen (1)
- Selbstorganisation (1)
- Selbstregulation (1)
- Semiklassische Spektralasymptotik (1)
- Sequenzierung (1)
- Serotonin (1)
- Signifikanz (1)
- Silika (1)
- Social Structure (1)
- Social Unequality (1)
- Social networking software (1)
- Sozial Vernetzung Software (1)
- Soziale Ungleichheit (1)
- Sozialstruktur (1)
- Spam Filtering (1)
- Spam-Filter (1)
- Spin Geometrie (1)
- Spin Geometry (1)
- Spin casting (1)
- Spinpolarisation (1)
- Spiritism (1)
- Spiritismus (1)
- Spiti valley (1)
- Spity Valley (1)
- Sportler (1)
- Sprache (1)
- Spracherwerb (1)
- Spracherwerbsstörung (1)
- Sprachphilosophie (1)
- Statistical Tests (1)
- Statistik öffentlicher Unternehmen (1)
- Statistische Tests (1)
- Sternpolymere (1)
- Stimmenverarbeitung (1)
- Stochastic gene expression (1)
- Stochastische Genexpression (1)
- Strahlenbiologie (1)
- Streuung von Schallwellen (1)
- Structuring (1)
- Strukturelle Thermodynamik (1)
- Strukturierung (1)
- Städtebauförderung (1)
- Subsilbe (1)
- Sulfitoxidase (1)
- Superkondensator (1)
- Sustainability (1)
- Synthese (1)
- Systemtheorie (1)
- Tailspike (1)
- Tailspike Protein (1)
- Teilhabe der BürgerInnen (1)
- Thermalisierung (1)
- Thiophen und Benzodithiophen Copolymere (1)
- Thiophene and Benzodithiophene copolymers (1)
- Traceability (1)
- Trainingsevaluation (1)
- Transferverluste in Flüssen (1)
- Transkriptionsfaktor (1)
- Transkriptom (1)
- Transparenz (1)
- Trockenflüsse (1)
- Tunneleffekt (1)
- Ultraschnelle Dynamik (1)
- Uncertainty Analysis (1)
- Unsicherheitsanalyse (1)
- Upward Mobility (1)
- Urea-Glas-Route (1)
- Van der Waals Kräfte (1)
- Van der Waals forces (1)
- Verbflexion (1)
- Verhalten (1)
- Verschränkung (1)
- Vibronik (1)
- Vielteilchentheorie (1)
- Vorhersagemodelle (1)
- Warven (1)
- Warves (1)
- Water resources (1)
- Web 2.0 (1)
- Weizen (1)
- Well-structuredness (1)
- Wigner Funktion (1)
- Wigner negativity (1)
- Wiki (1)
- Wohlstrukturiertheit (1)
- Wärmefluss (1)
- Xanthindehydrogenase (1)
- Zellkern (1)
- Zellwand (1)
- Zieleffektivitätstraining (1)
- Zirkulardichroismus (1)
- Zytoskelett (1)
- Zählprozesse (1)
- [2+2]-Cycloaddition (1)
- [2+2]-cycloaddition (1)
- ab-initio Dynamik (1)
- ab-initio dynamics (1)
- actin filaments (1)
- active labor market policy (1)
- active polymers (1)
- adapation (1)
- adolescent (1)
- aggregation (1)
- aggressiveness (1)
- agonists interaction (1)
- agriculture (1)
- aktive Arbeitsmarktpolitik (1)
- aktive Polymere (1)
- allometry (1)
- aluminum alloy (1)
- amphiphilic polymers (1)
- angle resolved photoelectron spectroscopy (1)
- anisotropic inversion (1)
- anterior temporal lobes (1)
- anteriorer Temporallappen (1)
- antireductionism (1)
- arbuscular mycorrhiza (1)
- associative thickeners (1)
- atom chips (1)
- atom-surface interaction (1)
- atomic force microscope (1)
- atrophin-1 (1)
- augmented reality (1)
- bacterial O-antigen (1)
- bakterielles O-Antigen (1)
- beta-cell (1)
- biofilm (1)
- biosensor (1)
- bitter taste (1)
- black holes (1)
- block copolymers (1)
- building models (1)
- capsule morphology (1)
- carbohydrate interaction (1)
- carbohydrate recognition (1)
- cavity quantum electrodynamics (1)
- cell wall (1)
- cellular signalling (1)
- cesa complex (1)
- chaos (1)
- charge transfer (1)
- chelates (1)
- circular dichroism (1)
- climate dynamics (1)
- coating (1)
- coculture (1)
- communication (1)
- community (1)
- competence development (1)
- computational biology (1)
- conductivity anisotropy (1)
- conflict (1)
- conjugated small molecules (1)
- continental philosophy (1)
- cooperative transport (1)
- copolymers (1)
- cosmology (1)
- counting process (1)
- crop modeling (1)
- curriculum and lesson plan develop (1)
- cytoskeleton (1)
- data analysis (1)
- data use (1)
- degradome (1)
- depolymerization (1)
- determinantische Punktprozesse (1)
- developing countries (1)
- diabetes (1)
- dielectric function (1)
- diffusion (1)
- discrete Witten complex (1)
- diskreter Witten-Laplace-Operator (1)
- disordered eating (1)
- distance distribution (1)
- duality formulae (1)
- eating disorder (1)
- eco-hydrological modelling (1)
- ectoparasites (1)
- education (1)
- effect heterogeneity (1)
- elastic coupling (1)
- elastic modulus (1)
- elastische Kopplung (1)
- elite athlete (1)
- encapsulation (1)
- energy spreading (1)
- epitaktisch (1)
- epitaxial (1)
- eye movements (1)
- famous speaker recognition (1)
- fibroblasts (1)
- financial statement analysis (1)
- fixation durations (1)
- fixation positions (1)
- fixation sequences (1)
- fixational eye movements (1)
- fixierte Augenbewegungen (1)
- flüssigkristalline Netzwerke (1)
- formale Institution (1)
- fractional Brownian motion (1)
- fractional Gaussian noise (1)
- fraktionale Brown'schen Bewegung (1)
- fraktionales Gauß'sches Rauschen (1)
- frequency (1)
- function of evaluation (1)
- gas permeation (1)
- gene expression (1)
- generalization (1)
- genetic fingerprinting (1)
- genetisches Fingerprinting (1)
- geothermal aquifer (1)
- gequetschte Zustände (1)
- gestörtes Essverhalten (1)
- glucolipotoxicity (1)
- goal effectiveness training (1)
- gold (1)
- good governance (1)
- good-genes-model (1)
- gravitational waves (1)
- gute Regierungsführung (1)
- hTAS2R10 (1)
- hemispheric differences (1)
- hermeneutics (1)
- heteroatom-doped carbons (1)
- home range (1)
- homology modelling (1)
- human geography (1)
- hydrodynamics (1)
- hydrologische Modellierung (1)
- hydrophilicity (1)
- impact assessment (1)
- individual-based model (1)
- infinite divisibility (1)
- infinitely divisible point processes (1)
- informelle Institution (1)
- inscenation (1)
- intergalactic medium (1)
- intracellular transport (1)
- intrazellulärer Transport (1)
- ionic liquids (1)
- ionische Flüssigkeiten (1)
- keratinocytes (1)
- konjugierte kleine Moleküle (1)
- kontinentale Philosophie (1)
- kooperativer Transport (1)
- kulturell-kognitive Institution (1)
- lake sediments (1)
- land reform (1)
- land use (1)
- landmarks (1)
- langfristige Effekte (1)
- language acquisition (1)
- lanthanide complexes (1)
- learning organization (1)
- levels-of-inattention hypothesis (1)
- life history (1)
- ligand design (1)
- liquid-crystalline elastomers (1)
- local governance (1)
- long-term effects (1)
- low-lying eignvalues (1)
- magnetism (1)
- magnetization dynamics (1)
- magnetotelluric (1)
- mesoporous (1)
- mesoporös (1)
- metabolic networks (1)
- metal nitride carbon composites (1)
- metastability (1)
- miRNA (1)
- miRNAs (1)
- microRNA399 (1)
- microeconometrics (1)
- microporous polymers (1)
- microtubules (1)
- mikroRNA399 (1)
- mikroporöse Polymere (1)
- mind wandering (1)
- mindless reading (1)
- misfolding (1)
- modified dispersion relations (1)
- modified gravitational dynamics (1)
- molecular motors (1)
- molecular switches (1)
- molekulare Motoren (1)
- molekulare Schalter (1)
- multi-stimuli sensitiv materials (1)
- multi-stimuli sensitive Materialien (1)
- music instruments (1)
- mycotoxins (1)
- myth (1)
- nachhaltige Entwicklung (1)
- nachhaltige Landnutzung (1)
- nanorods (1)
- nanostructure (1)
- nanostructured materials (1)
- nanostrukturierte Materialien (1)
- nanotechnology (1)
- navigation (1)
- networks-on-chip (1)
- neuer Institutionalismus (1)
- next generation sequencing (1)
- nicht klassische Zustände (1)
- nichtlineare partielle Differentialgleichung (1)
- non-classicality (1)
- nonlinear partial differential equations (1)
- nucleation and growth (1)
- null model (1)
- numerical relativity (1)
- ob/ob (1)
- organic semiconductors (1)
- organische Halbleiter (1)
- organizational theory (1)
- paleofloods (1)
- palladium (1)
- pedestrian navigation (1)
- performance (1)
- performance information (1)
- performance management (1)
- periglacial landscapes (1)
- periglaziale Landschaften (1)
- phage HK620 (1)
- phage infection (1)
- philosophy of language (1)
- phonons (1)
- phonotactics (1)
- phosphate (1)
- piezoelectric sensors (1)
- piezoelektrische Sensoren (1)
- placement (1)
- polarimetric decompositions (1)
- polarimetrische Dekompositionen (1)
- political parties (1)
- political sociology (1)
- politische Soziologie (1)
- polyQ (1)
- polyelectrolytes (1)
- polyesters (1)
- polysaccharides (1)
- porous materials (1)
- post-Newton (1)
- power struggles (1)
- prostate cancer (1)
- public sector (1)
- pump-probe spectroscopy (1)
- quantization of field theories (1)
- quantum computer (1)
- quantum fluctuations (1)
- quantum many-body theory (1)
- quantum optics (1)
- quasiparticle interactions (1)
- radiation biology (1)
- randomization (1)
- reciprocal class (1)
- reconfiguration (1)
- refined spacetime geometries (1)
- regularization (1)
- regulative Institution (1)
- regulatory pathway (1)
- relativism (1)
- renewable resources (1)
- reproduction (1)
- rescaled lattice (1)
- research data centre (1)
- resistance mechanisms (1)
- reziproke Klassen (1)
- räumliche Analyse (1)
- salmonella (1)
- scheduling (1)
- schlechte Regierungsführung (1)
- selection (1)
- self-assembly (1)
- self-assessment and third-party assessment (1)
- self-healing coatings (1)
- self-regulation (1)
- semiclassical spectral asymptotics (1)
- serotonin (1)
- shape-memory polymers (1)
- significance (1)
- silica nanoparticles (1)
- soil moisture (1)
- solid phase extraction (1)
- solid state physics (1)
- solid-state-electrolyte (1)
- solvent extraction (1)
- sozialistische Orientierung der Marktwirtschaft (1)
- spatial analyses (1)
- specific language impairment (1)
- spectroscopic ruler (1)
- spektroskopisches Lineal (1)
- spin resolved photoelectron spectroscopy (1)
- spin-orbit coupling (1)
- spinaufgelöste Photoelektronenspektroskopie (1)
- sport (1)
- squeezing entanglement (1)
- star polymers (1)
- state-owned companies (1)
- statistics of the state-owned companies (1)
- stochastic mechanics (1)
- stochastische Mechanik (1)
- strengths-based intervention (1)
- structural thermodynamics (1)
- stärkenbasierte Intervention (1)
- subyllable (1)
- sulfite oxidase (1)
- sulfur ligands (1)
- supercapacitors (1)
- surface charge (1)
- surface chemistry (1)
- surface plasmons (1)
- surface states (1)
- surfaces (1)
- sustainable development (1)
- sustainable land use (1)
- symbiose-relevante mikroRNA-Targets (1)
- symbiosis-relevant microRNA targets (1)
- synthesis (1)
- system theory (1)
- tailspike (1)
- tailspike protein (1)
- taste (1)
- teacher training (1)
- teachers health (1)
- terrain models (1)
- thermalization (1)
- thermisch schaltbar (1)
- thermoresponsive (1)
- time reversal symmetry (1)
- topological insulators (1)
- topologische Isolatoren (1)
- training evaluation (1)
- transcription factor (1)
- transcriptomics (1)
- ultrafast dynamics (1)
- ultrafast x-ray diffraction (1)
- ultraschnelle Röntgenbeugung (1)
- unendlich teilbare Punktprozesse (1)
- unendliche Teilbarkeit (1)
- unique entities (1)
- urban development (1)
- varves (1)
- verb inflection (1)
- vibronics (1)
- virtual 3D city models (1)
- virtuelle 3D-Stadtmodelle (1)
- voice processing (1)
- wave scattering (1)
- wheat (1)
- winkelaufgelöste Photoelektronenspektroskopie (1)
- x-ray spectroscopy (1)
- xanthine dehydrogenase (1)
- youth (1)
- zelluläre Signalübertragung (1)
- Öffentliche Unternehmen (1)
- ökohydrologische Modellierung (1)
- Čechov (1)
- “Can do”-checklists (1)
- „Ich-kann“-Checklisten (1)
Institute
- Institut für Biochemie und Biologie (22)
- Institut für Chemie (19)
- Institut für Physik und Astronomie (18)
- Institut für Geowissenschaften (10)
- Extern (8)
- Institut für Informatik und Computational Science (6)
- Wirtschaftswissenschaften (5)
- Department Psychologie (4)
- Institut für Mathematik (4)
- Sozialwissenschaften (4)
- Hasso-Plattner-Institut für Digital Engineering gGmbH (3)
- Institut für Umweltwissenschaften und Geographie (3)
- Department Erziehungswissenschaft (2)
- Department Linguistik (2)
- Institut für Ernährungswissenschaft (2)
- Historisches Institut (1)
- Institut für Philosophie (1)
- Institut für Religionswissenschaft (1)
- Institut für Slavistik (1)
Carbohydrate recognition is a ubiquitous principle underlying many fundamental biological processes like fertilization, embryogenesis and viral infections. But how carbohydrate specificity and affinity induce a molecular event is not well understood. One of these examples is bacteriophage P22 that binds and infects three distinct Salmonella enterica (S.) hosts. It recognizes and depolymerizes repetitive carbohydrate structures of O antigen in its host´s outer membrane lipopolysaccharide molecule. This is mediated by tailspikes, mainly β helical appendages on phage P22 short non contractile tail apparatus (podovirus). The O antigen of all three Salmonella enterica hosts is built from tetrasaccharide repeating units consisting of an identical main chain with a distinguished 3,6 dideoxyhexose substituent that is crucial for P22 tailspike recognition: tyvelose in S. Enteritidis, abequose in S. Typhimurium and paratose in S. Paratyphi. In the first study the complexes of P22 tailspike with its host’s O antigen octasaccharide were characterized. S. Paratyphi octasaccharide binds less tightly (ΔΔG≈7 kJ/mol) to the tailspike than the other two hosts. Crystal structure analysis of P22 tailspike co crystallized with S. Paratyphi octasaccharides revealed different interactions than those observed before in tailspike complexes with S. Enteritidis and S. Typhimurium octasaccharides. These different interactions occur due to a structural rearrangement in the S. Paratyphi octasaccharide. It results in an unfavorable glycosidic bond Φ/Ψ angle combination that also had occurred when the S. Paratyphi octasaccharide conformation was analyzed in an aprotic environment. Contributions of individual protein surface contacts to binding affinity were analyzed showing that conserved structural waters mediate specific recognition of all three different Salmonella host O antigens. Although different O antigen structures possess distinct binding behavior on the tailspike surface, all are recognized and infected by phage P22. Hence, in a second study, binding measurements revealed that multivalent O antigen was able to bind with high avidity to P22 tailspike. Dissociation rates of the polymer were three times slower than for an octasaccharide fragment pointing towards high affinity for O antigen polysaccharide. Furthermore, when phage P22 was incubated with lipopolysaccharide aggregates before plating on S. Typhimurium cells, P22 infectivity became significantly reduced. Therefore, in a third study, the function of carbohydrate recognition on the infection process was characterized. It was shown that large S. Typhimurium lipopolysaccharide aggregates triggered DNA release from the phage capsid in vitro. This provides evidence that phage P22 does not use a second receptor on the Salmonella surface for infection. P22 tailspike binding and cleavage activity modulate DNA egress from the phage capsid. DNA release occurred more slowly when the phage possessed mutant tailspikes with less hydrolytic activity and was not induced if lipopolysaccharides contained tailspike shortened O antigen polymer. Furthermore, the onset of DNA release was delayed by tailspikes with reduced binding affinity. The results suggest a model for P22 infection induced by carbohydrate recognition: tailspikes position the phage on Salmonella enterica and their hydrolytic activity forces a central structural protein of the phage assembly, the plug protein, onto the host´s membrane surface. Upon membrane contact, a conformational change has to occur in the assembly to eject DNA and pilot proteins from the phage to establish infection. Earlier studies had investigated DNA ejection in vitro solely for viruses with long non contractile tails (siphovirus) recognizing protein receptors. Podovirus P22 in this work was therefore the first example for a short tailed phage with an LPS recognition organelle that can trigger DNA ejection in vitro. However, O antigen binding and cleaving tailspikes are widely distributed in the phage biosphere, for example in siphovirus 9NA. Crystal structure analysis of 9NA tailspike revealed a complete similar fold to P22 tailspike although they only share 36 % sequence identity. Moreover, 9NA tailspike possesses similar enzyme activity towards S. Typhimurium O antigen within conserved amino acids. These are responsible for a DNA ejection process from siphovirus 9NA triggered by lipopolysaccharide aggregates. 9NA expelled its DNA 30 times faster than podovirus P22 although the associated conformational change is controlled with a similar high activation barrier. The difference in DNA ejection velocity mirrors different tail morphologies and their efficiency to translate a carbohydrate recognition signal into action.
This thesis aims at a better mechanistic understanding of animal communities. Therefore, an allometry- and individual-based model has been developed which was used to simulate mammal and bird communities in heterogeneous landscapes, and to to better understand their response to landscape changes (habitat loss and fragmentation).
Structuring process models
(2012)
One can fairly adopt the ideas of Donald E. Knuth to conclude that process modeling is both a science and an art. Process modeling does have an aesthetic sense. Similar to composing an opera or writing a novel, process modeling is carried out by humans who undergo creative practices when engineering a process model. Therefore, the very same process can be modeled in a myriad number of ways. Once modeled, processes can be analyzed by employing scientific methods. Usually, process models are formalized as directed graphs, with nodes representing tasks and decisions, and directed arcs describing temporal constraints between the nodes. Common process definition languages, such as Business Process Model and Notation (BPMN) and Event-driven Process Chain (EPC) allow process analysts to define models with arbitrary complex topologies. The absence of structural constraints supports creativity and productivity, as there is no need to force ideas into a limited amount of available structural patterns. Nevertheless, it is often preferable that models follow certain structural rules. A well-known structural property of process models is (well-)structuredness. A process model is (well-)structured if and only if every node with multiple outgoing arcs (a split) has a corresponding node with multiple incoming arcs (a join), and vice versa, such that the set of nodes between the split and the join induces a single-entry-single-exit (SESE) region; otherwise the process model is unstructured. The motivations for well-structured process models are manifold: (i) Well-structured process models are easier to layout for visual representation as their formalizations are planar graphs. (ii) Well-structured process models are easier to comprehend by humans. (iii) Well-structured process models tend to have fewer errors than unstructured ones and it is less probable to introduce new errors when modifying a well-structured process model. (iv) Well-structured process models are better suited for analysis with many existing formal techniques applicable only for well-structured process models. (v) Well-structured process models are better suited for efficient execution and optimization, e.g., when discovering independent regions of a process model that can be executed concurrently. Consequently, there are process modeling languages that encourage well-structured modeling, e.g., Business Process Execution Language (BPEL) and ADEPT. However, the well-structured process modeling implies some limitations: (i) There exist processes that cannot be formalized as well-structured process models. (ii) There exist processes that when formalized as well-structured process models require a considerable duplication of modeling constructs. Rather than expecting well-structured modeling from start, we advocate for the absence of structural constraints when modeling. Afterwards, automated methods can suggest, upon request and whenever possible, alternative formalizations that are "better" structured, preferably well-structured. In this thesis, we study the problem of automatically transforming process models into equivalent well-structured models. The developed transformations are performed under a strong notion of behavioral equivalence which preserves concurrency. The findings are implemented in a tool, which is publicly available.
In this thesis, different aspects within the research field of protein spectro- and electro-chemistry on nanostructured materials are addressed. On the one hand, this work is related to the investigation of nanostructured transparent and conductive metal oxides as platform for the immobilization of electroactive enzymes. On the other hand the second part of this work is related to the immobilization of sulfite oxidase on gold nanoparticles modified electrode. Finally direct and mediated spectroelectrochemistry protein with high structure complexity such as the xanthine dehydrogenase from Rhodobacter capsulatus and its high homologues the mouse aldehyde oxidase homolog 1. Stable immobilization and reversible electrochemistry of cytochrome c in a transparent and conductive tin-doped and tin-rich indium oxide film with a well-defined mesoporosity is reported. The transparency and good conductivity, in combination with the large surface area of these materials, allow the incorporation of a high amount of electroactive biomolecules (between 250 and 2500 pmol cm-2) and their electrochemical and spectroscopic investigation. Both, the electrochemical behavior and the immobilization of proteins are influenced by the geometric parameters of the porous material, such as the structure and pore shape, the surface chemistry, as well as the protein size and charge. UV-Vis and resonance Raman spectroscopy, in combination with direct protein voltammetry, are employed for the characterization of cytochrome c immobilized in the mesoporous indium tin oxide and reveal no perturbation of the structural integrity of the redox protein. A long term protein immobilization is reached using these unmodified mesoporous indium oxide based materials, i.e. more than two weeks even at high ionic strength. The potential of this modified material as an amperometric biosensor for the detection of superoxide anions is demonstrated. A sensitivity of about 100 A M-1 m-2, in a linear measuring range of the superoxide concentration between 0.13 and 0.67 μM, is estimated. In addition an electrochemical switchable protein-based optical device is designed with the core part composed of cytochrome c immobilized on a mesoporous indium tin oxide film. A color developing redox sensitive dye is used as switchable component of the system. The cytochrome c-catalyzed oxidation of the dye by hydrogen peroxide is spectroscopically investigated. When the dye is co-immobilized with the protein, its redox state is easily controlled by application of an electrical potential at the supporting material. This enables to electrochemical reset the system to the initial state and repetitive signal generation. The case of negative charged proteins, which does not have a good interaction with the negative charged indium oxide based films, is also explored. The modification of an indium tin oxide film with a positive charged polymer and the employment of a antimony doped tin oxide film were investigated in this work in order to overcome the repulsion induced by similar charges of the protein and electrode. Human sulfite oxidase and its separated heme-containing domain are able to direct exchange electrons with the supporting material. A study of a new approach for sulfite biosensing, based on enhanced direct electron transfer of a human sulfite oxidase immobilized on a gold nanoparticles modified electrode is reported. The spherical gold nanoparticles were prepared via a novel method by reduction of HAuCl4 with branched poly(ethyleneimine) in an ionic liquid resulting in particles of about 10 nm in hydrodynamic diameter. These nanoparticles were covalently attached to a mercaptoundecanoic acid modified Au-electrode and act as platform where human sulfite oxidase is adsorbed. An enhanced interfacial electron transfer and electrocatalysis is therefore achieved. UV-Vis and resonance Raman spectroscopy, in combination with direct protein voltammetry, were employed for the characterization of the system and reveal no perturbation of the structural integrity of the redox protein. The proposed biosensor exhibited a quick steady-state current response, within 2 s and a linear detection range between 0.5 and 5.4 μM with high sensitivity (1.85 nA μM-1). The investigated system provides remarkable advantages, since it works at low applied potential and at very high ionic strength. Therefore these properties could make the proposed system useful in the development of bioelectronic devices and its application in real samples. Finally protein with high structure complexity such as the xanthine dehydrogenase from Rhodobacter capsulatus and the mouse aldehyde oxidase homolog 1 were spectroelectrochemically studied. It could be demonstrated that different cofactors present in the protein structure, like the FAD and the molybdenum cofactor, are able to directly exchange electrons with an electrode and are displayed as a single peak in a square wave voltammogram. Protein mutants bearing a serine substituted to the cysteines, bounding to the most exposed iron sulfur cluster additionally showed direct electron transfer which can be attributable to this cluster. On the other hand a mediated spectroelectrochemical titration of the protein bound FAD cofactor was performed in presence of transparent iron and cobalt complex mediators. The results showed the formation of the stable semiquinone and the fully reduced flavin. Two formal potentials for each single electron exchange step were then determined.
In the context of cosmological structure formation sheets, filaments and eventually halos form due to gravitational instabilities. It is noteworthy, that at all times, the majority of the baryons in the universe does not reside in the dense halos but in the filaments and the sheets of the intergalactic medium. While at higher redshifts of z > 2, these baryons can be detected via the absorption of light (originating from more distant sources) by neutral hydrogen at temperatures of T ~ 10^4 K (the Lyman-alpha forest), at lower redshifts only about 20 % can be found in this state. The remain (about 50 to 70 % of the total baryons mass) is unaccounted for by observational means. Numerical simulations predict that these missing baryons could reside in the filaments and sheets of the cosmic web at high temperatures of T = 10^4.5 - 10^7 K, but only at low to intermediate densities, and constitutes the warm-hot intergalactic medium (WHIM). The high temperatures of the WHIM are caused by the formation of shocks and the subsequent shock-heating of the gas. This results in a high degree of ionization and renders the reliable detection of the WHIM a challenging task. Recent high-resolution hydrodynamical simulations indicate that, at redshifts of z ~ 2, filaments are able to provide very massive galaxies with a significant amount of cool gas at temperatures of T ~ 10^4 K. This could have an important impact on the star-formation in those galaxies. It is therefore of principle importance to investigate the particular hydro- and thermodynamical conditions of these large filament structures. Density and temperature profiles, and velocity fields, are expected to leave their special imprint on spectroscopic observations. A potential multiphase structure may act as tracer in observational studies of the WHIM. In the context of cold streams, it is important to explore the processes, which regulate the amount of gas transported by the streams. This includes the time evolution of filaments, as well as possible quenching mechanisms. In this context, the halo mass range in which cold stream accretion occurs is of particular interest. In order to address these questions, we perform particular hydrodynamical simulations of very high resolution, and investigate the formation and evolution of prototype structures representing the typical filaments and sheets of the WHIM. We start with a comprehensive study of the one-dimensional collapse of a sinusoidal density perturbation (pancake formation) and examine the influence of radiative cooling, heating due to an UV background, thermal conduction, and the effect of small-scale perturbations given by the cosmological power spectrum. We use a set of simulations, parametrized by the wave length of the initial perturbation L. For L ~ 2 Mpc/h the collapse leads to shock-confined structures. As a result of radiative cooling and of heating due to an UV background, a relatively cold and dense core forms. With increasing L the core becomes denser and more concentrated. Thermal conduction enhances this trend and may lead to an evaporation of the core at very large L ~ 30 Mpc/h. When extending our simulations into three dimensions, instead of a pancake structure, we obtain a configuration consisting of well-defined sheets, filaments, and a gaseous halo. For L > 4 Mpc/h filaments form, which are fully confined by an accretion shock. As with the one-dimensional pancakes, they exhibit an isothermal core. Thus, our results confirm a multiphase structure, which may generate particular spectral tracers. We find that, after its formation, the core becomes shielded against further infall of gas onto the filament, and its mass content decreases with time. In the vicinity of the halo, the filament's core can be attributed to the cold streams found in other studies. We show, that the basic structure of these cold streams exists from the very beginning of the collapse process. Further on, the cross section of the streams is constricted by the outwards moving accretion shock of the halo. Thermal conduction leads to a complete evaporation of the cold stream for L > 6 Mpc/h. This corresponds to halos with a total mass higher than M_halo = 10^13 M_sun, and predicts that in more massive halos star-formation can not be sustained by cold streams. Far away from the gaseous halo, the temperature gradients in the filament are not sufficiently strong for thermal conduction to be effective.