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Many perceptual and cognitive tasks permit or require the integrated cooperation of specialized sensory channels, detectors, or other functionally separate units. In compound detection or discrimination tasks, 1 prominent general mechanism to model the combination of the output of different processing channels is probability summation. The classical example is the binocular summation model of Pirenne (1943), according to which a weak visual stimulus is detected if at least 1 of the 2 eyes detects this stimulus; as we review briefly, exactly the same reasoning is applied in numerous other fields. It is generally accepted that this mechanism necessarily predicts performance based on 2 (or more) channels to be superior to single channel performance, because 2 separate channels provide "2 chances" to succeed with the task. We argue that this reasoning is misleading because it neglects the increased opportunity with 2 channels not just for hits but also for false alarms and that there may well be no redundancy gain at all when performance is measured in terms of receiver operating characteristic curves. We illustrate and support these arguments with a visual detection experiment involving different spatial uncertainty conditions. Our arguments and findings have important implications for all models that, in one way or another, rest on, or incorporate, the notion of probability summation for the analysis of detection tasks, 2-alternative forced-choice tasks, and psychometric functions.
Preclinical work indicates that calcitriol restores vascular function by normalizing the endothelial expression of cyclooxygenase-2 and thromboxane-prostanoid receptors in conditions of estrogen deficiency and thus prevents the thromboxane-prostanoid receptor activation-induced inhibition of nitric oxide synthase. Since endothelial dysfunction is a key factor in the pathogenesis of cardiovascular diseases, this finding may have an important translational impact. It provides a clear rationale to use endothelial function in clinical trials aiming to find the optimal dose of vitamin D for the prevention of cardiovascular events in postmenopausal women.
Untitled
(2011)
The queerness of things not queer - entgrenzungen - Affekte und Materialitäten - Interventionen
(2012)
The role of knowledge in the policy process remains a central theoretical puzzle in policy analysis and political science. This article argues that an important yet missing piece of this puzzle is the systematic exploration of the political use of policy knowledge. While much of the recent debate has focused on the question of how the substantive use of knowledge can improve the quality of policy choices, our understanding of the political use of knowledge and its effects in the policy process has remained deficient in key respects. A revised conceptualization of the political use of knowledge is introduced that emphasizes how conflicting knowledge can be used to contest given structures of policy authority. This allows the analysis to differentiate between knowledge creep and knowledge shifts as two distinct types of knowledge effects in the policy process. While knowledge creep is associated with incremental policy change within existing policy structures, knowledge shifts are linked to more fundamental policy change in situations when the structures of policy authority undergo some level of transformation. The article concludes by identifying characteristics of the administrative structure of policy systems or sectors that make knowledge shifts more or less likely.
Language processing changes with the knowledge and use of two languages. The advantage of being bilingual comes at the expense of increased processing demands and processing costs. I suggest considering bilingual complexity including these demands and costs. The proposed model claims effortless monolingual processing. By integrating individual and situational variability, the model would lose its idealistic touch, even for monolinguals.