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We investigate the usefulness of complex flood damage models for predicting relative damage to residential buildings in a spatial and temporal transfer context. We apply eight different flood damage models to predict relative building damage for five historic flood events in two different regions of Germany. Model complexity is measured in terms of the number of explanatory variables which varies from 1 variable up to 10 variables which are singled out from 28 candidate variables. Model validation is based on empirical damage data, whereas observation uncertainty is taken into consideration. The comparison of model predictive performance shows that additional explanatory variables besides the water depth improve the predictive capability in a spatial and temporal transfer context, i.e., when the models are transferred to different regions and different flood events. Concerning the trade-off between predictive capability and reliability the model structure seem more important than the number of explanatory variables. Among the models considered, the reliability of Bayesian network-based predictions in space-time transfer is larger than for the remaining models, and the uncertainties associated with damage predictions are reflected more completely.
On the role of fluoro-substituted nucleosides in DNA radiosensitization for tumor radiation therapy
(2014)
Gemcitabine (2′,2′-difluorocytidine) is a well-known radiosensitizer routinely applied in concomitant chemoradiotherapy. During irradiation of biological media with high-energy radiation secondary low-energy (<10 eV) electrons are produced that can directly induce chemical bond breakage in DNA by dissociative electron attachment (DEA). Here, we investigate and compare DEA to the three molecules 2′-deoxycytidine, 2′-deoxy-5-fluorocytidine, and gemcitabine. Fluorination at specific molecular sites, i.e., nucleobase or sugar moiety, is found to control electron attachment and subsequent dissociation pathways. The presence of two fluorine atoms at the sugar ring results in more efficient electron attachment to the sugar moiety and subsequent bond cleavage. For the formation of the dehydrogenated nucleobase anion, we obtain an enhancement factor of 2.8 upon fluorination of the sugar, whereas the enhancement factor is 5.5 when the nucleobase is fluorinated. The observed fragmentation reactions suggest enhanced DNA strand breakage induced by secondary electrons when gemcitabine is incorporated into DNA.