Refine
Has Fulltext
- no (1281) (remove)
Year of publication
- 2021 (1281) (remove)
Document Type
- Article (1101)
- Doctoral Thesis (56)
- Conference Proceeding (32)
- Part of a Book (31)
- Review (19)
- Monograph/Edited Volume (13)
- Part of Periodical (10)
- Other (9)
- Habilitation Thesis (6)
- Contribution to a Periodical (2)
Language
- English (1281) (remove)
Keywords
- COVID-19 (18)
- Germany (9)
- climate change (9)
- machine learning (9)
- diffusion (8)
- Migration (7)
- analysis (7)
- embodied cognition (7)
- exercise (6)
- gender (6)
Institute
- Institut für Biochemie und Biologie (154)
- Institut für Physik und Astronomie (135)
- Institut für Chemie (126)
- Institut für Geowissenschaften (104)
- Department Psychologie (71)
- Fachgruppe Betriebswirtschaftslehre (69)
- Institut für Umweltwissenschaften und Geographie (67)
- Fachgruppe Politik- & Verwaltungswissenschaft (64)
- Institut für Ernährungswissenschaft (54)
- Department Sport- und Gesundheitswissenschaften (50)
Dysfunctional islets of Langerhans are a hallmark of type 2 diabetes (T2D). We hypothesize that differences in islet gene expression alternative splicing which can contribute to altered protein function also participate in islet dysfunction. RNA sequencing (RNAseq) data from islets of obese diabetes-resistant and diabetes-susceptible mice were analyzed for alternative splicing and its putative genetic and epigenetic modulators. We focused on the expression levels of chromatin modifiers and SNPs in regulatory sequences. We identified alternative splicing events in islets of diabetes-susceptible mice amongst others in genes linked to insulin secretion, endocytosis or ubiquitin-mediated proteolysis pathways. The expression pattern of 54 histones and chromatin modifiers, which may modulate splicing, were markedly downregulated in islets of diabetic animals. Furthermore, diabetes-susceptible mice carry SNPs in RNA-binding protein motifs and in splice sites potentially responsible for alternative splicing events. They also exhibit a larger exon skipping rate, e.g., in the diabetes gene Abcc8, which might affect protein function. Expression of the neuronal splicing factor Srrm4 which mediates inclusion of microexons in mRNA transcripts was markedly lower in islets of diabetes-prone compared to diabetes-resistant mice, correlating with a preferential skipping of SRRM4 target exons. The repression of Srrm4 expression is presumably mediated via a higher expression of miR-326-3p and miR-3547-3p in islets of diabetic mice. Thus, our study suggests that an altered splicing pattern in islets of diabetes-susceptible mice may contribute to an elevated T2D risk.
In this study, we investigate numerically the hydro-mechanical behavior of fractured crystalline rock due to one of the five hydraulic stimulations at the Pohang Enhanced Geothermal site in South Korea. We use the commercial code FracMan (Golder Associates) that enables studying hydro-mechanical coupled processes in fractured media in three dimensions combining the finite element method with a discrete fracture network. The software is used to simulate fluid pressure perturbation at fractures during hydraulic stimulation. Our numerical simulation shows that pressure history matching can be obtained by partitioning the treatment into separate phases. This results in adjusted stress-aperture relationships. The evolution of aperture adjustment implies that the stimulation mechanism could be a combination of hydraulic fracturing and shearing. The simulated extent of the 0.01 MPa overpressure contour at the end of the treatment equals to similar to 180 m around the injection point.
Moderate and temporary heat stresses prime plants to tolerate, and survive, a subsequent severe heat stress. Such acquired thermotolerance can be maintained for several days under normal growth conditions, and can create a heat stress memory. We recently demonstrated that plastid-localized small heat shock protein 21 ( HSP21) is a key component of heat stress memory in Arabidopsis thaliana. A sustained high abundance of HSP21 during the heat stress recovery phase extends heat stress memory. The level of HSP21 is negatively controlled by plastid-localized metalloprotease FtsH6 during heat stress recovery. Here, we demonstrate that autophagy, a cellular recycling mechanism, exerts additional control over HSP21 degradation. Genetic and chemical disruption of both metalloprotease activity and autophagy trigger superior HSP21 accumulation, thereby improving memory. Furthermore, we provide evidence that autophagy cargo receptor ATG8-INTERACTING PROTEIN1 (ATI1) is associated with heat stress memory. ATI1 bodies co-localize with both autophagosomes and HSP21, and their abundance and transport to the vacuole increase during heat stress recovery. Together, our results provide new insights into the module for control of the regulation of heat stress memory, in which two distinct protein degradation pathways act in concert to degrade HSP21, thereby enabling cells to recover from the heat stress effect at the cost of reducing the heat stress memory.
Protecting the vulnerable
(2021)
Contemporary pressures of climate change and migration are abetting the spread of (re)emerging infectious diseases (EIDs), including HIV, Ebola and tuberculosis (TB). While the fact remains that any person can become infected, those most affected are vulnerable populations. In Eastern and Southern Africa (ESA) these include marginalized groups such as people who sell sex, LGBTI and MSM, but more widely also adolescents. Adolescents and young adults represent a particularly vulnerable group, caught as they are on the cusp between child protections and adult citizenship claims, including to health and educational provisions and protections. Without, or with incomplete claims, members of marginalized and vulnerable communities are excluded from access to provisions and protections of health as part of human security, whether out of apathy, fear or jurisdiction or through (deliberate) neglect.
The chapter proceeds through the framework of human security, which puts the security of individuals at the centre of its analysis. This stands in contrast to the 1990s securitization argument which framed HIV as a threat to state security. This chapter analyzes unique challenges of vulnerable adolescent populations as these relate to HIV prevention and treatment access. In doing so, it pays special heed to the “double vulnerability” of non-citizenship and compromised citizenship among this cohort. By invoking the human security paradigm, this chapter explores HIV interventions as they pertain to and aim to protect vulnerable populations beyond borders.
Stochastic resetting, a diffusive process whose amplitude is reset to the origin at random times, is a vividly studied strategy to optimize encounter dynamics, e.g., in chemical reactions. Here we generalize the resetting step by introducing a random resetting amplitude such that the diffusing particle may be only partially reset towards the trajectory origin or even overshoot the origin in a resetting step. We introduce different scenarios for the random-amplitude stochastic resetting process and discuss the resulting dynamics. Direct applications are geophysical layering (stratigraphy) and population dynamics or financial markets, as well as generic search processes.
The genus Microhyla Tschudi, 1838 includes 52 species and is one of the most diverse genera of the family Microhylidae, being the most species-rich taxon of the Asian subfamily Microhylinae. The recent, rapid description of numerous new species of Microhyla with complex phylogenetic relationships has made the taxonomy of the group especially challenging. Several recent phylogenetic studies suggested paraphyly of Microhyla with respect to Glyphoglossus Gunther, 1869, and revealed three major phylogenetic lineages of mid-Eocene origin within this assemblage. However, comprehensive works assessing morphological variation among and within these lineages are absent. In the present study we investigate the generic taxonomy of Microhyla-Glyphoglossus assemblage based on a new phylogeny including 57 species, comparative morphological analysis of skeletons from cleared-and-stained specimens for 23 species, and detailed descriptions of generalized osteology based on volume-rendered micro-CT scans for five speciesal-together representing all major lineages within the group. The results confirm three highly divergent and well-supported clades that correspond with external and osteological morphological characteristics, as well as respective geographic distribution. Accordingly, acknowledging ancient divergence between these lineages and their significant morphological differentiation, we propose to consider these three lineages as distinct genera: Microhyla sensu stricto, Glyphoglossus, and a newly described genus, Nanohyla gen. nov.
Large earthquakes are usually modeled with simple planar fault surfaces or a combination of several planar fault segments. However, in general, earthquakes occur on faults that are non-planar and exhibit significant geometrical variations in both the along-strike and down-dip directions at all spatial scales. Mapping of surface fault ruptures and high-resolution geodetic observations are increasingly revealing complex fault geometries near the surface and accurate locations of aftershocks often indicate geometrical complexities at depth. With better geodetic data and observations of fault ruptures, more details of complex fault geometries can be estimated resulting in more realistic fault models of large earthquakes. To address this topic, we here parametrize non-planar fault geometries with a set of polynomial parameters that allow for both along-strike and down-dip variations in the fault geometry. Our methodology uses Bayesian inference to estimate the non-planar fault parameters from geodetic data, yielding an ensemble of plausible models that characterize the uncertainties of the non-planar fault geometry and the fault slip. The method is demonstrated using synthetic tests considering slip spatially distributed on a single continuous finite non-planar fault surface with varying dip and strike angles both in the down-dip and along-strike directions. The results show that fault-slip estimations can be biased when a simple planar fault geometry is assumed in presence of significant non-planar geometrical variations. Our method can help to model earthquake fault sources in a more realistic way and may be extended to include multiple non-planar fault segments or other geometrical fault complexities.
Tula orthohantavirus (TULV) is a rodent-borne hantavirus with broad geographical distribution in Europe. Its major reservoir is the common vole (Microtus arvalis), but TULV has also been detected in closely related vole species. Given the large distributional range and high amplitude population dynamics of common voles, this host-pathogen complex presents an ideal system to study the complex mechanisms of pathogen transmission in a wild rodent reservoir. We investigated the dynamics of TULV prevalence and the subsequent potential effects on the molecular evolution of TULV in common voles of the Central evolutionary lineage. Rodents were trapped for three years in four regions of Germany and samples were analyzed for the presence of TULV-reactive antibodies and TULV RNA with subsequent sequence determination. The results show that individual (sex) and population-level factors (abundance) of hosts were significant predictors of local TULV dynamics. At the large geographic scale, different phylogenetic TULV clades and an overall isolation-by-distance pattern in virus sequences were detected, while at the small scale (<4 km) this depended on the study area. In combination with an overall delayed density dependence, our results highlight that frequent, localized bottleneck events for the common vole and TULV do occur and can be offset by local recolonization dynamics.
Comb-like geometric constraints leading to emergence of the time-fractional Schrödinger equation
(2021)
This paper presents an overview over several examples, where the comb-like geometric constraints lead to emergence of the time-fractional Schrodinger equation. Motion of a quantum object on a comb structure is modeled by a suitable modification of the kinetic energy operator, obtained by insertion of the Dirac delta function in the Laplacian. First, we consider motion of a free particle on two- and three-dimensional comb structures, and then we extend the study to the interacting cases. A general form of a nonlocal term, which describes the interactions of the particle with the medium, is included in the Hamiltonian, and later on, the cases of constant and Dirac delta potentials are analyzed. At the end, we discuss the case of non-integer dimensions, considering separately the case of fractal dimension between one and two, and the case of fractal dimension between two and three. All these examples show that even though we are starting with the standard time-dependent Schrodinger equation on a comb, the time-fractional equation for the Green's functions appears, due to these specific geometric constraints.