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This study deals with the East Beni Suef Basin (Eastern Desert, Egypt) and aims to evaluate the source-generative potential, reconstruct the burial and thermal history, examine the most influential parameters on thermal maturity modeling, and improve on the models already published for the West Beni Suef to ultimately formulate a complete picture of the whole basin evolution.
Source rock evaluation was carried out based on TOC, Rock-Eval pyrolysis, and visual kerogen petrography analyses. Three kerogen types (II, II/III, and III) are distinguished in the East Beni Suef Basin, where the Abu Roash "F" Member acts as the main source rock with good to excellent source potential, oil-prone mainly type II kerogen, and immature to marginal maturity levels.
The burial history shows four depositional and erosional phases linked with the tectonic evolution of the basin. A hiatus (due to erosion or non-deposition) has occurred during the Late Eocene-Oligocene in the East Beni Suef Basin, while the West Beni Suef Basin has continued subsiding.
Sedimentation began later (Middle to Late Albian) with lower rates in the East Beni Suef Basin compared with the West Beni Suef Basin (Early Albian). The Abu Roash "F" source rock exists in the early oil window with a present-day transformation ratio of about 19% and 21% in the East and West Beni Suef Basin, respectively, while the Lower Kharita source rock, which is only recorded in the West Beni Suef Basin, has reached the late oil window with a present-day transformation ratio of about 70%.
The magnitude of erosion and heat flow have proportional and mutual effects on thermal maturity.
We present three possible scenarios of basin modeling in the East Beni Suef Basin concerning the erosion from the Apollonia and Dabaa formations.
Results of this work can serve as a basis for subsequent 2D and/or 3D basin modeling, which are highly recommended to further investigate the petroleum system evolution of the Beni Suef Basin.
This study examines the discourse basis for referent accessibility and its relation to the choice of referring expressions by children with Autism Spectrum Disorder (ASD) and typically developing children. The aim is to delineate how the linguistic and extra-linguistic context affects referent accessibility to the speaker. The study also examines the degree to which accessibility effects are modulated by cognitive factors such as working memory capacity. In the study, the contrast levels between the referent and a competitor (one contrast/two contrasts) and the syntactic prominence of the referent (subject/object position in the preceding question) were manipulated in an elicited production task. The results provide evidence that the referring expressions of children with ASD correlate with the discourse status of referents to a similar extent as in typically developing controls. All children were more likely to refer with lexical NPs to referents that contrasted on two levels with a highly prominent competitor, compared to referents that contrasted on one level. They were also more likely to produce pronouns for referents previously mentioned in the subject than the object position. The effect of both discourse factors was modulated by the age and working memory capacity of the children with and without ASD. Accordingly, the study suggests that children with ASD do not generally differ from children with typical development in their referential choices when the discourse status of a referent allows them to model the referent's accessibility from their own discourse perspective in a way that is modulated by working memory capacity.
The folding of single-stranded telomeric DNA into guanine (G) quadruplexes is a conformational change that plays a major role in sensing and drug targeting. The telomeric DNA can be placed on DNA origami nanostructures to make the folding process extremely selective for K+ ions even in the presence of high Na+ concentrations. Here, we demonstrate that the K+-selective G-quadruplex formation is reversible when using a cryptand to remove K+ from the G-quadruplex. We present a full characterization of the reversible switching between single-stranded telomeric DNA and G-quadruplex structures using Förster resonance energy transfer (FRET) between the dyes fluorescein (FAM) and cyanine3 (Cy3). When attached to the DNA origami platform, the G-quadruplex switch can be incorporated into more complex photonic networks, which is demonstrated for a three-color and a four-color FRET cascade from FAM over Cy3 and Cy5 to IRDye700 with G-quadruplex-Cy3 acting as a switchable transmitter.
The folding of single-stranded telomeric DNA into guanine (G) quadruplexes is a conformational change that plays a major role in sensing and drug targeting. The telomeric DNA can be placed on DNA origami nanostructures to make the folding process extremely selective for K+ ions even in the presence of high Na+ concentrations. Here, we demonstrate that the K+-selective G-quadruplex formation is reversible when using a cryptand to remove K+ from the G-quadruplex. We present a full characterization of the reversible switching between single-stranded telomeric DNA and G-quadruplex structures using Förster resonance energy transfer (FRET) between the dyes fluorescein (FAM) and cyanine3 (Cy3). When attached to the DNA origami platform, the G-quadruplex switch can be incorporated into more complex photonic networks, which is demonstrated for a three-color and a four-color FRET cascade from FAM over Cy3 and Cy5 to IRDye700 with G-quadruplex-Cy3 acting as a switchable transmitter.
Climate change is expected to exacerbate the current threats to freshwater ecosystems, yet multifaceted studies on the potential impacts of climate change on freshwater biodiversity at scales that inform management planning are lacking. The aim of this study was to fill this void through the development of a novel framework for assessing climate change vulnerability tailored to freshwater ecosystems. The three dimensions of climate change vulnerability are as follows: (i) exposure to climate change, (ii) sensitivity to altered environmental conditions and (iii) resilience potential. Our vulnerability framework includes 1685 freshwater species of plants, fishes, molluscs, odonates, amphibians, crayfish and turtles alongside key features within and between catchments, such as topography and connectivity. Several methodologies were used to combine these dimensions across a variety of future climate change models and scenarios. The resulting indices were overlaid to assess the vulnerability of European freshwater ecosystems at the catchment scale (18 783 catchments). The Balkan Lakes Ohrid and Prespa and Mediterranean islands emerge as most vulnerable to climate change. For the 2030s, we showed a consensus among the applied methods whereby up to 573 lake and river catchments are highly vulnerable to climate change. The anthropogenic disruption of hydrological habitat connectivity by dams is the major factor reducing climate change resilience. A gap analysis demonstrated that the current European protected area network covers <25% of the most vulnerable catchments. Practical steps need to be taken to ensure the persistence of freshwater biodiversity under climate change. Priority should be placed on enhancing stakeholder cooperation at the major basin scale towards preventing further degradation of freshwater ecosystems and maintaining connectivity among catchments. The catchments identified as most vulnerable to climate change provide preliminary targets for development of climate change conservation management and mitigation strategies.
Although morphosyntax has been identified as a major source of difficulty for adult (nonnative) language learners, most previous studies have examined a limited set of largely affix-based phenomena. Little is known about word-based morphosyntax in late bilinguals and of how morphosyntax is represented and processed in a nonnative speaker's lexicon. To address these questions, we report results from two behavioral experiments investigating stem variants of strong verbs in German (which encode features such as tense, person, and number) in groups of advanced adult learners as well as native speakers of German. Although the late bilinguals were highly proficient in German, the results of a lexical priming experiment revealed clear native-nonnative differences. We argue that lexical representation and processing relies less on morphosyntactic information in a nonnative than in a native language.
Although morphosyntax has been identified as a major source of difficulty for adult (nonnative) language learners, most previous studies have examined a limited set of largely affix-based phenomena. Little is known about word-based morphosyntax in late bilinguals and of how morphosyntax is represented and processed in a nonnative speaker's lexicon. To address these questions, we report results from two behavioral experiments investigating stem variants of strong verbs in German (which encode features such as tense, person, and number) in groups of advanced adult learners as well as native speakers of German. Although the late bilinguals were highly proficient in German, the results of a lexical priming experiment revealed clear native-nonnative differences. We argue that lexical representation and processing relies less on morphosyntactic information in a nonnative than in a native language.
A water soluble fluorescent polymer as a dual colour sensor for temperature and a specific protein
(2013)
We present two thermoresponsive water soluble copolymers prepared via free radical statistical copolymerization of N-isopropylacrylamide (NIPAm) and of oligo(ethylene glycol) methacrylates (OEGMAs), respectively, with a solvatochromic 7-(diethylamino)-3-carboxy-coumarin (DEAC)- functionalized monomer. In aqueous solutions, the NIPAm-based copolymer exhibits characteristic changes in its fluorescence profile in response to a change in solution temperature as well as to the presence of a specific protein, namely an anti-DEAC antibody. This polymer emits only weakly at low temperatures, but exhibits a marked fluorescence enhancement accompanied by a change in its emission colour when heated above its cloud point. Such drastic changes in the fluorescence and absorbance spectra are observed also upon injection of the anti-DEAC antibody, attributed to the specific binding of the antibody to DEAC moieties. Importantly, protein binding occurs exclusively when the polymer is in the well hydrated state below the cloud point, enabling a temperature control on the molecular recognition event. On the other hand, heating of the polymer–antibody complexes releases a fraction of the bound antibody. In the presence of the DEAC-functionalized monomer in this mixture, the released antibody competitively binds to the monomer and the antibody-free chains of the polymer undergo a more effective collapse and inter-aggregation. In contrast, the emission properties of the OEGMA-based analogous copolymer are rather insensitive to the thermally induced phase transition or to antibody binding. These opposite behaviours underline the need for a carefully tailored molecular design of responsive polymers aimed at specific applications, such as biosensing.
Meaning and alternatives
(2022)
Alternatives and competition in language are pervasive at all levels of linguistic analysis. More specifically, alternatives have been argued to play a prominent role in an ever-growing class of phenomena in the investigation of natural language meaning. In this article, we focus on scalar implicatures, as they are arguably the most paradigmatic case of an alternative-based phenomenon. We first review the main challenge for theories of alternatives, the so-called symmetry problem, and we briefly discuss how it has shaped the different approaches to alternatives. We then turn to two more recent challenges concerning scalar diversity and the inferences of sentences with multiple scalars. Finally, we describe several related alternative-based phenomena and recent conceptual approaches to alternatives. As we discuss, while important progress has been made, much more work is needed both on the theoretical side and on understanding the empirical landscape better.
The concept of similitude is commonly employed in the fields of fluid dynamics and engineering but rarely used in cryospheric research. Here we apply this method to the problem of ice flow to examine the dynamic similitude of isothermal ice sheets in shallow-shelf approximation against the scaling of their geometry and physical parameters. Carrying out a dimensional analysis of the stress balance we obtain dimensionless numbers that characterize the flow. Requiring that these numbers remain the same under scaling we obtain conditions that relate the geometric scaling factors, the parameters for the ice softness, surface mass balance and basal friction as well as the ice-sheet intrinsic response time to each other. We demonstrate that these scaling laws are the same for both the (two-dimensional) flow-line case and the three-dimensional case. The theoretically predicted ice-sheet scaling behavior agrees with results from numerical simulations that we conduct in flow-line and three-dimensional conceptual setups. We further investigate analytically the implications of geometric scaling of ice sheets for their response time. With this study we provide a framework which, under several assumptions, allows for a fundamental comparison of the ice-dynamic behavior across different scales. It proves to be useful in the design of conceptual numerical model setups and could also be helpful for designing laboratory glacier experiments. The concept might also be applied to real-world systems, e.g., to examine the response times of glaciers, ice streams or ice sheets to climatic perturbations.