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Our understanding of the impact of climate-driven environmental change on prehistoric human populations is hampered by the scarcity of continuous paleoenvironmental records in the vicinity of archaeological sites. Here we compare a continuous paleoclimatic record of the last 20 ka before present from the Chew Bahir basin, southwest Ethiopia, with the available archaeological record of human presence in the region. The correlation of this record with orbitally-driven insolation variations suggests a complex nonlinear response of the environment to climate forcing, reflected in several long-term and short-term transitions between wet and dry conditions, resulting in abrupt changes between favorable and unfavorable living conditions for humans. Correlating the archaeological record in the surrounding region of the Chew Bahir basin, presumably including montane and lake-marginal refugia for human populations, with our climate record suggests a complex interplay between humans and their environment during the last 20 ka. The result may contribute to our understanding of how a dynamic environment may have impacted the adaptation and dispersal of early humans in eastern Africa. (C) 2015 Elsevier Ltd. All rights reserved.
The interaction between endothelial cells and pericytes is crucial for the stabilization of newly formed vessels in angiogenesis. The comprehension of the mechanisms regulating peiicyte recruitment might open therapeutical perspectives on vascular-related pathologies. Sphingosine 1phosphate (SIP) is a bioactive sphingolipid that derives from sphingomyelin catabolism and regulates biological functions in cell survival, proliferation, and differentiation. In this study, we aimed to identify the role of SIP axis in the intercellular communication between human mesenchymal progenitor mesoangioblasts (MAB) and endothelial cells (human microvascular endothelial cells (HMVEC)) in the formation of capillary-like structures. We demonstrated that the SIP biosynthetic pathway brought about by sphingosine kinases (SK) SKI and SK2 as well as spinster homolog 2 (SPNS2) transporter in H-MVEC is crucial for MAB migration measured by Boyden chambers and for the formation and stabilization of capillary-like structures in a 3D Matrigel culture. Moreover, the conditioned medium (CM) harvested from HMVEC, where SKI, 5K2, and SPNS2 were down-regulated, exerted a significantly diminished effect on MAB capillary morphogenesis and migration. Notably, we demonstrated that S I Pi and Si p3 receptors were positively involved in CM-induced capillary-like formation and migration, while S I P2 exerted a negative role on CM-induced migratory action of MAB. Finally, SK inhibition as well as MAB SlPi and S1P3 down-regulation impaired HMVEC-MAB cross-talk significantly reducing in vivo angiogenesis evaluated by Matrigel plug assay. These findings individuate novel targets for the employment of MAB in vascular-related pathologic conditions.