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Year of publication
- 2010 (817) (remove)
Document Type
- Article (817) (remove)
Keywords
- Consolidation (14)
- Deutschland (14)
- European Union (14)
- Europäische Union (14)
- Germany (14)
- Integration (14)
- Poland (14)
- Polen (14)
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Institute
- Institut für Biochemie und Biologie (111)
- Institut für Romanistik (83)
- Institut für Chemie (71)
- Institut für Physik und Astronomie (69)
- Institut für Geowissenschaften (66)
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- Department Erziehungswissenschaft (24)
Riaño-Pachón, Diego Mauricio ; Kleessen, Sabrina ; Neigenfind, Jost ; Durek, Pawel ; Weber, Elke ; Engelsberger, Wolfgang R. ; Walther, Dirk ; Selbig, Joachim ; Schulze, Waltraud X. ; Kersten, Birgit
Background: Protein phosphorylation is an important post-translational modification influencing many aspects of dynamic cellular behavior. Site-specific phosphorylation of amino acid residues serine, threonine, and tyrosine can have profound effects on protein structure, activity, stability, and interaction with other biomolecules. Phosphorylation sites can be affected in diverse ways in members of any species, one such way is through single nucleotide polymorphisms (SNPs). The availability of large numbers of experimentally identified phosphorylation sites, and of natural variation datasets in Arabidopsis thaliana prompted us to analyze the effect of non-synonymous SNPs (nsSNPs) onto phosphorylation sites.
Results: From the analyses of 7,178 experimentally identified phosphorylation sites we found that: (i) Proteins with multiple phosphorylation sites occur more often than expected by chance. (ii) Phosphorylation hotspots show a preference to be located outside conserved domains. (iii) nsSNPs affected experimental phosphorylation sites as much as the corresponding non-phosphorylated amino acid residues. (iv) Losses of experimental phosphorylation sites by nsSNPs were identified in 86 A. thaliana proteins, among them receptor proteins were overrepresented.
These results were confirmed by similar analyses of predicted phosphorylation sites in A. thaliana. In addition, predicted threonine phosphorylation sites showed a significant enrichment of nsSNPs towards asparagines and a significant depletion of the synonymous substitution. Proteins in which predicted phosphorylation sites were affected by nsSNPs (loss and gain), were determined to be mainly receptor proteins, stress response proteins and proteins involved in nucleotide and protein binding. Proteins involved in metabolism, catalytic activity and biosynthesis were less affected.
Conclusions: We analyzed more than 7,100 experimentally identified phosphorylation sites in almost 4,300 protein-coding loci in silico, thus constituting the largest phosphoproteomics dataset for A. thaliana available to date. Our findings suggest a relatively high variability in the presence or absence of phosphorylation sites between different natural accessions in receptor and other proteins involved in signal transduction. Elucidating the effect of phosphorylation sites affected by nsSNPs on adaptive responses represents an exciting research goal for the future.
Editorial
(2010)
In der Wissenschaft sollten Geburtstage oder Jubiläen bestenfalls Anlass, nicht aber der eigentliche Grund sein, sich in Form eines Schwerpunktheftes erneut mit dem Werk eines wichtigen Vertreters der Zunft zu befassen. Nur allzu leicht geraten Rückblicke zu einer bloßen Einordnung eines Werkes in den Kontext seiner Zeit und beschränken sich damit auf seine schlichte Historisierung. Das lange Schaffen Robert King Mertons ließe sich ohne Probleme als bedeutender Teil der Geschichte der Soziologie in der zweiten Hälfte des 20. Jahrhunderts beschreiben. Doch Merton selbst hat schon früh betont, dass in der Wissenschaft ein grundlegender Unterschied zwischen erzählter (Wissenschafts-)Geschichte und systematischer Analyse eines klassischen theoretischen Werkes besteht. In diesem Sinne geht es darum, jenem Diktum Alfred N. Whiteheads gerecht zu werden, das Merton selbst seinem Hauptwerk Social Theory and Social Structure vorangestellt hat: „A science that hesitates to forget its founders is lost.“ Damit sollte keineswegs die fortbestehende Bedeutung einer Auseinandersetzung mit den klassischen Texten der Soziologie in Zweifel gezogen werden, aber eben nicht in der Form immer wiederkehrender Exegese, die zum gebetsmühlenhaften Wiederholen bereits bekannten Wissens oder zu dessen Banalisierung führen muss. Vielmehr ging es Merton darum, dass der theoretische Wissensfundus sowie die forschungspraktischen und methodischen Erfahrungen und Kenntnisse der Soziologie im Zentrum der Beschäftigung mit den Klassikern und Gründervätern der Disziplin stehen sollten.
Mooij, Wolf M. ; Trolle, Dennis ; Jeppesen, Erik ; Arhonditsis, George B. ; Belolipetsky, Pavel V. ; Chitamwebwa, Deonatus B. R. ; Degermendzhy, Andrey G. ; DeAngelis, Donald L. ; Domis, Lisette Nicole de Senerpont ; Downing, Andrea S. ; Elliott, J. Alex ; Fragoso Jr, Carlos Ruberto ; Gaedke, Ursula ; Genova, Svetlana N. ; Gulati, Ramesh D. ; Håkanson, Lars ; Hamilton, David P. ; Hipsey, Matthew R. ; ‘t Hoen, Jochem ; Hülsmann, Stephan ; Los, F. Hans ; Makler-Pick, Vardit ; Petzoldt, Thomas ; Prokopkin, Igor G. ; Rinke, Karsten ; Schep, Sebastiaan A. ; Tominaga, Koji ; Van Dam, Anne A. ; Van Nes, Egbert H. ; Wells, Scott A. ; Janse, Jan H.
A large number and wide variety of lake ecosystem models have been developed and published during the past four decades. We identify two challenges for making further progress in this field. One such challenge is to avoid developing more models largely following the concept of others ('reinventing the wheel'). The other challenge is to avoid focusing on only one type of model, while ignoring new and diverse approaches that have become available ('having tunnel vision'). In this paper, we aim at improving the awareness of existing models and knowledge of concurrent approaches in lake ecosystem modelling, without covering all possible model tools and avenues. First, we present a broad variety of modelling approaches. To illustrate these approaches, we give brief descriptions of rather arbitrarily selected sets of specific models. We deal with static models (steady state and regression models), complex dynamic models (CAEDYM, CE-QUAL-W2, Delft 3D-ECO, LakeMab, LakeWeb, MyLake, PCLake, PROTECH, SALMO), structurally dynamic models and minimal dynamic models. We also discuss a group of approaches that could all be classified as individual based: super-individual models (Piscator, Charisma), physiologically structured models, stage-structured models and traitbased models. We briefly mention genetic algorithms, neural networks, Kalman filters and fuzzy logic. Thereafter, we zoom in, as an in-depth example, on the multi-decadal development and application of the lake ecosystem model PCLake and related models (PCLake Metamodel, Lake Shira Model, IPH-TRIM3D-PCLake). In the discussion, we argue that while the historical development of each approach and model is understandable given its 'leading principle', there are many opportunities for combining approaches. We take the point of view that a single 'right' approach does not exist and should not be strived for. Instead, multiple modelling approaches, applied concurrently to a given problem, can help develop an integrative view on the functioning of lake ecosystems. We end with a set of specific recommendations that may be of help in the further development of lake ecosystem models.
Der Beitrag diskutiert Genese, Bedeutungsgehalt und theoretischen Kontext des Merton’schen Konzepts der Opportunitätsstruktur und des von ihm bei Weber entliehenen Konzepts der Lebenschancen. Die These lautet, dass beide Konzepte konflikttheoretisch interpretiert werden müssen, damit sie ihr volles analytisches und erklärendes Potenzial zur Analyse zentraler sozialer Konflikte entfalten können. Es wird davon ausgegangen, dass beide Konzepte in ihrem Bedeutungsgehalt konvergieren, ein konflikttheoretisch inspiriertes Verständnis aber unterschiedliche theoretische Strategien erfordert. Während die Opportunitätsstrukturen jenseits des Merton’schen Verständnisses reinterpretiert werden müssen, um verstehen zu können, dass das Handeln sozialer Akteure die Optionen anderer beschränken kann, ist für die Lebenschancen ein Zurück zu Max Webers ursprünglicher Idee angezeigt, um der Bedeutung sozialer Schließung als sozialen Mechanismus einer Auseinandersetzung um knappe Güter nachgehen zu können
The Visigoths as the other
(2010)
An analysis of Roman -Visigothic relations in different terms than the usual presupposition of constant military and confessional/Christia n antagonism. Structuralist methodology demonstrates how Roman needs at precise historical moments determ in e how Visigoths were perceived and, therefore, portrayed in our source.
Athanarich, Alarich, Athaulf
(2010)
In den drei Generationen von Athanarich bis Athaulf unterlag die terwingische/westgotische Konzeption und Ausübung von Herrschaft einem tiefgreifenden Wandlungsprozeß. Athanarich, der letzte „Richter“ der Terwingen regierte in traditioneller Weise, innerhalb der (sakralen) Grenzen seiner Position und ohne seinen Machtanspruch durch römische Ämter oder Titel zu stärken. Alarich etablierte ein Heerkönigtum und trug durch die Erfolge, zu denen er seine Gruppe führte, wesentlich zur Ethnogenese der Westgoten bei. Athaulf, sein Schwiegersohn und Nachfolger, unternahm durch seine Heirat mit Galla Placidia, der Halbschwester des Kaisers Honorius einen neuartigen Versuch, die Westgoten ins weströmische Reich zu integrieren.
We show that the residue density of the logarithm of a generalized Laplacian on a closed manifold definesan invariant polynomial-valued differential form. We express it in terms of a finite sum of residues ofclassical pseudodifferential symbols. In the case of the square of a Dirac operator, these formulas providea pedestrian proof of the Atiyah–Singer formula for a pure Dirac operator in four dimensions and for atwisted Dirac operator on a flat space of any dimension. These correspond to special cases of a moregeneral formula by Scott and Zagier. In our approach, which is of perturbative nature, we use either aCampbell–Hausdorff formula derived by Okikiolu or a noncommutative Taylor-type formula.
Aktuelle Diskussionen im Kontext des nachhaltigen Konsums sind ohne den LOHAS (Lifestyle of Health and Sustainability) als neuartige Zielgruppe kaum noch denkbar. Auch wenn der LOHAS die zentralen Anforderungen an das Lebensstilkonzept erfüllt, so lassen sich die abgeleiteten Implikationen nur schwierig in ein operativ erfolgreiches Nachhaltigkeitsmarketing übertragen. Die Verortung des LOHAS innerhalb der Sinus-Milieus kann die Unschärfe dieses Ansatzes reduzieren und so zusätzlich Informationen für das Marketing bereitstellen.
Parafoveal load of word N+1 modulates preprocessing effectiveness of word N+2 in chinese reading
(2010)
'...just as it would have been in 1861' : stuttering colonial beginnings in ABC's outback house
(2010)
Investigating culture from a linguistic perspective : an exemplification with Hong Kong English
(2010)
Objective: We investigated in a high-risk sample the differential impact of biological and psychosocial risk factors on antisocial behaviour pathways. Method: One hundred and thirty-eight boys and 155 girls born at differing degrees of obstetric and psychosocial risk were examined from birth until adolescence. Childhood temperament was assessed by a highly-structured parent-interview and standardized behavioural observations, adolescent temperament was measured by self-report. Neurodevelopmental variables were assessed by age-specific developmental tests. Emotional and behaviour problems were measured at the ages of 8 and 15 by the Achenbach scales. Results: In both genders, psychosocial adversity and early self-control temperament were strongly associated with early-onset persistent (EOP) antisocial behaviour. Psychosocial adversity and more severe externalizing problems differentiated the EOP from childhood-limited (CL) pathway. In girls, adolescent-onset (AO) antisocial behaviour was strongly associated with novelty seeking at 15 years. Conclusion: Our findings emphasize the need for early support and intervention in psychosocially disadvantaged families.
Ambiente e aspetti meteorologici nei testi letterari degli autori italiani in Germania (1964 - 2004)
(2010)
Der Beitrag geht mit den Texten des Autors Bernd Wagner auf eine Reise, die sowohl unterschiedliche Raeume wie unterschiedliche Zeiten betrifft. Insbesondere die Zeitmauer von Berlin (Ost) nach Berlin (West), die in Wagners Leben einen tiefen Einschnitt hinterliess, zeigt die Dialektik von Diskontinuitaet und Kontinuitaet im Denken und Schreiben Bernd Wagners. Bereits fuer den DDR-Autor Wagner waren Zeitreisen als "Reisen im Kopf" (so auch der Titel seines letzten Bandes in der offiziellen DDR-Literatur) ein schier unerschoepfliches Thema unangepassten Erzaehlens. Es entstanden durch die Erzaehlung Freiraeume, die von der Phantasie erschlossen wurden und die sich ueber die Mauern und Grenzen des tatsaechlichen Lebens hinwegsetzten. Mit der "Wut im Koffer" zeigt der Reisende Wagner auch nach dem Mauerfall, dass sein Reisegepaeck immer griffbereit ist. Ob es ihn nach Chihuahua oder Bali verschlaegt - er bleibt neugierig den eigenen Wegen auf der Spur.