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Cell culture and western blotting studies revealed that aflatoxin B-1 (AFB(1)) inhibits the biosynthesis of two of the constituent polypeptides of signal recognition particle (SRP) (SRP54 and 72). SRP escorts polyribosomes carrying signal peptides from free form in the cytosol to the bound form on endoplasmic reticulum (ER) membrane during protein targeting. These effects of AFB(1) on SRP biosynthesis may inhibit the formation of functional SRP Our experiments have further shown that AFB(1) also inhibits the biosynthesis/translocation of a secretory protein, preprolactin, which fails to appear in the lumen of ER consequent to the treatment with this hepatocarcinogen. The results of the experiments presented in this article therefore enable us to infer for the first time that aflatoxin B-1 may inhibit the functioning of SRP as an escort and deplete the ER of polyribosomes for secretory protein synthesis. As these secretory proteins are important components of the plasma membrane, gap junctions and intercellular matrix, their absence from these locations could disturb cell to cell communication leading to tumorigenesis.
The four dominant theories of reasoning from conditionals are translated into formal models: The theory of mental models (Johnson-Laird, P. N., & Byrne, R. M. J. (2002). Conditionals: a theory of meaning, pragmatics, and inference. Psychological Review, 109, 646-678), the suppositional theory (Evans, J. S. B. T., & Over, D. E. (2004). If. Oxford: Oxford University Press), a dual-process variant of the model theory (Verschueren, N., Schaeken, W., & d'Ydewalle, G. (2005). A dual-process specification of causal conditional reasoning. Thinking & Reasoning, 11, 278-293), and the probabilistic theory (Oaksford, M., Chater, N., & Larkin, J. (2000). Probabilities and polarity biases in conditional inference. Journal of Experimental Psychology: Learning, Memory, and Cognition, 26, 883-899). The first three theories are formalized as multinomial models. The models are applied to the frequencies of patterns of acceptance or rejection across the four basic inferences modus ponens, acceptance of the consequent, denial of the antecedent, and modus tollens. Model fits are assessed for two large data sets, one representing reasoning with abstract, basic conditionals, the other reflecting reasoning with pseudo-realistic causal and non-causal conditionals. The best account of the data was provided by a modified version of the mental-model theory, augmented by directionality, and by the dual-process model.
The consumption of arabinoxylan, a soluble fibre fraction, has been shown to improve glycemic control in type 2 diabetic subjects. Soluble dietary fibre may modulate gastrointestinal or adipose tissue hormones regulating food intake. The present study investigated the effects of arabinoxylan consumption on serum glucose, insulin, lipids, leptin, adiponectin and resistin in subjects with impaired glucose tolerance. In a randomized, single-blind, controlled, crossover intervention trial, 11 adults consumed white bread rolls as either placebo or supplemented with 15g arabinoxylan for 6 weeks with a 6-week washout period. Fasting serum glucose, insulin, triglycerides, unesterified fatty acids, apolipoprotein A1 and B, adiponectin, resistin and leptin were assessed before and after intervention. Fasting serum glucose, serum triglycerides and apolipoprotein A-1 were significantly lower during arabinoxylan consumption compared to placebo (p = 0.029, p = 0.047; p = 0.029, respectively). No effects of arabinoxylan were observed for insulin, adiponectin, leptin and resistin as well as for apolipoprotein B, and unesterified fatty acids. In conclusion, the consumption of AX in subjects with impaired glucose tolerance improved fasting serum glucose, and triglycerides. However, this beneficial effect was not accompanied by changes in fasting adipokine concentrations.
In his short paper of 1886, the neogrammarian linguist Delbruck sketches his views on normal language processing and their relevance for the interpretation of some of the symptoms of progressive anomic aphasia. In particular, he discusses proper name impairments, verb and abstract noun superiority and the predominance of semantically related errors. Furthermore, he suggests that part of speech, morphology and word order may be preserved in this condition. This historical document has been lost in oblivion but the original ideas and their relevance for contemporary discussions merit a revival.
Question: Is there a relationship between size and death in the Iona-lived, deep-rooted tree, Acacia erioloba, in a semi-arid savanna? What is the size-class distribution of A. erioloba mortality? Does the mortality distribution differ from total tree size distribution? Does A. erioloba mortality distribution match the mortality distributions recorded thus far in other environments? Location: Dronfield Ranch, near Kimberley, Kalahari, South Africa. Methods: A combination of aerial photographs and a satellite image covering 61 year was used to provide long-term spatial data on mortality. We used aerial photographs of the study area from 1940, 1964, 1984, 1993 and a satellite image from 2001 to follow three plots covering 510 ha. We were able to identify and individually follow ca. 3000 individual trees from 1940 till 2001. Results: The total number of trees increased over time. No relationship between total number of trees and mean tree size was detected. There were no trends over time in total number of deaths per plot or in size distributions of dead trees. Kolmogorov-Smirnov tests showed no differences in size class distributions for living trees through time. The size distribution of dead trees was significantly different from the size distribution of all trees present on the plots. Overall, the number of dead trees was low in small size classes, reached a peak value when canopy area was 20 - 30 m(2), and declined in lamer size-classes. Mortality as a ratio of dead vs. total trees peaked at intermediate canopy sizes too. Conclusion: A. erioloba mortality was size-dependent, peaking at intermediate sizes. The mortality distribution differs from all other tree mortality distributions recorded thus far. We suggest that a possible mechanism for this unusual mortality distribution is intraspecific competition for water in this semi-arid environment.
Plant phenolic compounds are known to interact with proteins producing changes in the food (e.g., biological value (BV), color, taste). Therefore, the in vivo relevance, especially, of covalent phenolprotein reactions on protein quality was studied in a rat bioassay. The rats were fed protein derivatives at a 10% protein level. Soy proteins were derivatized with chlorogenic acid and quercetin (derivatization levels: 0.056 and 0.28 mmol phenolic compound/gram protein). Analysis of nitrogen in diets, urine, and fecal samples as well as the distribution of amino acids were determined. Depending on the degree of derivatization, the rats fed with soy protein derivatives showed an increased excretion of fecal and urinary nitrogen. As a result, true nitrogen digestibility, BV, and net protein utilization were adversely affected. Protein digestibility corrected amino acid score was decreased for lysine, tryptophan, and sulfur containing amino acids.
The noncovalent binding of selected phenolic compounds (chlorogenic-, ferutic-, gallic acid, quercetin, rutin, and isoquercetin) to proteins (HSA, BSA, soy glycinin, and lysozyme) was studied by an indirect method applying the quenching of intrinsic tryptophan fluorescence. From the data obtained, the binding constants were calculated by nonlinear regression (one site binding; y = Bx/k + x). It has been reported that tannins inhibit human salivary amylase and that these complexes may reduce the development of cariogenic plaques. Further, amylase contains two tryptophan residues in its active site. Therefore, in a second part of the study involving 31 human subjects, evidence was sought for noncovalent interactions between the phenols of green tea and saliva proteins as measured by the fluorescence intensity. Amylase activity was determined before and after the addition of green tea to saliva of 31 subjects. Forty percent of the subjects showed an increase in amylase activity contrary to studies reporting only a decrease in activity. The interactions of tannin with amylase result in a decrease of its activity. It still remains to be elucidated why amylase does not react uniformly under conditions of applying green tea to saliva. Further, in terms of using phenols as caries inhibitors this finding should be of importance.
The mildly peraluminous granite of Seiffen, in the eastern Erzgebirge of Germany, is exposed by drillcores and associated with an abandoned Sri mine. The granite is of Stefanian age, with overlapping Th-U-total Pb monazite (302 +/- 4 Ma) and K-Ar siderophyllite ages (301 +/- 5 Ma). It is among the youngest granites in the Erzgebirge, emplaced in an extensional setting. The medium-grained, equigranular granite classifies as high-F, low-P Li-mica granite of A-type affinity. It is spatially associated with a high-Si rhyolitic microgranite, documenting the shallow intrusion level of this igneous association. Zircon, monazite-(Ce), and xenotime-(Y) constitute important radioactive accessory minerals in the granite, hosting the major proportions (> 80-90%) of the bulk-rock budgets of the REE, Y, and Th. A significant percentage of U (40-50%) may reside within unidentified phases or precipitated along grain boundaries. The most uncommon accessory phase is late-magmatic ytterbian xenotime-(Y) containing up to 11.2 wt% Yb2O3, in addition to 7.3 wt% Er2O3 and 7.9 wt% Dy2O3. The Seiffen granite (epsilon(Nd(300)) = -4.6) is geochemically evolved and rich in Sri (23-63 ppm) and W (11-14 ppm). It contains elevated to high concentrations of incompatible lithophile elements such as F, Li, Ga, Rb, Y, Nb, Cs, REE, Th, and U, thus having much in common chemically with subvolcanic ongonites. The most prominent compositional feature is the strong enrichment (in ppm) in Be (51-55) and Ta (23-28). The granite exhibits flat chondrite-normalized REE patterns (La-N/Lu-N = 1.35-1.48) and a moderate negative Eu anomaly (Eu/Eu* = 0.12-0.13). Indications for alteration-induced, postmagmatic disturbances of initial elemental abundances are weak and mainly relate to the ore-forming elements Sri and U.
We develop a model of stochastic radiation pressure for rotating non-spherical particles and apply the model to circumplanetary dynamics of dust grains. The stochastic properties of the radiation pressure are related to the ensemble-averaged characteristics of the rotating particles, which are given in terms of the rotational time-correlation function of a grain. We investigate the model analytically and show that an ensemble of particle trajectories demonstrates a diffusion-like behaviour. The analytical results are compared with numerical simulations, performed for the motion of the dusty ejecta from Deimos in orbit around Mars. We find that the theoretical predictions are in a good agreement with the simulation results. The agreement however deteriorates at later time, when the impact of non-linear terms, neglected in the analytic approach, becomes significant. Our results indicate that the stochastic modulation of the radiation pressure can play an important role in the circumplanetary dynamics of dust and may in case of some dusty systems noticeably alter an optical depth. (c) 2006 Elsevier Ltd. All rights reserved.
Questions of identity and provenance of minerals that are parts of masterpieces in museums have become increasingly important in mineralogical and historical studies. Detailed investigations of valuable and unique objects require on-site, nondestructive and noninvasive methods because touching or removing them may cause irreparable damage. A mobile Raman-microprobe has been used to meet these demands for truly in situ mineralogical studies of the large collection of minerals and rocks of the Prussian kings in the Grotto Hall (Grottensaal) of the New Palace (Neues Palais), Park Sanssouci in Potsdam. Minerals on the walls of the Grotto Hall were analyzed to identify them and thereby to complete the data bank of the collection. Fluid and solid inclusions in the interior of a large quartz crystal have been studied to provide evidence of the provenance of the crystal. The fluid inclusions contain aqueous saline solutions, whereas the solid inclusions are needles of anhydrite with a length of about 1.5 mm. The quartz probably originated from an area in the eastern Alps, from the surroundings of Bad Gastein, Austria. This is the first on-site and in situ study of inclusions below the surface of a mineral with a mobile Raman-microprobe outside a laboratory.
Fractional crystallization of peraluminous F- and H(2)O-rich granite magmas progressively enriches the remaining melt with volatiles. We show that, at saturation, the melt may separate into two immiscible conjugate melt fractions, one of the fractions shows increasing peraluminosity and the other increasing peralkalinity. These melt fractions also fractionate the incompatible elements to significantly different degrees. Coexisting melt fractions have differing chemical and physical properties and, due to their high density and viscosity contrasts, they will tend to separate readily from each other. Once separated, each melt fraction evolves independently in response to changing T/P/X conditions and further immiscibility events may occur, each generating its own conjugate pair of melt fractions. The strongly peralkaline melt fractions in particular are very reactive and commonly react until equilibrium is attained. Consequently, the peralkaline melt fraction is commonly preserved only in the isolated melt and mineral inclusions. We demonstrate that the differences between melt fractions that can be seen most clearly in differing melt inclusion compositions are also visible in the composition of the resulting ore-forming and accessory minerals, and are visible on scales from a few micrometers to hundreds of meters.
The velocity distribution function of granular gases in the homogeneous cooling state as well as some heated granular gases decays for large velocities as f proportional to exp(-const x nu). That is, its high-energy tail is overpopulated as compared with the Maxwell distribution. At the present time, there is no theory to describe the influence of the tail on the kinetic characteristics of granular gases. We develop an approach to quantify the overpopulated tail and analyze its impact on granular gas properties, in particular on the cooling coefficient. We observe and explain anomalously slow relaxation of the velocity distribution function to its steady state.
The influence of branched poly(ethyleneimine) on the phase behavior of the system sodium dodecylsulfate/toluene-pentanol (1:1)/water has been studied. The isotropic microemulsions still exist when water is replaced with aqueous solutions of PEI (up to 30% in weight), but their stability is significantly influenced. From a polymer concentration of 20 wt%, the polymer enhances the solubilization of water in oil, changes the sign of the spontaneous curvature of the surfactant film, and induces an inversion of the microemulsion type from water-in-oil (L-2) to oil-in-water (L-1), by the formation of a bicontinuous channel. Further investigations show that the addition of polymer in the L-2 phase changes the droplet-droplet interactions as the conductivity drops and the percolation disappears. In the bicontinuous channel, higher viscosities can be detected, as well as a weak percolation followed by a steep increase of the conductivity, which can be related to evident structural changes in the system. DSC measurements allow then to follow the changes of the water properties in the system, from interfacial-water in the L-2 phase to free-water in the sponge-like phase. Finally, all the measurements performed permit to characterize the structural transitions in the system and to understand the role of the added polymer.
The nanostructuring of ORMOCER (R) to form inverse opals is described. For this purpose a polymer opal is used as a template and infiltrated with liquid ORMOCER (R). After photopolymerization of the resin the host opal is dissolved in tetrahydrofuran and an ORMOCER (R) inverse opal is obtained. It shows excellent periodicity (by SEM) and optical properties to reveal a high degree of face centered cubic order. This replication process leads to a nanostructured photonic crystal with the outstanding mechanical properties of ORMOCER (R) and high temperature stability up to 350 degrees C.
Lago Laja is a late Quaternary volcanic‐dammed lake located near the drainage divide of the south central Andes. Field observations, lake reflection seismic profiles, bathymetry, and remote sensing data reveal an active fault system that runs parallel to the volcanic arc along the axis of the Main Cordillera, the Lago Laja fault system (LLFS). Normal faults of this extensional system cut late Pleistocene volcanics, <7.1 ka still water lacustrine sediments, 6.3 ka pyroclastic deposits, and Holocene alluvial fans. We divide the LLFS in three segments on the basis of fault geometry, width, and slip magnitude. The underwater faults of the central segment in the lake's deepest part have the maximum Holocene vertical slip rate of >2.7 mm/yr. Since 7.1 ka, the LLFS accounts for ∼0.7% of arc‐normal extension at an average minimum rate of 1.2 mm/yr and strain rate of ∼10−14 s−1. Seismites and surface ruptures evidence M>6 paleoearthquakes. The Main Cordillera at ∼37°S is a large‐scale pop‐up structure uplifted by thrusting along its foothills. In this light, we interpret extension in the axial and highest part of the Andes as incipient synorogenic gravitational collapse in response to uplift and crustal thickening. Thermal weakening due to elevated heat flow and postglacial lithospheric rebound and unbending have probably contributed to the arc‐limited collapse and Holocene acceleration of deformation rates. The lack of significant strike‐slip offsets along the LLFS as well as along both foothills‐thrust systems at 37°S contrasts with the intra‐arc dextral fault zone south of 38°S. Regional structural data indicates that north of 38°S, diffusely distributed strain reflects low partitioning of oblique subduction, while to the south deformation is localized in a discrete strike‐slip fault zone along the volcanic arc, reflecting a higher degree of partitioning. We relate this strain partitioning gradient to favorable fault orientations in the fore arc north of the Arauco Peninsula, a major seismotectonic boundary.
Great apes are the closest living relatives of humans. Physiological similarities between great apes and humans provide clues to identify which biological features in humans are primitive or derived from great apes. Vitamin A (VA) and carotenoid metabolism have been only partially studied in great apes, and comparisons between great apes and humans are not available. We aimed to investigate VA and carotenoid intake and plasma concentrations in great apes living in captivity, and to compare them to healthy humans. Dietary intakes of humans (n = 20) and, among the great apes, chimpanzees (n = 15) and orangutans (n = 5) were calculated. Plasma retinol (ROH), retinol-binding protein (RBP), retinyl esters, and major carotenoids were analyzed. The great ape diet was higher in VA than in humans, due to high intake of provitamin A carotenoids. Plasma ROH concentrations in great apes were similar to those in humans, but retinyl esters were higher in great apes than in humans. Differences in plasma carotenoid concentrations were observed between great apes and humans. Lutein was the main carotenoid in great apes, while P-carotene was the main carotenoid for humans. RBP concentrations did not differ between great apes and humans. The molar ratio of ROH to RBP was close to 1.0 in both great apes and humans. In conclusion, great apes show homeostatic ROH regulation, with high but physiological retinyl esters circulating in plasma. Furthermore, great apes show great selectivity in their plasmatic carotenoid concentration, which is not explained by dietary intake.
Context. Very massive stars pass through the Wolf-Rayet (WR) stage before they finally explode. Details of their evolution have not yet been safely established, and their physics are not well understood. Their spectral analysis requires adequate model atmospheres, which have been developed step by step during the past decades and account in their recent version for line blanketing by the millions of lines from iron and iron-group elements. However, only very few WN stars have been re-analyzed by means of line-blanketed models yet. Aims. The quantitative spectral analysis of a large sample of Galactic WN stars with the most advanced generation of model atmospheres should provide an empirical basis for various studies about the origin, evolution, and physics of the Wolf-Rayet stars and their powerful winds. Methods. We analyze a large sample of Galactic WN stars by means of the Potsdam Wolf-Rayet (PoWR) model atmospheres, which account for iron line blanketing and clumping. The results are compared with a synthetic population, generated from the Geneva tracks for massive star evolution. Results. We obtain a homogeneous set of stellar and atmospheric parameters for the GalacticWN stars, partly revising earlier results. Conclusions. Comparing the results of our spectral analyses of the Galactic WN stars with the predictions of the Geneva evolutionary calculations, we conclude that there is rough qualitative agreement. However, the quantitative discrepancies are still severe, and there is no preference for the tracks that account for the effects of rotation. It seems that the evolution of massive stars is still not satisfactorily understood.
Cave animals are widely recognised as model organisms to study regressive evolutionary processes like the reduction of eyes. In this paper, we report on the regressive evolution of species discrimination in the cave molly, Poecilia mexicana, which, unlike other cave fishes, still has functional eyes. This allowed us to examine the response to both visual and non-visual cues involved in species discrimination. When surface-dwelling females were given a chance to associate with either a conspecific or a swordtail (Xiphophorus hellerii) female, they strongly preferred the conspecific female both when multiple cues and when solely visual cues were available to the female. No association preference was observed when only non-visual cues were provided. In contrast, cave-dwelling females showed no preference under all testing conditions, suggesting that species recognition mechanisms have been reduced. We discuss the role of species discrimination in relation to habitat differences.
A cysteine mutant of a monomeric human Cu, Zn-SOD (Glycine 61, Serine 142) has been immobilized directly on gold electrodes using the thiol groups introduced. The electrochemical behavior of the surface confined protein was studied in mixtures of aqueous buffer and DMSO up to an organic solvent content of 60%. The formal potential was found to be rather independent of the DMSO content. However, half peak width increased and the redoxactive amount clearly decreased with raising DMSO content. In addition, the kinetics of the heterogeneous electron transfer became slower; but still a quasireversible electrochemical conversion of the mutant SOD was feasible. Thus, the electrodes were applied for sensorial superoxide detection. At a potential of +220 mV vs. Ag/AgCl advantage was taken of the partial oxidation reaction of the enzyme. A defined superoxide signal was obtained in solutions up to 40% DMSO. The sensitivity of the mutant electrodes decreased linearly with the organic solvent content in solution but was still higher compared to conventional cyt.c based sensors. At DMSO concentrations higher than 40% no sensor response was detected.
Water-soluble, amphiphilic diblock copolymers were synthesized by reversible addition fragmentation chain transfer polymerization. They consist of poly(butyl acrylate) as hydrophobic block with a low glass transition temperature and three different nonionic water-soluble blocks, namely, the classical hydrophilic block poly(dimethylacrylamide), the strongly hydrophilic poly(acryloyloxyethyl methylsulfoxide), and the thermally sensitive poly(N-acryloylpyrrolidine). Aqueous micellar solutions of the block copolymers were prepared and characterized by static and dynamic light scattering analysis (DLS and SLS). No critical micelle concentration could be detected. The micellization was thermodynamically favored, although kinetically slow, exhibiting a marked dependence on the preparation conditions. The polymers formed micelles with a hydrodynamic diameter from 20 to 100 nm, which were stable upon dilution. The micellar size was correlated with the composition of the block copolymers and their overall molar mass. The micelles formed with the two most hydrophilic blocks were particularly stable upon temperature cycles, whereas the thermally sensitive poly(N-acryloylpyrrolidine) block showed a temperature-induced precipitation. According to combined SLS and DLS analysis, the micelles exhibited an elongated shape such as rods or worms. It should be noted that the block copolymers with the most hydrophilic poly(sulfoxide) block formed inverse micelles in certain organic solvents.
Introduction to special issue: Dynamics of seismicity patterns and earthquake triggering - Preface
(2006)
Between reasoning
(2006)
In two experiments we investigated three-term reasoning with spatial relational assertions using the preposition between as compared to projective prepositions (such as to the left of). For each kind of assertion we distinguish the referent expression (i.e., the grammatical subject) from the relatum expression (i.e., the internal argument of the preposition; e.g., [The hedgehog](referent)_(expression) is to the left of [the frog](relatum)_(expression); [the snake](referent)_(expression) is between [the donkey and the deer](relatum)_(expression)). Previous research has shown that integrating premises with projective prepositions is easier (a) when the relatum expression of the second premise denotes an element already given by the first premise (relatum = given), and (b) when the term denoting a given element precedes the term denoting a new element (given - new). Experiment 1 extended this finding to second premises with the preposition between. In Experiment 2, between figured in the first premise. In this case, participants built an initial preferred model already from the first premise, although such a premise is indeterminate with respect to the array that it describes. Since there is no need left for integrating the second premise, this premise is instead used to verify the initial model and to modify it when necessary. A further investigation of conclusion evaluation times showed that conclusions were evaluated faster when they first mentioned the element that was included most recently into the mental model of the premises. The use of premises with between permitted the separation of recency of model inclusion from recency of appearance of an element in a premise.
A time-staggered semi-Lagrangian discretization of the rotating shallow-water equations is proposed and analysed. Application of regularization to the geopotential field used in the momentum equations leads to an unconditionally stable scheme. The analysis, together with a fully nonlinear example application, suggests that this approach is a promising, efficient, and accurate alternative to traditional schemes.
Three methods for the determination of the surface tension of liquids based on force measurements namely, the vertical plate method of Wilhelmy, the frame method of Lenard and the ring method of du Nouy are compared and studied in respect of a common principle of correction. It is shown that these three most important force-based methods allow the determination of the surface tension under static conditions. The force components of the corresponding liquid column below the measuring wire obtained for the straight part of the withdrawal curve up to the transition in its curved part provides exact surface tension values. The experimentally accessible value of the force component describes the physical background of the measured value correction contrary to the approximate equations obtained by mathematical way. Usually the determination of surface tension of liquids is based merely at the vertical plate method on exact equations thermodynamically derived whereas in the case of the frame and ring methods correction factors in approximate equations are used. At usual application of the force-based methods under the non-static condition of the withdrawal of a liquid column, the force maximum measured at withdrawal of the measuring object (plate, frame, or ring) is the basis for the determination of surface tension. In these cases, the measured surface tension values are compensated by correction equations for the frame and ring methods which are based on an correction factor and correction tables empirically obtained. The surface tension values obtained in this usual way agree with those obtained by using the force component of the corresponding liquid column below the measuring wire for the straight part of the withdrawal curve up to the transition in its curved part. Problems arising at the force measurements with increasing thickness of the measuring wires inside and outside the rings are discussed.
In this study we present iterative regularization methods using rational approximations, in particular, Pade approximants, which work well for ill-posed problems. We prove that the (k,j)-Pade method is a convergent and order optimal iterative regularization method in using the discrepancy principle of Morozov. Furthermore, we present a hybrid Pade method, compare it with other well-known methods and found that it is faster than the Landweber method. It is worth mentioning that this study is a completion of the paper [A. Kirsche, C. Bockmann, Rational approximations for ill-conditioned equation systems, Appl. Math. Comput. 171 (2005) 385-397] where this method was treated to solve ill-conditioned equation systems. (c) 2006 Elsevier Inc. All rights reserved.
Successful pain treatment in arthropathic lower extremities by acupuncture in haemophilia patients
(2006)
Acupuncture is successfully used in the treatment of degenerative osteoarthritis. The treatment of haemophilic arthropathies can require strong painkillers with severe side-effects. Therefore, a special yet simple acupuncture technique was evaluated in the treatment of these joint problems. Twelve patients with a factor VIII activity < 1% and at least one painful arthropathy in both lower extremities were included in this single-blinded study. The non-treated side served as a control. Treatment was assessed by a visual analogue scale (VAS) and an orthopaedic clinical examination. Only one needle was inserted at the rear fontanelle once per week and in 15 cycles. Ten of 12 patients showed an improvement of their pain perception. The average VAS could be reduced from 6.8 to 5.0. The side not receiving treatment showed a reduction from 4.1 to 4.0. No side-effects were observed. Even though interpretation of our data are limited due to the small patient numbers, significant improvement of the VAS after treatment suggests that acupuncture has a measurable positive effect in pain management for haemophilic arthropathy of the lower extremities.
Seasonal, host sex and age-related variations in helminth egg and coccidian oocyst counts were investigated in a naturally infected wild bushbuck (Tragelaphus scriptus) population in Queen Elizabeth National Park, western Uganda from April 2000 to February 2002. The prevalence and mean intensity quantified as the number of eggs and oocysts per gram of faeces were taken as a measure of parasite burdens. Host sex and age-related differences in prevalence values were not found but the overall prevalence of Eimeria sp. was significantly higher during the rainy season, and peak counts were recorded either during or soon after a peak rainfall. A similar trend was observed for Moniezia spp., although the results were marginally not significant. There were also no significant differences in mean intensity values, relative to host sex, age or season.
Incremental Support Vector Machines (SVM) are instrumental in practical applications of online learning. This work focuses on the design and analysis of efficient incremental SVM learning, with the aim of providing a fast, numerically stable and robust implementation. A detailed analysis of convergence and of algorithmic complexity of incremental SVM learning is carried out. Based on this analysis, a new design of storage and numerical operations is proposed, which speeds up the training of an incremental SVM by a factor of 5 to 20. The performance of the new algorithm is demonstrated in two scenarios: learning with limited resources and active learning. Various applications of the algorithm, such as in drug discovery, online monitoring of industrial devices and and surveillance of network traffic, can be foreseen.
Reliable information on small- and medium-sized enterprises (SMEs) is rare and costly for financial intermediaries. Therefore relationship banking is often considered as the appropriate lending technique. In this paper we offer a theoretical model to analyze relationship banking and the pricing behavior of banks in a Bertrand competition framework with monitoring costs. We show that the lack of reliable information leads to comparable high interest rates even if a long-term relationship between borrower and bank exists. The paper offers a theoretical explanation why SMEs often are faced with borrowing constraints.
[ 1] In this paper, we discuss the origin of superswell volcanism on the basis of representation and analysis of recent gravity and magnetic satellite data with wavelets in spherical geometry. We computed a refined gravity field in the south central Pacific based on the GRACE satellite GGM02S global gravity field and the KMS02 altimetric grid, and a magnetic anomaly field based on CHAMP data. The magnetic anomalies are marked by the magnetic lineation of the seafloor spreading and by a strong anomaly in the Tuamotu region, which we interpret as evidence for crustal thickening. We interpret our gravity field through a continuous wavelet analysis that allows to get a first idea of the internal density distribution. We also compute the continuous wavelet analysis of the bathymetric contribution to discriminate between deep and superficial sources. According to the gravity signature of the different chains as revealed by our analysis, various processes are at the origin of the volcanism in French Polynesia. As evidence, we show a large-scale anomaly over the Society Islands that we interpret as the gravity signature of a deeply anchored mantle plume. The gravity signature of the Cook-Austral chain indicates a complex origin which may involve deep processes. Finally, we discuss the particular location of the Marquesas chain as suggesting that the origin of the volcanism may interfere with secondary convection rolls or may be controlled by lithospheric weakness due to the regional stress field, or else related to the presence of the nearby Tuamotu plateau.
We introduce a method for computing instantaneous-polarization attributes from multicomponent signals. This is an improvement on the standard covariance method (SCM) because it does not depend on the window size used to compute the standard covariance matrix. We overcome the window-size problem by deriving an approximate analytical formula for the cross-energy matrix in which we automatically and adaptively determine the time window. The proposed method uses polarization analysis as applied to multicomponent seismic by waveform separation and filtering.
Dynamic service adaptation
(2006)
Change can be observed in our environment and in the technology we build. While changes in the environment happen continuously and implicitly, our technology has to be kept in sync with the changing world around it. Although we can prepare for some of the changes for most of them we cannot. This is especially true for next-generation mobile communication systems that are expected to support the creation of a ubiquitous society where virtually everything is connected and made available within an organic information network. Resources will frequently join or leave the network, new types of media or new combinations of existing types will be used to interact and cooperate, and services will be tailored to preferences and needs of individual customers to better meet their needs. This paper outlines our research in the area of dynamic service adaptation to provide concepts and technologies allowing for such environments. Copyright (C) 2006 John Wiley & Sons, Ltd.
Background: The biological interpretation of large-scale gene expression data is one of the paramount challenges in current bioinformatics. In particular, placing the results in the context of other available functional genomics data, such as existing bio-ontologies, has already provided substantial improvement for detecting and categorizing genes of interest. One common approach is to look for functional annotations that are significantly enriched within a group or cluster of genes, as compared to a reference group. Results: In this work, we suggest the information-theoretic concept of mutual information to investigate the relationship between groups of genes, as given by data-driven clustering, and their respective functional categories. Drawing upon related approaches (Gibbons and Roth, Genome Research 12: 1574-1581, 2002), we seek to quantify to what extent individual attributes are sufficient to characterize a given group or cluster of genes. Conclusion: We show that the mutual information provides a systematic framework to assess the relationship between groups or clusters of genes and their functional annotations in a quantitative way. Within this framework, the mutual information allows us to address and incorporate several important issues, such as the interdependence of functional annotations and combinatorial combinations of attributes. It thus supplements and extends the conventional search for overrepresented attributes within a group or cluster of genes. In particular taking combinations of attributes into account, the mutual information opens the way to uncover specific functional descriptions of a group of genes or clustering result. All datasets and functional annotations used in this study are publicly available. All scripts used in the analysis are provided as additional files.
Recurrence plot analyses suggest a novel reference system involved in newborn spontaneous movements
(2006)
The movements of newborns have been thoroughly studied in terms of reflexes, muscle synergies, leg coordination, and target-directed arm/hand movements. Since these approaches have concentrated mainly on separate accomplishments, there has remained a clear need for more integrated investigations. Here, we report an inquiry in which we explicitly concentrated on taking such a perspective and, additionally, were guided by the methodological concept of home base behavior, which Ilan Golard developed for studies of exploratory behavior in animals. Methods from nonlinear dynamics, such as symbolic dynamics and recurrence plot analyses of kinematic data received from audiovisual newborn recordings, yielded new insights into the spatial and temporal organization of limb movements. In the framework of home base behavior, our approach uncovered a novel reference system of spontaneous newborn movements.
The fabrication of compartmented micellar systems is an exciting new area of research in the field of polymer self-assembly. Multicompartment micelles composed of a water-soluble shell and a segregated hydrophobic core can be obtained via direct aqueous self-assembly of preformed polymeric amphiphiles possessing one hydrophilic segment and two incompatible hydrophobic segments (e.g. hydrocarbon and fluorocarbon blocks). Such macromolecular building-blocks were prepared in the present work principally via reversible addition-fragmentation transfer polymerization (RAFT). Polysoaps or triblock macrosurfactants can be synthesized in high yields by RAFT under relatively straightforward experimental conditions.
The AtNFXL1 gene encodes a NF-X1 type zinc finger protein required for growth under salt stress
(2006)
The human NF-X1 protein and homologous proteins in eukaryotes represent a class of transcription factors which are characterised. by NF-X1 type zinc finger motifs. The Arabidopsis genome encodes two NF-X1 homologs, which we termed AtNFXL1 and AtNFXL2. Growth and survival was impaired in atnfxl1 knock-out mutants and AtNFXL1-antisense plants under salt stress in comparison to wild-type plants. In contrast, 35S: :AtNFXL1 plants showed higher survival rates. The AtNFXL2 protein potentially plays an antagonistic role. The Arabidopsis NF-X1 type zinc finger proteins likely are part of regulatory mechanisms, which protect major processes such as photosynthesis.
The efficient time integration of the dynamic core equations for numerical weather prediction (NWP) remains a key challenge. One of the most popular methods is currently provided by implementations of the semi-implicit semi-Lagrangian (SISL) method, originally proposed by Robert (J. Meteorol. Soc. Jpn., 1982). Practical implementations of the SISL method are, however, not without certain shortcomings with regard to accuracy, conservation properties and stability. Based on recent work by Gottwald, Frank and Reich (LNCSE, Springer, 2002), Frank, Reich, Staniforth, White and Wood (Atm. Sci. Lett., 2005) and Wood, Staniforth and Reich (Atm. Sci. Lett., 2006) we propose an alternative semi-Lagrangian implementation based on a set of regularized equations and the popular Stormer-Verlet time stepping method in the context of the shallow-water equations (SWEs). Ultimately, the goal is to develop practical implementations for the 3D Euler equations that overcome some or all shortcomings of current SISL implementations.
Sexual dimorphism is expressed as median of the female values in percent of the median of the male values, of 4 length measurements, 3 circumferences, and 5 measurements of corpulence respectively fat. Data were obtained from a cross-sectional sample of more than 41.000 German subjects, aged from birth to age 62. The pattern of sexual dimorphism is similar in the length measurements. Girls are shorter at birth, but they increase in length at higher rates than boys and even temporarily overgrow the boys up to age 12. Thereafter, males show an obvious growth advantage leading to some 6 to 9% more length in adult males. In contrast, female circumferences are always smaller, from birth to senescence. Though, the differences between the sexes are low in circumferences, up to age 13, sexual dimorphism increases to 17% in the thoracic circumference at adulthood. Sexual dimorphism in weight and BMI is comparably with that in length measurements while subcutaneous fat and total body fat content are always higher in females. The results highlight that sexual dimorphism develops at different pace in the various components of the body and that it associates with a sex specific growth tempo.
Experimental results show that the polymerization of pyrrole in the presence of beta-naphthalenesulfonic acid and different fluorosurfactants like perfluorooctanesulfonic acid, perfluorooctyldiethanolamide, and ammonium perfluorooctanoate leads to polypyrrole with special morphologies, such as rings or disks and rectangular frames or plates. The formation of these unusually shaped particles of polymer dispersions is explained by the chemical and colloidal peculiarities of the oxidative pyrrole polymerization with ammonium peroxodisulfate in aqueous medium.
Hypersubstitutions are mappings which map operation symbols to terms. Terms can be visualized by trees. Hypersubstitutions can be extended to mappings defined on sets of trees. The nodes of the trees, describing terms, are labelled by operation symbols and by colors, i.e. certain positive integers. We are interested in mappings which map differently-colored operation symbols to different terms. In this paper we extend the theory of hypersubstitutions and solid varieties to multi-hypersubstitutions and colored solid varieties. We develop the interconnections between such colored terms and multihypersubstitutions and the equational theory of Universal Algebra. The collection of all varieties of a given type forms a complete lattice which is very complex and difficult to study; multi-hypersubstitutions and colored solid varieties offer a new method to study complete sublattices of this lattice.
Iterated finite state sequential transducers are considered as language generating devices. The hierarchy induced by the size of the state alphabet is proved to collapse to the fourth level. The corresponding language families are related to the families of languages generated by Lindenmayer systems and Chomsky grammars. Finally, some results on deterministic and extended iterated finite state transducers are established.
Leech et al. [Mary L. Leech, S. Singh, A.K. Jain, Simon L. Klemperer and R.M. Manickavasagam, Earth and Planetary Science Letters 234 (2005) 83-97], present 3 clusters of ages for growth stages in zircon from quartzo- feldspathic gneisses hosting coesite-bearing eclogite from the Tso Morari Complex, NW India. These age clusters, from oldest to youngest, are interpreted to represent the age of ultrahigh-pressure metamorphism, a subsequent eclogite facies overprint and a later amphibolite facies retrogression and require subduction of Indian crust to have started earlier than previously accepted. However, no petrographic evidence, such as inclusions in the zircons relating to particular metamorphic events, is presented to substantiate the proposed sequence of metamorphic stages. Previously published data from eclogites of the same area indicate that coesite-eclogite is not the first but at least the second eclogite facies stage. In addition, the newly proposed time interval between coesite-eclogite and the amphibolite facies overprint is longer than previously indicated by diffusion modelling of natural garnet-garnet couples in eclogite. Neither the age of ultrahigh-pressure metamorphism nor the timing of initiation of subduction is reliably constrained by the presented data
Magmatic and metamorphic zircons have been dated from ductilely deformed gabbroic dykes defining a dyke swarm and signifying crustal extension in the northern part of the Hengshan Complex of the North China Craton, These dykes now occur as boudins and deformed sheets within migmatitic tonalitic, trondhjemitic, granodioritic and granitic gneisses and are conspicuous due to relics of high-pressure granulite or even former eclogite facies garnet + pyroxene-bearing assemblages. SHRIMP ages for magmatic zircons from two dykes reflect the time of dyke emplacement at similar to 1915 Ma, whereas metamorphic zircons dated by both SHRIMP and evaporation techniques are consistently in the range 1848-1888 Ma. The Youngest granitoid gneiss yet dated in the Hengshan has an emplacement age of 18 2 17 Ma. These results complement recent geochronological studies from the neighbouring Wutai and Fuping Complexes, to the SE of the Hengshan, showing that a crustal extension event Occurred in the late Palaeoproterozoic. This preceded a major high-pressure collision- type metamorphic event in the central part of the North China Craton that occurred in the Palaeoproterozoic and not in the late Archaean as previously thought. Our data support recent suggestions that the North China Craton experienced a major, craton-wide orogenic event in the late Palaeoproterozoic after which it became cratonized and acted as a stable block.
The type-locality granulites from the Granulitgebirge of Saxony, Germany, are rocks of broadly granitic composition containing minor garnet and kyanite within a commonly mylonitised matrix of feldspars and quartz. Petrographic evidence indicates a primary assemblage of ternary feldspar + quartz + garnet + kyanite + rutile, most likely resulting from partial melting of a granitic protolith, for which equilibrium temperature and pressure conditions of > 1000 degrees C and > 1.5 GPa have been deduced. These extreme (for crustal rocks) conditions, and the inferred peak assemblage, are supported by the newly-developed Zr-in-rutile geothermometer and experimental studies on the same bulk composition, respectively. As these conditions lie above those required for plagioclase stability in quartz tholeiites, they are thus in the eclogite facies. Widespread modification of the peak assemblage, for example mesoperthite formation after ternary feldspar, deformation-induced recrystallisation of perthites to two-feldspar + quartz aggregates, biotite replacing garnet, Ca-loss at garnet rims, sillimanite replacing kyanite or secondary garnet growth, makes reliable interpretation of equilibrium assemblages and compositions very difficult and explains the spread of published pressure- temperature values and consequent confusion about formation depths and the validity of tectonometamorphic models. Such extreme metamorphic conditions in rock compositions typical for the upper continental crust, reflecting a hot subduction environment, has important consequences for understanding some collisional orogens
Quantification of discrete pressure-temperature domains in deformed chlorite + white mica-bearing metapelites was undertaken on mineral compositions derived by two-dimensional microprobe compositional mapping of selected areas of rock thin sections. In order to achieve compositional information at sufficient analytical precision, spatial resolution and sample coverage within a typical analysis time of 1 day, an optimization of measurement methods was necessary. The method presented here allows collection of raw counts for eight different element concentrations at an analytical precision of similar to 1-2 wt%. X-ray intensity multiplane maps (one map per measured chemical element) are translated into concentration multiplane maps, utilizing selected conventionally measured spot analyses combined with the Castaing approximation for each mineral. As this step requires identification of the different minerals present in the mapped area, a statistical clustering technique to identify different groups of composition was developed, guided by simple petrographic inspection of the thin section, to delineate the important minerals in the mapped area. Finally, the compositions of each pixel are translated into a mineral structural formula thus yielding a new kind of image with a high content of petrological information. The reliability of the mineral composition images was emphasized by carrying out precision tests on the analytical data. The possible use of chemical maps to infer the P-T-deformation history of metamorphic rocks is illustrated with two samples from the Spitzbergen and the Sambagawa blueschist facies belts. In both samples, a strong correlation between structures and chemistry is observed. Qualitative estimates of P-T conditions from the Si-content of mica and chlorite are in good agreement with their location in microstructures that formed at different times. Therefore, the combination of chemical maps with microstructural observations is a very powerful approach to understand both the evolution of complex metamorphic rocks and the control by deformation of mineral reactivity.
Garnets in continentally derived high-pressure (HP) rocks of the Sesia Zone (Western Alps) exhibit three different chemical zonation patterns, depending on sample locality. Comparison of observed garnet zonation patterns with thermodynamically modelled patterns shows that the different patterns are caused by differences in the water content of the subducted protoliths during prograde metamorphism. Zonation patterns of garnets in water-saturated host rocks show typical prograde chemical zonations with steadily increasing pyrope content and increasing XMg, together with bell-shaped spessartine patterns. In contrast, garnets in water-undersaturated rocks have more complex zonation patterns with a characteristic decrease in pyrope and XMg between core and inner rim. In some cases, garnets show an abrupt compositional change in core-to-rim profiles, possibly due to water-undersaturation prior to HP metamorphism. Garnets from both water-saturated and water-undersaturated rocks show signs of intervening growth interruptions and core resorption. This growth interruption results from bulk-rock depletion caused by fractional garnet crystallization. The water content during burial influences significantly the physical properties of the subducted rocks. Due to enhanced garnet crystallization, water-undersaturated rocks, i.e. those lacking a free fluid phase, become denser than their water-saturated equivalents, facilitating the subduction of continental material. Although water-bearing phases such as phengite and epidote are stable up to eclogite-facies conditions in these rocks, dehydration reactions during subduction are lacking in water-undersaturated rocks up to the transition to the eclogite facies, due to the thermodynamic stability of such hydrous phases at high P-T conditions. Our calculations show that garnet zonation patterns strongly depend on the mineral parageneses stable during garnet growth and that certain co-genetic mineral assemblages cause distinct garnet zonation patterns. This observation enables interpretation of complex garnet growth zonation patterns in terms of garnet-forming reactions and water content during HP metamorphism, as well determination of detailed P-T paths.