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Just after the publication of the Theory of Communicative Action in 1981, a new generation of interpreters started a different reception of Durkheim in Germany. Hans-Peter Müller, sociologist and editor of the German translation of Leçons de sociologie, reconstructs the history of the German Durkheim’s Reception and illuminates the reasons for his interest in the French sociologist. He delivers different insights into the background which permitted the post-Habermasian generation to reach a new understanding of Durkheim’s work by enlightening the scientific and political conditions from which this new sensibility emerged.
The interview offers a reconstruction of the German reception of Durkheim since the middle of the 1970s. Hans Joas, who was one of its major protagonists, discusses the backdrop that finally permitted a scholarly examination of Durkheim’s sociology in Germany. Focussing on his personal reception Joas then gives an account of the Durkheimian themes that inspire his work.
Short period double degenerate white dwarf (WD) binaries with periods of less than similar to 1 day are considered to be one of the likely progenitors of type Ia supernovae. These binaries have undergone a period of common envelope evolution. If the core ignites helium before the envelope is ejected, then a hot subdwarf remains prior to contracting into a WD. Here we present a comparison of two very rare systems that contain two hot subdwarfs in short period orbits. We provide a quantitative spectroscopic analysis of the systems using synthetic spectra from state-of-the-art non-LTE models to constrain the atmospheric parameters of the stars. We also use these models to determine the radial velocities, and thus calculate dynamical masses for the stars in each system.
In this paper, we consider counting and projected model counting of extensions in abstract argumentation for various semantics. When asking for projected counts we are interested in counting the number of extensions of a given argumentation framework while multiple extensions that are identical when restricted to the projected arguments count as only one projected extension. We establish classical complexity results and parameterized complexity results when the problems are parameterized by treewidth of the undirected argumentation graph. To obtain upper bounds for counting projected extensions, we introduce novel algorithms that exploit small treewidth of the undirected argumentation graph of the input instance by dynamic programming (DP). Our algorithms run in time double or triple exponential in the treewidth depending on the considered semantics. Finally, we take the exponential time hypothesis (ETH) into account and establish lower bounds of bounded treewidth algorithms for counting extensions and projected extension.
Skeletal muscle alterations during aging lead to dysfunctional metabolism, correlating with frailty and early mortality. The loss of proteostasis is a hallmark of aging. Whether proteostasis loss plays a role in muscle aging remains elusive. To address this question we collected muscles, Soleus (SOL, type I) and Extensor digitorum longus (EDL, type II), from young (4 months) and old (25 months) C57BL/6 mice and evaluated the proteasomal system. Initial work showed decreased 26 S activity in old SOL. EDL displayed lower proteasomal activity in both ages compared to any of the SOL ages. Moreover, in order to understand if during aging there is the so-called “fiber switch from fast-to-slow”, we performed western blots against sMHC and fMHC (slow and fast myosin heavy chain, respectively). Preliminary results suggest that young SOL is composed by slow twitch fibers but also contains fast twitch fibers, while young EDL seems to be mostly composed by fast twitch fibers that level down during aging, suggesting the switch. As a conclusion, EDL seems to have less proteasomal activity, however, if this is a contributor or a consequence to the muscle fiber switch during aging still needs further investigation.
The Internet can be considered as the most important infrastructure for modern society and businesses. A loss of Internet connectivity has strong negative financial impacts for businesses and economies. Therefore, assessing Internet connectivity, in particular beyond their own premises and area of direct control, is of growing importance in the face of potential failures, accidents, and malicious attacks. This paper presents CORIA, a software framework for an easy analysis of connectivity risks based on large network graphs. It provides researchers, risk analysts, network managers and security consultants with a tool to assess an organization's connectivity and paths options through the Internet backbone, including a user-friendly and insightful visual representation of results. CORIA is flexibly extensible in terms of novel data sets, graph metrics, and risk scores that enable further use cases. The performance of CORIA is evaluated by several experiments on the Internet graph and further randomly generated networks.
Introduction
(2016)
The Paris Agreement for Climate Change or the Sustainable Development Goals (SDGs) rely on new modes of governance for implementation. Indeed, new modes of governance such as market-based instruments, public-private partnerships or multi-stakeholder initiatives have been praised for playing a pivotal role in effective and legitimate sustainability governance. Yet, do they also deliver in areas of limited statehood? States such as Malaysia or the Dominican Republic partly lack the ability to implement and enforce rules; their statehood is limited. This introduction provides the analytical framework of this volume and critically examines the performance of new modes of governance in areas of limited statehood, drawing on the book’s in-depth case studies on issues of climate change, biodiversity, and health.
Conclusion
(2016)
This chapter revisits the role of the new modes of governance in areas of limited statehood. First, it states that there is no linear relationship between degrees of statehood and the overall effectiveness of new modes of sustainability governance. Second, the chapter states that, in most of the cases, national governments are hesitant or even actively hamper the development of new modes of governance. Third, it shows that the absence of the shadow of hierarchy can indeed lead to ineffective new modes of governance. However, the shadow of hierarchy does not necessarily need to be cast by states. Finally, the author reviews the complexities involved in participatory practices, stressing the importance of institutional structures and knowledgeable brokers. The chapter concludes by outlining fields for future research.
This chapter investigates the trajectory of establishing the Forest Stewardship Council (FSC) in the early 1990s as the first private transnational certification organization with an antagonistic stakeholder body. Its main contribution is a micro-analysis of the founding assembly in 1993. By investigating the role of brokers within the negotiation as one institutional scope condition for ‘arguing’ having occurred, the chapter adopts a dramaturgical approach. It contends that the authority of brokers is not necessarily institutionally given, but needs to be gained: brokers have to prove situationally that their knowledge is relevant and that they are speaking impartially in the interest of progress rather than their own. The chapter stresses the importance of procedural knowledge which brokers provide in contrast to policy knowledge.
Live migration is an important feature in modern software-defined datacenters and cloud computing environments. Dynamic resource management, load balance, power saving and fault tolerance are all dependent on the live migration feature. Despite the importance of live migration, the cost of live migration cannot be ignored and may result in service availability degradation. Live migration cost includes the migration time, downtime, CPU overhead, network and power consumption. There are many research articles that discuss the problem of live migration cost with different scopes like analyzing the cost and relate it to the parameters that control it, proposing new migration algorithms that minimize the cost and also predicting the migration cost. For the best of our knowledge, most of the papers that discuss the migration cost problem focus on open source hypervisors. For the research articles focus on VMware environments, none of the published articles proposed migration time, network overhead and power consumption modeling for single and multiple VMs live migration. In this paper, we propose empirical models for the live migration time, network overhead and power consumption for single and multiple VMs migration. The proposed models are obtained using a VMware based testbed.
The problem of atmospheric emission from OH molecules is a long standing problem for near-infrared astronomy. PRAXIS is a unique spectrograph which is fed by fibres that remove the OH background and is optimised specifically to benefit from OH-Suppression. The OH suppression is achieved with fibre Bragg gratings, which were tested successfully on the GNOSIS instrument. PRAXIS uses the same fibre Bragg gratings as GNOSIS in its first implementation, and will exploit new, cheaper and more efficient, multicore fibre Bragg gratings in the second implementation. The OH lines are suppressed by a factor of similar to 1000, and the expected increase in the signal-to-noise in the interline regions compared to GNOSIS is a factor of similar to 9 with the GNOSIS gratings and a factor of similar to 17 with the new gratings. PRAXIS will enable the full exploitation of OH suppression for the first time, which was not achieved by GNOSIS (a retrofit to an existing instrument that was not OH-Suppression optimised) due to high thermal emission, low spectrograph transmission and detector noise. PRAXIS has extremely low thermal emission, through the cooling of all significantly emitting parts, including the fore-optics, the fibre Bragg gratings, a long length of fibre, and the fibre slit, and an optical design that minimises leaks of thermal emission from outside the spectrograph. PRAXIS has low detector noise through the use of a Hawaii-2RG detector, and a high throughput through a efficient VPH based spectrograph. PRAXIS will determine the absolute level of the interline continuum and enable observations of individual objects via an IFU. In this paper we give a status update and report on acceptance tests.
‘Steadfast and unreserved’
(2023)
Development of a tool to identify intensive care patients at risk of meropenem therapy failure
(2018)
Preclinical assessment of penetration not only in intact, but also in barrier‐disrupted skin is important to explore the surplus value of novel drug delivery systems, which can be specifically designed for diseased skin. Here, we characterized physical and chemical barrier disruption protocols for short‐term ex vivo skin cultures with regard to structural integrity, physiological and biological parameters. Further, we compared the penetration of dexamethasone (Dex) in different nanoparticle‐based formulations in stratum corneum, epidermis and dermis extracts of intact vs. barrier‐disrupted skin as well as by dermal microdialysis at 6, 12 and 24 hours after topical application. Dex was quantified by liquid‐chromatography ‐ tandem‐mass spectrometry (LC‐MS/MS). Simultaneously, we investigated the Dex efficacy by interleukin (IL) analysis. Tape‐stripping (TS) and 4 hours sodium lauryl sulfate 5 % (SLS) exposure were identified as highly effective barrier disruption methods assessed by reproducible transepidermal water loss (TEWL) changes and IL‐6/8 increase which was more pronounced in SLS‐treated skin. The barrier state has also a significant impact on the Dex penetration kinetics: for all formulations, TS highly increased dermal Dex concentration despite the fact that nanocrystals quickly and effectively penetrated both, intact and barrier‐disrupted skin reaching significantly higher dermal Dex concentration after 6 hours compared to Dex cream. The surplus value of encapsulation in ethyl cellulose nanocarriers could mostly be observed when applied on intact skin, in general showing a delayed Dex penetration. Estimation of cytokines was limited due to the trauma caused by probe insertion. In summary, ex vivo human skin is a highly interesting short‐term preclinical model for the analysis of penetration and efficacy of novel drug delivery systems.
Direct visualization of APLP1 cell-cell adhesion platforms via fluorescence fluctuation spectroscopy
(2017)
The Amyloid-precursor-like protein 1 (APLP1) is a neuronal type I transmembrane protein which plays a role in synaptic adhesion and synaptogenesis. Past investigations indicated that APLP1 is involved in the formation of protein-protein complexes that bridge the junctions between neighboring cells. Nevertheless, APLP1-APLP1 trans interactions have never been directly observed in higher eukaryotic cells. Here, we investigate APLP1 interactions and dynamics directly in living human embryonic kidney (HEK) cells, using fluorescence fluctuation spectroscopy techniques, namely cross-correlation scanning fluorescence correlation spectroscopy (sFCS) and Number&Brightness (N&B). Our results show that APLP1 forms homotypic trans complexes at cell-cell contacts. In the presence of zinc ions, the protein forms macroscopic clusters, exhibiting an even higher degree of trans binding and strongly reduced dynamics. Further evidence from Giant Plasma Membrane Vesicles and live cell actin staining suggests that the presence of an intact cortical cytoskeleton is required for zinc-induced cis multimerization. Subsequently, large adhesion platforms bridging interacting cells are formed through APLP1-APLP1 direct trans interactions. Taken together, our results provide direct evidence that APLP1 functions as a neuronal zinc-dependent adhesion protein and provide a more detailed understanding of the molecular mechanisms driving the formation of APLP1 adhesion platforms. Further, they show that fluorescence fluctuation spectroscopy techniques are useful tools for the investigation of protein-protein interactions at cell-cell adhesion sites.
3D point cloud technology facilitates the automated and highly detailed digital acquisition of real-world environments such as assets, sites, cities, and countries; the acquired 3D point clouds represent an essential category of geodata used in a variety of geoinformation applications and systems. In this paper, we present a web-based system for the interactive and collaborative exploration and inspection of arbitrary large 3D point clouds. Our approach is based on standard WebGL on the client side and is able to render 3D point clouds with billions of points. It uses spatial data structures and level-of-detail representations to manage the 3D point cloud data and to deploy out-of-core and web-based rendering concepts. By providing functionality for both, thin-client and thick-client applications, the system scales for client devices that are vastly different in computing capabilities. Different 3D point-based rendering techniques and post-processing effects are provided to enable task-specific and data-specific filtering and highlighting, e.g., based on per-point surface categories or temporal information. A set of interaction techniques allows users to collaboratively work with the data, e.g., by measuring distances and areas, by annotating, or by selecting and extracting data subsets. Additional value is provided by the system's ability to display additional, context-providing geodata alongside 3D point clouds and to integrate task-specific processing and analysis operations. We have evaluated the presented techniques and the prototype system with different data sets from aerial, mobile, and terrestrial acquisition campaigns with up to 120 billion points to show their practicality and feasibility.
The problem of constructing and maintaining a tree topology in a distributed manner is a challenging task in WSNs. This is because the nodes have limited computational and memory resources and the network changes over time. We propose the Dynamic Gallager-Humblet-Spira (D-GHS) algorithm that builds and maintains a minimum spanning tree. To do so, we divide D-GHS into four phases, namely neighbor discovery, tree construction, data collection, and tree maintenance. In the neighbor discovery phase, the nodes collect information about their neighbors and the link quality. In the tree construction, D-GHS finds the minimum spanning tree by executing the Gallager-Humblet-Spira algorithm. In the data collection phase, the sink roots the minimum spanning tree at itself, and each node sends data packets. In the tree maintenance phase, the nodes repair the tree when communication failures occur. The emulation results show that D-GHS reduces the number of control messages and the energy consumption, at the cost of a slight increase in memory size and convergence time.
Mordecai (Son of Jair)
(2021)
Mordecai, son of Jair, is the Deuteragonist of the book of Esther. Some time after the death of the eponymous Esther’s parents, Mordecai – Esther’s cousin – becomes her guardian (Esth 2:7). The MT version of the book also has Mordecai adopting Esther as his daughter (Esth 2:7, 15). In LXX, on the other hand, Mordecai takes her as his wife (Esth 2:7; cf. bMeg 13a). Although the syntax of Esth 2:5–6 is convoluted, it appears Mordecai is a Benjaminite deportee from Jerusalem – exiled by Nebuchadnezzar, along with King Jeconiah and others. Presuming a coherent historical and chronological framework, this would make Mordecai 114 years old at the time of the events, at the very least, which does not accord with his depiction throughout the novella. (This biographical detail is absent in the Greek Alpha Text of Esther.)
Naomi
(2022)
Naomi is one of the dramatis personae of the book of Ruth, which is set by its author “in the days that the judges judged” (Ruth 1:1). She is introduced as wife of Elimelech and mother of Mahlon and Chilion, all of whom journeyed to Moab from Bethlehem, due to famine. By the fifth verse in the book’s first chapter, her husband and sons are dead, leaving Naomi with only her Moabite daughters-in-law, Orpah and Ruth (Ruth 1:1–5). Shortly thereafter, Orpah too exits the stage (Ruth 1:14). Against Naomi’s protestations, Ruth ties her own fate to her mother-in-law’s, joining Naomi on her journey back to Bethlehem (Ruth 1:4b, 8–19a).
Immune to COVID?
(2021)
BIOMEX (BIOlogy and Mars EXperiment) is an ESA/Roscosmos space exposure experiment housed within the exposure facility EXPOSE-R2 outside the Zvezda module on the International Space Station (ISS). The design of the multiuser facility supports-among others-the BIOMEX investigations into the stability and level of degradation of space-exposed biosignatures such as pigments, secondary metabolites, and cell surfaces in contact with a terrestrial and Mars analog mineral environment. In parallel, analysis on the viability of the investigated organisms has provided relevant data for evaluation of the habitability of Mars, for the limits of life, and for the likelihood of an interplanetary transfer of life (theory of lithopanspermia). In this project, lichens, archaea, bacteria, cyanobacteria, snow/permafrost algae, meristematic black fungi, and bryophytes from alpine and polar habitats were embedded, grown, and cultured on a mixture of martian and lunar regolith analogs or other terrestrial minerals. The organisms and regolith analogs and terrestrial mineral mixtures were then exposed to space and to simulated Mars-like conditions by way of the EXPOSE-R2 facility. In this special issue, we present the first set of data obtained in reference to our investigation into the habitability of Mars and limits of life. This project was initiated and implemented by the BIOMEX group, an international and interdisciplinary consortium of 30 institutes in 12 countries on 3 continents. Preflight tests for sample selection, results from ground-based simulation experiments, and the space experiments themselves are presented and include a complete overview of the scientific processes required for this space experiment and postflight analysis. The presented BIOMEX concept could be scaled up to future exposure experiments on the Moon and will serve as a pretest in low Earth orbit.
Stable covalently photo-cross-linked porous poly(ionic liquid) membrane with gradient pore size
(2018)
Porous polyelectrolyte membranes stable in a highly ionic environment are obtained by covalent crosslinking of an imidazolium-based poly(ionic liquid). The crosslinking reaction involves the UV light-induced thiol-ene (click) chemistry, and the phase separation, occurring during the crosslinking step, generates a fully interconnected porous structure in the membrane. The porosity is on the order of the micrometer scale and the membrane shows a gradient of pore size across the membrane cross-section. The membrane can separate polystyrene latex particles of different size and undergoes actuation in contact with acetone due to the asymmetric porous structure.
Pace-of-life syndromes
(2018)
This introduction to the topical collection on Pace-of-life syndromes: a framework for the adaptive integration of behaviour, physiology, and life history provides an overview of conceptual, theoretical, methodological, and empirical progress in research on pace-of-life syndromes (POLSs) over the last decade. The topical collection has two main goals. First, we briefly describe the history of POLS research and provide a refined definition of POLS that is applicable to various key levels of variation (genetic, individual, population, species). Second, we summarise the main lessons learned from current POLS research included in this topical collection. Based on an assessment of the current state of the theoretical foundations and the empirical support of the POLS hypothesis, we propose (i) conceptual refinements of theory, particularly with respect to the role of ecology in the evolution of (sexual dimorphism in) POLS, and (ii) methodological and statistical approaches to the study of POLS at all major levels of variation. This topical collection further holds (iii) key empirical examples demonstrating how POLS structures may be studied in wild populations of (non) human animals, and (iv) a modelling paper predicting POLS under various ecological conditions. Future POLS research will profit from the development of more explicit theoretical models and stringent empirical tests of model assumptions and predictions, increased focus on how ecology shapes (sex-specific) POLS structures at multiple hierarchical levels, and the usage of appropriate statistical tests and study designs. Significance statement As an introduction to the topical collection, we summarise current conceptual, theoretical, methodological and empirical progress in research on pace-of-life syndromes (POLSs), a framework for the adaptive integration of behaviour, physiology and life history at multiple hierarchical levels of variation (genetic, individual, population, species). Mixed empirical support of POLSs, particularly at the within-species level, calls for an evaluation and refinement of the hypothesis. We provide a refined definition of POLSs facilitating testable predictions. Future research on POLSs will profit from the development of more explicit theoretical models and stringent empirical tests of model assumptions and predictions, increased focus on how ecology shapes (sex-specific) POLSs structures at multiple hierarchical levels and the usage of appropriate statistical tests and study designs.
Various techniques are utilized by the seismological community, extractive industries, energy and geoengineering companies to identify earthquake nucleation processes in close proximity to engineering operation points. These operations may comprise fluid extraction or injections, artificial water reservoir impoundments, open pit and deep mining, deep geothermal power generations or carbon sequestration. In this letter to the editor, we outline several lines of investigation that we suggest to follow to address the discrimination problem between natural seismicity and seismic events induced or triggered by geoengineering activities. These suggestions have been developed by a group of experts during several meetings and workshops, and we feel that their publication as a summary report is helpful for the geoscientific community. Specific investigation procedures and discrimination approaches, on which our recommendations are based, are also published in this Special Issue (SI) of Journal of Seismology.
Business processes constantly generate, manipulate, and consume data that are managed by organizational databases. Despite being central to process modeling and execution, the link between processes and data is often handled by developers when the process is implemented, thus leaving the connection unexplored during the conceptual design. In this paper, we introduce, formalize, and evaluate a novel conceptual view that bridges the gap between process and data models, and show some kinds of interesting insights that can be derived from this novel proposal.