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- coloring agents (2)
- common ground (2)
- common ownership (2)
- common‐garden experiment (2)
- communities (2)
- comparison of devices (2)
- complex networks (2)
- composites (2)
- composition (2)
- comprehension (2)
- computer games (2)
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- confidence (2)
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- consequences (2)
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- continental lithosphere (2)
- continuity (2)
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- continuous time random walk (2)
- contract workers (2)
- contrast effect (2)
- conversational implicature (2)
- converting factor (2)
- cooperation (2)
- coordination (2)
- copper-related disorders (2)
- core PG1351 (2)
- cori cycle (2)
- coronary artery disease (2)
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- corporate citizenship (2)
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- cortisol (2)
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- critical solution temperature (2)
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- cropping system (2)
- cross ownership (2)
- crust (2)
- cryptic species complex (2)
- crystal orientation (2)
- cyanobacteria (2)
- cyanobacterial sucrose-phosphatase (2)
- cyber victimization (2)
- cyberbullying victimization (2)
- cysteine alkylation (2)
- dark triad (2)
- dark virus (2)
- data (2)
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- data fusion (2)
- data matching (2)
- data preparation (2)
- data processing (2)
- data sharing (2)
- data wrangling (2)
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- de novo genome assembly (2)
- decarbonization (2)
- decision-theory (2)
- decline (2)
- deep biosphere (2)
- deep-sea (2)
- deformation monitoring (2)
- dehydration (2)
- density (2)
- density functional theory (2)
- depressive-like behavior (2)
- derivation (2)
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- developmental dyslexia (2)
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- dietary restriction (2)
- diffraction (2)
- digital bathymetric model (2)
- digital health (2)
- digitalization (2)
- dimension independent bound (2)
- dimerization of 4-nitrothiophenol (2)
- disaster risk reduction (2)
- discrepancy principle (2)
- disease (2)
- diselenide (2)
- disorders (2)
- dispersal filtering (2)
- diversity climate (2)
- donor (2)
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- drought index (2)
- drug delivery system (2)
- dual GLP-1/glucagon receptor agonist (2)
- duplicate detection (2)
- dust (2)
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- dyadic coping (2)
- dynamic (2)
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- dynamical model (2)
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- dyslexia (2)
- e-z reader (2)
- early eocene (2)
- early warning (2)
- earth system model (2)
- earthquake (2)
- earthquake source observations (2)
- eastern continental Asia (2)
- eco-hydrology (2)
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- ecosystem services provisioning (2)
- edge computing (2)
- effectiveness (2)
- effects (2)
- efficiency (2)
- efficient (2)
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- electron-transfer (2)
- electropolymerization (2)
- emission factors (2)
- emotional difficulties (2)
- emotions (2)
- empirical mode decomposition (2)
- end-stage kidney disease (2)
- endotoxin (2)
- energy (2)
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- ensemble and time averaged mean squared displacement (2)
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- entropy production (2)
- enzyme (2)
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- episodic memory (2)
- equatorial electrojet (2)
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- equine (2)
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- error reduction (2)
- ethnic social capital (2)
- ethnic-racial identity (2)
- europe (2)
- european (2)
- evaluative study (2)
- evaporation (2)
- evaporites (2)
- event expectations (2)
- evidence (2)
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- excitonic materials (2)
- executive function (2)
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- exendin-4 (2)
- exercise intensity (2)
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- exhaustivity (2)
- existence (2)
- expanding medium (2)
- expectancies (2)
- experiences survey (2)
- experimental evidence (2)
- exploit (2)
- exploratory-behavior (2)
- exposed water ice (2)
- exposome (2)
- exposome‐ wide association study (2)
- expression patterns (2)
- external training load (2)
- externalization (2)
- extinction drivers (2)
- extinction event (2)
- extremal values (2)
- eye tracking (2)
- family farming (2)
- fastest first-passage time of N walkers (2)
- fault creep (2)
- feedback (2)
- feeding behaviour (2)
- ferroelectric polymers (2)
- fetal origins hypothesis (2)
- fiber actuators (2)
- field-aligned currents (2)
- filter (2)
- fine dining (2)
- firmware update (2)
- fitness (2)
- fitness consequences (2)
- fixation locations (2)
- flagellum (2)
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- floating mat (2)
- flood (2)
- flood recovery (2)
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- fluctuations (2)
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- fluorescence (2)
- fluorescence correlation spectroscopy (2)
- fluorescence microscopy (2)
- fluorinated organic spacer (2)
- flux tracking (2)
- focus group (2)
- food frequency questionnaire (2)
- forage availability (2)
- forage gaps (2)
- foraging (2)
- force (2)
- force profiles (2)
- forebrain (2)
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- formal verification (2)
- formate dehydrogenase (2)
- freshwater (2)
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- frictional properties (2)
- fsQCA (2)
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- functionalization (2)
- gait (2)
- gait analysis (2)
- galaxies (2)
- galaxies: high-redshift (2)
- gallbladder cancer (2)
- gamma rays: general (2)
- gamma-rays: general (2)
- gas phase electron spectroscopy (2)
- gate effect (2)
- gender stereotype trait (2)
- gene delivery (2)
- gene expression (2)
- generalized dissimilarity modelling (2)
- genetic differentiation (2)
- genetic diversity (2)
- genetic programming (2)
- genome-wide association (2)
- genotype (2)
- geochronology (2)
- geographic distribution (2)
- gestural organization (2)
- glacial maximum (2)
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- global mean temperature (2)
- global monsoon (2)
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- global warming (2)
- global warming levels (2)
- glucocorticoid receptor (2)
- glycogen (2)
- gold nanoparticle assembly (2)
- government (2)
- gradient boosting (2)
- gradient flow (2)
- grafted polymers (2)
- grain-size distribution (2)
- granulite (2)
- graph transformation systems (2)
- green polymers (2)
- greenland shelf (2)
- grief (2)
- ground-motion modelling (2)
- groundwater inflow (2)
- groundwater vulnerability (2)
- growth restriction (2)
- gulf coastal plain (2)
- gwas (2)
- habit formation (2)
- habituation (2)
- habituation-switch paradigm (2)
- handheld device (2)
- hanging wall (2)
- hate speech detection (2)
- haute cuisine (2)
- health risks (2)
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- heart failure (2)
- heat stress (2)
- heat stress memory (2)
- heat-stress (2)
- heavy precipitation (2)
- heme (2)
- hemoglobin amount (2)
- heterojunction silicon solar cells (2)
- heuristics (2)
- hierarchy-of-hypotheses approach (2)
- high dimensional (2)
- high gastronomy (2)
- high-resolution record (2)
- higher education management (2)
- high‐risk drinking (2)
- holocene (2)
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- hormones (2)
- host adaptation (2)
- household analysis (2)
- hsp70 (2)
- human endotoxemia (2)
- human motion (2)
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- human physical conditioning (2)
- human values (2)
- human-robot interaction (2)
- hybrid modelling (2)
- hydrological drought (2)
- hydrological models (2)
- hydrological signatures (2)
- hydroxyl-functional poly(2-vinyl pyridine) (2)
- hyperactivity (2)
- hyperbolic tilings (2)
- hyperthermia (2)
- ice absorption features (2)
- ice sheet (2)
- ideal-observer model (2)
- identifying influential nodes (2)
- identity (2)
- identity development (2)
- image processing (2)
- imaging (2)
- immune evasion cluster (2)
- immunogenicity (2)
- impact on pre-activated Achilles tendon (2)
- implicit bias (2)
- in-vitro-synthesis (2)
- individual (2)
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- individual variation (2)
- induced pluripotent stem cells (2)
- inertial measurement unit (2)
- infant development (2)
- infant word learning (2)
- infection (2)
- infiltration (2)
- inflection (2)
- information (2)
- injury (2)
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- insights (2)
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- integrated flood risk management (2)
- integration (2)
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- internal load (2)
- internal structure (2)
- internalization (2)
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- internet addiction (2)
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- interstellar ice (2)
- invasibility (2)
- invasion success (2)
- ionic liquid (2)
- ionogel (2)
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- isometric muscle action (2)
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- jasmonate (2)
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- laboratory (2)
- lactate (2)
- lake Donggi Cona (2)
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- laminitis (2)
- land management (2)
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- landscape generator (2)
- landscape of fear (2)
- landscape transience (2)
- landslides (2)
- large-scale (2)
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- late pleistocene (2)
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- leverage areas (2)
- levoglucosan (2)
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- ligand exchange (2)
- light scattering (2)
- lignocellulosic biomass (2)
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- lipidation (2)
- lipid–lipid interactions (2)
- lipoplexes (2)
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- localisation (2)
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- loci (2)
- logarithmic source condition (2)
- low (2)
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- low-energy electrons (2)
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- maps on surfaces (2)
- margins (2)
- marine terrace (2)
- mass (2)
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- matching dependencies (2)
- mathematics (2)
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- maximum and range (2)
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- mechanical strength (2)
- mechanical tendinous oscillations (2)
- mechanism (2)
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- melatonin (2)
- membrane biophysics (2)
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- membrane stabilization (2)
- mental number line (MNL) (2)
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- mesoscale (2)
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- metagenome (2)
- metagenomic analysis (2)
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- metallic nanolattices (2)
- metaophiolite (2)
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- methodology (2)
- methods: observational (2)
- microbial interactions (2)
- microcomputed tomography (2)
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- microcystin (2)
- micronutrients (2)
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- middle adulthood (2)
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- mobile eye-tracking (2)
- modified Landweber method (2)
- molecular architecture (2)
- molecular bottle brushes (2)
- molecular dynamics simulations (2)
- molecular phylogeny (2)
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- molecularly imprinted polymers (2)
- molybdenum (2)
- molybdopterin synthase (2)
- monomers (2)
- morphological decomposition (2)
- morphological errors (2)
- motion capture (2)
- motor neurons (2)
- movement ecology (2)
- multi-slab (2)
- multidisciplinary pain treatment (2)
- multiplicative noise (2)
- multishell (2)
- multi‐ year flooding cycle (2)
- murchison meteorite (2)
- muscle oxygenation (2)
- muscle power (2)
- muscle strength (2)
- musicality (2)
- n-oxide reductase (2)
- narcissism (2)
- native American ancestry (2)
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- natural-selection (2)
- nature conservation (2)
- necrobiome (2)
- negation (2)
- nested vulnerabilities (2)
- neurodegenerative diseases (2)
- neuroendocrine (2)
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- neuroscience (2)
- neutron (2)
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- nightlights (2)
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- nitrogen limitation (2)
- non-Gaussianity (2)
- non-radiative interface recombination (2)
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- nonlinear operator (2)
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- nucleus (2)
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- ocean acidification (2)
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- oligocene climate (2)
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- organic dye pigments (2)
- organic photovoltaics (2)
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- organic–inorganic hybrid (2)
- origination (2)
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- osmotic-pressure (2)
- osteoporosis (2)
- other-race effect (2)
- overhead athlete (2)
- overhunting (2)
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- overtraining (2)
- overweight (2)
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- parameterization (2)
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- parent (2)
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- part 1 (2)
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- permafrost degradation (2)
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- permeability (2)
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- perpetration (2)
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- phagocytosis (2)
- phase purity (2)
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- photo-isomerization kinetics (2)
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- planetary-waves (2)
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- plant Mediator (2)
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- plant macrofossil data (2)
- plant naturalization (2)
- plant–soil feedback (2)
- plasma (2)
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- playa (2)
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- poly (acrylic acid, sodium salt) (2)
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- polyacrylamide (2)
- polydimethylsiloxane wrinkles (2)
- polymer amphiphile (2)
- polymer degradation (2)
- polymersomes (2)
- polypropylene (2)
- poly‐ ε ‐ caprolactone (2)
- poor literacy (2)
- population-specific risk marker (2)
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- printing (2)
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- protein-protein interaction (2)
- provitamin A (2)
- psychological distress (2)
- psychometric properties (2)
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- rape (2)
- rapid eGFRcrea decline (2)
- rat (2)
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- residents (2)
- resistin (2)
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- retinol-binding protein 4 (2)
- reveals (2)
- reversible shape-memory actuator (2)
- review (2)
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- rhodobacter-capsulatus (2)
- rhythm perception (2)
- risk governance (2)
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- river basins (2)
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- rodents (2)
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- rotation (2)
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- rural populations (2)
- saccade generation (2)
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- saliva (2)
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- salt diffusion (2)
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- san andreas fault (2)
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- sdq (2)
- sea (2)
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- security (2)
- sediment (2)
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- sediment transit time (2)
- seed bank (2)
- selenoprotein P (2)
- self-concept (2)
- self-evaluation (2)
- self-healing (2)
- self-objectification (2)
- self-regulated learning (2)
- self-report measures (2)
- semantics-pragmatics interface (2)
- semi-arid regions (2)
- sensitivity (2)
- sensorimotor exercise training (2)
- sentence comprehension (2)
- seperation (2)
- sequence dependence (2)
- sequence-controlled polymers (2)
- sequence-structure-function relationship (2)
- sequencing error (2)
- serine cycle (2)
- sexual coercion (2)
- sexual self-esteem (2)
- shape‐memory polymer actuators (2)
- shock proteins (2)
- shock waves (2)
- shotgun sequencing (2)
- shrub-encroachment (2)
- signal propagation (2)
- signal transduction (2)
- similarity measures (2)
- simulations (2)
- single chain folding (2)
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- singleslab (2)
- sirna transfection (2)
- size (2)
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- social comparison (2)
- social meaning (2)
- social media advertising (2)
- social referrals (2)
- social science (2)
- societal effects (2)
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- sociometric neglect (2)
- sociometric status (2)
- sodium (2)
- soft X-ray beamline (2)
- soft X-ray spectroscopy (2)
- soft robotics (2)
- soil fatigue (2)
- soil texture (2)
- solar cells (2)
- solar coronal mass ejections (2)
- solar storm (2)
- solubility (2)
- solving of tasks (2)
- somatic comorbidity (2)
- sorghum (2)
- source regions (2)
- source-to-sink (2)
- space (2)
- space-dependent diffusivity (2)
- spatial frequencies (2)
- spatial frequency (SF) (2)
- spatial localization (2)
- spatial-temporal (2)
- speakers (2)
- special sensor microwave imager (2)
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- species composition (2)
- specific surface area (2)
- spectra (2)
- spectral analysis (2)
- speech kinematics (2)
- speech motor control (2)
- speech production (2)
- spiked and crumble gold nanotriangles (2)
- splitting (2)
- spontaneous reaction (2)
- stability and accuracy (2)
- stable water isotope (2)
- standard metrics (2)
- star formation (2)
- starch (2)
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- stars: atmospheres (2)
- stars: evolution (2)
- stars: low-mass (2)
- state (2)
- stationary stochastic process (2)
- status markers (2)
- stellar coronal mass ejections (2)
- stratigraphy (2)
- streamflow (2)
- streamflow trends (2)
- streamflow variability (2)
- stress memory (2)
- structure (2)
- study (2)
- subcellular localization (2)
- subdiffusion (2)
- subject-verb agreement (2)
- submerged sequence (2)
- subsidence (2)
- sugar signalling (2)
- summer monsoon (2)
- support vector machine (2)
- surface plasmon resonance (2)
- surface temperatures (2)
- surface–groundwater interactions (2)
- surveillance (2)
- sustainable development (2)
- sustained casing pressure (2)
- syllables (2)
- symmetric modes (2)
- syntactic priming (2)
- synthesized voice (2)
- systems (2)
- tannic acid (2)
- targeted proteomics (2)
- tasks (2)
- taxonomic (2)
- teacher–student relationship (2)
- teaching (2)
- teaching quality (2)
- team sports (2)
- technology (2)
- tectonic inversion (2)
- temperature dependence (2)
- temperature-related mortality (2)
- temporal frequency (2)
- temporary wetland (2)
- testis (2)
- text-to-speech (2)
- therapeutics (2)
- thermal-stress (2)
- thermokarst (2)
- thermokarst lakes (2)
- thickness-displacement relationships (2)
- thin films (2)
- tibetan plateau (2)
- tide gauge observations (2)
- time-scale (2)
- time-series mapping (2)
- timing (2)
- top-down parsing (2)
- total electron-content (2)
- trajectory data (2)
- transcript (2)
- transcription (2)
- transcriptional memory (2)
- transfer dynamics (2)
- transient expression (2)
- transit-time (2)
- transition (2)
- transmission (2)
- transport network companies (2)
- transport processes (2)
- travel time distributions (2)
- trehalose 6-phosphate (2)
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Challenges, triggers and initiators of climate policies and implications for policy formulation
(2020)
The combined effect of ultraviolet (UV) light soaking and self-assembled monolayer deposition on the work function (WF) of thin ZnO layers and on the efficiency of hole injection into the prototypical conjugated polymer poly(3-hexylthiophen-2,5-diyl) (P3HT) is systematically investigated. It is shown that the WF and injection efficiency depend strongly on the history of UV light exposure. Proper treatment of the ZnO layer enables ohmic hole injection into P3HT, demonstrating ZnO as a potential anode material for organic optoelectronic devices. The results also suggest that valid conclusions on the energy-level alignment at the ZnO/organic interfaces may only be drawn if the illumination history is precisely known and controlled. This is inherently problematic when comparing electronic data from ultraviolet photoelectron spectroscopy (UPS) measurements carried out under different or ill-defined illumination conditions.
Background:
Anti-TNFα monoclonal antibodies (mAbs) are a well-established treatment for patients with Crohn’s disease (CD). However, subtherapeutic concentrations of mAbs have been related to a loss of response during the first year of therapy1. Therefore, an appropriate dosing strategy is crucial to prevent the underexposure of mAbs for those patients. The aim of our study was to assess the impact of different dosing strategies (fixed dose or body size descriptor adapted) on drug exposure and the target concentration attainment for two different anti-TNFα mAbs: infliximab (IFX, body weight (BW)-based dosing) and certolizumab pegol (CZP, fixed dosing). For this purpose, a comprehensive pharmacokinetic (PK) simulation study was performed.
Methods:
A virtual population of 1000 clinically representative CD patients was generated based on the distribution of CD patient characteristics from an in-house clinical database (n = 116). Seven dosing regimens were investigated: fixed dose and per BW, lean BW (LBW), body surface area, height, body mass index and fat-free mass. The individual body size-adjusted doses were calculated from patient generated body size descriptor values. Then, using published PK models for IFX and CZP in CD patients2,3, for each patient, 1000 concentration–time profiles were simulated to consider the typical profile of a specific patient as well as the range of possible individual profiles due to unexplained PK variability across patients. For each dosing strategy, the variability in maximum and minimum mAb concentrations (Cmax and Cmin, respectively), area under the concentration-time curve (AUC) and the per cent of patients reaching target concentration were assessed during maintenance therapy.
Results:
For IFX and CZP, Cmin showed the highest variability between patients (CV ≈110% and CV ≈80%, respectively) with a similar extent across all dosing strategies. For IFX, the per cent of patients reaching the target (Cmin = 5 µg/ml) was similar across all dosing strategies (~15%). For CZP, the per cent of patients reaching the target average concentration of 17 µg/ml ranged substantially (52–71%), being the highest for LBW-adjusted dosing.
Conclusion:
By using a PK simulation approach, different dosing regimen of IFX and CZP revealed the highest variability for Cmin, the most commonly used PK parameter guiding treatment decisions, independent upon dosing regimen. Our results demonstrate similar target attainment with fixed dosing of IFX compared with currently recommended BW-based dosing. For CZP, the current fixed dosing strategy leads to comparable percentage of patients reaching target as the best performing body size-adjusted dosing (66% vs. 71%, respectively).
The termprocess modelis widely used, but rarely agreed upon. This paper proposes a framework for characterizing and building cognitive process models. Process models model not only inputs and outputs but also model the ongoing information transformations at a given level of abstraction. We argue that the following dimensions characterize process models: They have a scope that includes different levels of abstraction. They specify a hypothesized mental information transformation. They make predictions not only for the behavior of interest but also for processes. The models' predictions for the processes can be derived from the input, without reverse inference from the output data. Moreover, the presumed information transformation steps are not contradicting current knowledge of human cognitive capacities. Lastly, process models require a conceptual scope specifying levels of abstraction for the information entering the mind, the proposed mental events, and the behavior of interest. This framework can be used for refining models before testing them or after testing them empirically, and it does not rely on specific modeling paradigms. It can be a guideline for developing cognitive process models. Moreover, the framework can advance currently unresolved debates about which models belong to the category of process models.
In the comment on "Varves of the Dead Sea sedimentary record." Quaternary Science Reviews 215 (Ben Dor et al., 2019): 173-184. by R. Bookman, two recently published papers are suggested to prove that the interpretation of the laminated sedimentary sequence of the Dead Sea, deposited mostly during MIS2 and Holocene pluvials, as annual deposits (i.e., varves) is wrong. In the following response, we delineate several lines of evidence which coalesce to demonstrate that based on the vast majority of evidence, including some of the evidence provided in the comment itself, the interpretation of these sediments as varves is the more likely scientific conclusion. We further discuss the evidence brought up in the comment and its irrelevance and lack of robustness for addressing the question under discussion.
Aldehyde oxidases (AOXs) are a small group of enzymes belonging to the larger family of molybdo-flavoenzymes, along with the well-characterized xanthine oxidoreductase. The two major types of reactions that are catalyzed by AOXs are the hydroxylation of heterocycles and the oxidation of aldehydes to their corresponding carboxylic acids. Different animal species have different complements of AOX genes. The two extremes are represented in humans and rodents; whereas the human genome contains a single active gene (AOX1), those of rodents, such as mice, are endowed with four genes (Aox1-4), clustering on the same chromosome, each encoding a functionally distinct AOX enzyme. It still remains enigmatic why some species have numerous AOX enzymes, whereas others harbor only one functional enzyme. At present, little is known about the physiological relevance of AOX enzymes in humans and their additional forms in other mammals. These enzymes are expressed in the liver and play an important role in the metabolisms of drugs and other xenobiotics. In this review, we discuss the expression, tissue-specific roles, and substrate specificities of the different mammalian AOX enzymes and highlight insights into their physiological roles.
Broad and unspecific use of antibiotics accelerates spread of resistances. Sensitive and robust pathogen detection is thus important for a more targeted application. Bacteriophages contain a large repertoire of pathogen-binding proteins. These tailspike proteins (TSP) often bind surface glycans and represent a promising design platform for specific pathogen sensors. We analysed bacteriophage Sf6 TSP that recognizes the O-polysaccharide of dysentery-causing Shigella flexneri to develop variants with increased sensitivity for sensor applications. Ligand polyrhamnose backbone conformations were obtained from 2D H-1,H-1-trNOESY NMR utilizing methine-methine and methine-methyl correlations. They agreed well with conformations obtained from molecular dynamics (MD), validating the method for further predictions. In a set of mutants, MD predicted ligand flexibilities that were in good correlation with binding strength as confirmed on immobilized S. flexneri O-polysaccharide (PS) with surface plasmon resonance. In silico approaches combined with rapid screening on PS surfaces hence provide valuable strategies for TSP-based pathogen sensor design.
Do all roads lead to Rome?
(2020)
Content website providers have two main goals: They seek to attract consumers and to keep them on their websites as long as possible. To reach potential consumers, they can utilize several online channels, such as paid search results or advertisements on social media, all of which usually require a substantial marketing budget. However, with rising user numbers of online communication tools, website providers increasingly integrate social sharing buttons on their websites to encourage existing consumers to facilitate referrals to their social networks. While little is known about this social form of guiding consumers to a content website, the study proposes that the way in which consumers reach a website is related to their stickiness to the website and their propensity to refer content to others. By using a unique clickstream data set of a video-on-demand website, the study compares consumers referred by their social network to those consumers arriving at the website via organic search or social media advertisements in terms of stickiness to the website (e.g., visit length, number of page views, video starts) and referral likelihood. The results show that consumers referred through social referrals spend more time on the website, view more pages, and start more videos than consumers who respond to social media advertisements, but less than those coming through organic search. Concerning referral propensity, the results indicate that consumers attracted to a website through social referrals are more likely to refer content to others than those who came through organic search or social media advertisements. The study offers direct insights to managers and recommends an increase in their efforts to promote social referrals on their websites.
Do all roads lead to Rome?
(2020)
Content website providers have two main goals: They seek to attract consumers and to keep them on their websites as long as possible. To reach potential consumers, they can utilize several online channels, such as paid search results or advertisements on social media, all of which usually require a substantial marketing budget. However, with rising user numbers of online communication tools, website providers increasingly integrate social sharing buttons on their websites to encourage existing consumers to facilitate referrals to their social networks. While little is known about this social form of guiding consumers to a content website, the study proposes that the way in which consumers reach a website is related to their stickiness to the website and their propensity to refer content to others. By using a unique clickstream data set of a video-on-demand website, the study compares consumers referred by their social network to those consumers arriving at the website via organic search or social media advertisements in terms of stickiness to the website (e.g., visit length, number of page views, video starts) and referral likelihood. The results show that consumers referred through social referrals spend more time on the website, view more pages, and start more videos than consumers who respond to social media advertisements, but less than those coming through organic search. Concerning referral propensity, the results indicate that consumers attracted to a website through social referrals are more likely to refer content to others than those who came through organic search or social media advertisements. The study offers direct insights to managers and recommends an increase in their efforts to promote social referrals on their websites.
This article explores the structural diversity of intraministerial organization over time. Based on organization theory, it proposes a generic typology for intraministerial units applicable to any hierarchically structured government organization. We empirically investigate the critical case of the German federal bureaucracy. By classifying its subunits, we analyze the longitudinal development of structural differentiation and its correspondence to denominational variety. The data stem from a novel international dataset, covering all ministries between 1980 and 2015. We find that intraministerial structure differentiates over time, across and within ministries. A stable core of traditional Weberian structure is complemented by structurally innovative intraministerial units. We conclude that the German federal bureaucracy is more diverse than suggested in previous literature. Our findings indicate that less Weberian bureaucracies are at least as structurally diverse and that more reform-driven bureaucracies will have experienced at least as many changes in structural diversity.
Birds of a feather?
(2020)
The International Monetary Fund and the World Bank ascribe to impartiality in their mandates. At the same time, scholarship indicates that their decisions are disproportionately influenced by powerful member states. Impartiality is seen as crucial in determining International Organizations' (IOs) effectiveness and legitimacy in the literature. However, we know little about whether key interlocutors in national governments perceive the International Financial Institutions as biased actors who do the bidding for powerful member states or as impartial executors of policy. In order to better understand these perceptions, we surveyed high-level civil servants who are chiefly responsible for four policy areas from more than 100 countries. We found substantial variations in impartiality perceptions. What explains these variations? By developing an argument of selective awareness, we extend rationalist and ideational perspectives on IO impartiality to explain domestic perceptions. Using novel survey data, we test whether staffing underrepresentation, voting underrepresentation, alignment to the major shareholders and overlapping economic policy paradigms are associated with impartiality perceptions. We find substantial evidence that shared economic policy paradigms influence impartiality perceptions. The findings imply that by diversifying their ideational culture, IOs can increase the likelihood that domestic stakeholders view them as impartial.
The COVID-19 virus has hit Germany as unexpectedly as other European countries. For a few weeks, Germans thought that COVID-19 was an issue for Asian states and not for their country. Although Germany continues to be affected by the coronavirus, the situation is nowhere as dire as it was in Britain, Italy or Spain. The race to lift restrictions in Germany began in May, and by early June, the country may be back to normal. Germany, with its enormous financial resources and a well-equipped medical sector, appears to be better placed than other economies to weather the storm.
Germany as a leading power
(2020)
Scholars have long recognised the importance of contexts of reception in shaping the integration of immigrants and refugees in a host society. Studies of refugees, in particular, have examined groups where the different dimensions of reception (government, labour market, and ethnic community) have been largely positive. How important is this merging of positive contexts across dimensions of reception? We address this through a comparative study of Vietnamese refugees to West Germany beginning in 1979 and contract workers to East Germany beginning in 1980. These two migration streams converged when Germany reunified in 1990. Drawing on mixed qualitative methods, this paper offers a strategic case for understanding factors that shape the resettlement experiences of Vietnamese refugees and immigrants in Germany. By comparing two migration streams from the same country of origin, but with different backgrounds and contexts of reception, we suggest that ethnic networks may, in time, offset the disadvantages of a negative government reception.
Value research has a long and extensive history of theoretical definitions and empirical investigations using large scale quantitative surveys. However, the way the general population understands, defines, and relates to the concept of values, and how these views vary across individuals is seldom addressed. The present study examined subjective interpretations of the term through focus group interviews, and reports on the development of a Value Conceptualisation Scale (VCS) that distinguishes six dimensions of different views on values: normativity, relevance, validity, stability, consistency, and awareness. Focus group interviews (n = 38) as well as several surveys (n = 100, n = 1519, n = 903, n = 94) were used to develop, refine, and test the scale in terms of response variety, temporal stability, as well as convergent and discriminant validity. These systematic results show that views on values do indeed vary significantly between participants. Correlations with dogmatism, preference for consistency, and metacognition were found for corresponding dimensions. The VCS provides an original measure, which enables future research to explore this variation on the conceptualisation of values.
Better land stewardship is needed to achieve the Paris Agreement's temperature goal, particularly in the tropics, where greenhouse gas emissions from the destruction of ecosystems are largest, and where the potential for additional land carbon storage is greatest. As countries enhance their nationally determined contributions (NDCs) to the Paris Agreement, confusion persists about the potential contribution of better land stewardship to meeting the Agreement's goal to hold global warming below 2 degrees C. We assess cost-effective tropical country-level potential of natural climate solutions (NCS)-protection, improved management and restoration of ecosystems-to deliver climate mitigation linked with sustainable development goals (SDGs). We identify groups of countries with distinctive NCS portfolios, and we explore factors (governance, financial capacity) influencing the feasibility of unlocking national NCS potential. Cost-effective tropical NCS offers globally significant climate mitigation in the coming decades (6.56 Pg CO(2)e yr(-1) at less than 100 US$ per Mg CO(2)e). In half of the tropical countries, cost-effective NCS could mitigate over half of national emissions. In more than a quarter of tropical countries, cost-effective NCS potential is greater than national emissions. We identify countries where, with international financing and political will, NCS can cost-effectively deliver the majority of enhanced NDCs while transforming national economies and contributing to SDGs. This article is part of the theme issue 'Climate change and ecosystems: threats, opportunities and solutions'.
Better land stewardship is needed to achieve the Paris Agreement's temperature goal, particularly in the tropics, where greenhouse gas emissions from the destruction of ecosystems are largest, and where the potential for additional land carbon storage is greatest. As countries enhance their nationally determined contributions (NDCs) to the Paris Agreement, confusion persists about the potential contribution of better land stewardship to meeting the Agreement's goal to hold global warming below 2 degrees C. We assess cost-effective tropical country-level potential of natural climate solutions (NCS)-protection, improved management and restoration of ecosystems-to deliver climate mitigation linked with sustainable development goals (SDGs). We identify groups of countries with distinctive NCS portfolios, and we explore factors (governance, financial capacity) influencing the feasibility of unlocking national NCS potential. Cost-effective tropical NCS offers globally significant climate mitigation in the coming decades (6.56 Pg CO(2)e yr(-1) at less than 100 US$ per Mg CO(2)e). In half of the tropical countries, cost-effective NCS could mitigate over half of national emissions. In more than a quarter of tropical countries, cost-effective NCS potential is greater than national emissions. We identify countries where, with international financing and political will, NCS can cost-effectively deliver the majority of enhanced NDCs while transforming national economies and contributing to SDGs. This article is part of the theme issue 'Climate change and ecosystems: threats, opportunities and solutions'.
This article merges theoretical literature on non-controlling minority shareholdings (NCMS) in a coherent model to study the effects of NCMS on competition and collusion. The model encompasses both the case of a common owner holding shares of rival firms as well as the case of cross ownership among rivals. We find that by softening competition, NCMS weaken the sustainability of collusion under a greater variety of situations than was indicated by earlier literature. Such effects exist, in particular, in the presence of an effective competition authority.
In nature, plants are constantly exposed to many transient, but recurring, stresses. Thus, to complete their life cycles, plants require a dynamic balance between capacities to recover following cessation of stress and maintenance of stress memory. Recently, we uncovered a new functional role for macroautophagy/autophagy in regulating recovery from heat stress (HS) and resetting cellular memory of HS inArabidopsis thaliana. Here, we demonstrated that NBR1 (next to BRCA1 gene 1) plays a crucial role as a receptor for selective autophagy during recovery from HS. Immunoblot analysis and confocal microscopy revealed that levels of the NBR1 protein, NBR1-labeled puncta, and NBR1 activity are all higher during the HS recovery phase than before. Co-immunoprecipitation analysis of proteins interacting with NBR1 and comparative proteomic analysis of annbr1-null mutant and wild-type plants identified 58 proteins as potential novel targets of NBR1. Cellular, biochemical and functional genetic studies confirmed that NBR1 interacts with HSP90.1 (heat shock protein 90.1) and ROF1 (rotamase FKBP 1), a member of the FKBP family, and mediates their degradation by autophagy, which represses the response to HS by attenuating the expression ofHSPgenes regulated by the HSFA2 transcription factor. Accordingly, loss-of-function mutation ofNBR1resulted in a stronger HS memory phenotype. Together, our results provide new insights into the mechanistic principles by which autophagy regulates plant response to recurrent HS.
Although many studies have shown that victims of child abuse have an increased vulnerability to revictimization in intimate relationships, the underlying mechanisms are not yet sufficiently well understood. Therefore, this study aimed at examining this relationship for both sexual and physical forms of violence as well as investigating the potential mediating role of attitudes toward sexual and physical intimate partner violence (IPV). Also, the potential moderating role of gender was explored. Sexual and physical child abuse and IPV victimization in adulthood as well as attitudes toward the respective form of IPV were assessed among 716 participants (448 female) in an online survey. The path analyses showed that child sexual abuse was positively linked to sexual IPV victimization among both women and men, whereas child physical abuse was positively associated with physical IPV victimization among women only. Furthermore, the relationship between both forms of child abuse and IPV victimization was mediated through more supportive attitudes toward the respective forms of IPV, but only among men. This study provides novel insights regarding the links between sexual and physical child abuse and revictimization in adulthood, suggesting that supporting attitudes toward IPV may be seen as vulnerability factor for revictimization. The moderating role of gender is especially discussed.
As research on sexual aggression has been growing, methodological issues in assessing prevalence rates have received increased attention. Building on work by Abbey and colleagues about effects of question format, participants in this study (1,253; 621 female; 632 male) were randomly assigned to one of two versions of the Sexual Aggression and Victimization Scale (SAV-S). In Version 1, the coercive tactic (use/threat of physical force, exploitation of the inability to resist, verbal pressure) was presented first, and sexual acts (sexual touch, attempted and completed sexual intercourse, other sexual acts) were presented as subsequent questions. In Version 2, sexual acts were presented first, and coercive tactics as subsequent questions. No version effects emerged for overall perpetration rates reported by men and women. The overall victimization rate across all items was significantly higher in the tactic-first than in the sexual-act-first conditions for women, but not for men. Classifying participants by their most severe experience of sexual victimization showed that fewer women were in the nonvictim category and more men were in the nonconsensual sexual contact category when the coercive tactic was presented first. Sexual experience background did not moderate the findings. The implications for the measurement of self-reported sexual aggression victimization and perpetration are discussed.
A growing body of research has demonstrated negative effects of sexualization in the media on adolescents' body image, but longitudinal studies and research including interactive and social media are scarce. The current study explored the longitudinal associations of adolescents' use of sexualized video games (SVG) and sexualized Instagram images (SII) with body image concerns. Specifically, our study examined relations between adolescents' SVG and SII use and appearance comparisons, thin- and muscular-ideal internalization, valuing appearance over competence, and body surveillance. A sample of 660 German adolescents (327 female, 333 male;M-age = 15.09 years) participated in two waves with an interval of 6 months. A structural equation model showed that SVG and SII use at Time 1 predicted body surveillance indirectly via valuing appearance over competence at Time 2. Furthermore, SVG and SII use indirectly predicted both thin- and muscular-ideal internalization through appearance comparisons at Time 1. In turn, thin-ideal internalization at Time 1 predicted body surveillance indirectly via valuing appearance over competence at Time 2. The results indicate that sexualization in video games and on Instagram can play an important role in increasing body image concerns among adolescents. We discuss the findings with respect to objectification theory and the predictive value of including appearance comparisons in models explaining the relation between sexualized media and self-objectification.
Magnitude estimation has been studied since the beginnings of scientific psychology and constitutes a fundamental aspect of human behavior. Yet, it has apparently never been noticed that estimates depend on the spatial arrangement used. We tested 167 adults in three experiments to show that the spatial layout of stimuli and responses systematically distorts number estimation, length production, and weight reproduction performance. The direction of distortion depends on the observer's counting habits, but does not seem to reflect the use of spatially associated number concepts. Our results imply that all quantitative estimates are contaminated by a "spell of space" whenever stimuli or responses are spatially distributed.
Alcohol use disorder (AUD) is the most common substance use disorder worldwide. Although dopamine-related findings were often observed in AUD, associated neurobiological mechanisms are still poorly understood. Therefore, in the present study, we investigate D2/3 receptor availability in healthy participants, participants at high risk (HR) to develop addiction (not diagnosed with AUD), and AUD patients in a detoxified stage, applying F-18-fallypride positron emission tomography (F-18-PET). Specifically, D2/3 receptor availability was investigated in (1) 19 low-risk (LR) controls, (2) 19 HR participants, and (3) 20 AUD patients after alcohol detoxification. Quality and severity of addiction were assessed with clinical questionnaires and (neuro)psychological tests. PET data were corrected for age of participants and smoking status. In the dorsal striatum, we observed significant reductions of D2/3 receptor availability in AUD patients compared with LR participants. Further, receptor availability in HR participants was observed to be intermediate between LR and AUD groups (linearly decreasing). Still, in direct comparison, no group difference was observed between LR and HR groups or between HR and AUD groups. Further, the score of the Alcohol Dependence Scale (ADS) was inversely correlated with D2/3 receptor availability in the combined sample. Thus, in line with a dimensional approach, striatal D2/3 receptor availability showed a linear decrease from LR participants to HR participants to AUD patients, which was paralleled by clinical measures. Our study shows that a core neurobiological feature in AUD seems to be detectable in an early, subclinical state, allowing more individualized alcohol prevention programs in the future.
Both climate change and land use regimes affect the viability of populations, but they are often studied separately. Moreover, population viability analyses (PVAs) often ignore the effects of large environmental gradients and use temporal resolutions that are too coarse to take into account that different stages of a population's life cycle may be affected differently by climate change. Here, we present the High-resolution Large Environmental Gradient (HiLEG) model and apply it in a PVA with daily resolution based on daily climate projections for Northwest Germany. We used the large marsh grasshopper (LMG) as the target species and investigated (1) the effects of climate change on the viability and spatial distribution of the species, (2) the influence of the timing of grassland mowing on the species and (3) the interaction between the effects of climate change and grassland mowing. The stageand cohort-based model was run for the spatially differentiated environmental conditions temperature and soil moisture across the whole study region. We implemented three climate change scenarios and analyzed the population dynamics for four consecutive 20-year periods. Climate change alone would lead to an expansion of the regions suitable for the LMG, as warming accelerates development and due to reduced drought stress. However, in combination with land use, the timing of mowing was crucial, as this disturbance causes a high mortality rate in the aboveground life stages. Assuming the same date of mowing throughout the region, the impact on viability varied greatly between regions due to the different climate conditions. The regional negative effects of the mowing date can be divided into five phases: (1) In early spring, the populations were largely unaffected in all the regions; (2) between late spring and early summer, they were severely affected only in warm regions; (3) in summer, all the populations were severely affected so that they could hardly survive; (4) between late summer and early autumn, they were severely affected in cold regions; and (5) in autumn, the populations were equally affected across all regions. The duration and start of each phase differed slightly depending on the climate change scenario and simulation period, but overall, they showed the same pattern. Our model can be used to identify regions of concern and devise management recommendations. The model can be adapted to the life cycle of different target species, climate projections and disturbance regimes. We show with our adaption of the HiLEG model that high-resolution PVAs and applications on large environmental gradients can be reconciled to develop conservation strategies capable of dealing with multiple stressors.
This systematic review investigated how successful children/adolescents with poor literacy skills learn a foreign language compared with their peers with typical literacy skills. Moreover, we explored whether specific characteristics related to participants, foreign language instruction, and assessment moderated scores on foreign language tests in this population. Overall, 16 studies with a total of 968 participants (poor reader/spellers:n = 404; control participants:n = 564) met eligibility criteria. Only studies focusing on English as a foreign language were available. Available data allowed for meta-analyses on 10 different measures of foreign language attainment. In addition to standard mean differences (SMDs), we computed natural logarithms of the ratio of coefficients of variation (CVRs) to capture individual variability between participant groups. Significant between-study heterogeneity, which could not be explained by moderator analyses, limited the interpretation of results. Although children/adolescents with poor literacy skills on average showed lower scores on foreign language phonological awareness, letter knowledge, and reading comprehension measures, their performance varied significantly more than that of control participants. Thus, it remains unclear to what extent group differences between the foreign language scores of children/adolescents with poor and typical literacy skills are representative of individual poor readers/spellers. Taken together, our results indicate that foreign language skills in children/adolescents with poor literacy skills are highly variable. We discuss the limitations of past research that can guide future steps toward a better understanding of individual differences in foreign language attainment of children/adolescents with poor literacy skills.
Alcohol intoxication is known to affect many aspects of human behavior and cognition; one of such affected systems is articulation during speech production. Although much research has revealed that alcohol negatively impacts pronunciation in a first language (L1), there is only initial evidence suggesting a potential beneficial effect of inebriation on articulation in a non-native language (L2). The aim of this study was thus to compare the effect of alcohol consumption on pronunciation in an L1 and an L2. Participants who had ingested different amounts of alcohol provided speech samples in their L1 (Dutch) and L2 (English), and native speakers of each language subsequently rated the pronunciation of these samples on their intelligibility (for the L1) and accent nativelikeness (for the L2). These data were analyzed with generalized additive mixed modeling. Participants' blood alcohol concentration indeed negatively affected pronunciation in L1, but it produced no significant effect on the L2 accent ratings. The expected negative impact of alcohol on L1 articulation can be explained by reduction in fine motor control. We present two hypotheses to account for the absence of any effects of intoxication on L2 pronunciation: (1) there may be a reduction in L1 interference on L2 speech due to decreased motor control or (2) alcohol may produce a differential effect on each of the two linguistic subsystems.
Alcohol intoxication is known to affect many aspects of human behavior and cognition; one of such affected systems is articulation during speech production. Although much research has revealed that alcohol negatively impacts pronunciation in a first language (L1), there is only initial evidence suggesting a potential beneficial effect of inebriation on articulation in a non-native language (L2). The aim of this study was thus to compare the effect of alcohol consumption on pronunciation in an L1 and an L2. Participants who had ingested different amounts of alcohol provided speech samples in their L1 (Dutch) and L2 (English), and native speakers of each language subsequently rated the pronunciation of these samples on their intelligibility (for the L1) and accent nativelikeness (for the L2). These data were analyzed with generalized additive mixed modeling. Participants' blood alcohol concentration indeed negatively affected pronunciation in L1, but it produced no significant effect on the L2 accent ratings. The expected negative impact of alcohol on L1 articulation can be explained by reduction in fine motor control. We present two hypotheses to account for the absence of any effects of intoxication on L2 pronunciation: (1) there may be a reduction in L1 interference on L2 speech due to decreased motor control or (2) alcohol may produce a differential effect on each of the two linguistic subsystems.
Objective:
Depression and coronary heart disease (CHD) are highly comorbid conditions. Brain-derived neurotrophic factor (BDNF) plays an important role in cardiovascular processes. Depressed patients typically show decreased BDNF concentrations. We analysed the relationship between BDNF and depression in a sample of patients with CHD and additionally distinguished between cognitive-affective and somatic depression symptoms. We also investigated whether BDNF was associated with somatic comorbidity burden, acute coronary syndrome (ACS) or congestive heart failure (CHF).
Methods:
The following variables were assessed for 225 hospitalised patients with CHD: BDNF concentrations, depression [Patient Health Questionnaire-9 (PHQ-9)], somatic comorbidity (Charlson Comorbidity Index), CHF, ACS, platelet count, smoking status and antidepressant treatment.
Results:
Regression models revealed that BDNF was not associated with severity of depression. Although depressed patients (PHQ-9 score >7) had significantly lower BDNF concentrations compared to non-depressed patients (p = 0.04), this was not statistically significant after controlling for confounders (p = 0.15). Cognitive-affective symptoms and somatic comorbidity burden each closely missed a statistically significant association with BDNF concentrations (p = 0.08, p = 0.06, respectively). BDNF was reduced in patients with CHF (p = 0.02). There was no covariate-adjusted, significant association between BDNF and ACS.
Conclusion:
Serum BDNF concentrations are associated with cardiovascular dysfunction. Somatic comorbidities should be considered when investigating the relationship between depression and BDNF.
Objective:
Depression and coronary heart disease (CHD) are highly comorbid conditions. Brain-derived neurotrophic factor (BDNF) plays an important role in cardiovascular processes. Depressed patients typically show decreased BDNF concentrations. We analysed the relationship between BDNF and depression in a sample of patients with CHD and additionally distinguished between cognitive-affective and somatic depression symptoms. We also investigated whether BDNF was associated with somatic comorbidity burden, acute coronary syndrome (ACS) or congestive heart failure (CHF).
Methods:
The following variables were assessed for 225 hospitalised patients with CHD: BDNF concentrations, depression [Patient Health Questionnaire-9 (PHQ-9)], somatic comorbidity (Charlson Comorbidity Index), CHF, ACS, platelet count, smoking status and antidepressant treatment.
Results:
Regression models revealed that BDNF was not associated with severity of depression. Although depressed patients (PHQ-9 score >7) had significantly lower BDNF concentrations compared to non-depressed patients (p = 0.04), this was not statistically significant after controlling for confounders (p = 0.15). Cognitive-affective symptoms and somatic comorbidity burden each closely missed a statistically significant association with BDNF concentrations (p = 0.08, p = 0.06, respectively). BDNF was reduced in patients with CHF (p = 0.02). There was no covariate-adjusted, significant association between BDNF and ACS.
Conclusion:
Serum BDNF concentrations are associated with cardiovascular dysfunction. Somatic comorbidities should be considered when investigating the relationship between depression and BDNF.
Pavlovian-to-instrumental transfer (PIT) tasks examine the influence of Pavlovian stimuli on ongoing instrumental behaviour. Previous studies reported associations between a strong PIT effect, high-risk drinking and alcohol use disorder. This study investigated whether susceptibility to interference between Pavlovian and instrumental control is linked to risky alcohol use in a community sample of 18-year-old male adults. Participants (N = 191) were instructed to 'collect good shells' and 'leave bad shells' during the presentation of appetitive (monetary reward), aversive (monetary loss) or neutral Pavlovian stimuli. We compared instrumental error rates (ER) and functional magnetic resonance imaging (fMRI) brain responses between the congruent and incongruent conditions, as well as among high-risk and low-risk drinking groups. On average, individuals showed a substantial PIT effect, that is, increased ER when Pavlovian cues and instrumental stimuli were in conflict compared with congruent trials. Neural PIT correlates were found in the ventral striatum and the dorsomedial and lateral prefrontal cortices (lPFC). Importantly, high-risk drinking was associated with a stronger behavioural PIT effect, a decreased lPFC response and an increased neural response in the ventral striatum on the trend level. Moreover, high-risk drinkers showed weaker connectivity from the ventral striatum to the lPFC during incongruent trials. Our study links interference during PIT to drinking behaviour in healthy, young adults. High-risk drinkers showed higher susceptibility to Pavlovian cues, especially when they conflicted with instrumental behaviour, indicating lower interference control abilities. Increased activity in the ventral striatum (bottom-up), decreased lPFC response (top-down), and their altered interplay may contribute to poor interference control in the high-risk drinkers.
Gender stereotypes influence subjective beliefs about the world, and this is reflected in our use of language. But do gender biases in language transparently reflect subjective beliefs? Or is the process of translating thought to language itself biased? During the 2016 United States (N = 24,863) and 2017 United Kingdom (N = 2,609) electoral campaigns, we compared participants' beliefs about the gender of the next head of government with their use and interpretation of pronouns referring to the next head of government. In the United States, even when the female candidate was expected to win, she pronouns were rarely produced and induced substantial comprehension disruption. In the United Kingdom, where the incumbent female candidate was heavily favored, she pronouns were preferred in production but yielded no comprehension advantage. These and other findings suggest that the language system itself is a source of implicit biases above and beyond previously known biases, such as those measured by the Implicit Association Test.
Gender stereotypes influence subjective beliefs about the world, and this is reflected in our use of language. But do gender biases in language transparently reflect subjective beliefs? Or is the process of translating thought to language itself biased? During the 2016 United States (N = 24,863) and 2017 United Kingdom (N = 2,609) electoral campaigns, we compared participants' beliefs about the gender of the next head of government with their use and interpretation of pronouns referring to the next head of government. In the United States, even when the female candidate was expected to win, she pronouns were rarely produced and induced substantial comprehension disruption. In the United Kingdom, where the incumbent female candidate was heavily favored, she pronouns were preferred in production but yielded no comprehension advantage. These and other findings suggest that the language system itself is a source of implicit biases above and beyond previously known biases, such as those measured by the Implicit Association Test.
Aim
Although research and clinical definitions of psychotherapeutic competence have been proposed, less is known about the layperson perspective. The aim was to explore the views of individuals with different levels of psychotherapy experience regarding what-in their views-constitutes a competent therapist.
Method
In an online survey, 375 persons (64% female, mean age 33.24 years) with no experience, with professional experience, or with personal pre-experience with psychotherapy participated. To provide low-threshold questions, we first presented two qualitative items (i.e. "In your opinion, what makes a good/competent psychotherapist?"; "How do you recognize that a psychotherapist is not competent?") and analysed them using inductive content analysis techniques (Mayring, 2014). Then, we gave participants a 16-item questionnaire including items from previous surveys and from the literature and analysed them descriptively.
Results
Work-relatedprinciples, professionalism, personalitycharacteristics, caringcommunication, empathy and understandingwere important categories of competence. Concerning the quantitative questions, most participants agreed with items indicating that a therapist should be open, listen well, show empathy and behave responsibly.
Conclusion
Investigating layperson perspectives suggested that effective and professional interpersonal behaviour of therapists plays a central role in the public's perception of psychotherapy.
Schema modes (ormodes) are a key concept in the theory underlying schema therapy. Modes have rarely been related to established models of personality traits. The present study thus investigates the associations between trait emotional intelligence (TEI) and 14 modes, and tests a global TEI-mode factors-general psychological distress mediation model. The study draws on self-report data from 173 inpatients from a German clinic for psychosomatic medicine. Global TEI correlated positively with both healthy modes (happy child and healthy adult) and negatively with 10 maladaptive modes. When modes were regressed on the four TEI factors, six (emotionality), five (well-being), four (sociability), and four (self-control) significant partial effects on 10 modes emerged. In the parallel mediation model, the mode factors internalization and compulsivity fully mediated the global TEI-general psychological distress link. Implications of the results for the integration of modes with traits in general and with TEI in particular as well as implications of low TEI as a transdiagnostic feature of personality malfunctioning are discussed.
Sexual aggression is a problem among college students worldwide, and a growing body of research has identified variables associated with an increased risk of victimization and perpetration. Among these, sexuality-related cognitions, such as sexual scripts, sexual self-esteem, perceived realism of pornography, and acceptance of sexual coercion, play a major role. The current experimental study aimed to show that these cognitive risk factors of sexual aggression victimization and perpetration are amenable to change, which is a critical condition for evidence-based intervention efforts. College students in Germany (N = 324) were randomly assigned to one of three groups: a treatment group designed to change participants' sexual scripts for consensual sex with regard to the role of alcohol consumption, casual sex, and ambiguous communication of sexual intentions as risk factors for sexual aggression (EG1), a treatment group designed to promote sexual self-esteem, challenge the perceived realism of pornography, and reduce the acceptance of sexual coercion (EG2), and a non-treatment control group (CG). Baseline (T1), post-experimental (T2), and follow-up (T3) measures were taken across an eight-week period. Sexual scripts contained fewer risk factors for sexual aggression in EG1 than in EG2 and CG at T3. Sexual self-esteem was enhanced in EG2 at T2 relative to the other two groups. Acceptance of sexual coercion was lower in EG2 than in EG1 and CG at T2 and T3. No effect was found for perceived realism of pornography. The findings are discussed in terms of targeting cognitive risk factors as a basis for intervention programs.
Making sense of the world
(2020)
For human infants, the first years after birth are a period of intense exploration-getting to understand their own competencies in interaction with a complex physical and social environment. In contemporary neuroscience, the predictive-processing framework has been proposed as a general working principle of the human brain, the optimization of predictions about the consequences of one's own actions, and sensory inputs from the environment. However, the predictive-processing framework has rarely been applied to infancy research. We argue that a predictive-processing framework may provide a unifying perspective on several phenomena of infant development and learning that may seem unrelated at first sight. These phenomena include statistical learning principles, infants' motor and proprioceptive learning, and infants' basic understanding of their physical and social environment. We discuss how a predictive-processing perspective can advance the understanding of infants' early learning processes in theory, research, and application.
Making sense of the world
(2020)
For human infants, the first years after birth are a period of intense exploration-getting to understand their own competencies in interaction with a complex physical and social environment. In contemporary neuroscience, the predictive-processing framework has been proposed as a general working principle of the human brain, the optimization of predictions about the consequences of one's own actions, and sensory inputs from the environment. However, the predictive-processing framework has rarely been applied to infancy research. We argue that a predictive-processing framework may provide a unifying perspective on several phenomena of infant development and learning that may seem unrelated at first sight. These phenomena include statistical learning principles, infants' motor and proprioceptive learning, and infants' basic understanding of their physical and social environment. We discuss how a predictive-processing perspective can advance the understanding of infants' early learning processes in theory, research, and application.
We are glad to introduce the Second Journal Club of Volume Five, Second Issue. This edition is focused on relevant studies published in the last few years in the field of resistance training, chosen by our Editorial Board members and their colleagues. We hope to stimulate your curiosity in this field and to share with you the passion for the sport, seen also from the scientific point of view. The Editorial Board members wish you an inspiring lecture.
We are glad to introduce the Second Journal Club of Volume Five, Second Issue. This edition is focused on relevant studies published in the last few years in the field of resistance training, chosen by our Editorial Board members and their colleagues. We hope to stimulate your curiosity in this field and to share with you the passion for the sport, seen also from the scientific point of view. The Editorial Board members wish you an inspiring lecture.
Background Recent shoulder injury prevention programs have utilized resistance exercises combined with different forms of instability, with the goal of eliciting functional adaptations and thereby reducing the risk of injury. However, it is still unknown how an unstable weight mass (UWM) affects the muscular activity of the shoulder stabilizers. Aim of the study was to assess neuromuscular activity of dynamic shoulder stabilizers under four conditions of stable and UWM during three shoulder exercises. It was hypothesized that a combined condition of weight with UWM would elicit greater activation due to the increased stabilization demand. Methods Sixteen participants (7 m/9 f) were included in this cross-sectional study and prepared with an EMG-setup for the: Mm. upper/lower trapezius (U.TA/L.TA), lateral deltoid (DE), latissimus dorsi (LD), serratus anterior (SA) and pectoralis major (PE). A maximal voluntary isometric contraction test (MVIC; 5 s.) was performed on an isokinetic dynamometer. Next, internal/external rotation (In/Ex), abduction/adduction (Ab/Ad) and diagonal flexion/extension (F/E) exercises (5 reps.) were performed with four custom-made-pipes representing different exercise conditions. First, the empty-pipe (P; 0.5 kg) and then, randomly ordered, water-filled-pipe (PW; 1 kg), weight-pipe (PG; 4.5 kg) and weight + water-filled-pipe (PWG; 4.5 kg), while EMG was recorded. Raw root-mean-square values (RMS) were normalized to MVIC (%MVIC). Differences between conditions for RMS%MVIC, scapular stabilizer (SR: U.TA/L.TA; U.TA/SA) and contraction (CR: concentric/eccentric) ratios were analyzed (paired t-test; p <= 0.05; Bonferroni adjusted alpha = 0.008). Results PWG showed significantly greater muscle activity for all exercises and all muscles except for PE compared to P and PW. Condition PG elicited muscular activity comparable to PWG (p > 0.008) with significantly lower activation of L.TA and SA in the In/Ex rotation. The SR ratio was significantly higher in PWG compared to P and PW. No significant differences were found for the CR ratio in all exercises and for all muscles. Conclusion Higher weight generated greater muscle activation whereas an UWM raised the neuromuscular activity, increasing the stabilization demands. Especially in the In/Ex rotation, an UWM increased the RMS%MVIC and SR ratio. This might improve training effects in shoulder prevention and rehabilitation programs.
Only the right noise?
(2020)
Seminal work by Werker and colleagues (Stager & Werker [1997]Nature, 388, 381-382) has found that 14-month-old infants do not show evidence for learning minimal pairs in the habituation-switch paradigm. However, when multiple speakers produce the minimal pair in acoustically variable ways, infants' performance improves in comparison to a single speaker condition (Rost & McMurray [2009]Developmental Science, 12, 339-349). The current study further extends these results and assesses how different kinds of input variability affect 14-month-olds' minimal pair learning in the habituation-switch paradigm testing German learning infants. The first two experiments investigated word learning when the labels were spoken by a single speaker versus when the labels were spoken by multiple speakers. In the third experiment we studied whether non-acoustic variability, implemented by visual variability of the objects presented together with the labels, would also affect minimal pair learning. We found enhanced learning in the multiple speakers compared to the single speaker condition, confirming previous findings with English-learning infants. In contrast, visual variability of the presented objects did not support learning. These findings both confirm and better delimit the beneficial role of speech-specific variability in minimal pair learning. Finally, we review different proposals on the mechanisms via which variability confers benefits to learning and outline what may be likely principles that underlie this benefit. We highlight among these the multiplicity of acoustic cues signalling phonemic contrasts and the presence of relations among these cues. It is in these relations where we trace part of the source for the apparent paradoxical benefit of variability in learning.
Only the right noise?
(2020)
Seminal work by Werker and colleagues (Stager & Werker [1997]Nature, 388, 381-382) has found that 14-month-old infants do not show evidence for learning minimal pairs in the habituation-switch paradigm. However, when multiple speakers produce the minimal pair in acoustically variable ways, infants' performance improves in comparison to a single speaker condition (Rost & McMurray [2009]Developmental Science, 12, 339-349). The current study further extends these results and assesses how different kinds of input variability affect 14-month-olds' minimal pair learning in the habituation-switch paradigm testing German learning infants. The first two experiments investigated word learning when the labels were spoken by a single speaker versus when the labels were spoken by multiple speakers. In the third experiment we studied whether non-acoustic variability, implemented by visual variability of the objects presented together with the labels, would also affect minimal pair learning. We found enhanced learning in the multiple speakers compared to the single speaker condition, confirming previous findings with English-learning infants. In contrast, visual variability of the presented objects did not support learning. These findings both confirm and better delimit the beneficial role of speech-specific variability in minimal pair learning. Finally, we review different proposals on the mechanisms via which variability confers benefits to learning and outline what may be likely principles that underlie this benefit. We highlight among these the multiplicity of acoustic cues signalling phonemic contrasts and the presence of relations among these cues. It is in these relations where we trace part of the source for the apparent paradoxical benefit of variability in learning.