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Previous studies suggested that electric and/or magnetic field fluctuations observed in the nighttime topside ionosphere at midlatitudes generally originate from quiet time nocturnal medium-scale traveling ionospheric disturbances (MSTIDs). However, decisive evidences for the connection between the two have been missing. In this study we make use of the multispacecraft observations of midlatitude magnetic fluctuations (MMFs) in the nighttime topside ionosphere by the Swarm constellation. The analysis results show that the area hosting MMFs is elongated in the NW-SE (NE-SW) direction in the Northern (Southern) Hemisphere. The elongation direction and the magnetic field polarization support that the area hosting MMFs is nearly field aligned. All these properties of MMFs suggest that they have close relationship with MSTIDs. Expectation values of root-mean-square field-aligned currents associated with MMFs are up to about 4nA/m(2). MMF coherency significantly drops for longitudinal distances of 1 degrees.
Patentpools
(2015)
Elisabeth Eppinger erforscht in diesem Buch aktuelle Patentpools, ihre Eigenschaften und alternative Lösungen zur gemeinsamen Nutzung von Patenten. Patentpools haben das Potenzial, Patentblockaden zu lösen und Innovationen zu fördern. Die Autorin diskutiert die Rolle von Patentkooperationen im Rahmen des strategischen Technologie- und Innovationsmanagements sowie der Innovationsförderung. Es wird gezeigt, welche strukturellen Faktoren, Motive und Charakteristika von Akteuren unterschiedliche Patentpools begünstigen
We propose a fibre-based approach for generation of optical frequency combs (OFCs) with the aim of calibration of astronomical spectrographs in the low and medium-resolution range. This approach includes two steps: in the first step, an appropriate state of optical pulses is generated and subsequently moulded in the second step delivering the desired OFC. More precisely, the first step is realised by injection of two continuous-wave (CW) lasers into a conventional single-mode fibre, whereas the second step generates a broad OFC by using the optical solitons generated in step one as initial condition. We investigate the conversion of a bichromatic input wave produced by two initial CW lasers into a train of optical solitons, which happens in the fibre used as step one. Especially, we are interested in the soliton content of the pulses created in this fibre. For that, we study different initial conditions (a single cosine-hump, an Akhmediev breather, and a deeply modulated bichromatic wave) by means of soliton radiation beat analysis and compare the results to draw conclusion about the soliton content of the state generated in the first step. In case of a deeply modulated bichromatic wave, we observed the formation of a collective soliton crystal for low input powers and the appearance of separated solitons for high input powers. An intermediate state showing the features of both, the soliton crystal and the separated solitons, turned out to be most suitable for the generation of OFC for the purpose of calibration of astronomical spectrographs.
The genetic integrity of each organism depends on the faithful segregation of its genome during mitosis. To meet this challenge, a cellular surveillance mechanism, termed the spindle assembly checkpoint (SAC), evolved that monitors the correct attachment of chromosomes and blocks progression through mitosis if corrections are needed. While the central role of the SAC for genome integrity is well established, its functional dissection has been hampered by the limited availability of appropriate small molecule inhibitors. Using a fluorescence polarization-based screen, we identify Mad2 inhibitor-1 (M2I-1), the first small molecule inhibitor targeting the binding of Mad2 to Cdc20, an essential protein-protein interaction (PPI) within the SAC. Based on computational and biochemical analyses, we propose that M2I-1 disturbs conformational dynamics of Mad2 critical for complex formation with Cdc20. Cellular studies revealed that M2I-1 weakens the SAC response, indicating that the compound might be active in cells. Thus, our study identifies the SAC specific complex formation between Mad2 and Cdc20 as a protein-protein interaction that can be targeted by small molecules.
Spatio-temporal control of cellular uptake achieved by photoswitchable cell-penetrating peptides
(2015)
The selective uptake of compounds into specific cells of interest is a major objective in cell biology and drug delivery. By incorporation of a novel, thermostable azobenzene moiety we generated peptides that can be switched optically between an inactive state and an active, cell-penetrating state with excellent spatio-temporal control.
Zweimal Kyros
(2015)
«Kyros» taucht als Fürstenname dreimal in der Überlieferung des Perserreiches auf. Der Historiker Xenophon von Athen (427–ca. 355 v. Chr.) hat in seinen Schriften über zwei Träger dieses Namens berichtet und sie durchaus unterschiedlich bewertet: Kyros II. («der Große»), Mehrer des Reiches, sowie ein Jahrhundert später Kyros, Sohn des Dareios und jüngerer Bruder des Perserkönigs Artaxerxes II. Der ältere Kyros ist namengebender Protagonist eines Fürstenspiegels (der Kyropädie), wird also grundsätzlich positiv und als ein Vorbild für andere dargestellt. Am erfolglosen Kampf des jüngeren Kyros um die Krone des Perserreichs hatte Xenophon als Offizier griechischer Söldner selbst teilgenommen. Aus dem Vergleich von Darstellung und Bewertung der beiden Fürsten lassen sich die Ansprüche Xenophons an einen idealen Herrscher ableiten, was hier unternommen werden soll. Zugleich ermöglichen diese Ergebnisse, Xenophon als Historiker und politischen Denker in der zeitgenössischen Debatte um die beste Staatsform einzubetten.
The United Nations Security Council (UNSC) is one of the most important multilateral institutions having the ambition to shape global governance and the only organ of the global community that can adopt legally binding resolutions for the maintenance of international peace and security and, if necessary, authorize the use of force. Created in the aftermath of World War II by its victors, the UNSC’s constellation looks increasingly anachronistic, however, in light of the changing global distribution of power. Adapting the institutional structure and decision-making procedures of the UNSC has proven to be one of the most difficult challenges of the last decades, while it is the institution that has probably been faced with the most vociferous calls for reform. Although there have been changes to the informal ways in which outside actors are drawn into the UNSC’s work and activities, many of the major players in the current international system seem to be deprived from equal treatment in its core patterns of decision-making. Countries such as Brazil, Germany, India and Japan, alongside emerging African nations such as Nigeria and South Africa, are among the states eager to secure permanent representation on the Council. By comparison, selected BRICS countries, China and Russia - in contrast to their role in other multilateral institutions - are permanent members of the UNSC and with this, have been “insiders” for a long time. This renders the situation of the UNSC different from global institutions, in which traditionally, Western powers have dominated the agenda.
Prozessorientierte Didaktik
(2015)
n diesem Beitrag finden Sie ein von mir entwickeltes Konzept zum Lehren und Lernen in der Schule1. Ich nenne dieses Konzept prozessorientierte Didaktik. Ich habe die Hoffnung, gemeinsam mit Ihnen als Lehrer oder Lehramtsstudierende, aber auch mit Eltern, Wissenschaftlern, Experten für Bildung und Schülern, einen Beitrag zur Verbesserung unserer Schulpraxis zu leisten. Dass Schule sich bereits im Wandel befindet und wunderbar gelingen kann, sieht man beispielsweise an den Preisträgern des Deutschen Schulpreises. Leider sind diese Schulen immer noch in der Minderheit. Dieses Verhältnis umzukehren ist eine unserer größten Bildungsaufgaben für die nächsten Jahrzehnte.
It is well established in language acquisition research that monolingual children and adult second language learners misinterpret sentences with the universal quantifier every and make quantifier-spreading errors that are attributed to a preference for a match in number between two sets of objects. The present Visual World eye-tracking study tested bilingual heritage Russian-English adults and investigated how they interpret of sentences like Every alligator lies in a bathtub in both languages. Participants performed a sentence-picture verification task while their eye movements were recorded. Pictures showed three pairs of alligators in bathtubs and two extra objects: elephants (Control condition), bathtubs (Overexhaustive condition), or alligators (Underexhaustive condition). Monolingual adults performed at ceiling in all conditions. Heritage language (HL) adults made 20% q-spreading errors, but only in the Overexhaustive condition, and when they made an error they spent more time looking at the two extra bathtubs during the Verb region. We attribute q-spreading in HL speakers to cognitive overload caused by the necessity to integrate conflicting sources of information, i.e. the spoken sentences in their weaker, heritage, language and attention-demanding visual context, that differed with respect to referential salience.
Permafrost inundated since the last glacial maximum is degrading, potentially releasing trapped or stabilized greenhouse gases, but few observations of the depth of ice-bonded permafrost (IBP) below the seafloor exist for most of the arctic continental shelf. We use spectral ratios of the ambient vibration seismic wavefield, together with estimated shear wave velocity from the dispersion curves of surface waves, for estimating the thickness of the sediment overlying the IBP. Peaks in spectral ratios modeled for three-layered 1-D systems correspond with varying thickness of the unfrozen sediment. Seismic receivers were deployed on the seabed around Muostakh Island in the central Laptev Sea, Siberia. We derive depths of the IBP between 3.7 and 20.7m15%, increasing with distance from the shoreline. Correspondence between expected permafrost distribution, modeled response, and observational data suggests that the method is promising for the determination of the thickness of unfrozen sediment.
Many foresight studies concentrate on technological foresight and its impact at the organizational level. However, often these studies overlook the soft factor of employee competences which is critical to adopting technological and organizational changes and to developing the necessary innovation capabilities. This study investigates the theoretical and methodological underdeveloped relationship between technological innovation and social initiated change and the impact on individual competences in a dynamic sector. The setting of our study is the turbulent creative industries as a whole, where creative and artistic expression merges with changing technological progress. In a scenario study we mainly conducted in 2010, we developed a scenario model for competences to combine individual competences with a scenario approach to investigate how competences are important to the sector shift or need to be enhanced in the future. We use primary qualitative data from expert interviews and workshops and secondary data from industry reports to identify thirty-seven influence factors. An influence matrix calculation and a cluster analysis are used to project three different scenarios presenting how future developments of the creative industries will influence the competences needed for creative occupations. Now, five years later, we reflect the accuracy of the developed scenarios via a comparison of today's situation with the situation in the scenarios. We discuss theoretical contributions for the foresight literature and practical implementations for the future of work in general, and in particular for the creative industries case. (C) 2015 Elsevier Inc. All rights reserved.
Parental effects (PE) can be adaptive and improve offspring performance when parents and offspring experience similar environmental conditions. However, it is unknown whether adaptive PE exist also in habitats where such similarity is unlikely due to strong temporal variation. In particular, we do not know whether PE can adapt offspring to fluctuating levels of neighbour competition in such habitats. Here, we tested for adaptive PE in terms of two key environmental factors in a semi-arid annual system, competition and drought. While rainfall was stochastic in the study site, the competitive environment was partly predictable: higher plant densities followed after favourable (rainy) years due to high seed production. We therefore expected PE to adapt the offspring's competitive ability to these (predictable) fluctuations in plant densities, rather than to adapt the offspring's drought tolerance to the (unpredictable) occurrence of intensified drought. Parental plants of Biscutella didyma, an annual Brassicaceae, were raised under favourable watering and under drought conditions. Offspring performance was then tested under a full-factorial combination of two neighbour regimes and six watering levels in the glasshouse. Offspring of parents grown under favourable conditions were stronger competitors. This was associated with a small shift in phenology but not with higher parental seed provisioning. Offspring from parents grown under drought showed no improved drought tolerance. Moreover, no PE were detectable when offspring were grown without neighbours. Our results suggest a novel path of adaptive PE: higher competitive ability was induced in offspring that were more likely to experience high neighbour densities. Together with the lack of adaptive PE towards drought tolerance, this emphasizes that a correlation between parental and offspring environment is crucial for adaptive PE to evolve. Our results also call for the inclusion of competitive effects in future PE studies.Synthesis. This study demonstrates the important role of adaptive PE for plant fitness (regarding competition) but also their limits (regarding drought) in temporally variable environments, based on the predictability of the respective environmental factor.
Warum Religion?
(2015)
Die meisten Religionen versprechen ein Leben nachdem Tod, in dem es glücklicher oder gerechter oder sonst wie besser zugehen soll als auf der Erde. Wie schön wäre es, wenn wir wirklich auf ein ewiges Leben in der Gegenwart Gottes oder auf ein neues Leben in einem unverbrauchten Körper hoffen könnten! Wir könnten gelassener mit irdischem Scheitern umgehen und eher loslassen, wenn wir sicher sein könnten, dass alles, was uns hier widerfährt, nur ein Übergang in eine bessere Existenz ist. Aber lenken die Religionen mit solchen Versprechungen nicht nur von irdischen Missständen ab? Mit solchen Argumenten sind die Religionen als Opium des Volkes in Sippenhaft genommen worden. Jenseits dessen stellt sich das Problem des szientistischen Zweifels. Wie soll mich eine religiöse Überzeugung durch mein Leben tragen, wenn die Überzeugung nicht überzeugend ist? Ist es wirklich glaubwürdig, dass Jesus von Nazareth nach drei Tagen im Grab wieder auferstanden sein soll? Wenn ich das nicht glauben kann, kann ich auch nicht an meine eigene Auferstehung glauben. Wohl kaum eine andere Religionsphilosophie stellt eine so enge Beziehung zwischen religiösem Glauben und irdischem Wohlergehen her wie die des amerikanischen Pragmatismus: Bei William James heißt es ausdrücklich, dass ein religiöser Glaube das Leben »leicht und glücklich« machen könne. Und kaum eine Religionsphilosophie benennt so deutlich das Problem des szientistischen Zweifels. Im ersten Teil des Buches, Religion, pragmatisch betrachtet, befassen sich Johannes Ev. Hafner, Christian Thies und Christoph Türcke mit der Funktion von Religion in unserer Gesellschaft und in unseren konkreten Lebensvollzügen. Im zweiten Teil stellen Michael Blume, Matthias Jung, Ludwig Nagl und Marie-Luise Raters Positionen der pragmatistischen Religionsphilosophie auf den Prüfstand.
Aims. To explore the origin of high-velocity gas in the direction of the Large Magellanic Cloud, (LMC) we analyze absorption lines in the ultraviolet spectrum of a Galactic halo star that is located in front of the LMC at d = 9.2(-7.2)(+4.1) kpc distance.
Methods. We study the velocity-component structure of low and intermediate metal ions (CII, SiII, SiIII) in the spectrum of RXJ0439.8-6809, as obtained with the Cosmic Origins Spectrograph (COS) onboard the Hubble Space Telescope (HST), and measure equivalent widths and column densities for these ions. We supplement our COS data with a Far-Ultraviolet Spectroscopic Explorer (FUSE) spectrum of the nearby LMC star Sk-69 59 and with Hi 21 cm data from the Leiden-Argentina-Bonn (LAB) survey.
Results. Metal absorption toward RXJ0439.8-6809 is unambiguously detected in three different velocity components near v(LSR) = 0, + 60, and + 150 km s(-1). The presence of absorption proves that all three gas components are situated in front of the star, thus located in the disk and inner halo of the Milky Way. For the high-velocity cloud (HVC) at v(LSR) = + 150 km s(-1), we derive an oxygen abundance of [O/H] = -0.63 (similar to 0.2 solar) from the neighboring Sk-69 59 sight line, in accordance with previous abundance measurements for this HVC. From the observed kinematics we infer that the HVC hardly participates in the Galactic rotation.
Conclusions. Our study shows that the HVC toward the LMC represents a Milky Way halo cloud that traces low column density gas with relatively low metallicity. We rule out scenarios in which the HVC represents material close to the LMC that stems from a LMC outflow.
Don't worry - be happy?
(2015)
We attempt to clarify a great deal of confusion in the literature on what a passive is, and what counts as a passive in different languages. We do this through a detailed investigation of what has been identified as a passive in Vietnamese, sentences with the morphemes bi and duoc. We also compare these to Mandarin Chinese bei. We show that these morphemes are not passive at all: like English auxiliaries, they may occur with either an active complement or a passive one. We clarify this point and what it means to be a passive. Second, sentences with these morphemes and the corresponding sentences without them are truth-conditionally equivalent. We show that the extra meaning they convey is a type of projective, or not-at-issue, meaning that is separate from the at-issue content of the sentence. We provide a detailed syntactic and semantic analysis of Vietnamese, and give arguments for this analysis. We propose that there is no movement in Vietnamese, but there is in Chinese, and this difference accounts for differences between the two languages. We also clarify what agent-oriented adverbs of the 'deliberately' type show, and draw conclusions about English get passives and tough constructions. (C) 2015 Elsevier B.V. All rights reserved.
The Strange-tailed Tyrant Alectrurus risora (Aves: Tyrannidae) is an endemic species of southern South American grasslands that suffered a 90% reduction of its original distribution due to habitat transformation. This has led the species to be classified as globally Vulnerable. By the beginning of the last century, populations were partially migratory and moved south during the breeding season. Currently, the main breeding population inhabits the Ibera wetlands in the province of Corrientes, north-east Argentina, where it is resident all year round. There are two remaining small populations in the province of Formosa, north-east Argentina, and in southern Paraguay, which are separated from the main population by the Parana-Paraguay River and its continuous riverine forest habitat. The populations of Corrientes and Formosa are separated by 300 km and the grasslands between populations are non-continuous due to habitat transformation. We used mtDNA sequences and eight microsatellite loci to test if there were evidences of genetic isolation between Argentinean populations. We found no evidence of genetic structure between populations (Phi(ST) = 0.004, P = 0.32; Fst = 0.01, P = 0.06), which can be explained by either retained ancestral polymorphism or by dispersal between populations. We found no evidence for a recent demographic bottleneck in nuclear loci. Our results indicate that these populations could be managed as a single conservation unit on a regional scale. Conservation actions should be focused on preserving the remaining network of areas with natural grasslands to guarantee reproduction, dispersal and prevent further decline of populations.
Island biotas emerge from the interplay between colonisation, speciation and extinction and are often the scene of spectacular adaptive radiations. A common assumption is that insular diversity is at a dynamic equilibrium, but for remote islands, such as Hawaii or Galápagos, this idea remains untested. Here, we reconstruct the temporal accumulation of terrestrial bird species of the Galápagos using a novel phylogenetic method that estimates rates of biota assembly for an entire community. We show that species richness on the archipelago is in an ascending phase and does not tend towards equilibrium. The majority of the avifauna diversifies at a slow rate, without detectable ecological limits. However, Darwin's finches form an exception: they rapidly reach a carrying capacity and subsequently follow a coalescent-like diversification process. Together, these results suggest that avian diversity of remote islands is rising, and challenge the mutual exclusivity of the non-equilibrium and equilibrium ecological paradigms.
Frankreich 1958: Der Algerienkrieg eskaliert, die links-liberale Regierung implodiert und reicht die Macht an General Charles de Gaulle weiter. Der hebt im Oktober die V. Republik aus der Taufe - und die französische Linke gesteht damit ihre Ohnmacht ein. Die Sozialisten haben den Machtantritt des konservativen Generals nicht verhindert, sondern diesen sogar mit angezettelt. Auch die Kommunisten sind isoliert und kämpfen mit dem stalinistischen Erbe. Einige Genossen erkennen ihre sozialistische Bewegung nicht wieder und beschließen, eine neue linke Bewegung aufbauen. Sie wollen de Gaulle und den Krieg offen bekämpfen, "veraltete" linke Ideologien über Bord werfen und ein "Labor" für neues linkes Denken schaffen. Parteimitglieder der Altkommunisten, Sozialisten und Trotzkisten, aber auch Künstler, Philosophen und Schriftsteller wurden Teil dieser heterogenen Bewegung, die heute als Neue Linke bezeichnet wird. Der interessierte Leser begreift nun die Ideengeschichte dieser Neuen französischen Linken, die nicht nur einen starken Einfluss auf die Ereignisse um 1968 in Frankreich ausübte, sondern deren Ansätze noch bis heute im linken Spektrum, inner- wie außerparteilich, für Diskussionsstoff sorgen.
lower development is controlled by the action of key regulatory transcription factors of the MADS-domain family. The function of these factors appears to be highly conserved among species based on mutant phenotypes. However, the conservation of their downstream processes is much less well understood, mostly because the evolutionary turnover and variation of their DNA-binding sites (BSs) among plant species have not yet been experimentally determined. Here, we performed comparative ChIP (chromatin immunoprecipitation)-seq experiments of the MADS-domain transcription factor SEPALLATA3 (SEP3) in two closely related Arabidopsis species: Arabidopsis thaliana and A. lyrata which have very similar floral organ morphology. We found that BS conservation is associated with DNA sequence conservation, the presence of the CArG-box BS motif and on the relative position of the BS to its potential target gene. Differences in genome size and structure can explain that SEP3 BSs in A. lyrata can be located more distantly to their potential target genes than their counterparts in A. thaliana. In A. lyrata, we identified transposition as a mechanism to generate novel SEP3 binding locations in the genome. Comparative gene expression analysis shows that the loss/gain of BSs is associated with a change in gene expression. In summary, this study investigates the evolutionary dynamics of DNA BSs of a floral key-regulatory transcription factor and explores factors affecting this phenomenon.
Welcher Diskurs wird um Jungenarbeit als geschlechtssensible pädagogische Arbeit mit männlichen Kindern und Jugendlichen und deren Umsetzung in kurzzeitpädagogischen außerunterrichtlichen Angeboten geführt? Thomas Viola Rieske geht dieser Frage nach und legt nahe, dass Normativität als unausweichlicher Bestandteil pädagogischer Praxis anerkannt und zugleich kritisch reflektiert werden muss, um Jungen in ihrer Entwicklung stärken zu können. Er diskutiert die verschiedenen geschlechtertheoretischen und pädagogischen Grundpositionen, die im Fachdiskurs über Jungenarbeit bestehen und untersucht die Umsetzung von Jungenarbeit. Er zeigt auf, dass die Teilnehmer der beobachteten Jungenseminare einerseits zu einem partnerschaftlichen, normenkritischen und direkten Kontakt mit sich und anderen befähigt werden, andererseits aber auch Zuschreibungen, Grenzüberschreitungen und ein Übergehen ihrer Bedürfnisse erfahren.
Der Businessplan
(2015)
Entrepreneurial Marketing
(2015)
Finanzplanung
(2015)