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The primary function of leaves is to provide an interface between plants and their environment for gas exchange, light exposure and thermoregulation. Leaves have, therefore a central contribution to plant fitness by allowing an efficient absorption of sunlight energy through photosynthesis to ensure an optimal growth. Their final geometry will result from a balance between the need to maximize energy uptake while minimizing the damage caused by environmental stresses. This intimate relationship between leaf and its surroundings has led to an enormous diversification in leaf forms. Leaf shape varies between species, populations, individuals or even within identical genotypes when those are subjected to different environmental conditions. For instance, the extent of leaf margin dissection has, for long, been found to inversely correlate with the mean annual temperature, such that Paleobotanists have used models based on leaf shape to predict the paleoclimate from fossil flora. Leaf growth is not only dependent on temperature but is also regulated by many other environmental factors such as light quality and intensity or ambient humidity. This raises the question of how the different signals can be integrated at the molecular level and converted into clear developmental decisions. Several recent studies have started to shed the light on the molecular mechanisms that connect the environmental sensing with organ-growth and patterning. In this review, we discuss the current knowledge on the influence of different environmental signals on leaf size and shape, their integration as well as their importance for plant adaptation.
Objective Depression after stroke and myocardial infarction (MI) is common but often assumed to be undertreated without reliable evidence being available. Thus, we aimed to determine treatment rates and investigate the application of guidelines in these conditions. Methods Databases MEDLINE, EMBASE, PsycInfo, Web of Science, CINAHL, and Scopus were systematically searched without language restriction from inception to June 30, 2017. Prospective observational studies with consecutive recruitment reporting any antidepressant treatment in adults with depression after stroke or MI were included. Random-effects models were used to calculate pooled estimates of treatment rates. Results Fifty-five studies reported 32 stroke cohorts (n = 8938; pooled frequency of depression = 34%, 95% confidence interval [CI] = 29%-38%) and 17 MI cohorts (n = 10,767; pooled frequency of depression = 24%, 95% CI = 20%-28%). In 29 stroke cohorts, 24% (95% CI = 20%-27%) of 2280 depressed people used antidepressant medication. In 15 MI cohorts, 14% (95% CI = 8%-19%) of 2381 depressed people used antidepressant medication indicating a lower treatment rate than in stroke. Two studies reported use of psychosocial interventions, indicating that less than 10% of participants were treated. Conclusions Despite the high frequency of depression after stroke and MI and the existence of efficacious treatment strategies, people often remain untreated. Innovative strategies are needed to increase the use of effective antidepressive interventions in patients with cardiovascular disease.
We review the evidence for a putative early 21st-century divergence between global mean surface temperature (GMST) and Coupled Model Intercomparison Project Phase 5 (CMIP5) projections. We provide a systematic comparison between temperatures and projections using historical versions of GMST products and historical versions of model projections that existed at the times when claims about a divergence were made. The comparisons are conducted with a variety of statistical techniques that correct for problems in previous work, including using continuous trends and a Monte Carlo approach to simulate internal variability. The results show that there is no robust statistical evidence for a divergence between models and observations. The impression of a divergence early in the 21st century was caused by various biases in model interpretation and in the observations, and was unsupported by robust statistics.
Reviews and syntheses
(2018)
The cycling of carbon (C) between the Earth surface and the atmosphere is controlled by biological and abiotic processes that regulate C storage in biogeochemical compartments and release to the atmosphere. This partitioning is quantified using various forms of C-use efficiency (CUE) - the ratio of C remaining in a system to C entering that system. Biological CUE is the fraction of C taken up allocated to biosynthesis. In soils and sediments, C storage depends also on abiotic processes, so the term C-storage efficiency (CSE) can be used. Here we first review and reconcile CUE and CSE definitions proposed for autotrophic and heterotrophic organisms and communities, food webs, whole ecosystems and watersheds, and soils and sediments using a common mathematical framework. Second, we identify general CUE patterns; for example, the actual CUE increases with improving growth conditions, and apparent CUE decreases with increasing turnover. We then synthesize > 5000CUE estimates showing that CUE decreases with increasing biological and ecological organization - from uni-cellular to multicellular organisms and from individuals to ecosystems. We conclude that CUE is an emergent property of coupled biological-abiotic systems, and it should be regarded as a flexible and scale-dependent index of the capacity of a given system to effectively retain C.
Knowledge of the present-day crustal in-situ stress field is a key for the understanding of geodynamic processes such as global plate tectonics and earthquakes. It is also essential for the management of geo-reservoirs and underground storage sites for energy and waste. Since 1986, the World Stress Map (WSM) project has systematically compiled the orientation of maximum horizontal stress (S-Hmax). For the 30th anniversary of the project, the WSM database has been updated significantly with 42,870 data records which is double the amount of data in comparison to the database release in 2008. The update focuses on areas with previously sparse data coverage to resolve the stress pattern on different spatial scales. In this paper, we present details of the new WSM database release 2016 and an analysis of global and regional stress pattern. With the higher data density, we can now resolve stress pattern heterogeneities from plate-wide to local scales. In particular, we show two examples of 40 degrees-60 degrees S-Hmax rotations within 70 km. These rotations can be used as proxies to better understand the relative importance of plate boundary forces that control the long wave-length pattern in comparison to regional and local controls of the crustal stress state. In the new WSM project phase IV that started in 2017, we will continue to further refine the information on the S-Hmax orientation and the stress regime. However, we will also focus on the compilation of stress magnitude data as this information is essential for the calibration of geomechanical-numerical models. This enables us to derive a 3-D continuous description of the stress tensor from point-wise and incomplete stress tensor information provided with the WSM database. Such forward models are required for safety aspects of anthropogenic activities in the underground and for a better understanding of tectonic processes such as the earthquake cycle.
This work reviews the literature on an alleged global warming 'pause' in global mean surface temperature (GMST) to determine how it has been defined, what time intervals are used to characterise it, what data are used to measure it, and what methods used to assess it. We test for 'pauses', both in the normally understood meaning of the term to mean no warming trend, as well as for a 'pause' defined as a substantially slower trend in GMST. The tests are carried out with the historical versions of GMST that existed for each pause-interval tested, and with current versions of each of the GMST datasets. The tests are conducted following the common (but questionable) practice of breaking the linear fit at the start of the trend interval ('broken' trends), and also with trends that are continuous with the data bordering the trend interval. We also compare results when appropriate allowance is made for the selection bias problem. The results show that there is little or no statistical evidence for a lack of trend or slower trend in GMST using either the historical data or the current data. The perception that there was a 'pause' in GMST was bolstered by earlier biases in the data in combination with incomplete statistical testing.
Children’s motor competence is known to have a determinant role in learning and engaging later in complex motor skills and, thus, in physical activity. The development of adequate motor competence is a central aim of physical education, and assuring that pupils are learning and developing motor competence depends on accurate assessment protocols. The MOBAK 1 test battery is a recent instrument developed to assess motor competence in primary physical education. This study used the MOBAK 1 to explore motor competence levels and gender differences among 249 (Mage = 6.3, SD = 0.5 years; 127 girls and 122 boys) Grade 1 primary school Portuguese children. On independent sample t tests, boys presented higher object movement motor competence than girls (boys: M = 5.8, SD = 1.7; girls: M = 4.0, SD = 1.7; p < .001), while girls were more proficient among self-movement skills (girls: M = 5.1, SD = 1.8; boys: M = 4.3, SD = 1.7; p < .01). On “total motor competence,” boys (M = 10.3, SD = 2.6) averaged one point ahead of girls (M = 9.1, SD = 2.9). The percentage of girls in the first quartile of object movement was 18.9%, while, for “self movement,” the percentage of boys in the first quartile was almost double that of girls (30.3% and 17.3%, respectively). The confirmatory model to test for construct validity confirmed the assumed theoretical two-factor structure of MOBAK 1 test items in this Portuguese sample. These results support the MOBAK 1 instrument for assessing motor competence and highlighted gender differences, of relevance to intervention efforts.
As a tumor suppressor and the most frequently mutated gene in cancer, p53 is among the best-described molecules in medical research. As cancer is in most cases an age-related disease, it seems paradoxical that p53 is so strongly conserved from early multicellular organisms to humans. A function not directly related to tumor suppression, such as the regulation of metabolism in nontransformed cells, could explain this selective pressure. While this role of p53 in cellular metabolism is gradually emerging, it is imperative to dissect the tissue-and cell-specific actions of p53 and its downstream signaling pathways. In this review, we focus on studies reporting p53's impact on adipocyte development, function, and maintenance, as well as the causes and consequences of altered p53 levels in white and brown adipose tissue (AT) with respect to systemic energy homeostasis. While whole body p53 knockout mice gain less weight and fat mass under a high-fat diet owing to increased energy expenditure, modifying p53 expression specifically in adipocytes yields more refined insights: (1) p53 is a negative regulator of in vitro adipogenesis; (2) p53 levels in white AT are increased in diet-induced and genetic obesity mouse models and in obese humans; (3) functionally, elevated p53 in white AT increases senescence and chronic inflammation, aggravating systemic insulin resistance; (4) p53 is not required for normal development of brown AT; and (5) when p53 is activated in brown AT in mice fed a high-fat diet, it increases brown AT temperature and brown AT marker gene expression, thereby contributing to reduced fat mass accumulation. In addition, p53 is increasingly being recognized as crucial player in nutrient sensing pathways. Hence, despite existence of contradictory findings and a varying density of evidence, several functions of p53 in adipocytes and ATs have been emerging, positioning p53 as an essential regulatory hub in ATs. Future studies need to make use of more sophisticated in vivo model systems and should identify an AT-specific set of p53 target genes and downstream pathways upon different (nutrient) challenges to identify novel therapeutic targets to curb metabolic diseases
Up to now pathological health anxiety has been classified primarily as a somatoform disorder or a somatic symptom disorder in ICD and DSM. Theoretical and empirical evidence, however, suggest that pathological health anxiety basically represents an anxiety disorder. In this paper, it is argued that deficits in the treatment and perception of patients with pathological health anxiety as "difficult patients" are partly attributable to a lack of clarity in terms of nosology and with respect to central mechanisms of etiology and pathogenesis. Based on novel theoretical approaches for the explanation of pathological health anxiety, suggestions for an improved therapeutic practice are outlined. This approach focuses on a more intensive use of exposure-based treatment elements that are oriented to the inhibitory learning approach, which has already proven its effectiveness for other anxiety disorders.
Serious knee pain and related disability have an annual prevalence of approximately 25% on those over the age of 55 years. As curative treatments for the common knee problems are not available to date, knee pathologies typically progress and often lead to osteoarthritis (OA). While the roles that the meniscus plays in knee biomechanics are well characterized, biological mechanisms underlying meniscus pathophysiology and roles in knee pain and OA progression are not fully clear. Experimental treatments for knee disorders that are successful in animal models often produce unsatisfactory results in humans due to species differences or the inability to fully replicate disease progression in experimental animals. The use of animals with spontaneous knee pathologies, such as dogs, can significantly help addressing this issue. As microscopic and macroscopic anatomy of the canine and human menisci are similar, spontaneous meniscal pathologies in canine patients are thought to be highly relevant for translational medicine. However, it is not clear whether the biomolecular mechanisms of pain, degradation of extracellular matrix, and inflammatory responses are species dependent. The aims of this review are (1) to provide an overview of the anatomy, physiology, and pathology of the human and canine meniscus, (2) to compare the known signaling pathways involved in spontaneous meniscus pathology between both species, and (3) to assess the relevance of dogs with spontaneous meniscal pathology as a translational model. Understanding these mechanisms in human and canine meniscus can help to advance diagnostic and therapeutic strategies for painful knee disorders and improve clinical decision making.
We analyze a general class of self-adjoint difference operators H-epsilon = T-epsilon + V-epsilon on l(2)((epsilon Z)(d)), where V-epsilon is a multi-well potential and v(epsilon) is a small parameter. We give a coherent review of our results on tunneling up to new sharp results on the level of complete asymptotic expansions (see [30-35]). Our emphasis is on general ideas and strategy, possibly of interest for a broader range of readers, and less on detailed mathematical proofs. The wells are decoupled by introducing certain Dirichlet operators on regions containing only one potential well. Then the eigenvalue problem for the Hamiltonian H-epsilon is treated as a small perturbation of these comparison problems. After constructing a Finslerian distance d induced by H-epsilon, we show that Dirichlet eigenfunctions decay exponentially with a rate controlled by this distance to the well. It follows with microlocal techniques that the first n eigenvalues of H-epsilon converge to the first n eigenvalues of the direct sum of harmonic oscillators on R-d located at several wells. In a neighborhood of one well, we construct formal asymptotic expansions of WKB-type for eigenfunctions associated with the low-lying eigenvalues of H-epsilon. These are obtained from eigenfunctions or quasimodes for the operator H-epsilon acting on L-2(R-d), via restriction to the lattice (epsilon Z)(d). Tunneling is then described by a certain interaction matrix, similar to the analysis for the Schrodinger operator (see [22]), the remainder is exponentially small and roughly quadratic compared with the interaction matrix. We give weighted l(2)-estimates for the difference of eigenfunctions of Dirichlet-operators in neighborhoods of the different wells and the associated WKB-expansions at the wells. In the last step, we derive full asymptotic expansions for interactions between two "wells" (minima) of the potential energy, in particular for the discrete tunneling effect. Here we essentially use analysis on phase space, complexified in the momentum variable. These results are as sharp as the classical results for the Schrodinger operator in [22].
Singlet oxygen can be released in the dark in nearly quantitative yield from endoperoxides of naphthalenes, anthracenes and pyridones as an alternative to its generation by photosensitization. Recently, new donor systems have been designed which operate at very low temperatures but which are prepared from their parent forms at acceptable rates. Enhancement of the reactivity of donors is conveniently achieved by the design of the substitution pattern or through the use of plasmonic heating of nanoparticle-bound donors. The most important aim of these donor molecules is to transfer singlet oxygen in a controlled and directed manner to a target. Low temperatures and the linking between donors and acceptors reduce the random walk of oxygen and may force an attack at the desired position. By using chiral donor systems, new stereocenters might be introduced into prochiral acceptors.
Plant roots control uptake of water and nutrients and cope with environmental challenges. The root epidermis provides the first selective interface for nutrient absorption, while the endodermis produces the main apoplastic diffusion barrier in the form of a structure called the Casparian strip. The positioning of root hairs on epidermal cells, and of the Casparian strip around endodermal cells, requires asymmetries along cellular axes (cell polarity). Cell polarity is termed planar polarity, when coordinated within the plane of a given tissue layer. Here, we review recent molecular advances towards understanding both the polar positioning of the proteo-lipid membrane domain instructing root hair initiation, and the cytoskeletal, trafficking and polar tethering requirements of proteins at outer or inner plasma membrane domains. Finally, we highlight progress towards understanding mechanisms of Casparian strip formation and underlying endodermal cell polarity.
Moving Beyond ERP Components
(2018)
Relationships between neuroimaging measures and behavior provide important clues about brain function and cognition in healthy and clinical populations. While electroencephalography (EEG) provides a portable, low cost measure of brain dynamics, it has been somewhat underrepresented in the emerging field of model-based inference. We seek to address this gap in this article by highlighting the utility of linking EEG and behavior, with an emphasis on approaches for EEG analysis that move beyond focusing on peaks or "components" derived from averaging EEG responses across trials and subjects (generating the event-related potential, ERP). First, we review methods for deriving features from EEG in order to enhance the signal within single-trials. These methods include filtering based on user-defined features (i.e., frequency decomposition, time-frequency decomposition), filtering based on data-driven properties (i.e., blind source separation, BSS), and generating more abstract representations of data (e.g., using deep learning). We then review cognitive models which extract latent variables from experimental tasks, including the drift diffusion model (DDM) and reinforcement learning (RL) approaches. Next, we discuss ways to access associations among these measures, including statistical models, data-driven joint models and cognitive joint modeling using hierarchical Bayesian models (HBMs). We think that these methodological tools are likely to contribute to theoretical advancements, and will help inform our understandings of brain dynamics that contribute to moment-to-moment cognitive function.
Lifestyle-related disorders, such as the metabolic syndrome, have become a primary risk factor for the development of liver pathologies that can progress from hepatic steatosis, hepatic insulin resistance, steatohepatitis, fibrosis and cirrhosis, to the most severe condition of hepatocellular carcinoma (HCC). While the prevalence of liver pathologies is steadily increasing in modern societies, there are currently no approved drugs other than chemotherapeutic intervention in late stage HCC. Hence, there is a pressing need to identify and investigate causative molecular pathways that can yield new therapeutic avenues. The transcription factor p53 is well established as a tumor suppressor and has recently been described as a central metabolic player both in physiological and pathological settings. Given that liver is a dynamic tissue with direct exposition to ingested nutrients, hepatic p53, by integrating cellular stress response, metabolism and cell cycle regulation, has emerged as an important regulator of liver homeostasis and dysfunction. The underlying evidence is reviewed herein, with a focus on clinical data and animal studies that highlight a direct influence of p53 activity on different stages of liver diseases. Based on current literature showing that activation of p53 signaling can either attenuate or fuel liver disease, we herein discuss the hypothesis that, while hyper-activation or loss of function can cause disease, moderate induction of hepatic p53 within physiological margins could be beneficial in the prevention and treatment of liver pathologies. Hence, stimuli that lead to a moderate and temporary p53 activation could present new therapeutic approaches through several entry points in the cascade from hepatic steatosis to HCC.
Two decades ago, sphingosine 1-phosphate (S1P) was discovered as a novel bioactive molecule that regulates a variety of cellular functions. The plethora of S1P-mediated effects is due to the fact that the sphingolipid not only modulates intracellular functions but also acts as a ligand of G protein-coupled receptors after secretion into the extracellular environment. In the plasma, S1P is found in high concentrations, modulating immune cell trafficking and vascular endothelial integrity. The liver is engaged in modulating the plasma S1P content, as it produces apolipoprotein M, which is a chaperone for the S1P transport. Moreover, the liver plays a substantial role in glucose and lipid homeostasis. A dysfunction of glucose and lipid metabolism is connected with the development of liver diseases such as hepatic insulin resistance, non-alcoholic fatty liver disease, or liver fibrosis. Recent studies indicate that S1P is involved in liver pathophysiology and contributes to the development of liver diseases. In this review, the current state of knowledge about S1P and its signaling in the liver is summarized with a specific focus on the dysregulation of S1P signaling in obesity-mediated liver diseases. Thus, the modulation of S1P signaling can be considered as a potential therapeutic target for the treatment of hepatic diseases.
A challenge for eco-evolutionary research is to better understand the effect of climate and landscape changes on species and their distribution. Populations of species can respond to changes in their environment through local genetic adaptation or plasticity, dispersal, or local extinction. The individual-based modeling (IBM) approach has been repeatedly applied to assess organismic responses to environmental changes. IBMs simulate emerging adaptive behaviors from the basic entities upon which both ecological and evolutionary mechanisms act. The objective of this review is to summarize the state of the art of eco-evolutionary IBMs and to explore to what degree they already address the key responses of organisms to environmental change. In this, we identify promising approaches and potential knowledge gaps in the implementation of eco-evolutionary mechanisms to motivate future research. Using mainly the ISI Web of Science, we reveal that most of the progress in eco-evolutionary IBMs in the last decades was achieved for genetic adaptation to novel local environmental conditions. There is, however, not a single eco-evolutionary IBM addressing the three potential adaptive responses simultaneously. Additionally, IBMs implementing adaptive phenotypic plasticity are rare. Most commonly, plasticity was implemented as random noise or reaction norms. Our review further identifies a current lack of models where plasticity is an evolving trait. Future eco-evolutionary models should consider dispersal and plasticity as evolving traits with their associated costs and benefits. Such an integrated approach could help to identify conditions promoting population persistence depending on the life history strategy of organisms and the environment they experience.
Narcissists are assumed to lack the motivation and ability to share and understand the mental states of others. Prior empirical research, however, has yielded inconclusive findings and has differed with respect to the specific aspects of narcissism and socioemotional cognition that have been examined. Here, we propose a differentiated facet approach that can be applied across research traditions and that distinguishes between facets of narcissism (agentic vs. antagonistic) on the one hand, and facets of socioemotional cognition ability (SECA; self-perceived vs. actual) on the other. Using five nonclinical samples in two studies (total N = 602), we investigated the effect of facets of grandiose narcissism on aspects of socioemotional cognition across measures of affective and cognitive empathy, Theory of Mind, and emotional intelligence, while also controlling for general reasoning ability. Across both studies, agentic facets of narcissism were found to be positively related to perceived SECA, whereas antagonistic facets of narcissism were found to be negatively related to perceived SECA. However, both narcissism facets were negatively related to actual SECA. Exploratory condition-based regression analyses further showed that agentic narcissists had a higher directed discrepancy between perceived and actual SECA: They self-enhanced their socio-emotional capacities. Implications of these results for the multifaceted theoretical understanding of the narcissism-SECA link are discussed.
Hintergrund
Lumbale Ruckenschmerzen und ihre Neigung zur Chronifizierung stellen nicht nur in der Allgemeinbevolkerung, sondern auch im Leistungssport ein bedeutendes Gesundheitsproblem dar. Im Gegensatz zu Nichtathleten ist die Erforschung psychosozialer Risikofaktoren sowie von Screeningfragebogen, die moglichst fruhzeitig die Entwicklung chronischer Schmerzen erkennen und vorhersagen konnen, im Leistungssport noch in den Anfangen. Das vorliegende systematische Review gibt einen uberblick uber den Stand der Risikofaktorenforschung in beiden Feldern und untersucht die pradiktive Qualitat verschiedener Screeningfragebogen bei Nichtathleten.
Methodik
Die Literatursuche erfolgte zwischen Marz und Juni 2016 in den Datenbanken MEDLINE, PubMed und PsycINFO mit den Suchbegriffen psychosocial screening, low back pain, sciatica und prognosis, athletes. Eingeschlossen wurden prospektive Studien an Patienten mit lumbalen Ruckenschmerzen mit und ohne Ausstrahlung in das Bein, 18Jahre und mit einem Follow-up von mindestens 3-monatiger Dauer.
Ergebnisse
In das Review zu Screeninginstrumenten wurden 16Studien einbezogen. Alle waren an klinischen Stichproben der Allgemeingesellschaft durchgefuhrt worden. Zu den am haufigsten publizierten Screeningfragebogen gehoren der orebro Musculoskeletal Pain Screening Questionnaire (oMPSQ) mit einer zufriedenstellenden Fruherkennung der Wiederherstellung der Arbeitsfahigkeit sowie das STarT Back Screening Tool (SBT) mit guter Vorhersage schmerzbedingter Beeintrachtigung. Fur die Vorhersage kunftiger Schmerzen eignen sich die Risikoanalyse der Schmerzchronifizierung (RISC-R) und der Heidelberger Kurzfragebogen (HKF).
Schlussfolgerungen
Psychosoziale Risikofaktoren fur chronische Ruckenschmerzen, wie z.B. chronischer Stress, ungunstige Schmerzverarbeitung und depressive Stimmungslagen, werden zunehmend auch im Leistungssport erkannt. Screeninginstrumente, die sich in der Allgemeingesellschaft als hinreichend vorhersagestark erwiesen haben, werden aktuell im MiSpEx-Forschungsverbund auf ihre Eignung uberpruft.
Psychosocial risk factors for chronic back pain in the general population and in competitive sports
(2018)
Lumbar back pain and the high risk of chronic complaints is not only an important health concern in the general population but also in high performance athletes. In contrast to non-athletes, there is a lack of research into psychosocial risk factors in athletes. Moreover, the development of psychosocial screening questionnaires that would be qualified to detect athletes with a high risk of chronicity is in the early stages. The purpose of this review is to give an overview of research into psychosocial risk factors in both populations and to evaluate the performance of screening instruments in non-athletes. The databases MEDLINE, PubMed, and PsycINFO were searched from March to June 2016 using the keywords "psychosocial screening", "low back pain", "sciatica" and "prognosis", "athletes". We included prospective studies conducted in patients with low back pain with and without radiation to the legs, aged ae<yen>18 years and a follow-up of at least 3 months. We identified 16 eligible studies, all of them conducted in samples of non-athletes. Among the most frequently published screening questionnaires, the A-rebro Musculoskeletal Pain Screening Questionnaire (A-MPSQ) demonstrated a sufficient early prediction of return to work and the STarT Back Screening Tool (SBT) revealed acceptable performance predicting pain-related impairment. The prediction of future pain was sufficient with the Risk Analysis of Back Pain Chronification (RISC-BP) and the Heidelberg Short Questionnaire (HKF). Psychosocial risk factors of chronic back pain, such as chronic stress, depressive mood, and maladaptive pain processing are becoming increasingly more recognized in competitive sports. Screening instruments that have been shown to be predictive in the general population are currently being tested for suitability in the German MiSpEx research consortium.
To safeguard the sustainable use of ecosystems and their services, early detection of potentially damaging changes in functional capabilities is needed. To support a proper ecosystem management, the analysis of an ecosystem’s vulnerability provide information on its weaknesses as well as on its capacity to recover after suffering an impact. However, the application of the vulnerability concept to ecosystems is still an emerging topic. After providing background on the vulnerability concept, we summarize existing ecosystem vulnerability research on the basis of a systematic literature review with a special focus on ecosystem type, disciplinary background, and more detailed definition of the ecosystem vulnerability components. Using the Web of ScienceTM Core Collection, we overviewed the literature from 1991 onwards but used the 5 years from 2011 to 2015 for an in-depth analysis, including 129 articles. We found that ecosystem vulnerability analysis has been applied most notably in conservation biology, climate change research, and ecological risk assessments, pinpointing a limited spreading across the environmental sciences. It occurred primarily within marine and freshwater ecosystems. To avoid confusion, we recommend using the unambiguous term ecosystem vulnerability rather than ecological, environmental, population, or community vulnerability. Further, common ground has been identified, on which to define the ecosystem vulnerability components exposure, sensitivity, and adaptive capacity. We propose a framework for ecosystem assessments that coherently connects the concepts of vulnerability, resilience, and adaptability as different ecosystem responses. A short outlook on the possible operationalization of the concept by ecosystem vulnerabilty indices, and a conclusion section complete the review.
Flowers represent a key innovation during plant evolution. Driven by reproductive optimization, evolution of flower morphology has been central in boosting species diversification. In most cases, this has happened through specialized interactions with animal pollinators and subsequent reduction of gene flow between specialized morphs. While radiation has led to an enormous variability in flower forms and sizes, recurrent evolutionary patterns can be observed. Here, we discuss the targets of selection involved in major trends of pollinator-driven flower evolution. We review recent findings on their adaptive values, developmental grounds and genetic bases, in an attempt to better understand the repeated nature of pollinator-driven flower evolution. This analysis highlights how structural innovation can provide flexibility in phenotypic evolution, adaptation and speciation. (C) 2017 Elsevier Ltd. All rights reserved.
Airless bodies are directly exposed to ambient plasma and meteoroid fluxes, making them characteristically different from bodies whose dense atmospheres protect their surfaces from such fluxes. Direct exposure to plasma and meteoroids has important consequences for the formation and evolution of planetary surfaces, including altering chemical makeup and optical properties, generating neutral gas and/or dust exospheres, and leading to the generation of circumplanetary and interplanetary dust grain populations. In the past two decades, there have been many advancements in our understanding of airless bodies and their interaction with various dust populations. In this paper, we describe relevant dust phenomena on the surface and in the vicinity of airless bodies over a broad range of scale sizes from to , with a focus on recent developments in this field.
Numerical knowledge, including number concepts and arithmetic procedures, seems to be a clear-cut case for abstract symbol manipulation. Yet, evidence from perceptual and motor behaviour reveals that natural number knowledge and simple arithmetic also remain closely associated with modal experiences. Following a review of behavioural, animal and neuroscience studies of number processing, we propose a revised understanding of psychological number concepts as grounded in physical constraints, embodied in experience and situated through task-specific intentions. The idea that number concepts occupy a range of positions on the continuum between abstract and modal conceptual knowledge also accounts for systematic heuristics and biases in mental arithmetic, thus inviting psycho-logical approaches to the study of the mathematical mind.
Exercise prescription in patients with different combinations of cardiovascular disease risk factors
(2018)
Whereas exercise training is key in the management of patients with cardiovascular disease (CVD) risk (obesity, diabetes, dyslipidaemia, hypertension), clinicians experience difficulties in how to optimally prescribe exercise in patients with different CVD risk factors. Therefore, a consensus statement for state-of-the-art exercise prescription in patients with combinations of CVD risk factors as integrated into a digital training and decision support system (the EXercise Prescription in Everyday practice & Rehabilitative Training (EXPERT) tool) needed to be established. EXPERT working group members systematically reviewed the literature for meta-analyses, systematic reviews and/or clinical studies addressing exercise prescriptions in specific CVD risk factors and formulated exercise recommendations (exercise training intensity, frequency, volume and type, session and programme duration) and exercise safety precautions, for obesity, arterial hypertension, type 1 and 2 diabetes, and dyslipidaemia. The impact of physical fitness, CVD risk altering medications and adverse events during exercise testing was further taken into account to fine-tune this exercise prescription. An algorithm, supported by the interactive EXPERT tool, was developed by Hasselt University based on these data. Specific exercise recommendations were formulated with the aim to decrease adipose tissue mass, improve glycaemic control and blood lipid profile, and lower blood pressure. The impact of medications to improve CVD risk, adverse events during exercise testing and physical fitness was also taken into account. Simulations were made of how the EXPERT tool provides exercise prescriptions according to the variables provided. In this paper, state-of-the-art exercise prescription to patients with combinations of CVD risk factors is formulated, and it is shown how the EXPERT tool may assist clinicians. This contributes to an appropriately tailored exercise regimen for every CVD risk patient.
Introduction:
We aim to highlight the utility of this model in the analysis of the psycho-behavioral implications of family cancer, presenting the scientific literature that used Leventhal’s model as the theoretical framework of approach.
Material and methods:
A systematic search was performed in six databases (EBSCO, ScienceDirect, PubMed Central, ProQuest, Scopus, and Web of Science) with empirical studies published between 2006 and 2015 in English with regard to the Common Sense Model of Self-Regulation (CSMR) and familial/hereditary cancer. The key words used were: illness representations, common sense model, self regulatory model, familial/hereditary/genetic cancer, genetic cancer counseling. The selection of studies followed the PRISMA-P guidelines (Moher et al., 2009; Shamseer et al., 2015), which suggest a three-stage procedure.
Results:
Individuals create their own cognitive and emotional representation of the disease when their health is threatened, being influenced by the presence of a family history of cancer, causing them to adopt or not a salutogenetic behavior. Disease representations, particularly the cognitive ones, can be predictors of responses to health threats that determine different health behaviors. Age, family history of cancer, and worrying about the disease are factors associated with undergoing screening. No consensus has been reached as to which factors act as predictors of compliance with cancer screening programs.
Conclusions:
This model can generate interventions that are conceptually clear as well as useful in regulating the individuals’ behaviors by reducing the risk of developing the disease and by managing as favorably as possible health and/or disease.
Aldehyde oxidases are molybdenum and flavin dependent enzymes characterized by a very wide substrate specificity and performing diverse reactions that include oxidations (e.g., aldehydes and azaheterocycles), hydrolysis of amide bonds, and reductions (e.g., nitro, S-oxides and N-oxides). Oxidation reactions and amide hydrolysis occur at the molybdenum site while the reductions are proposed to occur at the flavin site. AOX activity affects the metabolism of different drugs and xenobiotics, some of which designed to resist other liver metabolizing enzymes (e.g., cytochrome P450 monooxygenase isoenzymes), raising its importance in drug development. This work consists of a comprehensive overview on aldehyde oxidases, concerning the genetic evolution of AOX, its diversity among the human population, the crystal structures available, the known catalytic reactions and the consequences in pre-clinical pharmacokinetic and pharmacodynamic studies. Analysis of the different animal models generally used for pre-clinical trials and comparison between the human (hAOX1), mouse homologs as well as the related xanthine oxidase (XOR) are extensively considered. The data reviewed also include a systematic analysis of representative classes of molecules that are hAOX1 substrates as well as of typical and well characterized hAOX1 inhibitors. The considerations made on the basis of a structural and functional analysis are correlated with reported kinetic and metabolic data for typical classes of drugs, searching for potential structural determinants that may dictate substrate and/or inhibitor specificities.
The AlpArray seismic network
(2018)
The AlpArray programme is a multinational, European consortium to advance our understanding of orogenesis and its relationship to mantle dynamics, plate reorganizations, surface processes and seismic hazard in the Alps-Apennines-Carpathians-Dinarides orogenic system. The AlpArray Seismic Network has been deployed with contributions from 36 institutions from 11 countries to map physical properties of the lithosphere and asthenosphere in 3D and thus to obtain new, high-resolution geophysical images of structures from the surface down to the base of the mantle transition zone. With over 600 broadband stations operated for 2 years, this seismic experiment is one of the largest simultaneously operated seismological networks in the academic domain, employing hexagonal coverage with station spacing at less than 52 km. This dense and regularly spaced experiment is made possible by the coordinated coeval deployment of temporary stations from numerous national pools, including ocean-bottom seismometers, which were funded by different national agencies. They combine with permanent networks, which also required the cooperation of many different operators. Together these stations ultimately fill coverage gaps. Following a short overview of previous large-scale seismological experiments in the Alpine region, we here present the goals, construction, deployment, characteristics and data management of the AlpArray Seismic Network, which will provide data that is expected to be unprecedented in quality to image the complex Alpine mountains at depth.
Die Operationen des italienischen Heeres an der Ostfront bleiben auch 70 Jahre nach dem Ende des Zweiten Weltkrieges ein weitgehend unerschlossenes Forschungsfeld. So sind sowohl der Einsatz der 62 000 Mann des Corpo di Spedizione Italiano in Russia (CSIR) seit August 1941 als auch die nachfolgenden Operationen der auf 229 000 Soldaten aufgestockten Armata Italiana in Russia (ARMIR, oder auch 8. Armee) zur Sicherung des Don während der Schlacht um Stalingrad recht unbekannt geblieben. Eine wegweisende Studie von Thomas Schlemmer konnte vor zehn Jahren erste Impulse geben, die allerdings von der Forschung nicht vollends aufgenommen oder weiterentwickelt wurden. So dominiert neben den offiziellen Werken des italienischen Militärs vor allem die Memoirenliteratur weiterhin das Forschungsfeld und die Erzählmuster. Nun hat Maria Teresa Giusti im renommierten Il Mulino Verlag eine Gesamtdarstellung vorgelegt.
Dass Giusti Primärquellen aus italienischen und russischen Archiven verwendet, ist vor dem Hintergrund der italienischen Wissenschaftspraxis und des schwierigen Archivzugangs besonders anerkennenswert. Ihre Archivarbeit in Moskau – und die umfassende Heranziehung der russischen Sekundärliteratur – sind sicherlich ein Alleinstellungsmerkmal. Zudem hat Giusti bereits viel beachtete Werke zu den italienischen Kriegsgefangenen in sowjetischer Hand und der Besatzungszeit auf dem Balkan vorgelegt.
Giustis Buch erhebt den Anspruch, eine Gesamtdarstellung des »Krieges im Osten« zu bieten. Beginn und Ende des Werkes erfüllen dies jedoch nicht umfassend: Die Einleitung enthält keinen Abriss des Forschungsstandes und wirkt oft zerfahren. Gut ein Drittel der gesamten Arbeit wird dazu verwendet, die Vorgeschichte des Ostkrieges zu erklären – ohne Berücksichtigung der hinlänglich bekannten Standardwerke oder Debatten. Die »Conclusio« ist eher ein Epilog, als dass sie eine Zusammenfassung der Erkenntnisse bietet. Auch die übrigen Kapitel sind teilweise kleinteilig und sorgen mitunter für Irrungen und Wirrungen: So wird nach der Beschreibung des CSIR-Aufmarsches und der ersten Operationen bis September 1941 ein ausschweifender Abschnitt (20 Seiten) über die Belagerung Leningrads, die gescheiterte Offensive auf Moskau und die US-Hilfen nach dem Lend-Lease Act eingeschoben. Hier überzeugt Giusti durch ihre weitreichenden Kenntnisse der russischen Perspektive. Doch ein Problem des Buches bleibt: Es wird selten deutlich, was das eigentliche Kernthema oder die Kernthesen sind. Die italienische Armee an der Ostfront? Die deutsche Idee des Lebensraums? Stalins Herrschaft in der Sowjetunion? Da ein Spagat zwischen allen Themenfeldern nicht gelingt, kann Giustis Darstellung nicht in allen Punkten überzeugen.
Giusti vergleicht ausführlich das italienische und deutsche Okkupationsmodell: Während Mussolinis Konzept des spazio vitale eine Kooptierung der lokalen Bevölkerung, »humane« Behandlung durch den »Zivilisierenden« und daher keine »barbarische« Bestrafungen vorgesehen habe, wird Hitlers Idee des Lebensraums als Gegenentwurf skizziert, der zu den Massenverbrechen und einer fundamental unterschiedlichen Haltung der Wehrmacht in den besetzten Gebieten führte. Eine Differenzierung der Wehrmachtverbrechen sowie anderer deutscher Behörden unterbleibt. Giusti führt das Verhalten der Wehrmachtsoldaten – auf Omer Bartov Bezug nehmend – auf deren Beeinflussung durch die NS-Ideologie und ‑propaganda zurück und stellt dem den wenig politischen und nicht »fanatisierten« Einsatz der Italiener gegenüber. Dieser Teil des Buches wird wohl besonders und speziell in Deutschland zu einigen Debatten führen. Die Heranziehung der neueren italienischen Forschungsliteratur zur Besatzung am Don stützt allerdings Giustis Thesen einer weniger brutal ausgeprägten italienischen Besatzungsherrschaft.
Das Verhältnis zum deutschen Bündnispartner wird entlang der gängigen Erklärungsmustern dargestellt. Italienische Quellen aus der Nachkriegszeit, die auf mangelnde Unterstützung der deutschen Stellen am Don hinweisen, werden jedoch zu unkritisch übernommen und dies, ohne die Gesamtlage der Ostfront im Winter 1942/43 einzubeziehen. Bei der Analyse von Operationen und den beteiligten Streitkräften fehlt oft die Tiefe. Giusti erklärt kurzerhand, dass es in der italienischen und sowjetischen Armee kein eigenständiges Handeln gegeben habe, da niemand sich traute, Mussolini bzw. Stalin zu widersprechen. Das Durcheinanderwerfen der taktischen, operativen und politischen Ebenen wird dabei ebenso in Kauf genommen, wie das Fehlen einer stringenten Beweisführung für diese Thesen.
Neben kleineren Mängeln in militärhistorischen Fragen oder im Umgang mit den Verbündeten (Günther Blumentritt wird ad hoc geadelt, während Friedrich Paulus schon während des Vormarschs an die Wolga als Feldmarschall auftritt) ist zudem das Fehlen von Kartenmaterial als Manko anzusehen. Nur eine sehr grob gefasste Übersicht stellt den Frontverlauf im Winter 1942/43 dar, ansonsten verliert sich die Leserin oder der Leser zwangsläufig in der ukrainischen bzw. russischen Provinz. Zudem erschweren lange Blockzitate den Lesefluss. Häufig führt Giusti Memoiren und Feldpostbriefe als Belege an, ohne quellenkritisch auf mögliche Probleme bei der Auswertung dieser Selbstzeugnisse hinzuweisen.
Giustis Werk zeigt, wie viel Forschung zur Geschichte Italiens im Zweiten Weltkrieg noch geleistet werden muss und wie wichtig hierbei der internationale Vergleich und Austausch ist. Ihr Buch stellt einerseits eine wichtige Ergänzung der Forschung dar, wirft aber andererseits viele Fragen für weitere Studien auf: Wie stand es um die Kampfkraft der italienischen Armee jenseits von Klischee und anekdotischer Evidenz? Worin und warum unterschied sich die deutsche und italienische Besatzungspolitik? Wie lässt sich die Ostfront als italienischer Erinnerungsort klassifizieren?
The book by Božena Bednaříková, Slovo a jeho konverze (‘BSJK’), was originally published in 2009. However, in our view, there has not yet been given a due consideration and certainly not recognition as a genuine new territory of word formation. This is the reason to write a short review in order to give this book the consideration it has by large and far deserved. For in this book, two theoretically interesting working hypotheses are represented and covered by numerous examples of the Czech contemporary language: (i) conversion is the central process (not derivation), and (ii) conversion belongs to morphology and not (just) to word formation.
The book is divided into 9 sections. The section 1 (p. 13–14) gives the road map of the book, in section 2 (p. 15–42), the central concern about the position of word as a central unit of morphology (form formation) is established. In this chapter, the traditional views of Czech descriptive and Academic grammars but also manuals and handbooks or teacher’s books for high schools are reviewed. In most of them, word formation is considered being a part of lexicology, and not an integral part of morphology or better form formation. The review serves not only the improvement towards a unifying grammatical terminology in academic circles (university and academy of science) but it should also improve the quality of teaching at elementary and high schools (cf. 2.6., p. 31–42: Školský exkurz). Bednaříková is famous for her leading role as missing link between the Academia and the consumers of grammars. In chapter 3, entitled Návrat slova ‘The return of the word’ (into the Morphology, p. 43–54), arguments in favor of a morphological approach are raised. In this important methodological chapter, the main reasons are given why the word must be a central part of the form formation (morphology/grammar) and not of the lexicology. In addition, key terms such as stem, root and affix are subject to revision. The chapter is very brief, but very precise in its reasoning and arguments, in which the formal teaching is assigned a central supporting role in the context of conversion and transposition. In chapter 4 Slovo jako slovní druh (‘The word as a pars orationis’, p. 55–70), the syntactic function of transposition of one pars orationis to another with the means of conversion is considered. In Chapter 5, the central role of morphology for word formation is analyzed taking as starting point Mel’čuks theory which is understood as the analysis of morphological processes (cf. Mel’čuk, I. 2000. Morphological processes. In G. Booji, Ch. Lehmann, J. Mugdan, & S. Skopeteas (eds.), Morphologie/Morphology. Vol. 1, 523–535. Berlin & New York). The innovative part of the book are without any doubt the chapters 6–9, in which the internal structure of the word is introduced (chapter 6, 79–122), furthermore the part of speech transfer (or PS Transfer) including the conversion (Chapter 7, 123–149), once more the transposition understood as the shift from one part of speech to the other and concentrating on nouns, verbs and adjectives (Chapter 8, 150–201), and, finally, transflexion, “transflexe” (chapter 9, 203–219), which belongs rather to the domain of derivation than to a new type of word formation, and which does not include the transposition from one part of speech to another but rather the transition from one declension class to another. However, it is to be criticized that in some chapters, certain systematics are missing (this is expressed for example in the repetition of the same phenomenon in several places), and the illustrations in the form of derivation trees or the abbreviations are not always transparent and explicitly defined. It took a very long time until I received information about the abbreviation “S”.
I would now like to give a short statement concerning the innovative potential and the contribution of the book itself as compared to the western standard on the same topic. At the beginning of the monograph, the author raises the central concerns of her two hypotheses. In her study, she is concerned with the bases of morphemic analysis of word formation and with the function of the syntagma. In view of methodology, two central acts of actualization are, following Mathesius’ terminology, under review: first, the category called “pojmenovávací”, and second, the category called “usouvztažňovací” (cf. also Mathesius, V. 1982. Jazyk, kultura a slovesnost; Daneš, F. 1991.Mathesiova koncepce funkční gramatiky v kontextu dnešní jazykovědy. In SaS 52. 161–174 and Panevová, J. 2010. Kategorie pojmenovávací a usouvztažňovací [Jak František Daneš rozvíjí Viléma Mathesia]. In S. Čmejrková & J. Hoffmannová ad. [eds.], Užívání a prožívání jazyka, 21–26.). Her major concern is thus to establish a missing link between an analysis of word formation and form formation (morphology). Her morphemic analysis of word formation processes wants to “combat traditional school views of word formation as a (mechanical) connection of the root, prefix, and suffix”. Doing so, she analyzes in the book the relationship between transfer, transposition (as change of partes orationis) and conversion (as the operation process serving transposition). In the last chapter 8, BSJK re-introduces and refines the term transflection (BSJK 2009,13).
This book is important for its consistent satisfactory treatment of the term conversion as a morphological process in the Czech tradition; still we cannot confirm that in European context, this topic would be “seriously under-researched” (cited from the introduction, Chapter 1, p. 13). The contrary is true, in context of English word formation besides the most influential work by Marchand (Marchand, H. 1996. The categories and types of present-day English word-formation: A synchronic diachronic approach. 2nd ed. München), conversion as the most productive process of word formation has become perhaps the most researched object recently: to mention just a few influential monographs: Martsa, S. 2013. Conversion in English: A Cognitive Semantic Approach. Cambridge; Vogel, P. M. 1996. Wortarten und Wortartenwechsel. Berlin & New York.
The word formation called conversion originally comes from analytic languages such as English and French. Especially English is a language in which the derivation of a noun from a verb and vice versa causes a considerable large amount of homonymous forms in the dictionary and of course, this is not just a problem of morphology but especially a problem of any theoretical approach to language acquisition, cognitive semantics or even generative morphosyntax. Thus, in his seminal book, Language Instinct (1995), Steven Pinker argues persuasively that prescriptive grammar rules disallowing, among other things, the sentence-final use of prepositions, the splitting of infinitives and the conversion of nouns to verbs are both useless and nonsensical (371–379). As regards the conversion of nouns to verbs, he says: “[i]n fact the easy conversion of nouns to verbs has been part of English grammar for centuries; it is one of the processes that make English English” (ibidem: 379). To illustrate the easiness characterizing this type of conversion, he lists verbs converted from nouns designating human body parts, some of which are reproduced in (1):
(1) head a committee, scalp a missionary, eye a babe, nose around the office, mouth the lyrics, tongue each note on the flute, neck in the back seat, back the candidate, arm the militia, shoulder the burden, elbow your way in, finger the culprit, knuckle under, thumb a ride, belly up to the bar, stomach someone’s complaints, knee the goalie, leg it across the town, foot the bill, toe the line (cf. Pinker, S. 1995. The Language Instinct. New York, 379–380 and Pinker, S. 1996. Language learnability and language development. Cambridge MA)
Pinker estimates that approximately a fifth of English verbs originate from nouns, which, as documented extensively in Clark & Clark (Clark, E. V. & H. H. Clark. 1979. When nouns surface as verbs. In Language 55. 767–811), may also have to do with the fact that new or innovative verbs in English arise predominantly from conversion of nouns to verbs.
Without questioning the dominance of noun to verb conversion, I shall claim in this review that it is not only the easy conversion of verbs from nouns, but, more broadly, conversion as a word-formation process that makes English English. Consider, for instance, (2) below demonstrating that the easiness of forming conversion verbs equally characterizes, though in a lesser degree, the conversion of nouns from verbs. The expressions given in (2) are modelled on Pinker’s above examples by the seminal work of Sándor Martsa (2013. Conversion in English: A Cognitive Semantic Approach. Cambridge), and they contain nouns converted from verbs designating actions functionally related to different parts of the human body.
(2) have your say, give a shout, let out a shriek / a cry, give a talk, take a look at the notes, keep a close watch, down the whisky with a swallow, have a chew on it, have a smell of this cheese, with a smile, the touch of her fingers, Hey! Nice catch! go for a run, it’s worth a go, go for a walk
Thus, the major difference between the term konverze as introduced and defended in BSJK (2009, 149) on one hand, and the English type of conversion mostly called “Zero-Derivation” by a zero morpheme (as Marchand 1969 op. cit., has called it) is to be found inside of the two quite different systems of word formation.
Czech very rarely allows for pure zero derivation such as demonstrated in the English examples (1)-(2).
Despite this major difference, even Czech language being still a highly inflectional language with rich case, number and declension system and agreement, nevertheless more and more allows for similar word formations typical for English with a true zero affixation, e. g. tunnel > to tunnel : Cz tunel > tunelovat and this process is an integral part of the grammar because it includes even the category of verbal aspect deriving also the perfective forms and negated verbs such as nevytunelovalo peníze,
ve snaze “politicky korektně” uctít Havlovu památku jednotliví ministři české vlády přislíbili, že přestanou tento stát vykrádat a tunelovat, tedy alespoň do začátku příštího roku; Nové vedení Obce spisovatelů a jeho sekretariát nevytunelovalo peníze Obce spisovatelů, vždyť nebylo ani co tunelovat, naopak zachránilo tuto organizaci před téměř nezvratným koncem (ČNK. Last accessed July 10, 2018).
Thus conversion is becoming more and more an important process of word and form formation in the system of Czech word formation and morphology.
One critical observation remains to be mentioned: The book is solid but in a certain sense restricted to just functional approaches not considering or even including the important contribution of alternative approaches in formal linguistics. Thus, mainstream generative syntax, based on the theory of government and binding or minimalism (introduced by Noam Chomsky in 1981 and 1995), are not reviewed in this book even though there are many allusions including the important role of syntax for word formation (this is an important demand on any theory of word formation, cf. also Dokulil, M. 1962. K vzájemnému poměru slovotvorby a skladby. In Acta Universitatis Carolinae: SLAVICA PRAGENSIA IV, 369–375. UK, Praha).
Most of the recent work devoted to a theoretical approach of minimalism considers conversion as a “syntactic decomposition” based on root semantics (cf. e. g. Borer, H. 2005. In name only: Structuring sense Vol. I. & The normal course of events: Structuring sense Vol. II. Oxford; Harley, H. & R. Noyer. 1999. State-of-the article: Distributed Morphology. In GLOT 4. 3–9; Halle, M. & A. Marantz. 1993. Distributed morphology and the pieces of inflection. In Keyser, S. J. & K. Hale (eds.), The view from Building 20, 111–176. Cambridge.). A recent development in minimalism is the concept of roots and categorial features (cf. Panagiotidis, Ph. 2014. Categorial Features. A Generative Theory of Word Class Categories. Cambridge.). This theory differentiates between so-called true “denominal verbs tape-type verbs” as opposed to those verbs which are “directly derived from a root hammer-type”. The structural differences between them are argued by Panagiotidis (2014: 63) “to account for the idiosyncratic meaning of the latter, as opposed to the predictable and systematic meaning of the former”. The two types are demonstrated under (3) vs. (4)
(3) nP vP
/ \ / \
N HAMMER v xP
/ \
HAMMER x
(Panagiotidis op. cit., 2014: 63)
In (3) to the left, the nominalizer head n takes a root complement, nominalizing it syntactically. In the tree to the right, the root h a m m e r is a manner adjunct to an xP (schematically rendered) inside the vP. On the other hand, verbs like tape behave differently. They seem to be truly denominal, formed by converting a noun into a verb, by recategorizing the noun and not by categorizing a root. By hypothesis, the verbalizing head takes as its complement a structure that already contains a noun – that is, an nP in which the root tape has already been nominalized:
(4) nP vP
/ \ / \
N TAPE v xP
/ \
np. X
/ \
n TAPE
(Panagiotidis 2014:63)
As opposed to this approach, the present monograph uses the term “transpozice” (‘transposition’) as the change of parts of speech of different classes by the means of konverze (‘conversion’) (chapter 8, 151–201). We will just mention one typical class or type of such conversions as given under (5) and (6):
(5) kapř
/ \
Kapř í
(BSJK,156)
(6) výlov [vylovit]
/ \
vý [vy] lov [lovit]
(BSJK, 180)
In summary, I would see the great merit of the publication especially in a new view on ancient phenomena. Additionally, the work also excels in a thorough multi-level analysis of conversion, transposition and transflexion, including consideration of morphonological alternations and differences of semantic interpretation by adding or removing a specific onomasiological feature (according to the onomasiological word formation theory of Dokulil, M. 1962. Tvoření slov v češtině. Teorie odvozování slov. Praha.).
Above all, I value the book because of its consistent insistence on the role of shaping for conversion as a part of morphology (form formation). I also think that conversion will play an increasingly important role in the further development of the Czech language, both for system external reasons, as a language contact phenomenon for English, but also for system inherent reasons, triggered and flanked by the tendency towards analytism and simplification, and finally the gradual reduction of the complex inflectional system of nouns and verbs.
For the theoretical linguist, this book may not be a substitute for word-formation theories such as Marchand, op. cit. (1969) or Dokulil, op. cit. (1962, 1968); but it is a very stimulating and original study in which a more thorough reading could lead to a differentiated view than that given here, showing the differences between a true zero-derivative language such as English based on a more elaborated morpho-syntactic generative theory of root semantics by Panagiotidis (2014) in which the term conversion is very different from that presented in Bednaříkovás book (see Examples 1 and 2), and a derivational language such as Czech with additional affixes and other word-forming means more clearly.
The author is to be recommended for bridging the gap with traditional (and, in my view, not negligible) theories and newer views. The work must necessarily have place in every slavist’s and bohemist’s book shelf.
Cardiogenesis is a complex developmental process involving multiple overlapping stages of cell fate specification, proliferation, differentiation, and morphogenesis. Precise spatiotemporal coordination between the different cardiogenic processes is ensured by intercellular signalling crosstalk and tissue-tissue interactions. Notch is an intercellular signalling pathway crucial for cell fate decisions during multicellular organismal development and is aptly positioned to coordinate the complex signalling crosstalk required for progressive cell lineage restriction during cardiogenesis. In this Review, we describe the role of Notch signalling and the crosstalk with other signalling pathways during the differentiation and patterning of the different cardiac tissues and in cardiac valve and ventricular chamber development. We examine how perturbation of Notch signalling activity is linked to congenital heart diseases affecting the neonate and adult, and discuss studies that shed light on the role of Notch signalling in heart regeneration and repair after injury.
The relevance for in vitro three-dimensional (3D) tissue culture of skin has been present for almost a century. From using skin biopsies in organ culture, to vascularized organotypic full-thickness reconstructed human skin equivalents, in vitro tissue regeneration of 3D skin has reached a golden era. However, the reconstruction of 3D skin still has room to grow and develop. The need for reproducible methodology, physiological structures and tissue architecture, and perfusable vasculature are only recently becoming a reality, though the addition of more complex structures such as glands and tactile corpuscles require advanced technologies. In this review, we will discuss the current methodology for biofabrication of 3D skin models and highlight the advantages and disadvantages of the existing systems as well as emphasize how new techniques can aid in the production of a truly physiologically relevant skin construct for preclinical innovation.
Silicon (Si) is considered as a quasiessential element for higher plants as its uptake increases plant growth and resistance against abiotic as well as biotic stresses. Foliar application of fertilizers generally is assumed to be a comparably environment-friendly form of fertilization because only small quantities are needed. The interest in foliar fertilization and the use of Si as a fertilizer in general increased significantly within the last decades, but there are only few publications dealing with the foliar application of Si at all. In the present review, the effects of Si foliar fertilization, including nano-Si fertilizers, on the three most important crops on a global scale, that is, maize, rice, and wheat, are summarized. Additionally, different pathways (i.e., cuticular pathways, stomata, and trichomes) of foliar uptake and functioning of Si foliar fertilizers against biotic (i.e., fungal diseases and harmful insects), as well as abiotic (i.e., water stress, macronutrient imbalance, and heavy metal toxicity) stressors are discussed. Future research should especially focus on (1) the gathering of empirical data from field and greenhouse experiments, (2) the intensification of co-operations between practitioners and scientists, (3) interdisciplinary research, and (4) the analysis of results from multiple studies (meta-analysis, big data) to fully understand effects, uptake, and functioning of Si foliar fertilizers and to evaluate their potential in modern sustainable agriculture concepts.
Like almost all fields of science, hydrology has benefited to a large extent from the tremendous improvements in scientific instruments that are able to collect long-time data series and an increase in available computational power and storage capabilities over the last decades. Many model applications and statistical analyses (e.g., extreme value analysis) are based on these time series. Consequently, the quality and the completeness of these time series are essential. Preprocessing of raw data sets by filling data gaps is thus a necessary procedure. Several interpolation techniques with different complexity are available ranging from rather simple to extremely challenging approaches. In this paper, various imputation methods available to the hydrological researchers are reviewed with regard to their suitability for filling gaps in the context of solving hydrological questions. The methodological approaches include arithmetic mean imputation, principal component analysis, regression-based methods and multiple imputation methods. In particular, autoregressive conditional heteroscedasticity (ARCH) models which originate from finance and econometrics will be discussed regarding their applicability to data series characterized by non-constant volatility and heteroscedasticity in hydrological contexts. The review shows that methodological advances driven by other fields of research bear relevance for a more intensive use of these methods in hydrology. Up to now, the hydrological community has paid little attention to the imputation ability of time series models in general and ARCH models in particular.
This article presents some insights into the German developments of studying Judaism and the Jewish tradition and relates them to the ongoing development of the subject at universities in the Nordic countries in general and Norway in particular. It also aims to present some conclusions concerning why it might be interesting for Norwegian society to intensify the study of Judaism at its universities.
In order to replace bio-macromolecules by stable synthetic materials in separation techniques and bioanalysis biomimetic receptors and catalysts have been developed: Functional monomers are polymerized together with the target analyte and after template removal cavities are formed in the "molecularly imprinted polymer" (MIP) which resemble the active sites of antibodies and enzymes. Starting almost 80 years ago, around 1,100 papers on MIPs were published in 2016. Electropolymerization allows to deposit MIPs directly on voltammetric electrodes or chips for quartz crystal microbalance (QCM) and surface plasmon resonance (SPR). For the readout of MIPs for drugs amperometry, differential pulse voltammetry (DPV) and impedance spectroscopy (EIS) offer higher sensitivity as compared with QCM or SPR. Application of simple electrochemical devices allows both the reproducible preparation of MIP sensors, but also the sensitive signal generation. Electrochemical MIP-sensors for the whole arsenal of drugs, e.g. the most frequently used analgesics, antibiotics and anticancer drugs have been presented in literature and tested under laboratory conditions. These biomimetic sensors typically have measuring ranges covering the lower nano-up to millimolar concentration range and they are stable under extreme pH and in organic solvents like nonaqueous extracts.
Work has become more precarious in recent years. Although this claim is more or less uncontested among social scientists, there are a still many questions that have not yet been conclusively answered. What exactly constitutes precariousness? How should it be operationalized and measured? How does the character of precarious employment vary across organizations, occupations, demographic groups, and countries?
The edited volume by Arne Kalleberg and Steven Vallas seeks to provide answers to these and related questions. Sociologists from around the world employed different methodologies in a broad range of economic sectors and countries to identify the origins, manifestations, and consequences of precarious work. The different contributions not only illustrate the great heterogeneity that exists within precarious employment but also point to some central features of precarious work independent of the geographical context in which it occurs. Moreover, they highlight some challenges for the study of precarious work.
First, drawing on their earlier work, Kalleberg and Vallas conceptualize precarious employment as work that is characterized by uncertainty and insecurity with regard to pay and the stability of the work arrangement; workers in precarious jobs only have limited access to social benefits and statutory protections and bear the entrepreneurial risk of the employment relationship. This broad definition not only captures various forms of nonstandard employment, such as temporary employment, part-time work, or one-person businesses, but also covers informal workers or workers who are at risk of losing their jobs. Nonetheless, this definition does not seem to be broad enough or specific enough to fit the needs of all types of research and to appropriately capture the multifaceted nature of precarious work. Kiersztyn, for example, shows the necessity to distinguish between objective and subjective insecurities when measuring precarious work. Likewise, Rogan et al. point out that the concept of “precarious employment” has little resonance in the developing world, where most of the workforce is at or near poverty and informal work is the default employment type.
Second, the book repeatedly illustrates that the increase in precarious work can be attributed to the rise of neoliberal doctrines and practices, the deinstitutionalization of organized workers, and the dismantling of the welfare state. This applies not only to the United States, where market logics have often been equated with economic freedom, but also to countries like Germany with its corporatist tradition and a strong welfare state (Brady and Biegert) as well as to emerging economies like India (Sapkal and Sundar). In the opening chapter, Pulignano, moreover, convincingly argues that the institutional determinants of precariousness should not only be sought at the national level but that the supranational context plays a major role when it comes to explain precarity.
Third, by focusing on different aspects of precariousness and employment, the book shows the need for differentiation when studying precarious work. This is nicely illustrated by the following three chapters, which draw different conclusions on the gendered nature of precarious employment. Wallace and Kwak study the rise of “bad jobs” in U.S. metropolitan areas and show that men’s work became more precarious during the Great Financial Crisis. By contrast, Banch and Hanley, who have investigated the prevalence of different forms of nonstandard work since the 1980s in the United States, show that the risk of working in precarious jobs has declined over time for men. Likewise, Witteveen shows that the employment trajectories of young men are less precarious than those of young women in the United States. These seemingly contradictory claims stem from the fact that the authors focused on different aspects of precariousness, used different methodologies and datasets, and took on slightly different populations and time frames. The work on precarious work is hence not yet done.
Fourth, precarious work is certainly no longer a characteristic of those with low levels of education but has increasingly become common among professional and technical workers as well. It might come in disguise and is oftentimes perceived as an opportunity, a means for career advancement, and a personal choice. These disguises and perceptions are evident in chapters by Zukin and Papadantonakis on the unpaid work performed by programmers in hackathons, the chapter by Rao on young professionals in international organizations, and to some degree also the chapter by Williams on professional female workers in the oil and gas industry.
These insights (and more that are not mentioned here) make the book relevant and interesting to read. A summary chapter to synthesize the diverse findings and potentially also outline some of the methodological challenges in the study of precarious work would have had been a nice close of the book. Furthermore, such a summation would have been the place to speculate about the consequences of recent changes in the world of work, such as the rise of the gig economy and cloud or crowd work, which add new forms of precarity to the ones that we have known thus far.
Although it has primarily been written for an academic audience, the book is a highly commendable and enjoyable read for both social scientists and practitioners such as labor activists, human resources managers, and policy makers. Moreover, the book is certainly a valuable teaching resource suitable for graduate and master’s seminars in sociology due to its broad coverage of various aspects of precariousness, geographical regions, and methodological approaches.