Refine
Year of publication
- 2024 (143)
- 2023 (1169)
- 2022 (2071)
- 2021 (2312)
- 2020 (2795)
- 2019 (2583)
- 2018 (2813)
- 2017 (2519)
- 2016 (2352)
- 2015 (2166)
- 2014 (1884)
- 2013 (2103)
- 2012 (1993)
- 2011 (2047)
- 2010 (1445)
- 2009 (1835)
- 2008 (1363)
- 2007 (1396)
- 2006 (1804)
- 2005 (1956)
- 2004 (2021)
- 2003 (1553)
- 2002 (1354)
- 2001 (1425)
- 2000 (1686)
- 1999 (1852)
- 1998 (1690)
- 1997 (1541)
- 1996 (1557)
- 1995 (1473)
- 1994 (1031)
- 1993 (405)
- 1992 (255)
- 1991 (169)
- 1990 (16)
- 1989 (28)
- 1988 (22)
- 1987 (23)
- 1986 (16)
- 1985 (12)
- 1984 (15)
- 1983 (31)
- 1982 (10)
- 1981 (9)
- 1980 (10)
- 1979 (15)
- 1978 (9)
- 1977 (12)
- 1976 (7)
- 1975 (3)
- 1974 (2)
- 1973 (2)
- 1972 (2)
- 1971 (2)
- 1970 (1)
- 1958 (1)
Document Type
- Article (35303)
- Doctoral Thesis (6469)
- Monograph/Edited Volume (5521)
- Postprint (3296)
- Review (2285)
- Part of a Book (1012)
- Other (879)
- Preprint (567)
- Conference Proceeding (532)
- Part of Periodical (451)
Language
- English (30202)
- German (25854)
- Spanish (362)
- French (329)
- Italian (114)
- Russian (112)
- Multiple languages (65)
- Hebrew (36)
- Portuguese (25)
- Polish (24)
Keywords
- Germany (200)
- climate change (174)
- Deutschland (141)
- European Union (78)
- machine learning (78)
- Sprachtherapie (77)
- diffusion (74)
- Patholinguistik (73)
- morphology (73)
- patholinguistics (73)
Institute
- Institut für Biochemie und Biologie (5378)
- Institut für Physik und Astronomie (5343)
- Institut für Geowissenschaften (3562)
- Institut für Chemie (3452)
- Wirtschaftswissenschaften (2642)
- Historisches Institut (2487)
- Department Psychologie (2332)
- Institut für Mathematik (2132)
- Institut für Romanistik (2106)
- Sozialwissenschaften (1883)
Gilles Blanchards Vortrag gewährt Einblicke in seine Arbeiten zur Entwicklung und Analyse statistischer Eigenschaften von Lernalgorithmen. In vielen modernen Anwendungen, beispielsweise bei der Schrifterkennung oder dem Spam- Filtering, kann ein Computerprogramm auf der Basis vorgegebener Beispiele automatisch lernen, relevante Vorhersagen für weitere Fälle zu treffen. Mit der mathematischen Analyse der Eigenschaften solcher Methoden beschäftigt sich die Lerntheorie, die mit der Statistik eng zusammenhängt. Dabei spielt der Begriff der Komplexität der erlernten Vorhersageregel eine wichtige Rolle. Ist die Regel zu einfach, wird sie wichtige Einzelheiten ignorieren. Ist sie zu komplex, wird sie die vorgegebenen Beispiele "auswendig" lernen und keine Verallgemeinerungskraft haben. Blanchard wird erläutern, wie Mathematische Werkzeuge dabei helfen, den richtigen Kompromiss zwischen diesen beiden Extremen zu finden.
Since Harris’ parser in the late 50s, multiword units have been progressively integrated in parsers. Nevertheless, in the most part, they are still restricted to compound words, that are more stable and less numerous. Actually, language is full of semi-fixed expressions that also form basic semantic units: semi-fixed adverbial expressions (e.g. time), collocations. Like compounds, the identification of these structures limits the combinatorial complexity induced by lexical ambiguity. In this paper, we detail an experiment that largely integrates these notions in a finite-state procedure of segmentation into super-chunks, preliminary to a parser.We show that the chunker, developped for French, reaches 92.9% precision and 98.7% recall. Moreover, multiword units realize 36.6% of the attachments within nominal and prepositional phrases.
We investigate charge transport in a high-electron mobility polymer, poly(N, N-bis 2-octyldodecyl-naphthalene-1,4,5,8-bis dicarboximide-2,6-diyl-alt-5,5-2,2-bithiophene) [P(NDI2OD-T2), Polyera ActivInk (TM) N2200]. Time-of-flight measurements reveal electron mobilities approaching those measured in field-effect transistors, the highest ever recorded in a conjugated polymer using this technique. The modest temperature dependence and weak dispersion of the transients indicate low energetic disorder in this material. Steady-state electron-only current measurements reveal a barrier to injection of about 300 meV. We propose that this barrier is located within the P(NDI2OD-T2) film and arises from molecular orientation effects.
We simulate organic bulk heterojunction solar cells. The effects of energetic disorder are incorporated through a Gaussian or exponential model of density of states. Analytical models of open-circuit voltage (V(OC)) are derived from the splitting of quasi-Fermi potentials. Their predictions are backed up by more complex numerical device simulations including effects such as carrier-density-dependent charge-carrier mobilities. It is predicted that the V(OC) depends on: (1) the donor-acceptor energy gap; (2) charge-carrier recombination rates; (3) illumination intensity; (4) the contact work functions (if not in the pinning regime); and (5) the amount of energetic disorder. A large degree of energetic disorder, or a high density of traps, is found to cause significant reductions in V(OC). This can explain why V(OC) is often less than expected in real devices. Energetic disorder also explains the nonideal temperature and intensity dependence of V(OC) and the superbimolecular recombination rates observed in many real bulk heterojunction solar cells.
We have used space-charge limited current measurements to study the mobility of holes and electrons in two fluorene-based copolymers for temperatures from 100 to 300 K. Interpreting the results using the standard analytical model produced an Arrhenius-type temperature dependence for a limited temperature range only and mobility was found to be apparently dependent on the thickness of the polymer film. To improve on this, we have interpreted our data using a numerical model that takes into account the effects of the carrier concentration and energetic disorder on transport. This accounted for the thickness dependence and gave a more consistent temperature dependence across the full range of temperatures, giving support to the extended Gaussian disorder model for transport in disordered polymers. Furthermore, we find that the same model adequately describes both electron and hole transport without the need to explicitly include a distribution of electron traps. Room-temperature mobilities were found to be in the region of 4 x 10(-8) and 2 x 10(- 8) cm(2) V-1 s(-1) in the limit of zero field and zero carrier density with disorders of 110+/-10 and 100+/-10 meV for polymers poly{9,9-dioctylfluorene-co-bis[N,N'-(4-butylphenyl)]bis(N, N'-phenyl-1,4-phenylene)diamine} and poly(9,9-dioctylfluorene-co-benzothiadiazole), respectively.
Relating to students
(2012)
1. The Assignment 'Devotion to Religion and acitive Citizenship' 2. The Assignment 'How are religious spread across Europe' 3. The Assignment 'Is football as important as religion?' 4. The Assignment 'Why be religious?' 5. The Assignment 'Lucky charms' 6. The Assignment 'No Creo en el Jamas' (Life after death) 7. The Assignment 'Religion and its influence on politics ans policies' 8. The Assignment 'Secularisation in Europe' 9. The Assignment 'The meaning of religious places' 10. The Assignment 'Unity in diversity' 11. Which conceptions did you find?
Phase models are a powerful method to quantify the coupled dynamics of nonlinear oscillators from measured data. We use two phase modeling methods to quantify the dynamics of pairs of coupled electrochemical oscillators, based on the phases of the two oscillators independently and the phase difference, respectively. We discuss the benefits of the two-dimensional approach relative to the one-dimensional approach using phase difference. We quantify the dependence of the coupling functions on the coupling magnitude and coupling time delay. We show differences in synchronization predictions of the two models using a toy model. We show that the two-dimensional approach reveals behavior not detected by the one-dimensional model in a driven experimental oscillator. This approach is broadly applicable to quantify interactions between nonlinear oscillators, especially where intrinsic oscillator sensitivity and coupling evolve with time.
Multi-column dependencies in relational databases come associated with two different computational tasks. The detection problem is to decide whether a dependency of a certain type and size holds in a given database, the discovery problem asks to enumerate all valid dependencies of that type. We settle the complexity of both of these problems for unique column combinations (UCCs), functional dependencies (FDs), and inclusion dependencies (INDs). We show that the detection of UCCs and FDs is W[2]-complete when parameterized by the solution size. The discovery of inclusion-wise minimal UCCs is proven to be equivalent under parsimonious reductions to the transversal hypergraph problem of enumerating the minimal hitting sets of a hypergraph. The discovery of FDs is equivalent to the simultaneous enumeration of the hitting sets of multiple input hypergraphs. We further identify the detection of INDs as one of the first natural W[3]-complete problems. The discovery of maximal INDs is shown to be equivalent to enumerating the maximal satisfying assignments of antimonotone, 3-normalized Boolean formulas.
Modern routing algorithms reduce query time by depending heavily on preprocessed data. The recently developed Navigation Data Standard (NDS) enforces a separation between algorithms and map data, rendering preprocessing inapplicable. Furthermore, map data is partitioned into tiles with respect to their geographic coordinates. With the limited memory found in portable devices, the number of tiles loaded becomes the major factor for run time. We study routing under these restrictions and present new algorithms as well as empirical evaluations. Our results show that, on average, the most efficient algorithm presented uses more than 20 times fewer tile loads than a normal A*.
Through the use of next generation sequencing (NGS) technology, a lot of newly sequenced organisms are now available. Annotating those genes is one of the most challenging tasks in sequence biology. Here, we present an automated workflow to find homologue proteins, annotate sequences according to function and create a three-dimensional model.
Learning During COVID-19
(2021)
During the COVID-19 pandemic, learning in higher education and beyond shifted en masse to online formats, with the short- and long-term consequences for Massive Open Online Course (MOOC) platforms, learners, and creators still under evaluation. In this paper, we sought to determine whether the COVID-19 pandemic and this shift to online learning led to increased learner engagement and attainment in a single introductory biology MOOC through evaluating enrollment, proportional and individual engagement, and verification and performance data. As this MOOC regularly operates each year, we compared these data collected from two course runs during the pandemic to three pre-pandemic runs. During the first pandemic run, the number and rate of learners enrolling in the course doubled when compared to prior runs, while the second pandemic run indicated a gradual return to pre-pandemic enrollment. Due to higher enrollment, more learners viewed videos, attempted problems, and posted to the discussion forums during the pandemic. Participants engaged with forums in higher proportions in both pandemic runs, but the proportion of participants who viewed videos decreased in the second pandemic run relative to the prior runs. A higher percentage of learners chose to pursue a certificate via the verified track in each pandemic run, though a smaller proportion earned certification in the second pandemic run. During the pandemic, more enrolled learners did not necessarily correlate to greater engagement by all metrics. While verified-track learner performance varied widely during each run, the effects of the pandemic were not uniform for learners, much like in other aspects of life. As such, individual engagement trends in the first pandemic run largely resemble pre-pandemic metrics but with more learners overall, while engagement trends in the second pandemic run are less like pre-pandemic metrics, hinting at learner “fatigue”. This study serves to highlight the life-long learning opportunity that MOOCs offer is even more critical when traditional education modes are disrupted and more people are at home or unemployed. This work indicates that this boom in MOOC participation may not remain at a high level for the longer term in any one course, but overall, the number of MOOCs, programs, and learners continues to grow.
‘Heterosis’ is a term used in genetics and breeding referring to hybrid vigour or the superiority of hybrids over their parents in terms of traits such as size, growth rate, biomass, fertility, yield, nutrient content, disease resistance or tolerance to abiotic and abiotic stress. Parental plants which are two different inbred (pure) lines that have desired traits are crossed to obtain hybrids. Maximum heterosis is observed in the first generation (F1) of crosses. Heterosis has been utilised in plant and animal breeding programs for at least 90 years: by the end of the 21st century, 65% of worldwide maize production was hybrid-based. Generally, it is believed that an understanding of the molecular basis of heterosis will allow the creation of new superior genotypes which could either be used directly as F1 hybrids or form the basis for the future breeding selection programmes. Two selected accessions of a research model plant Arabidopsis thaliana (thale cress) were crossed to obtain hybrids. These typically exhibited a 60-80% increase of biomass when compared to the average weight of both parents. This PhD project focused on investigating the role of selected regulatory genes given their potentially key involvement in heterosis. In the first part of the project, the most appropriate developmental stage for this heterosis study was determined by metabolite level measurements and growth observations in parents and hybrids. At the selected stage, around 60 candidate regulatory genes (i.e. differentially expressed in hybrids when compared to parents) were identified. Of these, the majority were transcription factors, genes that coordinate the expression of other genes. Subsequent expression analyses of the candidate genes in biomass-heterotic hybrids of other Arabidopsis accessions revealed a differential expression in a gene subset, highlighting their relevance for heterosis. Moreover, a fraction of the candidate regulatory genes were found within DNA regions closely linked to the genes that underlie the biomass or growth heterosis. Additional analyses to validate the role of selected candidate regulatory genes in heterosis appeared insufficient to establish their role in heterosis. This uncovered a need for using novel approaches as discussed in the thesis. Taken together, the work provided an insight into studies on the molecular mechanisms underlying heterosis. Although studies on heterosis date back to more than one hundred years, this project as many others revealed that more investigations will be needed to uncover this phenomenon.
Editorial
(2018)
"Never doubt that a small group of thoughtful, committed citizens can change the world; indeed, it's the only thing that ever has. - Margaret Mead."
With the last issue of this year we want to point out directions towards what will come and what challenges and opportunities lie ahead of us. More needed than ever are joint creative efforts to find ways to collaborate and innovate in order to secure the wellbeing of our earth for the next generation to come. We have found ourselves puzzled that we could assemble a sustainability issue without having a call for papers or a special issue. In fact, many of the submissions we currently receive, deal with sustainable, ecological or novel approaches to management and organizations. As creativity and innovation are undisputable necessary ingredients for reaching the sustainable development goals, empirical proof and research in this area are still in their infancy. While the role of design and design thinking has been highlighted before for solving wicked societal problems, a lot more research is needed which creative and innovative ways organisations and societies can take to find solutions to climate change, poverty, hunger and education. We would therefore like to call to you, our readers and writers to tackle these problems with your research.
The first article in this issue addresses one of the above named challenges - the role of innovation for achieving the transition to a low-carbon energy world. In “Innovating for low-carbon energy through hydropower: Enabling a conservation charity's transition to a low-carbon community”, the authors John Gallagher, Paul Coughlan, A. Prysor Williams and Aonghus McNabola look at how an eco-design approach has supported a community transition to low-carbon. They highlight the importance of effective management as well as external collaboration and how the key for success lay in fostering an open environment for creativity and idea sharing. The second article addresses another of the grand challenges, the future of mobility and uses a design-driven approach to develop scenarios for mobility in cities. In “Designing radical innovations of meanings for society: envisioning new scenarios for smart mobility”, the authors Claudio Dell'Era, Naiara Altuna and Roberto Verganti investigate how new meanings can be designed and proposed to society rather than to individuals in the particular context of smart mobility. Through two case studies the authors argue for a multi-level perspective, taking the perspective of the society to solve societal challenges while considering the needs of the individual. The latter is needed because we will not change if our needs are not addressed. Furthermore, the authors find that both, meaning and technology need to be considered to create radical innovation for society. The role of meaning continues in the third article in this issue. The authors Marta Gasparin and William Green show in their article “Reconstructing meaning without redesigning products: The case of the Serie7 chair” how meaning changes over time even though the product remains the same. Through an in-depth retrospective study of the Serie 7 chair the authors investigate the relationship between meaning and the materiality of the object, and show the importance of materiality in constructing product meaning over long periods. Translating this meaning over the course of the innovation process is an important task of management in order to gain buy-in from all involved stakeholders. In the following article “A systematic approach for new technology development by using a biomimicry-based TRIZ contradiction matrix” the authors Byungun Yoon, Chaeguk Lim, Inchae Park and Dooseob Yoon develop a systematic process combining biomimicry and technology-based TRIZ in order to solve technological problems or develop new technologies based on completely new sources or combinations from technology and biology.
In the fifth article in this issue “Innovating via Building Absorptive Capacity: Interactive Effects of Top Management Support of Learning, Employee Learning Orientation, and Decentralization Structure” the authors Li-Yun Sun, Chenwei Li and Yuntao Dong examine the effect of learning-related personal and contextual factors on organizational absorptive capability and subsequent innovative performance. The authors find positive effects as well as a moderation influence of decentralized organizational decision-making structures. In the sixth article “Creativity within boundaries: social identity and the development of new ideas in franchise systems” the authors Fanny Simon, Catherine Allix-Desfautaux, Nabil Khelil and Anne-Laure Le Nadant address the paradox of balancing novelty and conformity for creativity in a franchise system. This research is one of the first we know to explicitly address creativity and innovation in such a rigid and pre-determined system. Using a social identity perspective, they can show that social control, which may be exerted by manipulating group identity, is an efficient lever to increase both the creation and the diffusion of the idea. Furthermore, they show that franchisees who do not conform to the norm of the group are stigmatized and must face pressure from the group to adapt their behaviors. This has important implications for future research. In the following article “Exploring employee interactions and quality of contributions in intra-organisational innovation platforms” the authors Dimitra Chasanidou, Njål Sivertstol and Jarle Hildrum examine the user interactions in an intra-organisational innovation platform, and also address the influence of user interactions for idea development. The authors find that employees communicate through the innovation platform with different interaction, contribution and collaboration types and propose three types of contribution qualities—passive, efficient and balanced contribution. In the eighth article “Ready for Take-off”: How Open Innovation influences startup success” Cristina Marullo, Elena Casprini, Alberto di Minin and Andrea Piccaluga seek to predict new venture success based on factors that can be observed in the pre-startup phase. The authors introduce different variables of founding teams and how these relate to startup success. Building on large-scale dataset of submitted business plans at UC Berkeley, they can show that teams with high skills diversity and past joint experience are a lot better able to prevent the risk of business failure at entry and to adapt the internal resources to market conditions. Furthermore, it is crucial for the team to integrate many external knowledge sources into their process (openness) in order to be successful. The crucial role of knowledge and how it is communicated and shared is the focal point of Natalya Sergeeva's and Anna Trifilova's article on “The role of storytelling in the innovation process”. They authors can show how storytelling has an important role to play when it comes to motivating employees to innovate and promoting innovation success stories inside and outside the organization. The deep human desire to hear and experience stories is also addressed in the last article in this issue “Gamification Approaches to the Early Stage of Innovation” by Rui Patricio, Antonio Moreira and Francesco Zurlo. Using gamification approaches at the early stage of innovation promises to create better team coherence, let employees experience fun and engagement, improve communication and foster knowledge exchange. Using an analytical framework, the authors analyze 15 articles that have looked at gamification in the context of innovation management before. They find that gamification indeed supports firms in becoming better at performing complex innovation tasks and managing innovation challenges. Furthermore, gamification in innovation creates a space for inspiration, improves creativity and the generation of high potential ideas.
Editorial
(2019)
Recent reports of increasing iron (Fe) concentrations in freshwaters are of concern, given the fundamental role of Fe in biogeochemical processes. Still, little is known about the frequency and geographical distribution of Fe trends or about the underlying drivers. We analyzed temporal trends of Fe concentrations across 340 water bodies distributed over 10 countries in northern Europe and North America in order to gain a clearer understanding of where, to what extent, and why Fe concentrations are on the rise. We found that Fe concentrations have significantly increased in 28% of sites, and decreased in 4%, with most positive trends located in northern Europe. Regions with rising Fe concentrations tend to coincide with those with organic carbon (OC) increases. Fe and OC increases may not be directly mechanistically linked, but may nevertheless be responding to common regional-scale drivers such as declining sulfur deposition or hydrological changes. A role of hydrological factors was supported by covarying trends in Fe and dissolved silica, as these elements tend to stem from similar soil depths. A positive relationship between Fe increases and conifer cover suggests that changing land use and expanded forestry could have contributed to enhanced Fe export, although increases were also observed in nonforested areas. We conclude that the phenomenon of increasing Fe concentrations is widespread, especially in northern Europe, with potentially significant implications for wider ecosystem biogeochemistry, and for the current browning of freshwaters.
A quote from Fight Club (Chuck Palahniuk, 1996) may seem unusual for a Classicist. Nevertheless, this famous sentence summarises the contents of this special issue of thersites perfectly. As specialists in classical reception frequently witness, there is a sort of déjà-vu effect when it comes to the presence of Antiquity within popular culture. In 2019, to try to better understand the phenomenon, Antiquipop invited researchers to take an interest in the construction and semantic path of these “masterpieces” in contemporary popular culture, with a particular focus on the 21st century.
Marine and limnic particles are hotspots of organic matter mineralization significantly affecting biogeochemical element cycling. Fluorescence in-situ hybridization and pyrosequencing of 16S rRNA genes were combined to investigate bacterial diversity and community composition on limnic and coastal marine particles >5 and >10m respectively. Limnic particles were more abundant (average: 1x10(7)l(-1)), smaller in size (average areas: 471 versus 2050m(2)) and more densely colonized (average densities: 7.3 versus 3.6 cells 100m(-2)) than marine ones. Limnic particle-associated (PA) bacteria harboured Alphaproteobacteria and Betaproteobacteria, and unlike previously suggested sizeable populations of Gammaproteobacteria, Actinobacteria and Bacteroidetes. Marine particles were colonized by Planctomycetes and Betaproteobacteria additionally to Alphaproteobacteria, Bacteroidetes and Gammaproteobacteria. Large differences in individual particle colonization could be detected. High-throughput sequencing revealed a significant overlap of PA and free-living (FL) bacteria highlighting an underestimated connectivity between both fractions. PA bacteria were in 14/21 cases more diverse than FL bacteria, reflecting a high heterogeneity in the particle microenvironment. We propose that a ratio of Chao 1 indices of PA/FL<1 indicates the presence of rather homogeneously colonized particles. The identification of different bacterial families enriched on either limnic or marine particles demonstrates that, despite the seemingly similar ecological niches, PA communities of both environments differ substantially.
The dynamics and activities of microbes colonizing organic particles (hereafter particles) greatly determine the efficiency of the aquatic carbon pump. Current understanding is that particle composition, structure and surface properties, determined mostly by the forming organisms and organic matter, dictate initial microbial colonization and the subsequent rapid succession events taking place as organic matter lability and nutrient content change with microbial degradation. We applied a transcriptomic approach to assess the role of stochastic events on initial microbial colonization of particles. Furthermore, we asked whether gene expression corroborates rapid changes in carbon-quality. Commonly used size fractionated filtration averages thousands of particles of different sizes, sources, and ages. To overcome this drawback, we used replicate samples consisting each of 3–4 particles of identical source and age and further evaluated the consequences of averaging 10–1000s of particles. Using flow-through rolling tanks we conducted long-term experiments at near in situ conditions minimizing the biasing effects of closed incubation approaches often referred to as “the bottle-effect.” In our open flow-through rolling tank system, however, active microbial communities were highly heterogeneous despite an identical particle source, suggesting random initial colonization. Contrasting previous reports using closed incubation systems, expression of carbon utilization genes didn’t change after 1 week of incubation. Consequently, we suggest that in nature, changes in particle-associated community related to carbon availability are much slower (days to weeks) due to constant supply of labile, easily degradable organic matter. Initial, random particle colonization seems to be subsequently altered by multiple organismic interactions shaping microbial community interactions and functional dynamics. Comparative analysis of thousands particles pooled togethers as well as pooled samples suggests that mechanistic studies of microbial dynamics should be done on single particles. The observed microbial heterogeneity and inter-organismic interactions may have important implications for evolution and biogeochemistry in aquatic systems.
In winter 2009/10, a sudden under-ice bloom of heterotrophic bacteria occurred in the seasonally ice-covered, temperate, deep, oligotrophic Lake Stechlin (Germany). Extraordinarily high bacterial abundance and biomass were fueled by the breakdown of a massive bloom of Aphanizomenon flos-aquae after ice formation. A reduction in light resulting from snow coverage exerted a pronounced physiological stress on the cyanobacteria. Consequently, these were rapidly colonized, leading to a sudden proliferation of attached and subsequently of free-living heterotrophic bacteria. Total bacterial protein production reached 201 mg C L-1 d(-1), ca. five times higher than spring-peak values that year. Fluorescence in situ hybridization and denaturing gradient gel electrophoresis at high temporal resolution showed pronounced changes in bacterial community structure coinciding with changes in the physiology of the cyanobacteria. Pyrosequencing of 16S rRNA genes revealed that during breakdown of the cyanobacterial population, the diversity of attached and free-living bacterial communities were reduced to a few dominant families. Some of these were not detectable during the early stages of the cyanobacterial bloom indicating that only specific, well adapted bacterial communities can colonize senescent cyanobacteria. Our study suggests that in winter, unlike commonly postulated, carbon rather than temperature is the limiting factor for bacterial growth. Frequent phytoplankton blooms in ice-covered systems highlight the need for year-round studies of aquatic ecosystems including the winter season to correctly understand element and energy cycling through aquatic food webs, particularly the microbial loop. On a global scale, such knowledge is required to determine climate change induced alterations in carbon budgets in polar and temperate aquatic systems.
Six new bifunctional bis(trithiocarbonate)s were explored as RAFT agents for synthesizing amphiphilic triblock copolymers ABA and BAB, with hydrophilic "A" blocks made from N-isopropylacrylamide and hydrophobic "B" blocks made from styrene. Whereas the extension of poly(N-isopropylacrylamide) by styrene was not effective, polystyrene macroRAFT agents provided the block copolymers efficiently. End group analysis by H-1 NMR spectroscopy supported molar mass analysis and revealed an unexpected side reaction for certain bis(trithiocarbonate)s, namely a fragmentation to simple trithiocarbonates while extruding ethylene-trithiocarbonate. The amphiphilic block copolymers with short polystyrene blocks are directly soluble in water and self-organize into thermo-responsive micellar aggregates.
Several series of symmetrical triblock copolymers were synthesized by the reversible addition fragmentation chain transfer method. They consist of a long block of poly(N-isopropylacrylamide) as hydrophilic, thermoresponsive middle block, which is end-capped by two small strongly hydrophobic blocks made from five different vinyl polymers. The association of the amphiphilic polymers was studied in dilute and concentrated aqueous solution. The polymer micelles found at low concentrations form hydrogels at high concentrations, typically above 30-35 wt.%. Hydrogel formation and the thermosensitive rheological behavior were studied exemplarily for copolymers with hydrophobic blocks of polystyrene, poly(2-ethylhexyl acrylate), and poly(n-octadecyl acrylate). All systems exhibited a cloud point around 30 A degrees C. Heating beyond the cloud point initially favors hydrogel formation but continued heating results in macroscopic phase separation. The rheological behavior suggests that the copolymers associate into flower-like micelles, with only a small share of polymers that bridge the micelles and act as physical cross-linkers, even at high concentrations.
This work presents the synthesis and the self-assembly of symmetrical amphiphilic ABA and BAB triblock copolymers in dilute, semi-concentrated and highly concentrated aqueous solution. A series of new bifunctional bistrithiocarbonates as RAFT agents was used to synthesise these triblock copolymers, which are characterised by a long hydrophilic middle block and relatively small, but strongly hydrophobic end blocks. As hydrophilic A blocks, poly(N-isopropylacrylamide) (PNIPAM) and poly(methoxy diethylene glycol acrylate) (PMDEGA) were employed, while as hydrophobic B blocks, poly(4-tert-butyl styrene), polystyrene, poly(3,5-dibromo benzyl acrylate), poly(2-ethylhexyl acrylate), and poly(octadecyl acrylate) were explored as building blocks with different hydrophobicities and glass transition temperatures. The five bifunctional trithiocarbonates synthesised belong to two classes: the first are RAFT agents, which position the active group of the growing polymer chain at the outer ends of the polymer (Z-C(=S)-S-R-S-C(=S)-Z, type I). The second class places the active groups in the middle of the growing polymer chain (R-S-C(=S)-Z-C(=S)-S-R, type II). These RAFT agents enable the straightforward synthesis of amphiphilic triblock copolymers in only two steps, allowing to vary the nature of the hydrophobic blocks as well as the length of the hydrophobic and hydrophilic blocks broadly with good molar mass control and narrow polydispersities. Specific side reactions were observed among some RAFT agents including the elimination of ethylenetrithiocarbonate in the early stage of the polymerisation of styrene mediated by certain agents of the type II, while the use of the RAFT agents of type I resulted in retardation of the chain extension of PNIPAM with styrene. These results underline the need of a careful choice of RAFT agents for a given task. The various copolymers self-assemble in dilute and semi-concentrated aqueous solution into small flower-like micelles. No indication for the formation of micellar clusters was found, while only at high concentration, physical hydrogels are formed. The reversible thermoresponsive behaviour of the ABA and BAB type copolymer solutions in water with A made of PNIPAM was examined by turbidimetry and dynamic light scattering (DLS). The cloud point of the copolymers was nearly identical to the cloud point of the homopolymer and varied between 28-32 °C with concentrations from 0.01 to 50 wt%. This is attributed to the formation of micelles where the hydrophobic blocks are shielded from a direct contact with water, so that the hydrophobic interactions of the copolymers are nearly the same as for pure PNIPAM. Dynamic light scattering measurements showed the presence of small micelles at ambient temperature. The aggregate size dramatically increased above the cloud point, indicating a change of aggregate morphology into clusters due to the thermosensitivity of the PNIPAM block. The rheological behaviour of the amphiphilic BAB triblock copolymers demonstrated the formation of hydrogels at high concentrations, typically above 30-35 wt%. The minimum concentration to induce hydrogels decreased with the increasing glass transition temperatures and increasing length of the end blocks. The weak tendency to form hydrogels was attributed to a small share of bridged micelles only, due to the strong segregation regime occurring. In order to learn about the role of the nature of the thermoresponsive block for the aggregation, a new BAB triblock copolymer consisting of short polystyrene end blocks and PMDEGA as stimuli-responsive middle block was prepared and investigated. Contrary to PNIPAM, dilute aqueous solutions of PMDEGA and of its block copolymers showed reversible phase transition temperatures characterised by a strong dependence on the polymer composition. Moreover, the PMDEGA block copolymer allowed the formation of physical hydrogels at lower concentration, i.e. from 20 wt%. This result suggests that PMDEGA has a higher degree of water-swellability than PNIPAM.
A chemotaxonomic evaluation using hplc profiling was undertaken to resolve the infrageneric and intergeneric affinities of over 150 strains of Xylariaceae. Daldinia placentiformis, Hypoxylon nicaraguense, H. polyporus, and Phylacia sagrana were found to contain 8-methoxy-1-naphthol, which is apparently absent in Annulohypoxylon, Hypoxylon, and related genera with bipartite stromata. D. placentiformis and other species of Daldinia and Entonaema produced this naphthol, 5-hydroxy-2-methylchromone, isosclerone derivatives, and 'AB-5046' phytotoxins. Phylacia sagrana differed from most Daldinia spp., except for D. caldariorum, by producing eutypine derivatives in addition to the above compounds. indolylquinones were observed in H. nicaraguense and H. polyporus. Isosclerones were also identified in the A. multiforme complex, but Hypoxylon and other Annulohypoxylon and most Hypoxylon spp. studied Annulohypoxylon spp. contained S-methylmellein as the major metabolite of their cultures. Based on the occurrence of the above metabolites, further mellein-type dihydroisocoumarins, teleomorphic and anamorphic Xylariaceae with Nodulisporium-like anamorphs ('Hypoxyloideae') were divided into various chemotypes. A comparison of their 5.8S/ ITS nuc-rDNA sequences agreed in some important aspects with the above results: H. nicaraguense and H. polyporus appeared basal to a clade comprising Daldinia, Entonaema, and Ph. sagrana. The latter species appeared allied to D. caldariorum, but was distantly related to Pyrenomyxa morganii and Hypoxylon s. str. (C) 2007 The British Mycological Society. Published by Elsevier Ltd. All rights reserved.
Since 9/11, the fight against the financial sources of terrorism has become a major arena for international co-operation. In the first part, the paper highlights the borderline between security studies and international political economy. The second part of the paper asks how successful the international community is in this fight. The authors show that the idea of seizing terrorist funds and denying access to the international financial system is not a very promising one. They conclude that, so far, results have been mixed and that only a political approach to the problem promises a solution.
Eine königliche Mission
(2017)
In integrated medical considerations of the biological human system, both intellectual and motor performances in a similar manner are considered as a result of the function of the nervous system. Consequently, universal minimal dysfunctions of the central nervous system may lead to both intellectual and physical anomalies. Therefore, this study tests the hypothesis that there is a connection between the balance ability as a motor parameter and school success as an intellectual parameter. A postural measuring system based on the force-moment sensor technique was used to record the postural balance regulation of 773 children (circle divide 11 +/- 1 years). The school achievement of each child was determined by school grades. Data analysis was performed by linear as well as by nonlinear time series analyses. There are highly significant differences in balance regulation between good and poor pupils recognized by several linear and nonlinear parameters. Good pupils could be discriminated from pupils with bad results in learning to 80 %. The results support the hypothesis mentioned above. One possible explanation for the poor regulation of balance in bad learners could be a deficit in the neural maturity. In future, further developments will be targeted on higher discrimination levels, possibly in order to predict school success. On the other hand, the effects of special movement exercises on the neural development in childhood will be the focus in our further work
The manual muscle test (MMT) is a flexible diagnostic tool, which is used in many disciplines, applied in several ways. The main problem is the subjectivity of the test. The MMT in the version of a “break test” depends on the tester’s force rise and the patient’s ability to resist the applied force. As a first step, the investigation of the reproducibility of the testers’ force profile is required for valid application. The study examined the force profiles of n = 29 testers (n = 9 experiences (Exp), n = 8 little experienced (LitExp), n = 12 beginners (Beg)). The testers performed 10 MMTs according to the test of hip flexors, but against a fixed leg to exclude the patient’s reaction. A handheld device recorded the temporal course of the applied force. The results show significant differences between Exp and Beg concerning the starting force (padj = 0.029), the ratio of starting to maximum force (padj = 0.005) and the normalized mean Euclidean distances between the 10 trials (padj = 0.015). The slope is significantly higher in Exp vs. LitExp (p = 0.006) and Beg (p = 0.005). The results also indicate that experienced testers show inter-tester differences and partly even a low intra-tester reproducibility. This highlights the necessity of an objective MMT-assessment. Furthermore, an agreement on a standardized force profile is required. A suggestion for this is given.
The manual muscle test (MMT) is a flexible diagnostic tool, which is used in many disciplines, applied in several ways. The main problem is the subjectivity of the test. The MMT in the version of a “break test” depends on the tester’s force rise and the patient’s ability to resist the applied force. As a first step, the investigation of the reproducibility of the testers’ force profile is required for valid application. The study examined the force profiles of n = 29 testers (n = 9 experiences (Exp), n = 8 little experienced (LitExp), n = 12 beginners (Beg)). The testers performed 10 MMTs according to the test of hip flexors, but against a fixed leg to exclude the patient’s reaction. A handheld device recorded the temporal course of the applied force. The results show significant differences between Exp and Beg concerning the starting force (padj = 0.029), the ratio of starting to maximum force (padj = 0.005) and the normalized mean Euclidean distances between the 10 trials (padj = 0.015). The slope is significantly higher in Exp vs. LitExp (p = 0.006) and Beg (p = 0.005). The results also indicate that experienced testers show inter-tester differences and partly even a low intra-tester reproducibility. This highlights the necessity of an objective MMT-assessment. Furthermore, an agreement on a standardized force profile is required. A suggestion for this is given.
Zur Nachhaltigkeit der Wirkung eines apparativ unterstützenden Dehn- und Relaxationsverfahrens
(2002)