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Ab Mitte der 1820er Jahre erfuhr die Mikroskop- Technik eine stürmische Entwicklung. Dadurch, dass es gelang, nach und nach die optischen Fehler zu korrigieren, verbesserte sich die Auflösung bis zum Ende des Jahrhunderts um den Faktor 10 von 3 μm auf 0,3 μm. Um 1820 begann Christian Gottfried Ehrenberg mit mikroskopischen Untersuchungen. Er nutzte zunächst ein einfaches Nürnberger Mikroskop. 1832 erwarb er ein Mikroskop aus der Berliner Werkstatt von Pistor & Schiek, das er dann zeitlebens nutzte. Ein Vergleich der Leistungsfähigkeit seines Instruments mit der für seine Untersuchungen notwendigen Auflösung zeigt, dass es für seine Untersuchungen vollkommen genügte. Für seine Untersuchungsobjekte entwickelte er Präparationstechniken und Aufbewahrungsmethoden für die Dauerpräparate. Da er auch die mikroskopischen Abbildungen bis hin zu den Vorlagen für die Kupfertafeln selbst anfertigte, behielt er den gesamten Prozess von der Präparation bis zum Druck der Ergebnisse stets in der Hand.
Als langjähriges und aktives Mitglied der Gesellschaft Naturforschender Freunde zu Berlin bestimmte Ehrenberg ihre Aktivitäten und ihr Ansehen maßgeblich mit. Seine Beiträge zu den Sitzungen und Schriften und seine Rolle als Bewohner des gesellschaftseigenen Hauses förderten in der GNF sowohl Fortschritt als auch Beständigkeit. Das Ziel der Naturgeschichte des 18. Jahrhunderts, also die Entdeckung, Beschreibung und Bewahrung möglichst aller Organismen- und Gesteinsarten, wurde in der GNF bis in die zweite Hälfte des 19. Jahrhunderts tradiert. Ehrenbergs wissenschaftliche Leistungen, insbesondere seine zahlreichen Entdeckungen mit Hilfe des Mikroskops, stehen ganz in dieser Tradition.
Die Geschichte der Mikrobiologie als Laborwissenschaft des späten 19. Jahrhunderts hat für Ehrenberg keinen Platz. Unmodern, ja fehlerhaft scheinen die Befunde dieses „Humboldt en miniature“, der die Belebtheit von Wasser oder Luft mikroskopisch untersuchte, der Proben aus aller Welt sammelte und so zahlreiche „Infusorien“ genannte Mikroben sowie deren Effekte etwa bei Blutwundern beschrieb, deren Beteiligung an Infektionskrankheiten aber verneinte. Zugleich scheint sein ökologischer Blick auf den Mikrokosmos die Gegenwart auf überraschende Weise anzusprechen – einerseits weil Mikroben omnipräsentes Faszinosum wie Bedrohung bleiben, andererseits weil viele der Prämissen von Pasteur und Koch im Zeitalter der Genomik überholt erscheinen. Ausgehend von der zwiespältigen Position Ehrenbergs fragt dieser Artikel, warum er möglicherweise gerade deswegen spannender ist, als ihn die Historiographie bislang hat erscheinen lassen.
Im Jahr 1820 traten zwei Universitätsabsolventen, Christian Gottfried Ehrenberg und Wilhelm Hemprich, eine Forschungsreise nach Nordafrika an, die eine der ersten vom preußischen Staat maßgeblich getragenen Reiseunternehmungen darstellt. Wesentliches Ziel der Reise war das Sammeln von naturkundlichen Exemplaren für die junge Berliner Museumslandschaft. Der Beitrag ordnet die afrikanische Forschungsreise in die wissenschaftliche Laufbahn Ehrenbergs ein, der als einziger Reisender überlebte, sowie in die Geschichte der Berliner Wissenschaftslandschaft im frühen 19. Jahrhundert. Dabei konzentriert sich der Beitrag auf die Medien – insbesondere Sammlungsverzeichnisse und Sammlungsobjekte – die die Reisenden im Feld einsetzen mussten, um ihre Identität als gelehrte Naturforscher gegenüber ihren Förderern zu inszenieren und damit ihre Position in der preußischen Wissenschaft strategisch zu sichern.
The Russian-Siberian journey, carried out with Alexander von Humboldt and Gustav Rose in 1829 coincided with a decisive phase in Christian Gottfried Ehrenberg’s scientific career. His field diary and the drawings he made on the trip document his intensified focus on the study of microorganisms. The numerous observations on plant and animal geography show how Ehrenberg tested a combination of micro- and macro-perspectives that would shape his research on infusoria in the following decades: In addition to the task of classification at the microscope, Ehrenberg carried out worldwide comparative research on the distribution of microorganisms.
Die Erforschung und Beschreibung mikroskopischer Organismen durch Christian Gottfried Ehrenberg ist durch seine publizierten Texte und Kupfertafeln in den „Infusionsthierchen“, der „Mikrogeologie“ sowie aus Abhandlungen der Akademie der Wissenschaften überliefert. Zentrale Bedeutung haben seine Zeichenblätter, anfangs alleinige Dokumentation, später komplementiert durch tausende mikroskopischer Dauerpräparate rezenter und fossiler Kieselschalen sowie getrockneter Einzeller. Alle Originalmaterialien Ehrenbergs stehen für die aktuelle Forschung in der Ehrenbergsammlung zur Verfügung. Seine detailgenauen Zeichnungen dienten der Erstbeschreibung einer Vielzahl neuer Arten aus allen Weltteilen. Biogeografische und ökologische Fragestellungen, Beschreibungen von Lebenszyklen sowie außerordentliche Phänomene wie die Färbung von Gewässern und Erden wurden mithilfe zeichnerischer Analysen bearbeitet.
Geleitwort
(2021)
Heinrich Menu von Minutoli unternahm 1820 eine Reise nach Nordafrika zur Erforschung ägyptischer und griechischer Altertümer. Die Preußische Akademie der Wissenschaften bestimmte die jungen Naturforscher Christian Gottfried Ehrenberg und Wilhelm Hemprich als weitere Teilnehmer.
Während Minutoli bereits ein Jahr nach Beginn der Expedition 1821 nach Europa zurückkehrte, setzten Ehrenberg und Hemprich ihre Forschungen fort. Von Alexandria aus unternahmen sie, zum Teil getrennt, Exkursionen in die libysche Wüste, auf die Sinaihalbinsel, zum Roten Meer, in das Libanongebirge sowie bis in den Sudan und nach Eritrea, wo Hemprich 1825 dem Malariafieber erlag.
Wie von der Akademie der Wissenschaften beauftragt, sammelten Ehrenberg und Hemprich insgesamt 34 000 Tiere, 46 000 Pflanzen und 300 Mineralien. Diese trafen im Laufe der Jahre, verpackt in insgesamt 114 Kisten, in Berlin ein. Die Akademie stellte Mittel für die Auswertung der Sammlungen zur Verfügung. Ehrenbergs Reisebericht blieb aber ebenso Fragment wie das großangelegte Tafelwerk Symbolae physicae.
„Eine der größten Freuden meines Lebens würde sein, einmal 5 – 6 Monathe mit Ihnen, an Ihrer Seite, unter Ihrer Belehrung reisen zu können. Süßwassermuscheln, Fische, Bergpflanzen Rußlands sind wenig bekannt.“ Mit diesen Worten lud Alexander von Humboldt seinen Akademiekollegen Ehrenberg zur Teilnahme an der russisch-sibirischen Reise ein, die der preußische Kammerherr auf Einladung des Kaisers Nikolaj I. unternahm. Knapp drei Jahre nach der Rückkehr von der arabisch-afrikanischen Forschungsreise brach Ehrenberg also erneut auf: Am 12. April 1829 traten Humboldt, Ehrenberg und der Mineraloge Gustav Rose ihre Reise in Berlin an. Diese führte sie in knapp neun Monaten und über 19 000 Kilometer in den Ural und durch Westsibirien bis zur russisch-chinesischen Grenzstation Baty. Während Humboldt und Rose die Hüttenbezirke im Ural und Altai inspizierten, legte Ehrenberg botanische und zoologische Sammlungen an.
Nach den beiden großen Forschungsreisen konzentrierte Ehrenberg seine Arbeit in Berlin auf die systematische Beschreibung von Kleinstlebewesen, die sogenannten Infusorien. 1838 erschien eines seiner Hauptwerke, Die Infusionsthierchen als vollkommene Organismen. Ein Blick in das tiefere organische Leben der Natur. Ehrenberg untersuchte tausende Proben aus aller Welt und wies Infusorien auf dem Grund der Weltmeere, in atmosphärischem Staub und in Hochgebirgen nach. Ausgehend von diesen Befunden beschäftigte er sich mit dem Anteil einzelliger kieselschaliger Mikroorganismen an der Bildung von Erden und geologischen Formationen. 1854 legte er die Mikrogeologie vor: In 41 Bildtafeln gab er weltweite „geographische Uebersichten über das kleine jetzige erdbildende Leben“. Christian Gottfried Ehrenberg gilt als Mitbegründer der Boden-Mikrobiologie und Mikropaläontologie sowie als Pionier der Kieselalgenforschung und Protozoologie.
Настоящий научно-практический комментарий и перевод Уголовного уложения Федеративной Республики Германия не ограничивается собственно трансформацией текста основного уголовного закона Германии на русский язык. Руководствуясь принципами функционального перевода, автор посредством точного и систематического перевода доводит до сведения читателя смысл уголовно-правовых норм. Научно-практический комментарий к Уголовному уложению Германии представляет собой постатейный комментарий, учитывающий как мнение законодателя, так и мнение правоприменительной практики Федерального Верховного суда и высших Земельных судов Германии, а также немецкой юридической доктрины по основным проблемам уголовного права. Необходимое внимание было уделено также дополнительному уголовному праву и уголовно-процессуальным проблемам. Таким образом, задачей настоящего издания является предоставить читателю возможность правильного языкового понимания и юридического толкования уголовно-правовых норм Германии.
Вступительная статья «Введение в уголовное право Германии» содержит общий обзор немецкого уголовного права. Особое внимание уделено развитию и источникам уголовного законодательства, а также доктрине уголовного права ФРГ.
Книга может заинтересовать практиков и правоведов, а также всех, кто в своей профессиональной деятельности или в процессе обучения сталкивается с уголовным правом Германии.
Mehr Schein als Sein
(2021)
In this paper I am concerned with the idiomatic constructions fr. avoir l'air (de) and sp. tener el aire (de). I describe these form-function pairs from a constructionist perspective and analyze them as cases of evidential strategies in French and Spanish.
The incorporation of proteins in artificial materials such as membranes offers great opportunities to avail oneself the miscellaneous qualities of proteins and enzymes perfected by nature over millions of years. One possibility to leverage proteins is the modification with artificial polymers. To obtain such protein-polymer conjugates, either a polymer can be grown from the protein surface (grafting-from) or a pre-synthesized polymer attached to the protein (grafting-to). Both techniques were used to synthesize conjugates of different proteins with thermo-responsive polymers in this thesis.
First, conjugates were analyzed by protein NMR spectroscopy. Typical characterization techniques for conjugates can verify the successful conjugation and give hints on the secondary structure of the protein. However, the 3-dimensional structure, being highly important for the protein function, cannot be probed by standard techniques. NMR spectroscopy is a unique method allowing to follow even small alterations in the protein structure. A mutant of the carbohydrate binding module 3b (CBM3bN126W) was used as model protein and functionalized with poly(N-isopropylacrylamide). Analysis of conjugates prepared by grafting-to or grafting-from revealed a strong impact of conjugation type on protein folding. Whereas conjugates prepared by grafting a pre-formed polymer to the protein resulted in complete preservation of protein folding, grafting the polymer from the protein surface led to (partial) disruption of the protein structure.
Next, conjugates of bovine serum albumin (BSA) as cheap and easily accessible protein were synthesized with PNIPAm and different oligoethylene glycol (meth)acrylates. The obtained protein-polymer conjugates were analyzed by an in-line combination of size exclusion chromatography and multi-angle laser light scattering (SEC-MALS). This technique is particular advantageous to determine molar masses, as no external calibration of the system is needed. Different SEC column materials and operation conditions were tested to evaluate the applicability of this system to determine absolute molar masses and hydrodynamic properties of heterogeneous conjugates prepared by grafting-from and grafting-to. Hydrophobic and non-covalent interactions of conjugates lead to error-prone values not in accordance to expected molar masses based on conversions and extents of modifications.
As alternative to this method, conjugates were analyzed by sedimentation velocity analytical ultracentrifugation (SV-AUC) to gain insights in the hydrodynamic properties and how they change after conjugation. Within a centrifugal field, a sample moves and fractionates according to the mass, density, and shape of its individual components. Conjugates of BSA with PNIPAm were analyzed below and above the cloud point temperature of the thermo-responsive polymer component. It was identified that the polymer characteristics were transferred to the conjugate molecule which than showed a decreased ideality – defined as increased deviation from a perfect sphere model – below and increased ideality above the cloud point temperature. This effect can be attributed to an arrangement of the polymer chain pointing towards the solvent (expanded state) or snuggling around the protein surface depending on the applied temperature.
The last project dealt with the synthesis of ferric hydroxamate uptake protein component A (FhuA)-polymer conjugates as building blocks for novel membrane materials. The shape of FhuA can be described as barrel and removal of a cork domain inside the protein results in a passive channel aimed to be utilized as pores in the membrane system. The polymer matrix surrounding the membrane protein is composed of a thermo-responsive and a UV-crosslinkable part. Therefore, an external trigger for covalent immobilization of these building blocks in the membrane and switchability of the membrane between different states was incorporated. The overall performance of membranes prepared by a drying-mediated self-assembly approach was evaluated by permeability and size exclusion experiments. The obtained membranes displayed an insufficiency in interchain crosslinking and therefore a lack in performance. Furthermore, the aimed switch between a hydrophilic and hydrophobic state of the polymer matrix did not occur. Correspondingly, size exclusion experiments did not result in a retention of analytes larger than the pores defined by the dimension of the used FhuA variant.
Overall, different paths to generate protein-polymer conjugates by either grafting-from or grafting-to the protein surface were presented paving the way to the generation of new hybrid materials. Different analytical methods were utilized to describe the folding and hydrodynamic properties of conjugates providing a deeper insight in the overall characteristics of these seminal building blocks.
Halide perovskites are a class of novel photovoltaic materials that have recently attracted much attention in the photovoltaics research community due to their highly promising optoelectronic properties, including large absorption coefficients and long carrier lifetimes. The charge carrier mobility of halide perovskites is investigated in this thesis by THz spectroscopy, which is a contact-free technique that yields the intra-grain sum mobility of electrons and holes
in a thin film.
The polycrystalline halide perovskite thin films, provided from Potsdam University, show moderate mobilities in the range from 21.5 to 33.5 cm2V-1s-1. It is shown in this work that the room temperature mobility is limited by charge carrier scattering at polar optical phonons. The mobility at low temperature is likely to be limited by scattering at charged and neutral impurities at impurity concentration N=1017-1018 cm-3. Furthermore, it is shown that exciton formation
may decrease the mobility at low temperatures. Scattering at acoustic phonons can be neglected at both low and room temperatures. The analysis of mobility spectra over a broad range of temperatures for perovskites with various cation compounds shows that cations have a minor impact on charge carrier mobility.
The low-dimensional thin films of quasi-2D perovskite with different numbers of [PbI6]4−sheets (n=2-4) alternating with long organic spacer molecules were provided by S. Zhang from Potsdam University. They exhibit mobilities in the range from 3.7 to 8 cm2V-1s-1. A clear
decrease of mobility is observed with decrease in number of metal-halide sheets n, which likely arises from charge carrier confinement within metal-halide layers. Modelling the measured THz mobility with the modified Drude-Smith model yields localization length from 0.9 to 3.7 nm, which agrees well on the thicknesses of the metal-halide layers. Additionally, the mobilities are found to be dependent on the orientation of the layers. The charge carrier dynamics is also
dependent on the number of metal-halide sheets n. For the thin films with n =3-4 the dynamics is similar to the 3D MHPs. However, the thin film with n = 2 shows clearly different dynamics, where the signs of exciton formation are observed within 390 fs timeframe after
photoexcitation.
Also, the charge carrier dynamics of CsPbI3 perovskite nanocrystals was investigated, in particular the effect of post treatments on the charge carrier transport.
In den letzten Jahren erlebte der Rechtspopulismus in Europa einen Aufstieg. Die ‚Alternative für Deutschland‘ (AfD) erhielt bei der deutschen Bundestagswahl 2017 beispielsweise 12,7 % der abgegebenen Stimmen und war darüber hinaus gerade im Osten des Landes erfolgreich. Im Rahmen dieser Arbeit wird vergleichend untersucht, welche sprachlichen Manipulationsstrategien der AfD dazu beitragen und wie sie wirken. Die Arbeit gliedert sich grob in zwei Teile: die Analyse des Sprachgebrauchs der AfD und schließlich der Vergleich mit jenem der Nationalsozialist:innen. Ziel der Arbeit ist es nicht, die AfD als Kopie der NSDAP zu entlarven, sondern ihre sprachlichen Manipulationsstrategien im historischen Kontext ergebnisoffen zu analysieren und so ein tieferes Verständnis dieser zu ermöglichen, um eine Grundlage für die zukünftige Erarbeitung möglicher Gegenstrategien zu schaffen.
Dabei stellt sich die Verwendung von diskriminierenden Sprechakten als wesentlicher Teilaspekt der Strategie heraus. So kann aus den Ergebnissen geschlussfolgert werden, dass die Polarisierung der Gesellschaft in zwei Teile (Ingroup und Outgroup) sowie die damit verbundene Diskriminierung der Outgroup als Ziel des Sprachgebrauchs der AfD bezeichnet werden können. Auf diesem Weg kann eine zunehmende Radikalisierung des Sprachgebrauchs innerhalb der letzten Jahre festgestellt werden.
Im zweiten Teil der Arbeit werden im Vergleich mit den Nationalsozialist:innen zahlreiche Parallelen deutlich: Über gemeinsame Stilmittel wie Metaphorik, Verwendung von Superlativen oder bestimmten Begrifflichkeiten hinaus ist hier vor allem die Diskriminierung eines konkreten Feindbildes sowie die angestrebte Spaltung der Bevölkerung zu nennen. Zugleich gilt es auch, die deutlichen Unterschiede zwischen dem Sprachgebrauch im Nationalsozialismus und jenem der AfD zu akzentuieren, um eine ebenso leichtfertige wie unangemessene Gleichsetzung zu verhindern. Zentral ist hier die Eindeutigkeit des Sprachgebrauchs. Die Vergleiche mit verschiedenen Quellen aus dem Dritten Reich verdeutlichen, dass der Sprachgebrauch im Nationalsozialismus direkter und viel radikaler war. Die AfD ist hingegen oftmals darauf bedacht, ihre Aussagen nur augenscheinlich eindeutig zu formulieren, sich insgesamt aber immer eine Möglichkeit des sprachlichen Zurückruderns offen zu halten. Ein offensichtlicher Grund dürften die unterschiedlichen gesellschaftlichen Bedingungen zu beiden Zeiten sein. Für die AfD ist es heute schwieriger, eine ausreichend große Masse an mindestens unsicheren Menschen zu mobilisieren. Begründet werden kann dies mit einer im Vergleich zur Weimarer Republik über Jahrzehnte hinweg gesetzlich, politisch und gesellschaftlich etablierten und sehr stabilen Demokratie. Deshalb ist die AfD darauf angewiesen, eine mehrdeutige Sprache zu verwenden, die ihnen im Bedarfsfall eine Rechtfertigung und somit einen Weg zurück ermöglicht. Darüber hinaus ermöglicht ihnen ein solcher Sprachgebrauch aber auch, sich einerseits gegenüber den Institutionen der Demokratie (beispielsweise dem Verfassungsschutz) zu rechtfertigen und andererseits insbesondere der konservativen Wählerschaft das Gefühl zu geben, dass sie keine rechtsextreme Partei wählen.
Aus den Ergebnissen der Arbeit lässt sich darüber hinaus die These ableiten, dass eine Veränderung des Sprachgebrauchs allein nicht dazu führt, dass Menschen einer Ideologie folgen. Der historische Vergleich deutet aber darauf hin, dass ein diskriminierender Sprachgebrauch zur Entstehung eines Nährbodens einer solchen Ideologie beitragen kann, wenn der gesellschaftliche und politische Rahmen es zulässt. Diesen Rahmen versucht die AfD Stück für Stück in ihrem Sinne zu verschieben. In den letzten Jahren gelang es ihr zunehmend, den öffentlichen Diskurs zu ihren Gunsten mitzubestimmen und zu verändern. Dafür ist der manipulative Gebrauch von Sprache entscheidend. Durch ihn sind sie in der Lage, die ›gefühlte‹ Wahrheit im Kampf gegen Fakten siegen zu lassen und Diskurse wie die Klima-Debatte oder die Diskussionen um Maßnahmen gegen die Coronapandemie zu beeinflussen.
Die Arbeit macht aber auch deutlich, wie kompliziert das Vorhaben der Polarisierung in einer heterogenen Gesellschaft wie der heutigen deutschen ist. Sogar innerhalb der AfD kommt es immer häufiger zu Uneinigkeiten.
Compound weather events may lead to extreme impacts that can affect many aspects of society including agriculture. Identifying the underlying mechanisms that cause extreme impacts, such as crop failure, is of crucial importance to improve their understanding and forecasting. In this study, we investigate whether key meteorological drivers of extreme impacts can be identified using the least absolute shrinkage and selection operator (LASSO) in a model environment, a method that allows for automated variable selection and is able to handle collinearity between variables. As an example of an extreme impact, we investigate crop failure using annual wheat yield as simulated by the Agricultural Production Systems sIMulator (APSIM) crop model driven by 1600 years of daily weather data from a global climate model (EC-Earth) under present-day conditions for the Northern Hemisphere. We then apply LASSO logistic regression to determine which weather conditions during the growing season lead to crop failure. We obtain good model performance in central Europe and the eastern half of the United States, while crop failure years in regions in Asia and the western half of the United States are less accurately predicted. Model performance correlates strongly with annual mean and variability of crop yields; that is, model performance is highest in regions with relatively large annual crop yield mean and variability. Overall, for nearly all grid points, the inclusion of temperature, precipitation and vapour pressure deficit is key to predict crop failure. In addition, meteorological predictors during all seasons are required for a good prediction. These results illustrate the omnipresence of compounding effects of both meteorological drivers and different periods of the growing season for creating crop failure events. Especially vapour pressure deficit and climate extreme indicators such as diurnal temperature range and the number of frost days are selected by the statistical model as relevant predictors for crop failure at most grid points, underlining their overarching relevance. We conclude that the LASSO regression model is a useful tool to automatically detect compound drivers of extreme impacts and could be applied to other weather impacts such as wildfires or floods. As the detected relationships are of purely correlative nature, more detailed analyses are required to establish the causal structure between drivers and impacts.
The co-occurrence of warm spells and droughts can lead to detrimental socio-economic and ecological impacts, largely surpassing the impacts of either warm spells or droughts alone. We quantify changes in the number of compound warm spells and droughts from 1979 to 2018 in the Mediterranean Basin using the ERA5 data set. We analyse two types of compound events: 1) warm season compound events, which are extreme in absolute terms in the warm season from May to October and 2) year-round deseasonalised compound events, which are extreme in relative terms respective to the time of the year. The number of compound events increases significantly and especially warm spells are increasing strongly – with an annual growth rates of 3.9 (3.5) % for warm season (deseasonalised) compound events and 4.6 (4.4) % for warm spells –, whereas for droughts the change is more ambiguous depending on the applied definition. Therefore, the rise in the number of compound events is primarily driven by temperature changes and not the lack of precipitation. The months July and August show the highest increases in warm season compound events, whereas the highest increases of deseasonalised compound events occur in spring and early summer. This increase in deseasonalised compound events can potentially have a significant impact on the functioning of Mediterranean ecosystems as this is the peak phase of ecosystem productivity and a vital phenophase.
Precipitation forecasting has an important place in everyday life – during the day we may have tens of small talks discussing the likelihood that it will rain this evening or weekend. Should you take an umbrella for a walk? Or should you invite your friends for a barbecue? It will certainly depend on what your weather application shows.
While for years people were guided by the precipitation forecasts issued for a particular region or city several times a day, the widespread availability of weather radars allowed us to obtain forecasts at much higher spatiotemporal resolution of minutes in time and hundreds of meters in space. Hence, radar-based precipitation nowcasting, that is, very-short-range forecasting (typically up to 1–3 h), has become an essential technique, also in various professional application contexts, e.g., early warning, sewage control, or agriculture.
There are two major components comprising a system for precipitation nowcasting: radar-based precipitation estimates, and models to extrapolate that precipitation to the imminent future. While acknowledging the fundamental importance of radar-based precipitation retrieval for precipitation nowcasts, this thesis focuses only on the model development: the establishment of open and competitive benchmark models, the investigation of the potential of deep learning, and the development of procedures for nowcast errors diagnosis and isolation that can guide model development.
The present landscape of computational models for precipitation nowcasting still struggles with the availability of open software implementations that could serve as benchmarks for measuring progress. Focusing on this gap, we have developed and extensively benchmarked a stack of models based on different optical flow algorithms for the tracking step and a set of parsimonious extrapolation procedures based on image warping and advection. We demonstrate that these models provide skillful predictions comparable with or even superior to state-of-the-art operational software. We distribute the corresponding set of models as a software library, rainymotion, which is written in the Python programming language and openly available at GitHub (https://github.com/hydrogo/rainymotion). That way, the library acts as a tool for providing fast, open, and transparent solutions that could serve as a benchmark for further model development and hypothesis testing.
One of the promising directions for model development is to challenge the potential of deep learning – a subfield of machine learning that refers to artificial neural networks with deep architectures, which may consist of many computational layers. Deep learning showed promising results in many fields of computer science, such as image and speech recognition, or natural language processing, where it started to dramatically outperform reference methods.
The high benefit of using "big data" for training is among the main reasons for that. Hence, the emerging interest in deep learning in atmospheric sciences is also caused and concerted with the increasing availability of data – both observational and model-based. The large archives of weather radar data provide a solid basis for investigation of deep learning potential in precipitation nowcasting: one year of national 5-min composites for Germany comprises around 85 billion data points.
To this aim, we present RainNet, a deep convolutional neural network for radar-based precipitation nowcasting. RainNet was trained to predict continuous precipitation intensities at a lead time of 5 min, using several years of quality-controlled weather radar composites provided by the German Weather Service (DWD). That data set covers Germany with a spatial domain of 900 km x 900 km and has a resolution of 1 km in space and 5 min in time. Independent verification experiments were carried out on 11 summer precipitation events from 2016 to 2017. In these experiments, RainNet was applied recursively in order to achieve lead times of up to 1 h. In the verification experiments, trivial Eulerian persistence and a conventional model based on optical flow served as benchmarks. The latter is available in the previously developed rainymotion library.
RainNet significantly outperformed the benchmark models at all lead times up to 60 min for the routine verification metrics mean absolute error (MAE) and critical success index (CSI) at intensity thresholds of 0.125, 1, and 5 mm/h. However, rainymotion turned out to be superior in predicting the exceedance of higher intensity thresholds (here 10 and 15 mm/h). The limited ability of RainNet to predict high rainfall intensities is an undesirable property which we attribute to a high level of spatial smoothing introduced by the model. At a lead time of 5 min, an analysis of power spectral density confirmed a significant loss of spectral power at length scales of 16 km and below.
Obviously, RainNet had learned an optimal level of smoothing to produce a nowcast at 5 min lead time. In that sense, the loss of spectral power at small scales is informative, too, as it reflects the limits of predictability as a function of spatial scale. Beyond the lead time of 5 min, however, the increasing level of smoothing is a mere artifact – an analogue to numerical diffusion – that is not a property of RainNet itself but of its recursive application. In the context of early warning, the smoothing is particularly unfavorable since pronounced features of intense precipitation tend to get lost over longer lead times. Hence, we propose several options to address this issue in prospective research on model development for precipitation nowcasting, including an adjustment of the loss function for model training, model training for longer lead times, and the prediction of threshold exceedance.
The model development together with the verification experiments for both conventional and deep learning model predictions also revealed the need to better understand the source of forecast errors. Understanding the dominant sources of error in specific situations should help in guiding further model improvement. The total error of a precipitation nowcast consists of an error in the predicted location of a precipitation feature and an error in the change of precipitation intensity over lead time. So far, verification measures did not allow to isolate the location error, making it difficult to specifically improve nowcast models with regard to location prediction.
To fill this gap, we introduced a framework to directly quantify the location error. To that end, we detect and track scale-invariant precipitation features (corners) in radar images. We then consider these observed tracks as the true reference in order to evaluate the performance (or, inversely, the error) of any model that aims to predict the future location of a precipitation feature. Hence, the location error of a forecast at any lead time ahead of the forecast time corresponds to the Euclidean distance between the observed and the predicted feature location at the corresponding lead time.
Based on this framework, we carried out a benchmarking case study using one year worth of weather radar composites of the DWD. We evaluated the performance of four extrapolation models, two of which are based on the linear extrapolation of corner motion; and the remaining two are based on the Dense Inverse Search (DIS) method: motion vectors obtained from DIS are used to predict feature locations by linear and Semi-Lagrangian extrapolation.
For all competing models, the mean location error exceeds a distance of 5 km after 60 min, and 10 km after 110 min. At least 25% of all forecasts exceed an error of 5 km after 50 min, and of 10 km after 90 min. Even for the best models in our experiment, at least 5 percent of the forecasts will have a location error of more than 10 km after 45 min. When we relate such errors to application scenarios that are typically suggested for precipitation nowcasting, e.g., early warning, it becomes obvious that location errors matter: the order of magnitude of these errors is about the same as the typical extent of a convective cell. Hence, the uncertainty of precipitation nowcasts at such length scales – just as a result of locational errors – can be substantial already at lead times of less than 1 h. Being able to quantify the location error should hence guide any model development that is targeted towards its minimization. To that aim, we also consider the high potential of using deep learning architectures specific to the assimilation of sequential (track) data.
Last but not least, the thesis demonstrates the benefits of a general movement towards open science for model development in the field of precipitation nowcasting. All the presented models and frameworks are distributed as open repositories, thus enhancing transparency and reproducibility of the methodological approach. Furthermore, they are readily available to be used for further research studies, as well as for practical applications.
Mit 52 Texten versammelt diese Dokumentation sämtliche uns heute bekannten Rezensionen zu Theodor Fontanes „Der Krieg gegen Frankreich 1870–1871“, das in zwei Bänden, bestehend aus insgesamt vier Halbbänden, zwischen März 1873 und September 1876 im Verlag der Königlichen Geheimen Ober-Hofbuchdruckerei (R. v. Decker) erschien. Der Text der Rezensionen wird jeweils nach dem Erstdruck in Zeitungen oder Zeitschriften zeichengetreu konstituiert. Damit wird der Forschung zu Fontanes Darstellung über den Deutsch-Französischen Krieg erstmals eine wichtige rezeptionsgeschichtliche Materialgruppe als Ausgabe zur Verfügung gestellt.
Einleitung
Ältere Patienten mit Herzklappenerkrankungen werden zunehmend häufig mit der kathetergestützten Aortenklappenimplantation (Transcatheter Aortic Valve Implantation, TAVI) oder dem MitraClip®-Verfahren behandelt. In der kardiologischen Rehabilitation nimmt infolgedessen die Patientenpopulation der Hochbetagten stetig zu. Die funktionale Gesundheit dieser Patienten wird durch häufig auftretende, sogenannte geriatrische Syndrome wie Multimorbidität, Mangelernährung, Gebrechlichkeit oder Sturzereignisse beeinflusst. Insbesondere die eingeschränkte Mobilität und Mangelernährung sind wichtige Prädiktoren für die Prognose der Patienten nach TAVI.
Etablierte Verfahren, um die körperliche Leistungsfähigkeit von kardiologischen Rehabilitanden zu beurteilen, sind die Belastungsergometrie und der 6-Minuten-Gehtest. Allerdings ist nahezu die Hälfte der hochbetagten Patienten nicht in der Lage, eine Belastungsergometrie durchzuführen. Bislang erfolgt in der kardiologischen Rehabilitation keine differenzierte Erfassung des funktionellen Status hinsichtlich Mobilität, Kraft und Gleichgewicht, um die geriatrischen Syndrome individuell zu beurteilen. Darüber hinaus werden keine Assessments zur Erfassung des Ernährungsstatus eingesetzt.
Daher war es das Ziel der vorliegenden Arbeit, die Ausprägung des funktionellen und nutritiven Status älterer Patienten anhand geeigneter Assessments in der kardiologischen Rehabilitation zu ermitteln.
Methode
Zwischen Oktober 2018 und Juni 2019 nahmen Patienten im Alter von 75 Jahren oder älter nach TAVI, atrioventrikulärer Intervention mittels MitraClip®-Verfahren (AVI) oder perkutaner Koronarintervention (PCI) an der Studie teil. Zu Beginn der kardiologischen Rehabilitation wurden soziodemografische Daten, echokardiografische Parameter (z. B. links und rechtsventrikuläre Ejektionsfraktion, Herzrhythmus) und Komorbiditäten (z. B. Diabetes mellitus, Niereninsuffizienz, orthopädische Erkrankungen) erhoben, um die Patientenpopulation zu beschreiben. Zusätzlich wurde die Gebrechlichkeit der Rehabilitanden mit dem Index von Stortecky et al., bestehend aus den Komponenten Kognition, Mobilität, Ernährung und Aktivitäten des täglichen Lebens, beurteilt.
Der 6-Minuten-Gehtest diente zur Ermittlung der körperlichen Leistungsfähigkeit der Patienten. Die Mobilität wurde mit Hilfe des Timed-Up-and-Go-Tests, die Ganggeschwindigkeit mit dem Gait Speed Test und die Handkraft mit dem Hand Grip Test erfasst.
Für die Objektivierung des Gleichgewichts wurde eine Kraftmessplatte (uni- und bipedaler Stand mit geöffneten und geschlossenen Augen) erprobt, die bislang bei älteren Rehabilitanden noch nicht eingesetzt wurde.
Der Ernährungsstatus wurde mit dem Mini Nutritional Assessment-Short Form und den ernährungsbezogenen Laborparametern (Hämoglobin, Serumalbumin, Eiweißkonzentration) erfasst.
Die Eignung der Assessments bewerteten wir anhand folgender Kriterien: Durchführbarkeit (bei ≥ 95 % der Patienten durchführbar), Sicherheit (< 95 % Stürze oder andere unerwünschte Ereignisse) und der Pearson-Korrelationen zwischen den funktionellen Tests und dem Goldstandard 6-Minuten-Gehtest sowie den Laborparametern und dem Mini Nutritional Assessment-Short Form.
Ergebnisse
Es wurden 124 Patienten (82 ± 4 Jahre, 48 % Frauen, 5 ± 2 Komorbiditäten, 9 ± 3 Medikamente) nach TAVI (n = 59), AVI (n = 21) und PCI (n = 44) konsekutiv in die Studie eingeschlossen.
Etwa zwei Drittel aller Patienten der Gesamtpopulation waren als gebrechlich zu klassifizieren, bei einer mittleren Punktzahl von 2,9 ± 1,4. Annähernd die Hälfte der Patienten zeigte eine eingeschränkte körperliche Leistungsfähigkeit aufgrund einer reduzierten 6-Minuten-Gehstrecke (48 % < 350 m) sowie eine eingeschränkte Mobilität im Timed-Up-and-Go-Test (55 % > 10 s). Es wurden eine mittlere Gehstrecke von 339 ± 131 m und eine durchschnittliche Zeit im Timed-Up-and-Go-Test von 11,4 ± 6,3 s erzielt. Darüber hinaus wies ein Viertel der Patienten eine eingeschränkte Ganggeschwindigkeit (< 0,8 m/s) auf und etwa 35 % von Ihnen zeigten eine reduzierte Handkraft (Frauen/Männer < 16/27 kg). Im Mittel wurde eine Geschwindigkeit von 1,0 ± 0,2 m/s im Gait Speed Test sowie eine Handkraft von 24 ± 9 kg im Hand Grip Test erreicht. Ein Risiko einer Mangelernährung konnte bei 38 % (< 12 Punkte) der Patienten nachgewiesen werden bei einer mittleren Punktzahl von 11,8 ± 2,2 im Mini Nutritional Assessment-Short Form.
Im Vergleich zwischen den einzelnen Subpopulationen bestanden keine statistisch signifikanten Unterschiede in den Ergebnissen der funktionellen Assessments. Bezüglich des Ernährungsstatus wiesen allerdings die Patienten nach AVI einen statistisch signifikant niedrigeren Punktewert im Mini Nutritional Assessment-Short Form (10,3 ± 3,0 Punkte) auf als die Patienten nach TAVI (12,0 ± 1,8 Punkte) und PCI (12,1 ± 2,1 Punkte), wobei etwa 57 % der Patienten nach AVI, 38 % nach TAVI und 50 % nach PCI ein Risiko einer Mangelernährung zeigten.
Mit Ausnahme der Tests auf der Kraftmessplatte waren alle Assessments durchführbar und sicher. Während 86 % der Patienten den bipedalen Stand mit geschlossenen Augen auf der Kraftmessplatte durchführen konnten und damit nahezu den Grenzwert von 95 % erreichten, war der unipedale Stand mit 12 % an durchführbaren Messungen weit von diesem entfernt.
Der Gait Speed Test (r = 0,79), Timed-Up-and-Go-Test (r = 0,68) und Hand Grip Test (r = 0,33) korrelierten signifikant mit dem 6-Minuten-Gehtest, Hämoglobin (r = 0,20) und Albumin (r = 0,24) korrelierten mit dem Mini Nutritional Assessment-Short Form.
Schlussfolgerung
Über die bestehende Multimorbidität und Multimedikation hinaus wiesen die untersuchten Patienten vor allem eine eingeschränkte Mobilität und ein Risiko einer Mangelernährung auf, wobei die Subpopulation nach AVI besonders betroffen war.
Um den Bedürfnissen hochbetagter Rehabilitanden nach kathetergestützer Intervention gerecht zu werden, ist eine individuelle Behandlung der einzelnen Defizite erforderlich, mit besonderer Berücksichtigung der Komorbiditäten sowie der geriatrischen Kofaktoren. Aufgrund des multidisziplinären Ansatzes erfüllt die kardiologische Rehabilitation bereits die Voraussetzung, hochbetagte Patienten bedarfsgerecht zu behandeln, jedoch mangelt es an Assessments, um die individuellen Defizite der Patienten zu identifizieren
Der Gait Speed Test, der Timed-Up-and-Go-Test und der Hand Grip Test sollten daher in den klinischen Alltag der kardiologischen Rehabilitation implementiert werden, um die körperliche Funktion und Leistungsfähigkeit älterer Patienten detailliert zu beurteilen. In Kombination dieser Assessments mit dem Mini Nutritional Assessment-Short Form können die individuellen funktionellen und nutritiven Bedürfnisse der Patienten während der Rehabilitation erkannt und mit geeigneten Maßnahmen die weitere Ausbildung geriatrischer Syndrome gemindert werden.
The prevalence of diseases associated with misfolded proteins increases with age. When cellular defense mechanisms become limited, misfolded proteins form aggregates and may also develop more stable cross-β structures ultimately forming amyloid aggregates. Amyloid aggregates are associated with neurodegenerative diseases such as Alzheimer’s disease and Huntington’s disease. The formation of amyloid deposits, their toxicity and cellular defense mechanisms have been intensively studied. However, surprisingly little is known about the effects of protein aggregates on cellular signal transduction. It is also not understood whether the presence of aggregation-prone, but still soluble proteins affect signal transduction.
In this study, the still soluble aggregation-prone HttExon1Q74 and its amyloid aggregates were used to analyze the effect of amyloid aggregates on internalization and receptor activation of G protein-coupled receptors (GPCRs), the largest protein family of mammalian cell surface receptors involved in signal transduction. The aggregated HttExon1Q74, but not its soluble form, could inhibit ligand-induced clathrin-mediated endocytosis (CME) of various GPCRs. Most likely this inhibitory effect is based on a terminal sequestration of the HSC70 chaperone to the aggregates which is necessary for CME. Using the vasopressinV1a receptor (V1aR) and the corticotropin-releasing factor receptor 1 (CRF1R) as a model, it could be shown that the presence of HttExon1Q74 aggregates and the inhibition of ligand-induced CME leads to an accumulation of desensitized receptors at the plasma membrane. In turn, this disrupts Gq-mediated Ca2+ signaling and Gs-mediated cAMP signaling of the V1aR and the CRF1R respectively. In contrast to HttExon1Q74 amyloid aggregates, soluble HttExon1Q74 as well as amorphous aggregates did not inhibit GPCR internalization and signaling demonstrating that cellular signal transduction mechanisms are specifically impaired in response to the formation of amyloid aggregates.
In addition, preliminary experiments could show that HttExon1Q74 aggregates provoke an increase in membrane expression of a protein from a structurally and functionally unrelated membrane protein family, namely the serotonin transporter SERT. As SERT is the main pharmacological target to treat depression this could shed light on this commonly occurring comorbidity in neurodegenerative diseases, in particular in early disease states.
We use ultrafast x-ray diffraction to investigate the effect of expansive phononic and contractive magnetic stress driving the picosecond strain response of a metallic perovskite SrRuO3 thin film upon femtosecond laser excitation. We exemplify how the anisotropic bulk equilibrium thermal expansion can be used to predict the response of the thin film to ultrafast deposition of energy. It is key to consider that the laterally homogeneous laser excitation changes the strain response compared to the near-equilibrium thermal expansion because the balanced in-plane stresses suppress the Poisson stress on the picosecond timescale. We find a very large negative Grüneisen constant describing the large contractive stress imposed by a small amount of energy in the spin system. The temperature and fluence dependence of the strain response for a double-pulse excitation scheme demonstrates the saturation of the magnetic stress in the high-fluence regime.
Die Vielfältigkeit des Winkelbegriffs ist gleichermaßen spannend wie herausfordernd in Hinblick auf seine Zugänge im Mathematikunterricht der Schule. Ausgehend von verschiedenen Vorstellungen zum Winkelbegriff wird in dieser Arbeit ein Lehrgang zur Vermittlung des Winkelbegriffs entwickelt und letztlich in konkrete Umsetzungen für den Schulunterricht überführt.
Dabei erfolgt zunächst eine stoffdidaktische Auseinandersetzung mit dem Winkelbegriff, die von einer informationstheoretischen Winkeldefinition begleitet wird. In dieser wird eine Definition für den Winkelbegriff unter der Fragestellung entwickelt, welche Informationen man über einen Winkel benötigt, um ihn beschreiben zu können. So können die in der fachdidaktischen Literatur auftretenden Winkelvorstellungen aus fachmathematischer Perspektive erneut abgeleitet und validiert werden. Parallel dazu wird ein Verfahren beschrieben, wie Winkel – auch unter dynamischen Aspekten – informationstechnisch verarbeitet werden können, so dass Schlussfolgerungen aus der informationstheoretischen Winkeldefinition beispielsweise in dynamischen Geometriesystemen zur Verfügung stehen.
Unter dem Gesichtspunkt, wie eine Abstraktion des Winkelbegriffs im Mathematikunterricht vonstatten gehen kann, werden die Grundvorstellungsidee sowie die Lehrstrategie des Aufsteigens vom Abstrakten zum Konkreten miteinander in Beziehung gesetzt. Aus der Verknüpfung der beiden Theorien wird ein grundsätzlicher Weg abgeleitet, wie im Rahmen der Lehrstrategie eine Ausgangsabstraktion zu einzelnen Winkelaspekten aufgebaut werden kann, was die Generierung von Grundvorstellungen zu den Bestandteilen des jeweiligen Winkelaspekts und zum Operieren mit diesen Begriffsbestandteilen ermöglichen soll. Hierfür wird die Lehrstrategie angepasst, um insbesondere den Übergang von Winkelsituationen zu Winkelkontexten zu realisieren. Explizit für den Aspekt des Winkelfeldes werden, anhand der Untersuchung der Sichtfelder von Tieren, Lernhandlungen und Forderungen an ein Lernmodell beschrieben, die Schülerinnen und Schüler bei der Begriffsaneignung unterstützen.
Die Tätigkeitstheorie, der die genannte Lehrstrategie zuzuordnen ist, zieht sich als roter Faden durch die weitere Arbeit, wenn nun theoriebasiert Designprinzipien generiert werden, die in die Entwicklung einer interaktiven Lernumgebung münden. Hierzu wird u. a. das Modell der Artifact-Centric Activity Theory genutzt, das das Beziehungsgefüge aus Schülerinnen und Schülern, dem mathematischen Gegenstand und einer zu entwickelnden App als vermittelndes Medium beschreibt, wobei der Einsatz der App im Unterrichtskontext sowie deren regelgeleitete Entwicklung Bestandteil des Modells sind. Gemäß dem Ansatz der Fachdidaktischen Entwicklungsforschung wird die Lernumgebung anschließend in mehreren Zyklen erprobt, evaluiert und überarbeitet. Dabei wird ein qualitatives Setting angewandt, das sich der Semiotischen Vermittlung bedient und untersucht, inwiefern sich die Qualität der von den Schülerinnen und Schülern gezeigten Lernhandlungen durch die Designprinzipien und deren Umsetzung erklären lässt. Am Ende der Arbeit stehen eine finale Version der Designprinzipien und eine sich daraus ergebende Lernumgebung zur Einführung des Winkelfeldbegriffs in der vierten Klassenstufe.
Conceptual knowledge about objects, people and events in the world is central to human cognition, underlying core cognitive abilities such as object recognition and use, and word comprehension. Previous research indicates that concepts consist of perceptual and motor features represented in modality-specific perceptual-motor brain regions. In addition, cross-modal convergence zones integrate modality-specific features into more abstract conceptual representations.
However, several questions remain open: First, to what extent does the retrieval of perceptual-motor features depend on the concurrent task? Second, how do modality-specific and cross-modal regions interact during conceptual knowledge retrieval? Third, which brain regions are causally relevant for conceptually-guided behavior? This thesis addresses these three key issues using functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) in the healthy human brain.
Study 1 - an fMRI activation study - tested to what extent the retrieval of sound and action features of concepts, and the resulting engagement of auditory and somatomotor brain regions depend on the concurrent task. 40 healthy human participants performed three different tasks - lexical decision, sound judgment, and action judgment - on words with a high or low association to sounds and actions. We found that modality-specific regions selectively respond to task-relevant features: Auditory regions selectively responded to sound features during sound judgments, and somatomotor regions selectively responded to action features during action judgments. Unexpectedly, several regions (e.g. the left posterior parietal cortex; PPC) exhibited a task-dependent response to both sound and action features. We propose these regions to be "multimodal", and not "amodal", convergence zones which retain modality-specific information.
Study 2 - an fMRI connectivity study - investigated the functional interaction between modality-specific and multimodal areas during conceptual knowledge retrieval. Using the above fMRI data, we asked (1) whether modality-specific and multimodal regions are functionally coupled during sound and action feature retrieval, (2) whether their coupling depends on the task, (3) whether information flows bottom-up, top-down, or bidirectionally, and (4) whether their coupling is behaviorally relevant. We found that functional coupling between multimodal and modality-specific areas is task-dependent, bidirectional, and relevant for conceptually-guided behavior. Left PPC acted as a connectivity "switchboard" that flexibly adapted its coupling to task-relevant modality-specific nodes.
Hence, neuroimaging studies 1 and 2 suggested a key role of left PPC as a multimodal convergence zone for conceptual knowledge. However, as neuroimaging is correlational, it remained unknown whether left PPC plays a causal role as a multimodal conceptual hub. Therefore, study 3 - a TMS study - tested the causal relevance of left PPC for sound and action feature retrieval. We found that TMS over left PPC selectively impaired action judgments on low sound-low action words, as compared to sham stimulation. Computational simulations of the TMS-induced electrical field revealed that stronger stimulation of left PPC was associated with worse performance on action, but not sound, judgments. These results indicate that left PPC causally supports conceptual processing when action knowledge is task-relevant and cannot be compensated by sound knowledge. Our findings suggest that left PPC is specialized for action knowledge, challenging the view of left PPC as a multimodal conceptual hub.
Overall, our studies support "hybrid theories" which posit that conceptual processing involves both modality-specific perceptual-motor regions and cross-modal convergence zones. In our new model of the conceptual system, we propose conceptual processing to rely on a representational hierarchy from modality-specific to multimodal up to amodal brain regions. Crucially, this hierarchical system is flexible, with different regions and connections being engaged in a task-dependent fashion. Our model not only reconciles the seemingly opposing grounded cognition and amodal theories, it also incorporates task dependency of conceptually-related brain activity and connectivity, thereby resolving several current issues on the neural basis of conceptual knowledge retrieval.
This paper-based dissertation aims to contribute to the open innovation (OI) and technology management (TM) research fields by investigating their mechanisms, and potentials at the operational level. The dissertation connects the well-known concept of technology management with OI formats and applies these on specific manufacturing technologies within a clearly defined setting.
Technological breakthroughs force firms to continuously adapt and reinvent themselves. The pace of technological innovation and their impact on firms is constantly increasing due to more connected infrastructure and accessible resources (i.e. data, knowledge). Especially in the manufacturing sector it is one key element to leverage new technologies to stay competitive. These technological shifts call for new management practices.
TM supports firms with various tools to manage these shifts at different levels in the firm. It is a multifunctional and multidisciplinary field as it deals with all aspects of integrating technological issues into business decision-making and is directly relevant to a number of core business processes. Thus, it makes sense to utilize this theory and their practices as a foundation of this dissertation. However, considering the increasing complexity and number of technologies it is not sufficient anymore for firms to only rely on previous internal R&D and managerial practices. OI can expanse these practices by involving distributed innovation processes and accessing further external knowledge sources. This expansion can lead to an increasing innovation performance and thereby accelerate the time-to-market of technologies.
Research in this dissertation was based on the expectations that OI formats will support the R&D activities of manufacturing technologies on the operational level by providing access to resources, knowledge, and leading-edge technology. The dissertation represents uniqueness regarding the rich practical data sets (observations, internal documents, project reviews) drawn from a very large German high-tech firm. The researcher was embedded in an R&D unit within the operational TM department for manufacturing technologies. The analyses include 1.) an exploratory in-depth analysis of a crowdsourcing initiative to elaborate the impact on specific manufacturing technologies, 2.) a deductive approach for developing a technology evaluation score model to create a common understanding of the value of selected manufacturing technologies at the operational level, and 3.) an abductive reasoning approach in form of a longitudinal case study to derive important indicator for the in-process activities of science-based partnership university-industry collaboration format. Thereby, the dissertation contributed to research and practice 1.) linkages of TM and OI practices to assimilate technologies at the operational level, 2.) insights about the impact of CS on manufacturing technologies and a related guideline to execute CS initiatives in this specific environment 3.) introduction of manufacturing readiness levels and further criteria into the TM and OI research field to support decision-makers in the firm in gaining a common understanding of the maturity of manufacturing technologies and, 4.) context-specific important indicators for science based university-industry collaboration projects and a holistic framework to connect TM with the university-industry collaboration approach
The findings of this dissertation illustrate that OI formats can support the acceleration of time-to-market of manufacturing technologies and further improve the technical requirements of the product by leveraging external capabilities. The conclusions and implications made are intended to foster further research and improve managerial practices to evolve TM into an open collaborative context with interconnectivities between all internal and external involved technologies, individuals and organizational levels.
Anthropogenic climate change alters the hydrological cycle. While certain areas experience more intense precipitation events, others will experience droughts and increased evaporation, affecting water storage in long-term reservoirs, groundwater, snow, and glaciers. High elevation environments are especially vulnerable to climate change, which will impact the water supply for people living downstream. The Himalaya has been identified as a particularly vulnerable system, with nearly one billion people depending on the runoff in this system as their main water resource. As such, a more refined understanding of spatial and temporal changes in the water cycle in high altitude systems is essential to assess variations in water budgets under different climate change scenarios.
However, not only anthropogenic influences have an impact on the hydrological cycle, but changes to the hydrological cycle can occur over geological timescales, which are connected to the interplay between orogenic uplift and climate change. However, their temporal evolution and causes are often difficult to constrain. Using proxies that reflect hydrological changes with an increase in elevation, we can unravel the history of orogenic uplift in mountain ranges and its effect on the climate.
In this thesis, stable isotope ratios (expressed as δ2H and δ18O values) of meteoric waters and organic material are combined as tracers of atmospheric and hydrologic processes with remote sensing products to better understand water sources in the Himalayas. In addition, the record of modern climatological conditions based on the compound specific stable isotopes of leaf waxes (δ2Hwax) and brGDGTs (branched Glycerol dialkyl glycerol tetraethers) in modern soils in four Himalayan river catchments was assessed as proxies of the paleoclimate and (paleo-) elevation. Ultimately, hydrological variations over geological timescales were examined using δ13C and δ18O values of soil carbonates and bulk organic matter originating from sedimentological sections from the pre-Siwalik and Siwalik groups to track the response of vegetation and monsoon intensity and seasonality on a timescale of 20 Myr.
I find that Rayleigh distillation, with an ISM moisture source, mainly controls the isotopic composition of surface waters in the studied Himalayan catchments. An increase in d-excess in the spring, verified by remote sensing data products, shows the significant impact of runoff from snow-covered and glaciated areas on the surface water isotopic values in the timeseries.
In addition, I show that biomarker records such as brGDGTs and δ2Hwax have the potential to record (paleo-) elevation by yielding a significant correlation with the temperature and surface water δ2H values, respectively, as well as with elevation. Comparing the elevation inferred from both brGDGT and δ2Hwax, large differences were found in arid sections of the elevation transects due to an additional effect of evapotranspiration on δ2Hwax. A combined study of these proxies can improve paleoelevation estimates and provide recommendations based on the results found in this study.
Ultimately, I infer that the expansion of C4 vegetation between 20 and 1 Myr was not solely dependent on atmospheric pCO2, but also on regional changes in aridity and seasonality from to the stable isotopic signature of the two sedimentary sections in the Himalaya (east and west).
This thesis shows that the stable isotope chemistry of surface waters can be applied as a tool to monitor the changing Himalayan water budget under projected increasing temperatures. Minimizing the uncertainties associated with the paleo-elevation reconstructions were assessed by the combination of organic proxies (δ2Hwax and brGDGTs) in Himalayan soil. Stable isotope ratios in bulk soil and soil carbonates showed the evolution of vegetation influenced by the monsoon during the late Miocene, proving that these proxies can be used to record monsoon intensity, seasonality, and the response of vegetation. In conclusion, the use of organic proxies and stable isotope chemistry in the Himalayas has proven to successfully record changes in climate with increasing elevation. The combination of δ2Hwax and brGDGTs as a new proxy provides a more refined understanding of (paleo-)elevation and the influence of climate.
Die vorliegende Dissertation behandelt drei thematische Schwerpunkte. Im Ergebnisteil steht die chemische Synthese von sogenannten (1,7)-Naphthalenophanen im Vordergrund, die zur Substanzklasse von Cyclophanen gehören. Während zahlreiche Synthesemethoden Strategien zum Aufbau von Ringsystemen (wie z. B. von Naphthalenophanen) verfolgen, die Teil einer bereits existierenden aromatischen Struktur der Ausgangsverbindung sind, nutzen nur wenige Ansätze Reaktionen, die einen Ringschluss zum gewünschten Produkt erst im Zuge der Synthese etablieren. Eine Benzanellierung, die eine besondere Aufmerksamkeit im Arbeitskreis erfahren hat, ist die Dehydro-DIELS-ALDER-Reaktion (DDA-Reaktion). Im Rahmen dieser Arbeit konnte gezeigt werden, dass zwölf ausgewählte (1,7)-Naphthalenophane, die teilweise ringgespannt und makrozyklisch aufgebaut waren, mithilfe einer photochemischen Variante der DDA-Reaktion (PDDA-Reaktion) zugänglich gemacht werden können. Die Versuche, auf thermischem Wege (TDDA-Reaktion) (1,7)-Naphthalenophane herzustellen, misslangen. Die außergewöhnliche Reaktivität der Photoreaktanten konnte mithilfe quantenchemischer Berechnungen durch eine gefaltete Grundzustandsgeometrie erklärt werden. Darüber hinaus wurden Ringspannungen und strukturelle Spannungsindikatoren der relevanten Photoprodukte ermittelt und Trends in Abhängigkeit der Linkerlänge in den NMR-Spektren der Zielverbindungen ermittelt sowie diskutiert. Zudem zeigte eine Variation am Chromophor (Acyl-, Carbonsäure- und Carbonsäureester) der Photoreaktanten bei der Bestrahlung in Dichlormethan eine vergleichbare Photokinetik und -reaktivität. Der zweite Abschnitt dieser Dissertation ist dem Design und der Entwicklung zweier Photoreaktoren für UV-Anwendungen im kontinuierlichen Durchfluss gewidmet, da photochemische Transformationen bekanntermaßen in ihrer Skalierbarkeit limitiert sind. Im ersten Prototyp konnten mittels effizienter Parallelschaltung mit bis zu drei UV-Lampen (𝜆𝜆 = 254, 310 und 355 nm) Produktmaterialmengen von bis zu n = 188 mmol anhand eines ausgewählten Fallbeispiels erreicht werden. Im konstruktionstechnisch stark vereinfachten zweiten Photoreaktor wurden alle quarzhaltigen Elemente gegen günstigeres PLEXIGLAS® ersetzt. Das Resultat waren identische Raum-Zeit-Ausbeuten in Bezug auf das zuvor gewählte Synthesebeispiel. Demnach bietet die UV-Photochemie im kontinuierlichen Durchfluss Vorteile gegenüber der traditionellen Bestrahlung im Tauchreaktor. Hinsichtlich Reaktionszeit, Produktausbeuten und Lösemittelverbrauch ist sie synthetisch weit überlegen. Im letzten Abschnitt der Arbeit wurden diese Erkenntnisse genutzt, um biomedizinisch und pharmakologisch vielversprechende 1-Arylnaphthalen-Lignane mittels einer intramolekularen PDDA-Reaktion (IMPDDA-Reaktion) als Schlüsselschritt herzustellen. Hierzu wurden drei Konzepte erarbeitet und in der Totalsynthese von drei ausgewählten Zielstrukturen auf Basis des 1-Arylnaphthalengrundgerüsts realisiert.
Fluids in the Earth's crust can move by creating and flowing through fractures, in a process called `hydraulic fracturing’. The tip-line of such fluid-filled fractures grows at locations where stress is larger than the strength of the rock. Where the tip stress vanishes, the fracture closes and the fluid-front retreats. If stress gradients exist on the fracture's walls, induced by fluid/rock density contrasts or topographic stresses, this results in an asymmetric shape and growth of the fracture, allowing for the contained batch of fluid to propagate through the crust.
The state-of-the-art analytical and numerical methods to simulate fluid-filled fracture propagation are two-dimensional (2D). In this work I extend these to three dimensions (3D). In my analytical method, I approximate the propagating 3D fracture as a penny-shaped crack that is influenced by both an internal pressure and stress gradients. In addition, I develop a numerical method to model propagation where curved fractures can be simulated as a mesh of triangular dislocations, with the displacement of faces computed using the displacement discontinuity method. I devise a rapid technique to approximate stress intensity and use this to calculate the advance of the tip-line. My 3D models can be applied to arbitrary stresses, topographic and crack shapes, whilst retaining short computation times.
I cross-validate my analytical and numerical methods and apply them to various natural and man-made settings, to gain additional insights into the movements of hydraulic fractures such as magmatic dikes and fluid injections in rock. In particular, I calculate the `volumetric tipping point’, which once exceeded allows a fluid-filled fracture to propagate in a `self-sustaining’ manner. I discuss implications this has for hydro-fracturing in industrial operations. I also present two studies combining physical models that define fluid-filled fracture trajectories and Bayesian statistical techniques. In these studies I show that the stress history of the volcanic edifice defines the location of eruptive vents at volcanoes. Retrieval of the ratio between topographic to remote stresses allows for forecasting of probable future vent locations. Finally, I address the mechanics of 3D propagating dykes and sills in volcanic regions. I focus on Sierra Negra volcano in the Gal\'apagos islands, where in 2018, a large sill propagated with an extremely curved trajectory. Using a 3D analysis, I find that shallow horizontal intrusions are highly sensitive to topographic and buoyancy stress gradients, as well as the effects of the free surface.
The mitochondrial chaperone complex HSP60/HSP10 facilitates mitochondrial protein homeostasis by folding more than 300 mitochondrial matrix proteins. It has been shown previously that HSP60 is downregulated in brains of type 2 diabetic (T2D) mice and patients,
causing mitochondrial dysfunction and insulin resistance. As HSP60 is also decreased in peripheral tissues in T2D animals, this thesis investigated the effect of overall reduced HSP60 in the development of obesity and associated co-morbidities.
To this end, both female and male C57Bl/6N control (i.e. without further alterations in their genome, Ctrl) and heterozygous whole-body Hsp60 knock-out (Hsp60+/-) mice, which exhibit a 50 % reduction of HSP60 in all tissues, were fed a normal chow diet (NCD) or a highfat diet (HFD, 60 % calories from fat) for 16 weeks and were subjected to extensive metabolic phenotyping including indirect calorimetry, NMR spectroscopy, insulin, glucose and pyruvate tolerance tests, vena cava insulin injections, as well as histological and molecular analysis.
Interestingly, NCD feeding did not result in any striking phenotype, only a mild increase in energy expenditure in Hsp60+/- mice. Exposing mice to a HFD however revealed an increased body weight due to higher muscle mass in female Hsp60+/- mice, with a simultaneous decrease in energy expenditure. Additionally, these mice displayed decreased fasting glycemia. Opposingly, male Hsp60+/- compared to control mice showed lower body weight gain due to decreased fat mass and an increased energy expenditure, strikingly independent of lean mass. Further, only male Hsp60+/- mice display improved HOMA-IR and Matsuda
insulin sensitivity indices.
Despite the opposite phenotype in regards to body weight development, Hsp60+/- mice of both sexes show a significantly higher cell number, as well as a reduction in adipocyte size in the subcutaneous and gonadal white adipose tissue (sc/gWAT). Curiously, this adipocyte hyperplasia – usually associated with positive aspects of WAT function – is disconnected from metabolic improvements, as the gWAT of male Hsp60+/- mice shows mitochondrial dysfunction, oxidative stress, and insulin resistance. Transcriptomic analysis of gWAT shows an up
regulation of genes involved in macroautophagy. Confirmatory, expression of microtubuleassociated protein 1A/1B light chain 3B (LC3), as a protein marker of autophagy, and direct measurement of lysosomal activity is increased in the gWAT of male Hsp60+/- mice.
In summary, this thesis revealed a novel gene-nutrient interaction. The reduction of the crucial chaperone HSP60 did not have large effects in mice fed a NCD, but impacted metabolism during DIO in a sex-specific manner, where, despite opposing body weight and
body composition phenotypes, both female and male Hsp60+/- mice show signs of protection from high fat diet-induced systemic insulin resistance.
The High Energy Stereoscopic System (H.E.S.S.) is an array of five imaging atmospheric Cherenkov telescopes located in the Khomas Highland of Namibia. H.E.S.S. operates in a wide energy range from several tens of GeV to several tens of TeV, reaching the best sensitivity around 1 TeV or at lower energies. However, there are many important topics – such as the search for Galactic PeVatrons, the study of gamma-ray production scenarios for sources (hadronic vs. leptonic), EBL absorption studies – which require good sensitivity at energies above 10 TeV. This work aims at improving the sensitivity of H.E.S.S. and increasing the gamma-ray statistics at high energies. The study investigates an enlargement of the H.E.S.S. effective field of view using events with larger offset angles in the analysis. The greatest challenges in the analysis of large-offset events are a degradation of the reconstruction accuracy and a rise of the background rate as the offset angle increases. The more sophisticated direction reconstruction method (DISP) and improvements to the standard background rejection technique, which by themselves are effective ways to increase the gamma-ray statistics and improve the sensitivity of the analysis, are implemented to overcome the above-mentioned issues. As a result, the angular resolution at the preselection level is improved by 5 - 10% for events at 0.5◦ offset angle and by 20 - 30% for events at 2◦ offset angle. The background rate at large offset angles is decreased nearly to a level typical for offset angles below 2.5◦. Thereby, sensitivity improvements of 10 - 20% are achieved for the proposed analysis compared to the standard analysis at small offset angles. Developed analysis also allows for the usage of events at large offset angles up to approximately 4◦, which was not possible before. This analysis method is applied to the analysis of the Galactic plane data above 10 TeV. As a result, 40 sources out of the 78 presented in the H.E.S.S. Galactic plane survey (HGPS) are detected above 10 TeV. Among them are representatives of all source classes that are present in the HGPS catalogue; namely, binary systems, supernova remnants, pulsar wind nebulae and composite objects. The potential of the improved analysis method is demonstrated by investigating the more than 10 TeV emission for two objects: the region associated with the shell-type SNR HESS J1731−347 and the PWN candidate associated with PSR J0855−4644 that is coincident with Vela Junior (HESS J0852−463).
Die vorliegende Arbeit thematisiert die Synthese und Charakterisierung von neuen funktionalisierten ionischen Flüssigkeiten und deren Polymerisation. Die ionischen Flüssigkeiten wurden dabei sowohl mit polymerisierbaren Kationen als auch Anionen hergestellt. Zum einen wurden bei thermisch initiierten Polymerisationen Azobis(isobutyronitril) (AIBN) verwendet und zum anderen dienten bei photochemisch initiierten Polymerisationen Bis-4-(methoxybenzoyl)diethylgermanium (Ivocerin®) als Radikalstarter.
Mittels Gelpermeationschromatographie konnte das Homopolymer Polydimethylaminoethylmethacrylat untersucht werden, welches erst im Anschluss an die GPC-Messungen polymeranalog modifiziert wurde. Dabei wurden nach einer Quaternisierung und anschließender Anionenmetathese bei diesen Polymeren die Grenzviskositäten bestimmt und mit den Grenzviskositäten der direkt polymerisierten ionischen Flüssigkeiten verglichen. Bei der direkten Polymerisation von Poly(N-[2-(Methacryloyloxy)ethyl]-N-butyl-N,N-dimethyl-ammoniumbis(trifluormethylsulfonyl)imid) lag [η_Huggins] bei 100 mL/g und bei dem polymeranalog hergestellten Polymer betrug [η_Huggins] = 40 mL/g.
Die ionischen Flüssigkeiten mit polymerisierbaren funktionellen Gruppen wurden mittels Photo-DSC hinsichtlich der maximalen Polymerisationsgeschwindigkeit (Rpmax), der Zeit, in der dieses Maximum erreicht wurde, tmax, ihrer Glasüberganstemperatur (Tg) und des Umsatzes an Vinylprotonen untersucht. Bei diesen Messungen wurde zum einen der Einfluss der unterschiedlichen Alkylkettenlänge am Ammoniumion und der Einfluss von verschiedenen Anionen bei gleichbleibender Kationenstruktur analysiert. So polymerisierte das ethylsubstituierte Kation mit einer tmax von 21 Sekunden am langsamsten. Die maximale Polymerisationsgeschwindigkeit (Rpmax) betrug 3.3∙10-2 s-1. Die tmax Werte der übrigen alkylsubstituierten ionischen Flüssigkeiten mit einer polymerisierbaren funktionellen Gruppe hingegen lagen zwischen 10 und 15 Sekunden. Die Glasübergangstemperaturen der mittels photoinduzierter Polymerisation hergestellten Polymere lagen mit 44 bis 55 °C nahe beieinander. Alle Monomere zeigten einen hohen Umsatz der Vinylprotonen; er betrug zwischen 93 und 100%.
Mithilfe einer Bandanlage, ausgerüstet mit einer LED (λ = 395 nm), konnten Polymerfilme hergestellt werden. Der Umsatz an Doppelbindungsäquivalenten dieser Filme wurde anhand der 1H-NMR Spektroskopie bestimmt. Bei der dynamisch-mechanischen Analyse wurden die Polymerfilme mit einer konstanten Heizrate und Frequenz periodisch wechselnden Beanspruchungen ausgesetzt, um die Glasübergangstemperaturen zu bestimmen. Die niedrigste Tg mit 26 °C besaß das butylsubstituierte N-[2-(Methacryloyloxy)ethyl]-N-butyl-N,N-dimethyl-ammoniumbis(trifluormethylsulfonyl)imid, welches als Polymerfilm mit Ivocerin® als Initiator hergestellt wurde, wohingegen die höchste Tg bei dem gleichen Polymer, welches direkt durch freie radikalische Polymerisation der ionischen Flüssigkeit in Masse mit AIBN hergestellt wurde, 51 °C betrug. Zusätzlich wurden die Filme unter dem Aspekt der Topographie mit einem Rasterkraftmikroskop untersucht, welches eine Domänenstruktur des Polymers N-[2-(methacryloyloxy)ethyl]-N-butyl-N,N-dimethyl-ammonium tris(pentafluorethyl)trifluorphosphat offenbarte.
This thesis focuses on the study of marked Gibbs point processes, in particular presenting some results on their existence and uniqueness, with ideas and techniques drawn from different areas of statistical mechanics: the entropy method from large deviations theory, cluster expansion and the Kirkwood--Salsburg equations, the Dobrushin contraction principle and disagreement percolation.
We first present an existence result for infinite-volume marked Gibbs point processes. More precisely, we use the so-called entropy method (and large-deviation tools) to construct marked Gibbs point processes in R^d under quite general assumptions. In particular, the random marks belong to a general normed space S and are not bounded. Moreover, we allow for interaction functionals that may be unbounded and whose range is finite but random. The entropy method relies on showing that a family of finite-volume Gibbs point processes belongs to sequentially compact entropy level sets, and is therefore tight.
We then present infinite-dimensional Langevin diffusions, that we put in interaction via a Gibbsian description. In this setting, we are able to adapt the general result above to show the existence of the associated infinite-volume measure. We also study its correlation functions via cluster expansion techniques, and obtain the uniqueness of the Gibbs process for all inverse temperatures β and activities z below a certain threshold. This method relies in first showing that the correlation functions of the process satisfy a so-called Ruelle bound, and then using it to solve a fixed point problem in an appropriate Banach space. The uniqueness domain we obtain consists then of the model parameters z and β for which such a problem has exactly one solution.
Finally, we explore further the question of uniqueness of infinite-volume Gibbs point processes on R^d, in the unmarked setting. We present, in the context of repulsive interactions with a hard-core component, a novel approach to uniqueness by applying the discrete Dobrushin criterion to the continuum framework. We first fix a discretisation parameter a>0 and then study the behaviour of the uniqueness domain as a goes to 0. With this technique we are able to obtain explicit thresholds for the parameters z and β, which we then compare to existing results coming from the different methods of cluster expansion and disagreement percolation.
Throughout this thesis, we illustrate our theoretical results with various examples both from classical statistical mechanics and stochastic geometry.
In der vorliegenden Arbeit wurde sich mit der Frage beschäftigt, ob und wenn ja inwiefern das spanische que, neben seinen klassischen Verwendungsweisen als Pronomen und Konjunktion, als Diskursmarker (DM) fungieren kann, also ob que in bestimmten Kontexten seinen propositionalen Gehalt verliert und rein diskursive Funktionen übernimmt.
Es wurden 128 Beispiele von satzinitialen que untersucht, welche sich zunächst nicht eindeutig als grammatisches Element klassifizieren lassen. Die Beispiele entstammen einem Korpus, welches auf einem auf Grundlage der zweiten Staffel der Netflix-Serie “Élite” erstellten Transkript basiert. Das Material wurde anhand von fünf auf Grundlage der Forschungsliteratur erstellten Kriterien analysiert und je nach Erfüllung oder Nicht-Erfüllung in die Kategorien “nicht pragmatikalisiert” (NP), “teilweise pragmatikalisiert” (TP) und “pragmatikalisiert” (P) eingeordnet. Innerhalb jeder dieser Kategorien wurde(n) die entsprechende(n) grammatische(n) bzw. pragmatische(n) Funktion(en) spezifiziert und die Ergebnisse in einem Raster zusammengetragen. Für die Funktionszuordnung in der Kategorie (P) wurde hierbei auf die DM-Klassifizierung von Martín Zorraquino und Portolés 1999 zurückgegriffen und hierbei teilweise noch einmal weiter spezifiziert.
Bei der Analyse haben sich 89 als P, 34 als TP und fünf Beispiele als NP herausgestellt. Von den 89 als P eingestuften que wurde der Großteil (84) als “comentador” beschrieben - als DM, der einen Kommentar einführt. So wurden insgesamt 72 que als DM eingestuft, die einen erklärenden Kommentar einleiten.
Es wurde hiermit eine objektive Einstufung von que als DM erreicht, welche gleichzeitig erste Aufschlüsse über die spezifischen Funktionen von que als DM gibt. Die Nutzung konkreter Kriterien zur Analyse von potentiellen DM gewährleistet Objektivität und leistet einen Beitrag zur Systematisierung der teils von Uneinigkeiten und Interpretationen geprägten DM-Forschung.
Die Dissertation legt ihren Schwerpunkt auf die synchronische und diachronische Variation im Gebrauch der französischen Kausalkonjunktion parce que sowie auf die Interaktion mit den außersprachlichen Variablen Alter und sozioprofessionelle Kategorie. Basierend auf vorausgehenden makrodiachronischen Studien, die Anhaltspunkte dafür liefern, dass die Konjunktion einen Prozess der Pragmatikalisierung durchlaufen hat und weiterhin durchläuft, wurde ein Untersuchungskorpus von 56 Interviews aus den diachronisch distinkten Korpora ESLO1, ESLO2 und LangAge extrahiert. Dieses Untersuchungskorpus diente als Grundlage für Panelstudien und Trendstudien, die darauf ausgerichtet waren, die Pragmatikalisierung von parce que aus einem mikrodiachronischen Gesichtspunkt zu verifizieren. Zusätzlich zu der diachronischen Perspektive wurde eine synchronische Perspektive eingenommen, um die Variation im Gebrauch der Konjunktion so einem diachronischen Phänomen wie dem age grading oder der apparent time zuordnen zu können. Ausgehend von der Theorie der Konstruktionsgrammatik wurden parce que enthaltende Konstruktionen bottom-up annotiert und in fünf Pragmatikalitätsgrade kategorisiert (pra0–pra4). Diese wurden anschließend quantifiziert und in Abhängigkeit des Geburtsjahres und der sozioprofessionellen Kategorie der (männlichen) Sprecher mithilfe mehrerer R-Modelle wie ctrees, trees, lm, hclust und kmeans analysiert.
Die Frequenzentwicklung der Pragmatikalitätsgrade bestätigte die Pragmatikalisierungshypothese in einem mikrodiachronischen Rahmen. Zudem konnte ein quantitativer Rückgang im Gebrauch der Konstruktionen am nicht- oder weniger pragmatikalisierten (pra0, pra1) Pol festgestellt werden, während Verwendungsweisen höherer Pragmatikalisierungsgrade (pra2–pra4) über 40 Jahre vergleichsweise stabil blieben.
Obwohl für pra2 kein signifikanter Wandel hervortrat, wies dessen Entwicklung bei den Sprechern im mittleren Lebensalter sowie das synchronische Muster in Abhängigkeit von Alter (oder Geburtsjahr) und von sozioprofessioneller Kategorie dennoch in Richtung einer zugrundeliegenden diachronischen Variation. Diese könnte als ein durch die sozialen Transformationen der 1960er und 1970er Jahre katalysiertes Phänomen des age grading interpretiert werden. Für die näher am pragmatischen Pol situierten Gebrauchsweisen (pra3 und pra4) konnte keine klare Tendenz ermittelt werden.
Die Ergebnisse fordern diachronische Konzepte wie age grading und apparent time heraus, indem sie die Simplizität der zugrundeliegenden Mechanismen sowie die gängigen Methoden, diese zu identifizieren, infrage stellen.
In den vergangenen Jahren hat sich die Politikdidaktik zunehmend mit dem Einsatz von Narrationen im Politikunterricht beschäftigt, denn neben Sachtexten bietet auch die Belletristik die Möglichkeit, sich mit politischen Themen auseinanderzusetzen. Insbesondere die Literatur von Ferdinand von Schirach hat in den letzten Jahren zunehmend Anklang in der Gesellschaft gefunden. Von Schirachs Texte greifen gesellschaftskritische Themen auf, beleuchten diese aus verschiedenen Perspektiven und fordern zur Meinungsbildung heraus. Aus diesem Grund weisen von Schirachs Narrationen ein hohes Potential für die Politische Bildung auf. Politische Bildung schließt auch die Rechterziehung ein. Der Fall Collini von Ferdinand von Schirach setzt sich sowohl mit rechtlichen, als auch mit politischen Themen im Sinne der Rechtserziehung auseinander. In der vorliegenden Masterarbeit wird der Frage nachgegangen, inwieweit der Roman Der Fall Collini von Ferdinand von Schirach als Narration eine Chance für politisch-rechtliches Lernen im Politikunterricht darstellt. Um die Forschungsfrage zu beantworten, werden die Lernchancen und -grenzen des Romans hinsichtlich seiner Thematik und seines Genres, sowie durch den Roman geförderten Kompetenzen herausgearbeitet und die durch ihn möglichen fächerübergreifenden Bezüge verdeutlicht. Durch die Auseinandersetzung mit von Schirachs Werk beschäftigen sich die Schülerinnen und Schüler mit politisch-rechtlichen Themen, wie dem Spannungsverhältnis von Recht und Gerechtigkeit, dem Ablauf von Strafgerichtsverfahren, dem theoretischen Anspruch des Rechtsstaates und dessen realen Schwächen. Zudem fördert die Auseinandersetzung mit dem Roman Der Fall Collini die vier fachbezogenen Kompetenzen der Politischen Bildung, sowie Multiperspektivität und exemplarisches Lernen. Des Weiteren verknüpft der Roman historische, politisch-rechtliche und moralisch-ethische Aspekte miteinander, wodurch fächerübergreifende Bezüge mit den Fächern Geschichte, Deutsch und L-E-R hergestellt werden können. Darüber hinaus spricht der Justizroman als Narration seine Leserinnen und Leser auch emotional an und fördert somit eine ganzheitliche und nachhaltige Wissensvermittlung im Sinne der Rechtserziehung. Es hat sich gezeigt, dass Der Fall Collini von Ferdinand von Schirach sich für die unterrichtliche Beschäftigung innerhalb der Politischen Bildung besonders eignet.
Die Dissertation geht der grundlegenden Forschungsfrage nach, wie die Liberal-Demokratische Partei Deutschlands (LDPD) auf lokaler Ebene die ihr zugeschriebene Rolle im politischen Alltag ausfüllte, in welchem Verhältnis sie zum System der DDR stand sowie welche Handlungsspielräume bestanden und genutzt wurden. Ihre Parteiarbeit vor Ort vom Mauerbau bis in die 1980er Jahre hinein blieb von der Forschung bisher weitgehend unbeobachtet, da das Interesse verstärkt der herrschenden SED oder den rebellischen Ansätzen der LDPD in den 1940er und späten 1980er Jahren galt. Die vorliegende Arbeit hat einen ersten Schritt unternommen, die liberale Partei auf Kreis- und Ortsebene zu untersuchen, und trägt dazu bei, diese Lücken zu schließen. Anhand der Fallbeispiele Gotha, Erfurt-Stadt und Eisenach beleuchtet die Dissertation die interne Parteiorganisation, Verhalten und Motivationen der Mitglieder sowie unter Berücksichtigung netzwerktheoretischer Ansätze die Verflechtungen der lokalen Parteifunktionsträger, die sich in die kommunale Arbeit vor Ort einmischten. Informations- und Situationsberichte sowie Korrespondenzen und Organisationsunterlagen gaben Auskunft über Selbstbilder, Aktivität, Themen und Kommunikationsaspekte. Deutlich werden die strengen Kontrollmechanismen innerhalb der Partei sowie das Spannungsfeld zwischen einer klaren Unterstützung der SED-Politik und individuell eigen-sinnigem Verhalten.
Durch die Analysekategorie des „Eigen-Sinns“ als Form der vielschichtigen Aneig- nung von Herrschaftsstrukturen in Abgrenzung zu den Begriffen Opposition und Widerstand wird gezeigt, dass die LDPD-Mitglieder in den untersuchten Kreisen sich zwar Freiheiten der Kritikäußerung nahmen sowie weitgehend selbstständig den Grad ihrer Aktivität bestimmten, dabei die grundlegenden Systemfragen jedoch nicht berührten. Es existierten viele unterschiedliche Lebenswelten der Akteure, abhängig von Tätigkeitsfeld, Motivation und Umfeld, die zu verschiedenen Taktiken und Ausprägungen des Eigen-Sinns bei einfachen Mitgliedern und den lokalen Funktionsträgern führten. Durch ihre kommunale Mitarbeit jedoch kümmerten sich die Liberaldemokraten in den Gemeinden um die drängendsten Versorgungsprobleme und sorgten mit der aktiven Rekrutierung ihrer Mitglieder für Arbeitsprogramme und Wettbewerbe für eine Beteiligung der LDPD an der Beseitigung der schlimmsten Mängel im öffentlichen Raum. Damit leisteten sie einen Beitrag zur Dämpfung der allgemeinen Unzufriedenheit und stärkten mittelbar das DDR-System. Im Gegenzug erhielten sie dafür von der SED eingeschränkte und klar definierte Handlungsspielräume. Mittels der beruflichen Verankerung der meisten aktiven Liberaldemokraten im ökonomischen Bereich konnte viel Praxiswissen herausgebildet werden, mit dem sich die untersuchten LDPD-Verbände im Rahmen der gewährten Gestaltungsfreiheit durchaus selbstbewusst in kommunale Prozesse einmischten. Für die Stabilisierung des Systems über die lange Zeit zwischen Mauerbau und Mauerfall spielten sie damit eine wichtige Rolle.
Die Vermischung von Distanzierung, Akzeptanz, Widerspruch und Gehorsam machen die Parteibasis und auch die aktiven Parteifunktionsträger auf der unteren Ebene zu einem sehr spannenden Untersuchungsfeld, das auch noch längst nicht ausgeschöpft ist.
Zusammenfassung zur Dissertation „Neuartige DBD-Fluoreszenzfarbstoffe: Synthese, Untersuchungen und Anwendungen“ von Leonard John
In dieser Arbeit konnten auf Basis der etablierten [1,3]-Dioxolo[4,5-f][1,3]benzodioxol (DBD) Fluoreszenzfarbstoffe zwei neue Konzepte zur Darstellung unsymmetrisch funktionalisierter DBD-Fluorophore entwickelt werden. Die Variation der elektronenziehenden Reste führte zu einer Erweiterung des Farbspektrums an DBD-Fluorophoren, wobei alle weiteren spektroskopischen Parameter (Fluoreszenzlebenszeit, -quantenausbeute und STOKES-Verschiebung) unverändert hohe Werte aufweisen. Neben der Variation der elektronenziehenden Reste wurde das "pi"-System des DBD-Farbstoffs mit der Einführung von Stilben-, und Tolan-Derivaten vergrößert. Stilben-Derivate zeigten ähnlich gute spektroskopische Eigenschaften wie die bereits etablierten DBD-Farbstoffe.
Fluorophore mit langwelliger Emission sind auf Grund der großen Gewebe-Eindringtiefe besonders interessant für biologische Anwendungen. Da der langwelligste Vertreter der O4-DBD-Farbstoffe in polaren Medien nur schwer löslich ist, wurde ein Weg zur Einführung löslichkeitsvermittelnder Gruppen gesucht. Hierbei fiel die Wahl auf eine Carbonsäure-Gruppe zur Steigerung der Hydrophilie. Eine von vier untersuchten Methoden erwies sich als zielführend, sodass das gewünschte Molekül isoliert werden konnte. Eine erhöhte Wasserlöslichkeit wurde allerdings nicht beobachtet.
Zur Erforschung von Fettstoffwechselkrankheiten wie der ALZHEIMER-Krankheit werden fluoreszenzmarkierte Lipide benötigt. Um unterschiedliche Bereiche einer Membran zu untersuchen, war das Ziel, den Fluorophor an unterschiedlichen Stellen innerhalb der Fettsäure zu lokalisieren. Hierbei sollte die Gesamtkettenlänge des DBD-Lipids einer C18-Kette, analog der Stearinsäure, entsprechen. Durch die stufenweise Einführung der Reste gelang es, drei DBD-Lipide herzustellen, wobei sich der Fluorophor an unterschiedlichen Positionen innerhalb der Kette befindet. Die photophysikalischen Eigenschaften der Lipide weichen nur marginal von denen der reinen Fluorophore ab. Eine Einlagerung in giant unilamellar vesicles (GUVs) konnte für zwei Derivate beobachtet werden, wobei keine domänenspezifisch war.
Ein weiteres Ziel dieser Arbeit war es, die vier Sauerstoffatome im DBD-Grundkörper stufenweise durch Schwefelatome zu ersetzen und die Ringgrößen des DBD-Fluorophors zu variieren. Für die Ringgröße zeigte der 1,2-S2-DBD mit jeweils zwei Fünfringen die besten spektroskopischen Eigenschaften. Durch die Synthese von zwei weiteren schwefelhaltigen DBD-Grundkörpern (S1- und 1,4-S2-DBD) konnten insgesamt drei neue Farbstoffklassen zugänglich gemacht werden. Für alle neuen Chromophore wurden elektronenziehende Reste (Aldehyd, Acyl, Ester, Carboxy) eingeführt und die jeweiligen Derivate spektroskopisch untersucht. Mit steigender Anzahl an Schwefel-Atomen im Grundkörper zeigt sich eine bathochrome Verschiebung der Emission,
wobei die Werte für die Fluoreszenzlebenszeit- und -quantenausbeute abnehmen. Die optimalen spektroskopischen Eigenschaften aus langwelliger Emission, hoher Fluoreszenzlebenszeit und -quantenausbeute zeigt das 1,4-S2-Dialdehyd-Derivat. Für die S1- und 1,2-S2-Dialdehyd-
Derivate wurden Konzepte entwickelt, um bioreaktive Reste (Alkin, HOSu, Maleimid) einzuführen und die Fluorophore in biologischen Systemen anwenden zu können.
Filaments are omnipresent features in the solar chromosphere, one of the atmospheric layers of the Sun, which is located above the photosphere, the visible surface of the Sun. They are clouds of plasma reaching from the photosphere to the chromosphere, and even to the outer-most atmospheric layer, the corona. They are stabalized by the magnetic field. If the magnetic field is disturbed, filaments can erupt as coronal mass ejections (CME), releasing plasma into space, which can also hit the Earth. A special type of filaments are polar crown filaments, which form at the interface of the unipolar field of the poles and flux of opposite magnetic polarity, which was transported towards the poles. This flux transport is related to the global dynamo of the Sun and can therefore be analyzed indirectly with polar crown filaments. The main objective of this thesis is to better understand the physical properties and environment of high-latitude and polar crown filaments, which can be approached from two perspectives: (1) analyzing the large-scale properties of high-latitude and polar crown filaments with full-disk Hα observations from the Chromospheric Telescope (ChroTel) and (2) determining the relation of polar crown and high-latitude filaments from the chromosphere to the lower-lying photosphere with high-spatial resolution observations of the Vacuum Tower Telescope (VTT), which reveal the smallest details.
The Chromospheric Telescope (ChroTel) is a small 10-cm robotic telescope at Observatorio del Teide on Tenerife (Spain), which observes the entire Sun in Hα, Ca IIK, and He I 10830 Å. We present a new calibration method that includes limb-darkening correction, removal of non-uniform filter transmission, and determination of He I Doppler velocities. Chromospheric full-disk filtergrams are often obtained with Lyot filters, which may display non-uniform transmission causing large-scale intensity variations across the solar disk. Removal of a 2D symmetric limb-darkening function from full-disk images results in a flat background. However, transmission artifacts remain and are even more distinct in these contrast-enhanced images. Zernike polynomials are uniquely appropriate to fit these large-scale intensity variations of the background. The Zernike coefficients show a distinct temporal evolution for ChroTel data, which is likely related to the telescope’s alt-azimuth mount that introduces image rotation. In addition, applying this calibration to sets of seven filtergrams that cover the He I triplet facilitates determining chromospheric Doppler velocities. To validate the method, we use three datasets with varying levels of solar activity. The Doppler velocities are benchmarked with respect to co-temporal high-resolution spectroscopic data of the GREGOR Infrared Spectrograph (GRIS). Furthermore, this technique can be applied to ChroTel Hα and Ca IIK data. The calibration method for ChroTel filtergrams can be easily adapted to other full-disk data exhibiting unwanted large-scale variations. The spectral region of the He I triplet is a primary choice for high-resolution near-infrared spectropolarimetry. Here, the improved calibration of ChroTel data will provide valuable context data.
Polar crown filaments form above the polarity inversion line between the old magnetic flux of the previous cycle and the new magnetic flux of the current cycle. Studying their appearance and their properties can lead to a better understanding of the solar cycle. We use full-disk data of the ChroTel at Observatorio del Teide, Tenerife, Spain, which were taken in three different chromospheric absorption lines (Hα 6563 Å, Ca IIK 3933 Å, and He I 10830 Å), and we create synoptic maps. In addition, the spectroscopic He I data allow us to compute Doppler velocities and to create synoptic Doppler maps. ChroTel data cover the rising and decaying phase of Solar Cycle 24 on about 1000 days between 2012 and 2018. Based on these data, we automatically extract polar crown filaments with image-processing tools and study their properties. We compare contrast maps of polar crown filaments with those of quiet-Sun filaments. Furthermore, we present a super-synoptic map summarizing the entire ChroTel database. In summary, we provide statistical properties, i.e. number and location of filaments, area, and tilt angle for both the maximum and declining phase of Solar Cycle 24. This demonstrates that ChroTel provides a
promising dataset to study the solar cycle.
The cyclic behavior of polar crown filaments can be monitored by regular full-disk Hα observations. ChroTel provides such regular observations of the Sun in three chromospheric wavelengths. To analyze the cyclic behavior and the statistical properties of polar crown filaments, we have to extract the filaments from the images. Manual extraction is tedious, and extraction with morphological image processing tools produces a large number of false positive detections and the manual extraction of these takes too much time. Automatic object detection and extraction in a reliable manner allows us to process more data in a shorter time. We will present an overview of the ChroTel database and a proof of concept of a machine learning application, which allows us a unified extraction of, for example, filaments from ChroTel data.
The chromospheric Hα spectral line dominates the spectrum of the Sun and other stars. In the stellar regime, this spectral line is already used as a powerful tracer of magnetic activity. For the Sun, other tracers are typically used to monitor solar activity. Nonetheless, the Sun is observed constantly in Hα with globally distributed ground-based full-disk imagers. The aim of this study is to introduce Hα as a tracer of solar activity and compare it to other established indicators. We discuss the newly created imaging Hα excess in the perspective of possible application for modelling of stellar atmospheres. In particular, we try to determine how constant is the mean intensity of the Hα excess and number density of low-activity regions between solar maximum and minimum. Furthermore, we investigate whether the active region coverage fraction or the changing emission strength in the active regions dominates time variability in solar Hα observations. We use ChroTel observations of full-disk Hα filtergrams and morphological image processing techniques to extract the positive and negative imaging Hα excess, for bright features (plage regions) and dark absorption features (filaments and sunspots), respectively. We describe the evolution of the Hα excess during Solar Cycle 24 and compare it to other well established tracers: the relative sunspot number, the F10.7 cm radio flux, and the Mg II index. Moreover, we discuss possible applications of the Hα excess for stellar activity diagnostics and the contamination of exoplanet transmission spectra. The positive and negative Hα excess follow the behavior of the solar activity over the course of the cycle. Thereby, positive Hα excess is closely correlated to the chromospheric Mg II index. On the other hand, the negative Hα excess, created from dark features like filaments and sunspots, is introduced as a tracer of solar activity for the first time. We investigated the mean intensity distribution for active regions for solar minimum and maximum and found that the shape of both distributions is very similar but with different amplitudes. This might be related with the relatively stable coronal temperature component during the solar cycle. Furthermore, we found that the coverage fraction of Hα excess and the Hα excess of bright features are strongly correlated, which will influence modelling of stellar and exoplanet atmospheres.
High-resolution observations of polar crown and high-latitude filaments are scarce. We present a unique sample of such filaments observed in high-resolution Hα narrow-band filtergrams and broad-band images, which were obtained with a new fast camera system at the VTT. ChroTel provided full-disk context observations in Hα, Ca IIK, and He I 10830 Å. The Helioseismic and Magnetic Imager (HMI) and the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamics Observatory (SDO) provided line-of-sight magnetograms and ultraviolet (UV) 1700 Å filtergrams, respectively. We study filigree in the vicinity of polar crown and high-latitude filaments and relate their locations to magnetic concentrations at the filaments’ footpoints. Bright points are a well studied phenomenon in the photosphere at low latitudes, but they were not yet studied in the quiet network close to the poles. We examine size, area, and eccentricity of bright points and find that their morphology is very similar to their counterparts at lower latitudes, but their sizes and areas are larger. Bright points at the footpoints of polar crown filaments are preferentially located at stronger magnetic flux concentrations, which are related to bright regions at the border of supergranules as observed in UV filtergrams. Examining the evolution of bright points on three consecutive days reveals that their amount increases while the filament decays, which indicates they impact the equilibrium of the cool plasma contained in filaments.
“Embodied Practices – Looking From Small Places” is an edited transcript of a conversation between theatre and performance scholar Sruti Bala (University of Amsterdam) and sociologist, criminologist and anthropologist Dylan Kerrigan (University of Leicester) that took place as an online event in November 2020. Throughout their talk, Bala and Kerrigan engage with the legacy of Haitian anthropologist Michel-Rolph Trouillot. Specifically, they focus on his approach of looking from small units, such as small villages in Dominica, outwards to larger political structures such as global capitalism, social inequalities and the distribution of power. They also share insights from their own research on embodied practices in the Caribbean, Europe and India and answer questions such as: What can research on and through embodied practices tell us about systems of power and domination that move between the local and the global? How can performance practices which are informed by multiple locations and cultures be read and appreciated adequately? Sharing insights from his research into Guyanese prisons, Kerrigan outlines how he aims to connect everyday experiences and struggles of Caribbean people to trans-historical and transnational processes such as racial capitalism and post/coloniality. Furthermore, he elaborates on how he uses performance practices such as spoken word poetry and data verbalisation to connect with systematically excluded groups. Bala challenges naïve notions about the inherent transformative potential of performance in her research on performance and translation. She points to the way in which performance and its reception is always already inscribed in what she calls global or planetary asymmetries. At the conclusion of this conversation, they broach the question: are small places truly as small as they seem?
Active Galactic Nuclei (AGN) are considered to be the main powering source of active galaxies, where central Super Massive Black Holes (SMBHs), with masses between 106 and 109 M⊙ gravitationally pull the surrounding material via accre- tion. AGN phenomenon expands over a very wide range of luminosities, from the most luminous high-redshift quasars (QSOs), to the local Low-Luminosity AGN (LLAGN), with significantly weaker luminosities. While "typical" luminous AGNs distinguish themselves by their characteristical blue featureless continuum, the Broad Emission Lines (BELs) with Full Widths at Half Maximum (FWHM) in order of few thousands km s1, arising from the so-called Broad Line Region (BLR), and strong radio and/or X-ray emission, detection of LLAGNs on the other hand is quite chal- lenging due to their extremely weak emission lines, and absence of the power-law continuum. In order to fully understand AGN evolution and their duty-cycles across cosmic history, we need a proper knowledge of AGN phenomenon at all luminosi- ties and redshifts, as well as perspectives from different wavelength bands.
In this thesis I present a search for AGN signatures in central spectra of 542 local (0.005 < z < 0.03) galaxies from the Calar Alto Legacy Integral Field Area (CALIFA) survey. The adopted aperture of 3′′ × 3′′ corresponds to central ∼ 100 − 500 pc for the redshift range of CALIFA. Using the standard emission-line ratio diagnostic diagrams, we initially classified all CALIFA emission-line galaxies (526) into star- forming, LINER-like, Seyfert 2 and intermediates. We further detected signatures of the broad Hα component in 89 spectra from the sample, of which more than 60% are present in the central spectra of LINER-like galaxies. These BELs are very weak, with luminosities in range 1038 − 1041 erg s−1, but with FWHMs between 1000 km s−1 and 6000 km s−1, comparable to those of luminous high-z AGN. This result implies that type 1 AGN are in fact quite frequent in the local Universe. We also identified additional 29 Seyfert 2 galaxies using the emission-line ratio diagnostic diagrams.
Using the MBH − σ∗ correlation, we estimated black hole masses of 55 type 1 AGN from CALIFA, a sample for which we had estimates of bulge stellar velocity dispersions σ∗. We compared these masses to the ones that we estimated from the virial method and found large discrepancies. We analyzed the validity of both meth- ods for black hole mass estimation of local LLAGN, and concluded that most likely virial scaling relations can no longer be applied as a valid MBH estimator in such low-luminosity regime. These black holes accrete at very low rate, having Edding- ton ratios in range 4.1 × 10−5 − 2.4 × 10−3. Detection of BELs with such low lumi- nosities and at such low Eddington rates implies that these LLAGN are still able to form the BLR, although with probably modified structure of the central engine.
In order to obtain full picture of black hole growth across cosmic time, it is es- sential that we study them in different stages of their activity. For that purpose, we estimated the broad AGN Luminosity Function (AGNLF) of our entire type 1 AGN sample using the 1/Vmax method. The shape of AGNLF indicates an apparent flattening below luminosities LHα ∼ 1039 erg s−1. Correspondingly we estimated ac- tive Black Hole Mass Function (BHMF) and Eddington Ration Distribution Function (ERDF) for a sub-sample of type 1 AGN for which we have MBH and λ estimates. The flattening is also present in both BHMF and ERDF, around log(MBH) ∼ 7.7 and log(λ) < 3, respectively. We estimated the fraction of active SMBHs in CALIFA by comparing our active BHMF to the one of the local quiescent SMBHs. The shape of
the active fraction which decreases with increasing MBH, as well as the flattening of AGNLF, BHMF and ERDF is consistent with scenario of AGN cosmic downsizing.
To complete AGN census in the CALIFA galaxy sample, it is necessary to search for them in various wavelength bands. For the purpose of completing the census we performed cross-correlations between all 542 CALIFA galaxies and multiwavelength surveys, Swift – BAT 105 month catalogue (in hard 15 - 195 keV X-ray band), and NRAO VLA Sky Survey (NVSS, in 1.4 GHz radio domain). This added 1 new AGN candidate in X-ray, and 7 in radio wavelength band to our local LLAGN count.
It is possible to detect AGN emission signatures within 10 – 20 kpc outside of the central galactic regions. This may happen when the central AGN has recently switched off and the photoionized material is spread across the galaxy within the light-travel-time, or the photoionized material is blown away from the nucleus by outflows. In order to detect these extended AGN regions we constructed spatially resolved emission-line ratio diagnostic diagrams of all emission-line galaxies from the CALIFA, and found 1 new object that was previously not identified as AGN.
Obtaining the complete AGN census in CALIFA, with five different AGN types, showed that LLAGN contribute a significant fraction of 24% of the emission-line galaxies in the CALIFA sample. This result implies that AGN are quite common in the local Universe, and although being in very low activity stage, they contribute to large fraction of all local SMBHs. Within this thesis we approached the upper limit of AGN fraction in the local Universe and gained some deeper understanding of the LLAGN phenomenon.
Transient permeability in porous and fractured sandstones mediated by fluid-rock interactions
(2021)
Understanding the fluid transport properties of subsurface rocks is essential for a large number of geotechnical applications, such as hydrocarbon (oil/gas) exploitation, geological storage (CO2/fluids), and geothermal reservoir utilization. To date, the hydromechanically-dependent fluid flow patterns in porous media and single macroscopic rock fractures have received numerous investigations and are relatively well understood. In contrast, fluid-rock interactions, which may permanently affect rock permeability by reshaping the structure and changing connectivity of pore throats or fracture apertures, need to be further elaborated. This is of significant importance for improving the knowledge of the long-term evolution of rock transport properties and evaluating a reservoir’ sustainability. The thesis focuses on geothermal energy utilization, e.g., seasonal heat storage in aquifers and enhanced geothermal systems, where single fluid flow in porous rocks and rock fracture networks under various pressure and temperature conditions dominates.
In this experimental study, outcrop samples (i.e., Flechtinger sandstone, an illite-bearing Lower Permian rock, and Fontainebleau sandstone, consisting of pure quartz) were used for flow-through experiments under simulated hydrothermal conditions. The themes of the thesis are (1) the investigation of clay particle migration in intact Flechtinger sandstone and the coincident permeability damage upon cyclic temperature and fluid salinity variations; (2) the determination of hydro-mechanical properties of self-propping fractures in Flechtinger and Fontainebleau sandstones with different fracture features and contrasting mechanical properties; and (3) the investigation of the time-dependent fracture aperture evolution of Fontainebleau sandstone induced by fluid-rock interactions (i.e., predominantly pressure solution). Overall, the thesis aims to unravel the mechanisms of the instantaneous reduction (i.e., direct responses to thermo-hydro-mechanical-chemical (THMC) conditions) and progressively-cumulative changes (i.e., time-dependence) of rock transport properties.
Permeability of intact Flechtinger sandstone samples was measured under each constant condition, where temperature (room temperature up to 145 °C) and fluid salinity (NaCl: 0 ~ 2 mol/l) were stepwise changed. Mercury intrusion porosimetry (MIP), electron microprobe analysis (EMPA), and scanning electron microscopy (SEM) were performed to investigate the changes of local porosity, microstructures, and clay element contents before and after the experiments. The results indicate that the permeability of illite-bearing Flechtinger sandstones will be impaired by heating and exposure to low salinity pore fluids. The chemically induced permeability variations prove to be path-dependent concerning the applied succession of fluid salinity changes. The permeability decay induced by a temperature increase and a fluid salinity reduction operates by relatively independent mechanisms, i.e., thermo-mechanical and thermo-chemical effects.
Further, the hydro-mechanical investigations of single macroscopic fractures (aligned, mismatched tensile fractures, and smooth saw-cut fractures) illustrate that a relative fracture wall offset could significantly increase fracture aperture and permeability, but the degree of increase depends on fracture surface roughness. X-ray computed tomography (CT) demonstrates that the contact area ratio after the pressure cycles is inversely correlated to the fracture offset. Moreover, rock mechanical properties, determining the strength of contact asperities, are crucial so that relatively harder rock (i.e., Fontainebleau sandstone) would have a higher self-propping potential for sustainable permeability during pressurization. This implies that self-propping rough fractures with a sufficient displacement are efficient pathways for fluid flow if the rock matrix is mechanically strong.
Finally, two long-term flow-through experiments with Fontainebleau sandstone samples containing single fractures were conducted with an intermittent flow (~140 days) and continuous flow (~120 days), respectively. Permeability and fluid element concentrations were measured throughout the experiments. Permeability reduction occurred at the beginning stage when the stress was applied, while it converged at later stages, even under stressed conditions. Fluid chemistry and microstructure observations demonstrate that pressure solution governs the long-term fracture aperture deformation, with remarkable effects of the pore fluid (Si) concentration and the structure of contact grain boundaries. The retardation and the cessation of rock fracture deformation are mainly induced by the contact stress decrease due to contact area enlargement and a dissolved mass accumulation within the contact boundaries. This work implies that fracture closure under constant (pressure/stress and temperature) conditions is likely a spontaneous process, especially at the beginning stage after pressurization when the contact area is relatively small. In contrast, a contact area growth yields changes of fracture closure behavior due to the evolution of contact boundaries and concurrent changes in their diffusive properties. Fracture aperture and thus permeability will likely be sustainable in the long term if no other processes (e.g., mineral precipitations in the open void space) occur.
Due to global climate change providing food security for an increasing world population is a big challenge. Especially abiotic stressors have a strong negative effect on crop yield. To develop climate-adapted crops a comprehensive understanding of molecular alterations in the response of varying levels of environmental stresses is required. High throughput or ‘omics’ technologies can help to identify key-regulators and pathways of abiotic stress responses. In addition to obtain omics data also tools and statistical analyses need to be designed and evaluated to get reliable biological results.
To address these issues, I have conducted three different studies covering two omics technologies. In the first study, I used transcriptomic data from the two polymorphic Arabidopsis thaliana accessions, namely Col-0 and N14, to evaluate seven computational tools for their ability to map and quantify Illumina single-end reads. Between 92% and 99% of the reads were mapped against the reference sequence. The raw count distributions obtained from the different tools were highly correlated. Performing a differential gene expression analysis between plants exposed to 20 °C or 4°C (cold acclimation), a large pairwise overlap between the mappers was obtained. In the second study, I obtained transcript data from ten different Oryza sativa (rice) cultivars by PacBio Isoform sequencing that can capture full-length transcripts. De novo reference transcriptomes were reconstructed resulting in 38,900 to 54,500 high-quality isoforms per cultivar. Isoforms were collapsed to reduce sequence redundancy and evaluated, e.g. for protein completeness level (BUSCO), transcript length, and number of unique transcripts per gene loci. For the heat and drought tolerant aus cultivar N22, I identified around 650 unique and novel transcripts of which 56 were significantly differentially expressed in developing seeds during combined drought and heat stress. In the last study, I measured and analyzed the changes in metabolite profiles of eight rice cultivars exposed to high night temperature (HNT) stress and grown during the dry and wet season on the field in the Philippines. Season-specific changes in metabolite levels, as well as for agronomic parameters, were identified and metabolic pathways causing a yield decline at HNT conditions suggested.
In conclusion, the comparison of mapper performances can help plant scientists to decide on the right tool for their data. The de novo reconstruction of rice cultivars without a genome sequence provides a targeted, cost-efficient approach to identify novel genes responding to stress conditions for any organism. With the metabolomics approach for HNT stress in rice, I identified stress and season-specific metabolites which might be used as molecular markers for crop improvement in the future.
Bottom-up synthetic biology is used for the understanding of how a cell works. It is achieved through developing techniques to produce lipid-based vesicular structures as cellular mimics. The most common techniques used to produce cellular mimics or synthetic cells is through electroformation and swelling method. However, the abovementioned techniques cannot efficiently encapsulate macromolecules such as proteins, enzymes, DNA and even liposomes as synthetic organelles. This urges the need to develop new techniques that can circumvent this issue and make the artificial cell a reality where it is possible to imitate a eukaryotic cell through encapsulating macromolecules. In this thesis, the aim to construct a cell system using giant unilamellar vesicles (GUVs) to reconstitute the mitochondrial molybdenum cofactor biosynthetic pathway. This pathway is highly conserved among all life forms, and therefore is known for its biological significance in disorders induced through its malfunctioning. Furthermore, the pathway itself is a multi-step enzymatic reaction that takes place in different compartments. Initially, GTP in the mitochondrial matrix is converted to cPMP in the presence of cPMP synthase. Further, produced cPMP is transported across the membrane to the cytosol, to be converted by MPT synthase into MPT. This pathway provides a possibility to address the general challenges faced in the development of a synthetic cell, to encapsulate large biomolecules with good efficiency and greater control and to evaluate the enzymatic reactions involved in the process.
For this purpose, the emulsion-based technique was developed and optimised to allow rapid production of GUVs (~18 min) with high encapsulation efficiency (80%). This was made possible by optimizing various parameters such as density, type of oil, the impact of centrifugation speed/time, lipid concentration, pH, temperature, and emulsion droplet volume. Furthermore, the method was optimised in microtiter plates for direct experimentation and visualization after the GUV formation. Using this technique, the two steps - formation of cPMP from GTP and the formation of MPT from cPMP were encapsulated in different sets of GUVs to mimic the two compartments. Two independent fluorescence-based detection systems were established to confirm the successful encapsulation and conversion of the reactants. Alternatively, the enzymes produced using bacterial expression and measured. Following the successful encapsulation and evaluation of enzymatic reactions, cPMP transport across mitochondrial membrane has been mimicked using GUVs using a complex mitochondrial lipid composition. It was found that the cPMP interaction with the lipid bilayer results in transient pore-formation and leakage of internal contents.
Overall, it can be concluded that in this thesis a novel technique has been optimised for fast production of functional synthetic cells. The individual enzymatic steps of the Moco biosynthetic pathway have successfully implemented and quantified within these cellular mimics.
The particle noch (‘still’) can have an additive reading similar to auch (‘also’). We argue that both particles indicate that a previously partially answered QUD is re-opened to add a further answer. The particles differ in that the QUD, in the case of auch, can be re-opened with respect to the same topic situation, whereas noch indicates that the QUD is re-opened with respect to a new topic situation. This account predicts a difference in the accommodation behavior of the two particles. We present an experiment whose results are in line with this prediction.
The ubiquitin-proteasome-system (UPS) is a cellular cascade involving three enzymatic steps for protein ubiquitination to target them to the 26S proteasome for proteolytic degradation. Several components of the UPS have been shown to be central for regulation of defense responses during infections with phytopathogenic bacteria. Upon recognition of the pathogen, local defense is induced which also primes the plant to acquire systemic resistance (SAR) for enhanced immune responses upon challenging infections. Here, ubiquitinated proteins were shown to accumulate locally and systemically during infections with Psm and after treatment with the SAR-inducing metabolites salicylic acid (SA) and pipecolic acid (Pip). The role of the 26S proteasome in local defense has been described in several studies, but the potential role during SAR remains elusive and was therefore investigated in this project by characterizing the Arabidopsis proteasome mutants rpt2a-2 and rpn12a-1 during priming and infections with Pseudomonas. Bacterial replication assays reveal decreased basal and systemic immunity in both mutants which was verified on molecular level showing impaired activation of defense- and SAR-genes. rpt2a-2 and rpn12a-1 accumulate wild type like levels of camalexin but less SA. Endogenous SA treatment restores local PR gene expression but does not rescue the SAR-phenotype. An RNAseq experiment of Col-0 and rpt2a-2 reveal weak or absent induction of defense genes in the proteasome mutant during priming. Thus, a functional 26S proteasome was found to be required for induction of SAR while compensatory mechanisms can still be initiated.
E3-ubiquitin ligases conduct the last step of substrate ubiquitination and thereby convey specificity to proteasomal protein turnover. Using RNAseq, 11 E3-ligases were found to be differentially expressed during priming in Col-0 of which plant U-box 54 (PUB54) and ariadne 12 (ARI12) were further investigated to gain deeper understanding of their potential role during priming.
PUB54 was shown to be expressed during priming and /or triggering with virulent Pseudomonas. pub54 I and pub54-II mutants display local and systemic defense comparable to Col-0. The heavy-metal associated protein 35 (HMP35) was identified as potential substrate of PUB54 in yeast which was verified in vitro and in vivo. PUB54 was shown to be an active E3-ligase exhibiting auto-ubiquitination activity and performing ubiquitination of HMP35. Proteasomal turnover of HMP35 was observed indicating that PUB54 targets HMP35 for ubiquitination and subsequent proteasomal degradation. Furthermore, hmp35-I benefits from increased resistance in bacterial replication assays. Thus, HMP35 is potentially a negative regulator of defense which is targeted and ubiquitinated by PUB54 to regulate downstream defense signaling. ARI12 is transcriptionally activated during priming or triggering and hyperinduced during priming and triggering. Gene expression is not inducible by the defense related hormone salicylic acid (SA) and is dampened in npr1 and fmo1 mutants consequently depending on functional SA- and Pip-pathways, respectively. ARI12 accumulates systemically after priming with SA, Pip or Pseudomonas. ari12 mutants are not altered in resistance but stable overexpression leads to increased resistance in local and systemic tissue. During priming and triggering, unbalanced ARI12 levels (i.e. knock out or overexpression) leads to enhanced FMO1 activation indicating a role of ARI12 in Pip-mediated SAR. ARI12 was shown to be an active E3-ligase with auto-ubiquitination activity likely required for activation with an identified ubiquitination site at K474. Mass spectrometrically identified potential substrates were not verified by additional experiments yet but suggest involvement of ARI12 in regulation of ROS in turn regulating Pip-dependent SAR pathways.
Thus, data from this project provide strong indications about the involvement of the 26S proteasome in SAR and identified a central role of the two so far barely described E3-ubiquitin ligases PUB54 and ARI12 as novel components of plant defense.