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Anglistentag 2012 Potsdam
(2013)
Katrin Röder and Ilse Wischer (Potsdam) Preface Section I: Recent Ireland: Visions and Revisions of Irishness from the 1990s to Today Sarah Heinz (Mannheim), Anton Kirchhofer (Oldenburg), Katharina Rennhak (Wuppertal) and Michaela Schrage-Früh (Mainz/Limerick) Recent Ireland: Visions and Revisions of Irishness from the 1990s to Today: Introduction Christopher Morash (Maynooth) Spectral Ireland: After the Celtic Tiger Jochen Achilles (Würzburg) Transnational Ireland and Elizabeth Kuti's Drama Silke Stroh (Münster) Revisioning Irish Postcolonialism: The Scottish Connection Joanna Rostek (Passau) Migration, Capital, Space: Econotopic Constellations in Recent Literature about Polish Migrants in Ireland Joachim Fischer (Limerick) Images of Germany in Irish Writing of the Last Ten Years (2002-2012) Werner Huber (Wien) The Brothers McDonagh, Filmmakers Christian Lassen (Oldenburg) The Passion of Saint Kitten, or: Desperately Seeking Mitzi, the Phantom Lady. Camp Responses to Interpellation and Subjection in Neil Jordan's Breakfast on Pluto Section II: Recent Trends in Romantic Studies Stefanie Fricke (LMU München), Rosa Karl (Erlangen-Nürnberg) and Gerold Sedlmayr (Dortmund) Recent Trends in Romantic Studies: Introduction Christoph Reinfandt (Tübingen) The Textures of Romanticism: Exploring Charlotte Smith's "Beachy Head" (1807) Ralf Haekel (Göttingen) Romantic Textualities Anthony John Harding (Saskatchewan) British Romanticism and the Transvaluation of Reading Christa Knellwolf King (Vienna) Imperial Myth-making in the Wake of Captain Cook's Death Monika Class (King's College London) Medical Case Narratives across Disciplinary and National Boundaries around 1800 Ute Berns (Hamburg) Romantic Poetry, Scientific Discourse and the Aesthetics of Nature Section III: Apocalypse and Literature Sibylle Baumbach (Mainz) and Anja Müller-Wood (Mainz) Apocalypse and Literature: Introduction Susanne Schmid (Berlin) Philip Pullman's His Dark Materials and Resistance to the Apocalypse Björn Quiring (Berlin) Judging the New Bloomusalem: Persistent Apocalyptic Remnants in Joyce's Ulysses Heike Hartung (Potsdam) Apocalypse and Old Age: Imminent Ends and Lacking Futures Apocalypse and Literature: Summaries Section IV: Comics and Graphic Novels Dirk Vanderbeke (Jena), Sebastian Domsch (Greifswald) and Astrid Böger (Hamburg) Comics and Graphic Novels: Introduction Martin Rowson (London) Towards a Theory of Literary Adaptation in Comic Book Format: A Graphic Response Nicola Glaubitz (Darmstadt) Vernacular Modernism: Martin Rowson's The Waste Land Ellen Grünkemeier (Hannover) Locating The League of Extraordinary Gentlemen in Victorian Literature and (Popular) Culture Sandra Heinen (Wuppertal) 'Indigenizing the Comic Book Medium': Techniques of Storytelling in Indian Graphic Novels Felicitas Meifert-Menhard (München) Evading the Sequence: Choose Your Own Comic Therese-Marie Meyer (Halle-Wittenberg) "My Country, My England": Warren Ellis's Graphic Novels and England at War Sandra Martina Schwab (Mainz) Richard Doyle's Sequential Art in Punch Section V: Electronic Discourse Markus Bieswanger (Bayreuth) and Andrea Sand (Trier) Electronic Discourse: Introduction Klaus P. Schneider (Bonn) Emerging E-mail Etiquette: Lay Perceptions of Appropriateness in Electronic Discourse Christian R. Hoffmann (Augsburg) E(-lectronic) Schmoozing? A Cross-Generic Study of Compliments in Blog Comments Jenny Arendholz (Augsburg) "How to stop strange people speaking to me" – A Syntactic and Interpersonal Perspective on Offering A dvice Online Tanja Angelovska and Angela Hahn (München) Features of Spoken L3 English in an Online Discourse Dagmar Deuber (Münster) and Andrea Sand (Trier) Computer-Mediated Communication in Singapore: Spoken Language Features in Weblogs and a Discussion Forum Christian Mair (Freiburg) Corpus Approaches to the Vernacular Web: Post-Colonial Diasporic Forums in West Africa and the Caribbean
The geological history of the Ponto-Caspian region, with alternating cycles of isolation and reconnection among the three main basins (Black and Azov Seas, and the more distant Caspian Sea) as well as between them and the Mediterranean Sea, profoundly affected the diversification of its aquatic fauna, leading to a high degree of endemism. Two alternative hypotheses on the origin of this amazing biodiversity have been proposed, corresponding to phases of allopatric separation of aquatic fauna among sea basins: a Late Miocene origin (10-6 MYA) vs. a more recent Pleistocene ancestry (<2 MYA). Both hypotheses support a vicariant origin of (1) Black + Azov Sea lineages on the one hand, and (2) Caspian Sea lineages on the other. Here, we present a study on the Ponto-Caspian endemic amphipod Pontogammarus maeoticus. We assessed patterns of divergence based on (a) two mitochondrial and one nuclear gene, and (b) a morphometric analysis of 23 morphological traits in 16 populations from South and West Caspian Sea, South Azov Sea and North-West Black Sea. Genetic data indicate a long and independent evolutionary history, dating back from the late Miocene to early Pleistocene (6.6-1.6 MYA), for an unexpected, major split between (i) a Black Sea clade and (ii) a well-supported clade grouping individuals from the Caspian and Azov Seas. Absence of shared haplotypes argues against either recent or human-mediated exchanges between Caspian and Azov Seas. A mismatch distribution analysis supports more stable population demography in the Caspian than in the Black Sea populations. Morphological divergence largely followed patterns of genetic divergence: our analyses grouped samples according to the basin of origin and corroborated the close phylogenetic affinity between Caspian and Azov Sea lineages. Altogether, our results highlight the necessity of careful (group-specific) evaluation of evolutionary trajectories in marine taxa that should certainly not be inferred from the current geographical proximity of sea basins alone. (C) 2013 Elsevier Inc. All rights reserved.
Philippine hornbills of the genera Aceros and Penelopides (Bucerotidae) are known to possess a large tandemly duplicated fragment in their mitochondrial genome, whose paralogous parts largely evolve in concert. In the present study, we surveyed the two distinguishable duplicated control regions in several individuals of the Luzon Tarictic Hornbill Penelopides manillae, compare their characteristics within and across individuals, and report on an intraspecific mitochondrial gene rearrangement found in one single specimen, i.e., an interchange between the two control regions. To our knowledge, this is the first observation of two distinct mitochondrial genome rearrangements within a bird species. We briefly discuss a possible evolutionary mechanism responsible for this pattern, and highlight potential implications for the application of control region sequences as a marker in population genetics and phylogeography.
The lively debate about speciation currently focuses on the relative importance of factors driving population differentiation. While many studies are increasingly producing results on the importance of selection, little is known about the interaction between drift and selection. Moreover, there is still little knowledge on the spatial-temporal scales at which speciation occurs, that is, arrangement of habitat patches, abruptness of habitat transitions, climate and habitat changes interacting with selective forces. To investigate these questions, we quantified variation on a fine geographical scale analysing morphological (shell) and genetic data sets coupled with environmental data in the land snail Murella muralis, endemic to the Mediterranean island of Sicily. Analysis of a fragment of the mitochondrial DNA cytochrome oxidase I gene (COI) and eight nuclear microsatellite loci showed that genetic variation is highly structured at a very fine spatial scale by local palaeogeographical events and historical population dynamics. Molecular clock estimates, calibrated here specifically for Tyrrhenian land snails, provided a framework of palaeogeographical events responsible for the observed geographical variations and migration routes. Finally, we showed for the first time well-documented lines of evidence of selection in the past, which explains divergence of land snail shell shapes. We suggest that time and palaeogeographical history acted as constraints in the progress along the ecological speciation continuum. Our study shows that testing for correlation among palaeogeography, morphology and genetic data on a fine geographical scale provides information fundamental for a detailed understanding of ecological speciation processes.
Introduction: We examined patterns of genetic divergence in 26 Mediterranean populations of the semi-terrestrial beachflea Orchestia montagui using mitochondrial (cytochrome oxidase subunit I), microsatellite (eight loci) and allozymic data. The species typically forms large populations within heaps of dead seagrass leaves stranded on beaches at the waterfront. We adopted a hierarchical geographic sampling to unravel population structure in a species living at the sea-land transition and, hence, likely subjected to dramatically contrasting forces.
Results: Mitochondrial DNA showed historical phylogeographic breaks among Adriatic, Ionian and the remaining basins (Tyrrhenian, Western and Eastern Mediterranean Sea) likely caused by the geological and climatic changes of the Pleistocene. Microsatellites (and to a lesser extent allozymes) detected a further subdivision between and within the Western Mediterranean and the Tyrrhenian Sea due to present-day processes. A pattern of isolation by distance was not detected in any of the analyzed data set.
Conclusions: We conclude that the population structure of O. montagui is the result of the interplay of two contrasting forces that act on the species population genetic structure. On one hand, the species semi-terrestrial life style would tend to determine the onset of local differences. On the other hand, these differences are partially counter-balanced by passive movements of migrants via rafting on heaps of dead seagrass leaves across sites by sea surface currents. Approximate Bayesian Computations support dispersal at sea as prevalent over terrestrial regionalism.
Milinkovitch, Michel C. ; Kanitz, Ricardo ; Tiedemann, Ralph ; Tapia, Washington ; Llerena, Fausto ; Caccone, Adalgisa ; Gibbs, James P. ; Powell, Jeffrey R.
A species of Galapagos tortoise endemic to Espanola Island was reduced to just 12 females and three males that have been bred in captivity since 1971 and have produced over 1700 offspring now repatriated to the island. Our molecular genetic analyses of juveniles repatriated to and surviving on the island indicate that none of the tortoises sampled in 1994 had hatched on the island versus 3% in 2004 and 24% in 2007, which demonstrates substantial and increasing reproduction in situ once again. This recovery occurred despite the parental population having an estimated effective population size <8 due to a combination of unequal reproductive success of the breeders and nonrandom mating in captivity. These results provide guidelines for adapting breeding regimes in the parental captive population and decreasing inbreeding in the repatriated population. Using simple morphological data scored on the sampled animals, we also show that a strongly heterogeneous distribution of tortoise sizes on Espanola Island observed today is due to a large variance in the number of animals included in yearly repatriation events performed in the last 40years. Our study reveals that, at least in the short run, some endangered species can recover dramatically despite a lack of genetic variation and irregular repatriation efforts.
Über die Autoren
(2013)
The correction of software failures tends to be very cost-intensive because their debugging is an often time-consuming development activity. During this activity, developers largely attempt to understand what causes failures: Starting with a test case that reproduces the observable failure they have to follow failure causes on the infection chain back to the root cause (defect). This idealized procedure requires deep knowledge of the system and its behavior because failures and defects can be far apart from each other. Unfortunately, common debugging tools are inadequate for systematically investigating such infection chains in detail. Thus, developers have to rely primarily on their intuition and the localization of failure causes is not time-efficient. To prevent debugging by disorganized trial and error, experienced developers apply the scientific method and its systematic hypothesis-testing. However, even when using the scientific method, the search for failure causes can still be a laborious task. First, lacking expertise about the system makes it hard to understand incorrect behavior and to create reasonable hypotheses. Second, contemporary debugging approaches provide no or only partial support for the scientific method. In this dissertation, we present test-driven fault navigation as a debugging guide for localizing reproducible failures with the scientific method. Based on the analysis of passing and failing test cases, we reveal anomalies and integrate them into a breadth-first search that leads developers to defects. This systematic search consists of four specific navigation techniques that together support the creation, evaluation, and refinement of failure cause hypotheses for the scientific method. First, structure navigation localizes suspicious system parts and restricts the initial search space. Second, team navigation recommends experienced developers for helping with failures. Third, behavior navigation allows developers to follow emphasized infection chains back to root causes. Fourth, state navigation identifies corrupted state and reveals parts of the infection chain automatically. We implement test-driven fault navigation in our Path Tools framework for the Squeak/Smalltalk development environment and limit its computation cost with the help of our incremental dynamic analysis. This lightweight dynamic analysis ensures an immediate debugging experience with our tools by splitting the run-time overhead over multiple test runs depending on developers’ needs. Hence, our test-driven fault navigation in combination with our incremental dynamic analysis answers important questions in a short time: where to start debugging, who understands failure causes best, what happened before failures, and which state properties are infected.
Soft Power ist zu einem einflussreichen Konzept avanciert – in der Politikwissenschaft, aber auch in der Politik selbst. Dabei bleibt es sowohl theoretisch als auch praktisch umstritten. In der Praxis wird das Konzept instrumentalisiert, um außenpolitisches Handeln von militärischem und wirtschaftlichem Druck positiv abzugrenzen. Unklar ist, wie Soft Power in militärischen Kontexten, in denen Hard Power im Vordergrund steht, funktionieren kann. Anhand des Afghanistan-Einsatzes der Bundeswehr wird dieses Verhältnis analysiert und eine eigene Definition von Soft Power entwickelt.
The nutrient exchange between plant and fungus is the key element of the arbuscular mycorrhizal (AM) symbiosis. The fungus improves the plant’s uptake of mineral nutrients, mainly phosphate, and water, while the plant provides the fungus with photosynthetically assimilated carbohydrates. Still, the knowledge about the mechanisms of the nutrient exchange between the symbiotic partners is very limited. Therefore, transport processes of both, the plant and the fungal partner, are investigated in this study. In order to enhance the understanding of the molecular basis underlying this tight interaction between the roots of Medicago truncatula and the AM fungus Rhizophagus irregularis, genes involved in transport processes of both symbiotic partners are analysed here. The AM-specific regulation and cell-specific expression of potential transporter genes of M. truncatula that were found to be specifically regulated in arbuscule-containing cells and in non-arbusculated cells of mycorrhizal roots was confirmed. A model for the carbon allocation in mycorrhizal roots is suggested, in which carbohydrates are mobilized in non-arbusculated cells and symplastically provided to the arbuscule-containing cells. New insights into the mechanisms of the carbohydrate allocation were gained by the analysis of hexose/H+ symporter MtHxt1 which is regulated in distinct cells of mycorrhizal roots. Metabolite profiling of leaves and roots of a knock-out mutant, hxt1, showed that it indeed does have an impact on the carbohydrate balance in the course of the symbiosis throughout the whole plant, and on the interaction with the fungal partner. The primary metabolite profile of M. truncatula was shown to be altered significantly in response to mycorrhizal colonization. Additionally, molecular mechanisms determining the progress of the interaction in the fungal partner of the AM symbiosis were investigated. The R. irregularis transcriptome in planta and in extraradical tissues gave new insight into genes that are differentially expressed in these two fungal tissues. Over 3200 fungal transcripts with a significantly altered expression level in laser capture microdissection-collected arbuscules compared to extraradical tissues were identified. Among them, six previously unknown specifically regulated potential transporter genes were found. These are likely to play a role in the nutrient exchange between plant and fungus. While the substrates of three potential MFS transporters are as yet unknown, two potential sugar transporters are might play a role in the carbohydrate flow towards the fungal partner. In summary, this study provides new insights into transport processes between plant and fungus in the course of the AM symbiosis, analysing M. truncatula on the transcript and metabolite level, and provides a dataset of the R. irregularis transcriptome in planta, providing a high amount of new information for future works.
A detailed description of the characteristics of antimicrobial peptides (AMPs) is highly demanded, since the resistance against traditional antibiotics is an emerging problem in medicine. They are part of the innate immune system in every organism, and they are very efficient in the protection against bacteria, viruses, fungi and even cancer cells. Their advantage is that their target is the cell membrane, in contrast to antibiotics which disturb the metabolism of the respective cell type. This allows AMPs to be more active and faster. The lack of an efficient therapy for some cancer types and the evolvement of resistance against existing antitumor agents make AMPs promising in cancer therapy besides being an alternative to traditional antibiotics. The aim of this work was the physical-chemical characterization of two fragments of LL-37, a human antimicrobial peptide from the cathelicidin family. The fragments LL-32 and LL-20 exhibited contrary behavior in biological experiments concerning their activity against bacterial cells, human cells and human cancer cells. LL-32 had even a higher activity than LL-37, while LL-20 had almost no effect. The interaction of the two fragments with model membranes was systematically studied in this work to understand their mode of action. Planar lipid films were mainly applied as model systems in combination with IR-spectroscopy and X-ray scattering methods. Circular Dichroism spectroscopy in bulk systems completed the results. In the first approach, the structure of the peptides was determined in aqueous solution and compared to the structure of the peptides at the air/water interface. In bulk, both peptides are in an unstructured conformation. Adsorbed and confined to at the air-water interface, the peptides differ drastically in their surface activity as well as in the secondary structure. While LL-32 transforms into an α-helix lying flat at the water surface, LL-20 stays partly unstructured. This is in good agreement with the high antimicrobial activity of LL-32. In the second approach, experiments with lipid monolayers as biomimetic models for the cell membrane were performed. It could be shown that the peptides fluidize condensed monolayers of negatively charged DPPG which can be related to the thinning of a bacterial cell membrane. An interaction of the peptides with zwitterionic PCs, as models for mammalian cells, was not clearly observed, even though LL-32 is haemolytic. In the third approach, the lipid monolayers were more adapted to the composition of human erythrocyte membranes by incorporating sphingomyelin (SM) into the PC monolayers. Physical-chemical properties of the lipid films were determined and the influence of the peptides on them was studied. It could be shown that the interaction of the more active LL-32 is strongly increased for heterogeneous lipid films containing both gel and fluid phases, while the interaction of LL-20 with the monolayers was unaffected. The results indicate an interaction of LL-32 with the membrane in a detergent-like way. Additionally, the modelling of the peptide interaction with cancer cells was performed by incorporating some negatively charged lipids into the PC/SM monolayers, but the increased charge had no effect on the interaction of LL-32. It was concluded, that the high anti-cancer activity of the peptide originates from the changed fluidity of cell membrane rather than from the increased surface charge. Furthermore, similarities to the physical-chemical properties of melittin, an AMP from the bee venom, were demonstrated.
Kindliche Aphasie
(2013)
1. Introduction 2. Analysis of implementation of the Basel III in China 2.1 Implementation of capital adequacy rules 2.2 Implementation of leverage ratio rules 2.3 Implementation of liquidity management rules 3. Suggestions for further development of China’s banking industry 3.1 Promoting capital structure adjustment and broadening capital supplement channels 3.2 Transforming business models and developing intermediary and off-balance business 3.3 Increasing the intensity of risk management and refining its standards
1. Introduction 2. The growth of China’s SMBs and the changes of the banking market structure – a land of small- and medium-sized companies 2.1 The characteristics of China’s banking market structure 2.2 The growth of China’s SMBs 2.3 The changes of China’s banking market structure 3. The opportunities and challenges facing SMBs in China 3.1 Opportunities 3.2 Challenges 4. Conclusion
Die Idee für den Workshop war entstanden im Rahmen der Nachwuchstagung Judaistik/Jüdische Studien der Vereinigung für Jüdische Studien e. V., die im Februar 2012 in Bamberg stattgefunden hatte. Dort äußerte sich ein großer Bedarf nach größerer überregionaler Vernetzung. Als sehr wünschenswert wurde festgehalten, in Ergänzung zur Nachwuchstagung auch regelmäßige Treffen in kleineren Arbeitsgruppen zu etablieren. Der Workshop in Veitshöchheim war die erste Veranstaltung, die diese Idee zeitnah, acht Monate nach der Nachwuchstagung, umsetzte. Der Workshop fand in Kooperation zwischen der Vereinigung für Jüdische Studien mit dem Lehrstuhl für fränkische Landesgeschichte an der Universität Würzburg statt.
Rezensiertes Werk: von der Krone, Kerstin: Wissenschaft in Öffentlichkeit. Die Wissenschaft des Judentums und ihre Zeitschriften. - Berlin: de Gruyter 2012. X, 539 S. - (=Studia Judaica, Bd. 65) Thulin, Mirjam: Kaufmanns Nachrichtendienst. Ein jüdisches Gelehrtennetzwerk im 19. Jahrhundert. - Göttingen: vandenhoeck & Ruprecht 2012. 424 S., 14 Abb., 6 Karten, 6 Tabellen. - (=Schriften des Simon-Dubnow-Instituts, Bd.16)
Rezensiertes Werk: Timm, Erika; Birnbaum, Eleazar und Birnbaum, David(Hg.): Ein Leben für die Wissenschaft/A Lifetime of Achievement. Wissenschaftliche Aufsätze aus sechs Jahrzehnten von Salomo A. Birnbaum/Six Decades of Scholarly Articles by Solomon A. Birnbaum. 2 Bde. - Berlin – Boston: De Gruyter 2011. Band 1, 540 S., Band 2. XXVII, 458 S.
Diet is a major force influencing the intestinal microbiota. This is obvious from drastic changes in microbiota composition after a dietary alteration. Due to the complexity of the commensal microbiota and the high inter-individual variability, little is known about the bacterial response at the cellular level. The objective of this work was to identify mechanisms that enable gut bacteria to adapt to dietary factors. For this purpose, germ-free mice monoassociated with the commensal Escherichia coli K-12 strain MG1655 were fed three different diets over three weeks: a diet rich in starch, a diet rich in non-digestible lactose and a diet rich in casein. Two dimensional gel electrophoresis and electrospray tandem mass spectrometry were applied to identify differentially expressed proteins of E. coli recovered from small intestine and caecum of mice fed the lactose or casein diets in comparison with those of mice fed the starch diet. Selected differentially expressed bacterial proteins were characterised in vitro for their possible roles in bacterial adaptation to the various diets. Proteins belonging to the oxidative stress regulon oxyR such as alkyl hydroperoxide reductase subunit F (AhpF), DNA protection during starvation protein (Dps) and ferric uptake regulatory protein (Fur), which are required for E. coli’s oxidative stress response, were upregulated in E. coli of mice fed the lactose-rich diet. Reporter gene analysis revealed that not only oxidative stress but also carbohydrate-induced osmotic stress led to the OxyR-dependent expression of ahpCF and dps. Moreover, the growth of E. coli mutants lacking the ahpCF or oxyR genes was impaired in the presence of non-digestible sucrose. This indicates that some OxyR-dependent proteins are crucial for the adaptation of E. coli to osmotic stress conditions. In addition, the function of two so far poorly characterised E. coli proteins was analysed: 2 deoxy-D gluconate 3 dehydrogenase (KduD) was upregulated in intestinal E. coli of mice fed the lactose-rich diet and this enzyme and 5 keto 4 deoxyuronate isomerase (KduI) were downregulated on the casein-rich diet. Reporter gene analysis identified galacturonate and glucuronate as inducers of the kduD and kduI gene expression. Moreover, KduI was shown to facilitate the breakdown of these hexuronates, which are normally degraded by uronate isomerase (UxaC), altronate oxidoreductase (UxaB), altronate dehydratase (UxaA), mannonate oxidoreductase (UxuB) and mannonate dehydratase (UxuA), whose expression was repressed by osmotic stress. The growth of kduID-deficient E. coli on galacturonate or glucuronate was impaired in the presence of osmotic stress, suggesting KduI and KduD to compensate for the function of the regular hexuronate degrading enzymes under such conditions. This indicates a novel function of KduI and KduD in E. coli’s hexuronate metabolism. Promotion of the intracellular formation of hexuronates by lactose connects these in vitro observations with the induction of KduD on the lactose-rich diet. Taken together, this study demonstrates the crucial influence of osmotic stress on the gene expression of E. coli enzymes involved in stress response and metabolic processes. Therefore, the adaptation to diet-induced osmotic stress is a possible key factor for bacterial colonisation of the intestinal environment.
A method is presented of acquiring the principles of three sorting algorithms through developing interactive applications in Excel.
Problem solving is one of the central activities performed by computer scientists as well as by computer science learners. Whereas the teaching of algorithms and programming languages is usually well structured within a curriculum, the development of learners’ problem-solving skills is largely implicit and less structured. Students at all levels often face difficulties in problem analysis and solution construction. The basic assumption of the workshop is that without some formal instruction on effective strategies, even the most inventive learner may resort to unproductive trial-and-error problemsolving processes. Hence, it is important to teach problem-solving strategies and to guide teachers on how to teach their pupils this cognitive tool. Computer science educators should be aware of the difficulties and acquire appropriate pedagogical tools to help their learners gain and experience problem-solving skills.