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Objective Depression after stroke and myocardial infarction (MI) is common but often assumed to be undertreated without reliable evidence being available. Thus, we aimed to determine treatment rates and investigate the application of guidelines in these conditions. Methods Databases MEDLINE, EMBASE, PsycInfo, Web of Science, CINAHL, and Scopus were systematically searched without language restriction from inception to June 30, 2017. Prospective observational studies with consecutive recruitment reporting any antidepressant treatment in adults with depression after stroke or MI were included. Random-effects models were used to calculate pooled estimates of treatment rates. Results Fifty-five studies reported 32 stroke cohorts (n = 8938; pooled frequency of depression = 34%, 95% confidence interval [CI] = 29%-38%) and 17 MI cohorts (n = 10,767; pooled frequency of depression = 24%, 95% CI = 20%-28%). In 29 stroke cohorts, 24% (95% CI = 20%-27%) of 2280 depressed people used antidepressant medication. In 15 MI cohorts, 14% (95% CI = 8%-19%) of 2381 depressed people used antidepressant medication indicating a lower treatment rate than in stroke. Two studies reported use of psychosocial interventions, indicating that less than 10% of participants were treated. Conclusions Despite the high frequency of depression after stroke and MI and the existence of efficacious treatment strategies, people often remain untreated. Innovative strategies are needed to increase the use of effective antidepressive interventions in patients with cardiovascular disease.
The variation of Rayleigh ellipticity versus frequency is gaining popularity in site characterization. It becomes a necessary observable to complement dispersion curves when inverting shear wave velocity profiles. Various methods have been proposed so far to extract polarization from ambient vibrations recorded on a single three-component station or with an array of three-component sensors. If only absolute values were recovered 10 yr ago, new array-based techniques were recently proposed with enhanced efficiencies providing also the ellipticity sign. With array processing, higher-order modes are often detected even in the ellipticity domain. We suggest to explore the properties of a high-resolution beamforming where radial and vertical components are explicitly included. If N is the number of three-component sensors, 2N x 2N cross-spectral density matrices are calculated for all presumed directions of propagation. They are built with N radial and N vertical channels. As a first approach, steering vectors are designed to fit with Rayleigh wave properties: the phase shift between radial and vertical components is either -Pi/2 or Pi/2. We show that neglecting the ellipticity tilt due to attenuation has only minor effects on the results. Additionally, we prove analytically that it is possible to retrieve the ellipticity value from the usual maximization of the high-resolution beam power. The method is tested on synthetic data sets and on experimental data. Both are reference sites already analysed by several authors. A detailed comparison with previous results on these cases is provided.
Für die Analyse der Unterrichtsqualität von Schulen durch Schülerurteile sollten drei Voraussetzungen erfüllt sein: (1) eine angemessene Übereinstimmung der Schülerurteile innerhalb der Schulen, (2) systematische Variabilität der Schülerurteile zwischen Schulen, (3) ein ausreichendes Maß an Reliabilität der aggregierten Urteile. Diese Studie untersucht mit internationalen PISA-Daten (Zyklen 2000–2012; 81 Länder, über 55.300 Schulen, über 1,3 Millionen 15-Jährige), inwiefern dies für Indikatoren der Qualitätsdimensionen des Unterrichts (Klassenführung, Kognitive Aktivierung, Konstruktive Unterstützung) zutrifft. Dafür bestimmten wir das Übereinstimmungsmaß rWG(J) sowie die Intraklassenkorrelationen ICC(1) und ICC(2). Es zeigte sich, dass (1) die Mehrzahl der Unterrichtsmerkmale eine moderate oder starke Übereinstimmung in Schulen aufwies, (2) sich Unterrichtsmerkmale aus Sicht der Schülerschaft systematisch zwischen Schulen unterschieden, jedoch (3) die Reliabilität der aggregierten Schülerurteile in vielen Ländern nicht ausreichte. Die Ergebnisse diskutieren wir vor dem Hintergrund von Konventionen zur Beurteilung der Übereinstimmung, Variabilität und Reliabilität auf Schulebene.
We present a new precision measurement of gas-phase abundances of S, O, N, Si, Fe, P, Al, Ca as well as molecular hydrogen (H-2) in the Leading Arm (region II, LA II) of the Magellanic Stream (MS) toward the Seyfert galaxy NGC 3783. The results are based on high-quality archival ultraviolet/optical/radio data from various different instruments (HST/STIS, FUSE, AAT, GBT, GB140 ft, ATCA). Our study updates previous results from lower-resolution data and provides for the first time a self-consistent component model of the complex multiphase absorber, delivering important constraints on the nature and origin of LA II. We derive a uniform, moderate a abundance in the two main absorber groups at +245 and +190 km s(-1) of alpha/H = 0.30 +/- 0.05 solar, a low nitrogen abundance of N/H = 0.05 +/- 0.01 solar, and a high dust content with substantial dust depletion values for Si, Fe, Al, and Ca. These a, N, and dust abundances in LA II are similar to those observed in the Small Magellanic Cloud (SMC). From the analysis of the H2 absorption, we determine a high thermal pressure of P/k approximate to 1680 K cm(-3) in LA II, in line with the idea that LA II is located in the inner Milky Way halo at a z-height of < 20 kpc, where it hydrodynamically interacts with the ambient hot coronal gas. Our study supports a scenario in which LA II stems from the breakup of a metal- and dust-enriched progenitor cloud that was recently (200-500 Myr ago) stripped from the SMC.
Full water splitting into hydrogen and oxygen on semiconductor nanocrystals is a challenging task; overpotentials must be overcome for both half-reactions and different catalytic sites are needed to facilitate them. Additionally, efficient charge separation and prevention of back reactions are necessary. Here, we report simultaneous H-2 and O-2 evolution by CdS nanorods decorated with nanoparticulate reduction and molecular oxidation co-catalysts. The process proceeds entirely without sacrificial agents and relies on the nanorod morphology of CdS to spatially separate the reduction and oxidation sites. Hydrogen is generated on Pt nanoparticles grown at the nanorod tips, while Ru(tpy)(bpy)Cl-2-based oxidation catalysts are anchored through dithiocarbamate bonds onto the sides of the nanorod. O-2 generation from water was verified by O-18 isotope labelling experiments, and time-resolved spectroscopic results confirmed efficient charge separation and ultrafast electron and hole transfer to the reaction sites. The system demonstrates that combining nanoparticulate and molecular catalysts on anisotropic nanocrystals provides an effective pathway for visible-light-driven photocatalytic water splitting.
What is the underlying diffusion process governing the spreading dynamics and search strategies employed by amoeboid cells? Based on the statistical analysis of experimental single-cell tracking data of the two-dimensional motion of the Dictyostelium discoideum amoeboid cells, we quantify their diffusive behaviour based on a number of standard and complementary statistical indicators. We compute the ensemble- and time-averaged mean-squared displacements (MSDs) of the diffusing amoebae cells and observe a pronounced spread of short-time diffusion coefficients and anomalous MSD-scaling exponents for individual cells. The distribution functions of the cell displacements, the long-tailed distribution of instantaneous speeds, and the velocity autocorrelations are also computed. In particular, we observe a systematic superdiffusive short-time behaviour for the ensemble- and time-averaged MSDs of the amoeboid cells. Also, a clear anti-correlation of scaling exponents and generalised diffusivity values for different cells is detected. Most significantly, we demonstrate that the distribution function of the cell displacements has a strongly non-Gaussian shape andusing a rescaled spatio-temporal variablethe cell-displacement data collapse onto a universal master curve. The current analysis of single-cell motions can be implemented for quantifying diffusive behaviours in other living-matter systems, in particular, when effects of active transport, non-Gaussian displacements, and heterogeneity of the population are involved in the dynamics.
Woodlands and steppes
(2018)
Based on fossil organism remains including plant macrofossils, charcoal, pollen, and invertebrates preserved in syngenetic deposits of the Batagay permafrost sequence in the Siberian Yana Highlands, we reconstructed the environmental history during marine isotope stages (MIS) 6 to 2. Two fossil assemblages, exceptionally rich in plant remains, allowed for a detailed description of the palaeo-vegetation during two climate extremes of the Late Pleistocene, the onset of the last glacial maximum (LGM) and the last interglacial. In addition, altogether 41 assemblages were used to outline the vegetation history since the penultimate cold stage of MIS 6. Accordingly, meadow steppes analogue to modern communities of the phytosociological order Festucetalia lenensis formed the primary vegetation during the Saalian and Weichselian cold stages. Cold-resistant tundra-steppe communities (Carici rupestris-Kobresietea bellardii) as they occur above the treeline today were, in contrast to more northern locations, mostly lacking. During the last interglacial, open coniferous woodland similar to modern larch taiga was the primary vegetation at the site. Abundant charcoal indicates wildfire events during the last interglacial. Zoogenic disturbances of the local vegetation were indicated by the presence of ruderal plants, especially by abundant Urtica dioica, suggesting that the area was an interglacial refugium for large herbivores. Meadow steppes, which formed the primary vegetation during cold stages and provided potentially suitable pastures for herbivores, were a significant constituent of the plant cover in the Yana Highlands also under the full warm stage conditions of the last interglacial. Consequently, meadow steppes occurred in the Yana Highlands during the entire investigated timespan from MIS 6 to MIS 2 documenting a remarkable environmental stability. Thus, the proportion of meadow steppe vegetation merely shifted in response to the respectively prevailing climatic conditions. Their persistence indicates low precipitation and a relatively warm growing season throughout and beyond the late Pleistocene. The studied fossil record also proves that modern steppe occurrences in the Yana Highlands did not establish as late as in the Holocene but instead are relicts of a formerly continuous steppe belt extending from Central Siberia to Northeast Yakutia during the Pleistocene. The persistence of plants and invertebrates characteristic of meadow steppe vegetation in interior Yakutia throughout the late Quaternary indicates climatic continuity and documents the suitability of this region as a refugium also for other organisms of the Pleistocene mammoth steppe including the iconic large herbivores. (C)2018 Elsevier Ltd. All rights reserved.
Trees control the flowering processes in response to both environmental and endogenous (mechanisms at cellular/tissue level) conditions. Dormancy of flower buds is characterized by the reduction of growth and the enhancement of frost and desiccation resistance. The release of endodormancy and the beginning of ontogenetic development, as two important dates for developing reliable phenological models, escape from any visible signs. Thus, we identified - to our knowledge as first - relevant proteins in sweet cherry buds occurring during these phenological phases at high time resolution in three seasons (2012/13–2014/15) under natural conditions in Northeast Germany. The protein content of buds from the first week of October to leaf fall, from leaf fall to the end of endodormancy (t1), from t1 to the beginning of ontogenetic development (t1*), and from t1* until swollen bud, was comparable in each of the seasons. The increase of the protein content began after swollen bud and markedly differences occurred at side green, green tip, tight and open cluster. SDS gel electrophoresis followed by peptide mass fingerprinting accomplished by MALDI-TOF MS was applied for protein identification. ‘Volume intensity’ has been used to demonstrate the pattern and changes of proteins. None of the analysed proteins like for cell proliferation/differentiation (Phytosulfokines 3), carbon fixation (Rubisco), and defense against pathogenes (Major allergen Pru sv 1) indicates the date of endodormancy release or the beginning of the (invisible) ontogenetic development. The stages around green tip, tight, and open cluster resulted in markedly increase of the volume intensity of the protein for cell proliferation/differentiation and the carbon fixation, whereas the volume intensity of a protein for defense against pathogens markedly decreased. The pattern and changes of the volume intensity of neoxanthin synthase (NXS) in sweet cherry buds followed the increasing demand during endo- and ecodormancy to produce neoxanthin, which is a prominent member of the group of reactive oxygen species (ROS) scavengers.
Both enstatite spectra are very bright in the VIS and NIR and show almost neutral to slightly bluish spectral slopes with a steep absorption in the UV. Very low iron in the enstatites (below similar to 0.04 wt% FeO) already results in weak albeit noticeable absorptions in the VNIR between 0.4 and 0.9 mu m. Orthoenstatite and clinoenstatite are not distinguishable based only on their spectra in the VIS and NIR. At the Reststrahlen bands in the MIR a systematic difference in the number and exact position of local minima at similar to 10 mu m between clinoenstatite and orthoenstatite is evident. This can be used to discern between the polymorphs in this wavelength range. Additionally, we can distinguish between Fe-free low- and high-Ca pyroxenes in the MIR.
The use of functional music in gait training termed rhythmic auditory stimulation (RAS) and treadmill training (TT) have both been shown to be effective in stroke patients (SP). The combination of RAS and treadmill training (RAS-TT) has not been clinically evaluated to date. The aim of the study was to evaluate the efficacy of RAS-TT on functional gait in SR The protocol followed the design of an explorative study with a rater-blinded three arm prospective randomized controlled parallel group design. Forty-five independently walking SP with a hemiparesis of the lower limb or an unsafe and asymmetrical walking pattern were recruited. RAS-TT was carried out over 4 weeks with TT and neurodevelopmental treatment based on Bobath approach (NDT) serving as control interventions. For RAS-TT functional music was adjusted individually while walking on the treadmill. Pre and post-assessments consisted of the fast gait speed test (FGS), a gait analysis with the locometre (LOC), 3 min walking time test (3MWT), and an instrumental evaluation of balance (IEB). Raters were blinded to group assignments. An analysis of covariance (ANCOVA) was performed with affiliated measures from pre-assessment and time between stroke and start of study as covariates. Thirty-five participants (mean age 63.6 +/- 8.6 years, mean time between stroke and start of study 42.1 +/- 23.7 days) completed the study (11 RAS-TT, 13 TT, 11 NDT). Significant group differences occurred in the FGS for adjusted post-measures in gait velocity [F-(2,F- (34)) = 3.864, p = 0.032; partial eta(2) = 0.205] and cadence [F-(2,F- 34) = 7.656, p = 0.002; partial eta(2) = 0.338]. Group contrasts showed significantly higher values for RAS-TT. Stride length results did not vary between the groups. LOC, 3MWT, and IEB did not indicate group differences. One patient was withdrawn from TT because of pain in one arm. The study provides first evidence for a higher efficacy of RAS-TT in comparison to the standard approaches TT and NDT in restoring functional gait in SP. The results support the implementation of functional music in neurological gait rehabilitation and its use in combination with treadmill training.
Given two weighted graphs (X, b(k), m(k)), k = 1, 2 with b(1) similar to b(2) and m(1) similar to m(2), we prove a weighted L-1-criterion for the existence and completeness of the wave operators W-+/- (H-2, H-1, I-1,I-2), where H-k denotes the natural Laplacian in l(2)(X, m(k)) w.r.t. (X, b(k), m(k)) and I-1,I-2 the trivial identification of l(2)(X, m(1)) with l(2) (X, m(2)). In particular, this entails a general criterion for the absolutely continuous spectra of H-1 and H-2 to be equal.
We present the first high-resolution trace element (Mg/Ca, Sr/Ca, Ba/Ca) record from a stalagmite in southwestern Romania covering the last 3.6 ka, which provides the potential for quantitative climate reconstruction. Precise age control is based on three independent dating methods, in particular for the last 250 yr, where chemical lamina counting is combined with the identification of the 20th century radiocarbon bomb peak and Th-230/U dating. Long-term cave monitoring and model simulations of drip water and speleothem elemental variability indicate that precipitation-related processes are the main drivers of speleothem Mg/Ca ratios. Calibration against instrumental climate data shows a significant anti-correlation of speleothem Mg/Ca ratios with autumn/winter (October to March) precipitation (r = -0.61, p < 0.01), which is statistically robust when considering age uncertainties and auto-correlation. This relationship is used to develop a quantitative reconstruction of autumn/winter precipitation. During the late Holocene, our data suggest a heterogeneous pattern of past regional winter hydroclimate in the Carpathian/Balkan realm, along with intermittent weakening of the dominant influence of North Atlantic forcing. In agreement with other regional paleo-hydrological reconstructions, the observed variability reveals periodically occurring strong NW-SE hydro-climate gradients. We hypothesize, that this pattern is caused by shifts of the eastern edge of the area of influence of the NAO across central eastern Europe due to the confluence of North Atlantic forcing, and other climatic features such as the East Atlantic/Western Russia (EAWR) pattern. (C) 2018 Elsevier B.V. All rights reserved.
When knowing is believing
(2018)
In an effort to understand teachers' technology use, recent scholarship has explored the idea of technological pedagogical content knowledge (TPCK or TPACK). Many studies have used self-reports to measure this knowledge (SR TPCK). Several studies have examined the construct validity of these assessments by analysing the internal relationships of the knowledge domains, but little attention has been paid to how SR TPCK relates to external criteria. We tackled this question of discriminant validity by reanalysing 2 data sets. We used correlation and multiple regression analyses to explore whether conceptually related constructs explain any variance in participants' SR TPCK. In Study 1, we applied this strategy to German pre-service teachers using technology use, attitudinal variables, and objective measures of teachers' knowledge of technology and pedagogy as external criteria. In Study 2, we examined measures of technology knowledge, experience, and pro-technology beliefs for in-service teachers in the United States. Across both studies, a sizeable amount of the variance in SR TPCK is explained by teachers' prior technology use and pro-technology attitudes. In contrast, fact-based tests of technology and pedagogy are distinct from SR TPCK. We discuss implications for these findings and argue that researchers should gather complementary measures in concert.
Aims. We study the evolution of an arch filament system (AFS) and of its individual arch filaments to learn about the processes occurring in them. Methods. We observed the AFS at the GREGOR solar telescope on Tenerife at high cadence with the very fast spectroscopic mode of the GREGOR Infrared Spectrograph (GRIS) in the He I 10 830 angstrom spectral range. The He I triplet profiles were fitted with analytic functions to infer line-of-sight (LOS) velocities to follow plasma motions within the AFS. Results. We tracked the temporal evolution of an individual arch filament over its entire lifetime, as seen in the He I 10 830 angstrom triplet. The arch filament expanded in height and extended in length from 13 ' to 21 '. The lifetime of this arch filament is about 30 min. About 11 min after the arch filament is seen in He I, the loop top starts to rise with an average Doppler velocity of 6 km s(-1). Only two minutes later, plasma drains down with supersonic velocities towards the footpoints reaching a peak velocity of up to 40 km s(-1) in the chromosphere. The temporal evolution of He I 10 830 angstrom profiles near the leading pore showed almost ubiquitous dual red components of the He I triplet, indicating strong downflows, along with material nearly at rest within the same resolution element during the whole observing time.
Folding and Lipid Composition Determine Membrane Interaction of the Disordered Protein COR15A
(2018)
Plants from temperate climates, such as the model plant Arabidopsis thaliana, are challenged with seasonal low temperatures that lead to increased freezing tolerance in fall in a process termed cold acclimation. Among other adaptations, this involves the accumulation of cold-regulated (COR) proteins, such as the intrinsically disordered chloroplast-localized protein COR15A. Together with its close homolog COR15B, it stabilizes chloroplast membranes during freezing. COR15A folds into amphipathic alpha-helices in the presence of high concentrations of low-molecular-mass crowders or upon dehydration. Under these conditions, the (partially) folded protein binds peripherally to membranes. In our study, we have used coarse-grained molecular dynamics simulations to elucidate the details of COR15A-membrane binding and its effects on membrane structure and dynamics. Simulation results indicate that at least partial folding of COR15A and the presence of highly unsaturated galactolipids in the membranes are necessary for efficient membrane binding. The bound protein is stabilized on the membrane by interactions of charged and polar amino acids with galactolipid headgroups and by interactions of hydrophobic amino acids with the upper part of the fatty acyl chains. Experimentally, the presence of liposomes made from a mixture of lipids mimicking chloroplast membranes induces additional folding in COR15A under conditions of partial dehydration, in agreement with the simulation results.
Nearly 13,000 years ago, the warming trend into the Holocene was sharply interrupted by a reversal to near glacial conditions. Climatic causes and ecological consequences of the Younger Dryas (YD) have been extensively studied, however proxy archives from the Mediterranean basin capturing this period are scarce and do not provide annual resolution. Here, we report a hydroclimatic reconstruction from stable isotopes (delta O-18, delta C-13) in subfossil pines from southern France. Growing before and during the transition period into the YD (12 900-12 600 cal BP), the trees provide an annually resolved, continuous sequence of atmospheric change. Isotopic signature of tree sourcewater (delta O-18(sw)) and estimates of relative air humidity were reconstructed as a proxy for variations in air mass origin and precipitation regime. We find a distinct increase in inter-annual variability of sourcewater isotopes (delta O-18(sw)), with three major downturn phases of increasing magnitude beginning at 12 740 cal BP. The observed variation most likely results from an amplified intensity of North Atlantic (low delta O-18(sw)) versus Mediterranean (high delta O-18(sw)) precipitation. This marked pattern of climate variability is not seen in records from higher latitudes and is likely a consequence of atmospheric circulation oscillations at the margin of the southward moving polar front.
Forest and steppe communities in the Altai region of Central Asia are threatened by changing climate and anthropogenic pressure. Specifically, increasing drought and grazing pressure may cause collapses of moisture-demanding plant communities, particularly forests. Knowledge about past vegetation and fire responses to climate and land use changes may help anticipating future ecosystem risks, given that it has the potential to disclose mechanisms and processes that govern ecosystem vulnerability. We present a unique paleoecological record from the high-alpine Tsambagarav glacier in the Mongolian Altai that provides novel large-scale information on vegetation, fire and pollution with an exceptional temporal resolution and precision. Our palynological record identifies several late-Holocene boreal forest expansions, contractions and subsequent recoveries. Maximum forest expansions occurred at 3000-2800 BC, 2400-2100 BC, and 1900-1800 BC. After 1800 BC mixed boreal forest communities irrecoverably declined. Fires reached a maximum at 1600 BC, 200 years after the final forest collapse. Our multiproxy data suggest that burning peaked in response to dead biomass accumulation resulting from forest diebacks. Vegetation and fire regimes partly decoupled from climate after 1700 AD, when atmospheric industrial pollution began, and land use intensified. We conclude that moisture availability was more important than temperature for past vegetation dynamics, in particular for forest loss and steppe expansion. The past Mongolian Altai evidence implies that in the future forests of the Russian Altai may collapse in response to reduced moisture availability.
The Sierra Nevada de Santa Marta in NW Colombia is an isolated massif at the northernmost end of the Andes chain near the boundary with the Caribbean plate. Previous geologic mapping and K-Ar dating have shown that Jurassic plutonic and volcanic units make up a large part of the Santa Marta Massif (SMM). These rocks have been considered to be part of a Jurassic magmatic arc extending from NW Colombia to northern Chile, but without any geochemical basis for comparison. This paper reports on a geochemical and Sr-Nd-Pb isotope study of the Jurassic rocks in the SMM and provides 12 new U-Pb zircon ages from in-situ laser ICP-MS dating. The plutonic and volcanic units span a range from 45 to 78 wt.% SiO2, with a dominance of intermediate to felsic compositions with SiO2 > 57 wt.%. They classify as calc-alkaline, medium to high-K, metaluminous rocks with trace-element features typical for arc-derived magma series. In terms of their major and trace-element compositions, the SMM Jurassic units overlap with contemporary plutonic and volcanic rocks from other regions of the Central and Eastern Cordilleras of Colombia, and confirm an arc affinity. The new U-Pb ages range from 176 +/- 1 Ma to 192 +/- 2 Ma (n = 12), with most between 180 and 188 Ma (n = 7). The initial Sr isotope ratios (at 180 Ma) are between 0.7012 and 0.7071 (n = 29), with 3 outliers attributed to mobilization of Rb and/or Sr, Nearly all samples have negative( )epsilon Nd-(180) values between - 10.3 and 0.0 (n = 30), the two exceptions being only slightly positive (1.1 and 1.9). Measured Pb isotope ratios fall in a narrow range, with Pb-206/Pb-204 from 18.02 to 19.95, (207) Pb/(204) Pb from 15.56 to 15.67 and Pb-208/Pb-204 from 37.76 to 39.04 (n = 28). In the regional context of previous studies, these results confirm early Jurassic ages and an arc affinity for the widespread magmatism exposed in the eastern and northeastern Colombian Andes. We also note patterns in the distribution and composition of magmas. The magmatic activity in the Central Cordillera tends to be younger than in the Eastern Cordillera and is spatially more restricted to the vicinity of regional fault systems. In terms of composition, Jurassic igneous rocks in the Eastern Cordillera have systematically lower epsilon Nd-(180) values than those from the Central Cordillera, whereas the Pb isotope ratios overlap. We ascribe the Nd isotope variations to heterogeneity in the mantle source and/or degree of crustal contamination, whereas the Pb isotope ratios are crust-dominated and similar throughout the region. The spatio-temporal and compositional evolution of Jurassic magmatic rocks in the Northern Andes reflect the major plate kinematic readjustment between the Triassic and the Early Jurassic in the proto-Andean margin.