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Objective We propose a data-driven method to detect temporal patterns of disease progression in high-dimensional claims data based on gradient boosting with stability selection. Materials and methods We identified patients with chronic obstructive pulmonary disease in a German health insurance claims database with 6.5 million individuals and divided them into a group of patients with the highest disease severity and a group of control patients with lower severity. We then used gradient boosting with stability selection to determine variables correlating with a chronic obstructive pulmonary disease diagnosis of highest severity and subsequently model the temporal progression of the disease using the selected variables. Results We identified a network of 20 diagnoses (e.g. respiratory failure), medications (e.g. anticholinergic drugs) and procedures associated with a subsequent chronic obstructive pulmonary disease diagnosis of highest severity. Furthermore, the network successfully captured temporal patterns, such as disease progressions from lower to higher severity grades. Discussion The temporal trajectories identified by our data-driven approach are compatible with existing knowledge about chronic obstructive pulmonary disease showing that the method can reliably select relevant variables in a high-dimensional context. Conclusion We provide a generalizable approach for the automatic detection of disease trajectories in claims data. This could help to diagnose diseases early, identify unknown risk factors and optimize treatment plans.
A growing number of business processes can be characterized as knowledge-intensive. The ability to speed up the transfer of knowledge between any kind of knowledge carriers in business processes with AR techniques can lead to a huge competitive advantage, for instance in manufacturing. This includes the transfer of person-bound knowledge as well as externalized knowledge of physical and virtual objects. The contribution builds on a time-dependent knowledge transfer model and conceptualizes an adaptable, AR-based application. Having the intention to accelerate the speed of knowledge transfers between a manufacturer and an information system, empirical results of an experimentation show the validity of this approach. For the first time, it will be possible to discover how to improve the transfer among knowledge carriers of an organization with knowledge-driven information systems (KDIS). Within an experiment setting, the paper shows how to improve the quantitative effects regarding the quality and amount of time needed for an example manufacturing process realization by an adaptable KDIS.
As Industry 4.0 infrastructures are seen as highly evolutionary environment with volatile, and time-dependent workloads for analytical tasks, particularly the optimal dimensioning of IT hardware is a challenge for decision makers because the digital processing of these tasks can be decoupled from their physical place of origin. Flexible architecture models to allocate tasks efficiently with regard to multi-facet aspects and a predefined set of local systems and external cloud services have been proven in small example scenarios. This paper provides a benchmark of existing task realization strategies, composed of (1) task distribution and (2) task prioritization in a real-world scenario simulation. It identifies heuristics as superior strategies.
As part of the digitization, the role of artificial systems as new actors in knowledge-intensive processes requires to recognize them as a new form of knowledge bearers side by side with traditional knowledge bearers, such as individuals, groups, organizations. By now, artificial intelligence (AI) methods were used in knowledge management (KM) for knowledge discovery, for the reinterpreting of information, and recent works focus on the studying of different AI technologies implementation for knowledge management, like big data, ontology-based methods and intelligent agents [1]. However, a lack of holistic management approach is present, that considers artificial systems as knowledge bearers. The paper therefore designs a new kind of KM approach, that integrates the technical level of knowledge and manifests as Neuronal KM (NKM). Superimposing traditional KM approaches with the NKM, the Symbiotic Knowledge Management (SKM) is conceptualized furthermore, so that human as well as artificial kinds of knowledge bearers can be managed as symbiosis. First use cases demonstrate the new KM, NKM and SKM approaches in a proof-of-concept and exemplify their differences.