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Wild birds are considered a potential reservoir or a carrier of viral diseases and may therefore play a role in the epidemiology of economically important or zoonotic diseases. In 2001 and 2002, a survey with special emphasis oil virus isolation in migrating waders and some other birds were conducted. In one of the most important inland resting sites for migratory waterfowl, tracheal and cloacal swabs were collected from 465 waders representing 19 different species, and 165 other birds that were not captured on purpose. A total of 42 avian viruses were isolated, 34 of these were identified as paramyxoviruses (PMVs). The majority of isolates came from waders and wild ducks, and were characterized as PMV-1. In contrast, PMV-4 was found in wild ducks only, PMV-6 was mainly detected in wader species. Four avian influenza viruses (ATVs), belonging to H4 and H3 haemagglutinin subtype, were isolated from wild duck species. Furthermore, four reo-like viruses were isolated from one particular wader species for the first time. The majority of virus positive birds were < 1 year old and did not show any clinical symptoms. There was no evidence for the presence of West Nile virus in these birds. These results confirm that the restricted resting sites in Western Europe must be considered as important locations for the intra- and interspecies transmission of avian viruses
We analyse the relationship of longitudinal and transversal increment statistics measured in isotropic small- scale turbulence. This is done by means of the theory of Markov processes leading to a phenomenological Fokker - Planck equation for the two increments from which a generalized K arm an equation is derived. We discuss in detail the analysis and show that the estimated equation can describe the statistics of the turbulent cascade. A remarkable result is that the main differences between longitudinal and transversal increments can be explained by a simple rescaling symmetry, namely the cascade speed of the transverse increments is 1.5 times faster than that of the longitudinal increments. Small differences can be found in the skewness and in a higher order intermittency term. The rescaling symmetry is compatible with the Kolmogorov constants and the K arm an equation and gives new insight into the use of extended self- similarity (ESS) for transverse increments. Based on the results we propose an extended self-similarity for the transverse increments (ESST)
Ellipticity of operators on a manifold with edges can be treated in the framework of a calculus of 2 X 2-block matrix operators with trace and potential operators on the edges. The picture is similar to the pseudodifferential analysis of boundary-value problems. The extra conditions satisfy an analogue of the Shapiro-Lopatinskij condition, provided a topological obstruction for the elliptic edge-degenerate operator in the upper left corner vanishes; this is an analogue of a condition of Atiyah and Bott in boundary-value problems. In general, however, we need global projection data, similarly to global boundary conditions, known for Dirac operators or other geometric operators. The present paper develops a new calculus with global projection data for operators on manifolds with edges. In particular, we show the Fredholm property in a suitable scale of spaces and construct parametrices within the calculus
This study assessed the extent to which second-language learners are sensitive to phonetic information contained in visual cues when identifying a non-native phonemic contrast. In experiment 1, Spanish and Japanese learners of English were tested on their perception of a labial/labiodental consonant contrast in audio (A), visual (V), and audio-visual (AV) modalities. Spanish students showed better performance overall, and much greater sensitivity to visual cues than Japanese students. Both learner groups achieved higher scores in the A V than in the A test condition, thus showing evidence of audio-visual benefit. Experiment 2 examined the perception of the less visually-salient /1/-/r/ contrast in Japanese and Korean learners of English. Korean learners obtained much higher scores in auditory and audio- visual conditions than in the visual condition, while Japanese learners generally performed poorly in both modalities. Neither. group showed evidence of audio-visual benefit. These results show the impact of the language background of the learner and visual salience of the contrast on the use of visual cues for a non-native contrast. Significant correlations between scores in the auditory and visual conditions suggest that increasing auditory proficiency in identifying a non-native contrast is linked with an increasing proficiency in using visual cues to the contrast.
Polymeric electrophosphorescent LEDs with internal quantum efficiencies approaching unity have been fabricated. Such performance levels are previously unknown for OLEDs. The key to this success is redox chemically doped oxetane- crosslinkable hole-transporting layers with multilayer capability (see figure). They improve hole injection and act as electron-blocking layers, without the need to include exciton-or hole-blocking layers
Plant outward-rectifying K+ channels mediate K+ efflux from guard cells during stomatal closure and from root cells into the xylem for root-shoot allocation of potassium (K). Intriguingly, the gating of these channels depends on the extracellular K+ concentration, although the ions carrying the current are derived from inside the cell. This K+ dependence confers a sensitivity to the extracellular K+ concentration ([K+]) that ensures that the channels mediate K+ efflux only, regardless of the [K+] prevailing outside. We investigated the mechanism of K+-dependent gating of the K+ channel SKOR of Arabidopsis by site-directed mutagenesis. Mutations affecting the intrinsic K+ dependence of gating were found to cluster in the pore and within the sixth transmembrane helix (S6), identifying an 'S6 gating domain' deep within the membrane. Mapping the SKOR sequence to the crystal structure of the voltage-dependent K+ channel KvAP from Aeropyrum pernix suggested interaction between the S6 gating domain and the base of the pore helix, a prediction supported by mutations at this site. These results offer a unique insight into the molecular basis for a physiologically important K+-sensory process in plants
Objective Pre-eclampsia is a serious complication of pregnancy with high morbidity and mortality and an incidence of 3-5% in all pregnancies. Early prediction is still insufficient in clinical practice. Although most pre- eclamptic patients have pathological uterine perfusion in the second trimester, perfusion disturbance has a positive predictive accuracy (PPA) only of approximately 30%. Methods Non-invasive continuous blood pressure recordings were taken simultaneously via a finger cuff for 30 min. Time series of systolic as well as diastolic beat-to-beat pressure values were extracted to analyse heart rate and blood pressure variability and baroreflex sensitivity in 102 second- trimester pregnancies, to assess predictability for pre-eclampsia (n = 16). All women underwent Doppler investigations of the uterine arteries. Results We identified a combination of three variability and baroreflex parameters to best predict pre-eclampsia several weeks before clinical manifestation. The discriminant function of these three parameters classified patients with later pre-eclampsia with a sensitivity of 87.5%, a specificity of 83.7%, and a PPA of 50.0%. Combined with Doppler investigations of uterine arteries, PPA increased to 71.4%. Conclusions This technique of incorporating one-stop clinical assessment of uterine perfusion and variability parameters in the second trimester produces the most effective prediction of pre-eclampsia to date
The deterministic calculation of earthquake scenarios using complete waveform modelling plays an increasingly important role in estimating shaking hazard in seismically active regions. Here we apply 3-D numerical modelling of seismic wave propagation to M 6+ earthquake scenarios in the area of the Lower Rhine Embayment, one of the seismically most active regions in central Europe. Using a 3-D basin model derived from geology, borehole information and seismic experiments, we aim at demonstrating the strong dependence of ground shaking on hypocentre location and basin structure. The simulations are carried out up to frequencies of ca. 1 Hz. As expected, the basin structure leads to strong lateral variations in peak ground motion, amplification and shaking duration. Depending on source-basin-receiver geometry, the effects correlate with basin depth and the slope of the basin flanks; yet, the basin also affects peak ground motion and estimated shaking hazard thereof outside the basin. Comparison with measured seismograms for one of the earthquakes shows that some of the main characteristics of the wave motion are reproduced. Cumulating the derived seismic intensities from the three modelled earthquake scenarios leads to a predominantly basin correlated intensity distribution for our study area
The averaged dynamics of various two-phase systems in a high-frequency vibration field is studied theoretically. The continuum approach is applied to describe such systems as solid particle suspensions, emulsions, bubbly fluids, when the volume concentration of the disperse phase is small and gravity is insignificant. The dynamics of the disperse system is considered by means of the method of averaging, when the fast pulsation and slow averaged motion can be treated separately. Two averaged models for both nondeformable and deformable particles, when the compressibility of the disperse phase becomes important, are obtained. A criterion when the compressibility of bubbles cannot be neglected is figured out. For both cases the developed models are applied to study the averaged dynamics of the disperse media in an infinite plane layer under the action of transversal vibration. (C) 2006 American Institute of Physics
In planetary rings, binary collisions and mutual gravity are the predominant particle interactions. Based on a viscoelastic contact model we implement the concept of static adhesion. We discuss the collision dynamics and obtain a threshold velocity for restitution or agglomeration to occur. The latter takes place within a range of a few cm s(-1) for icy grains at low temperatures. The stability of such two-body agglomerates bound by adhesion and gravity in a tidal environment is discussed and applied to the saturnian system. A maximal agglomerate size for a given orbit location is obtained. In this way we are able to resolve the borderline of the zone where agglomerates can exist as a function of the agglomerate size and thus gain an alternative to the classical Roche limit. An increasing ring grain size with distance to Saturn as observed by the VIMS-experiment on board the Cassini spacecraft can be found by our estimates and implications for the saturnian system will be addressed.
The Mexican tetra Astyanax fasciatus has evolved a variety of more or less color- and eyeless cave populations. Here we examined the evolution of the female preference for large male body size within different populations of this species, either surface- or cave-dwelling. Given the choice between visual cues from a large and a small male, females from the surface form as well as females from an eyed cave form showed a strong preference for large males. When only non-visual cues were presented in darkness, the surface females did not prefer either males. Among the six cave populations studied, females of the eyed cave form and females of one of the five eyeless cave populations showed a preference for large males. Apparently, not all cave populations of Astyanax have evolved non-visual mating preferences. We discuss the role of selection by benefits of non-visual mate choice for the evolution of non-visual mating preferences
Polyvinylidene fluoride was dissolved together with solid sodium hydroxide as catalyst in a dimethylsulfoxide/ acetone mixture and moderately dehydrofluorinated. The dehydrofluorination leads to a partial degradation of the fluorohydrocarbons, and in particular to main-chain scission and to formation of carbon double or triple bonds. This enhances the absorption at UV-vis frequencies. The degradation process also generates a large amount of excess charges in the polymer, which influence the electrical polarization behavior of the dehydrofluorinated polymer. Uniaxial stretching of moderately dehydrofluorinated polyvinylidene fluoride leads to films in a polar phase. Dipole polarization in the degraded and stretched films is demonstrated by means of switching experiments
Phase compactons
(2006)
We study the phase dynamics of a chain of autonomous, self-sustained, dispersively coupled oscillators. In the quasicontinuum limit the basic discrete model reduces to a Korteveg-de Vries-like equation, but with a nonlinear dispersion. The system supports compactons - solitary waves with a compact support - and kovatons - compact formations of glued together kink-antikink pairs that propagate with a unique speed, but may assume an arbitrary width. We demonstrate that lattice solitary waves, though not exactly compact, have tails which decay at a superexponential rate. They are robust and collide nearly elastically and together with wave sources are the building blocks of the dynamics that emerges from typical initial conditions. In finite lattices, after a long time, the dynamics becomes chaotic. Numerical studies of the complex Ginzburg-Landau lattice show that the non-dispersive coupling causes a damping and deceleration, or growth and acceleration, of compactons. A simple perturbation method is applied to study these effects. (c) 2006 Elsevier B.V. All rights reserved
Filamin c is the predominantly expressed filamin isoform in striated muscles. It is localized in myofibrillar Z- discs, where it binds FATZ and myotilin, and in myotendinous junctions and intercalated discs. Here, we identify Xin, the protein encoded by the human gene 'cardiomyopathy associated 1' (CMYA1) as filamin c binding partner at these specialized structures where the ends of myofibrils are attached to the sarcolemma. Xin directly binds the EVH1 domain proteins Mena and VASP. In the adult heart, Xin and Mena/VASP colocalize with filamin c in intercalated discs. In cultured cardiomyocytes, the proteins also localize in the nonstriated part of myofibrils, where sarcomeres are assembled and an extensive reorganization of the actin cytoskeleton occurs. Unusual intraexonic splicing events result in the existence of three Xin isoforms that associate differentially with its ligands. The identification of the complex filamin c-Xin-Mena/VASP provides a first glance on the role of Xin in the molecular mechanisms involved in developmental and adaptive remodeling of the actin cytoskeleton during cardiac morphogenesis and sarcomere assembly. (c) 2006 Elsevier Inc. All rights reserved
[1] Spatial patterns of land surface and subsurface characteristics often exert significant control over hydrological processes at many scales. Recognition of the dominant controls at the watershed scale, which is a prerequisite to successful prediction of system responses, will require significant progress in many different research areas. The development and improvement of techniques for mapping structures and spatiotemporal patterns using geophysical and remote sensing techniques would greatly benefit watershed science but still requires a significant synthesis effort. Effective descriptions of hydrological systems will also significantly benefit from new scaling and averaging techniques, from new mathematical description for spatial pattern/structures and their dynamics, and also from an understanding and quantification of structure and pattern-building processes in different compartments ( soils, rocks, and land surface) and at different scales. The advances that are needed to tackle these complex challenges could be greatly facilitated through the development of an interdisciplinary research framework that explores instrumentation, theory, and simulation components and that is implemented in a coordinated manner