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Influenza virus vRNPs: quantitative investigations via fluorescence
cross-correlation spectroscopy
(2017)
Direct visualization of APLP1 cell-cell adhesion platforms via fluorescence fluctuation spectroscopy
(2017)
Tailed bacteriophages specific for Gram‐negative bacteria encounter lipopolysaccharide (LPS) during the first infection steps. Yet, it is not well understood how biochemistry of these initial interactions relates to subsequent events that orchestrate phage adsorption and tail rearrangements to initiate cell entry. For many phages, long O‐antigen chains found on the LPS of smooth bacterial strains serve as essential receptor recognized by their tailspike proteins (TSP). Many TSP are depolymerases and O‐antigen cleavage was described as necessary step for subsequent orientation towards a secondary receptor. However, O‐antigen specific host attachment must not always come along with O‐antigen degradation. In this issue of Molecular Microbiology Prokhorov et al. report that coliphage G7C carries a TSP that deacetylates O‐antigen but does not degrade it, whereas rough strains or strains lacking O‐antigen acetylation remain unaffected. Bacteriophage G7C specifically functionalizes its tail by attaching the deacetylase TSP directly to a second TSP that is nonfunctional on the host's O‐antigen. This challenges the view that bacteriophages use their TSP only to clear their way to a secondary receptor. Rather, O‐antigen specific phages may employ enzymatically active TSP as a tool for irreversible LPS membrane binding to initiate subsequent infection steps.
Kijko et al. (2016) present various methods to estimate parameters that are relevant for probabilistic seismic-hazard assessment. One of these parameters, although not the most influential, is the maximum possible earthquake magnitude m(max). I show that the proposed estimation of m(max) is based on an erroneous equation related to a misuse of the estimator in Cooke (1979) and leads to unstable results. So far, reported finite estimations of m(max) arise from data selection, because the estimator in Kijko et al. (2016) diverges with finite probability. This finding is independent of the assumed distribution of earthquake magnitudes. For the specific choice of the doubly truncated Gutenberg-Richter distribution, I illustrate the problems by deriving explicit equations. Finally, I conclude that point estimators are generally not a suitable approach to constrain m(max).
Editorial
(2017)