Refine
Year of publication
Document Type
- Article (170) (remove)
Language
- English (170) (remove)
Is part of the Bibliography
- yes (170) (remove)
Keywords
- football (5)
- exercise (4)
- kinetics (3)
- obesity (3)
- stunting (3)
- COVID-19 (2)
- Physical activity (2)
- SEPE (2)
- SNARC (2)
- Summer Schools (2)
- achilles tendinopathy (2)
- adolescents (2)
- attention (2)
- body height (2)
- climate change (2)
- diabetes (2)
- diffusion (2)
- electromyography (2)
- handgrip strength (2)
- health care (2)
- human physical conditioning (2)
- language acquisition (2)
- literature review (2)
- longitudinal (2)
- malnutrition (2)
- maturation (2)
- muscle strength (2)
- pre-school (2)
- resistance training (2)
- school mathematics (2)
- skills (2)
- virtual reality (2)
- wheat (2)
- youth sports (2)
- 3D thermal model (1)
- 5-methoxycarbonylmethyl-2-thiouridine (1)
- ACWR (1)
- AFLP (1)
- ALOS World 3D (1)
- APP (1)
- ASTER GDEM (1)
- Active noise control (1)
- Adipose tissue (1)
- Adolescents (1)
- Adult-child interaction (1)
- Advection and convection (1)
- Aftercare (1)
- Aging (1)
- Akan (1)
- Akt pathway (1)
- Animal personality (1)
- Arabica coffee (1)
- Arabidopsis thaliana (1)
- Bacteria (1)
- Barriers (1)
- Bayesian modelling (1)
- Biomarker (1)
- CDOM (1)
- COVID-19 pandemic (1)
- CRISPR editing validation (1)
- Cell-free protein synthesis (1)
- Central European Basin System (1)
- Chew Bahir (1)
- Chlamydomonas (1)
- Chronic conditions (1)
- Chronic low back pain (1)
- Cognitive fatigue (1)
- Convergence (1)
- Conversation Analysis (1)
- Copernicus DEM (1)
- Coping (1)
- Cross-frequency PLV (1)
- Cystic fibrosis (1)
- Cytochrome b (1)
- DEM noise (1)
- DXA (1)
- Damage assessment (1)
- Data pooling (1)
- Delphi study (1)
- Developmental hyperscanning (1)
- Digital Health (1)
- Digital intervention (1)
- Disturbance impacts (1)
- Disturbance indicator (1)
- Dual EEG analysis (1)
- Dynamometry (1)
- EEG (1)
- Eating behavior (1)
- Eccentric muscle action (1)
- Electronic Health (1)
- Electrophysiology (1)
- Elephant disturbance (1)
- Embodied cognition (1)
- Energy expenditure (1)
- European hare (1)
- Exertion (1)
- Feature selection (1)
- FieldTrip (1)
- Fluorescence (1)
- Fourier analysis (1)
- Fresh water fish (1)
- GPS (1)
- Gait (1)
- Gene expression (1)
- Genetics (1)
- Geothermal field (1)
- German-Jewish History (1)
- Germany (1)
- Glucose homeostasis (1)
- Grip force (1)
- GxLMS algorithm (1)
- H2S biosynthesis (1)
- HDL (1)
- HIV (1)
- Hamstring-quadriceps ratio (1)
- Health insurance (1)
- Heat transport by conduction (1)
- Hippo signaling (1)
- Human physical conditioning (1)
- ICDP (1)
- Individualized therapy (1)
- Injury (1)
- Injury risk (1)
- Insulin resistance (1)
- Inter-individual differences (1)
- Interactional Linguistics (1)
- Internet of Things (1)
- Interoception (1)
- Intuitive eating (1)
- Iron Age (1)
- Irradiation (1)
- Island biogeography (1)
- Jurkat cells (1)
- Just so stories (1)
- Juvenile idiopathic arthritis (1)
- K−12 teachers (1)
- LC-MS/MS (1)
- LC/HRMS (1)
- LCSM (1)
- LC–MS/MS (1)
- LDL (1)
- LMS without reference signal (1)
- Lake Holzmaar (1)
- Lake Malawi (1)
- Levy walks (1)
- Locally structured correlation (1)
- Locally structured standard deviation (1)
- M1/M2 differentiation (1)
- MALDI-TOF-MS (1)
- MCI (1)
- MSAP (1)
- Mandarin-English bilinguals (1)
- Martial arts (1)
- Matthew effect (1)
- Membrane proteins (1)
- Mental number line (1)
- Metabolic syndrome (1)
- MiSpEx (1)
- MiSpEx-network (1)
- Micro-translantation (1)
- Microtus arvalis (1)
- Mindfulness (1)
- Mitochondria (1)
- Mixed methods (1)
- Mobile Health (1)
- Mobile diagnostics (1)
- Moco biosynthesis (1)
- Monte Carlo method (1)
- Monte-Carlo simulation (1)
- Motor system (1)
- Movement (1)
- Movement ecology (1)
- Muscle strength (1)
- Musculoskeletal and neural physiological phenomena (1)
- N400 (1)
- NAFLD/MAFLD (1)
- Non-invasive vagus nerve stimulation (1)
- Noradrenaline (1)
- Number processing (1)
- NutriAct Family Study (1)
- Nutrition (1)
- ODBA (1)
- Obesity (1)
- Older adults (1)
- Omicron (1)
- Overhead athletes (1)
- PLV (1)
- Partial Little Square (1)
- Partnership (1)
- Phase Locking Value (1)
- Photodynamics (1)
- Phylogeny (1)
- Physical training (1)
- Pipistrellus nathusii (1)
- Plyometric exercise (1)
- Postural control (1)
- Prevention (1)
- Prior knowledge (1)
- Prospective (1)
- Protective factors (1)
- Protein expression (1)
- Quality of life (1)
- Quantitative Trait Locus (1)
- Quantitative Trait Locus analysis (1)
- Randomized controlled trial (1)
- Randomized-controlled trial (1)
- Rehabilitation (1)
- Repetition (1)
- Reproducible benchmarking (1)
- Resiliency (1)
- Resistance training (1)
- Rotifera (1)
- Rural health (1)
- SARS-CoV-2 (1)
- SEPE Factors (1)
- SEPS factors (1)
- SFON (1)
- SRT (1)
- SRTM (1)
- Sedimentary basin (1)
- Shire River (1)
- Shoulder (1)
- Social-Economic-Political-Emotional (SEPE) factors (1)
- South-Eastern Africa (1)
- Specific wood density (1)
- Sport-specific performance (1)
- St. Nicolas House Analysis (1)
- Standard deviation (1)
- Statistical Exercise (1)
- Stress response (1)
- Sway (1)
- TAVI (1)
- TLR signaling (1)
- TMAO reductase (1)
- TMS (1)
- TanDEM-X (1)
- Telehealth (1)
- Telemedicine (1)
- Tiredness (1)
- Tree allometry (1)
- Type 1 diabetes (1)
- Ulmener Maar Tephra (1)
- Union (1)
- VR (1)
- Variance (1)
- Wearable electronic device (1)
- Wearable technology (1)
- Wood specific gravity (1)
- Woody aboveground biomass (1)
- WorldDEM (1)
- X-ray (1)
- Yamal (1)
- Yap1/Wwtr1 (Taz) (1)
- accelerometer (1)
- acclimation (1)
- acid mine drainage (1)
- acoustic communication (1)
- acyclic diene metathesis (ADMET) polymerization (1)
- adaptive management (1)
- addition (1)
- adipose tissue (1)
- advanced dynamic flow (1)
- aerobic power (1)
- aged (1)
- aggression (1)
- aging (1)
- agricultural landscape (1)
- allocation policies (1)
- alpha-2 (1)
- amino acids (1)
- animal migration (1)
- animal personality (1)
- anomalous diffusion (1)
- anterior PNP (1)
- anterior cruciate ligament (1)
- anthropometry (1)
- anti-cancer drugs (1)
- antibody (1)
- antidepressants (1)
- apoptosis (1)
- approximate methods (1)
- arable weeds (1)
- asymptotic method (1)
- athletes (1)
- athletic performance (1)
- augmented reality (1)
- automated radio telemetry (1)
- balance (1)
- baroclinicity (1)
- basic need satisfaction and frustration (1)
- bats (1)
- behavior problems (1)
- behavioral and self-report measures (1)
- behavioral type (1)
- behaviour (1)
- bibliometric analysis (1)
- biodiversity conservation (1)
- biological age (1)
- biomechanics (1)
- birth weight (1)
- bis-MGD (1)
- blockchain (1)
- body mass index (1)
- body proportions (1)
- bound phenolic compounds (1)
- brain health (1)
- breastfeeding (1)
- buffer zones (1)
- burnout (1)
- business process management (1)
- business processes (1)
- cTBS (1)
- callous-unemotional traits (1)
- callousness (1)
- camelid antibody (1)
- camelid heavy-chain-only antibodies (1)
- capabilities (1)
- carbon cycling (1)
- cardiac catheterization (CC) (1)
- cardiac development (1)
- cardiology (1)
- cardiomyopathy (1)
- cardiovascular diseases (1)
- catch-up-growth (1)
- cellular bioenergetics (1)
- cellulose polymeric organic matter (1)
- central and peripheral vision (1)
- cereal leaf beetle (1)
- change of direction speed (1)
- changepoint analysis (1)
- changepoint detection (1)
- chaperone (1)
- child growth (1)
- children and adolescents (1)
- chimera (1)
- cholesterol (1)
- chronic health condition (1)
- chronic undernutrition (1)
- citation analysis (1)
- climate change adaptation (1)
- climate policy (1)
- clinical sample (1)
- coffee processing (1)
- cognitive bias (1)
- cognitive/muscular fatigue (1)
- color (1)
- community model (1)
- composition (1)
- constraint (1)
- consultation (1)
- content knowledge (1)
- continuing education activities (1)
- coping strategies (1)
- copy number analyses (1)
- corpus dataset (1)
- cost optimisation (1)
- counter-speech (1)
- counting (1)
- creativity (1)
- cross-national (1)
- cross-species capture (1)
- cyberaggression (1)
- cyberhate (1)
- cytosine methylation (1)
- cytosolic tRNA thiolation (1)
- daily home-made measurements (1)
- deep neural networks (1)
- deferred choice (1)
- dental eruption (1)
- depressive disorder (1)
- depressive symptoms (1)
- derivational complexity (1)
- design of experiment (1)
- design thinking (1)
- development (1)
- diabetes mellitus (1)
- diabetic (1)
- digital technologies (1)
- digital transformation (1)
- diketopiperazine (1)
- disaster risk reduction (1)
- discrepancy principle (1)
- disorder recognition (1)
- distress (1)
- drought events (1)
- drought intensity (1)
- drought projections (1)
- drug delivery (1)
- drug-sensitivity prediction (1)
- eavesdropping (1)
- eccentric-plyometric (1)
- echolocation (1)
- economy (1)
- ecophysiology (1)
- ecosystem restoration (1)
- education (1)
- eicosanoids (1)
- elderly (1)
- electrochemistry (1)
- elevated plus-maze (1)
- elf-determination theory (1)
- embodied cognition (1)
- emergency management (1)
- emotional regulation (1)
- emotional stress (1)
- endocardium (1)
- endophytes (1)
- energy expenditure (1)
- energy policy (1)
- enhancement (1)
- entropy (1)
- environmental pollution (1)
- erythropoiesis (1)
- europe (1)
- european (1)
- everyday life (1)
- exercise cognition (1)
- exercise test (1)
- exercise training (1)
- external load (1)
- extracellular enzymes (1)
- extremophiles (1)
- eye movements (1)
- fear (1)
- feature selection (1)
- federated learning (1)
- feeling of presence (1)
- fence ecology (1)
- fiction (1)
- finite-size effects (1)
- first-passage time (1)
- first-reaction time (1)
- fitness (1)
- flexibility (1)
- floods (1)
- food access (1)
- food web (1)
- formal semantics (1)
- fractionation (1)
- frailty tool (1)
- frame index (1)
- frames of reference (1)
- freshwater (1)
- frustration (1)
- functional performance (1)
- functional traits (1)
- fungal pathogens (1)
- fungi (1)
- gait (1)
- games (1)
- genome scan (1)
- global change (1)
- graphs (1)
- ground reaction forces (1)
- growth references (1)
- growth standards (1)
- growth tempo (1)
- guideline (1)
- happiness (1)
- hate speech (1)
- healthcare (1)
- heart rate (1)
- heavy-chain-only antibody (1)
- height in history (1)
- heliozoa (1)
- herbivory (1)
- high density lipoprotein cholesterol (1)
- high-intensity-interval training (1)
- high-sodium (1)
- hippocampal-prefrontal network (1)
- historical growth (1)
- home range (1)
- homologous recombination deficiency (1)
- homology-directed repair (1)
- hospitalization (1)
- human excised skin (1)
- hybridization capture (1)
- hydrolysis (1)
- iPhone (1)
- imaginary world (1)
- implicit learning (1)
- in-service training (1)
- injury risk (1)
- innovation laboratories (1)
- insulin (1)
- insulin resistance (1)
- integration (1)
- intellectual ability (1)
- intelligence (1)
- intergroup contacts (1)
- internal load (1)
- intonation units (1)
- intra-organ-communication (1)
- intraguild predation (1)
- ion-exchange chromatography (1)
- kelp (1)
- kinematics (1)
- knots (1)
- lake catchments (1)
- lakes (1)
- landscape transience (1)
- language courses (1)
- linear enamel hypoplasia (1)
- linear sprint (1)
- lipid peroxidation (1)
- lipids (1)
- locus coeruleus (1)
- long-term effects (1)
- low back pain (1)
- low density lipoprotein cholesterol (1)
- low-back-pain (1)
- machine learning (1)
- macrostructure (1)
- magnitude estimation (1)
- major depressive disorder (1)
- matched time (1)
- math (1)
- mathematical development (1)
- mathematical precursor (1)
- mcgraph (1)
- measurement (1)
- mechanobiology (1)
- mental health (1)
- mental imagery (1)
- mental number line (1)
- mental simulation (1)
- meta-science (1)
- metabolic disease (1)
- metathesis (1)
- meteorological drought (1)
- methods (1)
- miRNA (1)
- miRNAs (1)
- microfacies (1)
- microplastics (1)
- microstructure (1)
- migrants (1)
- migration (1)
- mild cognitive impairment (1)
- mindfulness-based stress reduction (1)
- mini growth spurt (1)
- mining lakes (1)
- mitochondrial adaptation (1)
- molecular species identification (1)
- molecular weaving (1)
- molybdenum cofactor (1)
- monensin (1)
- mortality (1)
- motor-control-exercise (1)
- movement (1)
- multidisciplinary intervention (1)
- multidisciplinary-therapy (1)
- multiple modalities (1)
- muscle growth (1)
- muscle metabolism (1)
- muscle tissue (1)
- musculoskeletal and neural physiological phenomena (1)
- museum specimens (1)
- myocardium (1)
- nanobodies (1)
- nanogels (1)
- narrative (1)
- narrative skills (1)
- natural particle (1)
- need profiles (1)
- neovascularization (1)
- network reconstruction (1)
- networks (1)
- neurological disorders (1)
- neuromuscular (1)
- neutralization (1)
- non-adjacent dependencies (1)
- nonlinear operator (1)
- novel biomarkers (1)
- nucleic acids (1)
- number knowledge (1)
- numerical development (1)
- numerical skills (1)
- nutrition (1)
- nutritional status (1)
- object search (1)
- older patients (1)
- oncology (1)
- open-field (1)
- optimal rate (1)
- oracles (1)
- oxidative stress (1)
- oxygen consumption (1)
- pace of life (1)
- paleoclimate (1)
- pandemic (1)
- parentage (1)
- past biosphere (1)
- peak height velocity (1)
- pedagogical content knowledge (PCK) (1)
- pedagogical reasoning (1)
- peptide biomarkers (1)
- performance (1)
- performance evaluation (1)
- periodic entanglement (1)
- permafrost (1)
- phonetics (1)
- phonotaxis (1)
- photoresponse (1)
- photosynthesis (1)
- physical fitness (1)
- physical time (1)
- physiology (1)
- playback (1)
- plyometric exercise (1)
- political ideology (1)
- polyenoic fatty acids (1)
- post-natal (1)
- posterior P600 (1)
- pre-natal (1)
- precaution (1)
- precuneus (1)
- predictability (1)
- predictive models (1)
- preschool children (1)
- preschoolers (1)
- prevention (1)
- priming (1)
- privacy and security (1)
- privacy attack (1)
- probabilistic processing (1)
- problem solving (1)
- professional development (1)
- prosocial (1)
- prosody (1)
- protein modification (1)
- psycho-oncology (1)
- psychoeducation (1)
- psychopathology (1)
- psychophysiological (1)
- psychotherapy process (1)
- pubertal timing (1)
- public health (1)
- pupil diameter (1)
- purification (1)
- quality (1)
- questioning solutions (1)
- random sampling (1)
- recombinant inbred line (1)
- redox state (1)
- refined consensus model (RCM) (1)
- refugees (1)
- regularization (1)
- regulation of growth (1)
- remote sensing data (1)
- remote teaching (1)
- renewable energy (1)
- repetition (1)
- reproductive success (1)
- research design (1)
- resource-tracking (1)
- response inhibition (1)
- response styles theory (1)
- response time (1)
- resting-state fMRI (1)
- return-to-sport (1)
- reversed-phase chromatography (1)
- review (1)
- rheumatic diseases (1)
- risk management (1)
- role-play (1)
- rotifer (1)
- rule learning (1)
- rumination (1)
- runners (1)
- running mechanics (1)
- rural (1)
- sAA (1)
- scene memorization (1)
- scene viewing (1)
- science teaching (1)
- secular changes (1)
- sedaDNA (1)
- sedentary (1)
- sediment core (1)
- selenite (1)
- self-control (1)
- sensitivity (1)
- serial reaction time (SRT) task (1)
- shared leadership (1)
- shell-like geometries (1)
- short-term growth (1)
- signal propagation (1)
- single case analysis (1)
- single domain antibodies (1)
- single-case design (1)
- single-case experimental design (1)
- skeletal age (1)
- skin penetration (1)
- smart contracts (1)
- social class (1)
- social environment (1)
- social network (1)
- social status insecurity (1)
- socioeconomy (1)
- solitary bees (1)
- soliton (1)
- sonography (1)
- source-to-sink (1)
- spatial autocorrelation (1)
- spatial frequencies (1)
- spatial language (1)
- spatial updating (1)
- spatially explicit (1)
- special education (1)
- speech (1)
- speed (1)
- sport-specific performance (1)
- sports (1)
- stability (1)
- standardized patient (1)
- standardized patient information (1)
- standards (1)
- standing long jump (1)
- starch granule (1)
- starch granule morphology (1)
- starch granule size (1)
- starch metabolism (1)
- step-growth polymerization (1)
- stochastic resetting (1)
- storm tracks (1)
- stratigraphy (1)
- stress (1)
- stress intervention (1)
- stress management (1)
- stretch shortening cycle exercise (1)
- striking combat sports (1)
- structural equation model (1)
- study designs (1)
- study protocol (1)
- subtraction (1)
- sulfite oxidase (1)
- sustainability (1)
- syntax (1)
- tVNS (1)
- tacrolimus formulation (1)
- taekwondo electronic scoring system (1)
- taekwondo-specific testing (1)
- talk-in-interaction (1)
- tangles (1)
- target capture (1)
- teacher learning (1)
- teacher quality (1)
- teaching practice (1)
- tendinosis (1)
- therapist competence (1)
- theta (1)
- time-efficient exercise (1)
- toxicity (1)
- training (1)
- training adaptation (1)
- transformation (1)
- transformation products (1)
- translation (1)
- treatment integrity (1)
- triglycerides (1)
- type 2 diabetes (1)
- type specimens (1)
- ultrasound (1)
- uncaring (1)
- unemotional (1)
- ungulate (1)
- usability (1)
- varves (1)
- veterinary cordon fence (1)
- veterinary drugs (1)
- vicious cycle (1)
- virus infection (1)
- voice (1)
- water sports (1)
- web-based (1)
- weight loss (1)
- wh-ex-situ (1)
- wh-in-situ (1)
- wh-questions (1)
- wildlife and habitat management (1)
- workflow patterns (1)
- working memory (1)
- yellow flags (1)
- youth soccer (1)
- youth sport (1)
- zebrafish (1)
- α-amylase/trypsin inhibitors (1)
- social network analysis (1)
- team creativity (1)
- intrapreneurship (1)
Institute
- Extern (170) (remove)
Simultaneous Barcode Sequencing of Diverse Museum Collection Specimens Using a Mixed RNA Bait Set
(2022)
A growing number of publications presenting results from sequencing natural history collection specimens reflect the importance of DNA sequence information from such samples. Ancient DNA extraction and library preparation methods in combination with target gene capture are a way of unlocking archival DNA, including from formalin-fixed wet-collection material. Here we report on an experiment, in which we used an RNA bait set containing baits from a wide taxonomic range of species for DNA hybridisation capture of nuclear and mitochondrial targets for analysing natural history collection specimens. The bait set used consists of 2,492 mitochondrial and 530 nuclear RNA baits and comprises specific barcode loci of diverse animal groups including both invertebrates and vertebrates. The baits allowed to capture DNA sequence information of target barcode loci from 84% of the 37 samples tested, with nuclear markers being captured more frequently and consensus sequences of these being more complete compared to mitochondrial markers. Samples from dry material had a higher rate of success than wet-collection specimens, although target sequence information could be captured from 50% of formalin-fixed samples. Our study illustrates how efforts to obtain barcode sequence information from natural history collection specimens may be combined and are a way of implementing barcoding inventories of scientific collection material.
The purpose of this study was to examine the test-retest reliability, and convergent and discriminative validity of a new taekwondo-specific change-of-direction (COD) speed test with striking techniques (TST) in elite taekwondo athletes. Twenty (10 males and 10 females) elite (athletes who compete at national level) and top-elite (athletes who compete at national and international level) taekwondo athletes with an average training background of 8.9 ± 1.3 years of systematic taekwondo training participated in this study. During the two-week test-retest period, various generic performance tests measuring COD speed, balance, speed, and jump performance were carried out during the first week and as a retest during the second week. Three TST trials were conducted with each athlete and the best trial was used for further analyses. The relevant performance measure derived from the TST was the time with striking penalty (TST-TSP). TST-TSP performances amounted to 10.57 ± 1.08 s for males and 11.74 ± 1.34 s for females. The reliability analysis of the TST performance was conducted after logarithmic transformation, in order to address the problem of heteroscedasticity. In both groups, the TST demonstrated a high relative test-retest reliability (intraclass correlation coefficients and 90% compatibility limits were 0.80 and 0.47 to 0.93, respectively). For absolute reliability, the TST’s typical error of measurement (TEM), 90% compatibility limits, and magnitudes were 4.6%, 3.4 to 7.7, for males, and 5.4%, 3.9 to 9.0, for females. The homogeneous sample of taekwondo athletes meant that the TST’s TEM exceeded the usual smallest important change (SIC) with 0.2 effect size in the two groups. The new test showed mostly very large correlations with linear sprint speed (r = 0.71 to 0.85) and dynamic balance (r = −0.71 and −0.74), large correlations with COD speed (r = 0.57 to 0.60) and vertical jump performance (r = −0.50 to −0.65), and moderate correlations with horizontal jump performance (r = −0.34 to −0.45) and static balance (r = −0.39 to −0.44). Top-elite athletes showed better TST performances than elite counterparts. Receiver operating characteristic analysis indicated that the TST effectively discriminated between top-elite and elite taekwondo athletes. In conclusion, the TST is a valid, and sensitive test to evaluate the COD speed with taekwondo specific skills, and reliable when considering ICC and TEM. Although the usefulness of the TST is questioned to detect small performance changes in the present population, the TST can detect moderate changes in taekwondo-specific COD speed.
Objective: To examine the effect of plyometric jump training on skeletal muscle hypertrophy in healthy individuals.
Methods: A systematic literature search was conducted in the databases PubMed, SPORTDiscus, Web of Science, and Cochrane Library up to September 2021.
Results: Fifteen studies met the inclusion criteria. The main overall finding (44 effect sizes across 15 clusters median = 2, range = 1–15 effects per cluster) indicated that plyometric jump training had small to moderate effects [standardised mean difference (SMD) = 0.47 (95% CIs = 0.23–0.71); p < 0.001] on skeletal muscle hypertrophy. Subgroup analyses for training experience revealed trivial to large effects in non-athletes [SMD = 0.55 (95% CIs = 0.18–0.93); p = 0.007] and trivial to moderate effects in athletes [SMD = 0.33 (95% CIs = 0.16–0.51); p = 0.001]. Regarding muscle groups, results showed moderate effects for the knee extensors [SMD = 0.72 (95% CIs = 0.66–0.78), p < 0.001] and equivocal effects for the plantar flexors [SMD = 0.65 (95% CIs = −0.25–1.55); p = 0.143]. As to the assessment methods of skeletal muscle hypertrophy, findings indicated trivial to small effects for prediction equations [SMD = 0.29 (95% CIs = 0.16–0.42); p < 0.001] and moderate-to-large effects for ultrasound imaging [SMD = 0.74 (95% CIs = 0.59–0.89); p < 0.001]. Meta-regression analysis indicated that the weekly session frequency moderates the effect of plyometric jump training on skeletal muscle hypertrophy, with a higher weekly session frequency inducing larger hypertrophic gains [β = 0.3233 (95% CIs = 0.2041–0.4425); p < 0.001]. We found no clear evidence that age, sex, total training period, single session duration, or the number of jumps per week moderate the effect of plyometric jump training on skeletal muscle hypertrophy [β = −0.0133 to 0.0433 (95% CIs = −0.0387 to 0.1215); p = 0.101–0.751].
Conclusion: Plyometric jump training can induce skeletal muscle hypertrophy, regardless of age and sex. There is evidence for relatively larger effects in non-athletes compared with athletes. Further, the weekly session frequency seems to moderate the effect of plyometric jump training on skeletal muscle hypertrophy, whereby more frequent weekly plyometric jump training sessions elicit larger hypertrophic adaptations.
Frailty assessment is recommended before elective transcatheter aortic valve implantation (TAVI) to determine post-interventional prognosis. Several studies have investigated frailty in TAVI-patients using numerous assessments; however, it remains unclear which is the most appropriate tool for clinical practice. Therefore, we evaluate which frailty assessment is mainly used and meaningful for ≤30-day and ≥1-year prognosis in TAVI patients. Randomized controlled or observational studies (prospective/retrospective) investigating all-cause mortality in older (≥70 years) TAVI patients were identified (PubMed; May 2020). In total, 79 studies investigating frailty with 49 different assessments were included. As single markers of frailty, mostly gait speed (23 studies) and serum albumin (16 studies) were used. Higher risk of 1-year mortality was predicted by slower gait speed (highest Hazard Ratios (HR): 14.71; 95% confidence interval (CI) 6.50–33.30) and lower serum albumin level (highest HR: 3.12; 95% CI 1.80–5.42). Composite indices (five items; seven studies) were associated with 30-day (highest Odds Ratio (OR): 15.30; 95% CI 2.71–86.10) and 1-year mortality (highest OR: 2.75; 95% CI 1.55–4.87). In conclusion, single markers of frailty, in particular gait speed, were widely used to predict 1-year mortality. Composite indices were appropriate, as well as a comprehensive assessment of frailty. View Full-Text
“Chunking” spoken language
(2021)
In this introductory paper to the special issue on “Weak cesuras in talk-in-interaction”, we aim to guide the reader into current work on the “chunking” of naturally occurring talk. It is conducted in the methodological frameworks of Conversation Analysis and Interactional Linguistics – two approaches that consider the interactional aspect of humans talking with each other to be a crucial starting point for its analysis. In doing so, we will (1) lay out the background of this special issue (what is problematic about “chunking” talk-in-interaction, the characteristics of the methodological approach chosen by the contributors, the cesura model), (2) highlight what can be gained from such a revised understanding of “chunking” in talk-in-interaction by referring to previous work with this model as well as the findings of the contributions to this special issue, and (3) indicate further directions such work could take starting from papers in this special issue. We hope to induce a fruitful exchange on the phenomena discussed, across methodological divides.
Background: As the number of cardiac diseases continuously increases within the last years in modern society, so does cardiac treatment, especially cardiac catheterization. The procedure of a cardiac catheterization is challenging for both patients and practitioners. Several potential stressors of psychological or physical nature can occur during the procedure. The objective of the study is to develop and implement a stress management intervention for both practitioners and patients that aims to reduce the psychological and physical strain of a cardiac catheterization.
Methods: The clinical study (DRKS00026624) includes two randomized controlled intervention trials with parallel groups, for patients with elective cardiac catheterization and practitioners at the catheterization lab, in two clinic sites of the Ernst-von-Bergmann clinic network in Brandenburg, Germany. Both groups received different interventions for stress management. The intervention for patients comprises a psychoeducational video with different stress management technics and additional a standardized medical information about the cardiac catheterization examination. The control condition includes the in hospitals practiced medical patient education before the examination (usual care). Primary and secondary outcomes are measured by physiological parameters and validated questionnaires, the day before (M1) and after (M2) the cardiac catheterization and at a postal follow-up 6 months later (M3). It is expected that people with standardized information and psychoeducation show reduced complications during cardiac catheterization procedures, better pre- and post-operative wellbeing, regeneration, mood and lower stress levels over time. The intervention for practitioners includes a Mindfulness-based stress reduction program (MBSR) over 8 weeks supervised by an experienced MBSR practitioner directly at the clinic site and an operative guideline. It is expected that practitioners with intervention show improved perceived and chronic stress, occupational health, physical and mental function, higher effort-reward balance, regeneration and quality of life. Primary and secondary outcomes are measured by physiological parameters (heart rate variability, saliva cortisol) and validated questionnaires and will be assessed before (M1) and after (M2) the MBSR intervention and at a postal follow-up 6 months later (M3). Physiological biomarkers in practitioners will be assessed before (M1) and after intervention (M2) on two work days and a two days off. Intervention effects in both groups (practitioners and patients) will be evaluated separately using multivariate variance analysis.
Discussion: This study evaluates the effectiveness of two stress management intervention programs for patients and practitioners within cardiac catheter laboratory. Study will disclose strains during a cardiac catheterization affecting both patients and practitioners. For practitioners it may contribute to improved working conditions and occupational safety, preservation of earning capacity, avoidance of participation restrictions and loss of performance. In both groups less anxiety, stress and complications before and during the procedures can be expected. The study may add knowledge how to eliminate stressful exposures and to contribute to more (psychological) security, less output losses and exhaustion during work. The evolved stress management guidelines, training manuals and the standardized patient education should be transferred into clinical routines
Background: Biological age markers are a crucial indicator whether children are decelerated in growth tempo. Skeletal maturation is the standard measure. Yet, it relies on exposing children to x-radiation. Dental eruption is a potential, but highly debated, radiation free alternative.
Objectives: We assess the interrelationship between dental eruption and other maturational markers. We hypothesize that dental age correlates with body height and skeletal age. We further evaluate how the three different variables behave in cohorts from differing social backgrounds.
Sample and Method: Dental, skeletal and height data from the 1970s to 1990s from Guatemalan boys were converted into standard deviation scores, using external references for each measurement. The boys, aged between 7 and 12, derived from different social backgrounds (middle SES (N = 6529), low-middle SES (N = 736), low SES Ladino (N = 3653) and low SES Maya (N = 4587).
Results: Dental age shows only a weak correlation with skeletal age (0.18) and height (0.2). The distinction between cohorts differs according to each of the three measurements. All cohorts differ significantly in height. In skeletal maturation, the middle SES cohort is significantly advanced compared to all other cohorts. The periodically malnourished cohorts of low SES Mayas and Ladinos are significantly delayed in dental maturation compared to the well-nourished low-middle and middle class Ladino children.
Conclusion: Dental development is an independent system, that is regulated by different mechanisms than skeletal development and growth. Tooth eruption is sensitive to nutritional status, whereas skeletal age is more sensitive to socioeconomic background.
Strong as a Hippo’s Heart: Biomechanical Hippo Signaling During Zebrafish Cardiac Development
(2021)
The heart is comprised of multiple tissues that contribute to its physiological functions. During development, the growth of myocardium and endocardium is coupled and morphogenetic processes within these separate tissue layers are integrated. Here, we discuss the roles of mechanosensitive Hippo signaling in growth and morphogenesis of the zebrafish heart. Hippo signaling is involved in defining numbers of cardiac progenitor cells derived from the secondary heart field, in restricting the growth of the epicardium, and in guiding trabeculation and outflow tract formation. Recent work also shows that myocardial chamber dimensions serve as a blueprint for Hippo signaling-dependent growth of the endocardium. Evidently, Hippo pathway components act at the crossroads of various signaling pathways involved in embryonic zebrafish heart development. Elucidating how biomechanical Hippo signaling guides heart morphogenesis has direct implications for our understanding of cardiac physiology and pathophysiology.
The prevalence of obesity in the pediatric population has become a major public health issue. Indeed, the dramatic increase of this epidemic causes multiple and harmful consequences, Physical activity, particularly physical exercise, remains to be the cornerstone of interventions against childhood obesity. Given the conflicting findings with reference to the relevant literature addressing the effects of exercise on adiposity and physical fitness outcomes in obese children and adolescents, the effect of duration-matched concurrent training (CT) [50% resistance (RT) and 50% high-intensity-interval-training (HIIT)] on body composition and physical fitness in obese youth remains to be elucidated. Thus, the purpose of this study was to examine the effects of 9-weeks of CT compared to RT or HIIT alone, on body composition and selected physical fitness components in healthy sedentary obese youth. Out of 73 participants, only 37; [14 males and 23 females; age 13.4 ± 0.9 years; body-mass-index (BMI): 31.2 ± 4.8 kg·m-2] were eligible and randomized into three groups: HIIT (n = 12): 3-4 sets×12 runs at 80–110% peak velocity, with 10-s passive recovery between bouts; RT (n = 12): 6 exercises; 3–4 sets × 10 repetition maximum (RM) and CT (n = 13): 50% serial completion of RT and HIIT. CT promoted significant greater gains compared to HIIT and RT on body composition (p < 0.01, d = large), 6-min-walking test distance (6 MWT-distance) and on 6 MWT-VO2max (p < 0.03, d = large). In addition, CT showed substantially greater improvements than HIIT in the medicine ball throw test (20.2 vs. 13.6%, p < 0.04, d = large). On the other hand, RT exhibited significantly greater gains in relative hand grip strength (p < 0.03, d = large) and CMJ (p < 0.01, d = large) than HIIT and CT. CT promoted greater benefits for fat, body mass loss and cardiorespiratory fitness than HIIT or RT modalities. This study provides important information for practitioners and therapists on the application of effective exercise regimes with obese youth to induce significant and beneficial body composition changes. The applied CT program and the respective programming parameters in terms of exercise intensity and volume can be used by practitioners as an effective exercise treatment to fight the pandemic overweight and obesity in youth.
Cognitive resources contribute to balance control. There is evidence that mental fatigue reduces cognitive resources and impairs balance performance, particularly in older adults and when balance tasks are complex, for example when trying to walk or stand while concurrently performing a secondary cognitive task.
We conducted a systematic literature search in PubMed (MEDLINE), Web of Science and Google Scholar to identify eligible studies and performed a random effects meta-analysis to quantify the effects of experimentally induced mental fatigue on balance performance in healthy adults. Subgroup analyses were computed for age (healthy young vs. healthy older adults) and balance task complexity (balance tasks with high complexity vs. balance tasks with low complexity) to examine the moderating effects of these factors on fatigue-mediated balance performance.
We identified 7 eligible studies with 9 study groups and 206 participants. Analysis revealed that performing a prolonged cognitive task had a small but significant effect (SMDwm = −0.38) on subsequent balance performance in healthy young and older adults. However, age- and task-related differences in balance responses to fatigue could not be confirmed statistically.
Overall, aggregation of the available literature indicates that mental fatigue generally reduces balance in healthy adults. However, interactions between cognitive resource reduction, aging and balance task complexity remain elusive.
Background: The COVID-19 pandemic has highlighted the importance of scientific endeavors. The goal of this systematic review is to evaluate the quality of the research on physical activity (PA) behavior change and its potential to contribute to policy-making processes in the early days of COVID-19 related restrictions.
Methods: We conducted a systematic review of methodological quality of current research according to PRISMA guidelines using Pubmed and Web of Science, of articles on PA behavior change that were published within 365 days after COVID-19 was declared a pandemic by the World Health Organization (WHO). Items from the JBI checklist and the AXIS tool were used for additional risk of bias assessment. Evidence mapping is used for better visualization of the main results. Conclusions about the significance of published articles are based on hypotheses on PA behavior change in the light of the COVID-19 pandemic.
Results: Among the 1,903 identified articles, there were 36% opinion pieces, 53% empirical studies, and 9% reviews. Of the 332 studies included in the systematic review, 213 used self-report measures to recollect prepandemic behavior in often small convenience samples. Most focused changes in PA volume, whereas changes in PA types were rarely measured. The majority had methodological reporting flaws. Few had very large samples with objective measures using repeated measure design (pre and during the pandemic). In addition to the expected decline in PA duration, these studies show that many of those who were active prepandemic, continued to be active during the pandemic.
Conclusions: Research responded quickly at the onset of the pandemic. However, most of the studies lacked robust methodology, and PA behavior change data lacked the accuracy needed to guide policy makers. To improve the field, we propose the implementation of longitudinal cohort studies by larger organizations such as WHO to ease access to data on PA behavior, and suggest those institutions set clear standards for this research. Researchers need to ensure a better fit between the measurement method and the construct being measured, and use both objective and subjective measures where appropriate to complement each other and provide a comprehensive picture of PA behavior.
Organisms often employ ecophysiological strategies to exploit environmental conditions and ensure bio-energetic success. However, the many complexities involved in the differential expression and flexibility of these strategies are rarely fully understood. Therefore, for the first time, using a three-part cross-disciplinary laboratory experimental analysis, we investigated the diversity and plasticity of photoresponsive traits employed by one family of environmentally contrasting, ecologically important phytoflagellates. The results demonstrated an extensive inter-species phenotypic diversity of behavioural, physiological, and compositional photoresponse across the Chlamydomonadaceae, and a multifaceted intra-species phenotypic plasticity, involving a broad range of beneficial photoacclimation strategies, often attributable to environmental predisposition and phylogenetic differentiation. Deceptively diverse and sophisticated strong (population and individual cell) behavioural photoresponses were observed, with divergence from a general preference for low light (and flexibility) dictated by intra-familial differences in typical habitat (salinity and trophy) and phylogeny. Notably, contrasting lower, narrow, and flexible compared with higher, broad, and stable preferences were observed in freshwater vs. brackish and marine species. Complex diversity and plasticity in physiological and compositional photoresponses were also discovered. Metabolic characteristics (such as growth rates, respiratory costs and photosynthetic capacity, efficiency, compensation and saturation points) varied elaborately with species, typical habitat (often varying more in eutrophic species, such as Chlamydomonas reinhardtii), and culture irradiance (adjusting to optimise energy acquisition and suggesting some propensity for low light). Considerable variations in intracellular pigment and biochemical composition were also recorded. Photosynthetic and accessory pigments (such as chlorophyll a, xanthophyll-cycle components, chlorophyll a:b and chlorophyll a:carotenoid ratios, fatty acid content and saturation ratios) varied with phylogeny and typical habitat (to attune photosystem ratios in different trophic conditions and to optimise shade adaptation, photoprotection, and thylakoid architecture, particularly in freshwater environments), and changed with irradiance (as reaction and harvesting centres adjusted to modulate absorption and quantum yield). The complex, concomitant nature of the results also advocated an integrative approach in future investigations. Overall, these nuanced, diverse, and flexible photoresponsive traits will greatly contribute to the functional ecology of these organisms, addressing environmental heterogeneity and potentially shaping individual fitness, spatial and temporal distribution, prevalence, and ecosystem dynamics.
The discovery that certain diseases have specific miRNA signatures which correspond to disease progression opens a new biomarker category. The detection of these small non-coding RNAs is performed routinely using body fluids or tissues with real-time PCR, next-generation sequencing, or amplification-based miRNA assays. Antibody-based detection systems allow an easy onset handling compared to PCR or sequencing and can be considered as alternative methods to support miRNA diagnostic in the future. In this study, we describe the generation of a camelid heavy-chain-only antibody specifically recognizing miRNAs to establish an antibody-based detection method. The generation of nucleic acid-specific binders is a challenge. We selected camelid binders via phage display, expressed them as VHH as well as full-length antibodies, and characterized the binding to several miRNAs from a signature specific for dilated cardiomyopathy. The described workflow can be used to create miRNA-specific binders and establish antibody-based detection methods to provide an additional way to analyze disease-specific miRNA signatures.
High-salt (HS) diets have recently been linked to oxidative stress in the brain, a fact that may be a precursor to behavioral changes, such as those involving anxiety-like behavior. However, to the best of our knowledge, no study has evaluated the amygdala redox status after consuming a HS diet in the pre- or postweaning periods. This study aimed to evaluate the amygdala redox status and anxiety-like behaviors in adulthood, after inclusion of HS diet in two periods: preconception, gestation, and lactation (preweaning); and only after weaning (postweaning). Initially, 18 females and 9 male Wistar rats received a standard (n = 9 females and 4 males) or a HS diet (n = 9 females and 5 males) for 120 days. After mating, females continued to receive the aforementioned diets during gestation and lactation. Weaning occurred at 21-day-old Wistar rats and the male offspring were subdivided: control-control (C-C)—offspring of standard diet fed dams who received a standard diet after weaning (n = 9–11), control-HS (C-HS)—offspring of standard diet fed dams who received a HS diet after weaning (n = 9–11), HS-C—offspring of HS diet fed dams who received a standard diet after weaning (n = 9–11), and HS-HS—offspring of HS diet fed dams who received a HS diet after weaning (n = 9–11). At adulthood, the male offspring performed the elevated plus maze and open field tests. At 152-day-old Wistar rats, the offspring were euthanized and the amygdala was removed for redox state analysis. The HS-HS group showed higher locomotion and rearing frequency in the open field test. These results indicate that this group developed hyperactivity. The C-HS group had a higher ratio of entries and time spent in the open arms of the elevated plus maze test in addition to a higher head-dipping frequency. These results suggest less anxiety-like behaviors. In the analysis of the redox state, less activity of antioxidant enzymes and higher levels of the thiobarbituric acid reactive substances (TBARS) in the amygdala were shown in the amygdala of animals that received a high-salt diet regardless of the period (pre- or postweaning). In conclusion, the high-salt diet promoted hyperactivity when administered in the pre- and postweaning periods. In animals that received only in the postweaning period, the addition of salt induced a reduction in anxiety-like behaviors. Also, regardless of the period, salt provided amygdala oxidative stress, which may be linked to the observed behaviors.
Importance Alcohol consumption (AC) leads to death and disability worldwide. Ongoing discussions on potential negative effects of the COVID-19 pandemic on AC need to be informed by real-world evidence.
Objective To examine whether lockdown measures are associated with AC and consumption-related temporal and psychological within-person mechanisms.
Design, Setting, and Participants This quantitative, intensive, longitudinal cohort study recruited 1743 participants from 3 sites from February 20, 2020, to February 28, 2021. Data were provided before and within the second lockdown of the COVID-19 pandemic in Germany: before lockdown (October 2 to November 1, 2020); light lockdown (November 2 to December 15, 2020); and hard lockdown (December 16, 2020, to February 28, 2021).
Main Outcomes and Measures Daily ratings of AC (main outcome) captured during 3 lockdown phases (main variable) and temporal (weekends and holidays) and psychological (social isolation and drinking intention) correlates.
Results Of the 1743 screened participants, 189 (119 [63.0%] male; median [IQR] age, 37 [27.5-52.0] years) with at least 2 alcohol use disorder (AUD) criteria according to the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) yet without the need for medically supervised alcohol withdrawal were included. These individuals provided 14 694 smartphone ratings from October 2020 through February 2021. Multilevel modeling revealed significantly higher AC (grams of alcohol per day) on weekend days vs weekdays (β = 11.39; 95% CI, 10.00-12.77; P < .001). Alcohol consumption was above the overall average on Christmas (β = 26.82; 95% CI, 21.87-31.77; P < .001) and New Year’s Eve (β = 66.88; 95% CI, 59.22-74.54; P < .001). During the hard lockdown, perceived social isolation was significantly higher (β = 0.12; 95% CI, 0.06-0.15; P < .001), but AC was significantly lower (β = −5.45; 95% CI, −8.00 to −2.90; P = .001). Independent of lockdown, intention to drink less alcohol was associated with lower AC (β = −11.10; 95% CI, −13.63 to −8.58; P < .001). Notably, differences in AC between weekend and weekdays decreased both during the hard lockdown (β = −6.14; 95% CI, −9.96 to −2.31; P = .002) and in participants with severe AUD (β = −6.26; 95% CI, −10.18 to −2.34; P = .002).
Conclusions and Relevance This 5-month cohort study found no immediate negative associations of lockdown measures with overall AC. Rather, weekend-weekday and holiday AC patterns exceeded lockdown effects. Differences in AC between weekend days and weekdays evinced that weekend drinking cycles decreased as a function of AUD severity and lockdown measures, indicating a potential mechanism of losing and regaining control. This finding suggests that temporal patterns and drinking intention constitute promising targets for prevention and intervention, even in high-risk individuals.
Objective: A role for microRNAs is implicated in several biological and pathological processes. We investigated the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on molecular markers of diabetic cardiomyopathy in rats.
Methods: Eighteen male Wistar rats (260 ± 10 g; aged 8 weeks) with streptozotocin (STZ)-induced type 1 diabetes mellitus (55 mg/kg, IP) were randomly allocated to three groups: control, MICT, and HIIT. The two different training protocols were performed 5 days each week for 5 weeks. Cardiac performance (end-systolic and end-diastolic dimensions, ejection fraction), the expression of miR-206, HSP60, and markers of apoptosis (cleaved PARP and cytochrome C) were determined at the end of the exercise interventions.
Results: Both exercise interventions (HIIT and MICT) decreased blood glucose levels and improved cardiac performance, with greater changes in the HIIT group (p < 0.001, η2: 0.909). While the expressions of miR-206 and apoptotic markers decreased in both training protocols (p < 0.001, η2: 0.967), HIIT caused greater reductions in apoptotic markers and produced a 20% greater reduction in miR-206 compared with the MICT protocol (p < 0.001). Furthermore, both training protocols enhanced the expression of HSP60 (p < 0.001, η2: 0.976), with a nearly 50% greater increase in the HIIT group compared with MICT.
Conclusions: Our results indicate that both exercise protocols, HIIT and MICT, have the potential to reduce diabetic cardiomyopathy by modifying the expression of miR-206 and its downstream targets of apoptosis. It seems however that HIIT is even more effective than MICT to modulate these molecular markers.
Aims: High intensity interval training (HIIT) improves mitochondrial characteristics. This study compared the impact of two workload-matched high intensity interval training (HIIT) protocols with different work:recovery ratios on regulatory factors related to mitochondrial biogenesis in the soleus muscle of diabetic rats.
Materials and methods: Twenty-four Wistar rats were randomly divided into four equal-sized groups: non-diabetic control, diabetic control (DC), diabetic with long recovery exercise [4–5 × 2-min running at 80%–90% of the maximum speed reached with 2-min of recovery at 40% of the maximum speed reached (DHIIT1:1)], and diabetic with short recovery exercise (5–6 × 2-min running at 80%–90% of the maximum speed reached with 1-min of recovery at 30% of the maximum speed reached [DHIIT2:1]). Both HIIT protocols were completed five times/week for 4 weeks while maintaining equal running distances in each session.
Results: Gene and protein expressions of PGC-1α, p53, and citrate synthase of the muscles increased significantly following DHIIT1:1 and DHIIT2:1 compared to DC (p ˂ 0.05). Most parameters, except for PGC-1α protein (p = 0.597), were significantly higher in DHIIT2:1 than in DHIIT1:1 (p ˂ 0.05). Both DHIIT groups showed significant increases in maximum speed with larger increases in DHIIT2:1 compared with DHIIT1:1.
Conclusion: Our findings indicate that both HIIT protocols can potently up-regulate gene and protein expression of PGC-1α, p53, and CS. However, DHIIT2:1 has superior effects compared with DHIIT1:1 in improving mitochondrial adaptive responses in diabetic rats.
The Role of the Precuneus in Human Spatial Updating in a Real Environment Setting—A cTBS Study
(2022)
As we move through an environment, we update positions of our body relative to other objects, even when some objects temporarily or permanently leave our field of view—this ability is termed egocentric spatial updating and plays an important role in everyday life. Still, our knowledge about its representation in the brain is still scarce, with previous studies using virtual movements in virtual environments or patients with brain lesions suggesting that the precuneus might play an important role. However, whether this assumption is also true when healthy humans move in real environments where full body-based cues are available in addition to the visual cues typically used in many VR studies is unclear. Therefore, in this study we investigated the role of the precuneus in egocentric spatial updating in a real environment setting in 20 healthy young participants who underwent two conditions in a cross-over design: (a) stimulation, achieved through applying continuous theta-burst stimulation (cTBS) to inhibit the precuneus and (b) sham condition (activated coil turned upside down). In both conditions, participants had to walk back with blindfolded eyes to objects they had previously memorized while walking with open eyes. Simplified trials (without spatial updating) were used as control condition, to make sure the participants were not affected by factors such as walking blindfolded, vestibular or working memory deficits. A significant interaction was found, with participants performing better in the sham condition compared to real stimulation, showing smaller errors both in distance and angle. The results of our study reveal evidence of an important role of the precuneus in a real-environment egocentric spatial updating; studies on larger samples are necessary to confirm and further investigate this finding.
Recent research suggests that design thinking practices may foster the development of needed capabilities in new digitalised landscapes. However, existing publications represent individual contributions, and we lack a holistic understanding of the value of design thinking in a digital world. No review, to date, has offered a holistic retrospection of this research. In response, in this bibliometric review, we aim to shed light on the intellectual structure of multidisciplinary design thinking literature related to capabilities relevant to the digital world in higher education and business settings, highlight current trends and suggest further studies to advance theoretical and empirical underpinnings. Our study addresses this aim using bibliometric methods—bibliographic coupling and co-word analysis as they are particularly suitable for identifying current trends and future research priorities at the forefront of the research. Overall, bibliometric analyses of the publications dealing with the related topics published in the last 10 years (extracted from the Web of Science database) expose six trends and two possible future research developments highlighting the expanding scope of the design thinking scientific field related to capabilities required for the (more sustainable and human-centric) digital world. Relatedly, design thinking becomes a relevant approach to be included in higher education curricula and human resources training to prepare students and workers for the changing work demands. This paper is well-suited for education and business practitioners seeking to embed design thinking capabilities in their curricula and for design thinking and other scholars wanting to understand the field and possible directions for future research.