Refine
Year of publication
- 2020 (42) (remove)
Document Type
- Other (42) (remove)
Keywords
- University of Potsdam (3)
- Universität Potsdam (3)
- Forschungsdaten (2)
- Research Data (2)
- Soft Law (2)
- Antifeminismus (1)
- COVID-19 (1)
- Climate-change impacts (1)
- Energy economics (1)
- Forschungsdatenmanagement (1)
Institute
- Department Sport- und Gesundheitswissenschaften (6)
- Fachgruppe Soziologie (4)
- Institut für Biochemie und Biologie (4)
- Bürgerliches Recht (3)
- Historisches Institut (3)
- Fachgruppe Politik- & Verwaltungswissenschaft (2)
- Institut für Chemie (2)
- Institut für Geowissenschaften (2)
- Institut für Germanistik (2)
- Kommissionen des Senats (2)
Der Potsdam Grievance Statistics File (PGSF) ist eine historische Datensammlung von Beschwerden, sog. Eingaben, die in der DDR von deren Bürgern eingereicht wurden. Die Eingaben wurden schriftlich oder mündlich gestellt und waren an staatliche Institutionen gerichtet. Der Staat zählte diese Eingaben und kategorisierte sie in Eingabenstatistiken.
Der PGSF enthält Eingabenstatistiken des Zeitraums 1970–1989 einer Wahrscheinlichkeitsstichprobe von im Jahr 1990 existierenden Kreisen. Zusätzlich finden sich Eingabenstatistiken eines Convenience-Samples von Kreisen aus dem Zeitraum 1970–1989.
Der Potsdam Grievance Statistics File (PGSF) ist eine historische Datensammlung von Beschwerden, sog. Eingaben, die in der DDR von deren Bürgern eingereicht wurden. Die Eingaben wurden schriftlich oder mündlich gestellt und waren an staatliche Institutionen gerichtet. Der Staat zählte diese Eingaben und kategorisierte sie in Eingabenstatistiken.
Der PGSF enthält Eingabenstatistiken des Zeitraums 1970–1989 einer Wahrscheinlichkeitsstichprobe von im Jahr 1990 existierenden Kreisen. Zusätzlich finden sich Eingabenstatistiken eines Convenience-Samples von Kreisen aus dem Zeitraum 1970–1989.
Background:
Inflammatory bowel disease (IBD) represents a dysregulation of the mucosal immune system. The pathogenesis of Crohn’s disease (CD) and ulcerative colitis (UC) is linked to the loss of intestinal tolerance and barrier function. The healthy mucosal immune system has previously been shown to be inert against food antigens. Since the small intestine is the main contact surface for antigens and therefore the immunological response, the present study served to analyse food-antigen-specific T cells in the peripheral blood of IBD patients.
Methods:
Peripheral blood mononuclear cells of CD, with an affected small intestine, and UC (colitis) patients, either active or in remission, were stimulated with the following food antigens: gluten, soybean, peanut and ovalbumin. Healthy controls and celiac disease patients were included as controls. Antigen-activated CD4+ T cells in the peripheral blood were analysed by a magnetic enrichment of CD154+ effector T cells and a cytometric antigen-reactive T-cell analysis (‘ARTE’ technology) followed by characterisation of the ef- fector response.
Results:
The effector T-cell response of antigen-specific T cells were compared between CD with small intestinal inflammation and UC where inflammation was restricted to the colon. Among all tested food antigens, the highest frequency of antigen-specific T cells (CD4+CD154+) was found for gluten. Celiac disease patients were included as control, since gluten has been identified as the disease- causing antigen. The highest frequency of gluten antigen-specific T cells was revealed in active CD when compared with UC, celiac disease on a gluten-free diet (GFD) and healthy controls. Ovalbuminspecific T cells were almost undetectable, whereas the reaction to soybean and peanut was slightly higher. But again, the strong- est reaction was observed in CD with small intestinal involvement compared with UC. Remarkably, in celiac disease on a GFD only
antigen-specific cells for gluten were detected. These gluten-specific T cells were characterised by up-regulation of the pro-inflammatory cytokines IFN-γ, IL-17A and TNF-α. IFN-g was exclusively elevated in CD patients with active disease. Gluten-specific T-cells expressing IL-17A were increased in all IBD patients. Furthermore, T cells of CD patients, independent of disease activity, revealed a high expression of the pro-inflammatory cytokine TNF-α.
Conclusion:
The ‘ARTE’-technique allows to analyse and quantify food antigen specific T cells in the peripheral blood of IBD patients indicating a potential therapeutic insight. These data provide evidence that small intestinal inflammation in CD is key for the development of a systemic pro-inflammatory effector T-cell response driven by food antigens.
Acute ankle sprain leads in 40% of all cases to chronic ankle instability (CAI). CAI is related to a variety of motor adaptations at the lower extremities. Previous investigations identified increased muscle activities while landing in CAI compared to healthy control participants. However, it remains unclear whether muscular alterations at the knee muscles are limited to the involved (unstable) ankle or are also present at the uninvolved leg. The latter might potentially indicate a risk of ankle sprain or future injury on the uninvolved leg. Purpose: To assess if there is a difference of knee muscle activities between the involved and uninvolved leg in participants with CAI during perturbed walking. Method: 10 participants (6 females; 4 males; 26±4 years; 169±9 cm; 65±7 kg) with unilateral CAI walked on a split-belt treadmill (1m/s) for 5 minutes of baseline walking and 6 minutes of perturbed walking (left and right side, each 10 perturbations). Electromyography (EMG) measurements were performed at biceps femoris (BF) and rectus femoris (RF). EMG amplitude (RMS; normalized to MVIC) were analyzed for 200ms pre-heel contact (Pre200), 100ms post heel contact (Post100) and 200ms after perturbation (Pert200). Data was analyzed by paired t-test/Wilcoxon test based on presence or absence of normal distribution (Bonferroni adjusted α level p≤ 0.0125). Results: No statistical difference was found between involved and uninvolved leg for RF (Pre200: 4±2% and 11± 22%, respectively, p= 0.878; Post100: 10± 5 and 18±31%, p=0.959; Pert200: 6±3% and 13±24%, p=0.721) as well as for BF (Pre200: 12±7% and 11±6, p=0.576; Post100: 10±7% and 9±7%, p=0.732; Pert200: 7±4 and 7±7%, p=0.386). Discussion: No side differences in muscle activity could be revealed for assessed feedforward and feedback responses (perturbed and unperturbed) in unilateral CAI. Reduced inter-individual variability of muscular activities at the involved leg might indicate a rather stereotypical response pattern. It remains to be investigated, whether muscular control at the knee is not affected by CAI, or whether both sides adapted in a similar style to the chronic condition at the ankle.
The Research Data Policy of the University of Potsdam has been ratified by Senate on September 25, 2019 and published in Amtliche Bekanntmachungen “Official Notices” September 30, 2019. It applies to all researchers and research support staff.
The Recommendations for the Handling of Research Data at the University of Potsdam specify and complement the Research Data Policy of the University of Potsdam. They are aimed at all researchers and research support staff have been adopted by Senate’s Commission for Research and Junior Academics (FNK) on on October 9, 2019.
This record provides a non-official translation of both documents from the German original.
Reinhard Hujer
(2020)
Recht im Ausnahmezustand
(2020)
Viele Länder weltweit haben im Bemühen, die Ausbreitung des Corona-Virus zu stoppen oder wenigstens zu verlangsamen, drastische Maßnahmen ergriffen: Schulen, Universitäten und kulturelle Einrichtungen sind geschlossen, öffentliche Plätze dürfen nicht betreten und das Zuhause nur in dringenden Fällen verlassen werden. Damit schränken einige der Maßnahmen sogar fundamentale Menschenrechte ein. Matthias Zimmermann sprach mit Prof. Dr. Andreas Zimmermann, dem Direktor des Potsdamer MenschenRechtsZentrums (MRZ), und Prof. Dr. Norman Weiß, der seit vielen Jahren am MRZ tätig ist, über die Menschenrechte im Ausnahmezustand.
Planstadt Doberlug
(2020)
Leben in der ehemaligen DDR
(2020)
History without borders
(2020)
Gomperz, Ephraim, Itzig
(2020)