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The interaction between endothelial cells and pericytes is crucial for the stabilization of newly formed vessels in angiogenesis. The comprehension of the mechanisms regulating peiicyte recruitment might open therapeutical perspectives on vascular-related pathologies. Sphingosine 1phosphate (SIP) is a bioactive sphingolipid that derives from sphingomyelin catabolism and regulates biological functions in cell survival, proliferation, and differentiation. In this study, we aimed to identify the role of SIP axis in the intercellular communication between human mesenchymal progenitor mesoangioblasts (MAB) and endothelial cells (human microvascular endothelial cells (HMVEC)) in the formation of capillary-like structures. We demonstrated that the SIP biosynthetic pathway brought about by sphingosine kinases (SK) SKI and SK2 as well as spinster homolog 2 (SPNS2) transporter in H-MVEC is crucial for MAB migration measured by Boyden chambers and for the formation and stabilization of capillary-like structures in a 3D Matrigel culture. Moreover, the conditioned medium (CM) harvested from HMVEC, where SKI, 5K2, and SPNS2 were down-regulated, exerted a significantly diminished effect on MAB capillary morphogenesis and migration. Notably, we demonstrated that S I Pi and Si p3 receptors were positively involved in CM-induced capillary-like formation and migration, while S I P2 exerted a negative role on CM-induced migratory action of MAB. Finally, SK inhibition as well as MAB SlPi and S1P3 down-regulation impaired HMVEC-MAB cross-talk significantly reducing in vivo angiogenesis evaluated by Matrigel plug assay. These findings individuate novel targets for the employment of MAB in vascular-related pathologic conditions.
In articolul cu titlul "Identități hibride în comunitatea imigranților români" sunt prezentate rezultate parțiale precum și anumite analize a citatelor vorbitorilor din proiectul meu de doctorat cu titlul Sprachkontakt, Migration und Variation: Die frankophone Integration von Rumänen in Paris nach 1989. Lingvistica migratoare observă mișcările migranților români după căderea cortinei de fier. Aceștia au fost nevoiți să suporte consecințele managementului eronat al sistemului comunist. Între 1989 și 2012 mii de români au pǎrǎsit țara. Începând de atunci numărul imigranților români în Paris a crescut în mod significant. Scopul acestei contribuții este ilustrarea identității sociale a comunității migrante. În centrul lucrării se află descrierea procesului cultural și integrării lingvistice prin observarea dezvoltării a noi identități hibride.
Renaissance des Bürgers
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Urbane Integration
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Turning Aliens into Citizens
(2011)
Inhalt: Empirical results of the survey ; A cumulative index of citizenship ; Jammu and Kashmir: Contesting “Indian” citizenship ; Conclusion
Grenzen als Sortiermaschinen
(2011)
Die Logik der Selektion
(2011)