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Background
Non-typhoid Salmonella Typhimurium (S. Typhimurium) accounts for a high number of registered salmonellosis cases, and O-serotyping is one important tool for monitoring epidemiology and spread of the disease. Moreover, variations in glucosylated O-antigens are related to immunogenicity and spread in the host. However, classical autoagglutination tests combined with the analysis of specific genetic markers cannot always reliably register phase variable glucose modifications expressed on Salmonella O-antigens and additional tools to monitor O-antigen glucosylation phenotypes of S. Typhimurium would be desirable.
Results
We developed a test for the phase variable O-antigen glucosylation state of S. Typhimurium using the tailspike proteins (TSP) of Salmonella phages 9NA and P22. We used this ELISA like tailspike adsorption (ELITA) assay to analyze a library of 44 Salmonella strains. ELITA was successful in discriminating strains that carried glucose 1-6 linked to the galactose of O-polysaccharide backbone (serotype O1) from non-glucosylated strains. This was shown by O-antigen compositional analyses of the respective strains with mass spectrometry and capillary electrophoresis. The ELITA test worked rapidly in a microtiter plate format and was highly O-antigen specific. Moreover, TSP as probes could also detect glucosylated strains in flow cytometry and distinguish multiphasic cultures differing in their glucosylation state.
Conclusions
Tailspike proteins contain large binding sites with precisely defined specificities and are therefore promising tools to be included in serotyping procedures as rapid serotyping agents in addition to antibodies. In this study, 9NA and P22TSP as probes could specifically distinguish glucosylation phenotypes of Salmonella on microtiter plate assays and in flow cytometry. This opens the possibility for flow sorting of cell populations for subsequent genetic analyses or for monitoring phase variations during large scale O-antigen preparations necessary for vaccine production.
Mental arithmetic exhibits various biases. Among those is a tendency to overestimate addition and to underestimate subtraction outcomes. Does such “operational momentum” (OM) also affect multiplication and division? Twenty-six adults produced lines whose lengths corresponded to the correct outcomes of multiplication and division problems shown in symbolic format. We found a reliable tendency to over-estimate division outcomes, i.e., reverse OM. We suggest that anchoring on the first operand (a tendency to use this number as a reference for further quantitative reasoning) contributes to cognitive biases in mental arithmetic.
Vermessung im Sonnensystem
(2017)
Die bisherigen Missionen ins Sonnensystem lieferten eine enorme Fülle an Daten in unterschiedlichen Formaten und in Form von Bildern und digitalen Messergebnissen. Die Oberflächenprozesse der planetaren Körper, die mit Hilfe dieser Daten erforscht werden können, sind äußerst vielfältig und reichen von Einschlagskratern über Vulkanismus und Tektonik zu allen Formen der Erosion und Sedimentation. Um diese Prozesse verstehen zu können werden Verfahren angewendet, die für die Datenanalyse auf der Erde entwickelt wurden. Allerdings ist es notwendig all diese Verfahren zum Teil mit erheblichem Aufwand und unter Berücksichtigung der jeweiligen physikalischen Rahmenbedingungen anzupassen. Die Entwicklung kartographischer Verfahren zur Abstraktion der hier angesprochenen Informationen, also die Erfassung, geomorphologische Analyse und Visualisierung planetarer Oberflächen und Prozesse, hat jedoch gerade erst begonnen. Um diese Entwicklungen voranzutreiben, hat das Deutsche Zentrum für Luft- und Raumfahrt in Kooperation mit der Universität Potsdam (Institut für Geographie, Fachgruppe Geoinformatik, Prof. Dr. Asche), im Rahmen von Dissertationen und Forschungsvorhaben, in einem ersten Schritt kartographische Analyseverfahren für den Mars und die Asteroiden Ceres und Vesta entwickelt.
Earth observation data have become an outstanding basis for analyzing environmental
aspects. The increasing availability of remote sensing data is accompanied
by an increasing user demand. Within the scope of the COOPERNICUS-initiative,
the automatic processing of remote sensing data is important for supplying value-
added-information products. The use of additional data like land-water-masks
in the context of deriving value-added information products can stabilize and
improve the product quality of information products.
The authors of this contribution would like to discuss different automated
processing algorithms which are based on land-water masks for value-added
data interpretation. These developments were supported or accompanied by Prof.
Hartmut Asche.
Das in den USA bereits weit verbreitete Predictive Policing, die vorhersagende
Polizeiarbeit, entwickelt sich seit zwei bis drei Jahren auch auf dem deutschen
Sicherheitsmarkt sehr dynamisch. Unter Nutzung und Weiterentwicklung von
Geographischen Informationssystemen sowie raumbasierter Algorithmen und
Modellierungen werden für beliebige Orte die Auftrittswahrscheinlichkeiten von
Straftaten ermittelt. In der Praxis erhält damit die Polizei ortsbezogene Hinweise
für die strategische Planung ihrer Einsätze. Für die Humangeographie und die
Geoinformatik ist Predictive Policing also ein äußerst interessantes Beobachtungsund
Betätigungsfeld, das in diesem Beitrag unter die Lupe genommen werden soll.
Dabei wird es weniger um die GIS-technischen und mathematisch-statistischen
Hintergründe des Predictive Policing gehen. Vielmehr sollen einige Gedanken
geäußert werden, weshalb sich dieses Instrument auf dem Sicherheitsmarkt etablieren
konnte und über welche Potenziale und Grenzen des Predictive Policing
von Vertreter(inne)n aus Politik, Polizei, Kriminalsoziologie und Geographie diskutiert
wird.
Statistics Canada, Canada’s national statistics agency, offers a suite of spatial
files for mapping and analysis of its various population data products. The following
article showcases possibilities and shortfalls of the existing spatial files
for mapping population data, and provides an overview of the structure of the
available boundary files from the regional to the dissemination block level. Due
to Canada’s highly dispersed population, mapping its distribution and density can
be challenging. Common mapping techniques such as the choropleth method are
suitable only for mapping spatially high resolution data such as data at the dissemination
area level. To allow for mapping of population data at less detailed levels
such as census divisions or provinces, Statistics Canada has created a so-called
ecumene boundary file which outlines the inhabited area of Canada and can be
used to more accurately visualize Canada’s population distribution and density.
Die Verwendung geographischer Namen in Karten und Atlanten ist ein in der
kartographischen Methodenlehre vernachlässigter Bereich, der aber Aufmerksamkeit
verdient, weil geographische Namen dort wichtige Funktionen erfüllen.
Sie identifizieren zwar nicht ein geographisches Objekt, erleichtern aber das
Kartenlesen, ermöglichen die Suche nach geographischen Objekten, weisen auf
Merkmale geographischer Objekte hin und lassen die kulturelle Einbettung eines
Ortes erkennen. Für Leser, denen der Name und der durch ihn bezeichnete Ort
bekannt sind, haben sie die zusätzliche Funktion von Etiketten und die Eigenschaft,
emotionale Bindungen zum Ort zu unterstützen. Es werden zudem sechs allgemeine
Grundsätze für die Verwendung von geographischen Namen in Atlanten genannt, ferner spezielle Grundsätze für die beiden Haupttypen von Atlanten, nämlich
wissenschaftliche Atlanten, die sich an ein internationales Publikum wenden, und populäre Atlanten, die v. a. ein heimisches Publikum ansprechen wollen.
Laudatio
(2017)
Hartmut Asche prägte über ein Vierteljahrhundert maßgeblich die Forschungsfelder der Geoinformation, Visualisierung und Kartographie. Die vorliegende Festschrift stellt eine würdige Gabe von Mitarbeiterinnen und Mitarbeitern des Institutes für Geographie der Universität Potsdam anlässlich seiner Emeritierung im März 2017 dar. International renommierte, Herrn Asches Karriere begleitende Autorinnen und Autoren, konnten für Fachbeiträge aus den Bereichen Geographie, Geoinformatik, Kartographie und Fernerkundung gewonnen werden. Es werden in fachlich hervorragender Weise Schwerpunkte umrissen, mit welchen Herr Asche sich in seiner von zahlreichen Höhepunkten geprägten wissenschaftlichen Karriere beschäftigte.
This is a brief survey of a constructive technique of analytic continuation related to an explicit integral formula of Golusin and Krylov (1933). It goes far beyond complex analysis and applies to the Cauchy problem for elliptic partial differential equations as well. As started in the classical papers, the technique is elaborated in generalised Hardy spaces also called Hardy-Smirnov spaces.
Trunk loading and back pain
(2017)
An essential function of the trunk is the compensation of external forces and loads in order to guarantee stability. Stabilising the trunk during sudden, repetitive loading in everyday tasks, as well as during performance is important in order to protect against injury. Hence, reduced trunk stability is accepted as a risk factor for the development of back pain (BP). An altered activity pattern including extended response and activation times as well as increased co-contraction of the trunk muscles as well as a reduced range of motion and increased movement variability of the trunk are evident in back pain patients (BPP). These differences to healthy controls (H) have been evaluated primarily in quasi-static test situations involving isolated loading directly to the trunk. Nevertheless, transferability to everyday, dynamic situations is under debate. Therefore, the aim of this project is to analyse 3-dimensional motion and neuromuscular reflex activity of the trunk as response to dynamic trunk loading in healthy (H) and back pain patients (BPP).
A measurement tool was developed to assess trunk stability, consisting of dynamic test situations. During these tests, loading of the trunk is generated by the upper and lower limbs with and without additional perturbation. Therefore, lifting of objects and stumbling while walking are adequate represents. With the help of a 12-lead EMG, neuromuscular activity of the muscles encompassing the trunk was assessed. In addition, three-dimensional trunk motion was analysed using a newly developed multi-segmental trunk model. The set-up was checked for reproducibility as well as validity. Afterwards, the defined measurement set-up was applied to assess trunk stability in comparisons of healthy and back pain patients.
Clinically acceptable to excellent reliability could be shown for the methods (EMG/kinematics) used in the test situations. No changes in trunk motion pattern could be observed in healthy adults during continuous loading (lifting of objects) of different weights. In contrast, sudden loading of the trunk through perturbations to the lower limbs during walking led to an increased neuromuscular activity and ROM of the trunk. Moreover, BPP showed a delayed muscle response time and extended duration until maximum neuromuscular activity in response to sudden walking perturbations compared to healthy controls. In addition, a reduced lateral flexion of the trunk during perturbation could be shown in BPP.
It is concluded that perturbed gait seems suitable to provoke higher demands on trunk stability in adults. The altered neuromuscular and kinematic compensation pattern in back pain patients (BPP) can be interpreted as increased spine loading and reduced trunk stability in patients. Therefore, this novel assessment of trunk stability is suitable to identify deficits in BPP. Assignment of affected BPP to therapy interventions with focus on stabilisation of the trunk aiming to improve neuromuscular control in dynamic situations is implied. Hence, sensorimotor training (SMT) to enhance trunk stability and compensation of unexpected sudden loading should be preferred.
Developing large software projects is a complicated task and can be demanding for developers. Continuous integration is common practice for reducing complexity. By integrating and testing changes often, changesets are kept small and therefore easily comprehensible. Travis CI is a service that offers continuous integration and continuous deployment in the cloud. Software projects are build, tested, and deployed using the Travis CI infrastructure without interrupting the development process. This report describes how Travis CI works, presents how time-driven, periodic building is implemented as well as how CI data visualization can be done, and proposes a way of dealing with dependency problems.
Background
Recently, the incidence rate of back pain (BP) in adolescents has been reported at 21%. However, the development of BP in adolescent athletes is unclear. Hence, the purpose of this study was to examine the incidence of BP in young elite athletes in relation to gender and type of sport practiced.
Methods
Subjective BP was assessed in 321 elite adolescent athletes (m/f 57%/43%; 13.2 ± 1.4 years; 163.4 ± 11.4 cm; 52.6 ± 12.6 kg; 5.0 ± 2.6 training yrs; 7.6 ± 5.3 training h/week). Initially, all athletes were free of pain. The main outcome criterion was the incidence of back pain [%] analyzed in terms of pain development from the first measurement day (M1) to the second measurement day (M2) after 2.0 ± 1.0 year. Participants were classified into athletes who developed back pain (BPD) and athletes who did not develop back pain (nBPD). BP (acute or within the last 7 days) was assessed with a 5-step face scale (face 1–2 = no pain; face 3–5 = pain). BPD included all athletes who reported faces 1 and 2 at M1 and faces 3 to 5 at M2. nBPD were all athletes who reported face 1 or 2 at both M1 and M2. Data was analyzed descriptively. Additionally, a Chi2 test was used to analyze gender- and sport-specific differences (p = 0.05).
Results
Thirty-two athletes were categorized as BPD (10%). The gender difference was 5% (m/f: 12%/7%) but did not show statistical significance (p = 0.15). The incidence of BP ranged between 6 and 15% for the different sport categories. Game sports (15%) showed the highest, and explosive strength sports (6%) the lowest incidence. Anthropometrics or training characteristics did not significantly influence BPD (p = 0.14 gender to p = 0.90 sports; r2 = 0.0825).
Conclusions
BP incidence was lower in adolescent athletes compared to young non-athletes and even to the general adult population. Consequently, it can be concluded that high-performance sports do not lead to an additional increase in back pain incidence during early adolescence. Nevertheless, back pain prevention programs should be implemented into daily training routines for sport categories identified as showing high incidence rates.
El Aleph
(2017)
Der argentinische Schriftsteller Jorge Luis Borges (1899-1986) gilt als ein Literat, der bereits in seinen Werken der 30er und 40er Jahre des 20. Jahrhunderts Strukturen geschaffen hat, die später die Postmoderne prägen sollten. Foucault hat sich auf ihn berufen. Borges Erzählungen sind insbesondere von intertextuellen Bezugnahmen und sich in Paradoxien verstrickende Narrative durchzogen. Die Folge ist ein dezentrierter sowie dialogisierender Text, der keine eindeutige Aussage hervorbringt, sondern in einer vielstimmigen und unabgeschlossenen Textauslegung zur Wirkung kommt.
Die vorliegende Studie stellt zur Diskussion, ob ein wesentlicher Grund für Borges’ innovatives, die literarische Postmoderne prägendes Textkonzept darin gesehen werden kann, dass sich der argentinische Schriftsteller nachweislich mit jüdischer Schriftkultur auseinandergesetzt hat. Geht man davon aus, dass die in jüdischer Tradition kultivierte mehrschichtige Textdeutung zugleich einen permanenten, unendlichen Rezeptionsprozess zur Folge hat wird deutlich, dass diese Tradition nicht nur kompatibel zu Borges’ Literatur ist, sondern auch zahlreiche Reflexionen in der modernen Literatur und Literaturforschung angeregt hat.