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The "Lomonosov" space project is lead by Lomonosov Moscow State University in collaboration with the following key partners: Joint Institute for Nuclear Research, Russia, University of California, Los Angeles (USA), University of Pueblo (Mexico), Sungkyunkwan University (Republic of Korea) and with Russian space industry organi-zations to study some of extreme phenomena in space related to astrophysics, astroparticle physics, space physics, and space biology. The primary goals of this experiment are to study:
-Ultra-high energy cosmic rays (UHECR) in the energy range of the Greizen-ZatsepinKuzmin (GZK) cutoff;
-Ultraviolet (UV) transient luminous events in the upper atmosphere;
-Multi-wavelength study of gamma-ray bursts in visible, UV, gamma, and X-rays;
-Energetic trapped and precipitated radiation (electrons and protons) at low-Earth orbit (LEO) in connection with global geomagnetic disturbances;
-Multicomponent radiation doses along the orbit of spacecraft under different geomagnetic conditions and testing of space segments of optical observations of space-debris and other space objects;
-Instrumental vestibular-sensor conflict of zero-gravity phenomena during space flight.
This paper is directed towards the general description of both scientific goals of the project and scientific equipment on board the satellite. The following papers of this issue are devoted to detailed descriptions of scientific instruments.
A new sedimentary sequence from Lago di Venere on Pantelleria Island, located in the Strait of Sicily between Tunisia and Sicily was recovered. The lake is located in the coastal infra-Mediterranean vegetation belt at 2 m a.s.l. Pollen, charcoal and sedimentological analyses are used to explore linkages among vegetation, fire and climate at a decadal scale over the past 1200 years. A dry period from ad 800 to 1000 that corresponds to the Medieval Warm Period' (WMP) is inferred from sedimentological analysis. The high content of carbonate recorded in this period suggests a dry phase, when the ratio of evaporation/precipitation was high. During this period the island was dominated by thermophilous and drought-tolerant taxa, such as Quercus ilex, Olea, Pistacia and Juniperus. A marked shift in the sediment properties is recorded at ad 1000, when carbonate content became very low suggesting wetter conditions until ad 1850-1900. Broadly, this period coincides with the Little Ice Age' (LIA), which was characterized by wetter and colder conditions in Europe. During this time rather mesic conifers (i.e. Pinus pinaster), shrubs and herbs (e.g. Erica arborea and Selaginella denticulata) expanded, whereas more drought-adapted species (e.g. Q. ilex) declined. Charcoal data suggest enhanced fire activity during the LIA probably as a consequence of anthropogenic burning and/or more flammable fuel (e.g. resinous Pinus biomass). The last century was characterized by a shift to high carbonate content, indicating a change towards drier conditions, and re-expansion of Q. ilex and Olea. The post-LIA warming is in agreement with historical documents and meteorological time series. Vegetation dynamics were co-determined by agricultural activities on the island. Anthropogenic indicators (e.g. Cerealia-type, Sporormiella) reveal the importance of crops and grazing on the island. Our pollen data suggest that extensive logging caused the local extinction of deciduous Quercus pubescens around ad1750.
Planar bis(1,2-dithiooxalato)nickelate(II), [Ni(dto)]2− reacts in aqueous solutions with lanthanide ions (Ln3+) to form pentanuclear, hetero-bimetallic complexes of the general composition [{Ln(H2O)n}2{Ni(dto)2}3]·xH2O. (n = 4 or 5; x = 9–12). The complex [{Ho(H2O)5}2{Ni(dto)2}3]·10H2O, Ho2Ni3, was synthesized and characterized by single crystal X-ray structure analysis and powder diffraction. The Ho2Ni3 complex crystallizes as monoclinic crystals in the space group P21/c. The channels and cavities, appearing in the crystal packing of the complex molecules, are occupied by a varying amount of non-coordinated water molecules.
A Case for Serious Play
(2017)
Flooding is assessed as the most important natural hazard in Europe, causing thousands of deaths, affecting millions of people and accounting for large economic losses in the past decade. Little is known about the damage processes associated with extreme rainfall in cities, due to a lack of accurate, comparable and consistent damage data. The objective of this study is to investigate the impacts of extreme rainfall on residential buildings and how affected households coped with these impacts in terms of precautionary and emergency actions. Analyses are based on a unique dataset of damage characteristics and a wide range of potential damage explaining variables at the household level, collected through computer-aided telephone interviews (CATI) and an online survey. Exploratory data analyses based on a total of 859 completed questionnaires in the cities of Munster (Germany) and Amsterdam (the Netherlands) revealed that the uptake of emergency measures is related to characteristics of the hazardous event. In case of high water levels, more efforts are made to reduce damage, while emergency response that aims to prevent damage is less likely to be effective. The difference in magnitude of the events in Munster and Amsterdam, in terms of rainfall intensity and water depth, is probably also the most important cause for the differences between the cities in terms of the suffered financial losses. Factors that significantly contributed to damage in at least one of the case studies are water contamination, the presence of a basement in the building and people's awareness of the upcoming event. Moreover, this study confirms conclusions by previous studies that people's experience with damaging events positively correlates with precautionary behaviour. For improving future damage data acquisition, we recommend the inclusion of cell phones in a CATI survey to avoid biased sampling towards certain age groups.
Introduction
Varus knee alignment has been identified as a risk factor for the progression of medial knee osteoarthritis. However, the underlying mechanisms have not been elucidated yet in children. Thus, the aims of the present study were to examine differences in ground reaction forces, loading rate, impulses, and free moment values during running in children with and without genu varus.
Methods
Thirty-six boys aged 9–14 volunteered to participate in this study. They were divided in two age-matched groups (genu varus versus healthy controls). Body weight adjusted three dimensional kinetic data (Fx, Fy, Fz) were collected during running at preferred speed using two Kistler force plates for the dominant and non-dominant limb.
Results
Individuals with knee genu varus produced significantly higher (p = .01; d = 1.09; 95%) body weight adjusted ground reaction forces in the lateral direction (Fx) of the dominant limb compared to controls. On the non-dominant limb, genu varus patients showed significantly higher body weight adjusted ground reaction forces values in the lateral (p = .01; d = 1.08; 86%) and medial (p < .001; d = 1.55; 102%) directions (Fx). Further, genu varus patients demonstrated 55% and 36% greater body weight adjusted loading rates in the dominant (p < .001; d = 2.09) and non-dominant (p < .001; d = 1.02) leg, respectively. No significant between-group differences were observed for adjusted free moment values (p>.05). Discussion Higher mediolateral ground reaction forces and vertical loading rate amplitudes in boys with genu varus during running at preferred running speed may accelerate the development of progressive joint degeneration in terms of the age at knee osteoarthritis onset. Therefore, practitioners and therapists are advised to conduct balance and strength training programs to improve lower limb alignment and mediolateral control during dynamic movements.
Accurate time series representation of paleoclimatic proxy records is challenging because such records involve dating errors in addition to proxy measurement errors. Rigorous attention is rarely given to age uncertainties in paleoclimatic research, although the latter can severely bias the results of proxy record analysis. Here, we introduce a Bayesian approach to represent layer-counted proxy records - such as ice cores, sediments, corals, or tree rings - as sequences of probability distributions on absolute, error-free time axes. The method accounts for both proxy measurement errors and uncertainties arising from layer-counting-based dating of the records. An application to oxygen isotope ratios from the North Greenland Ice Core Project (NGRIP) record reveals that the counting errors, although seemingly small, lead to substantial uncertainties in the final representation of the oxygen isotope ratios. In particular, for the older parts of the NGRIP record, our results show that the total uncertainty originating from dating errors has been seriously underestimated. Our method is next applied to deriving the overall uncertainties of the Suigetsu radiocarbon comparison curve, which was recently obtained from varved sediment cores at Lake Suigetsu, Japan. This curve provides the only terrestrial radiocarbon comparison for the time interval 12.5-52.8 kyr BP. The uncertainties derived here can be readily employed to obtain complete error estimates for arbitrary radiometrically dated proxy records of this recent part of the last glacial interval.
Dark matter, DM, has not yet been directly observed, but it has a very solid theoretical basis. There are observations that provide indirect evidence, like galactic rotation curves that show that the galaxies are rotating too fast to keep their constituent parts, and galaxy clusters that bends the light coming from behind-lying galaxies more than expected with respect to the mass that can be calculated from what can be visibly seen. These observations, among many others, can be explained with theories that include DM. The missing piece is to detect something that can exclusively be explained by DM. Direct observation in a particle accelerator is one way and indirect detection using telescopes is another. This thesis is focused on the latter method.
The Very Energetic Radiation Imaging Telescope Array System, V ERITAS, is a telescope array that detects Cherenkov radiation. Theory predicts that DM particles annihilate into, e.g., a γγ pair and create a distinctive energy spectrum when detected by such telescopes, e.i., a monoenergetic line at the same energy as the particle mass. This so called ”smoking-gun” signature is sought with a sliding window line search within the sub-range ∼ 0.3 − 10 TeV of the VERITAS energy range, ∼ 0.01 − 30 TeV.
Standard analysis within the VERITAS collaboration uses Hillas analysis and look-up tables, acquired by analysing particle simulations, to calculate the energy of the particle causing the Cherenkov shower. In this thesis, an improved analysis method has been used. Modelling each shower as a 3Dgaussian should increase the energy recreation quality. Five dwarf spheroidal galaxies were chosen as targets with a total of ∼ 224 hours of data. The targets were analysed individually and stacked. Particle simulations were based on two simulation packages, CARE and GrISU.
Improvements have been made to the energy resolution and bias correction, up to a few percent each, in comparison to standard analysis. Nevertheless, no line with a relevant significance has been detected. The most promising line is at an energy of ∼ 422 GeV with an upper limit cross section of 8.10 · 10^−24 cm^3 s^−1 and a significance of ∼ 2.73 σ, before trials correction and ∼ 1.56 σ after. Upper limit cross sections have also been calculated for the γγ annihilation process and four other outcomes. The limits are in line with current limits using other methods, from ∼ 8.56 · 10^−26 − 6.61 · 10^−23 cm^3s^−1. Future larger telescope arrays, like the upcoming Cherenkov Telescope Array, CTA, will provide better results with the help of this analysis method.
Past climatic change can be reconstructed from sedimentary archives by a number of proxies. However, few methods exist to directly estimate hydrological changes and even fewer result in quantitative data, impeding our understanding of the timing, magnitude and mechanisms of hydrological changes.
Here we present a novel approach based on delta H-2 values of sedimentary lipid biomarkers in combination with plant physiological modeling to extract quantitative information on past changes in relative humidity. Our initial application to an annually laminated lacustrine sediment sequence from western Europe deposited during the Younger Dryas cold period revealed relative humidity changes of up to 15% over sub-centennial timescales, leading to major ecosystem changes, in agreement with palynological data from the region. We show that by combining organic geochemical methods and mechanistic plant physiological models on well characterized lacustrine archives it is possible to extract quantitative ecohydrological parameters from sedimentary lipid biomarker delta H-2 data.
Nowadays, graph data models are employed, when relationships between entities have to be stored and are in the scope of queries. For each entity, this graph data model locally stores relationships to adjacent entities. Users employ graph queries to query and modify these entities and relationships. These graph queries employ graph patterns to lookup all subgraphs in the graph data that satisfy certain graph structures. These subgraphs are called graph pattern matches. However, this graph pattern matching is NP-complete for subgraph isomorphism. Thus, graph queries can suffer a long response time, when the number of entities and relationships in the graph data or the graph patterns increases.
One possibility to improve the graph query performance is to employ graph views that keep ready graph pattern matches for complex graph queries for later retrieval. However, these graph views must be maintained by means of an incremental graph pattern matching to keep them consistent with the graph data from which they are derived, when the graph data changes. This maintenance adds subgraphs that satisfy a graph pattern to the graph views and removes subgraphs that do not satisfy a graph pattern anymore from the graph views.
Current approaches for incremental graph pattern matching employ Rete networks. Rete networks are discrimination networks that enumerate and maintain all graph pattern matches of certain graph queries by employing a network of condition tests, which implement partial graph patterns that together constitute the overall graph query. Each condition test stores all subgraphs that satisfy the partial graph pattern. Thus, Rete networks suffer high memory consumptions, because they store a large number of partial graph pattern matches. But, especially these partial graph pattern matches enable Rete networks to update the stored graph pattern matches efficiently, because the network maintenance exploits the already stored partial graph pattern matches to find new graph pattern matches. However, other kinds of discrimination networks exist that can perform better in time and space than Rete networks. Currently, these other kinds of networks are not used for incremental graph pattern matching.
This thesis employs generalized discrimination networks for incremental graph pattern matching. These discrimination networks permit a generalized network structure of condition tests to enable users to steer the trade-off between memory consumption and execution time for the incremental graph pattern matching. For that purpose, this thesis contributes a modeling language for the effective definition of generalized discrimination networks. Furthermore, this thesis contributes an efficient and scalable incremental maintenance algorithm, which updates the (partial) graph pattern matches that are stored by each condition test. Moreover, this thesis provides a modeling evaluation, which shows that the proposed modeling language enables the effective modeling of generalized discrimination networks. Furthermore, this thesis provides a performance evaluation, which shows that a) the incremental maintenance algorithm scales, when the graph data becomes large, and b) the generalized discrimination network structures can outperform Rete network structures in time and space at the same time for incremental graph pattern matching.
A comprehensive hydrometeorological dataset is presented spanning the period 1 January 201131 December 2014 to improve the understanding of the hydrological processes leading to flash floods and the relation between rainfall, runoff, erosion and sediment transport in a mesoscale catchment (Auzon, 116 km(2)) of the Mediterranean region. Badlands are present in the Auzon catchment and well connected to high-gradient channels of bedrock rivers which promotes the transfer of suspended solids downstream. The number of observed variables, the various sensors involved (both in situ and remote) and the space-time resolution (similar to km(2), similar to min) of this comprehensive dataset make it a unique contribution to research communities focused on hydrometeorology, surface hydrology and erosion. Given that rainfall is highly variable in space and time in this region, the observation system enables assessment of the hydrological response to rainfall fields. Indeed, (i) rainfall data are provided by rain gauges (both a research network of 21 rain gauges with a 5 min time step and an operational network of 10 rain gauges with a 5 min or 1 h time step), S-band Doppler dual-polarization radars (1 km(2), 5 min resolution), disdrometers (16 sensors working at 30 s or 1 min time step) and Micro Rain Radars (5 sensors, 100m height resolution). Additionally, during the special observation period (SOP-1) of the HyMeX (Hydrological Cycle in the Mediterranean Experiment) project, two X-band radars provided precipitation measurements at very fine spatial and temporal scales (1 ha, 5 min). (ii) Other meteorological data are taken from the operational surface weather observation stations of Meteo-France (including 2m air temperature, atmospheric pressure, 2 m relative humidity, 10m wind speed and direction, global radiation) at the hourly time resolution (six stations in the region of interest). (iii) The monitoring of surface hydrology and suspended sediment is multi-scale and based on nested catchments. Three hydrometric stations estimate water discharge at a 2-10 min time resolution. Two of these stations also measure additional physico-chemical variables (turbidity, temperature, conductivity) and water samples are collected automatically during floods, allowing further geochemical characterization of water and suspended solids. Two experimental plots monitor overland flow and erosion at 1 min time resolution on a hillslope with vineyard. A network of 11 sensors installed in the intermittent hydrographic network continuously measures water level and water temperature in headwater subcatchments (from 0.17 to 116 km(2)) at a time resolution of 2-5 min. A network of soil moisture sensors enables the continuous measurement of soil volumetric water content at 20 min time resolution at 9 sites. Additionally, concomitant observations (soil moisture measurements and stream gauging) were performed during floods between 2012 and 2014. Finally, this dataset is considered appropriate for understanding the rainfall variability in time and space at fine scales, improving areal rainfall estimations and progressing in distributed hydrological and erosion modelling.
Background: Leishmania tarentolae, a unicellular eukaryotic protozoan, has been established as a novel host for recombinant protein production in recent years. Current protocols for protein expression in Leishmania are, however, time consuming and require extensive lab work in order to identify well-expressing cell lines. Here we established an alternative protein expression work-flow that employs recently engineered infrared fluorescence protein (IFP) as a suitable and easy-to-handle reporter protein for recombinant protein expression in Leishmania. As model proteins we tested three proteins from the plant Arabidopsis thaliana, including a NAC and a type-B ARR transcription factor.
Results: IFP and IFP fusion proteins were expressed in Leishmania and rapidly detected in cells by deconvolution microscopy and in culture by infrared imaging of 96-well microtiter plates using small cell culture volumes (2 mu L - 100 mu L). Motility, shape and growth of Leishmania cells were not impaired by intracellular accumulation of IFP. In-cell detection of IFP and IFP fusion proteins was straightforward already at the beginning of the expression pipeline and thus allowed early pre-selection of well-expressing Leishmania clones. Furthermore, IFP fusion proteins retained infrared fluorescence after electrophoresis in denaturing SDS-polyacrylamide gels, allowing direct in-gel detection without the need to disassemble cast protein gels. Thus, parameters for scaling up protein production and streamlining purification routes can be easily optimized when employing IFP as reporter.
Conclusions: Using IFP as biosensor we devised a protocol for rapid and convenient protein expression in Leishmania tarentolae. Our expression pipeline is superior to previously established methods in that it significantly reduces the hands-on-time and work load required for identifying well-expressing clones, refining protein production parameters and establishing purification protocols. The facile in-cell and in-gel detection tools built on IFP make Leishmania amenable for high-throughput expression of proteins from plant and animal sources.
Recognizing, understanding, and responding to quantities are considerable skills for human beings. We can easily communicate quantities, and we are extremely efficient in adapting our behavior to numerical related tasks. One usual task is to compare quantities. We also use symbols like digits in numerical-related tasks. To solve tasks including digits, we must to rely on our previously learned internal number representations.
This thesis elaborates on the process of number comparison with the use of noisy mental representations of numbers, the interaction of number and size representations and how we use mental number representations strategically. For this, three studies were carried out.
In the first study, participants had to decide which of two presented digits was numerically larger. They had to respond with a saccade in the direction of the anticipated answer. Using only a small set of meaningfully interpretable parameters, a variant of random walk models is described that accounts for response time, error rate, and variance of response time for the full matrix of 72 digit pairs. In addition, the used random walk model predicts a numerical distance effect even for error response times and this effect clearly occurs in the observed data. In relation to corresponding correct answers error responses were systematically faster. However, different from standard assumptions often made in random walk models, this account required that the distributions of step sizes of the induced random walks be asymmetric to account for this asymmetry between correct and incorrect responses.
Furthermore, the presented model provides a well-defined framework to investigate the nature and scale (e.g., linear vs. logarithmic) of the mapping of numerical magnitude onto its internal representation. In comparison of the fits of proposed models with linear and logarithmic mapping, the logarithmic mapping is suggested to be prioritized.
Finally, we discuss how our findings can help interpret complex findings (e.g., conflicting speed vs. accuracy trends) in applied studies that use number comparison as a well-established diagnostic tool. Furthermore, a novel oculomotoric effect is reported, namely the saccadic overschoot effect. The participants responded by saccadic eye movements and the amplitude of these saccadic responses decreases with numerical distance.
For the second study, an experimental design was developed that allows us to apply the signal detection theory to a task where participants had to decide whether a presented digit was physically smaller or larger. A remaining question is, whether the benefit in (numerical magnitude – physical size) congruent conditions is related to a better perception than in incongruent conditions. Alternatively, the number-size congruency effect is mediated by response biases due to numbers magnitude. The signal detection theory is a perfect tool to distinguish between these two alternatives. It describes two parameters, namely sensitivity and response bias. Changes in the sensitivity are related to the actual task performance due to real differences in perception processes whereas changes in the response bias simply reflect strategic implications as a stronger preparation (activation) of an anticipated answer. Our results clearly demonstrate that the number-size congruency effect cannot be reduced to mere response bias effects, and that genuine sensitivity gains for congruent number-size pairings contribute to the number-size congruency effect.
Third, participants had to perform a SNARC task – deciding whether a presented digit was odd or even. Local transition probability of irrelevant attributes (magnitude) was varied while local transition probability of relevant attributes (parity) and global probability occurrence of each stimulus were kept constantly. Participants were quite sensitive in recognizing the underlying local transition probability of irrelevant attributes. A gain in performance was observed for actual repetitions of the irrelevant attribute in relation to changes of the irrelevant attribute in high repetition conditions compared to low repetition conditions. One interpretation of these findings is that information about the irrelevant attribute (magnitude) in the previous trial is used as an informative precue, so that participants can prepare early processing stages in the current trial, with the corresponding benefits and costs typical of standard cueing studies.
Finally, the results reported in this thesis are discussed in relation to recent studies in numerical cognition.
The unusual mix of morphological traits displayed by extinct South American native ungulates (SANUs) confounded both Charles Darwin, who first discovered them, and Richard Owen, who tried to resolve their relationships. Here we report an almost complete mitochondrial genome for the litoptern Macrauchenia. Our dated phylogenetic tree places Macrauchenia as sister to Perissodactyla, but close to the radiation of major lineages within Laurasiatheria. This position is consistent with a divergence estimate of B66Ma (95% credibility interval, 56.64-77.83 Ma) obtained for the split between Macrauchenia and other Panperissodactyla. Combined with their morphological distinctiveness, this evidence supports the positioning of Litopterna (possibly in company with other SANU groups) as a separate order within Laurasiatheria. We also show that, when using strict criteria, extinct taxa marked by deep divergence times and a lack of close living relatives may still be amenable to palaeogenomic analysis through iterative mapping against more distant relatives.
Advanced mechatronic systems have to integrate existing technologies from mechanical, electrical and software engineering. They must be able to adapt their structure and behavior at runtime by reconfiguration to react flexibly to changes in the environment. Therefore, a tight integration of structural and behavioral models of the different domains is required. This integration results in complex reconfigurable hybrid systems, the execution logic of which cannot be addressed directly with existing standard modeling, simulation, and code-generation techniques. We present in this paper how our component-based approach for reconfigurable mechatronic systems, M ECHATRONIC UML, efficiently handles the complex interplay of discrete behavior and continuous behavior in a modular manner. In addition, its extension to even more flexible reconfiguration cases is presented.
The polar and subtropical jet streams are strong upper-level winds with a crucial influence on weather throughout the Northern Hemisphere midlatitudes. In particular, the polar jet is located between cold arctic air to the north and warmer subtropical air to the south. Strongly meandering states therefore often lead to extreme surface weather.
Some algorithms exist which can detect the 2-D (latitude and longitude) jets' core around the hemisphere, but all of them use a minimal threshold to determine the subtropical and polar jet stream. This is particularly problematic for the polar jet stream, whose wind velocities can change rapidly from very weak to very high values and vice versa.
We develop a network-based scheme using Dijkstra's shortest-path algorithm to detect the polar and subtropical jet stream core. This algorithm not only considers the commonly used wind strength for core detection but also takes wind direction and climatological latitudinal position into account. Furthermore, it distinguishes between polar and subtropical jet, and between separate and merged jet states.
The parameter values of the detection scheme are optimized using simulated annealing and a skill function that accounts for the zonal-mean jet stream position (Rikus, 2015). After the successful optimization process, we apply our scheme to reanalysis data covering 1979-2015 and calculate seasonal-mean probabilistic maps and trends in wind strength and position of jet streams.
We present longitudinally defined probability distributions of the positions for both jets for all on the Northern Hemisphere seasons. This shows that winter is characterized by two well-separated jets over Europe and Asia (ca. 20 degrees W to 140 degrees E). In contrast, summer normally has a single merged jet over the western hemisphere but can have both merged and separated jet states in the eastern hemisphere.
With this algorithm it is possible to investigate the position of the jets' cores around the hemisphere and it is therefore very suitable to analyze jet stream patterns in observations and models, enabling more advanced model-validation.
In his “Essay on the Fluctuations in the Supplies of Gold” (1838) Humboldt presents a global history of the flow of precious metals from antiquity to the 19th century. This paper traces Humboldt’s economic thinking within his natural and historical research, starting with an outline of his educational background which incorporated late mercantilist and early liberal influences. It then discusses a world map and four charts drawn by Humboldt, which combine historical and contemporary statistical data into a cartographical vision of a global economic circuit. In a next step, the article explores Humboldt’s application of natural and historical research methods in the field of political economy, using the example of his 1838 essay. Finally, the article addresses Humboldt’s discussion of platinum, a precious metal whose limited natural distribution contradicted the idea of free global exchange.
In a bounded domain with smooth boundary in R^3 we consider the stationary Maxwell equations
for a function u with values in R^3 subject to a nonhomogeneous condition
(u,v)_x = u_0 on
the boundary, where v is a given vector field and u_0 a function on the boundary. We specify this problem within the framework of the Riemann-Hilbert boundary value problems for the Moisil-Teodorescu system. This latter is proved to satisfy the Shapiro-Lopaniskij condition if an only if the vector v is at no point tangent to the boundary. The Riemann-Hilbert problem for the Moisil-Teodorescu system fails to possess an adjoint boundary value problem with respect to the Green formula, which satisfies the Shapiro-Lopatinskij condition. We develop the construction of Green formula to get a proper concept of adjoint boundary value problem.
Fixational eye movements show scaling behaviour of the positional mean-squared displacement with a characteristic transition from persistence to antipersistence for increasing time-lag. These statistical patterns were found to be mainly shaped by microsaccades (fast, small-amplitude movements). However, our re-analysis of fixational eye-movement data provides evidence that the slow component (physiological drift) of the eyes exhibits scaling behaviour of the mean-squared displacement that varies across human participants. These results suggest that drift is a correlated movement that interacts with microsaccades. Moreover, on the long time scale, the mean-squared displacement of the drift shows oscillations, which is also present in the displacement auto-correlation function. This finding lends support to the presence of time-delayed feedback in the control of drift movements. Based on an earlier non-linear delayed feedback model of fixational eye movements, we propose and discuss different versions of a new model that combines a self-avoiding walk with time delay. As a result, we identify a model that reproduces oscillatory correlation functions, the transition from persistence to antipersistence, and microsaccades.
Processes driving the production, transformation and transport of methane (CH4) in wetland ecosystems are highly complex. We present a simple calculation algorithm to separate open-water CH4 fluxes measured with automatic chambers into diffusion- and ebullition-derived components. This helps to reveal underlying dynamics, to identify potential environmental drivers and, thus, to calculate reliable CH4 emission estimates. The flux separation is based on identification of ebullition-related sudden concentration changes during single measurements. Therefore, a variable ebullition filter is applied, using the lower and upper quartile and the interquartile range (IQR). Automation of data processing is achieved by using an established R script, adjusted for the purpose of CH4 flux calculation. The algorithm was validated by performing a laboratory experiment and tested using flux measurement data (July to September 2013) from a former fen grassland site, which converted into a shallow lake as a result of rewetting. Ebullition and diffusion contributed equally (46 and 55 %) to total CH4 emissions, which is comparable to ratios given in the literature. Moreover, the separation algorithm revealed a concealed shift in the diurnal trend of diffusive fluxes throughout the measurement period. The water temperature gradient was identified as one of the major drivers of diffusive CH4 emissions, whereas no significant driver was found in the case of erratic CH4 ebullition events.
In this combined theoretical and experimental study we report a full analysis of the resonant inelastic X-ray scattering (RIXS) spectra of H2O, D2O and HDO. We demonstrate that electronically-elastic RIXS has an inherent capability to map the potential energy surface and to perform vibrational analysis of the electronic ground state in multimode systems. We show that the control and selection of vibrational excitation can be performed by tuning the X-ray frequency across core-excited molecular bands and that this is clearly reflected in the RIXS spectra. Using high level ab initio electronic structure and quantum nuclear wave packet calculations together with high resolution RIXS measurements, we discuss in detail the mode coupling, mode localization and anharmonicity in the studied systems.
For various experimental applications, microbial cultures at defined, constant densities are highly advantageous over simple batch cultures. Due to high costs, however, devices for continuous culture at freely defined densities still experience limited use. We have developed a small-scale turbidostat for research purposes, which is manufactured from inexpensive components and 3D printed parts. A high degree of spatial system integration and a graphical user interface provide user-friendly operability. The used optical density feedback control allows for constant continuous culture at a wide range of densities and offers to vary culture volume and dilution rates without additional parametrization. Further, a recursive algorithm for on-line growth rate estimation has been implemented. The employed Kalman filtering approach based on a very general state model retains the flexibility of the used control type and can be easily adapted to other bioreactor designs. Within several minutes it can converge to robust, accurate growth rate estimates. This is particularly useful for directed evolution experiments or studies on metabolic challenges, as it allows direct monitoring of the population fitness.
One of the most striking features of recent public sector reform in Europe is privatization. This development raises questions of accountability: By whom and for what are managers of private for-profit organizations delivering public goods held accountable? Analyzing accountability mechanisms through the lens of an institutional organizational approach and on the empirical basis of hospital privatization in Germany, the article contributes to the empirical and theoretical understanding of public accountability of private actors. The analysis suggests that accountability is not declining but rather multiplying. The shifts in the locus and content of accountability cause organizational stress for private hospitals.
Accountability can be conceptualized as institutionalized mechanisms obliging actors to explain their conduct to different forums, which can pose questions and impose sanctions. This article analyses different crises' in immigration policies in Norway, Denmark and Germany along a descriptive framework of five different accountability types: political, administrative, legal, professional and social accountability. The exchanges of information, debate and their consequences between an actor and a forum are crucial to understanding how political-administrative action is carried out in critical situations. First, accountability dynamics emphasize conventional norms and values regarding policy change and, second, formal political responsibility does not necessarily lead to political consequences such as minister resignations in cases of misbehaviour. Consequences strongly depend on how accountability dynamics take place.
School adjustment determines long-term adjustment in society. Yet, immigrant youth do better in some countries than in others. Drawing on acculturation research (Berry, 1997; Ward, 2001) and self-determination theory (Ryan and Deci, 2000), we investigated indirect effects of adolescent immigrants’ acculturation orientations on school adjustment (school-related attitudes, truancy, and mathematics achievement) through school belonging. Analyses were based on data from the Programme for International Student Assessment from six European countries, which were combined into three clusters based on their migrant integration and multicultural policies: Those with the most supportive policies (Belgium and Finland), those with moderately supportive policies (Italy and Portugal), and those with the most unsupportive policies (Denmark and Slovenia). In a multigroup path model, we confirmed most associations. As expected, mainstream orientation predicted higher belonging and better outcomes in all clusters, whereas the added value of students’ ethnic orientation was only observed in some clusters. Results are discussed in terms of differences in acculturative climate and policies between countries of settlement.
Continuous exercise (CON) and high-intensity interval exercise (HIIE) can be safely performed with type 1 diabetes mellitus (T1DM). Additionally, continuous glucose monitoring (CGM) systems may serve as a tool to reduce the risk of exercise-induced hypoglycemia. It is unclear if CGM is accurate during CON and HIIE at different mean workloads. Seven T1DM patients performed CON and HIIE at 5% below (L) and above (M) the first lactate turn point (LTP1), and 5% below the second lactate turn point (LTP2) (H) on a cycle ergometer. Glucose was measured via CGM and in capillary blood (BG). Differences were found in comparison of CGM vs. BG in three out of the six tests (p < 0.05). In CON, bias and levels of agreement for L, M, and H were found at: 0.85 (−3.44, 5.15) mmol·L−1, −0.45 (−3.95, 3.05) mmol·L−1, −0.31 (−8.83, 8.20) mmol·L−1 and at 1.17 (−2.06, 4.40) mmol·L−1, 0.11 (−5.79, 6.01) mmol·L−1, 1.48 (−2.60, 5.57) mmol·L−1 in HIIE for the same intensities. Clinically-acceptable results (except for CON H) were found. CGM estimated BG to be clinically acceptable, except for CON H. Additionally, using CGM may increase avoidance of exercise-induced hypoglycemia, but usual BG control should be performed during intense exercise.
Landscape evolution models (LEMs) allow the study of earth surface responses to changing climatic and tectonic forcings. While much effort has been devoted to the development of LEMs that simulate a wide range of processes, the numerical accuracy of these models has received less attention. Most LEMs use first-order accurate numerical methods that suffer from substantial numerical diffusion. Numerical diffusion particularly affects the solution of the advection equation and thus the simulation of retreating landforms such as cliffs and river knickpoints. This has potential consequences for the integrated response of the simulated landscape. Here we test a higher-order flux-limiting finite volume method that is total variation diminishing (TVD-FVM) to solve the partial differential equations of river incision and tectonic displacement. We show that using the TVD-FVM to simulate river incision significantly influences the evolution of simulated landscapes and the spatial and temporal variability of catchment-wide erosion rates. Furthermore, a two-dimensional TVD-FVM accurately simulates the evolution of landscapes affected by lateral tectonic displacement, a process whose simulation was hitherto largely limited to LEMs with flexible spatial discretization. We implement the scheme in TTLEM (TopoToolbox Landscape Evolution Model), a spatially explicit, raster-based LEM for the study of fluvially eroding landscapes in TopoToolbox 2.
Across currents
(2017)
This cumulative dissertation consists of five chapters. In terms of research content, my thesis can be divided into two parts. Part one examines local interactions and spillover effects between small regional governments using spatial econometric methods. The second part focuses on patterns within municipalities and inspects which institutions of citizen participation, elections and local petitions, influence local housing policies.
After Action Reports
(2017)
Age of Empires 3
(2017)
Age-related decline in executive functions and postural control due to degenerative processes in the central nervous system have been related to increased fall-risk in old age. Many studies have shown cognitive-postural dual-task interference in old adults, but research on the role of specific executive functions in this context has just begun. In this study, we addressed the question whether postural control is impaired depending on the coordination of concurrent response-selection processes related to the compatibility of input and output modality mappings as compared to impairments related to working-memory load in the comparison of cognitive dual and single tasks. Specifically, we measured total center of pressure (CoP) displacements in healthy female participants aged 19–30 and 66–84 years while they performed different versions of a spatial one-back working memory task during semi-tandem stance on an unstable surface (i.e., balance pad) while standing on a force plate. The specific working-memory tasks comprised: (i) modality compatible single tasks (i.e., visual-manual or auditory-vocal tasks), (ii) modality compatible dual tasks (i.e., visual-manual and auditory-vocal tasks), (iii) modality incompatible single tasks (i.e., visual-vocal or auditory-manual tasks), and (iv) modality incompatible dual tasks (i.e., visual-vocal and auditory-manual tasks). In addition, participants performed the same tasks while sitting. As expected from previous research, old adults showed generally impaired performance under high working-memory load (i.e., dual vs. single one-back task). In addition, modality compatibility affected one-back performance in dual-task but not in single-task conditions with strikingly pronounced impairments in old adults. Notably, the modality incompatible dual task also resulted in a selective increase in total CoP displacements compared to the modality compatible dual task in the old but not in the young participants. These results suggest that in addition to effects of working-memory load, processes related to simultaneously overcoming special linkages between input- and output modalities interfere with postural control in old but not in young female adults. Our preliminary data provide further evidence for the involvement of cognitive control processes in postural tasks.
Alexander von Humboldt war in Polen bereits im ausgehenden 18. Jahrhundert berühmt geworden. Er reiste mehrmals nach Polen und unterhielt Kontakte zu polnischen oder polnischstämmigen Wissenschaftlern. Aus den 30er und 40er Jahren stammen die meisten schriftlichen Belege, die von Beziehungen Humboldts zu solchen Persönlichkeiten wie Ludwik Zejszner, Józef Waraszkiewicz oder Filip Neryusz Walter zeugen. Nicht nachweisbar ist heute dafür Humboldts Kontakt zu Wincenty Pol sowie zu Ignacy Domeyko. Humboldt inspiriert nicht nur polnische Wissenschaftler, sondern auch führende polnische Dichter der Romantik. Viele polnische Exilanten verdanken dem deutschen Gelehrten wertvolle Kontakte, Empfehlungsschreiben und Gesuche bei damaligen Machthabern.
Das von Alexander von Humboldt ab 1804 oder später verfasste Manuskript „Isle de Cube. Antilles en général“ wurde erst kürzlich zum ersten Mal veröffentlicht. Es stellt die Grundlage für den Essai politique sur l‘île de Cuba (1826) dar, der als das „wichtigste liberale Manifest des 19. Jahrhunderts gegen die Sklaverei“ gilt. Ziel der Untersuchung ist, die textgenetische inhaltliche und stilistische Entwicklung vom Manuskript zur Publikation ansatzweise nachverfolgen zu können, um Rückschlüsse auf Humboldts Arbeitsweise und Strategien als Autor mit einem politischen Anliegen zu ziehen.
The all-female Amazon molly (Poecilia formosa) is the result of a hybridization of the Atlantic molly (P. mexicana) and the sailfin molly (P. latipinna) approximately 120,000 years ago. As a gynogenetic species, P. formosa needs to copulate with heterospecific males including males from one of its bisexual ancestral species. However, the sperm only triggers embryogenesis of the diploid eggs. The genetic information of the sperm donor typically will not contribute to the next generation of P. formosa. Hence, P. formosa possesses generally one allele from each of its ancestral species at any genetic locus. This raises the question whether both ancestral alleles are equally expressed in P. formosa. Allele-specific expression (ASE) has been previously assessed in various organisms, e.g., human and fish, and ASE was found to be important in the context of phenotypic variability and disease. In this study, we utilized Real-Time PCR techniques to estimate ASE of the androgen receptor alpha (arα) gene in several distinct tissues of Amazon mollies. We found an allelic bias favoring the maternal ancestor (P. mexicana) allele in ovarian tissue. This allelic bias was not observed in the gill or the brain tissue. Sequencing of the promoter regions of both alleles revealed an association between an Indel in a known CpG island and differential expression. Future studies may reveal whether our observed cis-regulatory divergence is caused by an ovary-specific trans-regulatory element, preferentially activating the allele of the maternal ancestor.
Alles auf (Studien)anfang!
(2017)
This study combines spaceborne multitemporal and hyperspectral data to analyze the spatial distribution of surface evaporite minerals and changes in a semi-arid depositional environment associated with episodic flooding events, the Omongwa salt pan (Kalahari, Namibia). The dynamic of the surface crust is evaluated by a change-detection approach using the Iterative-reweighted Multivariate Alteration Detection (IR-MAD) based on the Landsat archive imagery from 1984 to 2015. The results show that the salt pan is a highly dynamic and heterogeneous landform. A change gradient is observed from very stable pan border to a highly dynamic central pan. On the basis of hyperspectral EO-1 Hyperion images, the current distribution of surface evaporite minerals is characterized using Spectral Mixture Analysis (SMA). Assessment of field and image endmembers revealed that the pan surface can be categorized into three major crust types based on diagnostic absorption features and mineralogical ground truth data. The mineralogical crust types are related to different zones of surface change as well as pan morphology that influences brine flow during the pan inundation and desiccation cycles. These combined information are used to spatially map depositional environments where the more dynamic halite crust concentrates in lower areas although stable gypsum and calcite/sepiolite crusts appear in higher elevated areas.
The central aim of this thesis is to demonstrate the benefits of innovative frequency-based methods to better explain the variability observed in lake ecosystems. Freshwater ecosystems may be the most threatened part of the hydrosphere. Lake ecosystems are particularly sensitive to changes in climate and land use because they integrate disturbances across their entire catchment. This makes understanding the dynamics of lake ecosystems an intriguing and important research priority. This thesis adds new findings to the baseline knowledge regarding variability in lake ecosystems. It provides a literature-based, data-driven and methodological framework for the investigation of variability and patterns in environmental parameters in the time frequency domain.
Observational data often show considerable variability in the environmental parameters of lake ecosystems. This variability is mostly driven by a plethora of periodic and stochastic processes inside and outside the ecosystems. These run in parallel and may operate at vastly different time scales, ranging from seconds to decades. In measured data, all of these signals are superimposed, and dominant processes may obscure the signals of other processes, particularly when analyzing mean values over long time scales. Dominant signals are often caused by phenomena at long time scales like seasonal cycles, and most of these are well understood in the limnological literature. The variability injected by biological, chemical and physical processes operating at smaller time scales is less well understood. However, variability affects the state and health of lake ecosystems at all time scales. Besides measuring time series at sufficiently high temporal resolution, the investigation of the full spectrum of variability requires innovative methods of analysis.
Analyzing observational data in the time frequency domain allows to identify variability at different time scales and facilitates their attribution to specific processes. The merit of this approach is subsequently demonstrated in three case studies. The first study uses a conceptual analysis to demonstrate the importance of time scales for the detection of ecosystem responses to climate change. These responses often occur during critical time windows in the year, may exhibit a time lag and can be driven by the exceedance of thresholds in their drivers. This can only be detected if the temporal resolution of the data is high enough. The second study applies Fast Fourier Transform spectral analysis to two decades of daily water temperature measurements to show how temporal and spatial scales of water temperature variability can serve as an indicator for mixing in a shallow, polymictic lake. The final study uses wavelet coherence as a diagnostic tool for limnology on a multivariate high-frequency data set recorded between the onset of ice cover and a cyanobacteria summer bloom in the year 2009 in a polymictic lake. Synchronicities among limnological and meteorological time series in narrow frequency bands were used to identify and disentangle prevailing limnological processes.
Beyond the novel empirical findings reported in the three case studies, this thesis aims to more generally be of interest to researchers dealing with now increasingly available time series data at high temporal resolution. A set of innovative methods to attribute patterns to processes, their drivers and constraints is provided to help make more efficient use of this kind of data.
This dissertation explores whether the processing of ellipsis is affected by changes in the complexity of the antecedent, either due to added linguistic material or to the presence of a temporary ambiguity. Murphy (1985) hypothesized that ellipsis is resolved via a string copying procedure when the antecedent is within the same sentence, and that copying longer strings takes more time. Such an account also implies that the antecedent is copied without its structure, which in turn implies that recomputing its syntax and semantics may be necessary at the ellipsis gap. Alternatively, several accounts predict null effects of antecedent complexity, as well as no reparsing. These either involve a structure copying mechanism that is cost-free and whose finishing time is thus independent of the form of the antecedent (Frazier & Clifton, 2001), treat ellipsis as a pointer into content-addressable memory with direct access (Martin & McElree, 2008, 2009), or assume that one structure is ‘shared’ between antecedent and gap (Frazier & Clifton, 2005).
In a self-paced reading study on German sluicing, temporarily ambiguous garden-path clauses were used as antecedents, but no evidence of reparsing in the form of a slowdown at the ellipsis site was found. Instead, results suggest that antecedents which had been reanalyzed from an initially incorrect structure were easier to retrieve at the gap. This finding that can be explained within the framework of cue-based retrieval parsing (Lewis & Vasishth, 2005), where additional syntactic operations on a structure yield memory reactivation effects.
Two further self-paced reading studies on German bare argument ellipsis and English verb phrase ellipsis investigated if adding linguistic content to the antecedent would increase processing times for the ellipsis, and whether insufficiently demanding comprehension tasks may have been responsible for earlier null results (Frazier & Clifton, 2000; Martin & McElree, 2008). It has also been suggested that increased antecedent complexity should shorten rather than lengthen retrieval times by providing more unique memory features (Hofmeister, 2011). Both experiments failed to yield reliable evidence that antecedent complexity affects ellipsis processing times in either direction, irrespectively of task demands.
Finally, two eye-tracking studies probed more deeply into the proposed reactivation-induced speedup found in the first experiment. The first study used three different kinds of French garden-path sentences as antecedents, with two of them failing to yield evidence for reactivation. Moreover, the third sentence type showed evidence suggesting that having failed to assign a structure to the antecedent leads to a slowdown at the ellipsis site, as well as regressions towards the ambiguous part of the sentence. The second eye-tracking study used the same materials as the initial self-paced reading study on German, with results showing a pattern similar to the one originally observed, with some notable differences.
Overall, the experimental results are compatible with the view that adding linguistic material to the antecedent has no or very little effect on the ease with which ellipsis is resolved, which is consistent with the predictions of cost-free copying, pointer-based approaches and structure sharing. Additionally, effects of the antecedent’s parsing history on ellipsis processing may be due to reactivation, the availability of multiple representations in memory, or complete failure to retrieve a matching target.
Background: Malaria is an old life-threatening parasitic disease that is still affecting many people, mainly children living in sub-Saharan Africa. Availability of effective antimalarial drugs played a significant role in the treatment and control of malaria. However, recent information on the emergence of P. falciparum parasites resistant to one of the artemisinin-based combination therapies suggests the need for discovery of new drug molecules. Therefore, this study aimed to evaluate the antiplasmodial activity of extracts, fractions and isolated compound from medicinal plants traditionally used in the treatment of malaria in Tanzania.
Methods: Dry powdered plant materials were extracted by cold macerations using different solvents. Norcaesalpin D was isolated by column chromatography from dichloromethane root extract of Caesalpinia bonducella and its structure was assigned based on the spectral data. Crude extracts, fractions and isolated compound were evaluated for antiplasmodial activity against chloroquine-sensitive P. falciparum (3D7), chloroquine-resistant P. falciparum (Dd2, K1) and artemisinin-resistant P. falciparum (IPC 5202 Battambang, IPC 4912 Mondolkiri) strains using the parasite lactate dehydrogenase assay.
Results: The results indicated that extracts of Erythrina schliebenii, Holarrhena pubescens, Dissotis melleri and C. bonducella exhibited antiplasmodial activity against Dd2 parasites. Ethanolic root extract of E. schliebenii had an IC50 of 1.87 mu g/mL while methanolic and ethanolic root extracts of H. pubescens exhibited an IC50 = 2.05 mu g/mL and IC50 = 2.43 mu g/mL, respectively. Fractions from H. pubescens and C. bonducella roots were found to be highly active against K1, Dd2 and artemisinin-resistant parasites. Norcaesalpin D from C. bonducella root extract was active with IC50 of 0.98, 1.85 and 2.13 mu g/mL against 3D7, Dd2 and IPC 4912-Mondolkiri parasites, respectively.
Conclusions: Antiplasmodial activity of norcaesalpin D and extracts of E. schliebenii, H. pubescens, D. melleri and C. bonducella reported in this study requires further attention for the discovery of antimalarial lead compounds for future drug development.
Researchers have made many approaches to study the complexities of the mammalian taste system; however molecular mechanisms of taste processing in the early structures of the central taste pathway remain unclear. More recently the Arc catFISH (cellular compartment analysis of temporal activity by fluorescent in situ hybridisation) method has been used in our lab to study neural activation following taste stimulation in the first central structure in the taste pathway, the nucleus of the solitary tract. This method uses the immediate early gene Arc as a neural activity marker to identify taste-responsive neurons. Arc plays a critical role in memory formation and is necessary for conditioned taste aversion memory formation. In the nucleus of the solitary tract only bitter taste stimulation resulted in increased Arc expression, however this did not occur following stimulation with tastants of any other taste quality. The primary target for gustatory NTS neurons is the parabrachial nucleus (PbN) and, like Arc, the PbN plays an important role in conditioned taste aversion learning.
The aim of this thesis is to investigate Arc expression in the PbN following taste stimulation to elucidate the molecular identity and function of Arc expressing, taste- responsive neurons. Naïve and taste-conditioned mice were stimulated with tastants from each of the five basic taste qualities (sweet, salty, sour, umami, and bitter), with additional bitter compounds included for comparison. The expression patterns of Arc and marker genes were analysed using in situ hybridisation (ISH). The Arc catFISH method was used to observe taste-responsive neurons following each taste stimulation. A double fluorescent in situ hybridisation protocol was then established to investigate possible neuropeptide genes involved in neural responses to taste stimulation.
The results showed that bitter taste stimulation induces increased Arc expression in the PbN in naïve mice. This was not true for other taste qualities. In mice conditioned to find an umami tastant aversive, subsequent umami taste stimulation resulted in an increase in Arc expression similar to that seen in bitter-stimulated mice. Taste-responsive Arc expression was denser in the lateral PbN than the medial PbN. In mice that received two temporally separated taste stimulations, each stimulation time-point showed a distinct population of Arc-expressing neurons, with only a small population (10 – 18 %) of neurons responding to both stimulations. This suggests that either each stimulation event activates a different population of neurons, or that Arc is marking something other than simple cellular activation, such as long-term cellular changes that do not occur twice within a 25 minute time frame. Investigation using the newly established double-FISH protocol revealed that, of the bitter-responsive Arc expressing neuron population: 16 % co-expressed calcitonin RNA; 17 % co-expressed glucagon-like peptide 1 receptor RNA; 17 % co-expressed hypocretin receptor 1 RNA; 9 % co-expressed gastrin-releasing peptide RNA; and 20 % co-expressed neurotensin RNA. This co-expression with multiple different neuropeptides suggests that bitter-activated Arc expression mediates multiple neural responses to the taste event, such as taste aversion learning, suppression of food intake, increased heart rate, and involves multiple brain structures such as the lateral hypothalamus, amygdala, bed nucleus of the stria terminalis, and the thalamus.
The increase in Arc-expression suggests that bitter taste stimulation, and umami taste stimulation in umami-averse animals, may result in an enhanced state of Arc- dependent synaptic plasticity in the PbN, allowing animals to form taste-relevant memories to these aversive compounds more readily. The results investigating neuropeptide RNA co- expression suggest the amygdala, bed nucleus of the stria terminalis, and thalamus as possible targets for bitter-responsive Arc-expressing PbN neurons.
Bobrowski hatte nach dem Abitur die Absicht geäußert, Kunstgeschichte zu studieren, doch Krieg und Kriegsgefangenschaft vereitelten seinen Plan: Der Wehrmachtsangehörige wurde einzig im Winter 1941/1942 für ein Studiensemester an der Universität Berlin vom Kriegsdienst freigestellt. Nachhaltig beeindruckt war Bobrowski insbesondere von der Vorlesung „Deutsche Kunst der Goethezeit“ des Lehrstuhlinhabers Wilhelm Pinder. Trotz eines grundlegenden Einflusses ist indessen zu keinem Zeitpunkt Pinders ideologischer Hintergrund in Bobrowskis Gedichten manifest geworden. Nach der Rückkehr aus sowjetischer Gefangenschaft an Weihnachten 1949 war für den mittlerweile Zweiunddreißigjährigen an ein Studium nicht mehr zu denken. Die lebenslange intermediale Auseinandersetzung mit Werken der bildenden Kunst in seinem Œuvre kann indessen als Ausdruck seiner vielfältigen kulturgeschichtlichen Interessen und Neigungen interpretiert werden. Die Lebensphasen des Dichters korrelieren mit einer motivischen Entwicklung seiner Bildgedichte: Insbesondere half ihm die unantastbare Ästhetik bedeutender Kunstwerke, das Grauen der letzten Kriegsjahre und die Entbehrungen in sowjetischer Kriegsgefangenschaft zu überwinden. Didaktisch-moralische Zielsetzungen prägten zunächst die in den Jahren nach seiner Heimkehr entstandenen Gedichte, bevor sich Bobrowski inhaltlich und formal von diesem Gedichttypus zu lösen vermochte und vermehrt Gedichte zu schreiben begann, die kulturgeschichtliche Dimensionen annahmen und historische, mythologische, biblische und religionsphilosophische Themen in epochenübergreifende Zusammenhänge stellten. Die Gedichte über die Künstler Jawlensky und Calder berühren gleichzeitig kulturlandschaftliche Aspekte. Im letzten Lebensjahrzehnt interessierte sich Bobrowski zunehmend für die Kunst des 20. Jahrhunderts, während die moderne Architektur aus seinem Werk ausgeklammert blieb.
Architektur bildet eine Leitmotivik in Bobrowskis lyrischem Werk. Die übertragene Bedeutungsebene der in den Gedichten benannten sakralen und profanen Einzelbauten, aber auch der städtischen und dörflichen Ensembles sowie einzelner Gebäudeteile, verändert sich mehrfach im Laufe der Jahre. Ausgehend von traditionellen, paargereimten Jugendgedichten in jambischem Versmaß, in denen architektonische Elemente Teil einer Wahrnehmung bilden, die alles Außerästhetische ausblendet, wandelt sich der Sinngehalt der Sakral- und Profanbauten in Bobrowskis lyrischem Werk ein erstes Mal während den Kriegsjahren in Russland, die der Wehrmachtsangehörige am Ilmensee verbracht hat. In den damals entstandenen Oden zeugen die architektonischen Relikte von Leid, Tod und Zerstörung. Noch fehlt indessen der später so zentrale Gedanke der Schuld, der erst im Rückblick auf jene Zeit in den Gedichten, die nach der Rückkehr aus der Kriegsgefangenschaft bis zu Bobrowskis frühem Tod entstanden sind, thematisiert worden ist.
Gegen Ende des Kriegs und in den Jahren der Kriegsgefangenschaft besinnt sich Bobrowski erneut auf Heimatthemen, und die Architektur in seinen Gedichten wird zu einem ästhetisch überhöhten Fluchtpunkt seiner Sehnsucht nach Ostpreußen und dem Memelgebiet. In Kriegsgefangenschaft tritt erstmals der Aspekt des Sublimen in seinen Gedichten auf, und zwar sowohl bezogen auf die Malerei als auch auf die Architektur. Dieser Gedanke wird einerseits nach der Rückkehr nach Berlin in den Gedichten über die Architektur gotischer Kathedralen und das bauliche Erbe des Klassizismus weitergesponnen, doch steht in den damals entstandenen Gedichten das Kulturerbe Europas auch für historisches Unrecht und eine schwere, weit zurückreichende Schuld.
Von dieser auf den ganzen Kontinent bezogenen Kritik wendet sich Bobrowski in den nachfolgenden Jahren ab und konzentriert sich auf die Schuld der Deutschen gegenüber den Völkern Osteuropas. Damit erhält auch die Architektur in seinen Gedichten eine neue Bedeutung. Die Relikte der Ritterburgen des deutschen Ordens zeugen von der Herrschaft der mittelalterlichen Eroberer und verschmelzen dabei mit der Natur: Das Zeichenhafte der Architektur wird Teil der Landschaft. Im letzten Lebensjahrzehnt entstehen vermehrt Gedichte, die sich auf Parkanlagen und städtische Grünräume beziehen.
Der Dichter hat sich nicht nur auf persönliche Erfahrungen, sondern mitunter auch auf Bildquellen abstützt, ohne dass er das Original je gesehen hätte. Nur schwer zugänglich sind die Gedichte über Chagall und Gauguin ohne die Erkenntnis, dass sie sich auf Bildvorlagen in schmalen, populärwissenschaftlichen Büchern beziehen, die Bobrowski jeweils kurz vor der Niederschrift der entsprechenden Gedichte erworben hat. Anders verhält es sich mit jenen russischen Kirchen, die Eingang in sein lyrisches Werk gefunden haben. Bobrowski hat sie alle selbst im Krieg gesehen, und die meisten scheinen noch heute zu bestehen und können mit einiger Sicherheit identifiziert werden, wozu auch die Briefe des Dichters aus jener Zeit beitragen.
Background
In isometric muscle function, there are subjectively two different modes of performance: one can either hold isometrically – thus resist an impacting force – or push isometrically – therefore work against a stable resistance. The purpose of this study is to investigate whether or not two different isometric muscle actions – the holding vs. pushing one (HIMA vs PIMA) – can be distinguished by objective parameters.
Methods
Ten subjects performed two different measuring modes at 80% of MVC realized by a special pneumatic system. During HIMA the subject had to resist the defined impacting force of the pneumatic system in an isometric position, whereby the force of the cylinder works in direction of elbow flexion against the subject. During PIMA the subject worked isometrically in direction of elbow extension against a stable position of the system. The signals of pressure, force, acceleration and mechanomyography/-tendography (MMG/MTG) of the elbow extensor (MMGtri/MTGtri) and the abdominal muscle (MMGobl) were recorded and evaluated concerning the duration of maintaining the force level (force endurance) and the characteristics of MMG-/MTG-signals. Statistical group differences comparing HIMA vs. PIMA were estimated using SPSS.
Results
Significant differences between HIMA and PIMA were especially apparent regarding the force endurance: During HIMA the subjects showed a decisively shorter time of stable isometric position (19 ± 8 s) in comparison with PIMA (41 ± 24 s; p = .005). In addition, during PIMA the longest isometric plateau amounted to 59.4% of the overall duration time of isometric measuring, during HIMA it lasted 31.6% (p = .000). The frequency of MMG/MTG did not show significant differences. The power in the frequency ranges of 8–15 Hz and 10–29 Hz was significantly higher in the MTGtri performing HIMA compared to PIMA (but not for the MMGs). The amplitude of MMG/MTG did not show any significant difference considering the whole measurement. However, looking only at the last 10% of duration time (exhaustion), the MMGtri showed significantly higher amplitudes during PIMA.
Conclusion
The results suggest that under holding isometric conditions muscles exhaust earlier. That means that there are probably two forms of isometric muscle action. We hypothesize two potential reasons for faster yielding during HIMA: (1) earlier metabolic fatigue of the muscle fibers and (2) the complexity of neural control strategies.
The purpose of the project was to develop the Discounting Inventory (DI), a measure of individual differences in delay, probability, effort, and social discounting, all related to behavioral impulsivity. Over 400 items relating to four types of discounting were generated. Next, a study followed by a series of psychometric analyses of data obtained from a group of 2843 individuals was conducted. Principal Component Analysis yielded a four-factor structure of data, reflecting the four types of discounting. The results of Confirmatory Factor Analysis showed good fit of the four-factor model to data. Through several iterations of retaining and deleting items on the basis of their component loadings, item intercorrelations, and contribution to coefficient alphas, the total number of items was reduced to 48. The final 48-item version of the inventory has satisfactory psychometric characteristics, including Cronbach’s alpha and test–retest stability. In addition, significant correlations were observed between the DI and traditional discounting instruments, suggesting that the DI measures a construct similar to the behavioral discounting process. The development of the tool was based on the assumption that discounting is a personality trait. However, the present data suggest that discounting may reflect more a state than trait function.
Natural hazards can have serious societal and economic impacts. Worldwide, around one third of economic losses due to natural hazards are attributable to floods. The majority of natural hazards are triggered by weather-related extremes such as heavy precipitation, rapid snow melt, or extreme temperatures. Some of them, and in particular floods, are expected to further increase in terms of frequency and/or intensity in the coming decades due to the impacts of climate change. In this context, the European Alps areas are constantly disclosed as being particularly sensitive.
In order to enhance the resilience of societies to natural hazards, risk assessments are substantial as they can deliver comprehensive risk information to be used as a basis for effective and sustainable decision-making in natural hazards management. So far, current assessment approaches mostly focus on single societal or economic sectors – e.g. flood damage models largely concentrate on private-sector housing – and other important sectors, such as the transport infrastructure sector, are widely neglected. However, transport infrastructure considerably contributes to economic and societal welfare, e.g. by ensuring mobility of people and goods. In Austria, for example, the national railway network is essential for the European transit of passengers and freights as well as for the development of the complex Alpine topography. Moreover, a number of recent experiences show that railway infrastructure and transportation is highly vulnerable to natural hazards. As a consequence, the Austrian Federal Railways had to cope with economic losses on the scale of several million euros as a result of flooding and other alpine hazards.
The motivation of this thesis is to contribute to filling the gap of knowledge about damage to railway infrastructure caused by natural hazards by providing new risk information for actors and stakeholders involved in the risk management of railway transportation. Hence, in order to support the decision-making towards a more effective and sustainable risk management, the following two shortcomings in natural risks research are approached: i) the lack of dedicated models to estimate flood damage to railway infrastructure, and ii) the scarcity of insights into possible climate change impacts on the frequency of extreme weather events with focus on future implications for railway transportation in Austria.
With regard to flood impacts to railway infrastructure, the empirically derived damage model Railway Infrastructure Loss (RAIL) proved expedient to reliably estimate both structural flood damage at exposed track sections of the Northern Railway and resulting repair cost. The results show that the RAIL model is capable of identifying flood risk hot spots along the railway network and, thus, facilitates the targeted planning and implementation of (technical) risk reduction measures. However, the findings of this study also show that the development and validation of flood damage models for railway infrastructure is generally constrained by the continuing lack of detailed event and damage data.
In order to provide flood risk information on the large scale to support strategic flood risk management, the RAIL model was applied for the Austrian Mur River catchment using three different hydraulic scenarios as input as well as considering an increased risk aversion of the railway operator. Results indicate that the model is able to deliver comprehensive risk information also on the catchment level. It is furthermore demonstrated that the aspect of risk aversion can have marked influence on flood damage estimates for the study area and, hence, should be considered with regard to the development of risk management strategies.
Looking at the results of the investigation on future frequencies of extreme weather events jeopardizing railway infrastructure and transportation in Austria, it appears that an increase in intense rainfall events and heat waves has to be expected, whereas heavy snowfall and cold days are likely to decrease. Furthermore, results indicate that frequencies of extremes are rather sensitive to changes of the underlying thresholds. It thus emphasizes the importance to carefully define, validate, and — if needed — to adapt the thresholds that are used to detect and forecast meteorological extremes. For this, continuous and standardized documentation of damaging events and near-misses is a prerequisite.
Overall, the findings of the research presented in this thesis agree on the necessity to improve event and damage documentation procedures in order to enable the acquisition of comprehensive and reliable risk information via risk assessments and, thus, support strategic natural hazards management of railway infrastructure and transportation.
Ecosystem services (ESs) are defined as the contributions that ecosystems make to human wellbeing and are increasingly being used as an approach to explore the importance of ecosystems for humans through their valuation. Although value plurality has been recognised long before the mainstreaming of ESs research, socio-cultural valuation is still underrepresented in ESs assessments. It is the central goal of this PhD dissertation to explore the ability of socio-cultural valuation methods for the operationalisation of ESs research in land management. To address this, I formulated three research objectives that are briefly outlined below and relate to the three studies conducted during this dissertation.
The first objective relates to the assessment of the current role of socio-cultural valuation in ESs research. Human values are central to ESs research yet non-monetary socio-cultural valuation methods have been found underrepresented in the field of ESs science. In regard to the unbalanced consideration of value domains and conceptual uncertainties, I perform a systematic literature review aiming to answer the research question: To what extent have socio-cultural values been addressed in ESs assessments.
The second objective aims to test socio-cultural valuation methods of ESs and their relevance for land use preferences by exploring their methodological opportunities and limitations. Socio-cultural valuation methods have only recently become a focus in ESs research and therefore bear various uncertainties in regard to their methodological implications. To overcome these uncertainties, I analysed responses to a visitor survey. The research questions related to the second objective were: What are the implications of different valuation methods for ESs values? To what extent are land use preferences explained by socio-cultural values of ESs?
The third objective addressed in this dissertation is the implementation of ESs research into land management through socio-cultural valuation. Though it is emphasised that the ESs approach can assist decision making, there is little empirical evidence of the effect of ESs knowledge on land management. I proposed a way to implement transdisciplinary, spatially explicit research on ESs by answering the following research questions: Which landscape features underpinning ESs supply are considered in land management? How can participatory approaches accounting for ESs be operationalised in land management?
The empirical research resulted in five main findings that provide answers to the research questions. First, this dissertation provides evidence that socio-cultural values are an integral part of ESs research. I found that they can be assessed for provisioning, regulating, and cultural services though they are linked to cultural services to a greater degree. Socio-cultural values have been assessed by monetary and non-monetary methods and their assessment is effectively facilitated by stakeholder participation. Second, I found that different methods of socio-cultural valuation revealed different information. Whereas rating revealed a general value of ESs, weighting was found more suitable to identify priorities across ESs. Value intentions likewise differed in the distribution of values, generally implying a higher value for others than for respondents themselves. Third, I showed that ESs values were distributed similarly across groups with differing land use preferences. Thus, I provided empirical evidence that ESs values and landscape values should not be used interchangeably. Fourth, I showed which landscape features important for ESs supply in a Scottish regional park are not sufficiently accounted for in the current management strategy. This knowledge is useful for the identification of priority sites for land management. Finally, I provide an approach to explore how ESs knowledge elicited by participatory mapping can be operationalised in land management. I demonstrate how stakeholder knowledge and values can be used for the identification of ESs hotspots and how these hotspots can be compared to current management priorities.
This dissertation helps to bridge current gaps of ESs science by advancing the understanding of the current role of socio-cultural values in ESs research, testing different methods and their relevance for land use preferences, and implementing ESs knowledge into land management. If and to what extent ESs and their values are implemented into ecosystem management is mainly the choice of the management. An advanced understanding of socio-cultural valuation methods contributes to the normative basis of this management, while the proposal for the implementation of ESs in land management presents a practical approach of how to transfer this type of knowledge into practice. The proposed methods for socio-cultural valuation can support guiding land management towards a balanced consideration of ESs and conservation goals.
The information about climate change impact on river discharge is vitally important for planning adaptation measures. The future changes can affect different water-related sectors. The main goal of this study was to investigate the potential water resource changes in Ukraine, focusing on three mesoscale river catchments (Teteriv, UpperWestern Bug, and Samara) characteristic for different geographical zones. The catchment scale watershed model—Soil and Water Integrated Model (SWIM)—was setup, calibrated, and validated for the three catchments under consideration. A set of seven GCM-RCM (General Circulation Model-Regional Climate Model) coupled climate scenarios corresponding to RCPs (Representative Concentration Pathways) 4.5 and 8.5 were used to drive the hydrological catchment model. The climate projections, used in the study, were considered as three combinations of low, intermediate, and high end scenarios. Our results indicate the shifts in the seasonal distribution of runoff in all three catchments. The spring high flow occurs earlier as a result of temperature increases and earlier snowmelt. The fairly robust trend is an increase in river discharge in the winter season, and most of the scenarios show a potential decrease in river discharge in the spring.
Assimilation of pseudo-tree-ring-width observations into an atmospheric general circulation model
(2017)
Paleoclimate data assimilation (DA) is a promising technique to systematically combine the information from climate model simulations and proxy records. Here, we investigate the assimilation of tree-ring-width (TRW) chronologies into an atmospheric global climate model using ensemble Kalman filter (EnKF) techniques and a process-based tree-growth forward model as an observation operator. Our results, within a perfect-model experiment setting, indicate that the "online DA" approach did not outperform the "off-line" one, despite its considerable additional implementation complexity. On the other hand, it was observed that the nonlinear response of tree growth to surface temperature and soil moisture does deteriorate the operation of the time-averaged EnKF methodology. Moreover, for the first time we show that this skill loss appears significantly sensitive to the structure of the growth rate function, used to represent the principle of limiting factors (PLF) within the forward model. In general, our experiments showed that the error reduction achieved by assimilating pseudo-TRW chronologies is modulated by the magnitude of the yearly internal variability in themodel. This result might help the dendrochronology community to optimize their sampling efforts.
The general purpose of this systematic review was to summarize, structure and evaluate the findings on automatic evaluations of exercising. Studies were eligible for inclusion if they reported measuring automatic evaluations of exercising with an implicit measure and assessed some kind of exercise variable. Fourteen nonexperimental and six experimental studies (out of a total N = 1,928) were identified and rated by two independent reviewers. The main study characteristics were extracted and the grade of evidence for each study evaluated. First, results revealed a large heterogeneity in the applied measures to assess automatic evaluations of exercising and the exercise variables. Generally, small to large-sized significant relations between automatic evaluations of exercising and exercise variables were identified in the vast majority of studies. The review offers a systematization of the various examined exercise variables and prompts to differentiate more carefully between actually observed exercise behavior (proximal exercise indicator) and associated physiological or psychological variables (distal exercise indicator). Second, a lack of transparent reported reflections on the differing theoretical basis leading to the use of specific implicit measures was observed. Implicit measures should be applied purposefully, taking into consideration the individual advantages or disadvantages of the measures. Third, 12 studies were rated as providing first-grade evidence (lowest grade of evidence), five represent second-grade and three were rated as third-grade evidence. There is a dramatic lack of experimental studies, which are essential for illustrating the cause-effect relation between automatic evaluations of exercising and exercise and investigating under which conditions automatic evaluations of exercising influence behavior. Conclusions about the necessity of exercise interventions targeted at the alteration of automatic evaluations of exercising should therefore not be drawn too hastily.
The aim of this thesis is to develop approaches to automatically recognise the structure of argumentation in short monological texts. This amounts to identifying the central claim of the text, supporting premises, possible objections, and counter-objections to these objections, and connecting them correspondingly to a structure that adequately describes the argumentation presented in the text.
The first step towards such an automatic analysis of the structure of argumentation is to know how to represent it. We systematically review the literature on theories of discourse, as well as on theories of the structure of argumentation against a set of requirements and desiderata, and identify the theory of J. B. Freeman (1991, 2011) as a suitable candidate to represent argumentation structure. Based on this, a scheme is derived that is able to represent complex argumentative structures and can cope with various segmentation issues typically occurring in authentic text.
In order to empirically test our scheme for reliability of annotation, we conduct several annotation experiments, the most important of which assesses the agreement in reconstructing argumentation structure. The results show that expert annotators produce very reliable annotations, while the results of non-expert annotators highly depend on their training in and commitment to the task.
We then introduce the 'microtext' corpus, a collection of short argumentative texts. We report on the creation, translation, and annotation of it and provide a variety of statistics. It is the first parallel corpus (with a German and English version) annotated with argumentation structure, and -- thanks to the work of our colleagues -- also the first annotated according to multiple theories of (global) discourse structure.
The corpus is then used to develop and evaluate approaches to automatically predict argumentation structures in a series of six studies: The first two of them focus on learning local models for different aspects of argumentation structure. In the third study, we develop the main approach proposed in this thesis for predicting globally optimal argumentation structures: the 'evidence graph' model. This model is then systematically compared to other approaches in the fourth study, and achieves state-of-the-art results on the microtext corpus. The remaining two studies aim to demonstrate the versatility and elegance of the proposed approach by predicting argumentation structures of different granularity from text, and finally by using it to translate rhetorical structure representations into argumentation structures.
The correctness of model transformations is a crucial element for model-driven engineering of high quality software. In particular, behavior preservation is the most important correctness property avoiding the introduction of semantic errors during the model-driven engineering process. Behavior preservation verification techniques either show that specific properties are preserved, or more generally and complex, they show some kind of behavioral equivalence or refinement between source and target model of the transformation. Both kinds of behavior preservation verification goals have been presented with automatic tool support for the instance level, i.e. for a given source and target model specified by the model transformation. However, up until now there is no automatic verification approach available at the transformation level, i.e. for all source and target models specified by the model transformation.
In this report, we extend our results presented in [27] and outline a new sophisticated approach for the automatic verification of behavior preservation captured by bisimulation resp. simulation for model transformations specified by triple graph grammars and semantic definitions given by graph transformation rules. In particular, we show that the behavior preservation problem can be reduced to invariant checking for graph transformation and that the resulting checking problem can be addressed by our own invariant checker even for a complex example where a sequence chart is transformed into communicating automata. We further discuss today's limitations of invariant checking for graph transformation and motivate further lines of future work in this direction.
Background
Non-typhoid Salmonella Typhimurium (S. Typhimurium) accounts for a high number of registered salmonellosis cases, and O-serotyping is one important tool for monitoring epidemiology and spread of the disease. Moreover, variations in glucosylated O-antigens are related to immunogenicity and spread in the host. However, classical autoagglutination tests combined with the analysis of specific genetic markers cannot always reliably register phase variable glucose modifications expressed on Salmonella O-antigens and additional tools to monitor O-antigen glucosylation phenotypes of S. Typhimurium would be desirable.
Results
We developed a test for the phase variable O-antigen glucosylation state of S. Typhimurium using the tailspike proteins (TSP) of Salmonella phages 9NA and P22. We used this ELISA like tailspike adsorption (ELITA) assay to analyze a library of 44 Salmonella strains. ELITA was successful in discriminating strains that carried glucose 1-6 linked to the galactose of O-polysaccharide backbone (serotype O1) from non-glucosylated strains. This was shown by O-antigen compositional analyses of the respective strains with mass spectrometry and capillary electrophoresis. The ELITA test worked rapidly in a microtiter plate format and was highly O-antigen specific. Moreover, TSP as probes could also detect glucosylated strains in flow cytometry and distinguish multiphasic cultures differing in their glucosylation state.
Conclusions
Tailspike proteins contain large binding sites with precisely defined specificities and are therefore promising tools to be included in serotyping procedures as rapid serotyping agents in addition to antibodies. In this study, 9NA and P22TSP as probes could specifically distinguish glucosylation phenotypes of Salmonella on microtiter plate assays and in flow cytometry. This opens the possibility for flow sorting of cell populations for subsequent genetic analyses or for monitoring phase variations during large scale O-antigen preparations necessary for vaccine production.
Postpartale Depressionen sind häufige und schwerwiegende psychische Erkrankungen mit ungünstigem Einfluss auf die kindliche Entwicklung. Als Haupttransmissionsweg gilt die frühe Mutter-Kind-Interaktion. Über die langfristigen Auswirkungen auf die Kinder im Erwachsenenalter und die Rolle der Interaktion liegen kaum Ergebnisse vor. Im Rahmen der Mannheimer Risikokinderstudie wurden postpartale Depressionen bis zwei Jahre nach der Geburt erfasst. Die kindliche Entwicklung wurde fortlaufend und die Mutter-Kind-Interaktion im Alter von 3 Monaten standardisiert erhoben. 28 Kinder postpartal depressiver und 107 Kinder gesunder Mütter konnten mit 25 Jahren untersucht werden. Beeinträchtigungen der kognitiven und psychischen Entwicklung bei Kindern postpartal depressiver Mütter waren bis ins Erwachsenenalter nachweisbar. Responsives bzw. sensitives mütterliches Verhalten wirkte der negativen Entwicklung entgegen. Dies betont die Bedeutung einer hohen Qualität der Mutter-Kind-Interaktion für die Entwicklung von Risikokindern.
Dieser Band knüpft an die repräsentative Dokumentation des Fortbildungsprojektes Belcantare Brandenburg. Jedes Kind kann singen! für musikunterrichtende Grundschullehrkräfte im Land Brandenburg und seine begleitendende Evaluationsforschung an. Inhaltlicher Schwerpunkt dieses Bandes ist die Vorstellung der explorativen Evaluationsstudie mit ihren sensiblen Konzepten, Fragenstellungen, ihrem triangulierenden Forschungsdesign und ausgewählten Forschungsergebnissen aus den Staffeln 1 und 2.
Die fachdidaktischen, musikpsychologischen und methodischen Kontexte der Evaluationsforschung werden durch Fachartikel entsprechender Autoren in diesem Band transparent und bereichern ihn im besonderen Maße. Die Mitwirkung von Studierenden am Forschungsprozess erforderte Anwendungsleitfäden zur methodischen Handhabung verschiedener Erhebungsinstrumente und Auswertungsmethoden zu entwickeln, denen hier der Raum zur Veröffentlichung gegeben wurde.
Besonderung und Immanenz
(2017)
Zentrales Anliegen dieser Arbeit ist ein historisch-systematisches Verständnis der Philosophischen Anthropologie Helmuth Plessners im Zusammenhang mit zentralen theoretischen Entwicklungen der klassischen deutschen Philosophie. Im philosophischen Problemrahmen von Besonderung und Immanenz werden verschiedene historische Modelle untersucht. Die Arbeit geht von der Philosophie Immanuel Kants und Georg Friedrich Wilhelm Hegels aus und konzentriert sich auf das für die klassisch-deutsche Philosophie und ihre Überwindung der traditionellen Metaphysik entscheidende Methodenprinzip der Grenzbestimmung. Die Untersuchung beginnt im Kapitel Ausgangspunkt mit Kants Definition der Grenzbestimmung in der Kritik der reinen Vernunft als transzendental-philosophische Grundoperation und damit mit den Begriffen Grenze, Schranke und Zweckmäßigkeit. Anschließend wird Hegels grundlegende Antwort auf Kants Problem in der Dialektik der Grenze untersucht: In der Wissenschaft der Logik, der Logik des Seins, entwickelt Hegel ein erweitertes Konzept von Besonderung gegen Kant. Im Kern kritisiert Hegel Kants Begriff der Grenze im Sinne einer abstrakten Schranke, die einem begrifflich entwickelten Ansatz der Grenze als Funktionsbestimmung und damit der sich aus der Methode der Dialektik ergebenden Anforderung transzendentaler Individuation widerspricht. Die systematische zentrale Bedeutung der Dialektik der Grenze wird in der Begriffslogik im Abschnitt Teleologie weiter untersucht, da Grenze hier besonders mit dem Problem der Immanenz bzw. Vermittlung verknüpft ist. Im Gegensatz zu Kant entwickelt Hegel die Idee der Vermittlung begrifflich über den Begriff der Zweckmäßigkeit, beantwortet sie aber in der Wissenschaft der Logik innerhalb eines geschlossenen Modells. An diese Ergebnisse anschließend wird die Transformation des philosophischen Problemrahmens von Besonderung und Immanenz in der von Plessner im frühen 20. Jahrhundert gegründeten Philosophischen Anthropologie untersucht. Plessner greift in seinem Hauptwerk Die Stufen des Organischen und der Mensch auf diesen Rahmen quasi-transzendental zu und begründet eine moderne Natur- und Kulturphilosophie in einer performativ-philosophischen Wendung neu. Auf diese Weise kann Plessner Hegels geschlossenes philosophisches Modell von Besonderung und Immanenz aufbrechen und einen nicht-dualistischen dritten Weg moderner Philosophie jenseits von Neukantianismus und Existenzialismus vorzeichnen.
Between-school variation in students' achievement, motivation, affect, and learning strategies
(2017)
To plan group-randomized trials where treatment conditions are assigned to schools, researchers need design parameters that provide information about between-school differences in outcomes as well as the amount of variance that can be explained by covariates at the student (L1) and school (L2) levels. Most previous research has offered these parameters for U.S. samples and for achievement as the outcome. This paper and the online supplementary materials provide design parameters for 81 countries in three broad outcome categories (achievement, affect and motivation, and learning strategies) for domain-general and domain-specific (mathematics, reading, and science) measures. Sociodemographic characteristics were used as covariates. Data from representative samples of 15-year-old students stemmed from five cycles of the Programme for International Student Assessment (PISA; total number of students/schools: 1,905,147/70,098). Between-school differences as well as the amount of variance explained at L1 and L2 varied widely across countries and educational outcomes, demonstrating the limited generalizability of design parameters across these dimensions. The use of the design parameters to plan group-randomized trials is illustrated.
Beworbene Vergangenheit
(2017)
Novel nanogels that possess the capacity to change their physico-chemical properties in response to external stimuli are promising drug-delivery candidates for the treatment of severe skin diseases. As thermoresponsive nanogels (tNGs) are capable of enhancing penetration through biological barriers such as the stratum corneum and are taken up by keratinocytes of human skin, potential adverse consequences of their exposure must be elucidated. In this study, tNGs were synthesized from dendritic polyglycerol (dPG) and two thermoresponsive polymers. tNG_dPG_tPG are the combination of dPG with poly(glycidyl methyl ether-co-ethyl glycidyl ether) (p(GME-co-EGE)) and tNG_dPG_pNIPAM the one with poly(N-isopropylacrylamide) (pNIPAM). Both thermoresponsive nanogels are able to incorporate high amounts of dexamethasone and tacrolimus, drugs used in the treatment of severe skin diseases. Cellular uptake, intracellular localization and the toxicological properties of the tNGs were comprehensively characterized in primary normal human keratinocytes (NHK) and in spontaneously transformed aneuploid immortal keratinocyte cell line from adult human skin (HaCaT). Laser scanning confocal microscopy revealed fluorescently labeled tNGs entered into the cells and localized predominantly within lysosomal compartments. MTT assay, comet assay and carboxy-H2DCFDA assay, demonstrated neither cytotoxic or genotoxic effects, nor any induction of reactive oxygen species of the tNGs in keratinocytes. In addition, both tNGs were devoid of eye irritation potential as shown by bovine corneal opacity and permeability (BCOP) test and red blood cell (RBC) hemolysis assay. Therefore, our study provides evidence that tNGs are locally well tolerated and underlines their potential for cutaneous drug delivery.
In light of possible future restrictions on the use of fossil fuel, due to climate change obligations and continuous depletion of global fossil fuel reserves, the search for alternative renewable energy sources is expected to be an issue of great concern for policy stakeholders. This study assessed the feasibility of bioenergy production under relatively low-intensity conservative, eco-agricultural settings (as opposed to those produced under high-intensity, fossil fuel based industrialized agriculture). Estimates of the net energy gain (NEG) and the energy return on energy invested (EROEI) obtained from a life cycle inventory of the energy inputs and outputs involved reveal that the energy efficiency of bioenergy produced in low-intensity eco-agricultural systems could be as much as much as 448.5–488.3 GJ·ha−1 of NEG and an EROEI of 5.4–5.9 for maize ethanol production systems, and as much as 155.0–283.9 GJ·ha−1 of NEG and an EROEI of 14.7–22.4 for maize biogas production systems. This is substantially higher than for industrialized agriculture with a NEG of 2.8–52.5 GJ·ha−1 and an EROEI of 1.2–1.7 for maize ethanol production systems, as well as a NEG of 59.3–188.7 GJ·ha−1 and an EROEI of 2.2–10.2 for maize biogas production systems. Bioenergy produced in low-intensity eco-agricultural systems could therefore be an important source of energy with immense net benefits for local and regional end-users, provided a more efficient use of the co-products is ensured.
The large variety of atmospheric circulation systems affecting the eastern Asian climate is reflected by the complex Asian vegetation distribution. Particularly in the transition zones of these circulation systems, vegetation is supposed to be very sensitive to climate change. Since proxy records are scarce, hitherto a mechanistic understanding of the past spatio-temporal climate-vegetation relationship is lacking. To assess the Holocene vegetation change and to obtain an ensemble of potential mid-Holocene biome distributions for eastern Asia, we forced the diagnostic biome model BIOME4 with climate anomalies of different transient Holocene climate simulations performed in coupled atmosphere-ocean(-vegetation) models. The simulated biome changes are compared with pollen-based biome records for different key regions.
In all simulations, substantial biome shifts during the last 6000 years are confined to the high northern latitudes and the monsoon-westerly wind transition zone, but the temporal evolution and amplitude of change strongly depend on the climate forcing. Large parts of the southern tundra are replaced by taiga during the mid-Holocene due to a warmer growing season and the boreal treeline in northern Asia is shifted northward by approx. 4 degrees in the ensemble mean, ranging from 1.5 to 6 degrees in the individual simulations, respectively. This simulated treeline shift is in agreement with pollen-based reconstructions from northern Siberia. The desert fraction in the transition zone is reduced by 21% during the mid-Holocene compared to pre-industrial due to enhanced precipitation. The desert-steppe margin is shifted westward by 5 degrees (1-9 degrees in the individual simulations). The forest biomes are expanded north-westward by 2 degrees, ranging from 0 to 4 degrees in the single simulations. These results corroborate pollen-based reconstructions indicating an extended forest area in north-central China during the mid-Holocene. According to the model, the forest-to-non-forest and steppe-to-desert changes in the climate transition zones are spatially not uniform and not linear since the mid-Holocene.
Materials based on biodegradable polyesters, such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT), have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein, the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate is reported. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue engineering.
Research in legal decision making has demonstrated the tendency to blame the victim and exonerate the perpetrator of sexual assault. This study examined the hypothesis of a special leniency bias in rape cases by comparing them to cases of robbery. N = 288 participants received descriptions of rape and robbery of a female victim by a male perpetrator and made ratings of victim and perpetrator blame. Case scenarios varied with respect to the prior relationship (strangers, acquaintances, ex-partners) and coercive strategy (force vs. exploiting victim intoxication). More blame was attributed to the victim and less blame was attributed to the perpetrator for rape than for robbery. Information about a prior relationship between victim and perpetrator increased ratings of victim blame and decreased perceptions of perpetrator blame in the rape cases, but not in the robbery cases. The findings support the notion of a special leniency bias in sexual assault cases.
Borehole instabilities are frequently encountered when drilling through finely laminated, organic rich shales (Økland and Cook, 1998; Ottesen, 2010; etc.); such instabilities should be avoided to assure a successful exploitation and safe production of the contained unconventional hydrocarbons. Borehole instabilities, such as borehole breakouts or drilling induced tensile fractures, may lead to poor cementing of the borehole annulus, difficulties with recording and interpretation of geophysical logs, low directional control and in the worst case the loss of the well. If these problems are not recognized and expertly remedied, pollution of the groundwater or the emission of gases into the atmosphere can occur since the migration paths of the hydrocarbons in the subsurface are not yet fully understood (e.g., Davies et al., 2014; Zoback et al., 2010). In addition, it is often mentioned that the drilling problems encountered and the resulting downtimes of the wellbore system in finely laminated shales significantly increase drilling costs (Fjaer et al., 2008; Aadnoy and Ong, 2003).
In order to understand and reduce the borehole instabilities during drilling in unconventional shales, we investigate stress-induced irregular extensions of the borehole diameter, which are also referred to as borehole breakouts. For this purpose, experiments with different borehole diameters, bedding plane angles and stress boundary conditions were performed on finely laminated Posidonia shales. The Lower Jurassic Posidonia shale is one of the most productive source rocks for conventional reservoirs in Europe and has the greatest potential for unconventional oil and gas in Europe (Littke et al., 2011).
In this work, Posidonia shale specimens from the North (PN) and South (PS) German basins were selected and characterized petrophysically and mechanically. The composition of the two shales is dominated by calcite (47-56%) followed by clays (23-28%) and quartz (16-17%). The remaining components are mainly pyrite and organic matter. The porosity of the shales varies considerably and is up to 10% for PS and 1% for PN, which is due to a larger deposition depth of PN. Both shales show marked elasticity and strength anisotropy, which can be attributed to a macroscopic distribution and orientation of soft and hard minerals. Under load the hard minerals form a load-bearing, supporting structure, while the soft minerals compensate the deformation. Therefore, if loaded parallel to the bedding, the Posidonia shale is more brittle than loaded normal to the bedding. The resulting elastic anisotropy, which can be defined by the ratio of the modulus of elasticity parallel and normal to the bedding, is about 50%, while the strength anisotropy (i.e., the ratio of uniaxial compressive strength normal and parallel to the bedding) is up to 66%. Based on the petrophysical characterization of the two rocks, a transverse isotropy (TVI) was derived. In general, PS is softer and weaker than PN, which is due to the stronger compaction of the material due to the higher burial depth.
Conventional triaxial borehole breakout experiments on specimens with different borehole diameters showed that, when the diameter of the borehole is increased, the stress required to initiate borehole breakout decreases to a constant value. This value can be expressed as the ratio of the tangential stress and the uniaxial compressive strength of the rock. The ratio increases exponentially with decreasing borehole diameter from about 2.5 for a 10 mm diameter hole to ~ 7 for a 1 mm borehole (increase of initiation stress by 280%) and can be described by a fracture mechanic based criterion. The reduction in borehole diameter is therefore a considerable aspect in reducing the risk of breakouts. New drilling techniques with significantly reduced borehole diameters, such as "fish-bone" holes, are already underway and are currently being tested (e.g., Xing et al., 2012).
The observed strength anisotropy and the TVI material behavior are also reflected in the observed breakout processes at the borehole wall. Drill holes normal to the bedding develop breakouts in a plane of isotropy and are not affected by the strength or elasticity anisotropy. The observed breakouts are point-symmetric and form compressive shear failure planes, which can be predicted by a Mohr-Coulomb failure approach. If the shear failure planes intersect, conjugate breakouts can be described as "dog-eared” breakouts.
While the initiation of breakouts for wells oriented normal to the stratification has been triggered by random local defects, reduced strengths parallel to bedding planes are the starting point for breakouts for wells parallel to the bedding. In the case of a deflected borehole trajectory, therefore, the observed failure type changes from shear-induced failure surfaces to buckling failure of individual layer packages. In addition, the breakout depths and widths increased, resulting in a stress-induced enlargement of the borehole cross-section and an increased output of rock material into the borehole. With the transition from shear to buckling failure and changing bedding plane angle with respect to the borehole axis, the stress required for inducing wellbore breakouts drops by 65%.
These observations under conventional triaxial stress boundary conditions could also be confirmed under true triaxial stress conditions. Here breakouts grew into the rock as a result of buckling failure, too. In this process, the broken layer packs rotate into the pressure-free drill hole and detach themselves from the surrounding rock by tensile cracking. The final breakout shape in Posidonia shale can be described as trapezoidal when the bedding planes are parallel to the greatest horizontal stress and to the borehole axis. In the event that the largest horizontal stress is normal to the stratification, breakouts were formed entirely by shear fractures between the stratification and required higher stresses to initiate similar to breakouts in conventional triaxial experiments with boreholes oriented normal to the bedding.
In the content of this work, a fracture mechanics-based failure criterion for conventional triaxial loading conditions in isotropic rocks (Dresen et al., 2010) has been successfully extended to true triaxial loading conditions in the transverse isotropic rock to predict the initiation of borehole breakouts. The criterion was successfully verified on the experiments carried out.
The extended failure criterion and the conclusions from the laboratory and numerical work may help to reduce the risk of borehole breakouts in unconventional shales.
Background: Rodents of the genus Rattus are among the most pervasive and successful invasive species, causing major vicissitudes in native ecological communities. A broad and flexible generalist diet has been suggested as key to the invasion success of Rattus spp. Here, we use an indirect approach to better understand foraging niche width, plasticity, and overlap within and between introduced Rattus spp. in anthropogenic habitats and natural humid forests of Madagascar.
Results: Based on stable carbon and nitrogen isotope values measured in hair samples of 589 individual rodents, we found that Rattus rattus had an extremely wide foraging niche, encompassing the isotopic space covered by a complete endemic forest-dwelling Malagasy small mammal community. Comparisons of Bayesian standard ellipses, as well as (multivariate) mixed-modeling analyses, revealed that the stable isotope niche of R. rattus tended to change seasonally and differed between natural forests and anthropogenic habitats, indicating plasticity in feeding niches. In co-occurrence, R. rattus and Rattus norvegicus partitioned feeding niches. Isotopic mismatch of signatures of individual R. rattus and the habitat in which they were captured, indicate frequent dispersal movements for this species between natural forest and anthropogenic habitats.
Conclusions: Since R. rattus are known to transmit a number of zoonoses, potentially affecting communities of endemic small mammals, as well as humans, these movements presumably increase transmission potential. Our results suggest that due to their generalist diet and potential movement between natural forest and anthropogenic habitats, Rattus spp. might affect native forest-dependent Malagasy rodents as competitors, predators, and disease vectors. The combination of these effects helps explain the invasion success of Rattus spp. and the detrimental effects of this genus on the endemic Malagasy rodent fauna.
Bumps in river profiles
(2017)
The analysis of longitudinal river profiles is an important tool for studying landscape evolution. However, characterizing river profiles based on digital elevation models (DEMs) suffers from errors and artifacts that particularly prevail along valley bottoms. The aim of this study is to characterize uncertainties that arise from the analysis of river profiles derived from different, near-globally available DEMs. We devised new algorithms quantile carving and the CRS algorithm - that rely on quantile regression to enable hydrological correction and the uncertainty quantification of river profiles. We find that globally available DEMs commonly overestimate river elevations in steep topography. The distributions of elevation errors become increasingly wider and right skewed if adjacent hillslope gradients are steep. Our analysis indicates that the AW3D DEM has the highest precision and lowest bias for the analysis of river profiles in mountainous topography. The new 12m resolution TanDEM-X DEM has a very low precision, most likely due to the combined effect of steep valley walls and the presence of water surfaces in valley bottoms. Compared to the conventional approaches of carving and filling, we find that our new approach is able to reduce the elevation bias and errors in longitudinal river profiles.
Bürgerpartizipation
(2017)
Mosses are a major component of the arctic vegetation, particularly in wetlands. We present C / N atomic ratio, delta C-13 and delta N-15 data of 400 brown-moss samples belonging to 10 species that were collected along hydrological gradients within polygonal mires located on the southern Taymyr Peninsula and the Lena River delta in northern Siberia. Additionally, n-alkane patterns of six of these species (16 samples) were investigated. The aim of the study is to see whether the inter-and intraspecific differences in C / N, isotopic compositions and n-alkanes are indicative of habitat, particularly with respect to water level. Overall, we find high variability in all investigated parameters for two different moisture-related groups of moss species. The C / N ratios range between 11 and 53 (median: 32) and show large variations at the intraspecific level. However, species preferring a dry habitat (xero-mesophilic mosses) show higher C / N ratios than those preferring a wet habitat (meso-hygrophilic mosses). The delta C-13 values range between 37.0 and 22.5% (median D 27.8 %). The delta N-15 values range between 6.6 and C 1.7%(median D 2.2 %). We find differences in delta C-13 and delta N-15 compositions between both habitat types. For some species of the meso-hygrophilic group, we suggest that a relationship between the individ-ual habitat water level and isotopic composition can be inferred as a function of microbial symbiosis. The n-alkane distribution also shows differences primarily between xeromesophilic and meso-hygrophilic mosses, i. e. having a dominance of n-alkanes with long (n-C29, n-C31 /and intermediate (n-C25 /chain lengths, respectively. Overall, our results reveal that C / N ratios, isotopic signals and n-alkanes of studied brown-moss taxa from polygonal wetlands are characteristic of their habitat.
The current study was undertaken to investigate the relation between serum C-reactive protein (CRP) concentrations and parameters of renal function in dogs with naturally occurring renal disease. Dogs were assigned to groups according to plasma creatinine concentration, urinary protein-to-creatinine ratio (UP/UC), and exogenous plasma creatinine clearance (P-Cl(Cr)) rates. Group A (healthy control dogs; n = 8): non-azotemic (plasma creatinine <125 mu mol/l) and nonproteinuric (UP/UC <0.2), with P-Cl(Cr) rates >90 ml/min/m(2); group B (n = 11): non-azotemic, nonproteinuric dogs with reduced P-Cl(Cr) rates (50-89 ml/min/m(2)); group C (n = 7): azotemic, borderline proteinuric dogs (P-Cl(Cr) rates: 22-67 ml/min/m(2)); and group D (n = 6): uremic, proteinuric dogs (not tested for P-Cl(Cr)). The serum CRP concentrations were measured via commercial enzyme-linked immunosorbent assay. The CRP concentrations in the clinically healthy dogs (group A) ranged from 2.09 mg/l to 8.60 mg/l (median: 3.21 mg/l). In comparison with dogs of group A, median CRP concentrations were significantly (P < 0.01) elevated in dogs of group B (17.6 mg/l, range: 17.0-19.2 mg/l), group C (24.8 mg/l, range: 18.0-32.5 mg/l), and group D (59.7 mg/l, range: 17.7-123 mg/l). Serum CRP was significantly related to P-Cl(Cr) (r = -0.83; P < 0.001), plasma creatinine (r = 0.81; P < 0.001), UP/UC (r = 0.70; P < 0.001), and leukocytes (r = 0.49; P < 0.01). The significant relations between serum CRP concentrations and biochemical parameters of kidney function in plasma and urine suggest that a stimulation of the acute phase response is implicated in the pathogenesis of canine renal disease.
Water infiltration in soil is not only affected by the inherent heterogeneities of soil, but even more by the interaction with plant roots and their water uptake. Neutron tomography is a unique non-invasive 3D tool to visualize plant root systems together with the soil water distribution in situ. So far, acquisition times in the range of hours have been the major limitation for imaging 3D water dynamics. Implementing an alternative acquisition procedure we boosted the speed of acquisition capturing an entire tomogram within 10 s. This allows, for the first time, tracking of a water front ascending in a rooted soil column upon infiltration of deuterated water time-resolved in 3D. Image quality and resolution could be sustained to a level allowing for capturing the root system in high detail. Good signal-to-noise ratio and contrast were the key to visualize dynamic changes in water content and to localize the root uptake. We demonstrated the ability of ultra-fast tomography to quantitatively image quick changes of water content in the rhizosphere and outlined the value of such imaging data for 3D water uptake modelling. The presented method paves the way for time-resolved studies of various 3D flow and transport phenomena in porous systems
Mathematical models of bacterial growth have been successfully applied to study the relationship between antibiotic drug exposure and the antibacterial effect. Since these models typically lack a representation of cellular processes and cell physiology, the mechanistic integration of drug action is not possible on the cellular level. The cellular mechanisms of drug action, however, are particularly relevant for the prediction, analysis and understanding of interactions between antibiotics. Interactions are also studied experimentally, however, a lacking consent on the experimental protocol hinders direct comparison of results. As a consequence, contradictory classifications as additive, synergistic or antagonistic are reported in literature.
In the present thesis we developed a novel mathematical model for bacterial growth that integrates cell-level processes into the population growth level. The scope of the model is to predict bacterial growth under antimicrobial perturbation by multiple antibiotics in vitro.
To this end, we combined cell-level data from literature with population growth data for Bacillus subtilis, Escherichia coli and Staphylococcus aureus. The cell-level data described growth-determining characteristics of a reference cell, including the ribosomal concentration and efficiency. The population growth data comprised extensive time-kill curves for clinically relevant antibiotics (tetracycline, chloramphenicol, vancomycin, meropenem, linezolid, including dual combinations).
The new cell-level approach allowed for the first time to simultaneously describe single and combined effects of the aforementioned antibiotics for different experimental protocols, in particular different growth phases (lag and exponential phase). Consideration of ribosomal dynamics and persisting sub-populations explained the decreased potency of linezolid on cultures in the lag phase compared to exponential phase cultures. The model captured growth rate dependent killing and auto-inhibition of meropenem and - also for vancomycin exposure - regrowth of the bacterial cultures due to adaptive resistance development. Stochastic interaction surface analysis demonstrated the pronounced antagonism between meropenem and linezolid to be robust against variation in the growth phase and pharmacodynamic endpoint definition, but sensitive to a change in the experimental duration.
Furthermore, the developed approach included a detailed representation of the bacterial cell-cycle. We used this representation to describe septation dynamics during the transition of a bacterial culture from the exponential to stationary growth phase. Resulting from a new mechanistic understanding of transition processes, we explained the lag time between the increase in cell number and bacterial biomass during the transition from the lag to exponential growth phase. Furthermore, our model reproduces the increased intracellular RNA mass fraction during long term exposure of bacteria to chloramphenicol.
In summary, we contribute a new approach to disentangle the impact of drug effects, assay readout and experimental protocol on antibiotic interactions. In the absence of a consensus on the corresponding experimental protocols, this disentanglement is key to translate information between heterogeneous experiments and also ultimately to the clinical setting.
The connection between the macroscopic description of collective chaos and the underlying microscopic dynamics is thoroughly analysed in mean-field models of one-dimensional oscillators. We investigate to what extent infinitesimal perturbations of the microscopic configurations can provide information also on the stability of the corresponding macroscopic phase. In ensembles of identical one-dimensional dynamical units, it is possible to represent the microscopic configurations so as to make transparent their connection with the macroscopic world. As a result, we find evidence of an intermediate, mesoscopic, range of distances, over which the instability is neither controlled by the microscopic equations nor by the macroscopic ones. We examine a whole series of indicators, ranging from the usual microscopic Lyapunov exponents, to the collective ones, including finite-amplitude exponents. A system of pulse-coupled oscillators is also briefly reviewed as an example of non-identical phase oscillators where collective chaos spontaneously emerges.
In this work the human AOX1 was characterized and detailed aspects regarding the expression, the enzyme kinetics and the production of reactive oxygen species (ROS) were investigated. The hAOX1 is a cytosolic enzyme belonging to the molybdenum hydroxylase family. Its catalytically active form is a homodimer with a molecular weight of 300 kDa. Each monomer (150 kDa) consists of three domains: a N-terminal domain (20 kDa) containing two [2Fe-2S] clusters, a 40 kDa intermediate domain containing a flavin adenine dinucleotide (FAD), and a C-terminal domain (85 kDa) containing the substrate binding pocket and the molybdenum cofactor (Moco). The hAOX1 has an emerging role in the metabolism and pharmacokinetics of many drugs, especially aldehydes and N- heterocyclic compounds.
In this study, the hAOX1 was hetereogously expressed in E. coli TP1000 cells, using a new codon optimized gene sequence which improved the expressed protein yield of around 10-fold compared to the previous expression systems for this enzyme. To increase the catalytic activity of hAOX1, an in vitro chemical sulfuration was performed to favor the insertion of the equatorial sulfido ligand at the Moco with consequent increased enzymatic activity of around 10-fold. Steady-state kinetics and inhibition studies were performed using several substrates, electron acceptors and inhibitors. The recombinant hAOX1 showed higher catalytic activity when molecular oxygen was used as electron acceptor. The highest turn over values were obtained with phenanthridine as substrate. Inhibition studies using thioridazine (phenothiazine family), in combination with structural studies performed in the group of Prof. M.J. Romão, Nova Universidade de Lisboa, showed a new inhibition site located in proximity of the dimerization site of hAOX1. The inhibition mode of thioridazine resulted in a noncompetitive inhibition type. Further inhibition studies with loxapine, a thioridazine-related molecule, showed the same type of inhibition. Additional inhibition studies using DCPIP and raloxifene were carried out.
Extensive studies on the FAD active site of the hAOX1 were performed. Twenty new hAOX1 variants were produced and characterized. The hAOX1 variants generated in this work were divided in three groups: I) hAOX1 single nucleotide polymorphisms (SNP) variants; II) XOR- FAD loop hAOX1 variants; III) additional single point hAOX1 variants. The hAOX1 SNP variants G46E, G50D, G346R, R433P, A439E, K1231N showed clear alterations in their catalytic activity, indicating a crucial role of these residues into the FAD active site and in relation to the overall reactivity of hAOX1.
Furthermore, residues of the bovine XOR FAD flexible loop (Q423ASRREDDIAK433) were introduced in the hAOX1. FAD loop hAOX1 variants were produced and characterized for their stability and catalytic activity. Especially the variants hAOX1 N436D/A437D/L438I, N436D/A437D/L438I/I440K and Q434R/N436D/A437D/L438I/I440K showed decreased catalytic activity and stability. hAOX1 wild type and variants were tested for reactivity toward NADH but no reaction was observed.
Additionally, the hAOX1 wild type and variants were tested for the generation of reactive oxygen species (ROS). Interestingly, one of the SNP variants, hAOX1 L438V, showed a high ratio of superoxide prodction. This result showed a critical role for the residue Leu438 in the mechanism of oxygen radicals formation by hAOX1. Subsequently, further hAOX1 variants having the mutated Leu438 residue were produced. The variants hAOX1 L438A, L438F and L438K showed superoxide overproduction of around 85%, 65% and 35% of the total reducing equivalent obtained from the substrate oxidation.
The results of this work show for the first time a characterization of the FAD active site of the hAOX1, revealing the importance of specific residues involved in the generation of ROS and effecting the overall enzymatic activity of hAOX1. The hAOX1 SNP variants presented here indicate that those allelic variations in humans might cause alterations ROS balancing and clearance of drugs in humans.
Im Sinne des Refinements von Tierversuchen sollen alle Bedingungen während der Zucht, der Haltung und des Transports von zu Versuchszwecken gehaltenen Tieren und alle Methoden während des Versuchs so verbessert werden, dass die verwendeten Tiere ein minimales Maß an potentiellem Distress, Schmerzen oder Leiden erfahren. Zudem soll ihr Wohlbefinden durch die Möglichkeit des Auslebens speziesspezifischer Verhaltensweisen und die Anwendung tierschonender Verfahren maximal gefördert werden. Zur Etablierung von Grundsätzen des Refinements sind grundlegende Kenntnisse über die physiologischen Bedürfnisse und Verhaltensansprüche der jeweiligen Spezies unabdingbar. Die Experimentatoren sollten das Normalverhalten der Tiere kennen, um potentielle Verhaltensabweichungen, wie Stereotypien, zu verstehen und interpretieren zu können. Standardisierte Haltungsbedingungen von zu Versuchszwecken gehaltenen Mäusen weichen in diversen Aspekten von der natürlichen Umgebung ab und erfordern eine gewisse Adaptation. Ist ein Tier über einen längeren Zeitraum unfähig, sich an die gegebenen Umstände anzupassen, können abnormale Verhaltensweisen, wie Stereotypien auftreten. Stereotypien werden definiert als Abweichungen vom Normalverhalten, die repetitiv und ohne Abweichungen im Ablauf ausgeführt werden, scheinbar keiner Funktion dienen und der konkreten Umweltsituation nicht immer entsprechen.
Bisher war unklar, in welchem Ausmaß stereotypes Verhalten den metabolischen Phänotyp eines Individuums beeinflusst. Ziel dieser Arbeit war es daher, das stereotype Verhalten der FVB/NJ-Maus erstmals detailliert zu charakterisieren, systematisch zusammenzutragen, welche metabolischen Konsequenzen dieses Verhalten bedingt und wie sich diese auf das Wohlbefinden der Tiere und die Verwendung stereotyper Tiere in Studien mit tierexperimentellem Schwerpunkt auswirken.
Der Versuch begann mit der Charakterisierung der mütterlichen Fürsorge in der Parentalgeneration. Insgesamt wurden 35 Jungtiere der F1-Generation vom Absatz an, über einen Zeitraum von 11 Wochen einzeln gehalten, kontinuierlich beobachtet, bis zum Versuchsende wöchentlich Kotproben gesammelt und das Körpergewicht bestimmt. Zusätzlich erfolgten begleitende Untersuchungen wie Verhaltenstests und die Erfassung der physischen Aktivität und metabolischer Parameter. Anschließend wurden u.a. die zerebralen Serotonin- und Dopamingehalte, fäkale Glucocorticoidlevels, hepatisches Glykogen und muskuläre Glykogen- und Triglyceridlevels bestimmt.
Nahezu unabhängig von der mütterlichen Herkunft entwickelte sich bei mehr als der Hälfte der 35 Jungtiere in der F1-Generation stereotypes Verhalten. Diese Daten deuten darauf hin, dass es keine Anzeichen für das Erlernen oder eine direkte genetische Transmission stereotypen Verhaltens bei der FVB/NJ-Maus gibt. Über den gesamten Beobachtungszeitraum zeichneten sich die stereotypen FVB/NJ-Mäuse durch ein eingeschränktes Verhaltensrepertoire aus. Zu Gunsten der erhöhten Aktivität und des Ausübens stereotypen Verhaltens lebten sie insgesamt weniger andere Verhaltensweisen (Klettern, Graben, Nagen) aus. Darüber hinaus waren Stereotypien sowohl im 24-Stunden Open Field Test als auch in der Messeinrichtung der indirekten Tierkalorimetrie mit einer erhöhten Aktivität und Motilität assoziiert, während die circadiane Rhythmik nicht divergierte. Diese erhöhte körperliche Betätigung spiegelte sich in den niedrigeren Körpergewichtsentwicklungen der stereotypen Tiere wieder. Außerdem unterschieden sich die Körperfett- und Körpermuskelanteile.
Zusammenfassend lässt sich sagen, dass das Ausüben stereotypen Verhaltens zu Differenzen im metabolischen Phänotyp nicht-stereotyper und stereotyper FVB/NJ-Mäuse führt. Im Sinne der „Guten Wissenschaftlichen Praxis“ sollte das zentrale Ziel jedes Wissenschaftlers sein, aussagekräftige und reproduzierbare Daten hervorzubringen. Jedoch können keine validen Resultate von Tieren erzeugt werden, die in Aspekten variieren, die für den vorgesehenen Zweck der Studie nicht berücksichtigt wurden. Deshalb sollten nicht-stereotype und stereotype Individuen nicht innerhalb einer Versuchsgruppe randomisiert werden. Stereotype Tiere demzufolge von geplanten Studien auszuschließen, würde allerdings dem Gebot des zweiten R’s – der Reduction – widersprechen. Um Refinement zu garantieren, sollte der Fokus auf der maximal erreichbaren Prävention stereotypen Verhaltens liegen. Diverse Studien haben bereits gezeigt, dass die Anreicherung der Haltungsumwelt (environmental enrichment) zu einer Senkung der Prävalenz von Stereotypien bei Mäusen führt, dennoch kommen sie weiterhin vor. Daher sollte environmental enrichment zukünftig weniger ein „Kann“, sondern ein „Muss“ sein – oder vielmehr: der Goldstandard. Zudem würde eine profunde phänotypische Charakterisierung dazu beitragen, Mausstämme zu erkennen, die zu Stereotypien neigen und den für den spezifischen Zweck am besten geeigneten Mausstamm zu identifizieren, bevor ein Experiment geplant wird.
Tremendous progress in the development of thin film solar cell techniques has been made over the last decade. The field of organic solar cells is constantly developing, new material classes like Perowskite solar cells are emerging and different types of hybrid organic/inorganic material combinations are being investigated for their physical properties and their applicability in thin film electronics. Besides typical single-junction architectures for solar cells, multi-junction concepts are also being investigated as they enable the overcoming of theoretical limitations of a single-junction. In multi-junction devices each sub-cell operates in different wavelength regimes and should exhibit optimized band-gap energies. It is exactly this tunability of the band-gap energy that renders organic solar cell materials interesting candidates for multi-junction applications. Nevertheless, only few attempts have been made to combine inorganic and organic solar cells in series connected multi-junction architectures. Even though a great diversity of organic solar cells exists nowadays, their open circuit voltage is usually low compared to the band-gap of the active layer. Hence, organic low band-gap solar cells in particular show low open circuit voltages and the key factors that determine the voltage losses are not yet fully understood. Besides open circuit voltage losses the recombination of charges in organic solar cells is also a prevailing research topic, especially with respect to the influence of trap states.
The exploratory focus of this work is therefore set, on the one hand, on the development of hybrid organic/inorganic multi-junctions and, on the other hand, on gaining a deeper understanding of the open circuit voltage and the recombination processes of organic solar cells.
In the first part of this thesis, the development of a hybrid organic/inorganic triple-junction will be discussed which showed at that time (Jan. 2015) a record power conversion efficiency of 11.7%. The inorganic sub-cells of these devices consist of hydrogenated amorphous silicon and were delivered by the Competence Center Thin-Film and Nanotechnology for Photovoltaics in Berlin. Different recombination contacts and organic sub-cells were tested in conjunction with these inorganic sub-cells on the basis of optical modeling predictions for the optimal layer thicknesses to finally reach record efficiencies for this type of solar cells.
In the second part, organic model systems will be investigated to gain a better understanding of the fundamental loss mechanisms that limit the open circuit voltage of organic solar cells. First, bilayer systems with different orientation of the donor and acceptor molecules were investigated to study the influence of the donor/acceptor orientation on non-radiative voltage loss. Secondly, three different bulk heterojunction solar cells all comprising the same amount of fluorination and the same polymer backbone in the donor component were examined to study the influence of long range electrostatics on the open circuit voltage. Thirdly, the device performance of two bulk heterojunction solar cells was compared which consisted of the same donor polymer but used different fullerene acceptor molecules. By this means, the influence of changing the energetics of the acceptor component on the open circuit voltage was investigated and a full analysis of the charge carrier dynamics was presented to unravel the reasons for the worse performance of the solar cell with the higher open circuit voltage. In the third part, a new recombination model for organic solar cells will be introduced and its applicability shown for a typical low band-gap cell. This model sheds new light on the recombination process in organic solar cells in a broader context as it re-evaluates the recombination pathway of charge carriers in devices which show the presence of trap states. Thereby it addresses a current research topic and helps to resolve alleged discrepancies which can arise from the interpretation of data derived by different measurement techniques.
We present electrical impedance measurements of amoeboid cells on microelectrodes. The model organism Dictyostelium discoideum shows under starvation conditions a transition to collective behavior when chemotactic cells collect in multicellular aggregates. We show how impedance recordings give a precise picture of the stages of aggregation by tracing the dynamics of cell-substrate adhesion. Furthermore, we present for the first time systematic single cell measurements of wild type cells and four mutant strains that differ in their substrate adhesion strength. We recorded the projected cell area by time lapse microscopy and found a correlation between quasi-periodic oscillations in the kinetics of the projected area - the cell shape oscillation - and the long-term trend in the impedance signal. Typically, amoeboid motility advances via a cycle of membrane protrusion, substrate adhesion, traction of the cell body and tail retraction. This motility cycle results in the quasi-periodic oscillations of the projected cell area and the impedance. In all cell lines measured, similar periods were observed for this cycle, despite the differences in attachment strength. We observed that cell-substrate attachment strength strongly affects the impedance in that the deviations from mean (the magnitude of fluctuations) are enhanced in cells that effectively transmit forces, generated by the cytoskeleton, to the substrate. For example, in talA- cells, which lack the actin anchoring protein talin, the fluctuations are strongly reduced. Single cell force spectroscopy and results from a detachment assay, where adhesion is measured by exposing cells to shear stress, confirm that the magnitude of impedance fluctuations is a correct measure for the strength of substrate adhesion. Finally, we also worked on the integration of cell-substrate impedance sensors into microfluidic devices. A chip-based electrical chemotaxis assay is designed which measures the speed of chemotactic cells migrating over microelectrodes along a chemical concentration gradient.
Background: There is an increasing awareness of the impact of parental risk perception on the weight course of the child and the parent's readiness to engage in preventive efforts, but only less is known about factors related to the parental perception of the right time for the implementation of preventive activities. The aim of this study was to examine parental perceptions of the appropriate time to engage in child weight management strategies, and the factors associated with different weight points at which mothers recognize the need for preventive actions.
Methods: 352 mothers with children aged 2-10 years took part in the study. We assessed mothers' perceptions of the actual and preferred weight status of their child, their ability to identify overweight and knowledge of its associated health risks, as well as perceptions of the right time for action to prevent overweight in their child. A regression analysis was conducted to examine whether demographic and weight related factors as well as the maternal general risk perception were associated with recognizing the need to implement prevention strategies.
Results: Although most of the parents considered a BMI in the 75th to 90th percentile a valid reason to engage in the prevention of overweight, 19% of the mothers were not willing to engage in prevention until their child reached the 97th percentile. Whereas the child's sex and the identification of an elevated BMI were significant predictors for parents' recognition of the 75th percentile as right point to engage in prevention efforts, an inability to recognize physical health risks associated with overweight silhouettes emerged as a significant factor predicting which parents would delay prevention efforts until a child's BMI reached the 97th percentile.
Conclusion: Parental misperceptions of overweight and associated health risks constitute unfavorable conditions for preventive actions. Feedback on the health risks associated with overweight could help increase maternal readiness for change.
We consider synchronization properties of arrays of spin-torque nano-oscillators coupled via an RC load. We show that while the fully synchronized state of identical oscillators may be locally stable in some parameter range, this synchrony is not globally attracting. Instead, regimes of different levels of compositional complexity are observed. These include chimera states (a part of the array forms a cluster while other units are desynchronized), clustered chimeras (several clusters plus desynchronized oscillators), cluster state (all oscillators form several clusters), and partial synchronization (no clusters but a nonvanishing mean field). Dynamically, these states are also complex, demonstrating irregular and close to quasiperiodic modulation. Remarkably, when heterogeneity of spin-torque oscillators is taken into account, dynamical complexity even increases: close to the onset of a macroscopic mean field, the dynamics of this field is rather irregular.
In the wake of 21st century, humanity witnessed a phenomenal raise of urban agglomerations as powerhouses for innovation and socioeconomic growth. Driving much of national (and in few instances even global) economy, such a gargantuan raise of cities is also accompanied by subsequent increase in energy, resource consumption and waste generation. Much of anthropogenic transformation of Earth's environment in terms of environmental pollution at local level to planetary scale in the form of climate change is currently taking place in cities. Projected to be crucibles for entire humanity by the end of this century, the ultimate fate of humanity predominantly lies in the hands of technological innovation, urbanites' attitudes towards energy/resource consumption and development pathways undertaken by current and future cities. Considering the unparalleled energy, resource consumption and emissions currently attributed to global cities, this thesis addresses these issues from an efficiency point of view. More specifically, this thesis addresses the influence of population size, density, economic geography and technology in improving urban greenhouse gas (GHG) emission efficiency and identifies the factors leading to improved eco-efficiency in cities. In order to investigate the in uence of these factors in improving emission and resource efficiency in cities, a multitude of freely available datasets were coupled with some novel methodologies and analytical approaches in this thesis.
Merging the well-established Kaya Identity to the recently developed urban scaling laws, an Urban Kaya Relation is developed to identify whether large cities are more emission efficient and the intrinsic factors leading to such (in)efficiency. Applying Urban Kaya Relation to a global dataset of 61 cities in 12 countries, this thesis identifed that large cities in developed regions of the world will bring emission efficiency gains because of the better technologies implemented in these cities to produce and utilize energy consumption while the opposite is the case for cities in developing regions. Large cities in developing countries are less efficient mainly because of their affluence and lack of efficient technologies. Apart from the in uence of population size on emission efficiency, this thesis identified the crucial role played by population density in improving building and on-road transport sector related emission efficiency in cities. This is achieved by applying the City Clustering Algorithm (CCA) on two different gridded land use datasets and a standard emission inventory to attribute these sectoral emissions to all inhabited settlements in the USA. Results show that doubling the population density would entail a reduction in the total CO2 emissions in buildings and on-road sectors typically by at least 42 %. Irrespective of their population size and density, cities are often blamed for their intensive resource consumption that threatens not only local but also global sustainability. This thesis merged the concept of urban metabolism with benchmarking and identified cities which are eco-efficient. These cities enable better socioeconomic conditions while being less burden to the environment. Three environmental burden indicators (annual average NO2 concentration, per capita waste generation and water consumption) and two socioeconomic indicators (GDP per capita and employment ratio) for 88 most populous European cities are considered in this study. Using two different non-parametric ranking methods namely regression residual ranking and Data Envelopment Analysis (DEA), eco-efficient cities and their determining factors are identified. This in-depth analysis revealed that mature cities with well-established economic structures such as Munich, Stockholm and Oslo are eco-efficient. Further, correlations between objective eco-efficiency ranking with each of the indicator rankings and the ranking of urbanites' subjective perception about quality of life are analyzed. This analysis revealed that urbanites' perception about quality of life is not merely confined to the socioeconomic well-being but rather to their combination with lower environmental burden.
In summary, the findings of this dissertation has three general conclusions for improving emission and ecological efficiency in cities. Firstly, large cities in emerging nations face a huge challenge with respect to improving their emission efficiency. The task in front of these cities is threefold: (1) deploying efficient technologies for the generation of electricity and improvement of public transportation to unlock their leap frogging potential, (2) addressing the issue of energy poverty and (3) ensuring that these cities do not develop similar energy consumption patterns with infrastructure lock-in behavior similar to those of cities in developed regions. Secondly, the on-going urban sprawl as a global phenomenon will decrease the emission efficiency within the building and transportation sector. Therefore, local policy makers should identify adequate fiscal and land use policies to curb urban sprawl. Lastly, since mature cities with well-established economic structures are more eco-efficient and urbanites' perception re ects its combination with decreasing environmental burden; there is a need to adopt and implement strategies which enable socioeconomic growth in cities whilst decreasing their environment burden.
Cities to the rescue?
(2017)
Despite the proliferation and promise of subnational climate initiatives, the institutional architecture of transnational municipal networks (TMNs) is not well understood. With a view to close this research gap, the article empirically assesses the assumption that TMNs are a viable substitute for ambitious international action under the United Nations Framework Convention on Climate Change (UNFCCC). It addresses the aggregate phenomenon in terms of geographical distribution, central players, mitigation ambition and monitoring provisions. Examining thirteen networks, it finds that membership in TMNs is skewed toward Europe and North America while countries from the Global South are underrepresented; that only a minority of networks commit to quantified emission reductions and that these are not more ambitious than Parties to the UNFCCC; and finally that the monitoring provisions are fairly limited. In sum, the article shows that transnational municipal networks are not (yet) the representative, ambitious and transparent player they are thought to be.
Climate or land use?
(2017)
This study intends to contribute to the ongoing discussion on whether land use and land cover changes (LULC) or climate trends have the major influence on the observed increase of flood magnitudes in the Sahel. A simulation-based approach is used for attributing the observed trends to the postulated drivers. For this purpose, the ecohydrological model SWIM (Soil and Water Integrated Model) with a new, dynamic LULC module was set up for the Sahelian part of the Niger River until Niamey, including the main tributaries Sirba and Goroul. The model was driven with observed, reanalyzed climate and LULC data for the years 1950–2009. In order to quantify the shares of influence, one simulation was carried out with constant land cover as of 1950, and one including LULC. As quantitative measure, the gradients of the simulated trends were compared to the observed trend. The modeling studies showed that for the Sirba River only the simulation which included LULC was able to reproduce the observed trend. The simulation without LULC showed a positive trend for flood magnitudes, but underestimated the trend significantly. For the Goroul River and the local flood of the Niger River at Niamey, the simulations were only partly able to reproduce the observed trend. In conclusion, the new LULC module enabled some first quantitative insights into the relative influence of LULC and climatic changes. For the Sirba catchment, the results imply that LULC and climatic changes contribute in roughly equal shares to the observed increase in flooding. For the other parts of the subcatchment, the results are less clear but show, that climatic changes and LULC are drivers for the flood increase; however their shares cannot be quantified. Based on these modeling results, we argue for a two-pillar adaptation strategy to reduce current and future flood risk: Flood mitigation for reducing LULC-induced flood increase, and flood adaptation for a general reduction of flood vulnerability.
The Yukon Coast in Canada is an ice-rich permafrost coast and highly sensitive to changing environmental conditions. Retrogressive thaw slumps are a common thermoerosion feature along this coast, and develop through the thawing of exposed ice-rich permafrost on slopes and removal of accumulating debris. They contribute large amounts of sediment, including organic carbon and nitrogen, to the nearshore zone.
The objective of this study was to 1) identify the climatic and geomorphological drivers of sediment-meltwater release, 2) quantify the amount of released meltwater, sediment, organic carbon and nitrogen, and 3) project the evolution of sediment-meltwater release of retrogressive thaw slumps in a changing future climate.
The analysis is based on data collected over 18 days in July 2013 and 18 days in August 2012. A cut-throat flume was set up in the main sediment-meltwater channel of the largest retrogressive thaw slump on Herschel Island. In addition, two weather stations, one on top of the undisturbed tundra and one on the slump floor, measured incoming solar radiation, air temperature, wind speed and precipitation. The discharge volume eroding from the ice-rich permafrost and retreating snowbanks was measured and compared to the meteorological data collected in real time with a resolution of one minute.
The results show that the release of sediment-meltwater from thawing of the ice-rich permafrost headwall is strongly related to snowmelt, incoming solar radiation and air temperature. Snowmelt led to seasonal differences, especially due to the additional contribution of water to the eroding sediment-meltwater from headwall ablation, lead to dilution of the sediment-meltwater composition. Incoming solar radiation and air temperature were the main drivers for diurnal and inter-diurnal fluctuations. In July (2013), the retrogressive thaw slump released about 25 000 m³ of sediment-meltwater, containing 225 kg dissolved organic carbon and 2050 t of sediment, which in turn included 33 t organic carbon, and 4 t total nitrogen. In August (2012), just 15 600 m³ of sediment-meltwater was released, since there was no additional contribution from snowmelt. However, even without the additional dilution, 281 kg dissolved organic carbon was released. The sediment concentration was twice as high as in July, with sediment contents of up to 457 g l-1 and 3058 t of sediment, including 53 t organic carbon and 5 t nitrogen, being released.
In addition, the data from the 36 days of observations from Slump D were upscaled to cover the main summer season of 1 July to 31 August (62 days) and to include all 229 active retrogressive thaw slumps along the Yukon Coast. In total, all retrogressive thaw slumps along the Yukon Coast contribute a minimum of 1.4 Mio. m³ sediment-meltwater each thawing season, containing a minimum of 172 000 t sediment with 3119 t organic carbon, 327 t nitrogen and 17 t dissolved organic carbon. Therefore, in addition to the coastal erosion input to the Beaufort Sea, retrogressive thaw slumps additionally release 3 % of sediment and 8 % of organic carbon into the ocean. Finally, the future evolution of retrogressive thaw slumps under a warming scenario with summer air temperatures increasing by 2-3 °C by 2081-2100, would lead to an increase of 109-114% in release of sediment-meltwater.
It can be concluded that retrogressive thaw slumps are sensitive to climatic conditions and under projected future Arctic warming will contribute larger amounts of thawed permafrost material (including organic carbon and nitrogen) into the environment.
In general, a moderate drying trend is observed in mid-latitude arid Central Asia since the Mid-Holocene, attributed to the progressively weakening influence of the mid-latitude Westerlies on regional climate. However, as the spatio-temporal pattern of this development and the underlying climatic mechanisms are yet not fully understood, new high-resolution paleoclimate records from this region are needed. Within this study, a sediment core from Lake Son Kol (Central Kyrgyzstan) was investigated using sedimentological, (bio) geochemical, isotopic, and palynological analyses, aiming at reconstructing regional climate development during the last 6000 years. Biogeochemical data, mainly reflecting summer moisture conditions, indicate predominantly wet conditions until 4950 cal. yr BP, succeeded by a pronounced dry interval between 4950 and 3900 cal. yr BP. In the following, a return to wet conditions and a subsequent moderate drying trend until present times are observed. This is consistent with other regional paleoclimate records and likely reflects the gradual Late Holocene diminishment of the amount of summer moisture provided by the mid-latitude Westerlies. However, climate impact of the Westerlies was apparently not only restricted to the summer season but also significant during winter as indicated by recurrent episodes of enhanced allochthonous input through snowmelt, occurring before 6000 cal. yr BP and at 5100-4350, 3450-2850, and 1900-1500 cal. yr BP. The distinct similar to 1500year periodicity of these episodes of increased winter precipitation in Central Kyrgyzstan resembles similar cyclicities observed in paleoclimate records around the North Atlantic, likely indicating a hemispheric-scale climatic teleconnection and an impact of North Atlantic Oscillation (NAO) variability in Central Asia.
The performance of hybridization capture combined with next-generation sequencing (NGS) has seen limited investigation with samples from hot and arid regions until now. We applied hybridization capture and shotgun sequencing to recover DNA sequences from bone specimens of ancient-domestic dromedary (Camelus dromedarius) and its extinct ancestor, the wild dromedary from Jordan, Syria, Turkey and the Arabian Peninsula, respectively. Our results show that hybridization capture increased the percentage of mitochondrial DNA (mtDNA) recovery by an average 187-fold and in some cases yielded virtually complete mitochondrial (mt) genomes at multifold coverage in a single capture experiment. Furthermore, we tested the effect of hybridization temperature and time by using a touchdown approach on a limited number of samples. We observed no significant difference in the number of unique dromedary mtDNA reads retrieved with the standard capture compared to the touchdown method. In total, we obtained 14 partial mitochondrial genomes from ancient-domestic dromedaries with 17-95% length coverage and 1.27-47.1-fold read depths for the covered regions. Using whole-genome shotgun sequencing, we successfully recovered endogenous dromedary nuclear DNA (nuDNA) from domestic and wild dromedary specimens with 1-1.06-fold read depths for covered regions. Our results highlight that despite recent methodological advances, obtaining ancient DNA (aDNA) from specimens recovered from hot, arid environments is still problematic. Hybridization protocols require specific optimization, and samples at the limit of DNA preservation need multiple replications of DNA extraction and hybridization capture as has been shown previously for Middle Pleistocene specimens.