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We propose a generalization of the widely used fractional Brownian motion (FBM), memory-multi-FBM (MMFBM), to describe viscoelastic or persistent anomalous diffusion with time-dependent memory exponent α(t ) in a changing environment. In MMFBM the built-in, long-range memory is continuously modulated by α(t ). We derive the essential statistical properties of MMFBM such as its response function, mean-squared displacement (MSD), autocovariance function, and Gaussian distribution. In contrast to existing forms of FBM with time-varying memory exponents but a reset memory structure, the instantaneous dynamic of MMFBM is influenced by the process history, e.g., we show that after a steplike change of α(t ) the scaling exponent of the MSD after the α step may be determined by the value of α(t ) before the change. MMFBM is a versatile and useful process for correlated physical systems with nonequilibrium initial conditions in a changing environment.
Functional near-infrared spectroscopy (fNIRS) allows for a reliable assessment of oxygenated blood flow in relevant brain regions. Recent advancements in immersive virtual reality (VR)-based technology have generated many new possibilities for its application, such as in stroke rehabilitation. In this study, we asked whether there is a difference in oxygenated hemoglobin (HbO2) within brain motor areas during hand/arm movements between immersive and non-immersive VR settings. Ten healthy young participants (24.3 ± 3.7, three females) were tested using a specially developed VR paradigm, called “bus riding”, whereby participants used their hand to steer a moving bus. Both immersive and non-immersive conditions stimulated brain regions controlling hand movements, namely motor cortex, but no significant differences in HbO2 could be found between the two conditions in any of the relevant brain regions. These results are to be interpreted with caution, as only ten participants were included in the study.
In the Gasht-Masuleh area in the Alborz Mountains, gabbroic magma intruded Palaeozoic metasediments and Mesozoic sediments and crystallised as isotropic and cumulate gabbros. LREE enrichment points to relatively low degrees of mantle melting and depletion of Ti, Nb and Ta relative to primitive mantle points to an arc related component in the magma. Clinopyroxene compositions indicate MORB to arc signatures. U–Pb zircon crystallisation ages of 99.5 ± 0.6 Ma and 99.4 ± 0.6 Ma and phlogopite 40Ar/39Ar ages of 97.1 ± 0.4 Ma, 97.5 ± 0.4 Ma, 97.1 ± 0.1 Ma, within 2σ error, indicate that gabbro intrusion occurred in the (Albian-)Cenomanian (mid-Cretaceous). As active subduction did not take place in the Cretaceous in North Iran, the small volume mafic magmatism in the Gasht-Masuleh area must be due to local, extension-related mantle melting. Melting was most likely caused by far field effects triggered by roll-back of the Neo-Tethys subducting slab. As subduction took place at a distance of ~ 400 km (present distance) from the Alborz Mountains, the observed arc geochemical signatures must be inherited from a previous subduction event and concomitant mantle metasomatism, possibly in combination with contamination of the magma by crustal material.
We present real-world data processing on measured electron time-of-flight data via neural networks. Specifically, the use of disentangled variational autoencoders on data from a diagnostic instrument for online wavelength monitoring at the free electron laser FLASH in Hamburg. Without a-priori knowledge the network is able to find representations of single-shot FEL spectra, which have a low signal-to-noise ratio. This reveals, in a directly human-interpretable way, crucial information about the photon properties. The central photon energy and the intensity as well as very detector-specific features are identified. The network is also capable of data cleaning, i.e. denoising, as well as the removal of artefacts. In the reconstruction, this allows for identification of signatures with very low intensity which are hardly recognisable in the raw data. In this particular case, the network enhances the quality of the diagnostic analysis at FLASH. However, this unsupervised method also has the potential to improve the analysis of other similar types of spectroscopy data.
In recurrence analysis, the tau-recurrence rate encodes the periods of the cycles of the underlying high-dimensional time series. It, thus, plays a similar role to the autocorrelation for scalar time-series in encoding temporal correlations.
However, its Fourier decomposition does not have a clean interpretation. Thus, there is no satisfactory analogue to the power spectrum in recurrence analysis.
We introduce a novel method to decompose the tau-recurrence rate using an over-complete basis of Dirac combs together with sparsity regularization.
We show that this decomposition, the inter-spike spectrum, naturally provides an analogue to the power spectrum for recurrence analysis in the sense that it reveals the dominant periodicities of the underlying time series.
We show that the inter-spike spectrum correctly identifies patterns and transitions in the underlying system in a wide variety of examples and is robust to measurement noise.
Anger, indignation, guilt, rumination, victim compensation, and perpetrator punishment are considered primary responses associated with justice sensitivity (JS).
However, injustice and high JS may predispose to further responses.
We had N = 293 adults rate their JS, 17 potential responses toward 12 unjust scenarios from the victim's, observer's, beneficiary's, and perpetrator's perspectives, and several control variables.
Unjust situations generally elicited many affective, cognitive, and behavioral responses. JS generally predisposed to strong affective responses toward injustice, including sadness, pity, disappointment, and helplessness. It impaired trivialization, victim-blaming, or justification, which may otherwise help cope with injustice.
It predisposed to conflict solutions and victim compensation. Particularly victim and beneficiary JS had stronger effects in unjust situations from the corresponding perspective.
These findings add to a better understanding of the main and interaction effects of unjust situations from different perspectives and the JS facets, differences between the JS facets, as well as the links between JS and behavior and well-being.
The pathogenesis of influenza A viruses (IAVs) is influenced by several factors, including IAV strain origin and reassortment, tissue tropism and host type. While such factors were mostly investigated in the context of virus entry, fusion and replication, little is known about the viral-induced changes to the host lipid membranes which might be relevant in the context of virion assembly. In this work, we applied several biophysical fluorescence microscope techniques (i.e., Förster energy resonance transfer, generalized polarization imaging and scanning fluorescence correlation spectroscopy) to quantify the effect of infection by two IAV strains of different origin on the plasma membrane (PM) of avian and human cell lines. We found that IAV infection affects the membrane charge of the inner leaflet of the PM. Moreover, we showed that IAV infection impacts lipid–lipid interactions by decreasing membrane fluidity and increasing lipid packing. Because of such alterations, diffusive dynamics of membrane-associated proteins are hindered. Taken together, our results indicate that the infection of avian and human cell lines with IAV strains of different origins had similar effects on the biophysical properties of the PM.
Auslandserfahrung wird von vielen Kanzleien und Unternehmen im Einstellungsprozess geschätzt. Sie beweist, dass Bewerber:innen Sprachkenntnisse, interkulturelle Kompetenzen und Organisationsfähigkeiten erworben haben. Trotzdem bestehen bei Studierenden oft Bedenken, ob und wie sie ein Auslandssemester in das rechtswissenschaftliche Studium einbauen sollen.
Deshalb möchte dieser Beitrag hilfreiche Antworten und Tipps geben, wie Jurastudierende der Universität Potsdam das Auslandssemester bestmöglich integrieren können. Er soll als Ermutigung dienen, sich dafür zu bewerben.
Dieser Beitrag ist in drei Abschnitte eingeteilt. Zuerst möchte ich auf den vermeintlich „richtigen“ Zeitpunkt für ein Auslandssemester eingehen. Danach stelle ich dar, welche Leistungen gut anrechenbar sind. Zuletzt möchte ich sowohl die Nachteile als auch die Vorteile eines Erasmus-Semesters aus eigener Erfahrung vorstellen.
Background: Socially assistive devices (care robots, companions, smart screen assistants) have been advocated as a promising tool in elderly care in Western healthcare systems. Ethical debates indicate various challenges. One of the most prevalent arguments in the debate is the double-benefit argument claiming that socially assistive devices may not only provide benefits for autonomy and well-being of their users but might also be more efficient than other caring practices and might help to mitigate scarce resources in healthcare. Against this background, we used a subset of comparative empirical studies from a comprehensive systematic review on effects and perceptions of human-machine interaction with socially assistive devices to gather and appraise all available evidence supporting this argument from the empirical side.
Methods: Electronic databases and additional sources were queried using a comprehensive search strategy which generated 9851 records. Studies were screened independently by two authors. Methodological quality of studies was assessed. For 39 reports using a comparative study design, a narrative synthesis was performed.
Results: The data shows positive evidential support to claim that some socially assistive devices (Paro) might be able to contribute to the well-being and autonomy of their users. However, results also indicate that these positive findings may be heavily dependent on the context of use and the population. In addition, we found evidence that socially assistive devices can have negative effects on certain populations. Evidence regarding the claim of efficiency is scarce. Existing results indicate that socially assistive devices can be more effective than standard of care but are far less effective than plush toys or placebo devices.
Discussion: We suggest using the double-benefit argument with great caution as it is not supported by the currently available evidence. The occurrence of potentially negative effects of socially assistive devices requires more research and indicates a more complex ethical calculus than suggested by the double-benefit argument.
Organic thin films are widely used in organic electronics and coatings. Such films often feature film-depth dependent variations of composition and optoelectronic properties. State-of-the-art depth profiling methods such as mass spectroscopy and photoelectron spectroscopy rely on non-intrinsic species (vaporized ions, etching-induced surface defects), which are chemically and functionally different from the original materials. Here we introduce an easily-accessible and generally applicable depth profiling method: film-depth-dependent infrared (FDD-IR) spectroscopy profilometry based on directly measuring the intrinsic material after incremental surface-selective etching by a soft plasma, to study the material variations along the surface-normal direction. This depth profiling uses characteristic vibrational signatures of the involved compounds, and can be used for both conjugated and non-conjugated, neutral and ionic materials. A film-depth resolution of one nanometer is achieved. We demonstrate the application of this method for investigation of device-relevant thin films, including organic field-effect transistors and organic photovoltaic cells, as well as ionized dopant distributions in doped semiconductors.
RangeShifter 2.0
(2021)
Process-based models are becoming increasingly used tools for understanding how species are likely to respond to environmental changes and to potential management options. RangeShifter is one such modelling platform, which has been used to address a range of questions including identifying effective reintroduction strategies, understanding patterns of range expansion and assessing population viability of species across complex landscapes. Here we introduce a new version, RangeShifter 2.0, which incorporates important new functionality. It is now possible to simulate dynamics over user-specified, temporally changing landscapes. Additionally, we integrated a new genetic module, notably introducing an explicit genetic modelling architecture, which allows for simulation of neutral and adaptive genetic processes. Furthermore, emigration, transfer and settlement traits can now all evolve, allowing for sophisticated simulation of the evolution of dispersal. We illustrate the potential application of RangeShifter 2.0's new functionality by two examples. The first illustrates the range expansion of a virtual species across a dynamically changing UK landscape. The second demonstrates how the software can be used to explore the concept of evolving connectivity in response to land-use modification, by examining how movement rules come under selection over landscapes of different structure and composition. RangeShifter 2.0 is built using object-oriented C++ providing computationally efficient simulation of complex individual-based, eco-evolutionary models. The code has been redeveloped to enable use across operating systems, including on high performance computing clusters, and the Windows graphical user interface has been enhanced. RangeShifter 2.0 will facilitate the development of in-silico assessments of how species will respond to environmental changes and to potential management options for conserving or controlling them. By making the code available open source, we hope to inspire further collaborations and extensions by the ecological community.
Wer ist neu an der Fakultät?
(2024)
Wir freuen uns Herr Prof. Dr. Meinert und Herr Prof. Dr. Ismer an der Universität Potsdam begrüßen zu dürfen. Beide eint nicht nur, dass sie neu an der Fakultät sind, sondern auch ihre Vorliebe für das Steuerrecht. Wir durften beide interviewen und möchten sie Ihnen nun näher vorstellen.
Herr RiFG PD Dr. Carsten Meinert, Dipl.- Finw. (FH) arbeitet seit dem 1. Oktober 2023 als Professor für Bürgerliches Recht, Unternehmens- und Steuerrecht, als Nachfolger von Herrn Prof. Bezzenberger, an der Universität Potsdam. Wir freuen uns sehr, dass Herr Prof. Meinert den Ruf der Universität Potsdam auf die Professur angenommen hat.
Herr. Prof. Dr. Roland Ismer, ist seit dem 1. April 2024 neuer Inhaber der Professur für Öffentliches Recht und Steuerrecht und tritt damit die Nachfolge des im Sommer 2022 verstorbenen Herrn. Prof. Musil an. Weiterhin übernimmt Herr Prof. Ismer die Masterstudiengänge „Unternehmens- und Steuerrecht (LL.M.)“ sowie „Steurerrecht (LL.M.)“. Wir freuen uns sehr, dass Herr Prof. Ismer nun die Universität Potsdam bereichert.
Leishmaniasis is a vector-borne disease caused by protozoal Leishmania parasites. Previous studies have shown that endoperoxides (EP) can selectively kill Leishmania in host cells.
Therefore, we studied in this work a set of new anthracene-derived EP (AcEP) together with their non-endoperoxidic analogs in model systems of Leishmania tarentolae promastigotes (LtP) and J774 macrophages for their antileishmanial activity and selectivity.
The mechanism of effective compounds was explored by studying their reaction with iron (II) in chemical systems and in Leishmania. The correlation of structural parameters with activity demonstrated that in this compound set, active compounds had a LogP(OW) larger than 3.5 and a polar surface area smaller than 100 angstrom(2).
The most effective compounds (IC50 in LtP < 2 mu M) with the highest selectivity (SI > 30) were pyridyl-/tert-butyl-substituted AcEP.
Interestingly, also their analogs demonstrated activity and selectivity. In mechanistic studies, it was shown that EP were activated by iron in chemical systems and in LtP due to their EP group.
However, the molecular structure beyond the EP group significantly contributed to their differential mitochondrial inhibition in Leishmania.
The identified compound pairs are a good starting point for subsequent experiments in pathogenic Leishmania in vitro and in animal models.
Nanoporous microparticles prepared from poly(ether imide) (PEI) are discussed as candidate adsorber materials for the removal of uremic toxins during apheresis. Polymers exhibiting such porosity can induce the formation of micro-gas/air pockets when exposed to fluids. Such air presenting material surfaces are reported to induce platelet activation and thrombus formation. Physical or chemical treatments prior to implantation are discussed to reduce the formation of such gas nuclei. Here, we report about the influence of different rewetting procedures - as chemical treatments with solvents on the thrombogenicity of hydrophobic PEI microparticles and PEI microparticles hydrophilized by covalent attachment of poly(vinyl pyrrolidone) (PVP) of two different chain lengths. <br /> Autoclaved dry PEI particles of all types with a diameter range of 200 - 250 mu m and a porosity of about 84%+/- 2% were either rewetted directly with phosphate buffered saline (24 h) or after immersion in an ethanol-series. Thrombogenicity of the particles was studied in vitro upon contact with human sodium citrated whole blood for 60 min at 5 rpm vertical rotation. Numbers of non-adherent platelets were quantified, and adhesion of blood cells was qualitatively analyzed by bright field microscopy. Platelet activation (percentage of CD62P positive platelets and amounts of soluble P-Selectin) and platelet function (PFA100 closure times) were analysed. <br /> Retention of blood platelets on the particles was similar for all particle types and both rewetting procedures. Non-adherent platelets were less activated after contact with ethanol-treated particles of all types compared to those rewetted with phosphate buffered saline as assessed by a reduced number of CD62P-positive platelets and reduced amounts of secreted P-Selectin (P < 0.05 each). Interestingly, the hydrophilic surfaces significantly increased the number of activated platelets compared to hydrophobic PEI regardless of the rewetting agent. This suggests that, apart from wettability, other material properties might be more important to regulate platelet activation. PFA100 closure times were reduced and within the reference ranges in the ethanol group, however, significantly increased in the saline group. No substantial difference was detected between the tested surface modifications. In summary, rewetting with ethanol resulted in a reduced thrombogenicity of all studied microparticles regardless of their wettability, most likely resulting from the evacuation of air from the nanoporous particles.
KI in der Justiz
(2024)
Gravitational waves emitted from the coalescence of neutron star binaries open a new window to probe matter and fundamental physics in unexplored, extreme regimes. To extract information about the supranuclear matter inside neutron stars and the properties of the compact binary systems, robust theoretical prescriptions are required. We give an overview about general features of the dynamics and the gravitational wave signal during the binary neutron star coalescence. We briefly describe existing analytical and numerical approaches to investigate the highly dynamical, strong-field region during the merger. We review existing waveform approximants and discuss properties and possible advantages and shortcomings of individual waveform models, and their application for real gravitational-wave data analysis.
Die Klausur wurde für den früheren Teil- schwerpunkt Kulturrecht am Fachbereich Rechts- und Wirtschaftswissenschaft der Johannes Gutenberg-Universität Mainz konzipiert, eignet sich aber auch für die Vorbereitung auf die staatliche Pflichtfach- prüfung sowie für den Schwerpunkt Wirtschaft-Staat-Kommunales (SPB 7).
Animal societies are structured of dominance hierarchy (DH). DH can be viewed as networks and analyzed by graph theory. We study the impact of state-dependent feedback (winner-loser effect) on the emergence of local dominance structures after pairwise contests between initially equal-ranking members (equal resource-holding-power, RHP) of small and large social groups. We simulated pairwise agonistic contests between individuals with and without a priori higher RHP by Monte-Carlo-method. Random pairwise contests between equal-ranking competitors result in random dominance structures (‘Null variant’) that are low in transitive triads and high in pass along triads; whereas state-dependent feedback (‘Winner-loser variant’) yields centralized ‘star’ structured DH that evolve from competitors with initially equal RHP and correspond to hierarchies that evolve from keystone individuals. Monte-Carlo simulated DH following state-dependent feedback show motif patterns very similar to those of a variety of natural DH, suggesting that state-dependent feedback plays a pivotal role in robust self-organizing phenomena that transcend the specifics of the individual. Self-organization based on state-dependent feedback leads to social structures that correspond to those resulting from pre-existing keystone individuals. As the efficiency of centralized social networks benefits both, the individual and the group, centralization of social networks appears to be an important evolutionary goal.
Exotitische Zutaten
(2024)
In this study, the synthesis of new 5 (2-x-phenyl)-N,N-dimethyl-2H-tetrazole-2-carboxamides (X = H and Cl) is reported coupled with the investigation of their dynamic H-1-NMR via rotation about C-N bonds in the moiety of urea group [a; CO-NMe2] in DMSO solvent (298-373 K). Accordingly, activation free energies of 17.32 and 17.50 kcal mol(-1) were obtained for X = H and Cl respectively, with respect to the conformational isomerization about the Me2N-C=O bond (a rotation). Moreover, a and b [b; 2-tetrazolyl-CO rotations] barrier to rotations in 5-(2-x-phenyl)-N,N-dimethyl-2H-tetrazole-2-carboxamides were also calculated by B3LYP/6-311++G** procedure. The optimized geometry parameters are well consistent with the X-ray data. Computed rotational energy barriers (X = Cl) for a and b were estimated to be 17.52 and 2.53 kcal mol(-1), respectively, the former in agreement with the dynamic NMR results. X-ray structures verify that just 2-acylated tetrazoles are formed in the case of 5-(2-x-phenyl)-N,N-dimethyl-2H-tetrazole-2-carboxamides. A planar trigonal orientation of the Me2N group was proven by X-ray data, which is coplanar to the carbonyl group, coupled with partial double bond C-N character. This also illustrates the syn-periplanar position of the tetrazolyl ring with C=O group. In solution, the planes containing tetrazolyl ring and the carbonyl bond are almost perpendicular to each other (because of steric effects as confirmed by calculations) while the planes containing carbonyl bond and Me2N group are coplanar. This phenomenon is in contrast with similar urea derivatives and explains the reason for the unusually high rotational energy barrier of these compounds. (C) 2020 Elsevier B.V. All rights reserved.
SONAR
(2023)
Accurate and comprehensive nursing documentation is essential to ensure quality patient care. To streamline this process, we present SONAR, a publicly available dataset of nursing activities recorded using inertial sensors in a nursing home. The dataset includes 14 sensor streams, such as acceleration and angular velocity, and 23 activities recorded by 14 caregivers using five sensors for 61.7 hours. The caregivers wore the sensors as they performed their daily tasks, allowing for continuous monitoring of their activities. We additionally provide machine learning models that recognize the nursing activities given the sensor data. In particular, we present benchmarks for three deep learning model architectures and evaluate their performance using different metrics and sensor locations. Our dataset, which can be used for research on sensor-based human activity recognition in real-world settings, has the potential to improve nursing care by providing valuable insights that can identify areas for improvement, facilitate accurate documentation, and tailor care to specific patient conditions.
Background:
Despite an increasing demand for surgical treatment of lipedema, the evidence for liposuction is still limited. Little is known about the influence of disease stage, patient age, body mass index, or existing comorbidities on clinical outcomes.
It was hypothesized that younger patients with lower body mass index and stage would report better results.
Methods:
This retrospective, single-center, noncomparative study included lipedema patients who underwent liposuction between July of 2009 and July of 2019.
After a minimum of 6 months since the last surgery, all patients completed a disease-related questionnaire. The primary endpoint was the need for complex decongestive therapy based on a composite score. Secondary endpoints were the severity of disease-related complaints measured on a visual analogue scale.
Results:
One hundred six patients underwent a total of 298 large-volume liposuctions (mean lipoaspirate, 6355 +/- 2797 ml). After a median follow-up of 20 months, a median complex decongestive therapy score reduction of 37.5 percent (interquartile range, 0 to 88.8 percent; p < 0.0001) was observed.
An improvement in lipedema-associated symptoms was also observed (p < 0.0001). The percentage reduction in complex decongestive therapy scores was greater in patients with a body mass index less than or equal to 35 kg/m(2) (p < 0.0001) and in stage I and II patients (p = 0.0019).
Conclusion:
Liposuction reduces the severity of symptoms and the need for conservative treatment in lipedema patients, especially if it is performed in patients with a body mass index below 35 kg/m(2) at an early stage of the disease.
Late Miocene-Pliocene onset of fluvial incision of the Cauca River Canyon in the Northern Andes
(2022)
The incision of kilometer-scale canyons into high-standing topography is often used to constrain the surface uplift history of mountain ranges, controlled by tectonic and geodynamic processes.
However, changes in climate may also be responsible for canyon incision. This study deciphers the timing of incision of the similar to 2.5-km-deep Cauca River Canyon in the Central Cordillera of the Northern Andes using the cooling (exhumation) history of rocks from the canyon walls and a regional analysis of channel steepness in rivers.
Ten bedrock samples and one detrital sample were collected on the eastern border of the canyon between 300 m and 2300 m of elevation.
Bedrock and detrital AFT data yield ages from 50 to 38 Ma, while two bed-rock AHe ages from the valley bottom yield ages of 7-6 Ma.
The AHe ages and inverse thermal history models reveal a previously unidentified late Miocene (ca. 7-6 Ma) pulse of exhumation that we interpret as the age of a single incision event that formed the Cauca River Canyon.
We conclude that the Cauca River Canyon was carved as a response to rock uplift in the northern Central Cordillera and propagation of an erosion wave into the mountain range starting in the latest Miocene.
Small temporary wetlands, like kettle holes, provide many valuable ecosystem functions and serve as refuge habitats in otherwise monotonous agricultural landscapes. However, the mechanisms that maintain biodiversity in these habitats are still poorly understood. In this study, we investigate how three taxa (vascular plants, ground beetles and spiders) respond to small-scale flooding and disturbance gradients in kettle holes as well as kettle hole area. For this purpose, we determined total, hygrophilic and red list species richness for all taxa and activity density for arthropods along transects extending from the edge towards the center of kettle holes. Furthermore, we calculated the community-weighted mean body size for arthropods and seed mass for plants as surrogates for the ability to respond to disturbance. Our analyses revealed that in particular plants and ground beetles showed strong responses along the small-scale spatial gradient. Total plant species richness decreased towards the center, while hygrophilic plant species increased. In contrast, both total and hygrophilic species richness of ground beetles increased towards the center. Spiders showed similar responses as ground beetles, but less pronounced. We found no evidence that disturbance at the edge of kettle holes leads to smaller body sizes or seed masses. However, arthropods in adjacent arable fields (one meter from the kettle hole edge) were particularly small. Kettle hole area had only weak effects on plants, but not on arthropods. Our study indicates that differences in the depth at the drier edge and the moist, regularly flooded center have a large and taxon-dependent influence on the species composition. Therefore, small-scale heterogeneity seems to be an important predictor for the maintenance of species diversity.
Formate dehydrogenases catalyze the reversible oxidation of formate to carbon dioxide. These enzymes play an important role in CO2 reduction and serve as nicotinamide cofactor recycling enzymes. More recently, the CO2-reducing activity of formate dehydrogenases, especially metal-containing formate dehydrogenases, has been further explored for efficient atmospheric CO2 capture. Here, we investigate the nicotinamide binding site of formate dehydrogenase from Rhodobacter capsulatus for its specificity toward NAD+ vs. NADP+ reduction. Starting from the NAD+-specific wild-type RcFDH, key residues were exchanged to enable NADP+ binding on the basis of the NAD+-bound cryo-EM structure (PDB-ID: 6TG9). It has been observed that the lysine at position 157 (Lys157) in the β-subunit of the enzyme is essential for the binding of NAD+. RcFDH variants that had Glu259 exchanged for either a positively charged or uncharged amino acid had additional activity with NADP+. The FdsBL279R and FdsBK276A variants also showed activity with NADP+. Kinetic parameters for all the variants were determined and tested for activity in CO2 reduction. The variants were able to reduce CO2 using NADPH as an electron donor in a coupled assay with phosphite dehydrogenase (PTDH), which regenerates NADPH. This makes the enzyme suitable for applications where it can be coupled with other enzymes that use NADPH.
Housing in metabolic cages can induce a pronounced stress response. Metabolic cage systems imply housing mice on metal wire mesh for the collection of urine and feces in addition to monitoring food and water intake. Moreover, mice are single-housed, and no nesting, bedding, or enrichment material is provided, which is often argued to have a not negligible impact on animal welfare due to cold stress. We therefore attempted to reduce stress during metabolic cage housing for mice by comparing an innovative metabolic cage (IMC) with a commercially available metabolic cage from Tecniplast GmbH (TMC) and a control cage. Substantial refinement measures were incorporated into the IMC cage design. In the frame of a multifactorial approach for severity assessment, parameters such as body weight, body composition, food intake, cage and body surface temperature (thermal imaging), mRNA expression of uncoupling protein 1 (Ucp1) in brown adipose tissue (BAT), fur score, and fecal corticosterone metabolites (CMs) were included. Female and male C57BL/6J mice were single-housed for 24 h in either conventional Macrolon cages (control), IMC, or TMC for two sessions. Body weight decreased less in the IMC (females—1st restraint: −6.94%; 2nd restraint: −6.89%; males—1st restraint: −8.08%; 2nd restraint: −5.82%) compared to the TMC (females—1st restraint: −13.2%; 2nd restraint: −15.0%; males—1st restraint: −13.1%; 2nd restraint: −14.9%) and the IMC possessed a higher cage temperature (females—1st restraint: 23.7 °C; 2nd restraint: 23.5 °C; males—1st restraint: 23.3 °C; 2nd restraint: 23.5 °C) compared with the TMC (females—1st restraint: 22.4 °C; 2nd restraint: 22.5 °C; males—1st restraint: 22.6 °C; 2nd restraint: 22.4 °C). The concentration of fecal corticosterone metabolites in the TMC (females—1st restraint: 1376 ng/g dry weight (DW); 2nd restraint: 2098 ng/g DW; males—1st restraint: 1030 ng/g DW; 2nd restraint: 1163 ng/g DW) was higher compared to control cage housing (females—1st restraint: 640 ng/g DW; 2nd restraint: 941 ng/g DW; males—1st restraint: 504 ng/g DW; 2nd restraint: 537 ng/g DW). Our results show the stress potential induced by metabolic cage restraint that is markedly influenced by the lower housing temperature. The IMC represents a first attempt to target cold stress reduction during metabolic cage application thereby producing more animal welfare friendlydata.
The order of destruction
(2024)
This book studies sugarcane monoculture, the dominant form of cultivation in the colonial Caribbean, in the later 1600s and 1700s up to the Haitian Revolution. Researching travel literature, plantation manuals, Georgic poetry, letters, and political proclamations, this book interprets texts by Richard Ligon, Henry Drax, James Grainger, Janet Schaw, and Toussaint Louverture. As the first extended investigation into its topic, this book reads colonial Caribbean monoculture as the conjunction of racial capitalism and agrarian capitalism in the tropics. Its eco-Marxist perspective highlights the dual exploitation of the soil and of enslaved agricultural producers under the plantation regime, thereby extending Marxist analysis to the early colonial Caribbean. By focusing on textual form (in literary and non-literary texts alike), this study discloses the bearing of monoculture on contemporary writers' thoughts. In the process, it emphasizes the significance of a literary tradition that, despite its ideological importance, is frequently neglected in (postcolonial) literary studies and the environmental humanities. Located at a crossroads of disciplines and perspectives, this study will be of interest to literary critics and historians working in the early Americas, to students and scholars of agriculture, colonialism, and (racial) capitalism, to those working in the environmental humanities, and to Marxist academics. It will be of great interest to scholars and researchers of language and literature, post-colonial studies, cultural studies, diaspora studies, and the Global South studies
We present SURFER, a novel reduced model for estimating the impact of CO2 emissions and solar radiation modification options on sea level rise and ocean acidification over timescales of several thousands of years.
SURFER has been designed for the analysis of CO2 emission and solar radiation modification policies, for supporting the computation of optimal (CO2 emission and solar radiation modification) policies and for the study of commitment and responsibility under uncertainty.
The model is based on a combination of conservation laws for the masses of atmospheric and oceanic carbon and for the oceanic temperature anomalies, and of adhoc parameterisations for the different sea level rise contributors: ice sheets, glaciers and ocean thermal expansion. It consists of 9 loosely coupled ordinary differential equations, is understandable, fast and easy to modify and calibrate.
It reproduces the results of more sophisticated, high-dimensional earth system models on timescales up to millennia.
The ‘social brain’, consisting of areas sensitive to social information, supposedly gates the mechanisms involved in human language learning. Early preverbal interactions are guided by ostensive signals, such as gaze patterns, which are coordinated across body, brain, and environment. However, little is known about how the infant brain processes social gaze in naturalistic interactions and how this relates to infant language development. During free-play of 9-month-olds with their mothers, we recorded hemodynamic cortical activity of ´social brain` areas (prefrontal cortex, temporo-parietal junctions) via fNIRS, and micro-coded mother’s and infant’s social gaze. Infants’ speech processing was assessed with a word segmentation task. Using joint recurrence quantification analysis, we examined the connection between infants’ ´social brain` activity and the temporal dynamics of social gaze at intrapersonal (i.e., infant’s coordination, maternal coordination) and interpersonal (i.e., dyadic coupling) levels. Regression modeling revealed that intrapersonal dynamics in maternal social gaze (but not infant’s coordination or dyadic coupling) coordinated significantly with infant’s cortical activity. Moreover, recurrence quantification analysis revealed that intrapersonal maternal social gaze dynamics (in terms of entropy) were the best predictor of infants’ word segmentation. The findings support the importance of social interaction in language development, particularly highlighting maternal social gaze dynamics.
A minimal light-driven approach was established for studying enzymatic CO2 conversion spectroscopically. The system consists of a photosensitizer Eosin Y, EDTA as a sacrificial electron donor and substrate source, and formate dehydrogenase from Rhodobacter capsulatus (RcFDH) as a biocatalyst. This simplified three-component system provides a photo-triggered control for in situ characterization of the entire catalytic reaction. Direct reduction of RcFDH by the photosensitizer without additional electron carriers was confirmed via UV-Vis spectroscopy, while GC-MS and IR spectroscopy were used to follow photoinduced CO2 generation from EDTA and its subsequent enzymatic reduction, yielding the product formate. Photo-driven and in vitro, dye-based CO2 reduction was inhibited by azide under a mixed (competitive-non-competitive) inhibition mode. IR spectroscopy reveals displacement of the competitively-bound azide by CO2, reflecting an interaction of both with the active site cofactor. This work comprises a proof-of-concept for a new approach to employ light for regulating the reaction of formate dehydrogenases and other CO2 reductases.
Carl Bergmann was an astute naturalist and physiologist. His ideas about animal size and shape were important advances in the pre-Darwinian nineteenth century. Bergmann's rule claims that that in cold climates, large body mass increases the ratio of volume-to-surface area and provides for maximum metabolic heat retention in mammals and birds. Conversely, in warmer temperatures, smaller body mass increases surface area relative to volume and allows for greater heat loss. For humans, we now know that body size and shape are regulated more by social-economic-political-emotional (SEPE) factors as well as nutrition-infection interactions. Temperature has virtually no effect. Bergmann's rule is a "just-so" story and should be relegated to teaching and scholarship about the history of science. That "rule" is no longer acceptable science and has nothing to tell us about physiological anthropology.
Since the first reported case of COVID-19 in 2019 in China and the official declaration from the World Health Organization in March 2021 as a pandemic, fast and accurate diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has played a major role worldwide. For this reason, various methods have been developed, comprising reverse transcriptase-polymerase chain reaction (RT-PCR), immunoassays, clustered regularly interspaced short palindromic repeats (CRISPR), reverse transcription loop-mediated isothermal amplification (RT-LAMP), and bio(mimetic)sensors. Among the developed methods, RT-PCR is so far the gold standard. Herein, we give an overview of the MIP-based sensors utilized since the beginning of the pandemic.
Ein neuer Krieg?
(2024)
Strain NGK35T is a motile, Gram-stain-negative, rod-shaped (1.0-2.1 mu m long and 0.6-0.8 mu m wide), aerobic bacterium that was isolated from plastic-polluted landfill soil. The strain grew at temperatures between 6 and 37 degrees C (optimum, 28 degrees C), in 0-10 % NaCl (optimum, 1 %) and at pH 6.0-9.5 (optimum, pH 7.5-8.5).
It was positive for cytochrome c oxidase, catalase as well as H2S production, and hydrolysed casein and urea. It used a variety of different carbon sources including citrate, lactate and pyruvate.
The predominant membrane fatty acids were C-16:1 cis9 and C-16:0, followed by C-17:0 cyclo and C-18:1 cis11. The major polar lipids were phosphatidylglycerol and phosphatidylethanolamine, followed by diphosphatidyglycerol. The only quinone was ubiquinone Q-8. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain NGK35(T) belongs to the genus Paenalcaligenes (family Alcaligenaceae), appearing most closely related to Paenalcaligenes hominis CCUG 53761A(T) (96.90 %) and Paenalcaligenes suwonensis ABC02-12(T) (96.94 %).
The genomic DNA G+C content of strain NGK35(T) was 52.1 mol%. Genome-based calculations (genome-to-genome distance, average nucleotide identity and DNA G+C content) clearly indicated that the isolate represents a novel species within the genus Paenalcaligenes.
Based on phenotypic and molecular characterization, strain NGK35(T) can clearly be differentiated from its phylogenetic neighbours establishing a novel species, for which the name Paenalcaligenes niemegkensis sp. nov. is proposed.
The type strain is NGK35T (=DSM 113270(T)=NCCB 100854(T)).
Tropical cyclones range among the costliest of all meteorological events worldwide and planetary scale warming provides more energy and moisture to these storms. Modelling the national and global economic repercussions of 2017's Hurricane Harvey, we find a qualitative change in the global economic response in an increasingly warmer world.
While the United States were able to balance regional production failures by the original 2017 hurricane, this option becomes less viable under future warming.
In our simulations of over 7000 regional economic sectors with more than 1.8 million supply chain connections, the US are not able to offset the losses by use of national efforts with intensifying hurricanes under unabated warming.
At a certain warming level other countries have to step in to supply the necessary goods for production, which gives US economic sectors a competitive disadvantage. In the highly localized mining and quarrying sector-which here also comprises the oil and gas production industry-this disadvantage emerges already with the original Hurricane Harvey and intensifies under warming.
Eventually, also other regions reach their limit of what they can offset.
While we chose the example of a specific hurricane impacting a specific region, the mechanism is likely applicable to other climate-related events in other regions and other sectors.
It is thus likely that the regional economic sectors that are best adapted to climate change gain significant advantage over their competitors under future warming.
Background:
The medical care of patients with myositis is a great challenge in clinical practice. This is due to the rarity of these disease, the complexity of diagnosis and management as well as the lack of systematic analyses.
Objectives:
Therefore, the aim of this project was to obtain an overview of the current care of myositis patients in Germany and to evaluate epidemiological trends in recent years.
Methods:
In collaboration with BARMER Insurance, retrospective analysis of outpatient and inpatient data from an average of approximately 8.7 million insured patients between January 2005 and December 2019 was performed using ICD-10 codes for myositis for identification of relevant data.
In addition, a comparative analysis was performed between myositis patients and an age-matched comparison group from other populations insured by BARMER.
Results:
45,800 BARMER-insured individuals received a diagnosis of myositis during the observation period, with a relatively stable prevalence throughout. With regard to comorbidities, a significantly higher rate of cardiovascular disease as well as neoplasm was observed compared to the control group within the BARMER-insured population. In addition, myositis patients suffer more frequently from psychiatric disorders, such as depression and somatoform disorders.
However, the ICD-10 catalogue only includes the specific coding of "dermatomyositis" and "polymyositis" and thus does not allow for a sufficient analysis of all idiopathic inflammatory myopathies subtypes.
Conclusion:
The current data provide a comprehensive epidemiological analysis of myositis in Germany, highlighting the multimorbidity of myositis patients. This underlines the need for multidisciplinary management. However, the ICD-10 codes currently still in use do not allow for specific analysis of the subtypes of myositis.
The upcoming ICD-11 coding may improve future analyses in this regard.
Einleitung
(2024)
The bulk built-in current sensor (BBICS) is a cost-effective solution for detection of energetic particle strikes in integrated circuits.
With an appropriate number of BBICSs distributed across the chip, the soft error locations can be identified, and the dynamic fault-tolerant mechanisms can be activated locally to correct the soft errors in the affected logic.
In this work, we introduce a pulse stretching BBICS (PS-BBICS) constructed by connecting a standard BBICS and a custom-designed pulse stretching cell.
The aim of PS-BBICS is to enable the on-chip measurement of the single event transient (SET) pulse width, allowing to detect the linear energy transfer (LET) of incident particles, and thus assess more accurately the radiation conditions.
Based on Spectre simula-tions, we have shown that for the LET from 1 to 100 MeV cm2 mg -1, the SET pulse width detected by PS-BBICS varies by 620-800 ps. The threshold LET of PS-BBICS increases linearly with the number of monitored inverters, and it is around 1.7 MeV cm2 mg- 1 for ten monitored inverters.
On the other hand, the SET pulse width is in-dependent of the number of monitored inverters for LET > 4 MeV cm2 mg -1. It was shown that supply voltage, temperature and process variations have strong impact on the response of PS-BBICS.
Background:
Polycystic ovary syndrome (PCOS) is an endocrine disease in which related to obesity, metabolic disorders and is considered as one of the main causes of infertility in women. This trial was investigated the effects of green cardamom on the expression of genes implicated in obesity and diabetes among obese women with PCOS.
Methods:
One hundred ninety-four PCOS women were randomly divided two groups: intervention (n = 99; 3 g/day green cardamom) and control groups (n = 95). All of them were given low calorie diet. Anthropometric, glycemic and androgen hormones were assessed before and after 16-week intervention. The reverse transcription-polymerase chain reaction (RT-PCR) method was used to measure fat mass and obesity-associated (FTO), peroxisome proliferative activating receptor- (PPAR-), carnitine palmitoyltransferase 1A (CPT1A), acetyl-CoA carboxylase beta (ACAB), leptin receptor (LEPR), ghrelin, and lamin A/C (LAMIN) genes expression in each group.
Results:
Anthropometric indices were significantly decreased after intervention in both two studied groups. Glycemic indices and androgen hormones were significantly improved in the intervention group compared to the control group. The expression levels of FTO, CPT1A, LEPR, and LAMIN were significantly downregulated compared to control group (P < 0.001), as well as, PPAR-y was significantly upregulated in the intervention group after intervention with green cardamom compared to control group (P < 0.001).
Conclusion:
This current study showed that the administration of green cardamom is a beneficial approach for improving anthropometric, glycemic, and androgen hormones, as well as obesity and diabetes genes expression in PCOS women under the low-calorie diet.
Photosynthetic activity in both algae and cyanobacteria changes in response to cues of predation
(2022)
A plethora of adaptive responses to predation has been described in microscopic aquatic producers.
Although the energetic costs of these responses are expected, with their consequences going far beyond an individual, their underlying molecular and metabolic mechanisms are not fully known.
One, so far hardly considered, is if and how the photosynthetic efficiency of phytoplankton might change in response to the predation cues. Our main aim was to identify such responses in phytoplankton and to detect if they are taxon-specific.
We exposed seven algae and seven cyanobacteria species to the chemical cues of an efficient consumer, Daphnia magna, which was fed either a green alga, Acutodesmus obliquus, or a cyanobacterium, Synechococcus elongatus (kairomone and alarm cues), or was not fed (kairomone alone).
In most algal and cyanobacterial species studied, the quantum yield of photosystem II increased in response to predator fed cyanobacterium, whereas in most of these species the yield did not change in response to predator fed alga.
Also, cyanobacteria tended not to respond to a non-feeding predator. The modal qualitative responses of the electron transport rate were similar to those of the quantum yield.
To our best knowledge, the results presented here are the broadest scan of photosystem II responses in the predation context so far.
Regional Flood Frequency Analysis (RFFA) is one of the widely used approaches for estimating design floods in the ungauged basins.
We developed an eXtreme Gradient Boost (XGB) machine learning model for RFFA and flood estimation.
Our approach relies on developing a regression model between flood quantiles and the commonly available catchment descriptors.
We used CAMELs data for 671 catchments from the USA to test the approach's efficacy. The results were compared with the traditional Multiple Linear Regression methods and Artificial Neural Networks.
Results revealed that the XGB-based approach estimated design flood with the highest accuracy during training and validation with minor mean absolute error, root mean square error values, and percentage bias ranging from -10 to + 10.
The importance of each catchment feature is visualized by three different approaches Gini Impurity, Permutation, and Dropout Loss Feature Ranking. We observed that the most dominating variables are rainfall intensity, slope, snow fraction, soil porosity, and temperature. It is observed that the importance of these variables is a function of the hydroclimatic regions and varies with space.
In contrast, mean annual areal potential evapotranspiration, mean annual rainfall, fraction forest area, and soil conductivity have low significance in estimating design flood for an ungauged catchment.
Indeed, the proposed XGB-based approach has broader applicability and replicability.
Demokratiepolitik
(2024)
Der Band stellt die aktuelle Praxis der Demokratiepolitik in Bund, Ländern und Gemeinden anschaulich an zahlreichen Beispielen vor. Er will die vielfältige Demokratie der Bürger und Bürgerinnen stärken. Dabei geht es ebenso um die Praxis im Zusammenspiel von Politik, Verwaltung und Zivilgesellschaft wie um eine reflektierte Demokratiepolitik, die verschiedene Baustellen hat.
We prove that optimal lower eigenvalue estimates of Zhong-Yang type as well as a Cheng-type upper bound for the first eigenvalue hold on closed manifolds assuming only a Kato condition on the negative part of the Ricci curvature.
This generalizes all earlier results on Lp-curvature assumptions.
Moreover, we introduce the Kato condition on compact manifolds with boundary with respect to the Neumann Laplacian, leading to Harnack estimates for the Neumann heat kernel and lower bounds for all Neumann eigenvalues, which provides a first insight in handling variable Ricci curvature assumptions in this case.
Diffusive search for a static target is a common problem in statistical physics with numerous applications in chemistry and biology.
We look at this problem from a different perspective and investigate the statistics of encounters between the diffusing particle and the target. While an exact solution of this problem was recently derived in the form of a spectral expansion over the eigenbasis of the Dirichlet-to-Neumann operator, the latter is generally difficult to access for an arbitrary target.
In this paper, we present three complementary approaches to approximate the probability density of the rescaled number of encounters with a small target in a bounded confining domain. In particular, we derive a simple fully explicit approximation, which depends only on a few geometric characteristics such as the surface area and the harmonic capacity of the target, and the volume of the confining domain.
We discuss the advantages and limitations of three approaches and check their accuracy.
We also deduce an explicit approximation for the distribution of the first-crossing time, at which the number of encounters exceeds a prescribed threshold. Its relations to common first-passage time problems are discussed.
First-passage times in conical varying-width channels biased by a transverse gravitational force
(2022)
We study the crossing time statistic of diffusing point particles between the two ends of expanding and narrowing two-dimensional conical channels under a transverse external gravitational field.
The theoretical expression for the mean first-passage time for such a system is derived under the assumption that the axial diffusion in a two-dimensional channel of smoothly varying geometry can be approximately described as a one-dimensional diffusion in an entropic potential with position-dependent effective diffusivity in terms of the modified Fick-Jacobs equation.
We analyze the channel crossing dynamics in terms of the mean first-passage time, combining our analytical results with extensive two-dimensional Brownian dynamics simulations, allowing us to find the range of applicability of the one-dimensional approximation.
We find that the effective particle diffusivity decreases with increasing amplitude of the external potential.
Remarkably, the mean first-passage time for crossing the channel is shown to assume a minimum at finite values of the potential amplitude.
There is increasing evidence linking the mass-extinction event at the Cretaceous-Paleogene boundary to an asteroid impact near Chicxulub, Mexico. Here we use model simulations to explore the combined effect of sulfate aerosols, carbon dioxide and dust from the impact on the oceans and the marine biosphere in the immediate aftermath of the impact. We find a strong temperature decrease, a brief algal bloom caused by nutrients from both the deep ocean and the projectile, and moderate surface ocean acidification. Comparing the modeled longer-term post-impact warming and changes in carbon isotopes with empirical evidence points to a substantial release of carbon from the terrestrial biosphere. Overall, our results shed light on the decades to centuries after the Chicxulub impact which are difficult to resolve with proxy data.
Plain Language Summary The sudden disappearance of the dinosaurs and many other species during the end-Cretaceous mass extinction 66 million years ago marks one of the most profound events in the history of life on Earth. The impact of a large asteroid near Chicxulub, Mexico, is increasingly recognized as the trigger of this extinction, causing global darkness and a pronounced cooling. However, the links between the impact and the changes in the biosphere are not fully understood. Here, we investigate how life in the ocean reacts to the perturbations in the decades and centuries after the impact. We find a short-lived algal bloom caused by the upwelling of nutrients from the deep ocean and nutrient input from the impactor.
Previous studies suggest that associations between numbers and space are mediated by shifts of visuospatial attention along the horizontal axis. In this study, we investigated the effect of vertical shifts of overt attention, induced by optokinetic stimulation (OKS) and monitored through eye-tracking, in two tasks requiring explicit (number comparison) or implicit (parity judgment) processing of number magnitude. Participants were exposed to black-and-white stripes (OKS) that moved vertically (upward or downward) or remained static (control condition). During the OKS, participants were asked to verbally classify auditory one-digit numbers as larger/smaller than 5 (comparison task; Exp. 1) or as odd/even (parity task; Exp. 2). OKS modulated response times in both experiments. In Exp.1, upward attentional displacement decreased the Magnitude effect (slower responses for large numbers) and increased the Distance effect (slower responses for numbers close to the reference). In Exp.2, we observed a complex interaction between parity, magnitude, and OKS, indicating that downward attentional displacement slowed down responses for large odd numbers. Moreover, eye tracking analyses revealed an influence of number processing on eye movements both in Exp. 1, with eye gaze shifting downwards during the processing of small numbers as compared to large ones; and in Exp. 2, with leftward shifts after large even numbers (6,8) and rightward shifts after large odd numbers (7,9). These results provide evidence of bidirectional links between number and space and extend them to the vertical dimension. Moreover, they document the influence of visuo-spatial attention on processing of numerical magnitude, numerical distance, and parity. Together, our findings are in line with grounded and embodied accounts of numerical cognition.
Forage supply of savanna grasslands plays a crucial role for local food security and consequently, a reliable monitoring system could help to better manage vital forage resources. To help installing such a monitoring system, we investigated whether in-situ hyperspectral data could be resampled to match the spectral resolution of multi- and hyperspectral satellites; if the type of sensor affected model transfer; and if spatio-temporal patterns of forage characteristics could be related to environmental drivers. We established models for forage quantity (green biomass) and five forage quality proxies (metabolisable energy, acid/neutral detergent fibre, ash, phosphorus). Hyperspectral resolution of the Hyperion satellite mostly resulted in higher accuracies (i.e. higher R-2, lower RMSE). When applied to satellite data, though, the greater quality of the multispectral Sentinel-2 satellite data leads to more realistic forage maps. By analysing a three-year time series, we found plant phenology and cumulated precipitation to be the most important environmental drivers of forage supply. We conclude that none of the investigated satellites provide optimal conditions for monitoring purposes. Future hyperspectral satellite missions like EnMAP, combining the high information level of Hyperion with the good data quality and resolution of Sentinel-2, will provide the prerequisites for installing a regular monitoring service.
The history of the Messiah in Judaism is a history of disappointed hopes. Again and again, there were salvation fi gures to whom this role was ascribed. But redemption from occupation and foreign rule, exile, oppression and persecution failed to materialize. Therefore, the expectation of the Messiah fell to the periphery of Jewish theology. This article examinesin what ways the messianic concept plays a role in modern times and what it contributes to describing the relationship between God and humanity in Judaism. The author intends to show the development from the abandonment of a personal Messiah towards the affi rmation of the prophets’ hope for a universal messianic age in which the duty of all people to participate in the healing of the world becomes central. What becomes also clear is: The messiah idea cannot be a bridge between Christianity and Judaism.
Rhythmicity characterizes both interpersonal synchrony and spoken language. Emotions and language are forms of interpersonal communication, which interact with each other throughout development. We investigated whether and how emotional synchrony between mothers and their 9-month-old infants relates to infants' word segmentation as an early marker of language development. Twenty-six 9-month-old infants and their German-speaking mothers took part in the study. To measure emotional synchrony, we coded positive, neutral and negative emotional expressions of the mothers and their infants during a free play session. We then calculated the degree to which the mothers' and their infants' matching emotional expressions followed a predictable pattern. To measure word segmentation, we familiarized infants with auditory text passages and tested how long they looked at the screen while listening to familiar versus novel words. We found that higher levels of predictability (i.e. low entropy) during mother-infant interaction is associated with infants' word segmentation performance. These findings suggest that individual differences in word segmentation relate to the complexity and predictability of emotional expressions during mother-infant interactions.
Kein Messias in Sicht
(2024)
In You Shall Be as Gods, Erich Fromm (1900–1980) defines his position as nontheistic mysticism. This research clarifies the term, considers its importance within Fromm’s humanism, and explores its potential origins. The nontheistic mystical position plays a central role in Fromm’s understanding of the relationship between mysticism and organized religion, religion and religiosity, and it clarifies the relationship between religion, philosophy, and social psychoanalysis, whose combination constitutes his humanistic ethics. Nontheistic mysticism relates, as well, to Fromm’s understanding of human nature; it involves the question of the relationship between language, perception, and experience. The nontheistic mystical position is linked to Fromm’s negative theology, the x experience, and idolatry. Hence, the nontheistic mystical position is relevant to Fromm’s understanding of self-realization and his vision of a sane society. Unlike some scholarly opinion, the conclusions of this paper suggest that Fromm’s humanism is not radical, as long as radical is defined as an absolute atheistic secular feature that eliminates the range of religious language and experience. Rather, it is a broad and cautious humanism that, on the one hand, internalizes the transcendent divinity into the human subject and transforms it into anthropological–ethical phenomena, but, on the other, implies that atheism carries the risk of an idolatrous identification of the human being with God. Consequently, this humanism requires a religious–mystical component to adequately portray the spiritual and ethical potentials of humanity and its challenges. Nontheistic mysticism is a consciousness mechanism aimed at the fine-tuning of the individual’s moral compass, which is affected by the pathologies of normalcy that prevail in all societies.
Convolutional neural networks (CNNs) have been used for a wide range of applications in astronomy, including for the restoration of degraded images using a spatially invariant point spread function (PSF) across the field of view. Most existing development techniques use a single PSF in the deconvolution process, which is unrealistic when spatially variable PSFs are present in real observation conditions. Such conditions are simulated in this work to yield more realistic data samples. We propose a method that uses a simulated spatially variable PSF for the T80-South (T80-S) telescope, an 80-cm survey imager at Cerro Tololo (Chile). The synthetic data use real parameters from the detector noise and atmospheric seeing to recreate the T80-S observational conditions for the CNN training. The method is tested on real astronomical data from the T80-S telescope. We present the simulation and training methods, the results from real T80-S image CNN prediction, and a comparison with space observatory Gaia. A CNN can fix optical aberrations, which include image distortion, PSF size and profile, and the field position variation while preserving the source's flux. The proposed restoration approach can be applied to other optical systems and to post-process adaptive optics static residual aberrations in large-diameter telescopes.
This longitudinal study aimed to investigate how motivational transitions of adolescents in the domain of mathematics from Grades 9 to 10 were related to student-perceived mathematics teacher support and student -oriented teaching. Data were drawn from the 2012 Programme for International Student Assessment (PISA) and its German national extension called PISA Plus 2012-2013. We used a subsample of 2605 students (51.0 % girls) from 198 classrooms. Using latent profile analyses, we identified three motivational patterns based on expectancy-value theory that were meaningfully associated with students' mathematics test scores and work ethics. Latent transition analyses showed that these patterns were mostly stable across time. Occurring changes were characterized by a decrease in mathematics motivation across time. Student-oriented teaching as reported by students in Grade 9 impeded maladaptive motivational transitions. Students with particularly low interest and utility value benefitted from teachers who direct their instruction at students' motivational characteristics.
Purpose: Coarticulatory effects in speech vary across development, but the sources of this variation remain unclear. This study investigated whether developmental differences in intrasyllabic coarticulation degree could be explained by differences in children's articulatory patterns compared to adults.
Method: To address this question, we first compared the tongue configurations of 3-to 7-year-old German children to those of adults. The observed developmental differences were then examined through simulations with Task Dynamics Application, a Task Dynamics simulation system, to establish which articulatory modifications could best reproduce the empirical results. To generate syllables simulating the lack of tongue gesture differentiation, we tested three simulation scenarios.
Results: We found that younger speakers use less differentiated articulatory patterns to achieve alveolar constrictions than adults. The simulations corresponding to undifferentiated control of tongue tip and tongue body resulted in (a) tongue shapes similar to those observed in natural speech and (b) higher degrees of intrasyllabic coarticulation in children when compared to adults.
Conclusions: Results provide evidence that differences in articulatory patterns contribute to developmental differences in coarticulation degree. This study further shows that empirically informed modeling can advance our understanding of changes in coarticulatory patterns across age.
The article explores the philosophical exegesis in Obadiah Sforno's sixteenth-century Psalms commentary and its reception in Berlin of the late eighteenth century, where it was reprinted in the Haskalah's biggest bestseller-an edition of Moses Mendelssohn's Psalms translation with Hebrew commentary.
While the inclusion of entire commentaries by earlier exegetes was unique among all Haskalah Bible editions, I argue that the choice to include Sforno's commentary alongside Mendelssohn's translation of Psalms, itself an expression of Mendelssohn's political-theological defense of Judaism, was intended to buttress shared philosophical doctrines and concepts located by the two scholars in Psalms, notwithstanding temporal and cultural divergences: imitatio Dei, the salvation of the individual soul, and Israel's eternity.
In this work, we present a comprehensive evaluation of a stochastic multi-site, multi-variate weather generator at the scale of entire Germany and parts of the neighbouring countries covering the major German river basins Elbe, Upper Danube, Rhine, Weser and Ems with a total area of approximately 580,000 km(2). The regional weather generator, which is based on a first-order multi-variate auto-regressive model, is setup using 53-year long daily observational data at 528 locations. The performance is evaluated by investigating the ability of the weather generator to replicate various important statistical properties of the observed variables including precipitation occurrence and dry/wet transition probabilities, mean daily and extreme precipitation, multi-day precipitation sums, spatial correlation structure, areal precipitation, mean daily and extreme temperature and solar radiation. We explore two marginal distributions for daily precipitation amount: mixed Gamma-Generalized Pareto and extended Generalized Pareto. Furthermore, we introduce a new procedure to estimate the spatial correlation matrix and model mean daily temperature and solar radiation. The extensive evaluation reveals that the weather generator is greatly capable of capturing most of the crucial properties of the weather variables, particularly of extreme precipitation at individual locations. Some deficiencies are detected in capturing spatial precipitation correlation structure that leads to an overestimation of areal precipitation extremes. Further improvement of the spatial correlation structure is envisaged for future research. The mixed marginal model found to outperform the extended Generalized Pareto in our case. The use of power transformation in combination with normal distribution significantly improves the performance for non-precipitation variables. The weather generator can be used to generate synthetic event footprints for large-scale trans-basin flood risk assessment.
More than 30 years have passed since Mehler et al. (1988) proposed that newborns can discriminate between languages that belong to different rhythm classes: stress-, syllable- or mora-timed. Thereupon they developed the hypothesis that infants are sensitive to differences in vowel and consonant interval durations as acoustic correlates of rhythm classes. It remains unknown exactly which durational computations infants use when perceiving speech for the purposes of distinguishing languages. Here, a meta-analysis of studies on infants' language discrimination skills over the first year of life was conducted, aiming to quantify how language discrimination skills change with age and are modulated by rhythm classes or durational metrics. A systematic literature search identified 42 studies that tested infants' (birth to 12 months) discrimination or preference of two language varieties, by presenting infants with auditory or audio-visual continuous speech. Quantitative data synthesis was conducted using multivariate random effects meta-analytic models with the factors rhythm class difference, age, stimulus manipulation, method, and metrics operationalising proportions of and variability in vowel and consonant interval durations, to explore which factors best account for language discrimination or preference. Results revealed that smaller differences in vowel interval variability (oV) and larger differences in successive consonantal interval variability (rPVI-C) were associated with more successful language discrimination, and better accounted for discrimination results than the factor rhythm class. There were no effects of age for discrimination but results on preference studies were affected by age: the older infants get, the more they prefer non-native languages that are rhythmically similar to their native language, but not non-native languages that are rhythmically distinct. These findings can inform theories on language discrimination that have previously focussed on rhythm class, by providing a novel way to operationalise rhythm in language in the extent to which it accounts for infants' language discrimination abilities.
Temperature is an important factor governing microbe-mediated carbon feedback from permafrost soils. The link between taxonomic and functional microbial responses to temperature change remains elusive due to the lack of studies assessing both aspects of microbial ecology. Our previous study reported microbial metabolic and trophic shifts in response to short-term temperature increases in Arctic peat soil, and linked these shifts to higher CH4 and CO2 production rates (Proceedings of the National Academy of Sciences of the United States of America, 112, E2507-E2516). Here, we studied the taxonomic composition and functional potential of samples from the same experiment. We see that along a high-resolution temperature gradient (1-30 degrees C), microbial communities change discretely, but not continuously or stochastically, in response to rising temperatures. The taxonomic variability may thus in part reflect the varied temperature responses of individual taxa and the competition between these taxa for resources. These taxonomic responses contrast the stable functional potential (metagenomic-based) across all temperatures or the previously observed metabolic or trophic shifts at key temperatures. Furthermore, with rising temperatures we observed a progressive decrease in species diversity (Shannon Index) and increased dispersion of greenhouse gas (GHG) production rates. We conclude that the taxonomic variation is decoupled from both the functional potential of the community and the previously observed temperature-dependent changes in microbial function. However, the reduced diversity at higher temperatures might help explain the higher variability in GHG production at higher temperatures.
Trade-offs between traits are present across different levels of biological systems and ultimately reflect constraints imposed by physicochemical laws and the structure of underlying biochemical networks. Yet, mechanistic explanation of how trade-offs between molecular traits arise and how they relate to optimization of fitness-related traits remains elusive. Here, we introduce the concept of relative flux trade-offs and propose a constraint-based approach, termed FluTOr, to identify metabolic reactions whose fluxes are in relative trade-off with respect to an optimized fitness-related cellular task, like growth. We then employed FluTOr to identify relative flux trade-offs in the genome-scale metabolic networks of Escherichia coli, Saccharomyces cerevisiae, and Arabidopsis thaliana. For the metabolic models of E. coli and S. cerevisiae we showed that: (i) the identified relative flux trade-offs depend on the carbon source used and that (ii) reactions that participated in relative trade-offs in both species were implicated in cofactor biosynthesis. In contrast to the two microorganisms, the relative flux trade-offs for the metabolic model of A. thaliana did not depend on the available nitrogen sources, reflecting the differences in the underlying metabolic network as well as the considered environments. Lastly, the established connection between relative flux trade-offs allowed us to identify overexpression targets that can be used to optimize fitness-related traits. Altogether, our computational approach and findings demonstrate how relative flux trade-offs can shape optimization of metabolic tasks, important in biotechnological applications.
Formal constraints on crossing dependencies have played a large role in research on the formal complexity of natural language grammars and parsing. Here we ask whether the apparent evidence for constraints on crossing dependencies in treebanks might arise because of independent constraints on trees, such as low arity and dependency length minimization. We address this question using two sets of experiments. In Experiment 1, we compare the distribution of formal properties of crossing dependencies, such as gap degree, between real trees and baseline trees matched for rate of crossing dependencies and various other properties. In Experiment 2, we model whether two dependencies cross, given certain psycholinguistic properties of the dependencies. We find surprisingly weak evidence for constraints originating from the mild context-sensitivity literature (gap degree and well-nestedness) beyond what can be explained by constraints on rate of crossing dependencies, topological properties of the trees, and dependency length. However, measures that have emerged from the parsing literature (e.g., edge degree, end-point crossings, and heads' depth difference) differ strongly between real and random trees. Modeling results show that cognitive metrics relating to information locality and working-memory limitations affect whether two dependencies cross or not, but they do not fully explain the distribution of crossing dependencies in natural languages. Together these results suggest that crossing constraints are better characterized by processing pressures than by mildly context-sensitive constraints.
Innate or acquired?
(2021)
In this chapter, some of the findings from sociolinguistic interviews with 25 speakers of Indian English and 26 speakers of Nigerian English are presented. Emanating from a larger research project concerned with conceptualizations of gender, the current analysis focuses on conceptualizations of homosexuality and makes use of the analytical tools provided by Cultural Linguistics and Cognitive Sociolinguistics. In particular, the notions of “cultural conceptualizations” (e.g., Sharifian, 2011, 2017) and “cultural model” (e.g., Wolf & Polzenhagen, 2009; also cf. Schneider, 2014) are addressed.
At the time of data collection, discriminatory legislation concerning homosexuality was in force in India and Nigeria. Opinion polls likewise echoed a negative stance towards homosexuality among the population of the two countries. This raised the expectation that similar conceptualizations of homosexuality might be found in Indian and Nigerian English, both in terms of their negative connotation and of how homosexuality would exactly be conceptualized. However, this expectation was not fulfilled. Firstly, the acceptance among the Indian participants to this study was generally greater. Secondly, homosexuality was predominantly conceptualized as an innate condition in the Indian English data, while it was prevalently understood as an acquired condition by the Nigerian informants. Drawing from earlier findings within the context of the same project (Finzel, 2021; fc.), I suggest that these differences can be explained with culture-specific models of gender that lend their logic to conceptualizations of homosexuality.
Развитие науки, общества и медицины ведет за собой неуклонный рост средней продолжительности жизни. В результате наука сталкивается с новыми задачами, в число которых входит предотвращение деменции и поддержание эффективной работоспособности мозга при старении человека. Одним из защитных факторов, предотвращающих ослабление когнитивных функций и поддерживающих нейропластичность мозга, является билингвизм.
Однако дебаты насчет нейропротекторных свойств двуязычия до сих пор являются актуальными. В данной статье рассмотрен феномен нейрокогнитивного резерва (НКР) и определена взаимосвязь между билингвизмом и такими составляющими НКР, как мозговой резерв, нейрональный резерв и нейрональная компенсация.
Кроме этого, в статье приведен обзор исследований, посвященных изучению нейронных и когнитивных механизмов влияния билингвизма на здоровое функционирование мозга при старении. В заключении мы вкратце остановились на том, каким образом двуязычие может защищать мозг от старения благодаря взаимодействию между мозговыми и когнитивными составляющими НКР.
Most, if not all, of the studies in Cultural Linguistics have (a) taken a synchronic perspective or (b) focused on specific, intracultural conceptualizations. In my chapter, I will look at a cluster of conceptualizations that have been found to exist in different historical periods, in different languages and varieties, and on different continents. The case in point is conceptualizations of magical practices based on menstrual blood. The existence of these conceptualizations across time and space raises the challenging questions of their motivation, and, more generally, the “flow of conceptualizations.” While these questions will be pursued in my chapter, the main focus will be on an elaboration of the conceptual network of conceptualizations pertaining to menstrual blood magic.
Microbiomes have an immense potential to enhance plant resilience to various biotic and abiotic stresses. However, intrinsic microbial communities respond to changes in their host's physiology and environment during plant's life cycle. The potential of the inherent plant microbiome has been neglected for a long time, especially for the postharvest period. Currently, close to 50% of all produced fruits and vegetables are lost either during production or storage. Biological control of spoilage and storage diseases is still lacking sufficiency. Today, novel multiomics technologies allow us to study the microbiome and its responses on a community level, which will help to advance current classic approaches and develop more effective and robust microbiome-based solutions for fruit and vegetable storability, quality, and safety.
Otter shrew mitogenomes (Afrotheria, Potamogalidae) reconstructed from historical museum skins
(2022)
African otter shrews (Potamogalidae) are Afrotherian mammals adapted to a semi-aquatic lifestyle. Given their rareness, genetic data on otter shrews are limited. By applying laboratory methods tuned for the recovery of archival DNA and an iterative mapping approach, we reconstructed whole mitochondrial genomes of the Giant (Potamogale velox) and Ruwenzori pygmy otter shrew (Micropotamogale ruwenzorii) from historical museum skins. Phylogenetic analyses are consistent with previous reports in recovering a sister relationship between African otter shrews and Malagasy tenrecs. The long branches separating both lineages, however, support their recognition as separate families.
Critical role of parasite-mediated energy pathway on community response to nutrient enrichment
(2022)
Parasites form an integral part of food webs, however, they are often ignored in classic food web theory or limited to the investigation of trophic transmission pathways. Specifically, direct consumption of parasites by nonhost predators is rarely considered, while it can contribute substantially to energy flow in food webs. In aquatic systems, chytrids constitute a major group of fungal parasites whose free-living infective stages (zoospores) form a highly nutritional food source to zooplankton. Thereby, the consumption of zoospores can create an energy pathway from otherwise inedible phytoplankton to zooplankton ( "mycoloop "). This parasite-mediated energy pathway might be of special importance during phytoplankton blooms dominated by inedible or toxic primary producers like cyanobacteria, which are on the rise with eutrophication and global warming. We theoretically investigated community dynamics and energy transfer in a food web consisting of an edible nonhost and an inedible host phytoplankton species, a parasitic fungus, and a zooplankton species grazing on edible phytoplankton and fungi. Food web dynamics were investigated along a nutrient gradient contrasting nonadaptive zooplankton species representative for filter feeders like cladocerans and zooplankton with the ability to actively adapt their feeding preferences like many copepod species. Overall, the importance of the mycoloop for zooplankton increases with nutrient availability. This increase is smooth for nonadaptive consumers. For adaptive consumers, we observe an abrupt shift from an almost exclusive preference for edible phytoplankton at low nutrient levels to a strong preference for parasitic fungi at high nutrient levels. The model predicts that parasitic fungi could contribute up to 50% of the zooplankton diet in nutrient-rich environments, which agrees with empirical observations on zooplankton gut content from eutrophic systems during blooms of inedible diatoms or cyanobacteria. Our findings highlight the role of parasite-mediated energy pathways for predictions of energy flow and community composition under current and future environmental change.
Ethik-Komitees gehören zum festen Bestandteil des Ethikmanagements und der Organisationsethik in klinischen Einrichtungen des Gesundheitswesens. Entsprechende Ethikstrukturen und die damit verbundenen Angebote stoßen hinsichtlich ihrer Wirksamkeit allerdings an ihre Grenzen. Ihre Arbeitsweisen sind häufig reaktiv und eine Verankerung in den entsprechenden Organisationsebenen fehlt. Ausgehend von diesen Limitationen der klinischen Ethikberatung hat sich die multiprofessionelle „Arbeitsgruppe Ethik“ am Universitätsklinikum Tübingen (UKT) um die Konzeption und Implementierung eines neuen Ansatzes zur nachhaltigen Integration von ethischen Reflexions- und Entscheidungsprozessen auf den Stationen des UKT bemüht. Mit dem Tübinger Modell der Ethikbeauftragten der Station verfolgt sie ein Pilotprojekt, das speziell geschulte Pflegekräfte aus allen Stationen des UKT als AnsprechpartnerInnen für ethische Fragen einsetzt. Damit stellen die Ethikbeauftragten eine Erweiterung zu etablierten Strukturen der Ethikberatung dar und ergänzen vorhandene Top-Down-Strategien. Der vorliegende Beitrag stellt die Zielsetzungen des Tübinger Modells dar und schildert erste Erfahrungen in der Umsetzung. Neben der Einbettung in organisationale Strukturen der Ethikberatung werden die stationsinternen und stationsübergreifenden Aufgaben der Ethikbeauftragten dargestellt. Zudem wird das Qualifikationsprogramm für Ethikbeauftragte (Basis- und Aufbauschulung) sowie ein Train-the-Trainer-Konzept vorgestellt, welche eine vertiefende Entwicklung von pflege- und medizinethischer Kompetenzen unterstützen und Sicherheit in den stationsbezogenen Reflexions- und Entscheidungsprozessen vermitteln.
Multi-species biofilms are more resistant against stress compared to single-species biofilms. However, the mechanisms underlying this common observation remain elusive. Therefore, we studied biofilm formation of well-known opportunistic pathogens (Acinetobacter baumanii, Enterococcus faecium, Escherichia coli, Staphylococcus haemolyticus and Stenotrophomonas maltophilia) in various approaches. Synergistic effects in their multi species biofilms were observed. Using metatranscriptomics, changes in the gene expression of the involved members became evident, and provided explanations for the improved survivability under nutrient limitation and exposure to disinfectants. Genes encoding proteins for vitamin B6 synthesis and iron uptake were linked to synergism in the multi-species biofilm under nutrient-limited conditions. Our study indicates that sub-lethal concentrations of an alcohol-based disinfectant enhance biofilm yields in multi-species assemblages. A reduction of the dominant taxa in the multi-species biofilm under disinfectant pressure allowed minor taxa to bloom. The findings underline the importance of minor but antimicrobial-resistant species that serve as "protectors" for the whole assemblage due to upregulation of genes involved in defence mechanisms and biofilm formation. This ultimately results in an increase in the total yield of the multi-species biofilm. We conclude that inter-species interactions may be crucial for the survival of opportunistic pathogens; especially under conditions that are typically found under hospital settings.
The acquisition of clitics still remains a highly controversial issue in Greek acquisition literature despite the bulk of studies performed.
Object clitics have been shown to be early acquired by monolingual children in terms of production rates, whereas only highly proficient bilingual children achieve target-like performance.
Crucially, errors in gender marking are persistent for monolingual and bilingual children even when adult-like production rates are achieved.
This study aims to readdress the acquisition of clitics in an innovative way, by entering the variable of gender in an experimental design targeting to assess production and processing by bilingual and monolingual children.
Moreover, we examined the role of language proficiency (in terms of general verbal intelligence and syntactic production abilities). The groups had comparable performance in both tasks (in terms of correct responses and error distribution in production and reaction times in comprehension).
However, verbal intelligence had an effect on the performance of the monolingual but not of the bilingual group in the production task, and bilingual children were overall slower in the comprehension task. Syntactic production abilities did not have any effect. We argue that gender marking affects clitic processing, and we discuss the implications of our findings for bilingual acquisition.
A marine sediment record from the central Bering Sea, spanning the last 20 thousand years (ka), was studied to unravel the depositional history with regard to terrigenous sediment supply and biogenic sedimentation. Methodic approaches comprised the inference of accumulation rates of siliciclastic and biogenic components, grain-size analysis, and (clay) mineralogy, as well as paleoclimatic modelling. Changes in the depositional history provides insight into land-ocean linkages of paleoenvironmental changes. During the finale of the Last Glacial Maximum, the depositional environment was characterized by hemipelagic background sedimentation. A marked change in the terrigenous sediment provenance during the late Heinrich 1 Stadial (15.7-14.5 ka), indicated by increases in kaolinite and a high glaciofluvial influx of clay, gives evidence of the deglaciation of the Brooks Range in the hinterland of Alaska. This meltwater pulse also stimulated the postglacial onset of biological productivity. Glacial melt implies regional climate warming during a time of widespread cooling on the northern hemisphere. Our simulation experiment with a coupled climate model suggests atmospheric teleconnections to the North Atlantic, with impacts on the dynamics of the Aleutian Low system that gave rise to warmer winters and an early onset of spring during that time. The late deglacial period between 14.5 and 11.0 ka was characterized by enhanced fluvial runoff and biological productivity in the course of climate amelioration, sea-level rise, seasonal sea-ice retreat, and permafrost thaw in the hinterland. The latter processes temporarily stalled during the Younger Dryas stadial (12.9-11.7 ka) and commenced again during the Preboreal (earliest Holocene), after 11.7 ka. High river runoff might have fertilized the Bering Sea and contributed to enhanced upper ocean stratification. Since 11.0 ka, advanced transgression has shifted the coast line and fluvial influence of the Yukon River away from the study site. The opening of the Bering Strait strengthened contour currents along the continental slope, leaving behind winnowed sand-rich sediments through the early to mid-Holocene, with non-deposition occurring since about 6.0 ka.
Rapid humidity changes across the Northern South China Sea during the last similar to 40 kyrs
(2021)
A key aspect of East Asian climate is its summer monsoonal system which influences nearly one-third of the world's population. Recent results indicate that the primary response of the East Asian summer monsoon (EASM) to anthropogenic forced climate warming may be a shift in geographical range instead of an intensity change, which would lead to spatial coexistence of floods and droughts over southeastern Asia. The predicted EASM variability in the future has made it paramount to study its past changes and the associated tempo-spatial pattern of aridity and humidity in its purview. In order to decipher past changes in EASM, we applied a multi-proxy geochemical approach to the sediment core ORI-891-16-P1 located in the northern South China Sea. The position of this sediment core on top of a seamount makes it uniquely sensitive to changes in the terrigenous input into northern South China Sea unbiased by sea level-induced downslope transport processes. Utilizing the ln(Ti/Ca) ratio throughout the sediment sequence we trace terrigenous influx changes reflecting EASM prevalence during the last similar to 40 kyrs. Based on the comparison of our results to previous studies we infer that the Last Glacial Maximum (LGM; similar to 20 ka BP) was characterized by a steep N-S humidity gradient. This spatial pattern was in line with a southward shift or contraction of the summer monsoonal trough of 10-15 degrees from its current position toward the centre of the South China Sea. Superimposed on orbital time scale fluctuations we also find strong indication of millennial-scale variability related to Heinrich Stadials. The impact of Heinrich Stadials on the EASM seems amplified during insolation minima, while high summer insolation seems to buffer the monsoonal system to such perturbations. We infer that (i) the humidity-aridity distribution during the LGM mimics predictions of the proposed future EASM configuration, and (ii) that the sensitivity of the EASM to weakening in the Atlantic Meridional Overturning Circulation is the strongest since the last glacial.
We consider the synchrotron emission from electrons out in the Galactic halo bubble region where the Fermi bubble structures reside.
Utilizing a simple analytical expression for the non-thermal electron distribution and a toy magnetic field model, we simulate polarized synchrotron emission maps at a frequency of 30 GHz.
Comparing these maps with the observational data, we obtain constraints on the parameters of our toy Galactic halo bubble magnetic field model.
Utilizing this parameter value range for the toy magnetic field model, we determine the corresponding range of arrival directions and suppression factors of ultra high energy cosmic rays (UHECRs) from potential local source locations.
We find that high levels of flux suppression (down to 2 per cent) and large deflection angles (>= 80 degrees) are possible for source locations whose line of sight pass through the Galactic halo bubble region.
We conclude that the magnetic field out in the Galactic halo bubble region can strongly dominate the level of deflection UHECRs experience whilst propagating from local sources to Earth.
Large agricultural streams receive excessive inputs of nitrogen.
However, quantifying the role of these streams in nitrogen processing remains limited because continuous direct measurements of the interacting and highly time-varying nitrogen processing pathways in larger streams and rivers are very complex.
Therefore, we employed a monitoring-driven modelling approach with high-frequency in situ data and the river water quality model Water Quality Analysis Simulation Program (WASP) 7.5.2 in the 27.4 km reach of the sixth-order agricultural stream called Lower Bode (central Germany) for a 5-year period (2014-2018).
Paired high-frequency sensor data (15 min interval) of discharge, nitrate, dissolved oxygen, and chlorophyll a at upstream and downstream stations were used as model boundaries and for setting model constraints.
The WASP model simulated 15 min intervals of discharge, nitrate, and dissolved oxygen with Nash-Sutcliffe efficiency values higher than 0.9 for calibration and validation, enabling the calculation of gross and net dissolved inorganic nitrogen uptake and pathway rates on a daily, seasonal, and multiannual scale.
Results showed daily net uptake rate of dissolved inorganic nitrogen ranged from -17.4 to 553.9 mgNm(-2)d(-1). The highest daily net uptake could reach almost 30 % of the total input loading, which occurred at extreme low flow in summer 2018.
The growing season (spring and summer) accounted for 91 % of the average net annual uptake of dissolved inorganic nitrogen in the measured period. In spring, both the DIN gross and net uptake were dominated by the phytoplankton uptake pathway. In summer, benthic algae assimilation dominated the gross uptake of dissolved inorganic nitrogen.
Conversely, the reach became a net source of dissolved inorganic nitrogen with negative daily net uptake values in autumn and winter, mainly because the release from benthic algae surpassed uptake processes.
Over the 5 years, average gross and net uptake rates of dissolved inorganic nitrogen were 124.1 and 56.8 mgNm(-2)d(-1), which accounted for only 2.7 % and 1.2 % of the total loadings in the Lower Bode, respectively. The 5-year average gross DIN uptake decreased from assimilation by benthic algae through assimilation by phytoplankton to denitrification.
Our study highlights the value of combining river water quality modelling with high-frequency data to obtain a reliable budget of instream dissolved inorganic nitrogen processing which facilitates our ability to manage nitrogen in aquatic systems.
This study provides a methodology that can be applied to any large stream to quantify nitrogen processing pathway dynamics and complete our understanding of nitrogen cycling.
Temperature impacts on hate speech online: evidence from 4 billion geolocated tweets from the USA
(2022)
Background - A link between weather and aggression in the offline world has been established across a variety of societal settings. Simultaneously, the rapid digitalisation of nearly every aspect of everyday life has led to a high frequency of interpersonal conflicts online. Hate speech online has become a prevalent problem that has been shown to aggravate mental health conditions, especially among young people and marginalised groups.
We examine the effect of temperature on the occurrence of hate speech on the social media platform Twitter and interpret the results in the context of the interlinkage between climate change, human behaviour, and mental health.
Methods - In this quantitative empirical study, we used a supervised machine learning approach to identify hate speech in a dataset containing around 4 billion geolocated tweets from 773 cities across the USA between May 1, 2014 and May 1, 2020.
We statistically evaluated the changes in daily hate tweets against changes in local temperature, isolating the temperature influence from confounding factors using binned panel-regression models.
Findings - The prevalence of hate tweets was lowest at moderate temperatures (12 to 21?) and marked increases in the number of hate tweets were observed at hotter and colder temperatures, reaching up to 12middot5% (95% CI 8middot0-16middot5) for cold temperature extremes (-6 to -3?) and up to 22middot0% (95% CI 20middot5-23middot5) for hot temperature extremes (42 to 45?). Outside of the moderate temperature range, the hate tweets also increased as a proportion of total tweeting activity. The quasi-quadratic shape of the temperature-hate tweet curve was robust across varying climate zones, income quartiles, religious and political beliefs, and both city-level and state-level aggregations.
However, temperature ranges with the lowest prevalence of hate tweets were centred around the local temperature mean and the magnitude of the increases in hate tweets for hot and cold temperatures varied across the climate zones.
Interpretation - Our results highlight hate speech online as a potential channel through which temperature alters interpersonal conflict and societal aggression. We provide empirical evidence that hot and cold temperatures can aggravate aggressive tendencies online. The prevalence of the results across climatic and socioeconomic subgroups points to limitations in the ability of humans to adapt to temperature extremes.
Soil microbial communities are crucial for plant growth and are already depleted by anthropogenic activities.
The application of microbial transplants provides a strategy to restore beneficial soil traits, but less is known about the microbiota of traditional inoculants used in biodynamic agriculture.
In this study, we used amplicon sequencing and quantitative PCR to decipher microbial communities of composts, biodynamic manures, and plant preparations from Austria and France.
In addition, we investigated the effect of extracts derived from biodynamic manure and compost on the rhizosphere microbiome of apple trees. Microbiota abundance, composition, and diversity of biodynamic manures, plant preparations, and composts were distinct. Microbial abundances ranged between 1010-1011 (bacterial 16S rRNA genes) and 109-1011 (fungal ITS genes). The bacterial diversity was significantly higher in biodynamic manures compared to compost without discernible differences in abundance. Fungal diversity was not significantly different while abundance was increased in biodynamic manures. The microbial communities of biodynamic manures and plant preparations were specific for each production site, but all contain potentially plant-beneficial bacterial genera.
When applied in apple orchards, biodynamic preparations (extracts) had the non-significant effect of reducing bacterial and fungal abundance in apple rhizosphere (4 months post-application), while increasing fungal and lowering bacterial Shannon diversity.
One to four months after inoculation, individual taxa indicated differential abundance. We observed the reduction of the pathogenic fungus Alternaria, and the enrichment of potentially beneficial bacterial genera such as Pseudomonas.
Our study paves way for the science-based adaptation of empirically developed biodynamic formulations under different farming practices to restore the vitality of agricultural soils.
Das Erbe der Aufklärung
(2024)