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Dieser Band der Schriftenreihe der Badischen Heimat will im Rahmen der Vielzahl von Publikationen, die in diesem Jahr an den Beginn des Ersten Weltkrieges erinnern, einen besonderen Beitrag leisten. Gleichsam als „Geschichte von unten“ wirkend, gibt die vorliegende Sammlung der Feldpostbriefe einen gefilterten Eindruck in das Seelenleben der Kriegsgeneration wieder. Sie ist als Kollektion badischer Soldatenbriefe in dieser Form bisher einmalig und erweitert das Wahrnehmungsspektrum der scheinbar in weiter Ferne und dennoch so nah liegenden „Urkatastrophe“ um eine weitere wichtige Nuance.
Individualistische Ansätze können die sozialen Dynamiken terroristischen Handelns nur unzureichend erklären, da sie keine Terrorismusanalysen, sondern Analysen von Terroristen liefern. Der Aufsatz geht deshalb von Georg Simmels formaler Analyse der „Geheimen Gesellschaft“ aus und entwickelt auf dieser Grundlage eine soziologische Erklärung dafür, wie die sozialen Beziehungen innerhalb solcher Gruppierungen die Opportunitätsstrukturen ihrer Mitglieder so strukturieren, dass ein Handeln entsteht, das wir als terroristisch bezeichnen können.
Schließung, soziale
(2014)
Von Ulfila bis Rekkared
(2014)
Für etwa 200 Jahre, vom Ende des 4. Jahrhunderts bis 589 n. Chr., gehören die Westgoten einem von der Orthodoxie der Reichskirche abweichenden christlichen Bekenntnis an. Auf dem 3. Konzil von Toledo beendet König Rekkared diesen Zustand religiöser Alterität durch die Konversion zum Katholizismus. Die antiken Berichte zeichnen nur vordergründig ein kohärentes Bild des Christentums der Goten. Dagegen weist Eike Faber Widersprüche und Fehler in der Überlieferung nach und bietet eine Reihe neuer Interpretationen an. Die genauere Betrachtung vermag dabei sowohl den dogmatischen Gehalt des Christentums der Goten schärfer zu konturieren als auch die Beweggründe für die Annahme des neuen Glaubens herauszustellen und die traditionelle Datierung dieses Vorgangs zu widerlegen. Schließlich wird deutlich, welche Funktion das fortgesetzte Festhalten an einer demonstrativ anderen religiösen Überzeugung für die Goten hatte. Prägnante Wegmarken der gotischen Geschichte, wie die Bibelübersetzung Ulfilas, die Eroberung und Plünderung Roms 410 n. Chr. oder die demonstrative Aufgabe der religiösen Differenz durch König Rekkared, werden erst durch diesen neuen, umfassenden Kontext verständlich.
Experiment Unterricht
(2014)
„Nur der Freiheit …“?
(2014)
Einleitung
(2014)
Im Jahr 2013 jährte sich zum 100. Mal der „Freideutsche Jugendtag“ auf dem Hohen Meißner. Am Rande dieses historischen Treffens, das als erste große Manifestation der „Deutschen Jugendbewegung“ gilt, kam es zu antisemitischen Ausfällen. In der Folge entstand erstmals ein „völkischer Flügel“ der Jugendbewegung. Nach dem Ersten Weltkrieg gerieten weite Teile der Jugendbewegung, die sich nun als „Bündische Jugend“ begriff, in nationalistisches Fahrwasser und ließen sich für rechtsextreme Politik mobilisieren. 1933 in die Illegalität gezwungen, wandte sich die Mehrheit der seit 1945 wieder- oder neubegründeten Bünde und Verbände zwar der demokratischen Gesellschaft zu, rechtsextreme Jugendgruppen und Publizisten versuchten aber wiederholt, das jugendbewegte Erbe zu vereinnahmen. Der Sammelband wird das Spannungsfeld zwischen Jugendbewegung, Nationalismus und Antisemitismus ausleuchten, wobei erstmals auch jüngere bis jüngste Erscheinungen in den Blick genommen werden.
Biosensors for the detection of benzaldehyde and g-aminobutyric acid (GABA) are reported using aldehyde oxidoreductase PaoABC from Escherichia coli immobilized in a polymer containing bound low potential osmium redox complexes. The electrically connected enzyme already electrooxidizes benzaldehyde at potentials below −0.15 V (vs. Ag|AgCl, 1 M KCl). The pH-dependence of benzaldehyde oxidation can be strongly influenced by the ionic strength. The effect is similar with the soluble osmium redox complex and therefore indicates a clear electrostatic effect on the bioelectrocatalytic efficiency of PaoABC in the osmium containing redox polymer. At lower ionic strength, the pH-optimum is high and can be switched to low pH-values at high ionic strength. This offers biosensing at high and low pH-values. A “reagentless” biosensor has been formed with enzyme wired onto a screen-printed electrode in a flow cell device. The response time to addition of benzaldehyde is 30 s, and the measuring range is between 10–150 µM and the detection limit of 5 µM (signal to noise ratio 3:1) of benzaldehyde. The relative standard deviation in a series (n = 13) for 200 µM benzaldehyde is 1.9%. For the biosensor, a response to succinic semialdehyde was also identified. Based on this response and the ability to work at high pH a biosensor for GABA is proposed by coimmobilizing GABA-aminotransferase (GABA-T) and PaoABC in the osmium containing redox polymer.
'Mitfühlend sprechen'
(2014)
Im Zentrum dieser interaktional-linguistischen Untersuchung steht die Frage, welchen Beitrag die prosodisch-phonetische Gestaltung einer Äußerung zu ihrer Interpretation als Darstellung von Empathie leistet. Dem liegt eine interaktionale Auffassung von Empathie zu Grunde: Empathie wird nicht als psychoemotionaler Zustand konzeptualisiert, sondern als Darstellung von Verstehen/ Verständnis/ Mitgefühl/ Mitleid in sozialer Interaktion. Gegenstand der Untersuchung ist die interaktive Bearbeitung persönlicher Erlebnisse in deutschen Alltagsgesprächen. Es wird gezeigt, dass – an spezifischen sequentiellen Positionen – Kombinationen folgender prosodisch-phonetischer Ressourcen potenziell relevant sind, um Äußerungen als empathisch, hier i.S.v. 'mitfühlend', interpretierbar zu machen: geringere und/ oder abnehmende Lautstärke/ Diminuendo, tiefes Tonhöhenregister, flach auslaufende Kontur, Behauchung, Knarrstimme, geringe Sprechspannung/ weiche Artikulation, Silbendehnung, Lippenrundung, rhythmische Integration/ Legato-Rhythmus.
Phonetik und Prosodie werden seit langem als fundamentale Aspekte des gesprochenen Diskurses behandelt. Insbesondere Prosodie und Phonetik natürlicher Alltagssprache haben sich zu einem eigenen Forschungsbereich entwickelt. Das Hauptaugenmerk lag dabei bisher auf Gesprächstruktur, Turn-Taking und die Kontextualisierung von sozialen Praktiken, Handlungen, Genres, Stilen und Affekten.
Dieser Band präsentiert sowohl eine Einführung in Grundbegriffe und -konzepte der prosodisch-phonetischen Gesprächsforschung, als auch neue Befunde junger und etablierter ForscherInnen. Die einzelnen Kapitel behandeln unter anderem Prosodie und Phonetik von Affektdarstellungen, Theatervorstellungen, institutioneller Interaktion und Sequenzorganisation. Gleichzeitig bietet der Band einen Überblick über die Methoden, die in diesem Forschungsbereich genutzt werden. Der Band richtet sich damit an alle, für deren Arbeit die Erforschung von Sprache und Interaktion eine Rolle spielt, seien es Studierende oder erfahrene ForscherInnen.
This paper reports a problematic case of unequivocally evidencing participant orientation to the projective force of some turn-initial demonstrative wh-clefts (DCs) within the framework of Conversation Analysis (CA) and Interactional Linguistics (IL). Conducting rhythmic analyses appears helpful in this regard, in that they disclose rhythmic regularities which suggest a speaker's orientation towards a projected turn continuation. In this particular case, rhythmic analyses can therefore be shown to meaningfully complement sequential analyses and analyses of turn-design, so as to gather additional evidence for participant orientations. In conclusion, I will point to possibly more extensive relations between rhythmicity and projection and proffer a tentative outlook for the usability of rhythmic analyses as an analytic tool in CA and IL.
A key problem in automatic annotation of historical corpora is inconsistent spelling. Because the spelling of some word forms can differ between texts, a language model trained on already annotated treebanks may fail to recognize known word forms due to differences in spelling. In the present work, we explore the feasibility of an unsupervised method for spelling-adjustment for the purpose of improved part of speech (POS) tagging. To this end, we present a method for spelling normalization based on weighted edit distances, which exploits within-text spelling variation. We then evaluate the improvement in taging accuracy resulting from between-texts spelling normalization in two tagging experiments on several Early New High German (ENHG) texts.
Ein wichtiges Anliegen aller Privatrechtsordnungen ist die Sicherheit und Verlässlichkeit des Gütertransfers. In einer entwickelten Wirtschaft, die auf Arbeitsteilung und Umsatz basiert, gibt es lange Lieferketten. Person A liefert ein Gut an B, dann liefert B an C und immer so weiter. Die einzelnen Glieder in der Kette müssen das Gut sicher und verlässlich erwerben können. Wenn nun aber das Geschäft zwischen A und B von Anfang an ungültig ist oder nachträglich hinfällig wird, stellt sich die Frage, wem das Gut gehört. Das deutsche Recht begegnet dieser Frage unter anderem mit dem Trennungs- und Abstraktionsprinzip: Kauf und Übereignung sind zwei gesonderte Verträge, und die Wirksamkeit der Übereignung ist unabhängig vom Bestand und von der Wirksamkeit des Kaufvertrag. Das wird von deutschen Juristen als Schlüssel wissenschaftlichen Rechtsdenkens hochgehalten, stößt aber außerhalb Deutschlands und speziell in Frankreich auf Unverständnis. Denn im französischen Recht sind Kauf und Übereignung Eins.
Im Folgenden geht es nicht so sehr um die geistige Qualität des deutschen Trennungs- und Abstraktionsprinzips, die unbestreitbar ist, sondern vor allem um die Frage, ob diese Prinzi-pien im Vergleich zur französischen Einheit von Kauf und Übereignung praktische Vorteile haben. Die Untersuchung konzentriert sich auf die Übertragung von beweglichen Sachen und von Rechten. Das Grundstücksrecht bleibt dagegen ausgeklammert, denn es ist wegen seiner Formalien schwerer zu vergleichen und trägt keine grundlegend neuen Erkenntnisse bei.
Dieses Buch bietet eine Einführung in das Informationsmanagement in kommentierter Form. Es richtet sich in erster Linie an Studierende der Betriebswirtschaftslehre und der Wirtschaftsinformatik.
Der erste Teil des Buches gibt einen einführenden Überblick über die grundlegende Begriffe und Ansätze des Informationsmanagements. Es wird ein Modell des Informationsmanagements vorgestellt, auf dessen Basis die Aufgaben des Informationsmanagements in den folgenden Kapiteln vertieft werden. Der zweite Teil widmet sich der Informationswirtschaft und behandelt Informationsnachfrage und -angebot. Im dritten Teil des Buches werden die betrieblichen Informationssysteme mit ihren grundlegenden Bausteinen Daten und Prozesse thematisiert. Der vierte Teil gibt einen Überblick über Anwendungssysteme für die Produktion und die Aufgaben des Managements der Informations- und Kommunikationstechnik. Das abschließende Kapitel beinhaltet eine Diskussion relevanter Führungsaufgaben des
Standortmarketing
(2014)
Wann ist ein Standort für Unternehmen attraktiv? Niedrige Steuern, kluge Köpfe, gute Infrastruktur und sozialer Frieden sind wichtige Standortfaktoren. Das Lehrbuch geht auf den zunehmend international geführten Standortwettbewerb ein. Es analysiert die Parameter einer Standortentscheidung und stellt ein Marketing- und Managementkonzept für Regionen vor.
Dieses Buch bietet eine Einführung in das Produktionsmanagement in kommentierter Form. Der erste Teil des Buches gibt einen einführenden Überblick über grundlegende Begriffe der Produktionswirtschaft und systematisiert Produktionsfaktoren, Produktionssysteme und Produkte. Im zweiten Teil geht es um strategische Aspekte des Produktionsmanagements, wie Standortwahl und Produktstrategie, sowie um die Festlegung des Produktionsprogramms. Teil 3 behandelt mit der Gestaltung des Produktionssystems und menschlicher Arbeit die Potenzialfaktoren der Produktion. Gegenstand des vierten Teils ist die Versorgung der Produktion mit dem benötigten Material. Hier werden Fragen der Materialbedarfsermittlung, der Beschaffung und der Lagerhaltung beleuchtet. Im fünften Teil werden relevante Konzepte der operativen Produktionsplanung und -steuerung vorgestellt und die besonderen Planungsprobleme in der Einzel-, Auftrags- und Variantenfertigung betrachtet. Im Fokus des sechsten Teils steht die Serien- und Massenfertigung.
In the Posthomerica references to an omnipotent fate or to the power of the gods are strikingly frequent. Modern scholarship has often treated this as Stoic. Closer reading reveals that Quintus is, on the one hand, following the Homeric concept of double motivation, according to which humans can be motivated by a deity only to an act that conforms to their character and for which they are responsible. On the other hand, Quintus gives these statements on responsibility to characters who are trying to excuse their own acts to themselves and, particularly, to others, i.e. they are motivated contextually. It would be non-Stoic to excuse oneself for a bad deed by reference to an almighty fate. It seems that Quintus, by presenting this tension, wanted the reader to reconsider and reflect on the different concepts.
The use of silver nanoparticles in medical and consumer products such as wound dressings, clothing and cosmetic has increased significantly in recent years. Still, the influence of these particles on our health and especially on our brain, has not been examined adequately up to now. We studied the influence of AgEO- (Ethylene Oxide) and AgCitrate-Nanoparticles (NPs) on the protective barriers of the brain, namely the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (blood-CSF) barrier in vitro. The NPs toxicity was evaluated by examining changes in membrane integrity, cell morphology, barrier properties, oxidative stress and inflammatory reactions. AgNPs decreased cell viability, disturbed barrier integrity and tight junctions and triggered oxidative stress and DNA strand breaks. However, all mentioned effects were, at least partly, suppressed by a Citrate-coating and were most pronounced in the cells of the BBB as compared to the epithelial cells representing the blood-CSF barrier. AgEO- but not AgCitrate-NPs also triggered an inflammatory reaction in porcine brain capillary endothelial cells (PBCEC), which represent the BBB.
Our data indicate that AgNPs may cause adverse effects within the barriers of the brain, but their toxicity can be reduced by choosing an appropriate coating material.
Ultraschall Berlin
(2014)
Ausgehend von der typischen IT‐Infrastruktur für E‐Learning an Hochschulen auf der einen Seite sowie vom bisherigen Stand der Forschung zu Personal Learning Environments (PLEs) auf der anderen Seite zeigt dieser Beitrag auf, wie bestehende Werkzeuge bzw. Dienste zusammengeführt und für die Anforderungen der modernen, rechnergestützten Präsenzlehre aufbereitet werden können. Für diesen interdisziplinären Entwicklungsprozess bieten sowohl klassische Softwareentwicklungsverfahren als auch bestehende PLE‐Modelle wenig Hilfestellung an. Der Beitrag beschreibt die in einem campusweiten Projekt an der Universität Potsdam verfolgten Ansätze und die damit erzielten Ergebnisse. Dafür werden zunächst typische Lehr‐/Lern‐bzw. Kommunikations‐Szenarien identifiziert, aus denen Anforderungen an eine unterstützende Plattform abgeleitet werden. Dies führt zu einer umfassenden Sammlung zu berücksichtigender Dienste und deren Funktionen, die gemäß den Spezifika ihrer Nutzung in ein Gesamtsystem zu integrieren sind. Auf dieser Basis werden grundsätzliche Integrationsansätze und technische Details dieses Mash‐Ups in einer Gesamtschau aller relevanten Dienste betrachtet und in eine integrierende Systemarchitektur überführt. Deren konkrete Realisierung mit Hilfe der Portal‐Technologie Liferay wird dargestellt, wobei die eingangs definierten Szenarien aufgegriffen und exemplarisch vorgestellt werden. Ergänzende Anpassungen im Sinne einer personalisierbaren bzw. adaptiven Lern‐(und Arbeits‐)Umgebung werden ebenfalls unterstützt und kurz aufgezeigt.
Mobile Endgeräte und die dazugehörigen Applikationen sind zu einem unverzichtbaren Bestandteil des täglichen Lebens geworden und ermöglichen den ortsund zeitunabhängigen Zugriff auf wichtige Informationen. Hochschulspezifische An- gebote sind im mobilen Bereich hingegen noch immer nicht flächendeckend anzutreffen und lassen sich i. d. R. nur auf Einzelaktivitäten Studierender und Lehrender zurückführen. Dabei können mobile Applikationen einen essentiellen Beitrag zur Verbesserung der studentischen Selbstorganisation sowie für die Ausgestaltung und Ergänzung von konkreten Lehr-/Lernszenarien leisten. Dieser Artikel stellt ein modulares Hochschul-App-Framework vor, das sowohl zentrale campusbezogene Dienste als auch dezentrale Lernapplikationen unter einer Oberfläche vereint anbietet. Anhand einer Analyse von Stärken und Schwächen werden verschiedene Ansätze in Hinblick auf Anforderungen, Entwicklung, Wartung und Betrieb der Hochschul-App zusammengefasst und bewertet. Es wird auf die zugrundeliegende serviceorientierte Architektur eingegangen, die eine Portierung der Applikation auf andere Hochschulen mit einem vertretbaren Aufwand ermöglicht. Der Beitrag schließt mit einer Darstellung der ersten Ergebnisse und weiterführender Überlegungen und Arbeiten.
Institutions are facing the challenge to integrate legacy systems with steadily growing new ones, using different technologies and interaction patterns. With the demand of offering the best potential of all systems, several not matching systems including their functions have to be aggregated and offered in a useable way. This paper presents an adaptive, generalizable and self-organized Personal Learning Environment (PLE) framework with the potential to integrate several heterogeneous services using a service-oriented architecture. First, a general overview over the field is given, followed by the description of the core components of the PLE framework. A prototypical implementation is presented. Finally, it’s shown how the PLE framework can be dynamically adapted to a changing system environment, reflecting experiences from first user studies.
Spurensuche
(2014)
The background of civil service reform in Indonesia reveals the emergence of the reformation movement in 1998, following the fall of the authoritarian New Order regime. The reformation movement has seen the introduction of reforms in Indonesia's various governmental institutions, including the civil service. The civil service reforms were marked by the revision of Act 8/ 74 with Act 43 of 1999 on Civil Service Administration. The implementation of the civil service reform program, which was carried out by both central and local governments, required cooperation between the actors (in particular, Ministries, agencies and local governments), known as coordination.
Currently, the coordination that occurs between actors tends to be rigid and hierarchical. As a result, targets are not efficiently and effectively met. Hierarchical coordination, without a strong public sector infrastructure, tends to have a negative impact on achieving the desired outcomes of the civil service reform program. As an intrinsic part of the New Order regime, hierarchical coordination resulted in inefficiency and lack of efficacy. Despite these inefficiencies, the administration and the political environment have changed significantly as a result of the reform process.
Obvious examples of the reforms are changes in recruitment patterns, placement and remuneration policies. However, in the case of Indonesia, it appears that every state institution has its own policy. Thus, it appears that there has not been policy coherence in the civil service reform program, resulting in the lack of a sustainable program. The important thing to examine is how the coordination mechanisms of the civil service reform program in the central government have developed during the reform era in Indonesia
The purpose of this study is to analyse the linkages between coordination mechanisms and the actual implementation of civil service reform programs. This is undertaken as a basis for intervention based on the structures and patterns of coordination mechanisms in the implementation of civil service reform programs. The next step is to formulate the development coordination mechanisms, particularly to create structures and patterns of civil service reforms which are more sustainable to the specific characteristics of public sector organisations in Indonesia.
The benefits of this research are a stronger understanding of the linkages between the mechanisms of coordination and implementation of civil service reform programs. Through this analysis, the findings can then be applied as a basic consideration in planning a sustainable civil service reform program. In the basis of theoretical issues concerning the linkages between coordination mechanisms and implementation of civil service reform program sustainability, this book explores the type of coordination, which is needed to test the proportional and sustainable concept of the intended civil service reform program in Indonesia.
Research conducted through studies, surveys and donors has shown that poor coordination is the major hindrance to the civil service program reform in Indonesia. This research employs a qualitative approach. In this study, the coordination mechanisms and implementations of civil service reform programs are demonstrated by means of case studies of the State Ministry for Administrative Reform, the National Civil Service Agency and the National Public Administration Institute. The coordination mechanisms in these Ministries and agencies were analysed using indicators of effective and efficient coordination. The analysis of the coordination mechanisms shows a tendency towards rigid hierarchical coordination. This raises concerns about fragmentation among departments and agencies at the central government level and calls for integrated civil service reform both at central and local governmental levels. In the context of implementation programs, a hierarchical mechanism of coordination leverages on various aspects, such as the program formulation, implementation flow of the program, the impact of policies, and achievement targets. In particular, there was a shift process of the mainstream civil service reform in the Ministries and agencies which are marked by the emergence of sectoral interest and inefficiencies in the civil service reform program. The primary result of successful civil service reform is increased professionalism in the civil service.
The findings on hierarchical mechanisms and the prescriptions which will follow show that the professionalism of Indonesia’s civil service is at stake. The implementation of the program through coordination mechanisms in Ministries and agencies is measured in various dimensions: the centre of coordination, integration of coordination, sustainability of coordination and multidimensionality of coordination.
The results of this analysis show that coordination mechanisms and the implementation of civil service reform are more successful when they are integration rather than hierarchical mechanisms. For a successful implementation of the reform program, it is crucial to intervene and change the type of coordination at the central government through the integration approach (hierarchy, market, and network). Furthermore, in order to move towards the integration type mechanism of coordination the separation of the administration and politics in the practice of good governance needs to be carried out immediately and simultaneously. Based on this analysis, it can be concluded that the integration type mechanism of coordination is a suitable for Indonesia for a sustainable civil service reform program. Finally, to achieve coherent civil service reforms, national policies developed according to the central government's priorities are indispensable, establishing a coordination mechanism that can be adhered to throughout all reform sectors.
Memoiren der Macht
(2014)
Unfälle der Sprache
(2014)
Der Begriff »Katastrophe« hat in unserer Alltags- und Mediensprache Hochkonjunktur. Was in der Abfolge von Kriegen, Attentaten, Erdbeben, Vulkanausbrüchen und Tsunamis als »Katastrophe« bezeichnet wird, verlangt nach einer zugespitzten Analyse. In der Literaturwissenschaft wird der Ausdruck als Bezeichnung für das schreckliche Unglück verwendet, mit dem eine Tragödie endet. Die »Strophe« bezeichnet dabei ursprünglich die körperliche Drehung, mit welcher der Chor in der antiken Tragödie seinen Gesang begleitete, bevor etwas Neues beginnt ..
A Little Piece of the Shire
(2014)
Rezensiertes Werk
George, Rosemary Marangoly, Indian English and the Fiction of National Literature - Cambridge: Cambridge University Press, 2013. - Hb. viii, 285 pp. - (Zeitschrift für Anglistik und Amerikanistik ; 62(4))
ISBN 978-1-107-04000-7.
Uno sguardo che renda omogenee le teorie della lingua relative al XVII e al XVIII secolo non può cogliere che a grandi linee la realtà delle concezioni della lingua abbracciate in questo periodo. Il riconoscimento di una teoria cartesiana della lingua come la spiegazione indifferenziata degli sviluppi conseguenti il passaggio da visioni razionalistiche a concezioni orientate ai sensi sono risultato di tale omogeneizzazione, un processo che contempla la realtà solo in parte.
Il pensiero linguistico era contrassegnato da un misto di forme di riflessione di carattere narrativo e di tipo concettuale-razionale che si completavano in modo reciproco. Se l’approccio concettuale tentava di rilevare le proprietà fondamentali della lingua e ordinarle razionalmente, le forme narrative della riflessione linguistica non si rivolgevano alla lingua in quanto oggetto concettuale. Piuttosto la rappresentavano come oggetto da comprendere. Gli approcci narrativi e concettuali alla lingua prevedono differenze discorsive nelle impostazioni teorico-linguistiche. Anche lo stampo del pensiero teoretico-linguistico contribuisce, attraverso tradizioni differenti, alla molteplicità delle vedute teoretico-linguistiche. Per tradizioni intendiamo posizioni dominanti nella riflessione metalinguistica, presenti in contesti regionali, che possono differenziarsi da altre tradizioni. Ad ogni modo, anche il ritardato sviluppo o la ricezione di teorie linguistiche può condurre a differenze caratteristiche. Le teorie linguistiche dell´Illuminismo furono per esempio recepite in Spagna più tardi che in altri Paesi europei. Ciò condusse all’accettazione sincronica di elementi teorici relativi a teorie diverse e consecutive. Se si concentra l’attenzione al di fuori dell’Europa si verrà attratti dallo sviluppo degli approcci analoghi alla riflessione linguistica che trovarono sviluppo in Cina all’inizio del XX secolo.
Unità e diversità sono tuttavia rintracciabili non solo sul piano della conoscenza metalinguistica ma anche sul piano dell’oggetto. Una sfida per la descrizione della lingua orientata alla tradizione greco-latina era rappresentata dalle lingue indigene con le quali si stava iniziando ad entrare in contatto attraverso i viaggi di scoperta e in seguito all’inizio del colonialismo. Da affiancare alla comunicazione esogena della trasmissione metalinguistica dei rapporti nell’ambito delle lingue europee sono presenti anche approcci per una percezione della specificità categoriale delle lingue americane. Sebbene in alcuni casi non verranno riconosciute le giuste categorizzazioni per le lingue descritte, per lo meno verrà assodato che le categorie rese note dalla grammatica latina non sussistono.
Nella ricerca degli ultimi decenni, la rappresentazione di un paradigma della filosofia della lingua del XVII e del XVIII secolo che postordini e subordini universalmente la molteplicità delle lingue a strutture valide di pensiero e che prescriva per la riflessione linguistica categorie fisse di una grammatica generale strettamente orientata alla logica razionalistica è stata più volte relativizzata. In quanto connessa con la fondatezza dell’unità e con l’inalterabilità del genere umano a seconda di spazio e tempo, la tesi che le lingue nella loro natura molteplice possano esistere solo alle dipendenze di una struttura universale del pensiero si lasciava catalogare tra quelle posizioni paradigmatiche sussistenti nell’ambito della filosofia della lingua di allora. Attraverso la conoscenza dell’origine storica dell’evoluzione dell’uomo, di tutti i suoi stili di vita e forme di comunicazione, assume rilievo un’altra posizione paradigmatica che attribuisce alla lingua un influsso formativo sul pensiero.
Attraverso la differenziazione ideologico-filosofica e la specificità nazionale delle sue tesi relative alla lingua in generale e alle lingue storiche in particolare la visione secolarizzata dell’uomo e della società elaborata all’apice dell’Illuminismo si associava allo sviluppo corrispettivo e al cambiamento delle posizioni teorico-linguistiche. Con la proclamazione della lingua e del pensiero come risultati di un lungo sviluppo corrispettivo nella storia dell’umanità viene assegnato nuovo valore alle prese di posizione sulla natura e sull’origine della lingua.
Il ciclo dei trentasei Contorni danteschi del pittore e disegnatore berlinese Giovanni Bonaventura Genelli (1798-1868) rappresenta un interessante tentativo d’interpretare il testo della Commedia alla luce dei principi del classicismo tedesco, sull’esempio di Carstens e di Koch e, in parte di Flaxman da cui però Genelli si distingue per continua ricerca volta ad esprimere la plasticità delle forme. Caratteristica precipua delle sue illustrazioni è inoltre il ricorso continuo sia alla scultura antica che agli affreschi michelangioleschi della Sistina come repertorio iconografico. L’articolo approfondisce questi aspetti con particolare riferimento alle sedici tavole dedicate all’Inferno.
Die staatsangehörigkeitsrechtliche Optionspflicht des § 29 StAG für in Deutschland geborene Kinder ausländischer Eltern, die jus soli die deutsche Staatsangehörigkeit erworben haben, bildete eine der Kernfragen des letzten Bundestagswahlkampfes. Im zwischen CDU/CSU und SPD abgeschlossenen Koalitionsvertrag ist vorgesehen, dass für in Deutschland geborene und aufgewachsene deutsche Kinder ausländischer Eltern in Zukunft der Optionszwang entfallen soll und die Mehrstaatigkeit akzeptiert wird, während es im Übrigen beim geltenden Staatsangehörigkeitsrecht bleiben soll. Der Beitrag untersucht vor diesem Hintergrund und im Lichte der nunmehr insoweit vorliegenden Entwürfe die sich aus diesen politischen Vorgaben ergebenden staatsangehörigkeitsrechtlichen Regelungsoptionen und -probleme.
2013 jährte sich das Inkrafttreten der Europäischen Menschenrechtskonvention zum 60. Mal. Seit ihrem Bestehen hat die Konvention insbesondere durch den auf ihrer Grundlage gegründeten Gerichtshof den Schutz der Menschenrechte in Europa wesentlich gestärkt. Mit ihren mittlerweile 47 Vertragsparteien ist sie zu einem gesamteuropäischen Grundrechtsschutzsystem geworden, dessen Akzeptanz sich nicht zuletzt an den in den vergangenen Jahren rasant gestiegenen Fallzahlen zeigt. Dennoch steht die EMRK auch in der Zukunft vor besonderen Herausforderungen. Dieser Band stellt den Versuch einer Bilanz der vergangenen 60 Jahre dar und enthält die Beiträge der Vortragenden des Workshops „60 Jahre Europäische Menschenrechtskonvention – die Konvention als ‚living instrument‘“, der anlässlich des Jubiläums durch das MenschenRechtsZentrum der Universität Potsdam veranstaltet wurde. Schwerpunktmäßig beschäftigen sich die Beiträge mit der Rechtsfortbildung durch den EGMR, insbesondere mittels einer dynamischen Auslegung der Konvention, der konstitutionellen Dimension der EMRK, der Durchsetzung seiner Urteile sowie dem Reformbedarf aufgrund gestiegener Arbeitsbelastung.
The Traité élémentaire de chimie (1789) is considered to be the first modern chemistry text. After the author, Antoine Laurent de Lavoisier (1743 - 1794), had defined the element as a pure substance that cannot be broken down into simpler entities, he introduced the method of chemical terminology in which he represented the elements in a more practical way as symbols. The translator Juan Manuel Munárriz followed the author in his conviction that it is impossible to separate the nomenclature from science for three reasons: the scientific facts, the ideas representing them, and the words that express the ideas.
En esta contribución estudiaré las denominaciones de las formas verbales espanolas, focalizando la atención en las formas del así llamado pasado y la relación de su potencial conceptual a la función de las formas respectivas. Las denominaciones de las formas verbales en las gramáticas espanolas desde el siglo XVII hasta el siglo XX se determinan por la tradición gramatical latina, pero también por posiciones teoréticas de sus autores.
Masked priming research with late (non-native) bilinguals has reported facilitation effects following morphologically derived prime words (scanner - scan). However, unlike for native speakers, there are suggestions that purely orthographic prime-target overlap (scandal - scan) also produces priming in non-native visual word recognition. Our study directly compares orthographically related and derived prime-target pairs. While native readers showed morphological but not formal overlap priming, the two prime types yielded the same magnitudes of facilitation for non-natives. We argue that early word recognition processes in a non-native language are more influenced by surface-form properties than in one's native language.
Two experiments examined the effects of dispositional optimism and attributions on feelings of success in a performance setting. In Experiment 1, participants successfully solved three cognitive tasks and attributed the success either internally (i.e., to themselves) or externally (i.e., to a teammate). We found no effect of optimism, but a significant effect of the attribution: Internal attribution predicted an increase in feelings of success. In Experiment 2, we replicated the design and adopted an extreme groups approach in order to include the extremes of the optimism dimension. Only optimism affected feelings of success in this sample: Pessimistic participants showed higher increases in feelings of success than optimistic participants. We conclude that optimism, if disentangled from attribution, may have an effect on affect, with pessimism showing potential affective benefits. However, this association may be concealed if samples with a restricted range of the optimism dimension are studied.
Purpose of reviewIncretin-based therapy with glucagon-like peptide-1 receptor (GLP-1R) agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors is considered a promising therapeutic option for type 2 diabetes mellitus. Cumulative evidence, mainly from preclinical animal studies, reveals that incretin-based therapies also may elicit beneficial effects on kidney function. This review gives an overview of the physiology, pathophysiology, and pharmacology of the renal incretin system.Recent findingsActivation of GLP-1R in the kidney leads to diuretic and natriuretic effects, possibly through direct actions on renal tubular cells and sodium transporters. Moreover, there is evidence that incretin-based therapy reduces albuminuria, glomerulosclerosis, oxidative stress, and fibrosis in the kidney, partially through GLP-1R-independent pathways. Molecular mechanisms by which incretins exert their renal effects are understood incompletely, thus further studies are needed.SummaryThe GLP-1R and DPP-4 are expressed in the kidney in various species. The kidney plays an important role in the excretion of incretin metabolites and most GLP-1R agonists and DPP-4 inhibitors, thus special attention is required when applying incretin-based therapy in renal impairment. Preclinical observations suggest direct renoprotective effects of incretin-based therapies in the setting of hypertension and other disorders of sodium retention, as well as in diabetic and nondiabetic nephropathy. Clinical studies are needed in order to confirm translational relevance from preclinical findings for treatment options of renal diseases.
A Co(II)-imidazolate-4-amide-5-imidate based MOF, IFP-5, is synthesized by using an imidazolate anion-based novel ionic liquid as a linker precursor under solvothermal conditions. IFP-5 shows significant amounts of gas (N-2, CO2, CH4 and H-2) uptake capacities. IFP-5 exhibits an independent high spin Co(II) centre and antiferromagnetic coupling.
We investigate nonlinear problems which appear as Euler-Lagrange equations for a variational problem. They include in particular variational boundary value problems for nonlinear elliptic equations studied by F. Browder in the 1960s. We establish a solvability criterion of such problems and elaborate an efficient orthogonal projection method for constructing approximate solutions.
The complementary advantages of GPS and seismic measurements are well recognized in seismotectonic monitoring studies. Therefore, integrated processing of the two data streams has been proposed recently in an attempt to obtain accurate and reliable information of surface displacements associated with earthquakes. A hitherto still critical issue in the integrated processing is real-time detection and precise estimation of the transient baseline error in the seismic records. Here, we report on a new approach by introducing the seismic acceleration corrected by baseline errors into the state equation system. The correction is performed and regularly updated in short epochs (with increments which may be as short as seconds), so that station position, velocity, and acceleration can be constrained very tightly and baseline error can be estimated as a random-walk process. With the adapted state equation system, our study highlights the use of a new approach developed for integrated processing of GPS and seismic data by means of sequential least-squares adjustment. The efficiency of our approach is demonstrated and validated using simulated, experimental, and real datasets. The latter were collected at collocated GPS and seismic stations around the 4 April 2010, E1 Mayor-Cucapah earthquake (Mw, 7.2). The results have shown that baseline errors of the strong-motion sensors are corrected precisely and high-precision seismic displacements are real-timely obtained by the new approach.
ResultsUnder conditions of elevated prenatal maternal stress, children carrying one or two DRD4 7r alleles were at increased risk of a diagnosis of CD/ODD. Moreover, homozygous carriers of the DRD4 7r allele displayed more externalizing behavior following exposure to higher levels of prenatal maternal stress, while homozygous carriers of the DRD4 4r allele turned out to be insensitive to the effects of prenatal stress.
ConclusionsThis study is the first to report a gene-environment interaction related to DRD4 and prenatal maternal stress using data from a prospective study, which extends earlier findings on the impact of prenatal maternal stress with respect to childhood antisocial behavior.
QuestionDoes eutrophication drive vegetation change in pine forests on nutrient deficient sites and thus lead to the homogenization of understorey species composition?
LocationForest area (1600ha) in the Lower Spreewald, Brandenburg, Germany.
MethodsResurvey of 77 semi-permanent plots after 45yr, including vascular plants, bryophytes and ground lichens. We applied multidimensional ordination of species composition, dissimilarity indices, mean Ellenberg indicator values and the concept of winner/loser species to identify vegetation change between years. Differential responses along a gradient of nutrient availability were analysed on the basis of initial vegetation type, reflecting topsoil N availability of plots.
ResultsSpecies composition changed strongly and overall shifted towards higher N and slightly lower light availability. Differences in vegetation change were related to initial vegetation type, with strongest compositional changes in the oligotrophic forest type, but strongest increase of nitrophilous species in the mesotrophic forest type. Despite an overall increase in species number, species composition was homogenized between study years due to the loss of species (mainly ground lichens) on the most oligotrophic sites.
ConclusionsThe response to N enrichment is confounded by canopy closure on the N-richest sites and probably by water limitation on N-poorest sites. The relative importance of atmospheric N deposition in the eutrophication effect is difficult to disentangle from natural humus accumulation after historical litter raking. However, the profound differences in species composition between study years across all forest types suggest that atmospheric N deposition contributes to the eutrophication, which drives understorey vegetation change and biotic homogenization in Central European Scots pine forests on nutrient deficient sites.
Not only the apples
(2014)
Focus sensitive particles highlight the relevance of contextual alternatives for the interpretation of a sentence. Two experiments tested whether this leads to better encoding and therefore, ultimately, better recall of focus alternatives. Participants were presented with auditory stimuli that introduced a set of elements ("context sentence") and continued in three different versions: the critical sentences either contained the exclusive particle nur ("only"), the inclusive particle sogar ("even"), or no particle (control condition). After being exposed to blocks of ten trials, participants were asked to recall the elements in the context sentence. The results show that both particles enhanced memory performance for the alternatives to the focused element, relative to the control condition. The results support the assumption that information-structural alternatives are better encoded in memory in the presence of a focus sensitive particle.
To assess the ecological and economic implications of the redistributive land reform in semi-arid Namibia, we investigated to what extent land reform beneficiaries adjust herd size and herd composition according to environmental (rainfall, vegetation) and economic variables (herd size, financial assets, running costs). We performed model-based role-plays with Namibian land reform beneficiaries, simulating 10 years of rangeland management.
Our study revealed that the farmers surveyed mainly manage their herds according to their economic situation (herd size and account balance) but do not take environmental variability (rainfall and vegetation) into account. Further, our results indicate that, due to financial pressure, farmers are not able to apply their desired management strategies, and that owners of small farms face a higher risk of economic failure. However, farmers apply rather conservative and constant stocking rates and will thus, given the current economic limitations, likely not contribute to semi-arid savanna degradation.
We conclude that land reform beneficiaries need support to be able to apply straightforward and efficient management strategies. This could be achieved by facilitating cooperation between small farming businesses and by supporting initial investment in productive cattle herds at the time of redistribution of the land.
In addition to sensory decline, age-related losses in auditory perception also reflect impairments in attentional modulation of perceptual saliency. Using an attention and intensity-modulated dichotic listening paradigm, we investigated electrophysiological correlates of processing conflicts between attentional focus and perceptual saliency in 25 younger and 26 older adults. Participants were instructed to attend to the right or left ear, and perceptual saliency was manipulated by varying the intensities of both ears. Attentional control demand was higher in conditions when attentional focus and perceptual saliency favored opposing ears than in conditions without such conflicts. Relative to younger adults, older adults modulated their attention less flexibly and were more influenced by perceptual saliency. Our results show, for the first time, that in younger adults a late negativity in the event-related potential (ERP) at fronto-central and parietal electrodes was sensitive to perceptual-attentional conflicts during auditory processing (N450 modulation effect). Crucially, the magnitude of the N450 modulation effect correlated positively with task performance. In line with lower attentional flexibility, the ERP waveforms of older adults showed absence of the late negativity and the modulation effect. This suggests that aging compromises the activation of the frontoparietal attentional network when processing the competing and conflicting auditory information.
The basin-scale spatial variability in lipid biomarker proxies in lacustrine sediments, which are established tools for studying continental environmental change, has rarely been examined. It is often implicitly assumed that a lake sediment core provides an average integral of catchment sources. Here we evaluated the distribution of lipid biomarkers in a modern ecosystem and compared it with the sedimentary record. We analyzed lipid biomarkers in terrestrial and aquatic organisms and in lake surface sediments from 17 locations within the saline-alkaline Lonar crater lake in central India. Terrestrial vegetation and lake surface sediments were characterized by relatively high average chain length (ACL) index values (29.6-32.8) of leaf wax n-alkanes, consistent with suggestions that plants in drier and warmer climates produce longer chain alkyl lipids than plants in cooler and humid areas. A heterogeneous spatial distribution of ACL values in lake surface sediments was found: at locations away from the shore, the values were highest (31 or more), possibly indicating different sources and/or transport of terrestrial biomarkers. In floating, benthic microbial mats and surface sediment, n-heptadecane, carotenoids, diploptene, phytol and tetrahymanol occurred in large amounts. Interestingly, these biomarkers of a unique bacterial community were found in substantially higher concentrations in nearshore sediment samples. We suggest that human influence and subsequent nutrient supply resulted in increased primary productivity, leading to an unusually high concentration of tetrahymanol in the nearshore sediments. In summary, the data showed that substantial heterogeneity existed within the lake, but leaf wax n-alkanes in a core from the center of the lake represented an integral of catchment conditions. However, lake level fluctuation may potentially affect aquatic lipid biomarker distributions in lacustrine sediments, in addition to source changes.
carriers on illumination. Efficient organic solar cells require a high yield for this process, combined with a minimum of energy losses. Here, we investigate the role of the lowest energy emissive interfacial charge-transfer state (CT1) in the charge generation process. We measure the quantum yield and the electric field dependence of charge generation on excitation of the charge-transfer (CT) state manifold viaweakly allowed, low-energy optical transitions. For a wide range of photovoltaic devices based on polymer: fullerene, small-molecule:C-60 and polymer: polymer blends, our study reveals that the internal quantum efficiency (IQE) is essentially independent of whether or not D, A or CT states with an energy higher than that of CT1 are excited. The best materials systems show an IQE higher than 90% without the need for excess electronic or vibrational energy.
Word features in parafoveal vision influence eye movements during reading. The question of whether readers extract semantic information from parafoveal words was studied in 3 experiments by using a gaze-contingent display change technique. Subjects read German sentences containing 1 of several preview words that were replaced by a target word during the saccade to the preview (boundary paradigm). In the 1st experiment the preview word was semantically related or unrelated to the target. Fixation durations on the target were shorter for semantically related than unrelated previews, consistent with a semantic preview benefit. In the 2nd experiment, half the sentences were presented following the rules of German spelling (i.e., previews and targets were printed with an initial capital letter), and the other half were presented completely in lowercase. A semantic preview benefit was obtained under both conditions. In the 3rd experiment, we introduced 2 further preview conditions, an identical word and a pronounceable nonword, while also manipulating the text contrast. Whereas the contrast had negligible effects, fixation durations on the target were reliably different for all 4 types of preview. Semantic preview benefits were greater for pretarget fixations closer to the boundary (large preview space) and, although not as consistently, for long pretarget fixation durations (long preview time). The results constrain theoretical proposals about eye movement control in reading.
This article addresses the transformation of a process model with an arbitrary topology into an equivalent structured process model. In particular, this article studies the subclass of process models that have no equivalent well-structured representation but which, nevertheless, can be partially structured into their maximally-structured representation. The transformations are performed under a behavioral equivalence notion that preserves the observed concurrency of tasks in equivalent process models. The article gives a full characterization of the subclass of acyclic process models that have no equivalent well-structured representation, but do have an equivalent maximally-structured one, as well as proposes a complete structuring method. Together with our previous results, this article completes the solution of the process model structuring problem for the class of acyclic process models.
In grape (Vitis vinifera), abscisic acid (ABA) accumulates during fruit ripening and is thought to play a pivotal role in this process, but the molecular basis of this control is poorly understood. This work characterizes ABSCISIC ACID RESPONSE ELEMENT-BINDING FACTOR2 (VvABF2), a grape basic leucine zipper transcription factor belonging to a phylogenetic subgroup previously shown to be involved in ABA and abiotic stress signaling in other plant species. VvABF2 transcripts mainly accumulated in the berry, from the onset of ripening to the harvesting stage, and were up-regulated by ABA. Microarray analysis of transgenic grape cells overexpressing VvABF2 showed that this transcription factor up-regulates and/or modifies existing networks related to ABA responses. In addition, grape cells overexpressing VvABF2 exhibited enhanced responses to ABA treatment compared with control cells. Among the VvABF2-mediated responses highlighted in this study, the synthesis of phenolic compounds and cell wall softening were the most strongly affected. VvABF2 overexpression strongly increased the accumulation of stilbenes that play a role in plant defense and human health (resveratrol and piceid). In addition, the firmness of fruits from tomato (Solanum lycopersicum) plants overexpressing VvABF2 was strongly reduced. These data indicate that VvABF2 is an important transcriptional regulator of ABA-dependent grape berry ripening.
Motivated by recent experimental observations of a rapid spontaneous DNA coil-globule transition on freestanding cationic lipid bilayers, we propose simple theoretical models for DNA condensation on cationic lipid membranes. First, for a single DNA rod, we examine the conditions of full wrapping of a cylindrical DNA-like semi-flexible polyelectrolyte by an oppositely charged membrane. Then, for two parallel DNA rods, we self-consistently analyze the shape and the extent of the membrane enveloping them, focusing on membrane elastic deformations and the membrane-DNA embracing angle, which enables us to compute the membrane-mediated DNA-DNA interactions. We examine the effects of the membrane composition and its charge density, which are the experimentally tunable parameters. We show that membrane-driven rod-rod attraction is more pronounced for higher charge densities and for smaller surface tensions of the membrane. Thus, we demonstrate that for a long DNA chain adhered to a cationic lipid membrane, such membrane-induced DNA-DNA attraction can trigger compaction of DNA.
The southern foreland basin of the Alborz Mountains of northern Iran is characterized by an approximately 7.3-km-thick sequence of Miocene sedimentary rocks, constituting three basin-wde coarsening-upward units spanning a period of 10(6)years. We assess available magnetostratigraphy, paleoclimatic reconstructions, stratal architecture, records of depositional environments, and sediment-provenance data to characterize the relationships between tectonically-generated accommodation space (A) and sediment supply (S). Our analysis allows an inversion of the stratigraphy for particular forcing mechanisms, documenting causal relationships, and providing a basis to decipher the relative contributions of tectonics and climate (inferred changes in precipitation) in controlling sediment supply to the foreland basin. Specifically, A/S>1, typical of each basal unit (17.5-16.0, 13.8-13.1 and 10.3-9.6Ma), is associated with sharp facies retrogradation and reflects substantial tectonic subsidence. Within these time intervals, arid climatic conditions, changes in sediment provenance, and accelerated exhumation in the orogen suggest that sediment supply was most likely driven by high uplift rates. Conversely, A/S<1 (13.8 and 13.8-11Ma, units 1, and 2) reflects facies progradation during a sharp decline in tectonic subsidence caused by localized intra-basinal uplift. During these time intervals, climate continued to be arid and exhumation active, suggesting that sediment supply was again controlled by tectonics. A/S<1, at 11-10.3Ma and 9-6-7.6Ma (and possibly 6.2; top of units 2 and 3), is also associated with two episodes of extensive progradation, but during wetter phases. The first episode appears to have been linked to a pulse in sediment supply driven by an increase in precipitation. The second episode reflects a balance between a climatically-induced increase in sediment supply and a reduction of subsidence through the incorporation of the proximal foreland into the orogenic wedge. This in turn caused an expansion of the catchment and a consequent further increase in sediment supply.
The present study proposes a General Probabilistic Framework (GPF) for uncertainty and global sensitivity analysis of deterministic models in which, in addition to scalar inputs, non-scalar and correlated inputs can be considered as well. The analysis is conducted with the variance-based approach of Sobol/Saltelli where first and total sensitivity indices are estimated. The results of the framework can be used in a loop for model improvement, parameter estimation or model simplification. The framework is applied to SWAP, a 113 hydrological model for the transport of water, solutes and heat in unsaturated and saturated soils. The sources of uncertainty are grouped in five main classes: model structure (soil discretization), input (weather data), time-varying (crop) parameters, scalar parameters (soil properties) and observations (measured soil moisture). For each source of uncertainty, different realizations are created based on direct monitoring activities. Uncertainty of evapotranspiration, soil moisture in the root zone and bottom fluxes below the root zone are considered in the analysis. The results show that the sources of uncertainty are different for each output considered and it is necessary to consider multiple output variables for a proper assessment of the model. Improvements on the performance of the model can be achieved reducing the uncertainty in the observations, in the soil parameters and in the weather data. Overall, the study shows the capability of the GPF to quantify the relative contribution of the different sources of uncertainty and to identify the priorities required to improve the performance of the model. The proposed framework can be extended to a wide variety of modelling applications, also when direct measurements of model output are not available.
We investigated whether 12-month-old infants rely on information about the certainty of goal selection in order to predict observed reaching actions. Infants' goal-directed gaze shifts were recorded as they observed action sequences in a multiple-goals design. We found that 12-month-old infants exhibited gaze shifts significantly earlier when the observed hand reached for the same goal object in all trials (frequent condition) compared with when the observed hand reached for different goal objects across trials (nonfrequent condition). Infants in the frequent condition were significantly more accurate at predicting the action goal than infants in the nonfrequent condition. In addition, findings revealed rapid learning in the case of certainty and no learning in the case of uncertainty of goal selection over the course of trials. Together, our data indicate that by the end of their first year of life, infants rely on information about the certainty of goal selection to make inferences about others' action goals.
There is much interest in the identification of the main drivers controlling changes in the microbial community that may be related to sustainable land use. We examined the influence of soil properties and land-use intensity (N fertilization, mowing, grazing) on total phospholipid fatty acid (PLFA) biomass, microbial community composition (PLFA profiles) and activities of enzymes involved in the C, N, and P cycle. These relationships were examined in the topsoil of grasslands from three German regions (Schorfheide-Chorin (SCH), Hainich-Dun (HAI), Schwabische Alb (ALB)) with different parent material. Differences in soil properties explained 60% of variation in PLFA data and 81% of variation in enzyme activities across regions and land-use intensities. Degraded peat soils in the lowland areas of the SCH with high organic carbon (OC) concentrations and sand content contained lower PLFA biomass, lower concentrations of bacterial, fungal, and arbuscular mycorrhizal PLFAs, but greater enzyme activities, and specific enzyme activities (per unit microbial biomass) than mineral soils in the upland areas of the HAI and ALB, which are finer textured, drier, and have smaller OC concentrations. After extraction of variation that originated from large-scale differences among regions and differences in land-use intensities between plots, soil properties still explained a significant amount of variation in PLFA data (34%) and enzyme activities (60%). Total PLFA biomass and all enzyme activities were mainly related to OC concentration, while relative abundance of fungi and fungal to bacterial ratio were mainly related to soil moisture. Land-use intensity (LUI) significantly decreased the soil C:N ratio. There was no direct effect of LUI on total PLFA biomass, microbial community composition, N and P cycling enzyme activities independent of study region and soil properties. In contrast, the activities and specific activities of enzymes involved in the C cycle increased significantly with LUI independent of study region and soil properties, which can have impact on soil organic matter decomposition and nutrient cycling. Our findings demonstrate that microbial biomass and community composition as well as enzyme activities are more controlled by soil properties than by grassland management at the regional scale.
In this opinion article we propose a scenario detailing how two crucial components have evolved simultaneously to ensure the transition of glycogen to starch in the cytosol of the Archaeplastida last common ancestor: (i) the recruitment of an enzyme from intracellular Chlamydiae pathogens to facilitate crystallization of alpha-glucan chains; and (ii) the evolution of novel types of polysaccharide (de)phosphorylating enzymes from preexisting glycogen (de)phosphorylation host pathways to allow the turnover of such crystals. We speculate that the transition to starch benefitted Archaeplastida in three ways: more carbon could be packed into osmotically inert material; the host could resume control of carbon assimilation from the chlamydial pathogen that triggered plastid endosymbiosis; and cyanobacterial photosynthate export could be integrated in the emerging Archaeplastida.
This study examined the relationship between ethnic identity, orientation toward the White mainstream culture, and psychological well-being among American Indians. In the light of the unique history of American Indians, we investigated the relationship between identification with the American Indian ingroup, orientation toward the dominant White American culture ( in terms of showing behavior typical for White mainstream culture as well as positive attitudes and feelings of belonging to White American culture), and self-efficacy and learned helplessness as indicators of psychological well-being. Structural equation analyses with an adolescent and an adult sample revealed a positive relationship between ethnic identity and self-efficacy but no link with learned helplessness. The tendency to show behavior typical for White mainstream culture was associated with higher self-efficacy in both samples and with lower helplessness in the adult subsample. White American orientation in the form of positive attitudes and sense of belonging were associated with higher helplessness in both samples and with lower self-efficacy among adults. The findings are discussed in terms of the role of both ethnic identity and the orientation toward the mainstream culture for well-being among American Indians, focusing on the distinct relations of White American behavior versus White American affiliation with well-being in American Indians.
On the role of fluoro-substituted nucleosides in DNA radiosensitization for tumor radiation therapy
(2014)
With the present theoretical study of the photochemical switching of E-methylfurylfulgide we contribute an important step towards the understanding of the photochemical processes in furylfulgide-related molecules. We have carried out large-scale, full-dimensional direct semiempirical configuration-interaction surface-hopping dynamics of the photoinduced ring-closure reaction. Simulated static and dynamical UV/Vis-spectra show good agreement with experimental data of the same molecule. By a careful investigation of our dynamical data, we were able to identify marked differences to the dynamics of the previously studied E-isopropylfurylfulgide. With our simulations we can not only reproduce the experimentally observed quantum yield differences qualitatively but we can also pinpoint two reasons for them: kinematics and pre-orientation. With our analysis, we thus offer straightforward molecular explanations for the high sensitivity of the photodynamics towards seemingly minor changes in molecular constitution. Beyond the realm of furylfulgides, these insights provide additional guidance to the rational design of photochemically switchable molecules.
In aquatic systems, natural organic matter (NOM) and in particular humic substances effectively absorb the ultraviolet (UV)/visible light spectrum of solar radiation and act as a photoprotective filter for organisms. Simultaneously, UV contributes to the generation of potentially harmful reactive oxygen species (ROS). Dose-response experiments were conducted on cyanobacteria and green algae with hydrogen peroxide (H2O2) as a long-lived representative of ROS. Delayed fluorescence (DF) decay kinetics was used as a non-invasive tool to follow changes of phytoplankton activity in real time. In order to investigate phototoxicity and photoprotection by NOM on phytoplankton, we exposed algae to UV-pre-irradiated NOM and direct UV excitation. Cyanobacteria responded to H2O2 concentrations as low as 10(-7) M, while green algae were 2 orders of magnitude less sensitive. UV irradiation of medium with NOM generated H2O2 concentrations of 1.5 x 10(-7) to 3.6 x 10(-7) M. When exposed to these concentrations, only the DF of cyanobacteria led to a measurable effect while that of green algae did not change. The addition of NOM protected all phytoplankton from direct UV irradiation, but cyanobacteria benefitted less. From this we conclude that UV-irradiated water enriched with NOM can adversely affect the physiology of cyanobacteria, but not of green algae, which might control phytoplankton composition and species-specific activities.
A method of real-time coseismic wave retrieving was proposed based on the tight integration of GPS, Glonass and strong-motion sensor observations, the validation and precision analysis have been made by an experimental data. The series of results have been shown that: by the integrated Kalman filter and multi-sensors, the coseismic waves can be optimally recovered by complement the advantages of each other, especially when the observation conditions are very bad. In additional, the results are not significantly effected by different receiver clock error processes for the integration solution.
Green algae are of great economic importance. Seaweed is consumed fresh or as seasoning in Japan. The commercial value is determined by quality, color, and flavor and is also strongly influenced by the production area. Our research, based on solid phase microextraction gas chromatography mass spectrometry (SPME-GC-MS), has revealed that volatile compounds differ intensely in the four varieties of commercial green algae. Accordingly, 41 major volatile compounds were identified. Heptadecene was the most abundant compound from Okayama (Ulva prolifera), Tokushima (Ulva prolifera), and Ehime prefecture (Ulva linza). Apocarotenoids, such as ionones, and their derivatives were prominent volatiles in algae from Okayama (Ulva prolifera) and Tokushima prefecture (Ulva prolifera). Volatile, short chained apocarotenoids are among the most potent flavor components and contribute to the flavor of fresh, processed algae, and algae-based products. Benzaldehyde was predominant in seaweed from Shizuoka prefecture (Monostroma nitidum). Multivariant statistical analysis (PCA) enabled simple discrimination of the samples based on their volatile profiles. This work shows the potential of SPME-GC-MS coupled with multivariant analysis to discriminate between samples of different geographical and botanical origins and form the basis for development of authentication methods of green algae products, including seasonings.
An atomistic molecular dynamics simulation approach is applied to model the influence of urethane linker units as well as the addition of water molecules on the simulated shape-memory properties of poly[(rac-lactide)-co-glycolide] (PLGA) and PLGA-based copolyester urethanes comprising different urethane linkers. The shape-memory performance of these amorphous packing models is explored in a simulated heating-deformation-cooling-heating procedure. Depending on the type of incorporated urethane linker, the mechanical properties of the dry copolyester urethanes are found to be significantly improved compared with PLGA, which can be attributed to the number of intermolecular hydrogen bonds between the urethane units. Good shape-memory properties are observed for all the modeled systems. In the dry state, the shape fixation is found to be improved by implementation of urethane units. After swelling of the copolymer models with water, which results in a reduction of their glass transition temperatures, the relaxation kinetics during unloading and shape recovery are found to be substantially accelerated.
Prokaryotic solute binding protein-dependent ATP-binding cassette import systems are divided into type land type II and mechanistic differences in the transport process going along with this classification are under intensive investigation. Little is known about the conformational dynamics during the catalytic cycle especially concerning the transmembrane domains. The type I transporter for positively charged amino acids from Salmonella enterica serovar Typhimurium (1A0-Hi5QMP2) was studied by limited proteolysis in detergent solution in the absence and presence of co-factors including ATP, ADP, LAO/arginine, and Mg2+ ions. Stable peptide fragments could be obtained and differentially susceptible cleavage sites were determined by mass spectrometry as Lys-258 in the nucleotide-binding subunit, HisP, and Arg-217/Arg-218 in the transmembrane subunit, HisQ In contrast, transmembrane subunit HisM was gradually degraded but no stable fragment could be detected. HisP and HisQ were equally resistant under pre- and post-hydrolysis conditions in the presence of arginine-loaded solute-binding protein LAO and ATP/ADP. Some protection was also observed with LAO/arginine alone, thus reflecting binding to the transporter in the apo-state and transmembrane signaling. Comparable digestion patterns were obtained with the transporter reconstituted into proteoliposomes and nanodiscs. Fluorescence lifetime spectroscopy confirmed the change of HisQ(R218) to a more apolar microenvironment upon ATP binding and hydrolysis. Limited proteolysis was subsequently used as a tool to study the consequences of mutations on the transport cycle. Together, our data suggest similar conformational changes during the transport cycle as described for the maltose ABC transporter of Escherichia coli, despite distinct structural differences between both systems.
Context. AMCVn systems are ultracompact binaries in which a (semi-) degenerate star transfers helium-dominated matter onto a white dwarf. They are effective gravitational-wave emitters and potential progenitors of Type Ia supernovae.
Aims. To understand the evolution of AMCVn systems it is necessary to determine their mass-loss rate through their radiation-driven accretion-disk wind. We constructed models to perform quantitative spectroscopy of P Cygni line profiles that were detected in UV spectra.
Methods. We performed 2.5D Monte Carlo radiative transfer calculations in hydrodynamic wind structures by making use of realistic NLTE spectra from the accretion disk and by accounting for the white dwarf as an additional photon source.
Results. We present first results from calculations in which LTE opacities are used in the wind model. A comparison with UV spectroscopy of the AMCVn prototype shows that the modeling procedure is potentially a good tool for determining mass-loss rates and abundances of trace metals in the helium-rich wind.
This article summarizes the latest results on the proton-to-electron mass ratio derived from H-2 observations at high redshift in the light of possible variations of fundamental physical constants. The focus lies on UVES observations of the past years as enormous progress was achieved since the first positive results on / were published. With the better understanding of systematics, dedicated observation runs, and numerous approaches to improve wavelength calibration accuracy, all current findings are in reasonable good agreement with no variation and provide an upper limit of / < 1 x 10(-5) for the redshift range of 2 < z < 3. ((
Miniaturized analytical chip devices like biosensors nowadays provide assistance in highly diverse fields of application such as point-of-care diagnostics and industrial bioprocess engineering. However, upon contact with fluids, the sensor requires a protective shell for its electrical components that simultaneously offers controlled access for the target analytes to the measuring units. We therefore developed a capsule that comprises a permeable and a sealed compartment consisting of variable polymers such as biocompatible and biodegradable polylactic acid (PLA) for medical applications or more economical polyvinyl chloride (PVC) and polystyrene (PS) polymers for bioengineering applications. Production of the sealed capsule compartments was performed by heat pressing of polymer pellets placed in individually designable molds. Controlled permeability of the opposite compartments was achieved by inclusion of NaCl inside the polymer matrix during heat pressing, followed by its subsequent release in aqueous solution. Correlating diffusion rates through the so made permeable capsule compartments were quantified for preselected model analytes: glucose, peroxidase, and polystyrene beads of three different diameters (1.4 mu m, 4.2 mu m, and 20.0 mu m). In summary, the presented capsule system turned out to provide sufficient shelter for small-sized electronic devices and gives insight into its potential permeability for defined substances of analytical interest.