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Foreword
(2019)
Effects of Drop Height on Jump Performance in Male and Female Elite Adolescent Handball Players
(2019)
Purpose: To examine the effects of drop height on drop-jump (DJ) performance and on associations between DJ and horizontal-jump/sprint performances in adolescent athletes. Methods: Male (n = 119, 2.5 [0.6] y post-peak-height velocity) and female (n = 120, 2.5 [0.5] y post-peak-height velocity) adolescent handball players (national level) performed DJs in randomized order using 3 drop heights (20, 35, and 50 cm). DJ performance (jump height, reactive strength index [RSI]) was analyzed using the Optojump Next system. In addition, correlations were computed between DJ height and RSI with standing-long-jump and 20-m linear-sprint performances. Results: Statistical analyses revealed medium-size main effects of drop height for DJ height and RSI (P <.001, 0.63 <= d <= 0.71). Post hoc tests indicated larger DJ heights from 20 to 35 and 35 to 50 cm (P <=.031, 0.33 <= d <= 0.71) and better RSI from 20- to 35-cm drop height (P <.001, d = 0.77). No significant difference was found for RSI between 35- and 50-cm drop height. Irrespective of drop height, associations of DJ height and RSI were small with 5-m-split time (-.27 <= r <=.05), medium with 10-m-split time (-.44 <= r <=.14), and medium to large with 20-m sprint time and standing-long-jump distance (-.57 <= r <=.22). Conclusions: The present findings indicate that, irrespective of sex, 35-cm drop heights are best suited to induce rapid and powerful DJ performance (ie, RSI) during reactive strength training in elite adolescent handball players. Moreover, training-related gains in DJ performance may at least partly translate to gains in horizontal jump and longer sprint distances (ie, >= 20-m) and/or vice versa in male and female elite adolescent athletes, irrespective of drop height.
IntroductionTo date, most studies of natural variation and metabolite quantitative trait loci (mQTL) in tomato have focused on fruit metabolism, leaving aside the identification of genomic regions involved in the regulation of leaf metabolism.ObjectiveThis study was conducted to identify leaf mQTL in tomato and to assess the association of leaf metabolites and physiological traits with the metabolite levels from other tissues.MethodsThe analysis of components of leaf metabolism was performed by phenotypying 76 tomato ILs with chromosome segments of the wild species Solanum pennellii in the genetic background of a cultivated tomato (S. lycopersicum) variety M82. The plants were cultivated in two different environments in independent years and samples were harvested from mature leaves of non-flowering plants at the middle of the light period. The non-targeted metabolite profiling was obtained by gas chromatography time-of-flight mass spectrometry (GC-TOF-MS). With the data set obtained in this study and already published metabolomics data from seed and fruit, we performed QTL mapping, heritability and correlation analyses.ResultsChanges in metabolite contents were evident in the ILs that are potentially important with respect to stress responses and plant physiology. By analyzing the obtained data, we identified 42 positive and 76 negative mQTL involved in carbon and nitrogen metabolism.ConclusionsOverall, these findings allowed the identification of S. lycopersicum genome regions involved in the regulation of leaf primary carbon and nitrogen metabolism, as well as the association of leaf metabolites with metabolites from seeds and fruits.
Plasticity in metabolism underpins local responses to nitrogen in Arabidopsis thaliana populations
(2019)
Nitrogen (N) is central for plant growth, and metabolic plasticity can provide a strategy to respond to changing N availability. We showed that two local A. thaliana populations exhibited differential plasticity in the compounds of photorespiratory and starch degradation pathways in response to three N conditions. Association of metabolite levels with growth-related and fitness traits indicated that controlled plasticity in these pathways could contribute to local adaptation and play a role in plant evolution.
Domestication syndrome has resulted in the large loss of genetic variation of crop plants. Because of such genetic loss, productivity of various beneficial secondary (specialized) metabolites that protect against abiotic/biotic stresses, has been narrowed in many domesticated crops. Many key regulators or structural genes of secondary metabolic pathways in the domesticated as well as wild tomatoes are still largely unknown. In recent studies, metabolic quantitative trait loci (mQTL) analysis using the population of introgression lines (ILs), each containing a single introgression from Solanum pennellii (wild tomato) in the genetic background of domesticated tomato (M82, Solanum lycopersicum), has been used for investigation of metabolic regulation and key genes involved in both primary and secondary metabolism. In this thesis, three research projects, i) understanding of metabolic linkage between branched chain amino acids (BCAAs) and secondary metabolism using antisense lines of BCAAs metabolic genes, ii) investigation of novel key genes involved in tomato secondary metabolism and fruit ripening, iii) mapping of drought stress responsive mQTLs in tomato, are presented and discussed. In the first part, metabolic linkage between leucine and secondary metabolism is investigated by analyzing antisense lines of four key genes (ketol-acid reductoisomerase, KARI; dihydroxy-acid dehydratase, DHAD; isopropylmalate dehydratase, IPMD and branched chain aminotransferases1, BCAT1) found previously in mQTL of leucine contents. Obtained results indicate that KARI might be a rate limiting enzyme for iC5 acyl-sucrose synthesis in young leaf but not in red ripe fruits. By integrating obtained results with previous reports, inductive metabolic linkage between BCAAs and other secondary metabolic pathways at DHAD transcriptional levels in fruit is proposed. In the second part, candidate genes that are involved in secondary metabolism and fruit ripening in tomato were found by the approach of expression quantitative trait loci (eQTL) analysis. To predict functions of those candidate genes, functional validation by virus induced gene silencing and transient overexpression were performed. Results obtained by analyzing T0 overexpression and artificial miRNA lines for some of those candidates confirm their predicted functions, for example involved in fruit ripening (WD40, Solyc04g005020) and iC5 acyl-sucrose synthesis (P450, Solyc03g111940). In the third part, mapping of drought stress responsive mQTLs was performed using 57 S. pennellii ILs population. Evaluation of genetic architecture of mQTL analysis resulted in identifying drought responsive ILs (11-2, 8-3-1, 10-1-1 and 3-1). Location of well characterized regulators in these ILs helped to filter potential new key genes involved in drought stress tolerance. Obtained results suggests us our approaches could be viable for narrowing down potential candidates involved in creating interspecific variation in secondary metabolite content and at the level of fruit ripening.
The concurrent performance of cognitive and postural tasks is particularly impaired in old adults and associated with an increased risk of falls. Biological aging of the cognitive and postural control system appears to be responsible for increased cognitive-motor interference effects. We examined neural and behavioral markers of motor-cognitive dual-task performance in young and old adults performing spatial one-back working memory single and dual tasks during semitandem stance. On the neural level, we used EEG to test for age-related modulations in the frequency domain related to cognitive-postural task load. Twenty-eight healthy young and 30 old adults participated in this study. The tasks included a postural single task, a cognitive-postural dual task, and a cognitive-postural triple task (cognitive dual-task with postural demands). Postural sway (i.e., total center of pressure displacements) was recorded in semistance position on an unstable surface that was placed on top of a force plate while performing cognitive tasks. Neural activation was recorded using a 64-channel mobile EEG system. EEG frequencies were attenuated by the baseline postural single-task condition and demarcated in nine Regions-of-Interest (ROIs), i.e., anterior, central, posterior, over the cortical midline, and both hemispheres. Our findings revealed impaired cognitive dual-task performance in old compared to young participants in the form of significantly lower cognitive performance in the triple-task condition. Furthermore, old adults compared with young adults showed significantly larger postural sway, especially in cognitive-postural task conditions. With respect to EEG frequencies, young compared to old participants showed significantly lower alpha-band activity in cognitive-cognitive-postural triple-task conditions compared with cognitive-postural dual tasks. In addition, with increasing task difficulty, we observed synchronized theta and delta frequencies, irrespective of age. Taskdependent alterations of the alpha frequency band were most pronounced over frontal and central ROIs, while alterations of the theta and delta frequency bands were found in frontal, central, and posterior ROIs. Theta and delta synchronization exhibited a decrease from anterior to posterior regions. For old adults, task difficulty was reflected by theta synchronization in the posterior ROI. For young adults, it was reflected by alpha desynchronization in bilateral anterior ROIs. In addition, we could not identify any effects of task difficulty and age on the beta frequency band. Our results shed light on age-related cognitive and postural declines and how they interact. Modulated alpha frequencies during high cognitive-postural task demands in young but not old adults might be reflective of a constrained neural adaptive potential in old adults. Future studies are needed to elucidate associations between the identified age-related performance decrements with task difficulty and changes in brain activity.
Background
Postoperative delirium is a common disorder in older adults that is associated with higher morbidity and mortality, prolonged cognitive impairment, development of dementia, higher institutionalization rates, and rising healthcare costs. The probability of delirium after surgery increases with patients’ age, with pre-existing cognitive impairment, and with comorbidities, and its diagnosis and treatment is dependent on the knowledge of diagnostic criteria, risk factors, and treatment options of the medical staff. In this study, we will investigate whether a cross-sectoral and multimodal intervention for preventing delirium can reduce the prevalence of delirium and postoperative cognitive decline (POCD) in patients older than 70 years undergoing elective surgery. Additionally, we will analyze whether the intervention is cost-effective.
Methods
The study will be conducted at five medical centers (with two or three surgical departments each) in the southwest of Germany. The study employs a stepped-wedge design with cluster randomization of the medical centers. Measurements are performed at six consecutive points: preadmission, preoperative, and postoperative with daily delirium screening up to day 7 and POCD evaluations at 2, 6, and 12 months after surgery. Recruitment goals are to enroll 1500 patients older than 70 years undergoing elective operative procedures (cardiac, thoracic, vascular, proximal big joints and spine, genitourinary, gastrointestinal, and general elective surgery procedures.
Discussion
Results of the trial should form the basis of future standards for preventing delirium and POCD in surgical wards. Key aims are the improvement of patient safety and quality of life, as well as the reduction of the long-term risk of conversion to dementia. Furthermore, from an economic perspective, we expect benefits and decreased costs for hospitals, patients, and healthcare insurances.
Trial registration
German Clinical Trials Register, DRKS00013311. Registered on 10 November 2017.
The concurrent performance of cognitive and postural tasks is particularly impaired in old adults and associated with an increased risk of falls. Biological aging of the cognitive and postural control system appears to be responsible for increased cognitive-motor interference effects. We examined neural and behavioral markers of motor-cognitive dual-task performance in young and old adults performing spatial one-back working memory single and dual tasks during semitandem stance. On the neural level, we used EEG to test for age-related modulations in the frequency domain related to cognitive-postural task load. Twenty-eight healthy young and 30 old adults participated in this study. The tasks included a postural single task, a cognitive-postural dual task, and a cognitive-postural triple task (cognitive dual-task with postural demands). Postural sway (i.e., total center of pressure displacements) was recorded in semistance position on an unstable surface that was placed on top of a force plate while performing cognitive tasks. Neural activation was recorded using a 64-channel mobile EEG system. EEG frequencies were attenuated by the baseline postural single-task condition and demarcated in nine Regions-of-Interest (ROIs), i.e., anterior, central, posterior, over the cortical midline, and both hemispheres. Our findings revealed impaired cognitive dual-task performance in old compared to young participants in the form of significantly lower cognitive performance in the triple-task condition. Furthermore, old adults compared with young adults showed significantly larger postural sway, especially in cognitive-postural task conditions. With respect to EEG frequencies, young compared to old participants showed significantly lower alpha-band activity in cognitive-cognitive-postural triple-task conditions compared with cognitive-postural dual tasks. In addition, with increasing task difficulty, we observed synchronized theta and delta frequencies, irrespective of age. Taskdependent alterations of the alpha frequency band were most pronounced over frontal and central ROIs, while alterations of the theta and delta frequency bands were found in frontal, central, and posterior ROIs. Theta and delta synchronization exhibited a decrease from anterior to posterior regions. For old adults, task difficulty was reflected by theta synchronization in the posterior ROI. For young adults, it was reflected by alpha desynchronization in bilateral anterior ROIs. In addition, we could not identify any effects of task difficulty and age on the beta frequency band. Our results shed light on age-related cognitive and postural declines and how they interact. Modulated alpha frequencies during high cognitive-postural task demands in young but not old adults might be reflective of a constrained neural adaptive potential in old adults. Future studies are needed to elucidate associations between the identified age-related performance decrements with task difficulty and changes in brain activity.
We combine ultrafast X-ray diffraction (UXRD) and time-resolved Magneto-Optical Kerr Effect (MOKE) measurements to monitor the strain pulses in laser-excited TbFe2/Nb heterostructures. Spatial separation of the Nb detection layer from the laser excitation region allows for a background-free characterization of the laser-generated strain pulses. We clearly observe symmetric bipolar strain pulses if the excited TbFe2 surface terminates the sample and a decomposition of the strain wavepacket into an asymmetric bipolar and a unipolar pulse, if a SiO2 glass capping layer covers the excited TbFe2 layer. The inverse magnetostriction of the temporally separated unipolar strain pulses in this sample leads to a MOKE signal that linearly depends on the strain pulse amplitude measured through UXRD. Linear chain model simulations accurately predict the timing and shape of UXRD and MOKE signals that are caused by the strain reflections from multiple interfaces in the heterostructure.
In animals and humans, behavior can be influenced by irrelevant stimuli, a phenomenon called Pavlovian-to-instrumental transfer (PIT). In subjects with substance use disorder, PIT is even enhanced with functional activation in the nucleus accumbens (NAcc) and amygdala. While we observed enhanced behavioral and neural PIT effects in alcohol-dependent subjects, we here aimed to determine whether behavioral PIT is enhanced in young men with high-risk compared to low-risk drinking and subsequently related functional activation in an a-priori region of interest encompassing the NAcc and amygdala and related to polygenic risk for alcohol consumption. A representative sample of 18-year old men (n = 1937) was contacted: 445 were screened, 209 assessed: resulting in 191 valid behavioral, 139 imaging and 157 genetic datasets. None of the subjects fulfilled criteria for alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-IV-TextRevision (DSM-IV-TR). We measured how instrumental responding for rewards was influenced by background Pavlovian conditioned stimuli predicting action-independent rewards and losses. Behavioral PIT was enhanced in high-compared to low-risk drinkers (b = 0.09, SE = 0.03, z = 2.7, p < 0.009). Across all subjects, we observed PIT-related neural blood oxygen level-dependent (BOLD) signal in the right amygdala (t = 3.25, p(SVC) = 0.04, x = 26, y = -6, z = -12), but not in NAcc. The strength of the behavioral PIT effect was positively correlated with polygenic risk for alcohol consumption (r(s) = 0.17, p = 0.032). We conclude that behavioral PIT and polygenic risk for alcohol consumption might be a biomarker for a subclinical phenotype of risky alcohol consumption, even if no drug-related stimulus is present. The association between behavioral PIT effects and the amygdala might point to habitual processes related to out PIT task. In non-dependent young social drinkers, the amygdala rather than the NAcc is activated during PIT; possible different involvement in association with disease trajectory should be investigated in future studies.
BACKGROUND: Pavlovian-to-instrumental transfer (PIT) describes the influence of conditioned stimuli on instrumental behaviors and is discussed as a key process underlying substance abuse. Here, we tested whether neural responses during alcohol-related PIT predict future relapse in alcohol-dependent patients and future drinking behavior in adolescents. METHODS: Recently detoxified alcohol-dependent patients (n = 52) and young adults without dependence (n = 136) underwent functional magnetic resonance imaging during an alcohol-related PIT paradigm, and their drinking behavior was assessed in a 12-month follow-up. To predict future drinking behavior from PIT activation patterns, we used a multivoxel classification scheme based on linear support vector machines. RESULTS: When training and testing the classification scheme in patients, PIT activation patterns predicted future relapse with 71.2% accuracy. Feature selection revealed that classification was exclusively based on activation patterns in medial prefrontal cortex. To probe the generalizability of this functional magnetic resonance imaging-based prediction of future drinking behavior, we applied the support vector machine classifier that had been trained on patients to PIT functional magnetic resonance imaging data from adolescents. An analysis of cross-classification predictions revealed that those young social drinkers who were classified as abstainers showed a greater reduction in alcohol consumption at 12-month follow-up than those classified as relapsers (Delta = -24.4 +/- 6.0 g vs. -5.7 +/- 3.6 g; p = .019). CONCLUSIONS: These results suggest that neural responses during PIT could constitute a generalized prognostic marker for future drinking behavior in established alcohol use disorder and in at-risk states.
Compulsive behaviors (e.g., addiction) can be viewed as an aberrant decision process where inflexible reactions automatically evoked by stimuli (habit) take control over decision making to the detriment of a more flexible (goal-oriented) behavioral learning system. These behaviors are thought to arise from learning algorithms known as "model-based" and "model-free" reinforcement learning. Gambling disorder, a form of addiction without the confound of neurotoxic effects of drugs, showed impaired goal-directed control but the way in which problem gamblers (PG) orchestrate model-based and model-free strategies has not been evaluated. Forty-nine PG and 33 healthy participants (CP) completed a two-step sequential choice task for which model-based and model-free learning have distinct and identifiable trial-by-trial learning signatures. The influence of common psychopathological comorbidities on those two forms of learning were investigated. PG showed impaired model-based learning, particularly after unrewarded outcomes. In addition, PG exhibited faster reaction times than CP following unrewarded decisions. Troubled mood, higher impulsivity (i.e., positive and negative urgency) and current and chronic stress reported via questionnaires did not account for those results. These findings demonstrate specific reinforcement learning and decision-making deficits in behavioral addiction that advances our understanding and may be important dimensions for designing effective interventions.
Evaluation of technology-based interventions for informal caregivers of patients with dementia
(2019)
Objective: The aim of this study was to estimate the efficacy of technology-based interventions for informal caregivers of people with dementia (PWD). Methods: PubMed, PsycINFO, and Cochrane Library databases were searched in August 2018, with no restrictions in language or publication date. Two independent reviewers identified 33 eligible randomized controlled trials (RCTs) conducting a technology-based intervention for informal carers of PWD. Meta-analyses for the outcome measures caregiver depression and caregiver burden were conducted with subgroup analyses according to mode of delivery (telephone, computer/web-based, combined interventions). To assess methodologic quality, the Cochrane risk-of-bias assessment was rated. Results: Meta-analyses revealed a small but significant postintervention effect of technology-based interventions for caregiver depression and caregiver burden. Combined interventions showed the strongest effects. Conclusion: Technology-based interventions have the potential to support informal caregivers of PWD. Because of advantages such as high flexibility and availability, technology-based interventions provide a promising alternative compared with "traditional services," e.g., those for people living in rural areas. More high-quality RCTs for specific caregiver groups are needed.
Effects of Aerobic and Resistance Exercise on Cardiovascular Parameters for People Living With HIV
(2019)
People living with HIV (PLWH) have limited exercise capacity because of anemia, neuromuscular disorders, and pulmonary limitations. We used a meta-analysis to examine the effect of aerobic and resistance exercise alone and in combination on cardiovascular parameters. Subgroup meta-analyses were conducted and long-term effects of exercise were investigated. A systematic literature search was conducted up to July/August 2017. The Physiotherapy Evidence Database-scale was used to rate quality and assess the risk of bias on the papers. Standardized mean differences (SMDs) were calculated to assess the effect of exercise. Posttreatment comparison between the exercise and control groups revealed moderate and large effect sizes in favor of the intervention group for VO2max (SMD50.66, p < .0001) and the 6-minute walk test (SMD = 1.11, p = .0001). Exercise had a positive effect on cardiovascular parameters in PLWH. Exercise can be a prevention factor for PLWH dealing with multiple comorbidities.
Background
Postoperative delirium is a common disorder in older adults that is associated with higher morbidity and mortality, prolonged cognitive impairment, development of dementia, higher institutionalization rates, and rising healthcare costs. The probability of delirium after surgery increases with patients’ age, with pre-existing cognitive impairment, and with comorbidities, and its diagnosis and treatment is dependent on the knowledge of diagnostic criteria, risk factors, and treatment options of the medical staff. In this study, we will investigate whether a cross-sectoral and multimodal intervention for preventing delirium can reduce the prevalence of delirium and postoperative cognitive decline (POCD) in patients older than 70 years undergoing elective surgery. Additionally, we will analyze whether the intervention is cost-effective.
Methods
The study will be conducted at five medical centers (with two or three surgical departments each) in the southwest of Germany. The study employs a stepped-wedge design with cluster randomization of the medical centers. Measurements are performed at six consecutive points: preadmission, preoperative, and postoperative with daily delirium screening up to day 7 and POCD evaluations at 2, 6, and 12 months after surgery. Recruitment goals are to enroll 1500 patients older than 70 years undergoing elective operative procedures (cardiac, thoracic, vascular, proximal big joints and spine, genitourinary, gastrointestinal, and general elective surgery procedures.
Discussion
Results of the trial should form the basis of future standards for preventing delirium and POCD in surgical wards. Key aims are the improvement of patient safety and quality of life, as well as the reduction of the long-term risk of conversion to dementia. Furthermore, from an economic perspective, we expect benefits and decreased costs for hospitals, patients, and healthcare insurances.
Trial registration
German Clinical Trials Register, DRKS00013311. Registered on 10 November 2017.
The role of perceived need support from exercise professionals in improving mental health was examined in a sample of older adults, thereby validating the short Health Care Climate Questionnaire. A total of 491 older people (M = 72.68 years; SD = 5.47) attending a health exercise program participated in this study. Cronbach's alpha was found to be high (alpha = .90). Satisfaction with the exercise professional correlated moderately with the short Health Care Climate Questionnaire mean value (r = .38; p < .01). The mediator analyses yielded support for the self-determination theory process model in older adults by showing both basic need satisfaction and frustration as mediating variables between perceived autonomy support and depressive symptoms. The short Health Care Climate Questionnaire is an economical instrument for assessing basic need satisfaction provided by the exercise therapist from the participant's perspective. Furthermore, this cross-sectional study supported the link from coaching style to the satisfaction/frustration of basic psychological needs, which in turn, predicted mental health. Analyses of criterion validity suggest a revision of the construct by integrating need frustration.
Background Aversive stimuli in the environment influence human actions. This includes valence-dependent influences on action selection, e.g., increased avoidance but decreased approach behavior. However, it is yet unclear how aversive stimuli interact with complex learning and decision-making in the reward and avoidance domain. Moreover, the underlying computational mechanisms of these decision-making biases are unknown. Methods To elucidate these mechanisms, 54 healthy young male subjects performed a two-step sequential decision-making task, which allows to computationally model different aspects of learning, e.g., model-free, habitual, and model-based, goal-directed learning. We used a within-subject design, crossing task valence (reward vs. punishment learning) with emotional context (aversive vs. neutral background stimuli). We analyzed choice data, applied a computational model, and performed simulations. Results Whereas model-based learning was not affected, aversive stimuli interacted with model-free learning in a way that depended on task valence. Thus, aversive stimuli increased model-free avoidance learning but decreased model-free reward learning. The computational model confirmed this effect: the parameter lambda that indicates the influence of reward prediction errors on decision values was increased in the punishment condition but decreased in the reward condition when aversive stimuli were present. Further, by using the inferred computational parameters to simulate choice data, our effects were captured. Exploratory analyses revealed that the observed biases were associated with subclinical depressive symptoms. Conclusion Our data show that aversive environmental stimuli affect complex learning and decision-making, which depends on task valence. Further, we provide a model of the underlying computations of this affective modulation. Finally, our finding of increased decision-making biases in subjects reporting subclinical depressive symptoms matches recent reports of amplified Pavlovian influences on action selection in depression and suggests a potential vulnerability factor for mood disorders. We discuss our findings in the light of the involvement of the neuromodulators serotonin and dopamine.
Purpose: Postoperative cognitive dysfunction (POCD) appears in up to 30% of patients suffering from postoperative delirium (POD). Both are associated with higher mortality and postoperative complications, prolonged hospital stays, and increased costs. Multi-modal models with pre-admission risk reduction counselling, perioperative monitoring, and training of multidisciplinary patient care providers have been shown to decrease the prevalence of both. The aim of our study is to understand how far those measures are known and implemented in routine care and to detect potential gaps in the current practice regarding risk communication and information flow between involved caregivers for patients at risk for POD/POCD. Patients and Methods: As part of a multicenter study, seven semi-structured focus group (FG) discussions with nurses and physicians from tertiary care hospitals (surgery, anesthesiology, and orthopedics, n=31) and general practitioners (GPs) in private practice (n=7) were performed. Transcribed discussions were analyzed using qualitative content analysis. Results: POD is present above all in the daily work of nurses, whereas physicians do not perceive it as a relevant problem. Physicians report that no regular risk assessment or risk communication was performed prior to elective surgery. Information about POD often gets lost during hand-offs and is not regularly reported in discharge letters. Thus, persisting cognitive dysfunction is often missed. The importance of standardized documentation and continuous education concerning risks, screening, and treatment was emphasized. The often-suggested pre-OP medication adjustment was seen as less important; in contrast, avoiding withdrawal was regarded as far more important. Conclusion: Altogether, it seems that standards and available best practice concepts are rarely implemented. In contrast to physicians, nurses are highly aware of delirium and ask for standardized procedures and more responsibility. Therefore, raising awareness regarding risks, screening tools, and effective preventive measures for POD/POCD seems an urgent goal. Nurses should have a central role in coordination and care of POD to prevent the risk for POCD.
In animals and humans, behavior can be influenced by irrelevant stimuli, a phenomenon called Pavlovian-to-instrumental transfer (PIT). In subjects with substance use disorder, PIT is even enhanced with functional activation in the nucleus accumbens (NAcc) and amygdala. While we observed enhanced behavioral and neural PIT effects in alcohol-dependent subjects, we here aimed to determine whether behavioral PIT is enhanced in young men with high-risk compared to low-risk drinking and subsequently related functional activation in an a-priori region of interest encompassing the NAcc and amygdala and related to polygenic risk for alcohol consumption. A representative sample of 18-year old men (n = 1937) was contacted: 445 were screened, 209 assessed: resulting in 191 valid behavioral, 139 imaging and 157 genetic datasets. None of the subjects fulfilled criteria for alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-IV-TextRevision (DSM-IV-TR). We measured how instrumental responding for rewards was influenced by background Pavlovian conditioned stimuli predicting action-independent rewards and losses. Behavioral PIT was enhanced in high-compared to low-risk drinkers (b = 0.09, SE = 0.03, z = 2.7, p < 0.009). Across all subjects, we observed PIT-related neural blood oxygen level-dependent (BOLD) signal in the right amygdala (t = 3.25, p(SVC) = 0.04, x = 26, y = -6, z = -12), but not in NAcc. The strength of the behavioral PIT effect was positively correlated with polygenic risk for alcohol consumption (r(s) = 0.17, p = 0.032). We conclude that behavioral PIT and polygenic risk for alcohol consumption might be a biomarker for a subclinical phenotype of risky alcohol consumption, even if no drug-related stimulus is present. The association between behavioral PIT effects and the amygdala might point to habitual processes related to out PIT task. In non-dependent young social drinkers, the amygdala rather than the NAcc is activated during PIT; possible different involvement in association with disease trajectory should be investigated in future studies.
The evolution of the radiation belts in L-shell (L), energy (E), and equatorial pitch angle (alpha(0)) is analyzed during the calm 11-day interval (4-15 March) following the 1 March 2013 storm. Magnetic Electron and Ion Spectrometer (MagEIS) observations from Van Allen Probes are interpreted alongside 1D and 3D Fokker-Planck simulations combined with consistent event-driven scattering modeling from whistler mode hiss waves. Three (L, E, alpha(0)) regions persist through 11 days of hiss wave scattering; the pitch angle-dependent inner belt core (L similar to <2.2 and E < 700 keV), pitch angle homogeneous outer belt low-energy core (L > similar to 5 and E similar to < 100 keV), and a distinct pocket of electrons (L similar to [4.5, 5.5] and E similar to [0.7, 2] MeV). The pitch angle homogeneous outer belt is explained by the diffusion coefficients that are roughly constant for alpha(0) similar to <60 degrees, E > 100 keV, 3.5 < L < L-pp similar to 6. Thus, observed unidirectional flux decays can be used to estimate local pitch angle diffusion rates in that region. Top-hat distributions are computed and observed at L similar to 3-3.5 and E = 100-300 keV.
Data assimilation aims to blend incomplete and inaccurate data with physics-based dynamical models. In the Earth's radiation belts, it is used to reconstruct electron phase space density, and it has become an increasingly important tool in validating our current understanding of radiation belt dynamics, identifying new physical processes, and predicting the near-Earth hazardous radiation environment. In this study, we perform reanalysis of the sparse measurements from four spacecraft using the three-dimensional Versatile Electron Radiation Belt diffusion model and a split-operator Kalman filter over a 6-month period from 1 October 2012 to 1 April 2013. In comparison to previous works, our 3-D model accounts for more physical processes, namely, mixed pitch angle-energy diffusion, scattering by Electromagnetic Ion Cyclotron waves, and magnetopause shadowing. We describe how data assimilation, by means of the innovation vector, can be used to account for missing physics in the model. We use this method to identify the radial distances from the Earth and the geomagnetic conditions where our model is inconsistent with the measured phase space density for different values of the invariants mu and K. As a result, the Kalman filter adjusts the predictions in order to match the observations, and we interpret this as evidence of where and when additional source or loss processes are active. The current work demonstrates that 3-D data assimilation provides a comprehensive picture of the radiation belt electrons and is a crucial step toward performing reanalysis using measurements from ongoing and future missions.
Ziel der Studie Erfassung der Strukturen zur Frühdiagnostik von Demenzen an Krankenhäusern in Deutschland.
Methodik Fragebogenerhebung.
Ergebnisse 14 % von 1758 kontaktierten Einrichtungen antworteten. 52 % berichteten über ein entsprechendes Angebot, zum großen Teil mit leitlinienorientierten Verfahren, wie Liquordiagnostik. Das Diagnosespektrum umfasste zu 46 % Demenzen und zu 41 % Diagnosen der leichten oder subjektiven kognitiven Störung.
Schlussfolgerung Leitlinienbasierte Diagnostik und Früherkennungskonzepte sind in Gedächtnisambulanzen weitgehend etabliert.
Stress plays a key role in modulating addictive behavior and can cause relapse following periods of abstinence. Common effects of stress and alcohol on the dopaminergic system have been suggested, although the precise mechanisms are unclear. Here, we investigated 20 detoxified alcohol-dependent patients and 19 matched healthy controls and assessed striatal D2/D3 availability using [F-18]-fallypride positron emission tomography and stressful life events. We found a strong association between striatal D2/D3 availability and stress in patients, but not in healthy controls. Interestingly, we found increased D2/D3 receptor availability in patients with higher stress levels. This mirrors complex interactions between stress and alcohol intake in animal studies and emphasizes the importance to investigate stress exposure in neurobiological studies of addiction.
We measure the transient strain profile in a nanoscale multilayer system composed of yttrium, holmium, and niobium after laser excitation using ultrafast x-ray diffraction. The strain propagation through each layer is determined by transient changes in the material-specific Bragg angles. We experimentally derive the exponentially decreasing stress profile driving the strain wave and show that it closely matches the optical penetration depth. Below the Neel temperature of Ho, the optical excitation triggers negative thermal expansion, which is induced by a quasi-instantaneous contractive stress and a second contractive stress contribution increasing on a 12-ps timescale. These two timescales were recently measured for the spin disordering in Ho [Rettig et al., Phys. Rev. Lett. 116, 257202 (2016)]. As a consequence, we observe an unconventional bipolar strain pulse with an inverted sign traveling through the heterostructure.
General intelligence has a substantial genetic background in children, adolescents, and adults, but environmental factors also strongly correlate with cognitive performance as evidenced by a strong (up to one SD) increase in average intelligence test results in the second half of the previous century. This change occurred in a period apparently too short to accommodate radical genetic changes. It is highly suggestive that environmental factors interact with genotype by possible modification of epigenetic factors that regulate gene expression and thus contribute to individual malleability. This modification might as well be reflected in recent observations of an association between dopamine-dependent encoding of reward prediction errors and cognitive capacity, which was modulated by adverse life events.
Fold and thrust belts are characteristic features of collisional orogen that grow laterally through time by deforming the upper crust in response to stresses caused by convergence. The deformation propagation in the upper crust is accommodated by shortening along major folds and thrusts. The formation of these structures is influenced by the mechanical strength of décollements, basement architecture, presence of preexisting structures and taper of the wedge. These factors control not only the sequence of deformation but also cause differences in the structural style.
The Himalayan fold and thrust belt exhibits significant differences in the structural style from east to west. The external zone of the Himalayan fold and thrust belt, also called the Subhimalaya, has been extensively studied to understand the temporal development and differences in the structural style in Bhutan, Nepal and India; however, the Subhimalaya in Pakistan remains poorly studied. The Kohat and Potwar fold and thrust belts (herein called Kohat and Potwar) represent the Subhimalaya in Pakistan. The Main Boundary Thrust (MBT) marks the northern boundary of both Kohat and Potwar, showing that these belts are genetically linked to foreland-vergent deformation within the Himalayan orogen, despite the pronounced contrast in structural style. This contrast becomes more pronounced toward south, where the active strike-slip Kalabagh Fault Zone links with the Kohat and Potwar range fronts, known as the Surghar Range and the Salt Range, respectively. The Surghar and Salt Ranges developed above the Surghar Thrust (SGT) and Main Frontal Thrust (MFT). In order to understand the structural style and spatiotemporal development of the major structures in Kohat and Potwar, I have used structural modeling and low temperature thermochronolgy methods in this study. The structural modeling is based on construction of balanced cross-sections by integrating surface geology, seismic reflection profiles and well data. In order to constrain the timing and magnitude of exhumation, I used apatite (U-Th-Sm)/He (AHe) and apatite fission track (AFT) dating. The results obtained from both methods are combined to document the Paleozoic to Recent history of Kohat and Potwar.
The results of this research suggest two major events in the deformation history. The first major deformation event is related to Late Paleozoic rifting associated with the development of the Neo-Tethys Ocean. The second major deformation event is related to the Late Miocene to Pliocene development of the Himalayan fold and thrust belt in the Kohat and Potwar. The Late Paleozoic rifting is deciphered by inverse thermal modelling of detrital AFT and AHe ages from the Salt Range. The process of rifting in this area created normal faulting that resulted in the exhumation/erosion of Early to Middle Paleozoic strata, forming a major unconformity between Cambrian and Permian strata that is exposed today in the Salt Range. The normal faults formed in Late Paleozoic time played an important role in localizing the Miocene-Pliocene deformation in this area. The combination of structural reconstructions and thermochronologic data suggest that deformation initiated at 15±2 Ma on the SGT ramp in the southern part of Kohat. The early movement on the SGT accreted the foreland into the Kohat deforming wedge, forming the range front. The development of the MBT at 12±2 Ma formed the northern boundary of Kohat and Potwar. Deformation propagated south of the MBT in the Kohat on double décollements and in the Potwar on a single basal décollement. The double décollement in the Kohat adopted an active roof-thrust deformation style that resulted in the disharmonic structural style in the upper and lower parts of the stratigraphic section. Incremental shortening resulted in the development of duplexes in the subsurface between two décollements and imbrication above the roof thrust. Tectonic thickening caused by duplexes resulted in cooling and exhumation above the roof thrust by removal of a thick sequence of molasse strata. The structural modelling shows that the ramps on which duplexes formed in Kohat continue as tip lines of fault propagation folds in the Potwar. The absence of a double décollement in the Potwar resulted in the preservation of a thick sequence of molasse strata there. The temporal data suggest that deformation propagated in-sequence from ~ 8 to 3 Ma in the northern part of Kohat and Potwar; however, internal deformation in the Kohat was more intense, probably required for maintaining a critical taper after a significant load was removed above the upper décollement. In the southern part of Potwar, a steeper basement slope (β≥3°) and the presence of salt at the base of the stratigraphic section allowed for the complete preservation of the stratigraphic wedge, showcased by very little internal deformation. Activation of the MFT at ~4 Ma allowed the Salt Range to become the range front of the Potwar. The removal of a large amount of molasse strata above the MFT ramp enhanced the role of salt in shaping the structural style of the Salt Range and Kalabagh Fault Zone. Salt accumulation and migration resulted in the formation of normal faults in both areas. Salt migration in the Kalabagh fault zone has triggered out-of-sequence movement on ramps in the Kohat.
The amount of shortening calculated between the MBT and the SGT in Kohat is 75±5 km and between the MBT and the MFT in Potwar is 65±5 km. A comparable amount of shortening is accommodated in the Kohat and Potwar despite their different widths: 70 km Kohat and 150 km Potwar. In summary, this research suggests that deformation switched between different structures during the last ~15 Ma through different modes of fault propagation, resulting in different structural styles and the out-of-sequence development of Kohat and Potwar.
The in‐depth understanding of charge carrier photogeneration and recombination mechanisms in organic solar cells is still an ongoing effort. In donor:acceptor (bulk) heterojunction organic solar cells, charge photogeneration and recombination are inter‐related via the kinetics of charge transfer states—being singlet or triplet states. Although high‐charge‐photogeneration quantum yields are achieved in many donor:acceptor systems, only very few systems show significantly reduced bimolecular recombination relative to the rate of free carrier encounters, in low‐mobility systems. This is a serious limitation for the industrialization of organic solar cells, in particular when aiming at thick active layers. Herein, a meta‐analysis of the device performance of numerous bulk heterojunction organic solar cells is presented for which field‐dependent photogeneration, charge carrier mobility, and fill factor are determined. Herein, a “spin‐related factor” that is dependent on the ratio of back electron transfer of the triplet charge transfer (CT) states to the decay rate of the singlet CT states is introduced. It is shown that this factor links the recombination reduction factor to charge‐generation efficiency. As a consequence, it is only in the systems with very efficient charge generation and very fast CT dissociation that free carrier recombination is strongly suppressed, regardless of the spin‐related factor.
Die Zukunft der Medizin
(2019)
Die Medizin im 21. Jahrhundert wird sich so schnell verändern wie nie zuvor – und mit ihr das Gesundheitswesen. Bahnbrechende Entwicklungen in Forschung und Digitalisierung werden die Auswertung und Nutzung riesiger Datenmengen in kurzer Zeit ermöglichen. Das wird unsere Kenntnisse über Gesundheit und gesund sein, sowie über die Entstehung, Prävention und Heilung von Krankheiten vollkommen verändern. Gleichzeitig wird sich die Art und Weise, wie Medizin praktiziert wird, fundamental verändern. Das Selbstverständnis nahezu aller Akteure wird sich rasch weiterentwickeln müssen. Das Gesundheitssystem wird in allen Bereichen umgebaut und teilweise neu erfunden werden. Digitale Transformation, Personalisierung und Prävention sind die Treiber der neuen Medizin.
Deutschland darf den Anschluss nicht verpassen. Im Vergleich mit anderen Ländern ist das deutsche Gesundheitswesen in vielen Punkten bedrohlich rückständig und fragmentiert. Um die Medizin und das Gesundheitswesen in Deutschland langfristig zukunftsfest zu machen, bedarf es vieler Anstrengungen – vor allem aber Offenheit gegenüber Veränderungen, sowie einen regulatorischen Rahmen, der ermöglicht, dass die medizinischen und digitalen Innovationen beim Patienten ankommen.
DIE ZUKUNFT DER MEDIZIN beschreibt Entwicklungen und Technologien, die die Medizin und das Gesundheitswesen im 21. Jahrhundert prägen werden. Das Buch informiert über die zum Teil dramatischen, disruptiven Innovationen in der Forschung, die durch Big Data, Künstliche Intelligenz und Robotik möglich werden.
Die Autoren sind führende Vordenker ihres Fachs und beschreiben aus langjähriger Erfahrung im In- und Ausland zukünftige Entwicklungen, die jetzt bereits greifbar sind.
Wendepunkt für Gesundheit
(2019)
The Baringo-Tugen-Barsemoi 2013 drillcore (BTB13), acquired as part of the Hominin Sites and Paleolakes Drilling Project, recovered 228 m of fluviolacustrine sedimentary rocks and tuffs spanning a similar to 3.29-2.56 Ma interval of the highly fossiliferous and hominin-bearing Chemeron Formation, Tugen Hills, Kenya. Here we present a Bayesian stratigraphic age model for the core employing chronostratigraphic control points derived from Ar-40/Ar-39 dating of tuffs from core and outcrop, Ar-40/Ar-39 age calibration of related outcrop diatomaceous units, and core magnetostratigraphy. The age model reveals three main intervals with distinct sediment accumulation rates: an early rapid phase from 3.2 to 2.9 Ma; a relatively slow phase from 2.9 to 2.7 Ma; and the highest rate of accumulation from 2.7 to 2.6 Ma. The intervals of rapid accumulation correspond to periods of high Earth orbital eccentricity, whereas the slow accumulation interval corresponds to low eccentricity at 2.9-2.7 Ma, suggesting that astronomically mediated climate processes may be responsible for the observed changes in sediment accumulation rate. Lacustrine transgression-regression events, as delineated using sequence stratigraphy, dominantly operate on precession scale, particularly within the high eccentricity periods. A set of erosively based fluvial conglomerates correspond to the 2.9-2.7 Ma interval, which could be related to either the depositional response to low eccentricity or to the development of unconformities due to local tectonic activity. Age calibration of core magnetic susceptibility and gamma density logs indicates a close temporal correspondence between a shift from high- to low-frequency signal variability at similar to 3 Ma, approximately coincident the end of the mid-Piacenzian Warm Period, and the beginning of the cooling of world climate leading to the initiation of Northern Hemispheric glaciation c. 2.7 Ma. BTB13 and the Baringo Basin records may thus provide evidence of a connection between high-latitude glaciation and equatorial terrestrial climate toward the end of the Pliocene.
§ 217 StGB reiht sich in andere kriminalpolitische Projekte des Gesetzgebers ein, die sich dem Einwand des fehlenden Rechtsgutsbezugs ausgesetzt sehen.
Die Untersuchung zeigt auf, dass der Gesetzgeber mit der Einführung des § 217 StGB den Zweck des Strafrechts als „ultima-ratio“ des Rechtsgüterschutzes verfehlt hat. Auch wenn er mit der Norm den Schutz von Leben und Autonomie bezweckt hat, ist ihm die Umsetzung des Schutzes dieser Rechtsgüter nicht gelungen. Die Vorschrift dient vielmehr dem Zweck der Verhinderung einer Suizidkultur. Nach der systemkritischen Rechtsgutslehre kann ein solcher „moralischer“ Zweck jedoch kein strafrechtlich zu schützendes Rechtsgut darstellen.
Da eine Aufhebung der Vorschrift durch das Bundesverfassungsgericht wenig wahrscheinlich erscheint, schließt sich der Rechtsgutsdiskussion eine praxisorientierte Auslegung der Norm unter dem Gesichtspunkt des überindividuellen Zwecks, der Verhinderung einer Suizidkultur, an.
Paleogene evolution and demise of the proto-Paratethys Sea in Central Asia (Tarim and Tajik basins)
(2019)
The proto-Paratethys Sea covered a vast area extending from the Mediterranean Tethys to the Tarim Basin in western China during Cretaceous and early Paleogene. Climate modelling and proxy studies suggest that Asian aridification has been governed by westerly moisture modulated by fluctuations of the proto-Paratethys Sea. Transgressive and regressive episodes of the proto-Paratethys Sea have been previously recognized but their timing, extent and depositional environments remain poorly constrained. This hampers understanding of their driving mechanisms (tectonic and/or eustatic) and their contribution to Asian aridification. Here, we present a new chronostratigraphic framework based on biostratigraphy and magnetostratigraphy as well as a detailed palaeoenvironmental analysis for the Paleogene proto-Paratethys Sea incursions in the Tajik and Tarim basins. This enables us to identify the major drivers of marine fluctuations and their potential consequences on Asian aridification. A major regional restriction event, marked by the exceptionally thick (<= 400 m) shelf evaporites is assigned a Danian-Selandian age (ca. 63-59 Ma) in the Aertashi Formation. This is followed by the largest recorded proto-Paratethys Sea incursion with a transgression estimated as early Thanetian (ca. 59-57 Ma) and a regression within the Ypresian (ca. 53-52 Ma), both within the Qimugen Formation. The transgression of the next incursion in the Kalatar and Wulagen formations is now constrained as early Lutetian (ca. 47-46 Ma), whereas its regression in the Bashibulake Formation is constrained as late Lutetian (ca. 41 Ma) and is associated with a drastic increase in both tectonic subsidence and basin infilling. The age of the final and least pronounced sea incursion restricted to the westernmost margin of the Tarim Basin is assigned as Bartonian-Priabonian (ca. 39.7-36.7 Ma). We interpret the long-term westward retreat of the proto-Paratethys Sea starting at ca. 41 Ma to be associated with far-field tectonic effects of the Indo-Asia collision and Pamir/Tibetan plateau uplift. Short-term eustatic sea level transgressions are superimposed on this long-term regression and seem coeval with the transgression events in the other northern Peri-Tethyan sedimentary provinces for the 1st and 2nd sea incursions. However, the 3rd sea incursion is interpreted as related to tectonism. The transgressive and regressive intervals of the proto-Paratethys Sea correlate well with the reported humid and arid phases, respectively in the Qaidam and Xining basins, thus demonstrating the role of the proto-Paratethys Sea as an important moisture source for the Asian interior and its regression as a contributor to Asian aridification.
The northward indentation of the Pamir salient into the Tarim basin at the western syntaxis of the India-Asia collision zone is the focus of controversial models linking lithospheric to surface and atmospheric processes. Here we report on tectonic events recorded in the most complete and best-dated sedimentary sequences from the western Tarim basin flanking the eastern Pamir (the Aertashi section), based on sedimentologic, provenance, and magnetostratigraphic analyses. Increased tectonic subsidence and a shift from marine to continental fluvio-deltaic deposition at 41Ma indicate that far-field deformation from the south started to affect the Tarim region. A sediment accumulation hiatus from 24.3 to 21.6Ma followed by deposition of proximal conglomerates is linked to fault propagation into the Tarim basin. From 21.6 to 15.0Ma, increasing accumulation rates of fining upward clastics is interpreted as the expression of a major dextral transtensional system linking the Kunlun to the Tian Shan ahead of the northward Pamir indentation. At 15.0Ma, the appearance of North Pamir-sourced conglomerates followed at 11Ma by Central Pamir-sourced volcanics coincides with a shift to E-W compression, clockwise vertical-axis rotations and the onset of growth strata associated with the activation of the local east vergent Qimugen thrust wedge. Together, this enables us to interpret that Pamir indentation into Tarim had started by 24.3Ma, reached the study location by 15.0Ma and had passed it by 11Ma, providing kinematic constraints on proposed tectonic models involving intracontinental subduction and delamination.
The fall into the Oligocene icehouse is marked by a steady decline in global temperature with punctuated cooling at the Eocene-Oligocene transition, both of which are well documented in the marine realm. However, the chronology and mechanisms of cooling on land remain unclear. Here, we use clumped isotope thermometry on northeastern Tibetan continental carbonates to reconstruct a detailed Paleogene surface temperature record for the Asian continental interior, and correlate this to an enhanced pollen data set. Our results show two successive dramatic (>9 degrees C) temperature drops, at 37 Ma and at 33.5 Ma. These large-magnitude decreases in continental temperatures can only be explained by a combination of both regional cooling and shifts of the rainy season to cooler months, which we interpret to reflect a decline of monsoonal intensity. Our results suggest that the response of Asian surface temperatures and monsoonal rainfall to the steady decline of atmospheric CO2 and global temperature through the late Eocene was nonlinear and occurred in two steps separated by a period of climatic instability. Our results support the onset of the Antarctic Circumpolar Current coeval to the Oligocene isotope event 1 (Oi-1) glaciation at 33.5 Ma, reshaping the distribution of surface heat worldwide; however, the origin of the 37 Ma cooling event remains less clear.
A catalog of genetic loci associated with kidney function from analyses of a million individuals
(2019)
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
Context. We present a detailed view of the pulsar wind nebula (PWN) HESS J1825-137. We aim to constrain the mechanisms dominating the particle transport within the nebula, accounting for its anomalously large size and spectral characteristics. Aims. The nebula was studied using a deep exposure from over 12 years of H.E.S.S. I operation, together with data from H.E.S.S. II that improve the low-energy sensitivity. Enhanced energy-dependent morphological and spatially resolved spectral analyses probe the very high energy (VHE, E > 0.1 TeV) gamma-ray properties of the nebula. Methods. The nebula emission is revealed to extend out to 1.5 degrees from the pulsar, similar to 1.5 times farther than previously seen, making HESS J1825-137, with an intrinsic diameter of similar to 100 pc, potentially the largest gamma-ray PWN currently known. Characterising the strongly energy-dependent morphology of the nebula enables us to constrain the particle transport mechanisms. A dependence of the nebula extent with energy of R proportional to E alpha with alpha = -0.29 +/- 0.04(stat) +/- 0.05(sys) disfavours a pure diffusion scenario for particle transport within the nebula. The total gamma-ray flux of the nebula above 1 TeV is found to be (1.12 +/- 0.03(stat) +/- 0.25(sys)) +/- 10(-11) cm(-2) s(-1), corresponding to similar to 64% of the flux of the Crab nebula. Results. HESS J1825-137 is a PWN with clearly energy-dependent morphology at VHE gamma-ray energies. This source is used as a laboratory to investigate particle transport within intermediate-age PWNe. Based on deep observations of this highly spatially extended PWN, we produce a spectral map of the region that provides insights into the spectral variation within the nebula.
Context. Pulsar wind nebulae (PWNe) represent the most prominent population of Galactic very-high-energy gamma-ray sources and are thought to be an efficient source of leptonic cosmic rays. Vela X is a nearby middle-aged PWN, which shows bright X-ray and TeV gamma-ray emission towards an elongated structure called the cocoon. Aims. Since TeV emission is likely inverse-Compton emission of electrons, predominantly from interactions with the cosmic microwave background, while X-ray emission is synchrotron radiation of the same electrons, we aim to derive the properties of the relativistic particles and of magnetic fields with minimal modelling. Methods. We used data from the Suzaku XIS to derive the spectra from three compact regions in Vela X covering distances from 0.3 to 4 pc from the pulsar along the cocoon. We obtained gamma-ray spectra of the same regions from H.E.S.S. observations and fitted a radiative model to the multi-wavelength spectra. Results. The TeV electron spectra and magnetic field strengths are consistent within the uncertainties for the three regions, with energy densities of the order 10(-12) erg cm(-3). The data indicate the presence of a cutoff in the electron spectrum at energies of similar to 100 TeV and a magnetic field strength of similar to 6 mu G. Constraints on the presence of turbulent magnetic fields are weak. Conclusions. The pressure of TeV electrons and magnetic fields in the cocoon is dynamically negligible, requiring the presence of another dominant pressure component to balance the pulsar wind at the termination shock. Sub-TeV electrons cannot completely account for the missing pressure, which may be provided either by relativistic ions or from mixing of the ejecta with the pulsar wind. The electron spectra are consistent with expectations from transport scenarios dominated either by advection via the reverse shock or by diffusion, but for the latter the role of radiative losses near the termination shock needs to be further investigated in the light of the measured cutoff energies. Constraints on turbulent magnetic fields and the shape of the electron cutoff can be improved by spectral measurements in the energy range greater than or similar to 10 keV.
Young core-collapse supernovae with dense-wind progenitors may be able to accelerate cosmic-ray hadrons beyond the knee of the cosmic-ray spectrum, and this may result in measurable gamma-ray emission. We searched for gamma-ray emission from ten super- novae observed with the High Energy Stereoscopic System (H.E.S.S.) within a year of the supernova event. Nine supernovae were observed serendipitously in the H.E.S.S. data collected between December 2003 and December 2014, with exposure times ranging from 1.4 to 53 h. In addition we observed SN 2016adj as a target of opportunity in February 2016 for 13 h. No significant gamma-ray emission has been detected for any of the objects, and upper limits on the >1 TeV gamma-ray flux of the order of similar to 10(-13) cm(-)(2)s(-1) are established, corresponding to upper limits on the luminosities in the range similar to 2 x 10(39) to similar to 1 x 10(42) erg s(-1). These values are used to place model-dependent constraints on the mass-loss rates of the progenitor stars, implying upper limits between similar to 2 x 10(-5) and similar to 2 x 10(-3) M-circle dot yr(-1) under reasonable assumptions on the particle acceleration parameters.
PKS 1830-211 is a known macrolensed quasar located at a redshift of z = 2.5. Its highenergy gamma-ray emission has been detected with the Fermi-Large Area Telescope (LAT) instrument and evidence for lensing was obtained by several authors from its high-energy data. Observations of PKS 1830-211 were taken with the High Energy Stereoscopic System (H.E.S.S.) array of Imaging Atmospheric Cherenkov Telescopes in 2014 August, following a flare alert by the Fermi-LAT Collaboration. The H.E.S.S observations were aimed at detecting a gamma-ray flare delayed by 20-27 d from the alert flare, as expected from observations at other wavelengths. More than 12 h of good-quality data were taken with an analysis threshold of similar to 67 GeV. The significance of a potential signal is computed as a function of the date and the average significance over the whole period. Data are compared to simultaneous observations by Fermi-LAT. No photon excess or significant signal is detected. An upper limit on PKS 1830-211 flux above 67 GeV is computed and compared to the extrapolation of the Fermi-LAT flare spectrum.
Technical report
(2019)
Design and Implementation of service-oriented architectures imposes a huge number of research questions from the fields of software engineering, system analysis and modeling, adaptability, and application integration. Component orientation and web services are two approaches for design and realization of complex web-based system. Both approaches allow for dynamic application adaptation as well as integration of enterprise application.
Commonly used technologies, such as J2EE and .NET, form de facto standards for the realization of complex distributed systems. Evolution of component systems has lead to web services and service-based architectures. This has been manifested in a multitude of industry standards and initiatives such as XML, WSDL UDDI, SOAP, etc. All these achievements lead to a new and promising paradigm in IT systems engineering which proposes to design complex software solutions as collaboration of contractually defined software services.
Service-Oriented Systems Engineering represents a symbiosis of best practices in object-orientation, component-based development, distributed computing, and business process management. It provides integration of business and IT concerns.
The annual Ph.D. Retreat of the Research School provides each member the opportunity to present his/her current state of their research and to give an outline of a prospective Ph.D. thesis. Due to the interdisciplinary structure of the research school, this technical report covers a wide range of topics. These include but are not limited to: Human Computer Interaction and Computer Vision as Service; Service-oriented Geovisualization Systems; Algorithm Engineering for Service-oriented Systems; Modeling and Verification of Self-adaptive Service-oriented Systems; Tools and Methods for Software Engineering in Service-oriented Systems; Security Engineering of Service-based IT Systems; Service-oriented Information Systems; Evolutionary Transition of Enterprise Applications to Service Orientation; Operating System Abstractions for Service-oriented Computing; and Services Specification, Composition, and Enactment.
The establishment and evolution of the Asian monsoons and arid interior have been linked to uplift of the Tibetan Plateau, retreat of the inland proto-Paratethys Sea and global cooling during the Cenozoic. However, the respective role of these driving mechanisms remains poorly constrained. This is partly due to a lack of continental records covering the key Eocene epoch marked by the onset of Tibetan Plateau uplift, proto-Paratethys Sea incursions and long-term global cooling. In this study, we reconstruct paleoenvironments in the Xining Basin, NE Tibet, to show a long-term drying of the Asian continental interior from the early Eocene to the Oligocene. Superimposed on this trend are three alternations between arid mudflat and wetter saline lake intervals, which are interpreted to reflect atmospheric moisture fluctuations in the basin. We date these fluctuations using magnetostratigraphy and the radiometric age of an intercalated tuff layer. The first saline lake interval is tentatively constrained to the late Paleocene-early Eocene. The other two are firmly dated between similar to 46 Ma (top magnetochron C21n) and similar to 41 Ma (base C18r) and between similar to 40 Ma (base C18n) and similar to 37 Ma (top C17n). Remarkably, these phases correlate in time with highstands of the proto-Paratethys Sea. This strongly suggests that these sea incursions enhanced westerly moisture supply as far inland as the Xining Basin. We conclude that the proto-Paratethys Sea constituted a key driver of Asian climate and should be considered in model and proxy interpretations. (C) 2019 Elsevier B.V. All rights reserved.
Convergence between the Indian and Asian plates has reshaped large parts of Asia, changing regional climate and biodiversity, yet geodynamic models fundamentally diverge on how convergence was accommodated since the India-Asia collision. Here we report palaeomagnetic data from the Burma Terrane, which is at the eastern edge of the collision zone and is famous for its Cretaceous amber biota, to better determine the evolution of the India-Asia collision. The Burma Terrane was part of a Trans-Tethyan island arc and stood at a near-equatorial southern latitude at similar to 95 Ma, suggesting island endemism for the Burmese amber biota. The Burma Terrane underwent significant clockwise rotation between similar to 80 and 50 Ma, causing its subduction margin to become hyper-oblique. Subsequently, it was translated northward on the Indian Plate by an exceptional distance of at least 2,000 km along a dextral strike-slip fault system in the east. Our reconstructions are only compatible with geodynamic models involving an initial collision of India with a near-equatorial Trans-Tethyan subduction system at similar to 60 Ma, followed by a later collision with the Asian margin.
We combine ultrafast X-ray diffraction (UXRD) and time-resolved Magneto-Optical Kerr Effect (MOKE) measurements to monitor the strain pulses in laser-excited TbFe2/Nb heterostructures. Spatial separation of the Nb detection layer from the laser excitation region allows for a background-free characterization of the laser-generated strain pulses. We clearly observe symmetric bipolar strain pulses if the excited TbFe2 surface terminates the sample and a decomposition of the strain wavepacket into an asymmetric bipolar and a unipolar pulse, if a SiO2 glass capping layer covers the excited TbFe2 layer. The inverse magnetostriction of the temporally separated unipolar strain pulses in this sample leads to a MOKE signal that linearly depends on the strain pulse amplitude measured through UXRD. Linear chain model simulations accurately predict the timing and shape of UXRD and MOKE signals that are caused by the strain reflections from multiple interfaces in the heterostructure.
Objective: The purpose of this systematic review and meta-analysis was to examine the effects of exercise on depression and anxiety in people living with HIV (PLWH), and to evaluate, through subgroup analysis, the effects of exercise type, frequency, supervision by exercise professionals, study quality, and control group conditions on these outcomes. Method: A literature search was conducted through four electronic databases from inception to February 2019. Considered for inclusion were randomized controlled trials (RCTs) investigating exercise interventions and depression or anxiety as outcomes in people living with HIV (>= 18 years of age). Ten studies were included (n = 479 participants, 49.67% females at baseline), and the standardized mean difference (SMD) and heterogeneity were calculated using random-effect models. An additional pre-post meta-analysis was also conducted. Results: A large effect in favor of exercise when compared to controls was found for depression (SMD = -0.84, 95%CI = [-1.57, -0.11], p = 0.02) and anxiety (SMD = -1.23, 95%CI = [-2.42, 0.04], p = -0.04). Subgroup analyses for depression revealed large effects on depression for aerobic exercise only (SMD = -0.96, 95%CI = [-1.63, -0.30], p = 0.004), a frequency of >= 3 exercise sessions per week (SMD = -1.39, 95%CI = [-2.24, -0.54], p < 0.001), professionally supervised exercise (SMD = -1.40, 95%CI = [-2.46, -0.17], p = 0.03]), and high-quality studies (SMD = -1.31, 95%CI = [-2.46, -0.17], p = 0.02). Conclusion: Exercise seems to decrease depressive symptoms and anxiety in PLWH, but other larger and high-quality studies are needed to verify these effects.
We investigate the ultrafast magnetization dynamics of FePt in the L1(0) phase after an optical heating pulse, as used in heat-assisted magnetic recording. We compare continuous and nano-granular thin films and emphasize the impact of the finite size on the remagnetization dynamics. The remagnetization speeds up significantly with increasing external magnetic field only for the continuous film, where domain-wall motion governs the dynamics. The ultrafast remagnetization dynamics in the continuous film are only dominated by heat transport in the regime of high magnetic fields, whereas the timescale required for cooling is prevalent in the granular film for all magnetic field strengths. These findings highlight the necessary conditions for studying the intrinsic heat transport properties in magnetic materials.
Poverty and social exclusion are closely related to an increased risk for the deterioration of mental health. In 2018 approximately 19% of the German population were threatened by poverty and the associated social ostracization. Migrant groups in particular often show an increased risk for poverty and are often exposed to multiple socioeconomic stress factors depending on the context of migration, pre-migration and post-migration social factors. Numerous studies have shown that societal exclusion, precarious living conditions and the residential environment negatively affect mental health beyond the effects of pre-migration risk factors. This article provides a review and discussion on the relationship between mental health, poverty and related constructs, such as social cohesion, social capital and social exclusion in general as well as in specific risk groups, such as migrant and refugee populations.
Der demografische Wandel wird nicht nur mit einer rasanten Zunahme der Hochaltrigen einhergehen [1], was für die gerontopsychiatrische Versorgung aufgrund der altersassoziierten Inzidenzraten in erster Linie eine Zunahme an Demenzerkrankungen und Patienten mit Multimorbidität und Gebrechlichkeit bedeutet [2], sondern auch mit einer Zunahme jüngerer alter Menschen vom 65. bis 75. Lebensjahr, was für die Gerontopsychiatrie eine Zunahme der Patienten mit Abhängigkeitserkrankungen, Erkrankungen aus dem schizophrenen Formenkreis und affektiven Erkrankungen bedeutet. Soziale Faktoren werden hier mehr und mehr eine zentrale Rolle spielen, da neben der Qualität der medizinischen Versorgung insbesondere die individuelle soziale Situation der Patienten mit einer erhöhten Morbidität und Mortalität einhergehen wird [3].
Wenn in der Medizin vom demografischen Wandel gesprochen wird [1], wird zumeist von einer rasanten Zunahme der Hochaltrigen gesprochen, bei denen aufgrund der differenziellen altersassoziierten Inzidenzraten in erster Linie eine Zunahme an Demenzerkrankungen, kardiovaskulären Erkrankungen, Krebserkrankungen und allgemeiner Multimorbidität und Gebrechlichkeit zu erwarten ist [2]. Dies ist unstrittig richtig, aber nur ein Teil der Folgen des demografischen Wandels für die psychiatrische Versorgung. Diese muss weiterhin die gesamte adulte Lebensspanne im Blick haben, da sonst Versorgungsengpässe bei ohnehin vulnerablen Patienten verstärkt werden, mit Folgen für die Morbidität und Mortalität auf Bevölkerungsebene [3].
Experimental studies have reported on the anti-inflammatory properties of polyphenols. However, results from epidemiological investigations have been inconsistent and especially studies using biomarkers for assessment of polyphenol intake have been scant. We aimed to characterise the association between plasma concentrations of thirty-five polyphenol compounds and low-grade systemic inflammation state as measured by high-sensitivity C-reactive protein (hsCRP). A cross-sectional data analysis was performed based on 315 participants in the European Prospective Investigation into Cancer and Nutrition cohort with available measurements of plasma polyphenols and hsCRP. In logistic regression analysis, the OR and 95 % CI of elevated serum hsCRP (>3 mg/l) were calculated within quartiles and per standard deviation higher level of plasma polyphenol concentrations. In a multivariable-adjusted model, the sum of plasma concentrations of all polyphenols measured (per standard deviation) was associated with 29 (95 % CI 50, 1) % lower odds of elevated hsCRP. In the class of flavonoids, daidzein was inversely associated with elevated hsCRP (OR 0 center dot 66, 95 % CI 0 center dot 46, 0 center dot 96). Among phenolic acids, statistically significant associations were observed for 3,5-dihydroxyphenylpropionic acid (OR 0 center dot 58, 95 % CI 0 center dot 39, 0 center dot 86), 3,4-dihydroxyphenylpropionic acid (OR 0 center dot 63, 95 % CI 0 center dot 46, 0 center dot 87), ferulic acid (OR 0 center dot 65, 95 % CI 0 center dot 44, 0 center dot 96) and caffeic acid (OR 0 center dot 69, 95 % CI 0 center dot 51, 0 center dot 93). The odds of elevated hsCRP were significantly reduced for hydroxytyrosol (OR 0 center dot 67, 95 % CI 0 center dot 48, 0 center dot 93). The present study showed that polyphenol biomarkers are associated with lower odds of elevated hsCRP. Whether diet rich in bioactive polyphenol compounds could be an effective strategy to prevent or modulate deleterious health effects of inflammation should be addressed by further well-powered longitudinal studies.
The flat spectrum radio quasar 3C 279 is known to exhibit pronounced variability in the high-energy (100MeV < E < 100 GeV) gamma-ray band, which is continuously monitored with Fermi-LAT. During two periods of high activity in April 2014 and June 2015 target-of-opportunity observations were undertaken with the High Energy Stereoscopic System (H.E.S.S.) in the very-high-energy (VHE, E > 100 GeV) gamma-ray domain. While the observation in 2014 provides an upper limit, the observation in 2015 results in a signal with 8 : 7 sigma significance above an energy threshold of 66 GeV. No VHE variability was detected during the 2015 observations. The VHE photon spectrum is soft and described by a power-law index of 4.2 +/- 0.3. The H.E.S.S. data along with a detailed and contemporaneous multiwavelength data set provide constraints on the physical parameters of the emission region. The minimum distance of the emission region from the central black hole was estimated using two plausible geometries of the broad-line region and three potential intrinsic spectra. The emission region is confidently placed at r greater than or similar to 1 : 7 X 1017 cm from the black hole, that is beyond the assumed distance of the broad-line region. Time-dependent leptonic and lepto-hadronic one-zone models were used to describe the evolution of the 2015 flare. Neither model can fully reproduce the observations, despite testing various parameter sets. Furthermore, the H.E.S.S. data were used to derive constraints on Lorentz invariance violation given the large redshift of 3C 279.
Paleogeographic reconstructions of terranes can greatly benefit from the provenance analysis of sediments. A series of Cenozoic basins provide key sedimentary archives for investigating the growth of the Tibetan Plateau, yet the provenance of the sediments in these basins has never been constrained robustly. Here we report sedimentary petrological and detrital zircon geochronological data from the Paleocene-Eocene Nangqian-Xialaxiu and Gongjue basins. Sandstone detrital modes and zircon morphology suggest that the samples collected in these two basins were sourced from recycled orogen. Detrital zircon geochronology indicates that sediments in the Nangqian-Xialaxiu Basin are characterized by two distinct age populations at 220-280 Ma and 405-445 Ma. In contrast, three predominant age populations of 207-256 Ma, 423-445 Ma, and 1851-1868 Ma, and two subordinate age populations of similar to 50 Ma and similar to 2500 Ma, are recognized in the Gongjue Basin. Comparison with detrital zircon ages from the surrounding terranes suggests that sediments in the Nangqian-Xialaxiu Basin come from the neighboring thrust belts, whereas sediments from the Gongjue Basin are predominantly derived from the distant Songpan-Ganzi Terrane with minor contribution from the surrounding areas. A three-stage Cenozoic evolution of the eastern Tibetan Plateau is proposed. During the Paleocene, the Nangqian-Xialaxiu Basin appeared as a set of small intermontane sub-basins and received plentiful sediments from the neighboring mountain belts; during the Eocene, the Gongjue Basin kept a relatively low altitude and was a depression at the edge of a proto-Plateau; since the Oligocene, the Tibetan Plateau further uplifted and the marginal Gongjue Basin was involved in the Tibetan interior orogeny, indicating the eastward propagation of the Tibetan Plateau.
An understanding of the depositional environment and paleogeography of the Siwalik foreland basin are crucial in interpreting the basin configuration, sediment transport pathways and its evolutionary history. This study examines the sedimentology of the Siwalik succession of the Kameng River valley, Arunachal Himalaya, northeastern India. The facies characteristics of the fine-grained, well-sorted sediments of the Dafla Formation and its complex, polymodal paleocurrent pattern in this section, reveals deposition in a variety of open marine to deltaic environment. The overlying Subansiri Formation, characterized by coarse-grained, thick, multistoried sandstone, and showing more consistent SW-ward paleocurrent, indicate deposition from a large, axial braided river system. The proposed redefinition of the boundary between the Lower Siwalik Dafia and the Middle Siwalik Subansiri formations implies their transition at around 7.5 Ma, instead of 10.5 Ma, suggested earlier. The revised age of the transition is consistent with the age of arrival of the Transhimalayan sediments at 7 Ma and also denotes the time of marine to fluvial transition in this area. Presence of marine sediments in the Kameng section, with similar records further west, indicates the existence of an extensive seaway in the eastern Himalaya during the lower Siwalik time. The extant paleodrainage reconstructions have been recast on the basis of new data on the sedimentology and paleocurrent from this section. It is inferred that the changing sea level, uplifting Shillong Plateau and drainage evolution in the eastern Himalayan foreland during the middle Miocene time controlled the marine to fluvial transition in the basin.
The blazar Mrk 501 (z = 0.034) was observed at very-high-energy (VHE, E greater than or similar to 100 GeV) gamma-ray wavelengths during a bright flare on the night of 2014 June 23-24 (MJD 56832) with the H.E.S.S. phase-II array of Cherenkov telescopes. Data taken that night by H.E.S.S. at large zenith angle reveal an exceptional number of gamma-ray photons at multi-TeV energies, with rapid flux variability and an energy coverage extending significantly up to 20 TeV. This data set is used to constrain Lorentz invariance violation (LIV) using two independent channels: a temporal approach considers the possibility of an energy dependence in the arrival time of gamma-rays, whereas a spectral approach considers the possibility of modifications to the interaction of VHE gamma-rays with extragalactic background light (EBL) photons. The non-detection of energy-dependent time delays and the non-observation of deviations between the measured spectrum and that of a supposed power-law intrinsic spectrum with standard EBL attenuation are used independently to derive strong constraints on the energy scale of LIV (E-QG) in the subluminal scenario for linear and quadratic perturbations in the dispersion relation of photons. For the case of linear perturbations, the 95% confidence level limits obtained are E-QG,E-1 > 3.6 x 10(17) GeV using the temporal approach and E-QG,E-1 > 2.6 x 10(19) GeV using the spectral approach. For the case of quadratic perturbations, the limits obtained are E-QG,E-2 > 8.5 x 10(10) GeV using the temporal approach and E-QG,E-2 > 7.8 x 10(11) GeV using the spectral approach.
Gamma-ray bursts (GRBs) are brief flashes of gamma-rays and are considered to be the most energetic explosive phenomena in the Universe(1). The emission from GRBs comprises a short (typically tens of seconds) and bright prompt emission, followed by a much longer afterglow phase. During the afterglow phase, the shocked outflow-produced by the interaction between the ejected matter and the circumburst medium-slows down, and a gradual decrease in brightness is observed(2). GRBs typically emit most of their energy via.-rays with energies in the kiloelectronvolt-to-megaelectronvolt range, but a few photons with energies of tens of gigaelectronvolts have been detected by space-based instruments(3). However, the origins of such high-energy (above one gigaelectronvolt) photons and the presence of very-high-energy (more than 100 gigaelectronvolts) emission have remained elusive(4). Here we report observations of very-high-energy emission in the bright GRB 180720B deep in the GRB afterglow-ten hours after the end of the prompt emission phase, when the X-ray flux had already decayed by four orders of magnitude. Two possible explanations exist for the observed radiation: inverse Compton emission and synchrotron emission of ultrarelativistic electrons. Our observations show that the energy fluxes in the X-ray and gamma-ray range and their photon indices remain comparable to each other throughout the afterglow. This discovery places distinct constraints on the GRB environment for both emission mechanisms, with the inverse Compton explanation alleviating the particle energy requirements for the emission observed at late times. The late timing of this detection has consequences for the future observations of GRBs at the highest energies.
Binaries play an important role in observational and theoretical astrophysics. Since the mass and the chemical composition are key ingredients for stellar evolution, high-resolution spectroscopy is an important and necessary tool to derive those parameters to high confidence in binaries. This involves carefully measured orbital motion by the determination of radial velocity (RV) shifts and sophisticated techniques to derive the abundances of elements within the stellar atmosphere.
A technique superior to conventional cross-correlation methods to determine RV shifts in known as spectral disentangling. Hence, a major task of this thesis was the design of a sophisticated software package for this approach. In order to investigate secondary effects, such as flux and line-profile variations, imprinting changes on the spectrum the behavior of spectral disentangling on such variability is a key to understand the derived values, to improve them, and to get information about the variability itself. Therefore, the spectral disentangling code presented in this thesis and available to the community combines multiple advantages: separation of the spectra for detailed chemical analysis, derivation of orbital elements, derivation of individual RVs in order to investigate distorted systems (either by third body interaction or relativistic effects), the suppression of telluric contaminations, the derivation of variability, and the possibility to apply the technique to eclipsing binaries (important for orbital inclination) or in general to systems that undergo flux-variations.
This code in combination with the spectral synthesis codes MOOG and SME was used in order to derive the carbon 12C/13C isotope ratio (CIR) of the benchmark binary Capella. The observational result will be set into context with theoretical evolution by the use of MESA models and resolves the discrepancy of theory and observations existing since the first measurement of Capella's CIR in 1976.
The spectral disentangling code has been made available to the community and its applicability to completely different behaving systems, Wolf-Rayet stars, have also been investigated and resulted in a published article.
Additionally, since this technique relies strongly on data quality, continues development of scientific instruments to achieve best observational data is of great importance in observational astrophysics. That is the reason why there has also been effort in astronomical instrumentation during the work on this thesis.
Carbonate rocks, widely used for paleomagnetically quantifying the drift history of the Gondwana derived continental blocks of the Tibetan Plateau and evolution of the Paleo/Meso/Neo-Tethys Oceans, are prone to pervasive remagnetization. Identifying remagnetization is difficult because it is commonly undetectable through the classic paleomagnetic field tests. Here we apply comprehensive paleomagnetic, rock magnetic, and petrographic studies to upper Triassic limestones in the eastern Qiangtang block. Our results reveal that detrital/biogenic magnetite, which may carry the primary natural remanent magnetization (NRM), is rarely preserved in these rocks. In contrast, authigenic magnetite and hematite pseudomorphs after pyrite, and monoclinic pyrrhotite record three episodes of remagnetization. The earliest remagnetization was induced by oxidation of early diagenetic pyrite to magnetite, probably related to the collision between the northeastern Tibetan Plateau and the Qiangtang block after closure of the Paleo-Tethys Ocean in the Late Triassic. The second remagnetization, residing in hematite and minor goethite, which is the further subsurface oxidation product of pyrite/magnetite, is possibly related to the development of the localized Cenozoic basins soon after India-Asia collision in the Paleocene. The youngest remagnetization is a combination of thermoviscous and chemical remanent magnetization carried by authigenic magnetite and pyrrhotite, respectively. Our analyses suggest that a high supply of organic carbon during carbonate deposition, prevailing sulfate reducing conditions during early diagenesis, and widespread orogenic fluid migration related to crustal shortening during later diagenesis, have altered the primary remanence of the shallow-water Tethyan carbonate rocks of the Tibetan Plateau. We emphasize that all paleomagnetic results from these rocks must be carefully examined for remagnetization before being used for paleogeographic reconstructions. Future paleomagnetic investigations of the carbonate rocks in orogenic belts should be accompanied by thorough rock magnetic and petrographic studies to determine the origin of the NRM. (C) 2019 Elsevier B.V. All rights reserved.
Wastewater treatment is crucial to environmental hygiene in urban environments. However, wastewater treatment plants (WWTPs) collect chemicals, organic matter, and microorganisms including pathogens and multi-resistant bacteria from various sources which may be potentially released into the environment via WWTP effluent. To better understand microbial dynamics in WWTPs, we characterized and compared the bacterial community of the inflow and effluent of a WWTP in Berlin, Germany using full-length 16S rRNA gene sequences, which allowed for species level determination in many cases and generally resolved bacterial taxa. Significantly distinct bacterial communities were identified in the wastewater inflow and effluent samples. Dominant operational taxonomic units (OTUs) varied both temporally and spatially. Disease associated bacterial groups were efficiently reduced in their relative abundance from the effluent by the WWTP treatment process, except for Legionella and Leptospira species which demonstrated an increase in relative proportion from inflow to effluent. This indicates that WWTPs, while effective against enteric bacteria, may enrich and release other potentially pathogenic bacteria into the environment. The taxonomic resolution of full-length 16S rRNA genes allows for improved characterization of potential pathogenic taxa and other harmful bacteria which is required to reliably assess health risk.
Water is essential to life and thus, an essential resource. However, freshwater resources are limited and their maintenance is crucial. Pollution with chemicals and pathogens through urbanization and a growing population impair the quality of freshwater. Furthermore, water can serve as vector for the transmission of pathogens resulting in water-borne illness.
The Interdisciplinary Research Group III – "Water" of the Leibniz alliance project INFECTIONS‘21 investigated water as a hub for pathogens focusing on Clostridioides difficile and avian influenza A viruses that may be shed into the water. Another aim of this study was to characterize the bacterial communities in a wastewater treatment plant (WWTP) of the capital Berlin, Germany to further assess potential health risks associated with wastewater management practices.
Bacterial communities of WWTP inflow and effluent differed significantly. The proportion of fecal/enteric bacteria was relatively low and OTUs related to potential enteric pathogens were largely removed from inflow to effluent. However, a health risk might exist as an increased relative abundance of potential pathogenic Legionella spp. such as L. lytica was observed. Three Clostridioides difficile isolates from wastewater inflow and an urban bathing lake in Berlin (‗Weisser See‘) were obtained and sequenced. The two isolates from the wastewater did not carry toxin genes, whereas the isolate from the lake was positive for the toxin genes. All three isolates were closely related to human strains. This indicates a potential, but rather sporadic health risk. Avian influenza A viruses were detected in 38.8% of sediment samples by PCR, but virus isolation failed. An experiment with inoculated freshwater and sediment samples showed that virus isolation from sediment requires relatively high virus concentrations and worked much better in Madin-Darby Canine Kidney (MDCK) cell cultures than in embryonated chicken eggs, but low titre of influenza contamination in freshwater samples was sufficient to recover virus.
In conclusion, this work revealed potential health risks coming from bacterial groups with pathogenic potential such as Legionella spp. whose relative abundance is higher in the released effluent than in the inflow of the investigated WWTP. It further indicates that water bodies such as wastewater and lake sediments can serve as reservoir and vector, even for non-typical water-borne or water-transmitted pathogens such as C. difficile.
Objectives
The aims of this study were to investigate the effects of a six-week in-season period of soccer training and games (congested period) on plasma volume variations (PV), hematological parameters, and physical fitness in elite players. In addition, we analyzed relationships between training load, hematological parameters and players’ physical fitness.
Methods
Eighteen elite players were evaluated before (T1) and after (T2) a six-week in-season period interspersed with 10 soccer matches. At T1 and T2, players performed the Yo-Yo intermittent recovery test level 1 (YYIR1), the repeated shuttle sprint ability test (RSSA), the countermovement jump test (CMJ), and the squat jump test (SJ). In addition, PV and hematological parameters (erythrocytes [M/mm3], hematocrit [%], hemoglobin [g/dl], mean corpuscular volume [fl], mean corpuscular hemoglobin content [pg], and mean hemoglobin concentration [%]) were assessed. Daily ratings of perceived exertion (RPE) were monitored in order to quantify the internal training load.
Results
From T1 to T2, significant performance declines were found for the YYIR1 (p<0.001, effect size [ES] = 0.5), RSSA (p<0.01, ES = 0.6) and SJ tests (p< 0.046, ES = 0.7). However, no significant changes were found for the CMJ (p = 0.86, ES = 0.1). Post-exercise, RSSA blood lactate (p<0.012, ES = 0.2) and PV (p<0.01, ES = 0.7) increased significantly from T1 to T2. A significant decrease was found from T1 to T2 for the erythrocyte value (p<0.002, ES = 0.5) and the hemoglobin concentration (p<0.018, ES = 0.8). The hematocrit percentage rate was also significantly lower (p<0.001, ES = 0.6) at T2. The mean corpuscular volume, mean corpuscular hemoglobin content and the mean hemoglobin content values were not statistically different from T1 to T2. No significant relationships were detected between training load parameters and percentage changes of hematological parameters. However, a significant relationship was observed between training load and changes in RSSA performance (r = -0.60; p<0.003).
Conclusions
An intensive period of “congested match play” over 6 weeks significantly compromised players’ physical fitness. These changes were not related to hematological parameters, even though significant alterations were detected for selected measures.
Context. The TESS satellite was launched in 2018 to perform high-precision photometry from space over almost the whole sky in a search for exoplanets orbiting bright stars. This instrument has opened new opportunities to study variable hot subdwarfs, white dwarfs, and related compact objects. Targets of interest include white dwarf and hot subdwarf pulsators, both carrying high potential for asteroseismology. Aims. We present the discovery and detailed asteroseismic analysis of a new g-mode hot B subdwarf (sdB) pulsator, EC 21494-7018 (TIC 278659026), monitored in TESS first sector using 120-s cadence. Methods. The TESS light curve was analyzed with standard prewhitening techniques, followed by forward modeling using our latest generation of sdB models developed for asteroseismic investigations. By simultaneously best-matching all the observed frequencies with those computed from models, we identified the pulsation modes detected and, more importantly, we determined the global parameters and structural configuration of the star. Results. The light curve analysis reveals that EC 21494-7018 is a sdB pulsator counting up to 20 frequencies associated with independent g-modes. The seismic analysis singles out an optimal model solution in full agreement with independent measurements provided by spectroscopy (atmospheric parameters derived from model atmospheres) and astrometry (distance evaluated from Gaia DR2 trigonometric parallax). Several key parameters of the star are derived. Its mass (0.391 +/- 0.009x2006;M-circle dot) is significantly lower than the typical mass of sdB stars and suggests that its progenitor has not undergone the He-core flash; therefore this progenitor could originate from a massive (greater than or similar to 2;M-circle dot) red giant, which is an alternative channel for the formation of sdBs. Other derived parameters include the H-rich envelope mass (0.0037 +/- 0.0010;M-circle dot), radius (0.1694 +/- 0.0081;R-circle dot), and luminosity (8.2 +/- 1.1;L-circle dot). The optimal model fit has a double-layered He+H composition profile, which we interpret as an incomplete but ongoing process of gravitational settling of helium at the bottom of a thick H-rich envelope. Moreover, the derived properties of the core indicate that EC 21494-7018 has burnt similar to 43% (in mass) of its central helium and possesses a relatively large mixed core (M-core;=;0.198 +/- 0.010;M-circle dot), in line with trends already uncovered from other g-mode sdB pulsators analyzed with asteroseismology. Finally, we obtain for the first time an estimate of the amount of oxygen (in mass; X(O)(core) = 0.16(-0.05)(+0.13)X(O)core=0.16-0.05+0.13$ X(mathrm{O})_{mathrm{core}}=0.16_{-0.05}<^>{+0.13} $) produced at this stage of evolution by an helium-burning core. This result, along with the core-size estimate, is an interesting constraint that may help to narrow down the still uncertain C-12(alpha,;gamma)O-16 nuclear reaction rate.
We report the discovery of three stars that, along with the prototype LP 40-365, form a distinct class of chemically peculiar runaway stars that are the survivors of thermonuclear explosions. Spectroscopy of the four confirmed LP 40-365 stars finds ONe-dominated atmospheres enriched with remarkably similar amounts of nuclear ashes of partial O- and Si-burning. Kinematic evidence is consistent with ejection from a binary supernova progenitor; at least two stars have rest-frame velocities indicating they are unbound to the Galaxy. With masses and radii ranging between 0.20 and 0.28M(circle dot) and between 0.16 and 0.60 R-circle dot, respectively, we speculate these inflated white dwarfs are the partly burnt remnants of either peculiar Type Iax or electron-capture supernovae. Adopting supernova rates from the literature, we estimate that similar to 20 LP 40-365 stars brighter than 19 mag should be detectable within 2 kpc from the Sun at the end of the Gaia mission. We suggest that as they cool, these stars will evolve in their spectroscopic appearance, and eventually become peculiar O-rich white dwarfs. Finally, we stress that the discovery of new LP 40-365 stars will be useful to further constrain their evolution, supplying key boundary conditions to the modelling of explosion mechanisms, supernova rates, and nucleosynthetic yields of peculiar thermonuclear explosions.
Objectives
The aims of this study were to investigate the effects of a six-week in-season period of soccer training and games (congested period) on plasma volume variations (PV), hematological parameters, and physical fitness in elite players. In addition, we analyzed relationships between training load, hematological parameters and players’ physical fitness.
Methods
Eighteen elite players were evaluated before (T1) and after (T2) a six-week in-season period interspersed with 10 soccer matches. At T1 and T2, players performed the Yo-Yo intermittent recovery test level 1 (YYIR1), the repeated shuttle sprint ability test (RSSA), the countermovement jump test (CMJ), and the squat jump test (SJ). In addition, PV and hematological parameters (erythrocytes [M/mm3], hematocrit [%], hemoglobin [g/dl], mean corpuscular volume [fl], mean corpuscular hemoglobin content [pg], and mean hemoglobin concentration [%]) were assessed. Daily ratings of perceived exertion (RPE) were monitored in order to quantify the internal training load.
Results
From T1 to T2, significant performance declines were found for the YYIR1 (p<0.001, effect size [ES] = 0.5), RSSA (p<0.01, ES = 0.6) and SJ tests (p< 0.046, ES = 0.7). However, no significant changes were found for the CMJ (p = 0.86, ES = 0.1). Post-exercise, RSSA blood lactate (p<0.012, ES = 0.2) and PV (p<0.01, ES = 0.7) increased significantly from T1 to T2. A significant decrease was found from T1 to T2 for the erythrocyte value (p<0.002, ES = 0.5) and the hemoglobin concentration (p<0.018, ES = 0.8). The hematocrit percentage rate was also significantly lower (p<0.001, ES = 0.6) at T2. The mean corpuscular volume, mean corpuscular hemoglobin content and the mean hemoglobin content values were not statistically different from T1 to T2. No significant relationships were detected between training load parameters and percentage changes of hematological parameters. However, a significant relationship was observed between training load and changes in RSSA performance (r = -0.60; p<0.003).
Conclusions
An intensive period of “congested match play” over 6 weeks significantly compromised players’ physical fitness. These changes were not related to hematological parameters, even though significant alterations were detected for selected measures.
Fungi are an important component of microbial communities and are well known for their ability to decompose refractory, highly polymeric organic matter. In soils and aquatic systems, fungi play an important role in carbon processing, however, their diversity, community structure and function as well as ecological role, particularly in groundwater, are poorly studied. The aim of this study was to examine the fungal community composition, diversity and function in groundwater from 16 boreholes located in the vicinity of two lakes in NE Germany that are characterized by contrasting trophic status. The analysis of 28S rRNA gene sequences amplified from the groundwater revealed high fungal diversity arid clear differences in community structure between the aquifers. Most sequences were assigned to Ascomycota and Basidiomycota, but members of Chytridiomycota, Cryptomycota, Zygomycota, Blastocladiomycota, Glomeromycota and Neocallimastigomycota were also detected. In addition, 27 species of fungi were successfully isolated from the groundwater samples and tested for their ability to decompose complex organic polymers - the predominant carbon source in the groundwater. Most isolates showed positive activities for at least one of the tested polymer types, with three strains, belonging to the genera Gibberella, Isaria and Cadophora, able to decompose all tested substrates. Our results highlight the high diversity of fungi in groundwater, and point to their important ecological role in breaking down highly polymeric organic matter in these isolated microbial habitats. (C) 2019 Elsevier Ltd and British Mycological Society. All rights reserved.
We present new conditions for semigroups of positive operators to converge strongly as time tends to infinity. Our proofs are based on a novel approach combining the well-known splitting theorem by Jacobs, de Leeuw, and Glicksberg with a purely algebraic result about positive group representations. Thus, we obtain convergence theorems not only for one-parameter semigroups but also for a much larger class of semigroup representations. Our results allow for a unified treatment of various theorems from the literature that, under technical assumptions, a bounded positive C-0-semigroup containing or dominating a kernel operator converges strongly as t ->infinity. We gain new insights into the structure theoretical background of those theorems and generalize them in several respects; especially we drop any kind of continuity or regularity assumption with respect to the time parameter.
Hypervelocity stars are rare objects, mostly main-sequence (MS) B stars, traveling so fast that they will eventually escape from the Milky Way. Recently, it has been shown that the popular Hills mechanism, in which a binary system is disrupted via a close encounter with the supermassive black hole at the Galactic center, may not be their only ejection mechanism. The analyses of Gaia data ruled out a Galactic center origin for some of them, and instead indicated that they are extreme disk runaway stars ejected at velocities exceeding the predicted limits of classical scenarios (dynamical ejection from star clusters or binary supernova ejection). We present the discovery of a new extreme disk runaway star, PG 1610+062, which is a slowly pulsating B star bright enough to be studied in detail. A quantitative analysis of spectra taken with ESI at the Keck Observatory revealed that PG 1610+062 is a late B-type MS star of 4–5 M⊙ with low projected rotational velocity. Abundances (C, N, O, Ne, Mg, Al, Si, S, Ar, and Fe) were derived differentially with respect to the normal B star HD 137366 and indicate that PG 1610+062 is somewhat metal rich. A kinematic analysis, based on our spectrophotometric distance (17.3 kpc) and on proper motions from Gaia’s second data release, shows that PG 1610+062 was probably ejected from the Carina-Sagittarius spiral arm at a velocity of 550 ± 40 km s−1, which is beyond the classical limits. Accordingly, the star is in the top five of the most extreme MS disk runaway stars and is only the second among the five for which the chemical composition is known.
Eclipsing post-common-envelope binaries are highly important for resolving the poorly understood, very short-lived common-envelope phase of stellar evolution. Most hot subdwarfs (sdO/Bs) are the bare helium-burning cores of red giants that have lost almost all of their hydrogen envelope. This mass loss is often triggered by common-envelope interactions with close stellar or even substellar companions. Cool companions to hot subdwarf stars such as late-type stars and brown dwarfs are detectable from characteristic light-curve variations - reflection effects and often eclipses. In the recently published catalog of eclipsing binaries in the Galactic Bulge and in the Asteroid Terrestrial-impact Last Alert System (ATLAS) survey, we discovered 125 new eclipsing systems showing a reflection effect seen by visual inspection of the light curves and using a machine-learning algorithm, in addition to the 36 systems previously discovered by the Optical Gravitational Lesing Experiment (OGLE) team. The Eclipsing Reflection Effect Binaries from Optical Surveys (EREBOS) project aims at analyzing all newly discovered eclipsing binaries of the HW Vir type (hot subdwarf + close, cool companion) based on a spectroscopic and photometric follow up to derive the mass distribution of the companions, constrain the fraction of substellar companions, and determine the minimum mass needed to strip off the red-giant envelope. To constrain the nature of the primary we derived the absolute magnitude and the reduced proper motion of all our targets with the help of the parallaxes and proper motions measured by the Gaia mission and compared those to the Gaia white-dwarf candidate catalog. It was possible to derive the nature of a subset of our targets, for which observed spectra are available, by measuring the atmospheric parameter of the primary, confirming that less than 10% of our systems are not sdO/Bs with cool companions but are white dwarfs or central stars of planetary nebula. This large sample of eclipsing hot subdwarfs with cool companions allowed us to derive a significant period distribution for hot subdwarfs with cool companions for the first time showing that the period distribution is much broader than previously thought and is ideally suited to finding the lowest-mass companions to hot subdwarf stars. The comparison with related binary populations shows that the period distribution of HW Vir systems is very similar to WD+dM systems and central stars of planetary nebula with cool companions. In the future, several new photometric surveys will be carried out, which will further increase the sample of this project, providing the potential to test many aspects of common-envelope theory and binary evolution.
EVR-CB-001: An Evolving, Progenitor, White Dwarf Compact Binary Discovered with the Evryscope
(2019)
We present EVR-CB-001, the discovery of a compact binary with an extremely low-mass (0.21 +/- 0.05M(circle dot)) helium core white dwarf progenitor (pre-He WD) and an unseen low-mass (0.32 +/- 0.06M(circle dot)) helium white dwarf (He WD) companion. He WDs are thought to evolve from the remnant helium-rich core of a main-sequence star stripped during the giant phase by a close companion. Low-mass He WDs are exotic objects (only about 0.2% of WDs are thought to be less than 0.3 M-circle dot), and are expected to be found in compact binaries. Pre-He WDs are even rarer, and occupy the intermediate phase after the core is stripped, but before the star becomes a fully degenerate WD and with a larger radius (approximate to 0.2R(circle dot)) than a typical WD. The primary component of EVR-CB-001 (the pre-He WD) was originally thought to be a hot subdwarf (sdB) star from its blue color and under-luminous magnitude, characteristic of sdBs. The mass, temperature (T-eff = 18,500 +/- 500 K), and surface gravity (log(g) = 4.96 +/- 0.04) solutions from this work are lower than values for typical hot subdwarfs. The primary is likely to be a post-red-giant branch, pre-He WD contracting into a He WD, and at a stage that places it nearest to sdBs on color-magnitude and T-eff-log(g) diagrams. EVR-CB-001 is expected to evolve into a fully double degenerate, compact system that should spin down and potentially evolve into a single hot subdwarf star. Single hot subdwarfs are observed, but progenitor systems have been elusive.
Arctic warming was more pronounced than warming in midlatitudes in the last decades making this region a hotspot of climate change. Associated with this, a rapid decline of sea-ice extent and a decrease of its thickness has been observed. Sea-ice retreat allows for an increased transport of heat and momentum from the ocean up to the tropo- and stratosphere by enhanced upward propagation of planetary-scale atmospheric waves. In the upper atmosphere, these waves deposit the momentum transported, disturbing the stratospheric polar vortex, which can lead to a breakdown of this circulation with the potential to also significantly impact the troposphere in mid- to late-winter and early spring. Therefore, an accurate representation of stratospheric processes in climate models is necessary to improve the understanding of the impact of retreating sea ice on the atmospheric circulation. By modeling the atmospheric response to a prescribed decline in Arctic sea ice, we show that including interactive stratospheric ozone chemistry in atmospheric model calculations leads to an improvement in tropo-stratospheric interactions compared to simulations without interactive chemistry. This suggests that stratospheric ozone chemistry is important for the understanding of sea ice related impacts on atmospheric dynamics.
We studied bacterial abundance and community structure of five soil cores using high-throughput sequencing of the 16S rRNA gene. Shifts in the soil bacterial composition were more pronounced within a vertical profile than across the landscape. Soil organic carbon (SOC) and nitrogen (N) concentrations decreased exponentially with soil depth and revealed a buried carbon-rich horizon between 0.8 and 1.3 m across all soil cores. This buried horizon was phylogenetically similar to its surrounding subsoils supporting the idea that the type of carbon, not necessarily the amount of carbon was driving the apparent similarities. In contrast to other studies, Nitrospirae was one of our major phyla with relatively high abundances throughout the soil profile except for the surface soil. Although depth is the major driver shaping soil bacterial community structure, positive correlations with SOC and N concentrations, however, were revealed with the bacterial abundance of Acidobacteria, one of the major, and Gemmatimonadetes, one of the minor phyla in our study. Our study showed that bacterial diversity in soils below 2.0 m can be still as high if not higher than in the above laying subsurface soil suggesting that various bacteria throughout the soil profile influence major biogeochemical processes in floodplain soils.
Influenza A viruses (IAV) are zoonotic pathogens relevant to human, domestic animal and wildlife health. Many avian IAVs are transmitted among waterfowl via a faecal-oral-route. Therefore, environmental water where waterfowl congregate may play an important role in the ecology and epidemiology of avian IAV. Water and sediment may sustain and transmit virus among individuals or species. It is unclear at what concentrations waterborne viruses are infectious or remain detectable. To address this, we performed lake water and sediment dilution experiments with varying concentrations or infectious doses of four IAV strains from seal, turkey, duck and gull. To test for infectivity of the IAV strains in a concentration dependent manner, we applied cultivation to specific pathogen free (SPF) embryonated chicken eggs and Madin-Darby Canine Kidney (MDCK) cells. IAV recovery was more effective from embryonated chicken eggs than MDCK cells for freshwater lake dilutions, whereas, MDCK cells were more effective for viral recovery from sediment samples. Low infectious dose (1 PFU/200 mu L) was sufficient in most cases to detect and recover IAV from lake water dilutions. Sediment required higher initial infectious doses (>= 100 PFU/200 mu L).
We investigated inflow of a wastewater treatment plant and sediment of an urban lake for the presence of Clostridioides difficile by cultivation and PCR. Among seven colonies we sequenced the complete genomes of three: two non-toxigenic isolates from wastewater and one toxigenic isolate from the urban lake. For all obtained isolates, a close genomic relationship with human-derived isolates was observed. (C) 2019 Elsevier Ltd. All rights reserved.
For a finite measure space X, we characterize strongly continuous Markov lattice semigroups on Lp(X) by showing that their generator A acts as a derivation on the dense subspace D(A)L(X). We then use this to characterize Koopman semigroups on Lp(X) if X is a standard probability space. In addition, we show that every measurable and measure-preserving flow on a standard probability space is isomorphic to a continuous flow on a compact Borel probability space.
Based on data from the ESA Gaia Data Release 2 (DR2) and several ground-based, multi-band photometry surveys we have compiled an all-sky catalogue of 39 800 hot subluminous star candidates selected in Gaia DR2 by means of colour, absolute magnitude, and reduced proper motion cuts. We expect the majority of the candidates to be hot subdwarf stars of spectral type B and O, followed by blue horizontal branch stars of late B-type (HBB), hot post-AGB stars, and central stars of planetary nebulae. The contamination by cooler stars should be about 10%. The catalogue is magnitude limited to Gaia G < 19 mag and covers the whole sky. Except within the Galactic plane and LMC/SMC regions, we expect the catalogue to be almost complete up to about 1.5 kpc. The main purpose of this catalogue is to serve as input target list for the large-scale photometric and spectroscopic surveys which are ongoing or scheduled to start in the coming years. In the long run, securing a statistically significant sample of spectroscopically confirmed hot subluminous stars is key to advance towards a more detailed understanding of the latest stages of stellar evolution for single and binary stars.
Non-predatory mortality of zooplankton provides an abundant, yet, little studied source of high quality labile organic matter (LOM) in aquatic ecosystems. Using laboratory microcosms, we followed the decomposition of organic carbon of fresh C-13-labelled Daphnia carcasses by natural bacterioplankton. The experimental setup comprised blank microcosms, that is, artificial lake water without any organic matter additions (B), and microcosms either amended with natural humic matter (H), fresh Daphnia carcasses (D) or both, that is, humic matter and Daphnia carcasses (HD). Most of the carcass carbon was consumed and respired by the bacterial community within 15 days of incubation. A shift in the bacterial community composition shaped by labile carcass carbon and by humic matter was observed. Nevertheless, we did not observe a quantitative change in humic matter degradation by heterotrophic bacteria in the presence of LOM derived from carcasses. However, carcasses were the main factor driving the bacterial community composition suggesting that the presence of large quantities of dead zooplankton might affect the carbon cycling in aquatic ecosystems. Our results imply that organic matter derived from zooplankton carcasses is efficiently remineralized by a highly specific bacterial community, but does not interfere with the bacterial turnover of more refractory humic matter.
Short period double degenerate white dwarf (WD) binaries with periods of less than similar to 1 day are considered to be one of the likely progenitors of type Ia supernovae. These binaries have undergone a period of common envelope evolution. If the core ignites helium before the envelope is ejected, then a hot subdwarf remains prior to contracting into a WD. Here we present a comparison of two very rare systems that contain two hot subdwarfs in short period orbits. We provide a quantitative spectroscopic analysis of the systems using synthetic spectra from state-of-the-art non-LTE models to constrain the atmospheric parameters of the stars. We also use these models to determine the radial velocities, and thus calculate dynamical masses for the stars in each system.
We provide explicit examples of positive and power-bounded operators on c(0) and l(infinity) which are mean ergodic but not weakly almost periodic. As a consequence we prove that a countably order complete Banach lattice on which every positive and power-bounded mean ergodic operator is weakly almost periodic is necessarily a KB-space. This answers several open questions from the literature. Finally, we prove that if T is a positive mean ergodic operator with zero fixed space on an arbitrary Banach lattice, then so is every power of T .
Across a landscape, aquatic-terrestrial interfaces within and between ecosystems are hotspots of organic matter (OM) mineralization. These interfaces are characterized by sharp spatio-temporal changes in environmental conditions, which affect OM properties and thus control OM mineralization and other transformation processes. Consequently, the extent of OM movement at and across aquatic-terrestrial interfaces is crucial in determining OM turnover and carbon (C) cycling at the landscape scale. Here, we propose expanding current concepts in aquatic and terrestrial ecosystem sciences to comprehensively evaluate OM turnover at the landscape scale. We focus on three main concepts toward explaining OM turnover at the landscape scale: the landscape spatiotemporal context, OM turnover described by priming and ecological stoichiometry, and anthropogenic effects as a disruptor of natural OM transfer magnitudes and pathways. A conceptual framework is introduced that allows for discussing the disparities in spatial and temporal scales of OM transfer, changes in environmental conditions, ecosystem connectivity, and microbial-substrate interactions. The potential relevance of priming effects in both terrestrial and aquatic systems is addressed. For terrestrial systems, we hypothesize that the interplay between the influx of OM, its corresponding elemental composition, and the elemental demand of the microbial communities may alleviate spatial and metabolic thresholds. In comparison, substrate level OM dynamics may be substantially different in aquatic systems due to matrix effects that accentuate the role of abiotic conditions, substrate quality, and microbial community dynamics. We highlight the disproportionate impact anthropogenic activities can have on OM cycling across the landscape. This includes reversing natural OM flows through the landscape, disrupting ecosystem connectivity, and nutrient additions that cascade across the landscape. This knowledge is crucial for a better understanding of OM cycling in a landscape context, in particular since terrestrial and aquatic compartments may respond differently to the ongoing changes in climate, land use, and other anthropogenic interferences.
In this work we tackle the problem of checking strong equivalence of logic programs that may contain local auxiliary atoms, to be removed from their stable models and to be forbidden in any external context. We call this property projective strong equivalence (PSE). It has been recently proved that not any logic program containing auxiliary atoms can be reformulated, under PSE, as another logic program or formula without them – this is known as strongly persistent forgetting. In this paper, we introduce a conservative extension of Equilibrium Logic and its monotonic basis, the logic of Here-and-There, in which we deal with a new connective ‘|’ we call fork. We provide a semantic characterisation of PSE for forks and use it to show that, in this extension, it is always possible to forget auxiliary atoms under strong persistence. We further define when the obtained fork is representable as a regular formula.
A distinguishing feature of Answer Set Programming is that all atoms belonging to a stable model must be founded. That is, an atom must not only be true but provably true. This can be made precise by means of the constructive logic of Here-and-There, whose equilibrium models correspond to stable models. One way of looking at foundedness is to regard Boolean truth values as ordered by letting true be greater than false. Then, each Boolean variable takes the smallest truth value that can be proven for it. This idea was generalized by Aziz to ordered domains and applied to constraint satisfaction problems. As before, the idea is that a, say integer, variable gets only assigned to the smallest integer that can be justified. In this paper, we present a logical reconstruction of Aziz’ idea in the setting of the logic of Here-and-There. More precisely, we start by defining the logic of Here-and-There with lower bound founded variables along with its equilibrium models and elaborate upon its formal properties. Finally, we compare our approach with related ones and sketch future work.
In a recent line of research, two familiar concepts from logic programming semantics (unfounded sets and splitting) were extrapolated to the case of epistemic logic programs. The property of epistemic splitting provides a natural and modular way to understand programs without epistemic cycles but, surprisingly, was only fulfilled by Gelfond's original semantics (G91), among the many proposals in the literature. On the other hand, G91 may suffer from a kind of self-supported, unfounded derivations when epistemic cycles come into play. Recently, the absence of these derivations was also formalised as a property of epistemic semantics called foundedness. Moreover, a first semantics proved to satisfy foundedness was also proposed, the so-called Founded Autoepistemic Equilibrium Logic (FAEEL). In this paper, we prove that FAEEL also satisfies the epistemic splitting property something that, together with foundedness, was not fulfilled by any other approach up to date. To prove this result, we provide an alternative characterisation of FAEEL as a combination of G91 with a simpler logic we called Founded Epistemic Equilibrium Logic (FEEL), which is somehow an extrapolation of the stable model semantics to the modal logic S5.
A common feature in Answer Set Programming is the use of a second negation, stronger than default negation and sometimes called explicit, strong or classical negation. This explicit negation is normally used in front of atoms, rather than allowing its use as a regular operator. In this paper we consider the arbitrary combination of explicit negation with nested expressions, as those defined by Lifschitz, Tang and Turner. We extend the concept of reduct for this new syntax and then prove that it can be captured by an extension of Equilibrium Logic with this second negation. We study some properties of this variant and compare to the already known combination of Equilibrium Logic with Nelson's strong negation.
Answer Set Programming (ASP) has become a popular and widespread paradigm for practical Knowledge Representation thanks to its expressiveness and the available enhancements of its input language. One of such enhancements is the use of aggregates, for which different semantic proposals have been made. In this paper, we show that any ASP aggregate interpreted under Gelfond and Zhang's (GZ) semantics can be replaced (under strong equivalence) by a propositional formula. Restricted to the original GZ syntax, the resulting formula is reducible to a disjunction of conjunctions of literals but the formulation is still applicable even when the syntax is extended to allow for arbitrary formulas (including nested aggregates) in the condition. Once GZ-aggregates are represented as formulas, we establish a formal comparison (in terms of the logic of Here-and-There) to Ferraris' (F) aggregates, which are defined by a different formula translation involving nested implications. In particular, we prove that if we replace an F-aggregate by a GZ-aggregate in a rule head, we do not lose answer sets (although more can be gained). This extends the previously known result that the opposite happens in rule bodies, i.e., replacing a GZ-aggregate by an F-aggregate in the body may yield more answer sets. Finally, we characterize a class of aggregates for which GZ- and F-semantics coincide.