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We show a Lefschetz fixed point formula for holomorphic functions in a bounded domain D with smooth boundary in the complex plane. To introduce the Lefschetz number for a holomorphic map of D, we make use of the Bergman kernal of this domain. The Lefschetz number is proved to be the sum of usual contributions of fixed points of the map in D and contributions of boundary fixed points, these latter being different for attracting and repulsing fixed points.
Small-subunit (SSU) rRNA genes (rDNA) were amplified by PCR from a hot pool environmental DNA sample using Bacteria- or Archaea-specific rDNA primers. Unique rDNA types were identified by restriction fragment length polymorphism (RFLP) analysis and representative sequences were determined. Family 10 glycoside hydrolase consensus PCR primers were used to explore the occurrence and diversity of xylanase genes in the hot pool environmental DNA sample. Partial sequences for three different xylanases were obtained and genomic walking PCR (GWPCR), in combination with nested primer pairs, was used to obtained a unique 1,741-bp nucleotide sequence. Analysis of this sequence identified a putative XynA protein encoded by the xynA open reading frame. The single module novel xylanase shared sequence similarity to the family 10 glycoside hydrolases. The purified recombinant enzyme, XynA expressed in E. coli exhibited optimum activity at 100 degrees C and pH 6.0, and was extremely thermostable at 90 degrees C. The enzyme showed high specificity toward different xylans and xylooligosaccharides.
After reviewing the research on Saxon regionalized intonation and giving an overview of our research project on regionalized intonation in German, a particular salient regionalized intonation contour from the Dresden vernacular is described in detail. In addition to a more widespread contour that is also used in the Berlin vernacular, albeit in different contexts, the so-called 'upward staircase contour' which is formed by a lower plateau, a rise and a higher plateau, the Dresden vernacular also uses very salient regionalized variants of such staircase contours: These variants entail upward staircases with, metaphorically speaking, two steps; i.e. after the lower plateau and the rise up to a higher plateau, the pitch rises up again in order to form a third plateau. Depending upon the alignment of the second rise and the third plateau, with only the final unaccented syllable of the intonation phrase or with the nuclear accented syllable and the following tail, the contour needs to be distinguished, yielding either an 'upward staircase with an additional final rise plateau' or a 'double upward staircase'. These two contours are shown to be used in different conversational contexts and in different functions in the Dresden vernacular. - Data for this study come from natural speech by speakers of the Dresden vernacular. The phonetic and phonological analysis of the contour is based on auditive, acoustic-phonetic and phonological methodology; the functional analysis of the utterances with the salient contours relies on the techniques of conversation analysis
Acclimatization
(2003)
Together with their wives Otto and Richard Schomburgk arrived in Port Adelaide (South Australia) on August 16th 1849. The essay looks at how these two brothers, who had received their scientific training and promotion in the circle surrounding Alexander von Humboldt, reacted to the unfamiliar conditions in the young British colony. Some indication will be given as to the differences between the Schomburgk brothers treatment of the natural resources of the new colony and that of the English colonists of the time.
Adult education on quality management and other cross-selectional aspects of public administration
(2003)
Electro-chemical signal transduction is the basis of communication between n eurons and their target cells. An important group of neuroactive substances that are released by action potentials from neurons are the biogenic amines. These a re small organic molecules that bind to specific receptors located in the target cell membrane. Once activated these receptors cause changes in the intracellula r concentration of second messengers, i.e. cyclic nucleotides, phosphoinositides , or Ca2+, leading to slow but long-lasting cellular responses. Biochemical, pha rmacological, physiological, and molecular biological approaches have unequivoca lly shown that biogenic amines are important regulators of cellular function in both vertebrates and invertebrates. In this review, we will concentrate on the p roperties of two biogenic amines and their receptors that were originally identi fied in invertebrates: tyramine and octopamine.
As a non-contact process laser beam melt ablation offers several advantages compared to conventional processing mechanisms. During ablation the surface of the workpiece is molten by the energy of a CO2-laser beam, this melt is then driven out by the impulse of an additional process gas. Although the idea behind laser beam melt ablation is rather simple, the process itself has a major limitation in practical applications: with increasing ablation rate surface quality of the workpiece processed declines rapidly. With different ablation rates different surface structures can be distinguished, which can be characterised by suitable surface parameters. The corresponding regimes of pattern formation are found in linear and non-linear statistical properties of the recorded process emissions as well. While the ablation rate can be represented in terms of the line-energy, this parameter does not provide sufficient information about the full behaviour of the system. The dynamics of the system is dominated by oscillations due to the laser cycle but includes some periodically driven non-linear processes as well. Upon the basis of the measured time series, a corresponding model is developed. The deeper understanding of the process can be used to develop strategies for a process control.
An educational program for parents of asthmatic preschool children: Short and medium-Term Effects.
(2003)
The development of fast and reliable biochemical tools for on-site screening in environmental analysis was the main target of the present work. Due to various hazardous effects such as endocrine disruption and toxicity phenolic compounds are key analytes in environmental analysis and thus were chosen as model analytes. Three different methods were developed: For the enzymatic detection of phenols in environmental samples an enzyme-based biosensor was developed. In contrast to reported work using tyrosinase or peroxidases, we developed a biosensor based on glucose dehydrogenase as biorecognition element. This biosensor was devoted for an application in a laboratory flow system as well as in a portable device for on-site measurements. This enzymatic detection is applicable only for a limited number of phenols due to substrate specificity of the enzyme. For other relevant compounds based on a phenolic structure (i.e. nitrophenol, alkylphenols and alkylphenol ethoxylates) immunological methods had to be developed. The electrochemical GDH-biosensor was used as the label detector in these immunoassays. Two heterogeneous immunoassays were developed where ßGal was used as the label. An electrochemical method for the determination of the marker enzyme activity was processed. The separation step was realized with protein A/G columns (laboratory flow system) or by direct immobilization of the antibodies in small disposable capillaries (on-site analysis). All methods were targeted on the contemporary analysis of small numbers of samples.
Dopamine is found in many invertebrate organisms, including insects, however, the mechanisms through which this amine operates remain unclear. We have expressed two dopamine receptors cloned from honey bee (AmDOP1 and AmDOP2) in insect cells (Spodoptera frugiperda), and compared their pharmacology directly using production of cAMP as a functional assay. In each assay, AmDOP1 receptors required lower concentrations of dopamine and 6,7-ADTN for maximal activation than AmDOP2 receptors. Conversely, butaclamol and cis(Z)-flupentixol were more potent at blocking the cAMP response mediated through AmDOP2 than AmDOP1 receptors. Expression of AmDOP1, but not AmDOP2, receptors significantly increased levels of cAMP even in the absence of ligand. This constitutive activity was blocked by cis(Z)-flupentixol. This work provides the first evidence of a constitutively activated dopamine receptor in invertebrates and suggests that although AmDOP1 and AmDOP2 share much less homology than their vertebrate counterparts, they display a number of functional parallels with the mammalian D1-like dopamine receptors.
Application of metabolomics to plant genotype discrimination using statistics and machine learning
(2003)
Results of an inter-laboratory round-robin study of the application of time-resolved emission spectroscopy (TRES) to the speciation of uranium(VI) in aqueous media are presented. The round-robin study involved 13 independent laboratories, using various instrumentation and data analysis methods. Samples were prepared based on appropriate speciation diagrams and, in general, were found to be chemically stable for at least six months. Four different types of aqueous uranyl solutions were studied: (1) acidic medium where UO22+aq is the single emitting species, (2) uranyl in the presence of fluoride ions, (3) uranyl in the presence of sulfate ions, and (4) uranyl in aqueous solutions at different pH, promoting the formation of hydrolyzed species. Results between the laboratories are compared in terms of the number of decay components, luminescence lifetimes, and spectral band positions. The successes and limitations of TRES in uranyl analysis and speciation in aqueous solutions are discussed.
Arundati Roy's the God of small things : identity construction between indianness and britishness
(2003)
Boundary value problems on manifolds with conical singularities or edges contain potential operators as well as trace and Green operators which play a similar role as the corresponding operators in (pseudo-differential) boundary value problems on a smooth manifold. There is then a specific asymptotic behaviour of these operators close to the singularities. We characterise potential operators in terms of actions of cone or edge pseudo-differential operators (in the neighbouring space) on densities supported by sbmanifolds which also have conical or edge singularities. As a byproduct we show the continuity of such potentials as continuous perators between cone or edge Sobolev spaces and subspaces with asymptotics.
In this study, a method for partly automated sample preparation and fully automated solid-phase extraction method for plasma, kidney and liver samples for various retinoids like all-trans-4-oxo-retinoic acid, 13-cis-4-oxo- retinoic acid, 13-cis-retinoic acid, 9-cis-retinoic acid, all-trans-retinoic acid, retinol and retinyl palmitate was established. Plasma, embryo-, kidney-and liver-homogenates were automatically mixed and extracted on multiple usage solid-phase (C2) extraction cartridges immediately before HPLC analysis. Automated cleaning, preconditioning and incorporation of the loaded cartridge to fully automated HPLC separation and quantification of the various retinoids in a single HPLC run was established. The recovery of the retinoids was generally between 80 and 90%. Intra-day repeatability was <11.7%. As little as 1.2 ng/ml could be quantified in lipid-mixture standard samples. This method allows a highly automated sample preparation and a fully automated solid-phase extraction with good selectivity for the study of endogenous retinoids and retinoids after nutritional supplementations and pharmacological applications in several biological samples. (C) 2003 Elsevier B.V. All rights reserved
In recent years most studies of the benthic microbial food web have either been descriptive or were restricted to the measurement of within sediment process rates. Little is known about benthic-pelagic coupling processes such as recruitment. We, therefore, developed an ex situ core incubation procedure to quantify the potential for microbial recruitment from the benthos to the pelagic in an acidic mining lake, Mining Lake 111 (ML 111; pH 2.6), in eastern Germany. Our data suggest that considerable zooplankton recruitment from the benthos takes place. Heliozoan and rhizopod recruitment in both summer and winter sediment cores was highest when they were incubated at 20°C. Maximum heliozoan recruitment was 23 (± 9 s.e.) individuals cm-2 d-1 (40% initial standing stock daily) in the winter 20°C incubation. Maximum rhizopod recruitment was 6 (± 2 s.e.) individuals cm-2 d-1 in the summer 20°C incubation. Little or no recruitment was apparent for either taxa when winter cores were incubated at 5°C, implying a temperature cue. Conversely, the rotifer, Cephalodella hoodi, exhibited a maximum recruitment of 6 (± 2 s.e.) individuals cm-2 d-1 during the winter 5°C incubation, representing 30% of initial standing stock daily, but little recruitment when incubated at 20°C. Cephalodella may have responded to an increased winter benthic food supply; in situ winter Chl a concentrations in the benthos were 3.4 times higher than those in the summer. The importance of this was reinforced by the poor pelagic food supply available in ML 111. In situ, Heliozoa, rhizopods and Cephalodella were first observed in the epilimnion of ML 111 in spring or early summer, suggesting active or passive recruitment following lateral transport from littoral sediments. Benthic-pelagic coupling via recruitment is potentially important in understanding the pelagic food web in ML 111 and warrants further investigation in this and other aquatic environments.
Late Miocene to Quaternary volcanic rocks from the frontal arc to the back-arc region of the Central Volcanic Zone in the Andes show a wide range of delta 11B values (+4 to -7 ‰) and boron concentrations (6 to 60 ppm). Positive delta 11B values of samples from the volcanic front indicate involvement of a 11B-enriched slab component, most likely derived from altered oceanic crust, despite the thick Andean continental lithosphere, and rule out a pure crust-mantle origin for these lavas. The delta 11B values and B concentrations in the lavas decrease systematically with increasing depth of the Wadati-Benioff Zone. This across-arc variation in delta 11B values and decreasing B/Nb ratios from the arc to the back-arc samples are attributed to the combined effects of B-isotope fractionation during progressive dehydration in the slab and a steady decrease in slab-fluid flux towards the back arc, coupled with a relatively constant degree of crustal contamination as indicated by similar Sr, Nd and Pb isotope ratios in all samples. Modelling of fluid-mineral B-isotope fractionation as a function of temperature fits the across-arc variation in delta 11B and we conclude that the B-isotope composition of arc volcanics is dominated by changing delta 11B composition of B-rich slab-fluids during progressive dehydration. Crustal contamination becomes more important towards the back-arc due to the decrease in slab-derived fluid flux. Because of this isotope fractionation effect, high delta 11B signatures in volcanic arcs need not necessarily reflect differences in the initial composition of the subducting slab. Three-component mixing calculations for slab-derived fluid, the mantle wedge and the continental crust based on B, Sr and Nd isotope data indicate that the slab-fluid component dominates the B composition of the fertile mantle and that the primary arc magmas were contaminated by an average addition of 15 to 30 % crustal material.
In the recent literature there is a hypothesis that the human parser uses number and case information in different ways to resolve an initially incorrect case assignment. This paper investigates what role morphological case information plays during the parser’s detection of an ungrammaticality or its recognition that a reanalysis is necessary. First, we compare double nominative with double accusative ungrammaticalities in a word by word, speeded grammaticality task and in this way show that only double nominatives lead to a so-called ”illusion of grammaticality” (a low rate of ungrammaticality detection). This illusion was found to disappear when the second argument was realized by a pronoun rather than by a full definite determiner phrase, i.e. when the saliency of the second argument was increased. Thus, the accuracy in recognizing an ungrammaticality induced by the case feature of the second argument is dependent on the type of this argument. Furthermore, we found that the accuracy in detecting such case ungrammaticalities is distance sensitive insofar as a shorter distance leads to a higher accuracy. The results are taken as support for an ”expectationdriven” parse strategy in which the way the parser uses the information of a current input item depends on the expectation resulting from the parse carried out so far. By contrast, ”input-driven” parse strategies, such as the diagnosis model (Fodor & Inoue, 1999) are unable to explain the data presented here.
The nuclear SHL protein is composed of a N-terminal BAH domain and a C-terminal PHD finger. Both domains are found in transcriptional regulators and chromatin-modifying proteins. Arabidopsis plants over-expressing SHL showed earlier flowering and senescence phenotype. To identify SHL regulated genes, expression profiles of 35S::SHL plants were established with Affymetrix ATH1 microarrays. About 130 genes showed reduced transcript levels, and about 45 genes showed increased transcript levels in 35S:: SHL plants. The up-regulated genes included AGL20 and AGL9, which most likely cause the early flowering phenotype of 35S:: SHL plants. Late-flowering SHL-antisense lines showed reduced AGL20 mRNA levels, suggesting that AGL20 gene expression depends on the SHL protein. The stronger expression of senescence- and defence-related genes (such as DIN2, DIN11 and PR-1) is in line with the early senescence phenotype of SHL-over- expressing plants. SHL-down-regulated genes included stress response genes and the PSR3.2 gene (encoding a beta- glucosidase). SHL over-expression did not alter the tissue specificity of PSR3.2 gene expression, but resulted in reduced transcript levels in both shoots and roots. Plants with glucocorticoid-inducible SHL over-expression were established and used for expression profiling as well. A subset of genes was identified, which showed consistent changes in the inducible system and in plants with constitutive SHL over-expression
Characterizing Grids
(2003)
We present a new data model approach to describe the various objects that either represent the Grid infrastructure or make use of it. The data model is based on the experiences and experiments conducted in heterogeneous Grid environments. While very sophisticated data models exist to describe and characterize e.g. compute capacities or web services, we will show that a general description, which combines {em all} of these aspects, is needed to give an adequate representation of objects on a Grid. The Grid Object Description Language (GODsL)} is a generic and extensible approach to unify the various aspects that an object on a Grid can have. GODsL provides the content for the XML based communication in Grid migration scenarios, carried out in the GridLab project. We describe the data model architecture on a general level and focus on the Grid application scenarios.
As a consequence of increasing winter rainfall totals and intensities over the second half of the 20th century, signs of increased flooding probability in many areas of the Rhine and Meuse basins have been documented. These changes affecting rainfall characteristics are most evidently due to an increase in westerly atmospheric circulation types. Land use changes, particularly urbanization, can have significant local effects in small basins (headwaters) with respect to flooding, especially during heavy local rainstorms, but no evidence exists that land use change has had significant effects on peak flows in the rivers Rhine and Meuse. For the 21st century, most global circulation models suggest higher winter rainfall totals. Most hydrological simulations of the Rhine-Meuse river basins suggest an increased flooding probability, with a progressive shift of the Rhine from a 'rain-fed/meltwater' river into a mainly 'rain-fed' river. A very limited effect of changes in land use on the discharge regime seems to exist for the main branches of the Meuse and Rhine rivers. For mesoscale basins, future changes in peak flows depend on the changes in the variability of extreme precipitations in combination with land use changes. Copyright (C) 2004 John Wiley Sons, Ltd
Clones of n-ary algebras
(2003)
Reassessment of local earthquake data from the ANCORP seismological network allowed the calculation of 3D attenuation (Q(p)) tomographic images of crust and upper mantle beneath the southern Bolivian Altiplano around 21degrees S. The images reveal a low-Q(p) middle and lower crust and a moderate-Q(p) upper mantle beneath the southern Altiplano. Beneath the recent magmatic arc, Q(p) is not significantly decreased at this latitude. The distribution of crustal Q(p) coincides with the variation of electrical resistivity, thus limiting the possible mechanisms causing the anomalies. Our findings support the hypothesis that partial melts in middle and lower crust beneath the Altiplano are present on a large scale. We see no evidence for a shallow asthenosphere beneath the southern Altiplano
Compact white-light source with an average output power of 2.4 W and 900 nm spectral bandwidth
(2003)
Higher variability in rainfall and river discharge could be of major importance in landslide generation in the north-western Argentine Andes. Annual layered (varved) deposits of a landslide dammed lake in the Santa Maria Basin (26°S, 66°W) with an age of 30,000 14C years provide an archive of precipitation variability during this time. The comparison of these data with present-day rainfall observations tests the hypothesis that increased rainfall variability played a major role in landslide generation. A potential cause of such variability is the El Niño/ Southern Oscillation (ENSO). The causal link between ENSO and local rainfall is quantified by using a new method of nonlinear data analysis, the quantitative analysis of cross recurrence plots (CRP). This method seeks similarities in the dynamics of two different processes, such as an ocean-atmosphere oscillation and local rainfall. Our analysis reveals significant similarities in the statistics of both modern and palaeo-precipitation data. The similarities in the data suggest that an ENSO-like influence on local rainfall was present at around 30,000 14C years ago. Increased rainfall, which was inferred from a lake balance modeling in a previous study, together with ENSO-like cyclicities could help to explain the clustering of landslides at around 30,000 14C years ago.
So far, text linguistics has not shown any particular interest in the topic of satire, which appears to be narrowly defined in the media text type "satirical commentary" and to need little clarification. This view overlooks the fact that a satirical press, making use of almost all available journalistic text types, has existed for a long time. The aspects of the analysis discussed in this article provide a justification for why research on satire should be undertaken not only in literary studies, but also in text linguistics
Biochemical and genetic regulatory systems that involve low concentrations of molecules are inherently noisy. This intrinsic stochasticity, has received considerable interest recently, leading to new insights about the sources and consequences of noise in complex systems of genetic regulation. However, most prior work was devoted to the reduction of fluctuation and the robustness of cellular function with respect to intrinsic noise. Here, we focus on several scenarios in which the inherent molecular fluctuations are not merely a nuisance, but act constructively and bring about qualitative changes in the dynamics of the system. It will be demonstrated that in many typical situations biochemical and genetic regulatory systems may utilize intrinsic noise to their advantage. (C) 2002 Elsevier Ireland Ltd. All rights reserved
Core-Modified Hexaphyrins; Characterization of Two- and Four-Ring Inverted 26 ô Aromatic Macrocycles
(2003)
In this thesis the gravitational lensing effect is used to explore a number of cosmological topics. We determine the time delay in the gravitationally lensed quasar system HE1104-1805 using different techniques. We obtain a time delay Delta_t(A-B) Delta_t(A-B) =-310 +- 20 days (2 sigma errors) between the two components. We also study the double quasar Q0957+561 during a three years monitoring campaign. The fluctuations we find in the difference light curves are completely consistent with noise and no microlensing is needed to explain these fluctuations. Microlensing is also studied in the quadruple quasar Q2237+0305 during the GLITP collaboration (Oct.1999-Feb.2000). We use the absence of a strong microlensing signal to obtain an upper limit of v=600 km/s for the effective transverse velocity of the lens galaxy (considering microlenses with 0.1 solar masses). The distribution of dark matter in galaxy clusters is also studied in the second part of the thesis. In the cluster of galaxies Cl0024+1654 we obtain a mass-to-light ratio of M/L = 200 M_sun/L_sun (within a radius of 3 arcminutes). In the galaxy cluster RBS380 we find a relatively low X-ray luminosity for a massive cluster of L =2*10^(44) erg/s, but a rich distribution of galaxies in the optical band.
Counting Markedness
(2003)
This paper reports the results of a corpus investigation on case conflicts in German argument free relative constructions. We investigate how corpus frequencies reflect the relative markedness of free relative and correlative constructions, the relative markedness of different case conflict configurations, and the relative markedness of different conflict resolution strategies. Section 1 introduces the conception of markedness as used in Optimality Theory. Section 2 introduces the facts about German free relative clauses, and section 3 presents the results of the corpus study. By and large, markedness and frequency go hand in hand. However, configurations at the highest end of the markedness scale rarely show up in corpus data, and for the configuration at the lowest end we found an unexpected outcome: the more marked structure is preferred.
We investigate crack problems, where the crack boundary has conical singularities. Elliptic operators with two-sided elliptc boundary conditions on the plus and minus sides of the crack will be interpreted as elements of a corner algebra of boundary value problems. The corresponding operators will be completed by extra edge conditions on the crack boundary to Fredholm operators in corner Sobolev spaces with double weights, and there are parametrices within the calculus.
Oases is a special ecosystem formed in arid climate and hungriness environment, in which resident, water and soil are the principal factor and exchanges of materials, energy and information are the main functional characteristics. The oases regions in central Asia are not only the basilic cradle of civilization of human beings, but also the important strategic places in world growing awareness of the potential benefits. We choose Keriya River Basin oases in south of Xinjiang as a case to study critical controlling of Oases Evolution, Based on the theories and methods used for environmental geology, physical geography, land resource research, and oases ecology. This study try to indicate the essential factors driving the oases ecosystem and the interactional dynamic mechanism in different scales and levels, confirm the optimal equilibrium aggregate of harmonious development between Population, Resources, Environment and Development, and establish the critical controlling pattern of sustainable development. We advance the indicator system to research the evolution of the PRED System of oases in Keriya River valley oases, in basis of the information derived from the field investigation and local materials. According to inquisitional result based on technical support of Geographic Information System (GIS) and Remote Sense (RS), the comparisons and analyses are carried out in land use at the upper reaches, vegetation change in the middle reaches, and desertification at the lower reaches, which narrates the regulations of Keriya River Valley oases land cover dynamic change. The main land cover types represent distinct characteristics of the local place. On the basis of field survey and statistical data, we use ARCINFO software to preprocess these data and the 2 TM satellite images. Through analyzing these images resulting from post- classification compare, we sums up the concrete quantificational dynamic distributed data of 13 land types covering a span of 15 years and regulation of the local ecological environment system. It finally points out that the trend of Keriya River Valley oases desertification expansion is mainly related to two important reasons: impact of natural environment and impact of human activities.
The colloidal systems are present everywhere in many varieties such as emulsions (liquid droplets dispersed in liquid), aerosols (liquid dispersed in gas), foam (gas in liquid), etc. Among several new methods for the preparation of colloids, the so-called miniemulsion technique has been shown to be one of the most promising. Miniemulsions are defined as stable emulsions consisting of droplets with a size of 50-500 nm by shearing a system containing oil, water, a surfactant, and a highly water insoluble compound, the so-called hydrophobe 1. In the first part of this work, dynamic crystallization and melting experiments are described which were performed in small, stable and narrowly distributed nanodroplets (confined systems) of miniemulsions. Both regular and inverse systems were examined, characterizing, first, the crystallization of hexadecane, secondly, the crystallization of ice. It was shown for both cases that the temperature of crystallization in such droplets is significantly decreased (or the required undercooling is increased) as compared to the bulk material. This was attributed to a very effective suppression of heterogeneous nucleation. It was also found that the required undercooling depends on the nanodroplet size: with decreasing droplet size the undercooling increases. 2. It is shown that the temperature of crystallization of other n-alkanes in nanodroplets is also significantly decreased as compared to the bulk material due to a very effective suppression of heterogeneous nucleation. A very different behavior was detected between odd and even alkanes. In even alkanes, the confinement in small droplets changes the crystal structure from a triclinic (as seen in bulk) to an orthorhombic structure, which is attributed to finite size effects inside the droplets. An intermediate metastable rotator phase is of less relevance for the miniemulsion droplets than in the bulk. For odd alkanes, only a strong temperature shift compared to the bulk system is observed, but no structure change. A triclinic structure is formed both in bulk and in miniemulsion droplets. 3. In the next part of the thesis it is shown how miniemulsions could be successfully applied in the development of materials with potential application in pharmaceutical and medical fields. The production of cross-linked gelatin nanoparticles is feasible. Starting from an inverse miniemulsion, the softness of the particles can be controlled by varying the initial concentration, amount of cross-link agent, time of cross-linking, among other parameters. Such particles show a thermo-reversible effect, e.g. the particles swell in water above 37 °C and shrink below this temperature. Above 37 °C the chains loose the physical cross-linking, however the particles do not loose their integrity, because of the chemical cross-linking. Those particles have potential use as drug carriers, since gelatin is a natural polymer derived from collagen. 4. The cross-linked gelatin nanoparticles have been used for the biomineralization of hydroxyapatite (HAP), a biomineral, which is the major constituent of our bones. The biomineralization of HAP crystals within the gelatin nanoparticles results in a hybrid material, which has potential use as a bone repair material. 5. In the last part of this work we have shown that layers of conjugated semiconducting polymers can be deposited from aqueous dispersion prepared by the miniemulsion process. Dispersions of particles of different conjugated semiconducting polymers such as a ladder-type poly(para-phenylene) and several soluble derivatives of polyfluorene could be prepared with well-controlled particle sizes ranging between 70 - 250 nm. Layers of polymer blends were prepared with controlled lateral dimensions of phase separation on sub-micrometer scales, utilizing either a mixture of single component nanoparticles or nanoparticles containing two polymers. From the results of energy transfer it is demonstrated that blending two polymers in the same particle leads to a higher efficiency due to the better contact between the polymers. Such an effect is of great interest for the fabrication of opto-electronic devices such as light emitting diodes with nanometer size emitting points and solar cells comprising of blends of electron donating and electron accepting polymers.
Defining britishhness from the margins : Peter Weir's gallipoli and hugh hudson's chariots of fire
(2003)
Detection of different land degradation stages in semi-arid grassland areas in Souhtern Africa
(2003)
The progesterone concentration in blood samples can be utilised as a marker for the diagnosis of early pregnancy, endocrinopathy and virilism. Here, we describe a method for progesterone detection and measurement in whole blood samples by a surface sensitive biosensor used in conjunction with an integrated optical grating coupler. This device determines refractive index changes near the biosensor's surface. Hence, biological species bound to a surface layer can be measured in real-time without any label. For the measurements, we have modified the indirect competitive immonoassay principle. The concentration of the progesterone antibody was kept at 1 µg/ml. Progesterone concentration was determined in buffer solution and whole blood in a range between 0.005 and 10 ng/ml. The detection limit was determined to be 3 pM. The relative standard deviation was calculated to be 3.5%.
The Barbara Petchenik Award was created by the International Cartographic Association in 1993. The aims of the competition are to promote childrens creative representation of the world, to enhance their cartographic awareness and to make them more conscious of their environment. Every two years a lot of children from all over the world take part in this competition. The national committee for organizing the competition in Germany collected and archieved all of the german entries since 1993. The evaluation of the childrens maps takes place continuous and get an insight into the cartogaphic and spatial comprehension of the children. The favourite subjects of the paintings depend on the age of children and current occurrences during the time of making the maps (map as document of the times). Designing an own map requires a good knowledge of cartographic rules. Therefor especially the creation of thematic maps shows very clear the stage of development of childrens cartographic education and spatial ideas. The connection of their selected subjects with the map design is very different. Either the most imaginative created subject in a way of a picture or the exact cartographic design comes to the fore. In some cases were noticed a very good combination between figurative and cartographic expression with a high harmony of a recognizable message and cartographic content. A development of cartographic and spatial comprehension in general can be seen, but the childrens maps waver between reality and fantasy.
Contents: Chapter 1: Localization (Surgery) in Elliptic Theory 1.1. The Index Locality Principle 1.1.1. What is locality? 1.1.2. A pilot example 1.1.3. Collar spaces 1.1.4. Elliptic operators 1.1.5. Surgery and the relative index theorem 1.2. Surgery in Index Theory on Smooth Manifolds 1.2.1. The Booß–Wojciechowski theorem 1.2.2. The Gromov–Lawson theorem 1.3. Surgery for Boundary Value Problems 1.3.1. Notation 1.3.2. General boundary value problems 1.3.3. A model boundary value problem on a cylinder 1.3.4. The Agranovich–Dynin theorem 1.3.5. The Agranovich theorem 1.3.6. Bojarski’s theorem and its generalizations 1.4. (Micro)localization in Lefschetz theory 1.4.1. The Lefschetz number 1.4.2. Localization and the contributions of singular points 1.4.3. The semiclassical method and microlocalization 1.4.4. The classical Atiyah–Bott–Lefschetz theorem
Contents: Chapter 3: Eta Invariant and the Spectral Flow 3.1. Introduction 3.2. The Classical Spectral Flow 3.2.1. Definition and main properties 3.2.2. The spectral flow formula for periodic families 3.3. The Atiyah–Patodi–Singer Eta Invariant 3.3.1. Definition of the eta invariant 3.3.2. Variation under deformations of the operator 3.3.3. Homotopy invariance. Examples 3.4. The Eta Invariant of Families with Parameter (Melrose’s Theory) 3.4.1. A trace on the algebra of parameter-dependent operators 3.4.2. Definition of the Melrose eta invariant 3.4.3. Relationship with the Atiyah–Patodi–Singer eta invariant 3.4.4. Locality of the derivative of the eta invariant. Examples 3.5. The Spectral Flow of Families of Parameter-Dependent Operators 3.5.1. Meromorphic operator functions. Multiplicities of singular points 3.5.2. Definition of the spectral flow 3.6. Higher Spectral Flows 3.6.1. Spectral sections 3.6.2. Spectral flow of homotopies of families of self-adjoint operators 3.6.3. Spectral flow of homotopies of families of parameter-dependent operators 3.7. Bibliographical Remarks
Contents: Chapter 4: Pseudodifferential Operators 4.1. Preliminary Remarks 4.1.1. Why are pseudodifferential operators needed? 4.1.2. What is a pseudodifferential operator? 4.1.3. What properties should the pseudodifferential calculus possess? 4.2. Classical Pseudodifferential Operators on Smooth Manifolds 4.2.1. Definition of pseudodifferential operators on a manifold 4.2.2. Hörmander’s definition of pseudodifferential operators 4.2.3. Basic properties of pseudodifferential operators 4.3. Pseudodifferential Operators in Sections of Hilbert Bundles 4.3.1. Hilbert bundles 4.3.2. Operator-valued symbols. Specific features of the infinite-dimensional case 4.3.3. Symbols of compact fiber variation 4.3.4. Definition of pseudodifferential operators 4.3.5. The composition theorem 4.3.6. Ellipticity 4.3.7. The finiteness theorem 4.4. The Index Theorem 4.4.1. The Atiyah–Singer index theorem 4.4.2. The index theorem for pseudodifferential operators in sections of Hilbert bundles 4.4.3. Proof of the index theorem 4.5. Bibliographical Remarks
Contents: Chapter 5: Manifolds with Isolated Singularities 5.1. Differential Operators and the Geometry of Singularities 5.1.1. How do isolated singularities arise? Examples 5.1.2. Definition and methods for the description of manifolds with isolated singularities 5.1.3. Bundles. The cotangent bundle 5.2. Asymptotics of Solutions, Function Spaces,Conormal Symbols 5.2.1. Conical singularities 5.2.2. Cuspidal singularities 5.3. A Universal Representation of Degenerate Operators and the Finiteness Theorem 5.3.1. The cylindrical representation 5.3.2. Continuity and compactness 5.3.3. Ellipticity and the finiteness theorem 5.4. Calculus of ΨDO 5.4.1. General ΨDO 5.4.2. The subalgebra of stabilizing ΨDO 5.4.3. Ellipticity and the finiteness theorem
This paper argues that the texts surviving from the Old English period do not reflect the spoken language of the bulk of the population under Anglo-Saxon elite domination. While the Old English written documents suggest that the language was kept remarkably unchanged, i.e. was strongly monitored during the long OE period (some 500 years!), the spoken and "real Old English" is likely to have been very different and much more of the type of Middle English than the written texts. "Real Old Engish", i.e. of course only appeared in writing after the Norman Conquest. Middle English is therefore claimed to have begun with the 'late British' speaking shifters to Old English. The shift patterns must have differed in the various part of the island of Britain, as the shifters became exposed to further language contact with the Old Norse adstrate in the Danelaw areas and the Norman superstrate particularly in the South East, the South West having been least exposed to language contact after the original shift from 'Late British' to Old English. This explains why the North was historically the most innovative zone. This also explains the conservatism of the present day dialects in the South West. It is high time that historical linguists acknowledge the arcane character of the Old English written texts.
We present the first separate spectra of both components of the small-separation double QSO HE 0512-3329 obtained with HST/STIS in the optical and near UV. The similarities especially of the emission line profiles and redshifts strongly suggest that this system really consists of two lensed images of one and the same source. The emission line flux ratios are assumed to be unaffected by microlensing and are used to study the differential extinction effects caused by the lensing galaxy. Fits of empirical laws show that the extinction properties seem to be different on both lines of sight. With our new results, HE 0512-3329 becomes one of the few extragalactic systems which show the 2175 Å absorption feature, although the detection is only marginal. We then correct the continuum flux ratio for extinction to obtain the differential microlensing signal. Since this may still be significantly affected by variability and time-delay effects, no detailled analysis of the microlensing is possible at the moment. This is the first time that differential extinction and microlensing could be separated unambiguously. We show that, at least in HE 0512-3329, both effects contribute significantly to the spectral differences and one cannot be analysed without taking into account the other. For lens modelling purposes, the flux ratios can only be used after correcting for both effects.