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Foreword
(2018)
The rapid digitalization of the Facility Management (FM) sector has increased the demand for mobile, interactive analytics approaches concerning the operational state of a building. These approaches provide the key to increasing stakeholder engagement associated with Operation and Maintenance (O&M) procedures of living and working areas, buildings, and other built environment spaces. We present a generic and fast approach to process and analyze given 3D point clouds of typical indoor office spaces to create corresponding up-to-date approximations of classified segments and object-based 3D models that can be used to analyze, record and highlight changes of spatial configurations. The approach is based on machine-learning methods used to classify the scanned 3D point cloud data using 2D images. This approach can be used to primarily track changes of objects over time for comparison, allowing for routine classification, and presentation of results used for decision making. We specifically focus on classification, segmentation, and reconstruction of multiple different object types in a 3D point-cloud scene. We present our current research and describe the implementation of these technologies as a web-based application using a services-oriented methodology.
Introduction
(2018)
Detecting and recognizing text in natural scene images is a challenging, yet not completely solved task. In recent years several new systems that try to solve at least one of the two sub-tasks (text detection and text recognition) have been proposed. In this paper we present SEE, a step towards semi-supervised neural networks for scene text detection and recognition, that can be optimized end-to-end. Most existing works consist of multiple deep neural networks and several pre-processing steps. In contrast to this, we propose to use a single deep neural network, that learns to detect and recognize text from natural images, in a semi-supervised way. SEE is a network that integrates and jointly learns a spatial transformer network, which can learn to detect text regions in an image, and a text recognition network that takes the identified text regions and recognizes their textual content. We introduce the idea behind our novel approach and show its feasibility, by performing a range of experiments on standard benchmark datasets, where we achieve competitive results.
We propose a new temporal extension of the logic of Here-and-There (HT) and its equilibria obtained by combining it with dynamic logic over (linear) traces. Unlike previous temporal extensions of HT based on linear temporal logic, the dynamic logic features allow us to reason about the composition of actions. For instance, this can be used to exercise fine grained control when planning in robotics, as exemplified by GOLOG. In this paper, we lay the foundations of our approach, and refer to it as Linear Dynamic Equilibrium Logic, or simply DEL. We start by developing the formal framework of DEL and provide relevant characteristic results. Among them, we elaborate upon the relationships to traditional linear dynamic logic and previous temporal extensions of HT.
3D point cloud technology facilitates the automated and highly detailed digital acquisition of real-world environments such as assets, sites, cities, and countries; the acquired 3D point clouds represent an essential category of geodata used in a variety of geoinformation applications and systems. In this paper, we present a web-based system for the interactive and collaborative exploration and inspection of arbitrary large 3D point clouds. Our approach is based on standard WebGL on the client side and is able to render 3D point clouds with billions of points. It uses spatial data structures and level-of-detail representations to manage the 3D point cloud data and to deploy out-of-core and web-based rendering concepts. By providing functionality for both, thin-client and thick-client applications, the system scales for client devices that are vastly different in computing capabilities. Different 3D point-based rendering techniques and post-processing effects are provided to enable task-specific and data-specific filtering and highlighting, e.g., based on per-point surface categories or temporal information. A set of interaction techniques allows users to collaboratively work with the data, e.g., by measuring distances and areas, by annotating, or by selecting and extracting data subsets. Additional value is provided by the system's ability to display additional, context-providing geodata alongside 3D point clouds and to integrate task-specific processing and analysis operations. We have evaluated the presented techniques and the prototype system with different data sets from aerial, mobile, and terrestrial acquisition campaigns with up to 120 billion points to show their practicality and feasibility.
Business processes constantly generate, manipulate, and consume data that are managed by organizational databases. Despite being central to process modeling and execution, the link between processes and data is often handled by developers when the process is implemented, thus leaving the connection unexplored during the conceptual design. In this paper, we introduce, formalize, and evaluate a novel conceptual view that bridges the gap between process and data models, and show some kinds of interesting insights that can be derived from this novel proposal.
We present a prototype of an integrated reasoning environment for educational purposes. The presented tool is a fragment of a proof assistant and automated theorem prover. We describe the existing and planned functionality of the theorem prover and especially the functionality of the educational fragment. This currently supports working with terms of the untyped lambda calculus and addresses both undergraduate students and researchers. We show how the tool can be used to support the students' understanding of functional programming and discuss general problems related to the process of building theorem proving software that aims at supporting both research and education.
Declarative languages for knowledge representation and reasoning provide constructs to define preference relations over the set of possible interpretations, so that preferred models represent optimal solutions of the encoded problem. We introduce the notion of approximation for replacing preference relations with stronger preference relations, that is, relations comparing more pairs of interpretations. Our aim is to accelerate the computation of a non-empty subset of the optimal solutions by means of highly specialized algorithms. We implement our approach in Answer Set Programming (ASP), where problems involving quantitative and qualitative preference relations can be addressed by ASPRIN, implementing a generic optimization algorithm. Unlike this, chains of approximations allow us to reduce several preference relations to the preference relations associated with ASP’s native weak constraints and heuristic directives. In this way, ASPRIN can now take advantage of several highly optimized algorithms implemented by ASP solvers for computing optimal solutions
Manufacturing industries are undergoing a major paradigm shift towards more autonomy. Automated planning and scheduling then becomes a necessity. The Planning and Execution Competition for Logistics Robots in Simulation held at ICAPS is based on this scenario and provides an interesting testbed. However, the posed problem is challenging as also demonstrated by the somewhat weak results in 2017. The domain requires temporal reasoning and dealing with uncertainty. We propose a novel planning system based on Answer Set Programming and the Clingo solver to tackle these problems and incentivize robot cooperation. Our results show a significant performance improvement, both, in terms of lowering computational requirements and better game metrics.
DualPanto
(2018)
We present a new haptic device that enables blind users to continuously track the absolute position of moving objects in spatial virtual environments, as is the case in sports or shooter games. Users interact with DualPanto by operating the me handle with one hand and by holding on to the it handle with the other hand. Each handle is connected to a pantograph haptic input/output device. The key feature is that the two handles are spatially registered with respect to each other. When guiding their avatar through a virtual world using the me handle, spatial registration enables users to track moving objects by having the device guide the output hand. This allows blind players of a 1-on-1 soccer game to race for the ball or evade an opponent; it allows blind players of a shooter game to aim at an opponent and dodge shots. In our user study, blind participants reported very high enjoyment when using the device to play (6.5/7).
Scenograph
(2018)
When developing a real-walking virtual reality experience, designers generally create virtual locations to fit a specific tracking volume. Unfortunately, this prevents the resulting experience from running on a smaller or differently shaped tracking volume. To address this, we present a software system called Scenograph. The core of Scenograph is a tracking volume-independent representation of real-walking experiences. Scenograph instantiates the experience to a tracking volume of given size and shape by splitting the locations into smaller ones while maintaining narrative structure. In our user study, participants' ratings of realism decreased significantly when existing techniques were used to map a 25m2 experience to 9m2 and an L-shaped 8m2 tracking volume. In contrast, ratings did not differ when Scenograph was used to instantiate the experience.
TrussFormer
(2018)
We present TrussFormer, an integrated end-to-end system that allows users to 3D print large-scale kinetic structures, i.e., structures that involve motion and deal with dynamic forces. TrussFormer builds on TrussFab, from which it inherits the ability to create static large-scale truss structures from 3D printed connectors and PET bottles. TrussFormer adds movement to these structures by placing linear actuators into them: either manually, wrapped in reusable components called assets, or by demonstrating the intended movement. TrussFormer verifies that the resulting structure is mechanically sound and will withstand the dynamic forces resulting from the motion. To fabricate the design, TrussFormer generates the underlying hinge system that can be printed on standard desktop 3D printers. We demonstrate TrussFormer with several example objects, including a 6-legged walking robot and a 4m-tall animatronics dinosaur with 5 degrees of freedom.
Low back pain (LBP) is a leading cause of activity limitation. Objective assessment of the spinal motion plays a key role in diagnosis and treatment of LBP. We propose a method that facilitates clinical assessment of lower back motions by means of a wireless inertial sensor network. The sensor units are attached to the right and left side of the lumbar region, the pelvis and the thighs, respectively. Since magnetometers are known to be unreliable in indoor environments, we use only 3D accelerometer and 3D gyroscope readings. Compensation of integration drift in the horizontal plane is achieved by estimating the gyroscope biases from automatically detected initial rest phases. For the estimation of sensor orientations, both a smoothing algorithm and a filtering algorithm are presented. From these orientations, we determine three-dimensional joint angles between the thighs and the pelvis and between the pelvis and the lumbar region. We compare the orientations and joint angles to measurements of an optical motion tracking system that tracks each skin-mounted sensor by means of reflective markers. Eight subjects perform a neutral initial pose, then flexion/extension, lateral flexion, and rotation of the trunk. The root mean square deviation between inertial and optical angles is about one degree for angles in the frontal and sagittal plane and about two degrees for angles in the transverse plane (both values averaged over all trials). We choose five features that characterize the initial pose and the three motions. Interindividual differences of all features are found to be clearly larger than the observed measurement deviations. These results indicate that the proposed inertial sensor-based method is a promising tool for lower back motion assessment.
Beware of SMOMBIES
(2018)
Several research evaluated the user's style of walking for the verification of a claimed identity and showed high authentication accuracies in many settings. In this paper we present a system that successfully verifies a user's identity based on many real world smartphone placements and yet not regarded interactions while walking. Our contribution is the distinction of all considered activities into three distinct subsets and a specific one-class Support Vector Machine per subset. Using sensor data of 30 participants collected in a semi-supervised study approach, we prove that unsupervised verification is possible with very low false-acceptance and false-rejection rates. We furthermore show that these subsets can be distinguished with a high accuracy and demonstrate that this system can be deployed on off-the-shelf smartphones.
In an effort to explain the formation of a narrow third radiation belt at ultra-relativistic energies detected during a solar storm in September 20121, Mann et al.2 present simulations from which they conclude it arises from a process of outward radial diffusion alone, without the need for additional loss processes from higher frequency waves. The comparison of observations with the model in Figs 2 and 3 of their Article clearly shows that even with strong radial diffusion rates, the model predicts a third belt near L* = 3 that is twice as wide as observed and approximately an order of magnitude more intense. We therefore disagree with their interpretation that “the agreement between the absolute fluxes from the model and those observed by REPT [the Relativistic Electron Proton Telescope] shown on Figs 2 and 3 is excellent.”
Previous studies3 have shown that outward radial diffusion plays a very important role in the dynamics of the outer belt and is capable of explaining rapid reductions in the electron flux. It has also been shown that it can produce remnant belts (Fig. 2 of a long-term simulation study4). However, radial diffusion alone cannot explain the formation of the narrow third belt at multi-MeV during September 2012. An additional loss mechanism is required.
Higher radial diffusion rates cannot improve the comparison of model presented by Mann et al. with observations. A further increase in the radial diffusion rates (reported in Fig. 4 of the Supplementary Information of ref. 2) results in the overestimation of the outer belt fluxes by up to three orders of magnitude at energy of 3.4 MeV.
Observations at 2 MeV, where belts show only a two-zone structure, were not presented by Mann et al. Moreover, simulations of electrons with energies below 2 MeV with the same diffusion rates and boundary conditions used by the authors would probably produce very strong depletions down to L = 3–3.5, where L is radial distance from the centre of the Earth to the given field line in the equatorial plane. Observations do not show a non-adiabatic loss below L ∼ 4.5 for 2 MeV. Such different dynamics between 2 MeV and above 4 MeV at around L = 3.5 are another indication that particles are scattered by electromagnetic ion cyclotron (EMIC) waves that affect only energies above a certain threshold.
Observations of the phase space density (PSD) provide additional evidence for the local loss of electrons. Around L* = 3.5–4 PSD shows significant decrease by an order of magnitude starting in the afternoon of 3 September (Fig. 1a), while PSD above L* = 4 is increasing. The minimum in PSD between L* = 3.5–4 continues to decrease until 4 September. This evolution demonstrates that the loss is not produced by outward diffusion. Radial diffusion cannot produce deepening minima, as it works to smooth gradients. Just as growing peaks in PSD show the presence of localized acceleration5, deepening minima show the presence of localized loss.
Figure 1: Time evolution of radiation profiles in electron PSD at relativistic and ultra-relativistic energies.
figure 1
a, Similar to Supplementary Fig. 3 of ref. 2, but using TS07D model10 and for μ = 2,500 MeV G−1, K = 0.05 RE G0.5 (where RE is the radius of the Earth). b, Similar to Supplementary Fig. 3 of ref. 2, but using TS07D model and for μ = 700 MeV G−1, corresponding to MeV energies in the heart of the belt. Minimum in PSD in the heart of the multi-MeV electron radiation belt between 3.5 and 4 RE deepening between the afternoon of 3 September and 5 September clearly show that the narrow remnant belt at multi-MeV below 3.5 RE is produced by the local loss.
Full size image
The minimum in the outer boundary is reached on the evening of 2 September. After that, the outer boundary moves up, while the minimum decreases by approximately an order of magnitude, clearly showing that this main decrease cannot be explained by outward diffusion, and requires additional loss processes. The analysis of profiles of PSD is a standard tool used, for example, in the study about electron acceleration5 and routinely used by the entire Van Allen Probes team. In the Supplementary Information, we show that this analysis is validated by using different magnetic field models. The Supplementary Information also shows that measurements are above background noise.
Deepening minima at multi-MeV during the times when the boundary flux increases are clearly seen in Fig. 1a. They show that there must be localized loss, as radial diffusion cannot produce a minimum that becomes lower with time. At lower energies of 1–2 MeV, which corresponds to lower values of the first adiabatic invariant μ (Fig. 1b), the profiles are monotonic between L* = 3–3.5, consistent with the absence of scattering by EMIC waves that affect only electrons above a certain energy threshold6,7,8,9.
In summary, the results of the modelling and observations presented by Mann et al. do not lend support to the claim of explaining the dynamics of the ultra-relativistic third Van Allen radiation belt in terms of an outward radial diffusion process alone. While the outward radial diffusion driven by the loss to the magnetopause2 is certainly operating during this storm, there is compelling observational and modelling2,6 evidence that shows that very efficient localized electron loss operates during this storm at multi-MeV energies, consistent with localized loss produced by EMIC waves.
The Amyloid-precursor-like protein 1 (APLP1) is a neuronal type I transmembrane protein which plays a role in synaptic adhesion and synaptogenesis. Past investigations indicated that APLP1 is involved in the formation of protein-protein complexes that bridge the junctions between neighboring cells. Nevertheless, APLP1-APLP1 trans interactions have never been directly observed in higher eukaryotic cells. Here, we investigate APLP1 interactions and dynamics directly in living human embryonic kidney (HEK) cells, using fluorescence fluctuation spectroscopy techniques, namely cross-correlation scanning fluorescence correlation spectroscopy (sFCS) and Number&Brightness (N&B). Our results show that APLP1 forms homotypic trans complexes at cell-cell contacts. In the presence of zinc ions, the protein forms macroscopic clusters, exhibiting an even higher degree of trans binding and strongly reduced dynamics. Further evidence from Giant Plasma Membrane Vesicles and live cell actin staining suggests that the presence of an intact cortical cytoskeleton is required for zinc-induced cis multimerization. Subsequently, large adhesion platforms bridging interacting cells are formed through APLP1-APLP1 direct trans interactions. Taken together, our results provide direct evidence that APLP1 functions as a neuronal zinc-dependent adhesion protein and provide a more detailed understanding of the molecular mechanisms driving the formation of APLP1 adhesion platforms. Further, they show that fluorescence fluctuation spectroscopy techniques are useful tools for the investigation of protein-protein interactions at cell-cell adhesion sites.
Background: Pavlovian processes are thought to play an important role in the development, maintenance and relapse of alcohol dependence, possibly by influencing and usurping on- going thought and behavior. The influence of Pavlovian stimuli on on-going behavior is paradigmatically measured by Pavlovian-to-instrumental-transfer (PIT) tasks. These involve multiple stages and are complex. Whether increased PIT is involved in human alcohol
dependence is uncertain. We therefore aimed to establish and validate a modified PIT paradigm that would be robust, consistent, and tolerated by healthy controls as well as by patients suffering from alcohol dependence, and to explore whether alcohol dependence is associated with enhanced Pavlovian-Instrumental transfer.
Methods: 32 recently detoxified alcohol-dependent patients and 32 age and gender matched healthy controls performed a PIT task with instrumental go/no-go approach behaviours. The task involved both Pavlovian stimuli associated with monetary rewards and losses, and images of drinks.
Results: Both patients and healthy controls showed a robust and temporally stable PIT effect. Strengths of PIT effects to drug-related and monetary conditioned stimuli were highly correlated. Patients more frequently showed a PIT effect and the effect was stronger in response to aversively conditioned CSs (conditioned suppression), but there was no group difference in response to appetitive CSs.
Conclusion: The implementation of PIT has favorably robust properties in chronic alcohol- dependent patients and in healthy controls. It shows internal consistency between monetary and drug-related cues. The findings support an association of alcohol dependence with an increased propensity towards PIT.
Pace-of-life syndromes
(2018)
This introduction to the topical collection on Pace-of-life syndromes: a framework for the adaptive integration of behaviour, physiology, and life history provides an overview of conceptual, theoretical, methodological, and empirical progress in research on pace-of-life syndromes (POLSs) over the last decade. The topical collection has two main goals. First, we briefly describe the history of POLS research and provide a refined definition of POLS that is applicable to various key levels of variation (genetic, individual, population, species). Second, we summarise the main lessons learned from current POLS research included in this topical collection. Based on an assessment of the current state of the theoretical foundations and the empirical support of the POLS hypothesis, we propose (i) conceptual refinements of theory, particularly with respect to the role of ecology in the evolution of (sexual dimorphism in) POLS, and (ii) methodological and statistical approaches to the study of POLS at all major levels of variation. This topical collection further holds (iii) key empirical examples demonstrating how POLS structures may be studied in wild populations of (non) human animals, and (iv) a modelling paper predicting POLS under various ecological conditions. Future POLS research will profit from the development of more explicit theoretical models and stringent empirical tests of model assumptions and predictions, increased focus on how ecology shapes (sex-specific) POLS structures at multiple hierarchical levels, and the usage of appropriate statistical tests and study designs. Significance statement As an introduction to the topical collection, we summarise current conceptual, theoretical, methodological and empirical progress in research on pace-of-life syndromes (POLSs), a framework for the adaptive integration of behaviour, physiology and life history at multiple hierarchical levels of variation (genetic, individual, population, species). Mixed empirical support of POLSs, particularly at the within-species level, calls for an evaluation and refinement of the hypothesis. We provide a refined definition of POLSs facilitating testable predictions. Future research on POLSs will profit from the development of more explicit theoretical models and stringent empirical tests of model assumptions and predictions, increased focus on how ecology shapes (sex-specific) POLSs structures at multiple hierarchical levels and the usage of appropriate statistical tests and study designs.
Participants of the 2017 European Space Weather Week in Ostend, Belgium, discussed the stakeholder requirements for space weather-related models. It was emphasized that stakeholders show an increased interest in space weather-related models. Participants of the meeting discussed particular prediction indicators that can provide first-order estimates of the impact of space weather on engineering systems.
Introduction
(2018)
The present thematic set of studies comprises five concise review articles on the use of priming paradigms in different areas of bilingualism research. Their aim is to provide readers with a quick overview of how priming paradigms can be employed in particular subfields of bilingualism research and to make readers aware of the methodological issues that need to be considered when using priming techniques.
I can see it in your face
(2018)
Kim et al. recently measured the structure factor of deeply supercooled water droplets (Reports, 22 December 2017, p. 1589). We raise several concerns about their data analysis and interpretation. In our opinion, the reported data do not lead to clear conclusions about the origins of water’s anomalies.
Skeletal muscle alterations during aging lead to dysfunctional metabolism, correlating with frailty and early mortality. The loss of proteostasis is a hallmark of aging. Whether proteostasis loss plays a role in muscle aging remains elusive. To address this question we collected muscles, Soleus (SOL, type I) and Extensor digitorum longus (EDL, type II), from young (4 months) and old (25 months) C57BL/6 mice and evaluated the proteasomal system. Initial work showed decreased 26 S activity in old SOL. EDL displayed lower proteasomal activity in both ages compared to any of the SOL ages. Moreover, in order to understand if during aging there is the so-called “fiber switch from fast-to-slow”, we performed western blots against sMHC and fMHC (slow and fast myosin heavy chain, respectively). Preliminary results suggest that young SOL is composed by slow twitch fibers but also contains fast twitch fibers, while young EDL seems to be mostly composed by fast twitch fibers that level down during aging, suggesting the switch. As a conclusion, EDL seems to have less proteasomal activity, however, if this is a contributor or a consequence to the muscle fiber switch during aging still needs further investigation.
An essential, respected, and critical aspect of the modern practice of science and scientific publishing is peer review. The process of peer review facilitates best practices in scientific conduct and communication, ensuring that manuscripts published as accurate, valuable, and clearly communicated. The over 152 papers published in Tectonics in 2017 benefit from the time, effort, and expertise of our reviewers who have provided thoughtfully considered advice on each manuscript. This role is critical to advancing our understanding of the evolution of the continents and their margins, as these reviews lead to even clearer and higher-quality papers. In 2017, the over 423 papers submitted to Tectonics were the beneficiaries of more than 786 reviews provided by 562 members of the tectonics community and related disciplines. To everyone who has volunteered their time and intellect to peer reviewing, thank you for helping Tectonics and all other AGU Publications provide the best science possible.
Impact of self-assessment of return to work on employable discharge from multi-component cardiac rehabilitation. Retrospective unicentric analysis of routine data from cardiac rehabilitation in patients below 65 years of age. Presentation in the "Cardiovascular rehabilitation revisited" high impact abstract session during ESC Congress 2018.
Editorial: Reaching to Grasp Cognition: Analyzing Motor Behavior to Investigate Social Interactions
(2018)
We describe how inversion symmetry separation of electronic state manifolds in resonant inelastic soft X-ray scattering (RIXS) can be applied to probe excited-state dynamics with compelling selectivity. In a case study of Fe L3-edge RIXS in the ferricyanide complex Fe(CN)63−, we demonstrate with multi-configurational restricted active space spectrum simulations how the information content of RIXS spectral fingerprints can be used to unambiguously separate species of different electronic configurations, spin multiplicities, and structures, with possible involvement in the decay dynamics of photo-excited ligand-to-metal charge-transfer. Specifically, we propose that this could be applied to confirm or reject the presence of a hitherto elusive transient Quartet species. Thus, RIXS offers a particular possibility to settle a recent controversy regarding the decay pathway, and we expect the technique to be similarly applicable in other model systems of photo-induced dynamics.
Stable covalently photo-cross-linked porous poly(ionic liquid) membrane with gradient pore size
(2018)
Porous polyelectrolyte membranes stable in a highly ionic environment are obtained by covalent crosslinking of an imidazolium-based poly(ionic liquid). The crosslinking reaction involves the UV light-induced thiol-ene (click) chemistry, and the phase separation, occurring during the crosslinking step, generates a fully interconnected porous structure in the membrane. The porosity is on the order of the micrometer scale and the membrane shows a gradient of pore size across the membrane cross-section. The membrane can separate polystyrene latex particles of different size and undergoes actuation in contact with acetone due to the asymmetric porous structure.
Riback et al. (Reports, 13 October 2017, p. 238) used small-angle x-ray scattering (SAXS) experiments to infer a degree of compaction for unfolded proteins in water versus chemical denaturant that is highly consistent with the results from Forster resonance energy transfer (FRET) experiments. There is thus no "contradiction" between the two methods, nor evidence to support their claim that commonly used FRET fluorophores cause protein compaction.
One-tube osmotic fragility (OF) test is a rapid test used widely for screening thalassemia in countries with limited resources. The test has important limitation in that its accuracy relies on observers’ experience.
The iCheck Turbidity is a prototype of portable nephelometer developed by BioAnalyt (Bioanalyt GmbH, Germany). In this study, we assessed the applicability of the iCheck Turbidity, for checking turbidity of the OF-test
Capsella
(2018)
One paragraph of the manuscript of the paper has been inadvertently omitted in the very final stage of its compilation due to a technical mistake. Since this paragraph discusses the declustering of the used earthquake catalogue and is therefore necessary for the understanding of the seismicity data preprocessing, the authors decided to provide this paragraph in form of a correction. The respective paragraph belongs to chapter 2 of the paper, where it was placed originally, and should be inserted into the published paper before the second to the last paragraph. The omitted text reads as follows:
The plant pathogen Pseudomonas syringae is a gram-negative bacterium which infects a wide range of plant species including important crops plants. To suppress plant immunity and cause disease P.syringae injects type-III effector proteins (T3Es) into the plant cell cytosol. In this study, we identified a novel target of the well characterized bacterial T3E HopZ1a. HopZ1a is an acetyltransferase that was shown to disrupt vesicle transport during innate immunity by acetylating tubulin. Using a yeast-two-hybrid screen approach, we identified a REMORIN (REM) protein from tobacco as a novel HopZ1a target. HopZ1a interacts with REM at the plasma membrane (PM) as shown by split-YFP experiments. Interestingly, we found that PBS1, a well-known kinase involved in plant immunity also interacts with REM in pull-down assays, and at the PM as shown by BiFC. Furthermore, we confirmed that REM is phosphorylated by PBS1 in vitro. Overexpression of REM provokes the upregulation of defense genes and leads to disease-like phenotypes pointing to a role of REM in plant immune signaling. Further protein-protein interaction studies reveal novel REM binding partners with a possible role in plant immune signaling. Thus, REM might act as an assembly hub for an immune signaling complex targeted by HopZ1a. Taken together, this is the first report describing that a REM protein is targeted by a bacterial effector. How HopZ1a might mechanistically manipulate the plant immune system through interfering with REM function will be discussed.
Oxidative posttranslationale Modifikationen endogener Proteine werden v. a. durch reaktive Sauerstoff- und Stickstoffspezies (engl:. Reactive Oxygen Species, ROS, reactive nitrogen species, RNS) hervorgerufen und können sowohl reversibel (z. B. Disulfidbindungen) als auch irreversibel (z. B. Proteincarbonyle) erfolgen [1–3]. Lange wurde angenommen, dass oxidative posttranslationale Proteinmodifikationen (oxPTPM) nur von untergeordneter Bedeutung für den Metabolismus sind. Tatsächlich handelt es sich jedoch um einen physiologischen Prozess, der über die Modulation der Proteinstruktur auch die Proteinfunktion (z. B. Enzymaktivität, Stabilität) und somit zahlreiche Stoffwechselwege wie den Energiestoffwechsel, die Immunfunktion, die vaskuläre Funktion sowie Apoptose und Genexpression beeinflussen kann. Die Bildung von oxPTPM ist dabei hochreguliert und hängt u. a. von der Proteinstruktur, der Verfügbarkeit von ROS und RNS sowie dem lokalen Mikromilieu der Zelle ab [2, 4].
Background:
The overall goal of the project ‘StiEL’ is to contribute to the professional development of teachers and other educational staff working at German secondary schools. The aim is to develop an evidence-based training concept for the inclusion of students with diverse abilities. The project is organized as a collaborative research effort of three partnering institutions and funded by the German Federal Ministry of Education and Research from 2018-2021.
Methods:
To support the on-going transition towards inclusive school practices, a multi-stage approach is envisaged. The first phase aims at a scoping review of existing literature and programmes on inclusion. The overview is supplemented by interviews with school staff members. Training modules are developed in the second project phase. The third phase of StiEL puts the newly developed training program into practice. The knowledge and skills acquired by the participants through the training as well as the teaching and management of inclusive classrooms after the training are evaluated through longitudinal and ethnographic approaches. The final project phase creates a best practice manual and makes the modules available via open access databases.
Results:
The presentation will focus on the first phase and try to explore the health-related consequences of the transition towards an inclusive school system in Germany for different participants. We will present preliminary results of expert interviews as well as some results from the literature screening. Due to our findings the current practice on German schools towards the road to inclusion is very stressful for all participants. We will explore recommendations for health promoting schools under conditions of inclusion.
Conclusions:
In terms of health-related consequences for all participants, the road to inclusion is very ambitious but also very stressful. Regarding the development of an inclusive school system, we need to focus much more on health and health promotion.
The centrosome is not only the largest and most sophisticated protein complex within a eukaryotic cell, in the light of evolution, it is also one of its most ancient organelles. This special issue of "Cells" features representatives of three main, structurally divergent centrosome types, i.e., centriole-containing centrosomes, yeast spindle pole bodies (SPBs), and amoebozoan nucleus-associated bodies (NABs). Here, I discuss their evolution and their key-functions in microtubule organization, mitosis, and cytokinesis. Furthermore, I provide a brief history of centrosome research and highlight recently emerged topics, such as the role of centrioles in ciliogenesis, the relationship of centrosomes and centriolar satellites, the integration of centrosomal structures into the nuclear envelope and the involvement of centrosomal components in non-centrosomal microtubule organization.
A balance to death
(2018)
Leaf senescence plays a crucial role in nutrient recovery in late-stage plant development and requires vast transcriptional reprogramming by transcription factors such as ORESARA1 (ORE1). A proteolytic mechanism is now found to control ORE1 degradation, and thus senescence, during nitrogen starvation.
Screeninginstrumente
(2018)
This study examined the relationships between the three phenotypic domains of the triarchic model of psychopathy —boldness, meanness, disinhibition— and electrophysiological indices of inhibitory control (NoGo-N2/NoGo-P3). EEG data from a 256-channel dense array were recorded while participants (135 un-dergraduates assessed via the Triarchic Psychopathy Measure) performed a Go/NoGo task with three types of stimuli (60% frequent-Go, 20% infrequent-Go, 20% infrequent-NoGo). N2 was defined as the mean amplitude between 240 ms and 340 ms after stimuli onset over fronto-central sensors on correct trials; P300 was defined as the mean amplitude between 350 ms and 550 ms after stimuli onset over centro-parietal sensors on correct trials. Multiple regression analyses using gender-corrected triarchic scores as predictors revealed that only Disinhibition scores significantly predicted reduced NoGo-N2 amplitudes (3.5% explained variance, beta weight = .23, p < .05) and reduced P3 amplitudes for NoGo and infrequent-Go trials (3.1 and 3.2% explained variance, respectively, beta weights = -.21, ps < .05). Our results indicate that high disinhibition entails deviations in early conflict monitoring processes (reduced NoGo-N2), as well as in latter evaluative and updating processing stages of infrequent events (reduced NoGo-P3 and infrequent-Go-P3). The null contribution of meanness and boldness domains in these results suggests that N2 and P3 amplitudes in Go/NoGo tasks could be considered as neurobiological indices of the externalizing tendencies comprised in this personality disorder.
Editorial
(2018)
"Never doubt that a small group of thoughtful, committed citizens can change the world; indeed, it's the only thing that ever has. - Margaret Mead."
With the last issue of this year we want to point out directions towards what will come and what challenges and opportunities lie ahead of us. More needed than ever are joint creative efforts to find ways to collaborate and innovate in order to secure the wellbeing of our earth for the next generation to come. We have found ourselves puzzled that we could assemble a sustainability issue without having a call for papers or a special issue. In fact, many of the submissions we currently receive, deal with sustainable, ecological or novel approaches to management and organizations. As creativity and innovation are undisputable necessary ingredients for reaching the sustainable development goals, empirical proof and research in this area are still in their infancy. While the role of design and design thinking has been highlighted before for solving wicked societal problems, a lot more research is needed which creative and innovative ways organisations and societies can take to find solutions to climate change, poverty, hunger and education. We would therefore like to call to you, our readers and writers to tackle these problems with your research.
The first article in this issue addresses one of the above named challenges - the role of innovation for achieving the transition to a low-carbon energy world. In “Innovating for low-carbon energy through hydropower: Enabling a conservation charity's transition to a low-carbon community”, the authors John Gallagher, Paul Coughlan, A. Prysor Williams and Aonghus McNabola look at how an eco-design approach has supported a community transition to low-carbon. They highlight the importance of effective management as well as external collaboration and how the key for success lay in fostering an open environment for creativity and idea sharing. The second article addresses another of the grand challenges, the future of mobility and uses a design-driven approach to develop scenarios for mobility in cities. In “Designing radical innovations of meanings for society: envisioning new scenarios for smart mobility”, the authors Claudio Dell'Era, Naiara Altuna and Roberto Verganti investigate how new meanings can be designed and proposed to society rather than to individuals in the particular context of smart mobility. Through two case studies the authors argue for a multi-level perspective, taking the perspective of the society to solve societal challenges while considering the needs of the individual. The latter is needed because we will not change if our needs are not addressed. Furthermore, the authors find that both, meaning and technology need to be considered to create radical innovation for society. The role of meaning continues in the third article in this issue. The authors Marta Gasparin and William Green show in their article “Reconstructing meaning without redesigning products: The case of the Serie7 chair” how meaning changes over time even though the product remains the same. Through an in-depth retrospective study of the Serie 7 chair the authors investigate the relationship between meaning and the materiality of the object, and show the importance of materiality in constructing product meaning over long periods. Translating this meaning over the course of the innovation process is an important task of management in order to gain buy-in from all involved stakeholders. In the following article “A systematic approach for new technology development by using a biomimicry-based TRIZ contradiction matrix” the authors Byungun Yoon, Chaeguk Lim, Inchae Park and Dooseob Yoon develop a systematic process combining biomimicry and technology-based TRIZ in order to solve technological problems or develop new technologies based on completely new sources or combinations from technology and biology.
In the fifth article in this issue “Innovating via Building Absorptive Capacity: Interactive Effects of Top Management Support of Learning, Employee Learning Orientation, and Decentralization Structure” the authors Li-Yun Sun, Chenwei Li and Yuntao Dong examine the effect of learning-related personal and contextual factors on organizational absorptive capability and subsequent innovative performance. The authors find positive effects as well as a moderation influence of decentralized organizational decision-making structures. In the sixth article “Creativity within boundaries: social identity and the development of new ideas in franchise systems” the authors Fanny Simon, Catherine Allix-Desfautaux, Nabil Khelil and Anne-Laure Le Nadant address the paradox of balancing novelty and conformity for creativity in a franchise system. This research is one of the first we know to explicitly address creativity and innovation in such a rigid and pre-determined system. Using a social identity perspective, they can show that social control, which may be exerted by manipulating group identity, is an efficient lever to increase both the creation and the diffusion of the idea. Furthermore, they show that franchisees who do not conform to the norm of the group are stigmatized and must face pressure from the group to adapt their behaviors. This has important implications for future research. In the following article “Exploring employee interactions and quality of contributions in intra-organisational innovation platforms” the authors Dimitra Chasanidou, Njål Sivertstol and Jarle Hildrum examine the user interactions in an intra-organisational innovation platform, and also address the influence of user interactions for idea development. The authors find that employees communicate through the innovation platform with different interaction, contribution and collaboration types and propose three types of contribution qualities—passive, efficient and balanced contribution. In the eighth article “Ready for Take-off”: How Open Innovation influences startup success” Cristina Marullo, Elena Casprini, Alberto di Minin and Andrea Piccaluga seek to predict new venture success based on factors that can be observed in the pre-startup phase. The authors introduce different variables of founding teams and how these relate to startup success. Building on large-scale dataset of submitted business plans at UC Berkeley, they can show that teams with high skills diversity and past joint experience are a lot better able to prevent the risk of business failure at entry and to adapt the internal resources to market conditions. Furthermore, it is crucial for the team to integrate many external knowledge sources into their process (openness) in order to be successful. The crucial role of knowledge and how it is communicated and shared is the focal point of Natalya Sergeeva's and Anna Trifilova's article on “The role of storytelling in the innovation process”. They authors can show how storytelling has an important role to play when it comes to motivating employees to innovate and promoting innovation success stories inside and outside the organization. The deep human desire to hear and experience stories is also addressed in the last article in this issue “Gamification Approaches to the Early Stage of Innovation” by Rui Patricio, Antonio Moreira and Francesco Zurlo. Using gamification approaches at the early stage of innovation promises to create better team coherence, let employees experience fun and engagement, improve communication and foster knowledge exchange. Using an analytical framework, the authors analyze 15 articles that have looked at gamification in the context of innovation management before. They find that gamification indeed supports firms in becoming better at performing complex innovation tasks and managing innovation challenges. Furthermore, gamification in innovation creates a space for inspiration, improves creativity and the generation of high potential ideas.
We study the rupture processes of Iquique earthquake 8.1 (2014/04/01) and its largest aftershock 7.7 (2014/04/03) that ruptured the North Chile subduction zone. High-rate Global Positioning System (GPS) recordings and strong motion data are used to reconstruct the evolution of the slip amplitude, rise time and rupture time of both earthquakes. A two-step inversion scheme is assumed, by first building prior models for both earthquakes from the inversion of the estimated static displacements and then, kinematic inversions in the frequency domain are carried out taken into account this prior information. The preferred model for the mainshock exhibits a seismic moment of 1.73 × 1021 Nm ( 8.1) and maximum slip of ∼9 m, while the aftershock model has a seismic moment of 3.88 × 1020 ( 7.7) and a maximum slip of ∼3 m. For both earthquakes, the final slip distributions show two asperities (a shallow one and a deep one) separated by an area with significant slip deficit. This suggests a segmentation along-dip which might be related to a change of the dipping angle of the subducting slab inferred from gravimetric data. Along-strike, the areas where the seismic ruptures stopped seem to be well correlated with geological features observed from geophysical information (high-resolution bathymetry, gravimetry and coupling maps) that are representative of the long-term segmentation of the subduction margin. Considering the spatially limited portions that were broken by these two earthquakes, our results support the idea that the seismic gap is not filled yet.
Der Jüdische Kalender für das Jahr 5779 des Judaica-Portal Berlin-Brandenburg stellt jede der beteiligten Bibliothek auf einem Kalenderblatt vor. Auf der Vorderseite befindet sich jeweils ein doppeltes Kalendarium: Die Kalenderblätter folgen dem christlichen Jahr, parallel dazu sind die entsprechenden jüdischen Monatsangaben angegeben. Jüdische Feiertage werden durch hervorgehobene Zahlen im Kalendarium angezeigt. Auf der Rückseite finden sich diese Feiertage aufgelistet, ebenso wie die jüdischen Monatsnamen in lateinischer Schrift.
Zudem befindet sich auf der Vorderseite jeweils ein repräsentatives Bild der Bibliothek, mit dem daneben befindlichen QR-Code gelangt man direkt zum jeweiligen Bucheintrag im Judiaca-Portal. Auf der Rückseite gibt es eine kurze Bildbeschreibung zum abgedruckten Bild.
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Grußwort
(2018)
Clause typing in Germanic
(2018)
The questionnaire investigates the functional left periphery of various finite clauses in Germanic languages, with particular attention paid to clause-typing elements and the combinations thereof. The questionnaire is mostly concerned with clause typing in embedded clauses, but main clause counterparts are also considered for comparative purposes. The chief aim was to achieve comparable results across Germanic languages, though the standardised questionnaire may also be helpful in the study of other languages, too. Most questions examine the availability of various complementisers and clause-typing operators, and in some cases the movement of verbs to the left periphery is also taken into account. The questionnaire is split into seven major parts according to the types of clauses under scrutiny.
All instructions were given in English and the individual questions either concern translations of given sentences from English into the target language, and/or they ask for specific details about the constructions in the target language.
The present document contains the questionnaire itself (together with the instructions given at the beginning of the questionnaire and at the beginning of the individual sections, as well as the questions asking for personal data), the sociolinguistic data of the speakers, and the actual results for the individual languages. Five Germanic languages are included: Dutch, Danish, Icelandic, Norwegian and Swedish. For each language, two informants were recruited. Given the small number of informants, the present study serves as a qualitative investigation and as a basis for further, quantitative and experimental studies.