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nempe exemplis discimus
(2018)
‘Tradition’ and ‘example’ are key concepts of the ancient fable. The fable has not only developed a literary tradition of its own, but from the beginning, it was also used as a rhetorical device, the exemplum. A diachronic overview of the genre and especially the use of the fable as exemplum reveals that Phaedrus adapts these terms in a new and ingenious way. In a case study of fable 3.9 this paper demonstrates how the fable finds its place in the literary tradition of the motif, how Socrates is presented as a model for the poet’s persona and how an intricate network of inter- and intratextual references is established between Socrates, Aesop, Phaedrus, and his potential successors. The subtle irony of the poet is particularly evident in the gradual development of the poet’s persona into a caricature, but the message of the fable itself remains unaffected: the value of true friendship.
Genetic and environmental factors both contribute to cognitive test performance. A substantial increase in average intelligence test results in the second half of the previous century within one generation is unlikely to be explained by genetic changes. One possible explanation for the strong malleability of cognitive performance measure is that environmental factors modify gene expression via epigenetic mechanisms. Epigenetic factors may help to understand the recent observations of an association between dopamine-dependent encoding of reward prediction errors and cognitive capacity, which was modulated by adverse life events. The possible manifestation of malleable biomarkers contributing to variance in cognitive test performance, and thus possibly contributing to the "missing heritability" between estimates from twin studies and variance explained by genetic markers, is still unclear. Here we show in 1475 healthy adolescents from the IMaging and GENetics (IMAGEN) sample that general IQ (gIQ) is associated with (1) polygenic scores for intelligence, (2) epigenetic modification of DRD2 gene, (3) gray matter density in striatum, and (4) functional striatal activation elicited by temporarily surprising reward-predicting cues. Comparing the relative importance for the prediction of gIQ in an overlapping subsample, our results demonstrate neurobiological correlates of the malleability of gIQ and point to equal importance of genetic variance, epigenetic modification of DRD2 receptor gene, as well as functional striatal activation, known to influence dopamine neurotransmission. Peripheral epigenetic markers are in need of confirmation in the central nervous system and should be tested in longitudinal settings specifically assessing individual and environmental factors that modify epigenetic structure.