Refine
Year of publication
- 2019 (2591) (remove)
Document Type
- Article (1679)
- Doctoral Thesis (257)
- Postprint (211)
- Other (166)
- Monograph/Edited Volume (81)
- Review (68)
- Working Paper (36)
- Part of a Book (28)
- Part of Periodical (21)
- Master's Thesis (12)
Language
Keywords
- morphology (34)
- linguistics (31)
- syntax (31)
- Informationsstruktur (30)
- Morphologie (30)
- information structure (30)
- Festschrift (29)
- Linguistik (29)
- Syntax (29)
- festschrift (29)
Institute
- Institut für Biochemie und Biologie (352)
- Institut für Physik und Astronomie (312)
- Institut für Geowissenschaften (276)
- Institut für Chemie (183)
- Department Psychologie (110)
- Institut für Ernährungswissenschaft (89)
- Department Linguistik (86)
- Institut für Umweltwissenschaften und Geographie (80)
- Wirtschaftswissenschaften (73)
- Hasso-Plattner-Institut für Digital Engineering GmbH (69)
Obligate human pathogenic Neisseria gonorrhoeae are the second most frequent bacterial cause of sexually transmitted diseases. These bacteria invade different mucosal tissues and occasionally disseminate into the bloodstream. Invasion into epithelial cells requires the activation of host cell receptors by the formation of ceramide-rich platforms. Here, we investigated the role of sphingosine in the invasion and intracellular survival of gonococci. Sphingosine exhibited an anti-gonococcal activity in vitro. We used specific sphingosine analogs and click chemistry to visualize sphingosine in infected cells. Sphingosine localized to the membrane of intracellular gonococci. Inhibitor studies and the application of a sphingosine derivative indicated that increased sphingosine levels reduced the intracellular survival of gonococci. We demonstrate here, that sphingosine can target intracellular bacteria and may therefore exert a direct bactericidal effect inside cells.
Schwert der Justiz
(2019)
Das Gerichtsvollzieherwesen erlebte in den zurückliegenden 200 Jahren eine wechselhafte Entwicklung. Die Gerichtsvollzieher standen und stehen seit jeher zwischen verschiedenen Polen: zwischen Selbstständigkeit und Abhängigkeit, zwischen Eigenverantwortung und Weisungsgebundenheit, zwischen moderatem Mittlertum und einem rein exekutiven Verständnis des Amtes als »Schwert der Justiz«.
Die Beiträge dieses Bandes beschreiben die Geschichte des Gerichtsvollzieherwesens von seinen Anfängen im territorial zersplitterten Deutschland um 1800 bis in die heutige Zeit.
Vorwort
(2019)
Fälle zum Zivilprozessrecht
(2019)
The role of perceived need support from exercise professionals in improving mental health was examined in a sample of older adults, thereby validating the short Health Care Climate Questionnaire. A total of 491 older people (M = 72.68 years; SD = 5.47) attending a health exercise program participated in this study. Cronbach's alpha was found to be high (alpha = .90). Satisfaction with the exercise professional correlated moderately with the short Health Care Climate Questionnaire mean value (r = .38; p < .01). The mediator analyses yielded support for the self-determination theory process model in older adults by showing both basic need satisfaction and frustration as mediating variables between perceived autonomy support and depressive symptoms. The short Health Care Climate Questionnaire is an economical instrument for assessing basic need satisfaction provided by the exercise therapist from the participant's perspective. Furthermore, this cross-sectional study supported the link from coaching style to the satisfaction/frustration of basic psychological needs, which in turn, predicted mental health. Analyses of criterion validity suggest a revision of the construct by integrating need frustration.
Many human infants grow up learning more than one language simultaneously but only recently has research started to study early language acquisition in this population more systematically. The paper gives an overview on findings on early language acquisition in bilingual infants during the first two years of life and compares these findings to current knowledge on early language acquisition in monolingual infants. Given the state of the research, the overview focuses on research on phonological and early lexical development in the first two years of life. We will show that the developmental trajectory of early language acquisition in these areas is very similar in mono- and bilingual infants suggesting that these early steps into language are guided by mechanisms that are rather robust against the differences in the conditions of language exposure that mono- and bilingual infants typically experience.
Data assimilation aims to blend incomplete and inaccurate data with physics-based dynamical models. In the Earth's radiation belts, it is used to reconstruct electron phase space density, and it has become an increasingly important tool in validating our current understanding of radiation belt dynamics, identifying new physical processes, and predicting the near-Earth hazardous radiation environment. In this study, we perform reanalysis of the sparse measurements from four spacecraft using the three-dimensional Versatile Electron Radiation Belt diffusion model and a split-operator Kalman filter over a 6-month period from 1 October 2012 to 1 April 2013. In comparison to previous works, our 3-D model accounts for more physical processes, namely, mixed pitch angle-energy diffusion, scattering by Electromagnetic Ion Cyclotron waves, and magnetopause shadowing. We describe how data assimilation, by means of the innovation vector, can be used to account for missing physics in the model. We use this method to identify the radial distances from the Earth and the geomagnetic conditions where our model is inconsistent with the measured phase space density for different values of the invariants mu and K. As a result, the Kalman filter adjusts the predictions in order to match the observations, and we interpret this as evidence of where and when additional source or loss processes are active. The current work demonstrates that 3-D data assimilation provides a comprehensive picture of the radiation belt electrons and is a crucial step toward performing reanalysis using measurements from ongoing and future missions.