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Fossil oyster shells are well-suited to provide palaeotemperature proxies from geologic to seasonal timescales due to their ubiquitous occurrence from Triassic to Quaternary sediments, the seasonal nature of their shell growth and their relative strong resistance to post-mortem alteration. However, the common use to translate calcitic oxygen isotopes into palaeotemperatures is challenged by uncertainties in accounting for past seawater delta O-18, especially in shallow coastal environment where oysters calcify. In principle, the Mg/Ca ratio in oyster shells can provide an alternative palaeothermometer. Several studies provided temperature calibrations for this potential proxy based on modem species, nevertheless their application to palaeo-studies remains hitherto unexplored. Here, we show that past temperature variability in seawater can be obtained from Mg/Ca analyses from selected fossil oyster species and specimens. High-resolution Mg/Ca profiles, combined with delta O-18, were obtained along 41 fossil oyster shells of seven different species from the Palaeogene Proto-Paratethys sea (Central Asia) found in similar as well as different depositional age and environments providing comparison. Suitable Mg/Ca profiles, defined by continuous cyclicity and reproducibility within one shell, are found to be consistent for specimens of the same species but differ systematically between species, implying a dominant species-specific effect on the Mg/Ca signal. Two species studied here (Ostrea (Turkostrea) strictiplicata and Sokolowia buhsii) provide an excellent proxy for palaeoclimate reconstruction from China to Europe in Palaeogene marine sediments. More generally, the protocol developed here can be applied to identify other fossil oyster species suitable for palaeoclimate reconstructions. (C) 2015 Elsevier B.V. All rights reserved.
A link between chemical weathering and physical erosion exists at the catchment scale over a wide range of erosion rates(1,2). However, in mountain environments, where erosion rates are highest, weathering may be kinetically limited(3-5) and therefore decoupled from erosion. In active mountain belts, erosion is driven by bedrock landsliding(6) at rates that depend strongly on the occurrence of extreme rainfall or seismicity(7). Although landslides affect only a small proportion of the landscape, bedrock landsliding can promote the collection and slow percolation of surface runoff in highly fragmented rock debris and create favourable conditions for weathering. Here we show from analysis of surface water chemistry in the Southern Alps of New Zealand that weathering in bedrock landslides controls the variability in solute load of these mountain rivers. We find that systematic patterns in surface water chemistry are strongly associated with landslide occurrence at scales from a single hillslope to an entire mountain belt, and that landslides boost weathering rates and river solute loads over decades. We conclude that landslides couple erosion and weathering in fast-eroding uplands and, thus, mountain weathering is a stochastic process that is sensitive to climatic and tectonic controls on mass wasting processes.
Antarctica’s contribution to global sea-level rise has recently been increasing1. Whether its ice discharge will become unstable and decouple from anthropogenic forcing2,3,4 or increase linearly with the warming of the surrounding ocean is of fundamental importance5. Under unabated greenhouse-gas emissions, ocean models indicate an abrupt intrusion of warm circumpolar deep water into the cavity below West Antarctica’s Filchner–Ronne ice shelf within the next two centuries6,7. The ice basin’s retrograde bed slope would allow for an unstable ice-sheet retreat8, but the buttressing of the large ice shelf and the narrow glacier troughs tend to inhibit such instability9,10,11. It is unclear whether future ice loss will be dominated by ice instability or anthropogenic forcing. Here we show in regional and continental-scale ice-sheet simulations, which are capable of resolving unstable grounding-line retreat, that the sea-level response of the Filchner–Ronne ice basin is not dominated by ice instability and follows the strength of the forcing quasi-linearly. We find that the ice loss reduces after each pulse of projected warm water intrusion. The long-term sea-level contribution is approximately proportional to the total shelf-ice melt. Although the local instabilities might dominate the ice loss for weak oceanic warming12, we find that the upper limit of ice discharge from the region is determined by the forcing and not by the marine ice-sheet instability.
The Puna Plateau, adjacent Eastern Cordillera and the Sierras Pampeanas of the central Andes are largely characterized by thick-skinned, basement-involved deformation. The Puna Plateau hosts similar to N-S trending bedrock ranges bounded by deep-seated reverse faults and sedimentary basins. We contribute to the understanding of thick-skinned dynamics in the Puna Plateau by constraining regional kinematics of the poorly understood southern Puna Plateau through a multidisciplinary approach. On the southeastern plateau, sandstone modal composition and detrital zircon U-Pb and apatite fission-track data from Cenozoic strata indicate basin accumulation during the late Eocene to early Oligocene (similar to 38-28 Ma). Provenance analysis reveals the existence of a regional-scale basin covering the southern Puna Plateau during late Eocene to early Oligocene time (similar to 38-28 Ma) that was sourced from both the western plateau and the eastern plateau margin and had a depocenter located to the west. Petrographic and detrital zircon U-Pb data reveal erosion of proximal western and eastern sources after 12 Ma, in mid-late Miocene time. This indicates that the regional basin was compartmentalized into small-scale depocenters by the growth of basement-cored ranges continuing into the late Miocene (similar to 12-8 Ma). We suggest that the Cenozoic history of the southern Puna Plateau records the formation of a regional basin that was possibly driven by lithospheric flexure during the late Eocene to early Oligocene, before the growth of distributed basement-cored ranges starting as early as the late Oligocene. (C) 2015 Elsevier B.V. All rights reserved.
On the basis of the clinical studies in patients with coronary artery disease (CAD) presenting an increased percentage of activated platelets, we hypothesized that hemocompatibility testing utilizing platelets from healthy individuals may result in an underestimation of the materials' thrombogenicity. Therefore, we investigated the interaction of polymer-based biomaterials with platelets from CAD patients in comparison to platelets from apparently healthy individuals. In vitro static thrombogenicity tests revealed that adherent platelet densities and total platelet covered areas were significantly increased for the low (polydimethylsiloxane, PDMS) and medium (Collagen) thrombogenic surfaces in the CAD group compared to the healthy subjects group. The area per single platelet—indicating the spreading and activation of the platelets—was markedly increased on PDMS treated with PRP from CAD subjects. This could not be observed for collagen or polytetrafluoroethylene (PTFE). For the latter material, platelet adhesion and surface coverage did not differ between the two groups. Irrespective of the substrate, the variability of these parameters was increased for CAD patients compared to healthy subjects. This indicates a higher reactivity of platelets from CAD patients compared to the healthy individuals. Our results revealed, for the first time, that utilizing platelets from apparently healthy donors bears the risk of underestimating the thrombogenicity of polymer-based biomaterials.
New age data have been obtained to time constrain the recent Quaternary volcanism of El Hierro (Canary Islands) and to estimate its recurrence rate. We have carried out Ar-40/Ar-39 geochronology on samples spanning the entire volcanostratigraphic sequence of the island and C-14 geochronology on the most recent eruption on the northeast rift of the island: 2280 +/- 30 yr BP. We combine the new absolute data with a revision of published ages onshore, some of which were identified through geomorphological criteria (relative data). We present a revised and updated chronology of volcanism for the last 33 ka that we use to estimate the maximum eruptive recurrence of the island. The number of events per year determined is 9.7 x 10(-4) for the emerged part of the island, which means that, as a minimum, one eruption has occurred approximately every 1000 years. This highlights the need of more geochronological data to better constrain the eruptive recurrence of El Hierro. (C) 2015 Elsevier Ltd. All rights reserved.
The abandonment of military areas leads to succession processes affecting valuable open-land habitats and is considered to be a major threat for European butterflies. We assessed the ability of hyper spectral remote sensing data to spatially predict the occurrence of one of the most endangered butterfly species (Hipparchia statilinus) in Brandenburg (Germany) on the basis of habitat characteristics at a former military training area. Presence-absence data were sampled on a total area of 36 km(2), and N = 65 adult individuals of Hipparchia statilinus could be detected. The floristic composition within the study area was modeled in a three-dimensional ordination space. Occurrence probabilities for the target species were predicted as niches between ordinated floristic gradients by using Regression Kriging of Indicators. Habitat variance could be explained by up to 81 % with spectral variables at a spatial resolution of 2 x 2 m by transferring PLSR models to imagery. Ordinated ecological niche of Hipparchia statilinus was tested against environmental predictor variables. N = 6 variables could be detected to be significantly correlated with habitat preferences of Hipparchia statilinus. They show that Hipparchia statilinus can serve as a valuable indicator for the evaluation of the conservation status of Natura 2000 habitat type 2330 (inland dunes with open Corynephorus and Agrostis grasslands) protected by the Habitat Directive (Council Directive 92/43/EEC). The authors of this approach, conducted in August 2013 at Doberitzer Heide Germany, aim to increase the value of remote sensing as an important tool for questions of biodiversity research and conservation.
Spatio-temporal control of cellular uptake achieved by photoswitchable cell-penetrating peptides
(2016)
The selective uptake of compounds into specific cells of interest is a major objective in cell biology and drug delivery. By incorporation of a novel, thermostable azobenzene moiety we generated peptides that can be switched optically between an inactive state and an active, cell-penetrating state with excellent spatio-temporal control.
Cross-sectional studies revealed that inclusion of unstable elements in core-strengthening exercises produced increases in trunk muscle activity and thus potential extra stimuli to induce more pronounced performance enhancements in youth athletes. Thus, the purpose of the study was to investigate changes in neuromuscular and athletic performance following core strength training performed on unstable (CSTU) compared with stable surfaces (CSTS) in youth soccer players. Thirty-nine male elite soccer players (age: 17 +/- 1 years) were assigned to two groups performing a progressive core strength-training program for 9 weeks (2-3 times/week) in addition to regular in-season soccer training. CSTS group conducted core exercises on stable (i.e., floor, bench) and CSTU group on unstable (e.g., Thera-Band (R) Stability Trainer, Togu (c) Swiss ball) surfaces. Measurements included tests for assessing trunk muscle strength/activation, countermovement jump height, sprint time, agility time, and kicking performance. Statistical analysis revealed significant main effects of test (pre vs post) for trunk extensor strength (5%, P<0.05, d=0.86), 10-20-m sprint time (3%, P<0.05, d=2.56), and kicking performance (1%, P<0.01, d=1.28). No significant Groupxtest interactions were observed for any variable. In conclusion, trunk muscle strength, sprint, and kicking performance improved following CSTU and CSTS when conducted in combination with regular soccer training.
Acting during phase II metabolism, sulfotransferases (SULTs) serve detoxification by transforming a broad spectrum of compounds from pharmaceutical, nutritional, or environmental sources into more easily excretable metabolites. However, SULT activity has also been shown to promote formation of reactive metabolites that may have genotoxic effects. SULT subtype 1E1 (SULT1E1) was identified as a key player in estrogen homeostasis, which is involved in many physiological processes and the pathogenesis of breast and endometrial cancer. The development of an in silico prediction model for SULT1E1 ligands would therefore support the development of metabolically inert drugs and help to assess health risks related to hormonal imbalances. Here, we report on a novel approach to develop a model that enables prediction of substrates and inhibitors of SULT1E1. Molecular dynamics simulations were performed to investigate enzyme flexibility and sample protein conformations. Pharmacophores were developed that served as a cornerstone of the model, and machine learning techniques were applied for prediction refinement. The prediction model was used to screen the DrugBank (a database of experimental and approved drugs): 28% of the predicted hits were reported in literature as ligands of SULT1E1. From the remaining hits, a selection of nine molecules was subjected to biochemical assay validation and experimental results were in accordance with the in silico prediction of SULT1E1 inhibitors and substrates, thus affirming our prediction hypotheses.