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The body as a wonderland
(2024)
Archive haben die Aufgabe, Wissen zu bewahren und zugänglich zu machen. Die Sammlungen des Museums für Naturkunde Berlin (MfN) wuchsen während der Zeit der europäischen Kolonialexpansion stark an. Naturalien aus der ganzen Welt gelangten nach Berlin und gleichzeitig fand ein wissenschaftlicher Austausch zu denselben statt. Die Spuren dieser Objekte und der Korrespondenzen können im Archiv des Museums nachverfolgt werden. Heute gelten koloniale Kontexte weitestgehend als Unrechtskontexte, deren Aufarbeitung gefordert wird. Um Provenienzforschung betreiben zu können, ist es daher unerlässlich, dass Museen und Archive ihre Sammlungen offenlegen (soweit rechtlich und ethisch möglich) und Außenstehenden den Zugriff ermöglichen.
Im Rahmen dieser Masterarbeit soll der respektvolle Umgang mit Archivgut aus kolonialen Kontexten kritisch reflektiert und Handlungsfelder für einen kulturell angemessenen Umgang mit sensiblen Inhalten aufgezeigt werden. Konkret beziehen sich die Handlungsoptionen auf Archivgut aus kolonialen Kontexten mit Bezug zu Australien. Dabei werden Provenienzforschung, Sensibilität, Mehrsprachigkeit, indigenes kulturelles Wissen (ICIP) sowie Plattform- und Schnittstellenoptionen für die Vernetzung von Daten und Inhalten bedacht. Ziel ist es, vor dem Hintergrund der Archive als Orte kulturellen Gedächtnisses den Umgang mit Archivgut aus kolonialen Kontexten zu reflektieren.
This study aims to bring together scattered research findings on user satisfaction with mobile government apps into a unified framework. The researchers analyzed 70 high-quality papers from leading journals and conferences and systematically integrated different frameworks and case studies to reflect the importance of the field over time while also highlighting methodological and geographical research gaps. The study achieved a significant methodological advance by developing codebooks for empirical analysis utilizing the App Store. This approach validated the framework’s dimensions on 8,524 reviews, demonstrating the framework’s applicability to platform-based apps and identifying critical areas for future research. Combining academic insights with practical findings, this research provides comprehensive guidance for developing and evaluating user-centered mobile government apps, facilitating improved service delivery and alignment with user expectations.
Despite faster-than-expected progress in clean energy technology deployment, global annual CO2 emissions have increased from 2020 to 2023. The feasibility of limiting warming to 1.5 °C is therefore questioned. Here we present a model intercomparison study that accounts for emissions trends until 2023 and compares cost-effective scenarios to alternative scenarios with institutional, geophysical and technological feasibility constraints and enablers informed by previous literature. Our results show that the most ambitious mitigation trajectories with updated climate information still manage to limit peak warming to below 1.6 °C (‘low overshoot’) with around 50% likelihood. However, feasibility constraints, especially in the institutional dimension, decrease this maximum likelihood considerably to 5–45%. Accelerated energy demand transformation can reduce costs for staying below 2 °C but have only a limited impact on further increasing the likelihood of limiting warming to 1.6 °C. Our study helps to establish a new benchmark of mitigation scenarios that goes beyond the dominant cost-effective scenario design.
Die bedarfsgerechte Versorgung im Alter zukünftig sicherzustellen, gehört zu den entscheidenden Aufgaben unserer Zeit. Der in Deutschland bestehende Fachkräftemangel sowie der demografische Wandel belasten das Pflegesystem in mehrfacher Hinsicht: In einer alternden Gesellschaft sind immer mehr Menschen auf eine anhaltende Unterstützung angewiesen. Niedrige Geburtenraten und damit verbunden ein sinkender Bevölkerungs-anteil von Menschen im erwerbsfähigen Alter bringen einen bereits heute spürbaren Mangel an beruflich Pflegenden mit sich.
Um eine menschenwürdige Pflege anhaltend zu gewährleisten, müssen vorhandene Ressourcen gezielter eingesetzt und zusätzliche Reserven freigelegt werden. Viele Hoffnungen liegen hier auf technologischen Innovationen. Die Digitalisierung soll das Gesundheitswesen effizienter gestalten und beispielsweise durch Künstliche Intelligenz zeitraubende Prozesse vereinfachen oder sogar automatisieren. Im Kontext der Pflege wird der Einsatz von robotischen Assistenzsystemen diskutiert.
Aus diesem Grund wurde die die Potsdamer Bürger:innenkonferenz „Robotik in der Altenpflege?“ initiiert. Um die Zukunft der Pflege gemeinsam zu gestalten, wurden 3.500 Potsdamer Bürgerinnen und Bürger kontaktiert und schließlich fünfundzwanzig Teilnehmende ausgewählt. Im Frühjahr 2024 kamen sie zusammen, um den verantwortlichen Einsatz von Robotik in der Pflege zu diskutieren.
Die hier vorliegende Erklärung ist das Ergebnis der Bürger:innenkonferenz. Sie enthält die zentralen Positionen der Teilnehmenden.
Die Bürger:innenkonferenz ist Teil des Projekts E-cARE („Ethics Guidelines for Socially Assistive Robots in Elderly Care: An Empirical-Participatory Approach“), welches die Juniorprofessur für Medizinische Ethik mit Schwerpunkt auf Digitalisierung der Fakultät für Gesundheitswissenschaften Brandenburg, Universität Potsdam, durchgeführt hat.
Das neue Hinweisgeberschutzgesetz verlangt neben der Einrichtung unternehmens- bzw. behördeneigener interner Meldestellen auch den Aufbau externer Meldestellen. Diese wurden zur Vermeidung zusätzlicher Bürokratie bei bestehenden Bundesbehörden angesiedelt. System und Wirkungsweise der externen Meldestellen sollen nachfolgend erörtert werden. Zugleich bieten die Ausführungen Anlass, gesetzgeberische Verbesserungen zu erwägen.
Carbohydrates play a vital role in all living organisms; serving as a cornerstone in primary metabolism through the release of energy from their hydrolysis and subsequent re-utilization (Apriyanto et al., 2022). Starch is the principal carbohydrate reserve in plants, providing essential energy for plant growth. Furthermore, starch serves as a significant carbohydrate source in the human diet. Beyond its nutritional value, starch has extensive industrial application associated with many aspects of human society, such as feed, pharmacy, textiles, and the production of biodegradable plastics. Understanding the mechanisms underlying starch metabolism in plants carries multifaceted benefits. Not only does it contribute to increasing crop yield and refining grain quality, but also can improve the efficiency of industrial applications.
Starch in plants is categorized into two classes based on their location and function: transitory starch and storage starch. Transitory starch is produced in chloroplasts of autotrophic tissues/organs, such as leaves. It is synthesized during the day and degraded during the night. Storage starch is synthesized in heterotrophic tissues/organs, such as endosperm, roots and tubers, which is utilized for plant reproduction and industrial application in human life. Most studies aiming to comprehend starch metabolism of Arabidopsis thaliana primarily focus on transitory starch.
Starch is stored as granular form in chloroplast and amyloplast. The parameters of starch granules, including size, morphology, and quantity per chloroplast serve as indicators of starch metabolism status. However, the understanding of their regulatory mechanism is still incomplete. In this research, I initially employed a simple and adapted method based on laser confocal scanning microscopy (LCSM) to observe size, morphology and quantity of starch granules within chloroplasts in Arabidopsis thaliana in vivo. This method facilitated a rapid and versatile analysis of starch granule parameters across numerous samples. Utilizing this approach, I compared starch granule number per chloroplast between mesophyll cells and guard cells in both wild type plants (Col-0) and several starch related mutants. The results revealed that the granule number is distinct between mesophyll cells and guard cells, even within the same genetic background, suggesting that guard cells operate a unique regulatory mechanism of starch granule number.
Subsequently, I redirected my attention toward examining starch morphology. Through microscopy analyses, I observed a gradual alteration in starch granule morphology in certain mutants during leaf aging. Specifically, in mutants such as sex1-8 and dpe2phs1ss4, there was a progressive alteration in starch granule morphology over time. Conversely, in Col-0 and ss4 mutant, these morphological alterations were not evident. This discovery suggests a new perspective to understand the development of starch morphology.
Further investigation revealed that mutants lacking either Disproportionating enzyme 2 (DPE2) or MALTOSE-EXCESS 1 (MEX1) exhibited gradual alterations in starch morphology with leaf aging. Notably, the most severe effects on starch morphology occurred in double mutants lacking either DPE2 or MEX1 in conjunction with a lack of starch synthase 4 (SS4). In these mutations, a transformation of the starch granule morphology from the typical discoid morphology to oval and eventually to a spherical shape.
To investigate the changes in the internal structure of starch during this alteration, I analyzed the chain length distribution (CLD) of the amylopectin of young, intermediate and old leaves of the mutants. Throughout starch granule development, I found an increased presence of short glucan chains within the granules, particularly evident in dpe2ss4 and mex1ss4 mutants, as well as their parental single mutants. Notably, the single mutant ss4 also showed an affected granule morphology, albeit not influenced by leaf aging..
The CLD pattern of the amylopectin reflects an integrative regulation involving several participants in starch synthesis, including starch synthases (SSs), starch branching/debranching enzymes (SBEs/DBEs). Therefore, I further detected the expression of related genes on transcription level and the enzymatic activity of their respective proteins. Results indicated altered gene expression of several regulators in these mutants, particularly demonstrating dramatic alterations in dpe2 and dpe2ss4 with leaf aging. These changes corresponded with the observed alterations in starch granule morphology.
Taken together, I have identified and characterized a progressive alteration in starch granule morphology primarily resulting from the deficiencies in DPE2 and MEX1. Furthermore, I have associated the CLD pattern with the granule morphogenesis, as well as the gene expression and enzymatic activity of proteins involved in starch synthesis. Unlike SS4, which is implicated in starch initiation, MEX1 and DPE2 are involved into starch degradation. MEX1 is located in chloroplast envelope and DPE2 is situated in the cytosol. Considering the locations and known functions of DPE2/MEX1 and SS4, I infer that there might be two pathways influencing starch morphology: an initiation-affected pathway via SS4 and a degradation-affected pathway via DPE2/MEX1.