Filtern
Erscheinungsjahr
- 2014 (189) (entfernen)
Dokumenttyp
- Wissenschaftlicher Artikel (129)
- Postprint (32)
- Dissertation (13)
- Rezension (6)
- Preprint (4)
- Habilitation (2)
- Sonstiges (2)
- Konferenzveröffentlichung (1)
Schlagworte
- anomalous diffusion (5)
- living cells (5)
- arsenolipids present (4)
- cod-liver (4)
- fatty-acids (4)
- identification (4)
- physiological consequences (4)
- visible-light (4)
- infection pathway (3)
- ionic liquids (3)
- models (3)
- polyzwitterion (3)
- synthesis (3)
- Anisotropy effect (2)
- Arenesulfonamides (2)
- Aromaticity (2)
- Chelatoaromaticity (2)
- Cycloaddition (2)
- DNA origami (2)
- DNA radiation damage (2)
- Fokker-Planck equations (2)
- G quadruplexes (2)
- Janus emulsions (2)
- RP-HPLC (2)
- TiO2 nanoparticles (2)
- Trifluoromethanesulfonamide (2)
- X-ray (2)
- absorbtion fine-structure (2)
- acinar-cells (2)
- adduct formation (2)
- atomic force microscopy (2)
- attachment (2)
- augmented-wave method (2)
- betaine (2)
- biomaterials (2)
- biomineralization (2)
- bladder-cancer (2)
- brownian-motion (2)
- carbohydrates (2)
- carcinogen exposure (2)
- cell-death (2)
- cellulose (2)
- chemoradiation therapy (2)
- chromoionophore (2)
- cockroach salivary-glands (2)
- construction (2)
- cytosine methylation (2)
- damage (2)
- diimine-complexes (2)
- dna coiling (2)
- drugs (2)
- dynamics (2)
- electron-transfer (2)
- enzyme reactions (2)
- excision-repair (2)
- excitation (2)
- excluded volume (2)
- exposure (2)
- fish (2)
- flight search patterns (2)
- fluctuation-dissipation theorem (2)
- fluorescence (2)
- fluorescence photobleaching recovery (2)
- folding kinetics (2)
- fractional dynamics approach (2)
- frameworks (2)
- gas-phase (2)
- gene-expression (2)
- gene-regulation kinetics (2)
- genomic dna methylation (2)
- graphite (2)
- green (2)
- hela-cells (2)
- human-cells (2)
- hybrid materials (2)
- hydrogen (2)
- in-vitro (2)
- indicators (2)
- induced malignant-transformation (2)
- initio molecular-dynamics (2)
- intermittent chaotic systems (2)
- intracellular na+ (2)
- ion optodes (2)
- ionische Flüssigkeiten (2)
- ionophore (2)
- langevin equation (2)
- levy flights (2)
- lifetime microscopy (2)
- low-energy electrons (2)
- manganese (2)
- marine oils (2)
- mass-spectrometry (2)
- membrane (2)
- membranes (2)
- metabolites (2)
- metathesis (2)
- methylmercury (2)
- methyltransferases dnmt3a (2)
- microporous organic polymers (2)
- mixtures (2)
- molecular rods (2)
- molecular-mechanisms (2)
- monomer (2)
- nanoclusters (2)
- nanoparticles (2)
- neurodegenerative diseases (2)
- neurotoxicity (2)
- oil (2)
- oxidation (2)
- periplaneta-americana (2)
- photon-counting statistics (2)
- photooxidation (2)
- poly(ADP-ribose) polymerase-1 (2)
- polyampholyte (2)
- polymer (2)
- polymerization (2)
- post-polymerization modification (2)
- protein binding (2)
- quantum dots (2)
- random-walks (2)
- rat (2)
- reactivity (2)
- reduction (2)
- repair (2)
- resonant formation (2)
- review (2)
- rp-hplc (2)
- ruthenium (2)
- samples (2)
- sensors (2)
- simulations (2)
- single-molecule analysis (2)
- single-particle tracking (2)
- single-strand breaks (2)
- sodium green (2)
- sorption (2)
- spatial-organization (2)
- supported gold (2)
- surface (2)
- switches (2)
- systems (2)
- tandem reaction (2)
- thimerosal (2)
- thio-dimethylarsinic acid (2)
- tight-binding (2)
- time random-walks (2)
- transition (2)
- trivalent (2)
- ventricular myocytes (2)
- vitro toxicological characterization (2)
- water (2)
- weak ergodicity breaking (2)
- zwitterionic group (2)
- (+)-Tephrodin (1)
- (Anti)aromaticity (1)
- 1,1-dimethyl-1,2,3,4-tetrahydrosiline (1)
- 1,3-Dienes (1)
- 1,5-Dienes (1)
- 3,4-dihydro-2H-pyran (1)
- 3,4-dihydro-2H-thiopyran (1)
- 3,6-Diazabicyclo[3.1.0]hexanes (1)
- 3,8-Diazabicyclo[3.2.1]octane (1)
- 3-Oxo-14 alpha, 15 alpha-epoxyschizozygine (1)
- 3D electrode structures (1)
- 4,4-dimethyl-3,4-dihydro-2H-1,4-thiasiline (1)
- 6 alpha-Hydroxy-alpha-toxicarol (1)
- Acetylpolyamine amidohydrolases (1)
- Adsorbent (1)
- Adsorption kinetic (1)
- Alkin (1)
- Allylic oxidation (1)
- Alternating polyampholytes (1)
- Antibody (1)
- Antimicrobial activities (1)
- Aromatic or quinonoid (1)
- Azid (1)
- Base pairing (1)
- Batterien (1)
- Binding assay (1)
- Binding pocket position (1)
- Biomineralisation (1)
- Biphenol (1)
- Block copolymers (1)
- Bulbine frutescens (1)
- C-13 (1)
- C-13 chemical shift difference Delta delta(C C) (1)
- Carbene ligands (1)
- Carbohydrates (1)
- Cassiamin A (1)
- Cassiamin B (1)
- Chemotaxonomy (1)
- Chromanon (1)
- Chromon (1)
- Clay-polymer nanocomposite - CPN (1)
- Click chemistry (1)
- Conformational equilibrium (1)
- Copper Metal Complexes (1)
- Copper(II) (1)
- Cross coupling (1)
- Cryo-SEM (1)
- Crystal structure (1)
- Cumarin (1)
- Cyclic GMP (1)
- Cytotoxicity (1)
- DLS (1)
- Dehnung (1)
- Dependent light scattering (1)
- Desorption (1)
- Diastereomers assignment (1)
- Dielectric properties (1)
- Dimensionsstabilität (1)
- Dimeric anthraquinone (1)
- Diterpenoid (1)
- Dodonaea angustifolia (1)
- Druck-Volumen-Änderung (1)
- Dynamic NMR (1)
- ESI-MS (1)
- ESR (1)
- Elektrostatische Wechselwirkung (1)
- Emulsification (1)
- Emulsion destabilization (1)
- Energiespeicher (1)
- Escherichia coli (1)
- F-19 (1)
- FLNS (1)
- Fabry-Perot etalon (1)
- Farbstoff (1)
- Flavanone (1)
- Flavone (1)
- Fluorescence (1)
- Fluorescence life time (1)
- Fluorescent nanoconjugate (1)
- Fluoreszens (1)
- GC-MS (1)
- Gravitation (1)
- H-1 (1)
- Hapten (1)
- Hard sphere model in the Percus-Yevick Approximation (1)
- Hemiporphyrazines (1)
- High-cell-density culture (1)
- High-resolution spectrometer (1)
- Histone deacetylases (1)
- Holzmodifikation (1)
- Homogeneous catalysis (1)
- Imidazolium (1)
- Interfacial equilibrium (1)
- Interfacial tension (1)
- Ionic Liquid (1)
- Ionic liquids (1)
- Isolations (1)
- Janus drops (1)
- Klick (1)
- Kohlenstoff (1)
- LCST (1)
- LIBS (1)
- Langmuir layers (1)
- Laser-induced breakdown spectroscopy (1)
- Lithium-Schwefel-Batterien (1)
- Magnetic properties (1)
- Magnetit Nanopartikel (1)
- Maltose-modified PEI (1)
- Mammea usambarensis (1)
- Mammea-type coumarins (1)
- Mars (1)
- Mechanical properties (1)
- Metallcarbide (1)
- Metallnitride (1)
- Metathesis (1)
- Methane (1)
- Methanogens (1)
- Michael addition (1)
- Microfluidics (1)
- Microorganism (1)
- Microparticles Reagentless assay (1)
- Micropolarity (1)
- Micropollutants (1)
- Microviscosity (1)
- Millettia dura; (1)
- Millettia leucantha (1)
- Millettia oblata ssp teitensis (1)
- Miniaturized cultivations (1)
- Molecular Probe (1)
- Monte-Carlo simulations (1)
- Multiple light scattering (1)
- Muonic molecules (1)
- N-azobenzylchitosan (1)
- N-methylnicotinamide (1)
- NMR (1)
- Nanosensor (1)
- Nanostrukturen (1)
- Naphthyridines (1)
- Network structure (1)
- Nicotinamide (1)
- Occupation quotient pi*/pi (1)
- Oligospiroketal (1)
- Optical oxygen sensor (1)
- Oxygen heterocycles (1)
- PQQ-GDH (1)
- Palladium (1)
- Paratope (1)
- Phenol (1)
- Phenylanthraquinone (1)
- Phospholipids (1)
- Plasmid DNA production (1)
- Plasmodium falciparum (1)
- Platelet (1)
- Platinum group metals (1)
- Polarization elements (1)
- Polycyclic aromatic hydrocarbons (1)
- Polymer (1)
- Polymer dispersions (1)
- Polymerized ionic liquids (1)
- Polypeptide (1)
- Polystyrene-divinylbenzene (1)
- Porphyrins (1)
- Pseudomonas aeruginosa (1)
- Push-pull alkynes (1)
- Push-pull effect (1)
- Quantum Chemical Calculations (1)
- Quantum dots (1)
- Radicals (1)
- Radikalrekombination (1)
- Raman spectroscopy (1)
- Ring-current effect (1)
- Ruthenium (1)
- Schizozygane indoline alkaloid (1)
- Schizozygia coffaeoides (1)
- Skalarprodukt von Kraft und Weg (1)
- SnAr reaction (1)
- Sol-Gel (1)
- Solid-phase extraction (1)
- Spin probes (1)
- Spinning drop (1)
- Stab (1)
- Stereochemistry (1)
- Steric hindrance (1)
- Structural investigations (1)
- Structure revision (1)
- Sub-zero temperature (Celsius) (1)
- Sulphoxide (1)
- Superkondensatoren (1)
- Supramolecular compounds (1)
- Surface exudates (1)
- Template phase (1)
- Tephrosia purpurea (1)
- Tephrosia villosa (1)
- Tetraoxo[8]circulenes (1)
- Tetraphenylethene Bioassay Fluorescent dye (1)
- Theoretical calculations (1)
- Thermal behavior (1)
- Thermoresponsive (1)
- Thiol-X (1)
- Through-space NMR shielding (TSNMRS) (1)
- ToF-SIMS (1)
- Wacker reaction (1)
- Wassergehalt (1)
- Water treatment (1)
- Wavelength modulation spectroscopy (laser spectroscopy) (1)
- Xanthone (1)
- Yukawa model in the Mean Spherical Approximation (1)
- Zwitterionen (1)
- absorption (1)
- acceptors (1)
- adenoassociated virus (1)
- adhesives (1)
- adsorption (1)
- alkine (1)
- amphiphilic polymer assembly (1)
- anti-polyelectrolyte effect (1)
- articulated (1)
- azide (1)
- azobenzenes (1)
- battery (1)
- bioanalysis (1)
- bioelectrochemistry (1)
- biosensor (1)
- biphenol (1)
- block copolymers (1)
- brewster angle microscopy (1)
- calcium phosphate (1)
- carbon (1)
- carotenoids (1)
- cations (1)
- chitosan (1)
- chlorophyll (1)
- chromanone (1)
- chromone (1)
- click (1)
- click chemistry (1)
- composites (1)
- conductive polymer (1)
- confocal raman microscopy (1)
- contrast agents (1)
- copolymers (1)
- coumarine (1)
- crosslinking (1)
- crystal structures (1)
- cyclization (1)
- cytoplasm (1)
- cytosolic sodium (1)
- de novo synthesis (1)
- degradation (1)
- density functional calculations (1)
- diffractive elements (1)
- dimensional stability (1)
- direct bioelectrocatalysis (1)
- dye (1)
- dyes/pigments (1)
- electrically switchable gratings. (1)
- electrolytes (1)
- electrostatic interaction (1)
- ellipsometry (1)
- elongation (1)
- emulsion microscopy (1)
- endosomal escape (1)
- energy storage (1)
- energy transfer (1)
- epsilon-caprolactone (1)
- escence correlation spectroscopy (1)
- escherichia-coli (1)
- europium (1)
- europium complex (1)
- excimer UV light (1)
- extraction (1)
- fluorescence correlation spectroscopy (1)
- fluorescence label (1)
- fluoroimmunoassay (1)
- food contact material (1)
- free radical polymerization (1)
- freie radikalische Polymerisation (1)
- graphene oxide (1)
- gravitation (1)
- grazing incidence X-ray diffraction (1)
- green chemistry (1)
- hemocompatibility (1)
- heterocycles (1)
- hydrophobe Moleküle (1)
- hydrophobic molecules (1)
- hydrothermal (1)
- imidazole (1)
- imidazolium (1)
- intracellular-transport (1)
- ion exchange (1)
- ionic liquid (1)
- isomerization (1)
- isotope effect (1)
- kinetic models (1)
- labels (1)
- lactate (1)
- lanthanide luminescence (1)
- laser-enhanced nuclear fusion (1)
- lichtinduziert (1)
- light induced (1)
- lipid monolayer (1)
- lithium sulfur battery (1)
- macroITO (1)
- magnetite (1)
- magnetosome (1)
- magnetotactic bacteria (1)
- magnetotaktische Bakterien (1)
- mechanical-properties (1)
- mesoporous materials (1)
- metal carbides (1)
- metal coordination (1)
- metal nitrides (1)
- microemulsions (1)
- moisture content (1)
- molecular dynamics simulations (1)
- morphology (1)
- nachhaltige Chemie (1)
- nachwachsende Rohstoffe (1)
- nano clay (1)
- nanobioconjugate (1)
- nanoparticle (1)
- nanostructures (1)
- nematic phase (1)
- onformational analysis (1)
- phenol (1)
- photochemistry (1)
- photochromism (1)
- photoinduced radical polymerization (1)
- photoswitches (1)
- pi-pi stacking (1)
- platelet aging (1)
- platelet function (1)
- platelet rich plasma (1)
- platelet storage (1)
- platform chemicals (1)
- polarization gratings (1)
- poly(epsilon-caprolactone) methacrylate (1)
- polyelectrolyte adsorption (1)
- polyesterurethane (1)
- polyesterurethanes (1)
- polymer micelles (1)
- polymer/LC composites (1)
- pressure-volume change (1)
- radical recombination (1)
- rearrangement (1)
- relaxation NMR spectroscopy (1)
- renewables (1)
- resonance energy-transfer (1)
- restricted N-S rotation (1)
- ring-opening polymerization (1)
- rod (1)
- sacrificial bonds (1)
- scalar product of force and displacement (1)
- seco-Anthraquinone (1)
- self-assembly (1)
- self-healing materials (1)
- shape-memory effect (1)
- side reaction (1)
- sol-gel (1)
- sol-gel processes (1)
- stannous octoate (1)
- statistical copolymer (1)
- structural-characterization (1)
- substituent effects (1)
- sulfobetaine (1)
- super-intense laser pulses (1)
- supercapacitors (1)
- surface charge (1)
- surface chemistry (1)
- switchable retarder (1)
- system (1)
- system-immanent forces (1)
- systemimmanente Kräfte (1)
- thermoresponsive materials (1)
- time-resolved fluorescence (1)
- trafficking (1)
- two-dimensional phases (1)
- upper critical solution temperature (1)
- visible light (1)
- whole blood (1)
- wood modification (1)
- xanthophylls (1)
- zinc (1)
Institut
- Institut für Chemie (189) (entfernen)
Picosecond X-ray absorption spectroscopy (XAS) is used to investigate the electronic and structural dynamics initiated by plasmon excitation of 1.8 nm diameter Au nanoparticles (NPs) functionalised with 1-hexanethiol. We show that 100 ps after photoexcitation the transient XAS spectrum is consistent with an 8% expansion of the Au–Au bond length and a large increase in disorder associated with melting of the NPs. Recovery of the ground state occurs with a time constant of ∼1.8 ns, arising from thermalisation with the environment. Simulations reveal that the transient spectrum exhibits no signature of charge separation at 100 ps and allows us to estimate an upper limit for the quantum yield (QY) of this process to be <0.1.
Picosecond X-ray absorption spectroscopy (XAS) is used to investigate the electronic and structural dynamics initiated by plasmon excitation of 1.8 nm diameter Au nanoparticles (NPs) functionalised with 1-hexanethiol. We show that 100 ps after photoexcitation the transient XAS spectrum is consistent with an 8% expansion of the Au–Au bond length and a large increase in disorder associated with melting of the NPs. Recovery of the ground state occurs with a time constant of ∼1.8 ns, arising from thermalisation with the environment. Simulations reveal that the transient spectrum exhibits no signature of charge separation at 100 ps and allows us to estimate an upper limit for the quantum yield (QY) of this process to be <0.1.
We study the thermal Markovian diffusion of tracer particles in a 2D medium with spatially varying diffusivity D(r), mimicking recently measured, heterogeneous maps of the apparent diffusion coefficient in biological cells. For this heterogeneous diffusion process (HDP) we analyse the mean squared displacement (MSD) of the tracer particles, the time averaged MSD, the spatial probability density function, and the first passage time dynamics from the cell boundary to the nucleus. Moreover we examine the non-ergodic properties of this process which are important for the correct physical interpretation of time averages of observables obtained from single particle tracking experiments. From extensive computer simulations of the 2D stochastic Langevin equation we present an in-depth study of this HDP. In particular, we find that the MSDs along the radial and azimuthal directions in a circular domain obey anomalous and Brownian scaling, respectively. We demonstrate that the time averaged MSD stays linear as a function of the lag time and the system thus reveals a weak ergodicity breaking. Our results will enable one to rationalise the diffusive motion of larger tracer particles such as viruses or submicron beads in biological cells.
Arsenic-containing hydrocarbons are one group of fat-soluble organic arsenic compounds (arsenolipids) found in marine fish and other seafood. A risk assessment of arsenolipids is urgently needed, but has not been possible because of the total lack of toxicological data. In this study the cellular toxicity of three arsenic-containing hydrocarbons was investigated in cultured human bladder (UROtsa) and liver (HepG2) cells. Cytotoxicity of the arsenic-containing hydrocarbons was comparable to that of arsenite, which was applied as the toxic reference arsenical. A large cellular accumulation of arsenic, as measured by ICP-MS/MS, was observed after incubation of both cell lines with the arsenolipids. Moreover, the toxic mode of action shown by the three arsenic-containing hydrocarbons seemed to differ from that observed for arsenite. Evidence suggests that the high cytotoxic potential of the lipophilic arsenicals results from a decrease in the cellular energy level. This first in vitro based risk assessment cannot exclude a risk to human health related to the presence of arsenolipids in seafood, and indicates the urgent need for further toxicity studies in experimental animals to fully assess this possible risk.
Arsenic-containing hydrocarbons are one group of fat-soluble organic arsenic compounds (arsenolipids) found in marine fish and other seafood. A risk assessment of arsenolipids is urgently needed, but has not been possible because of the total lack of toxicological data. In this study the cellular toxicity of three arsenic-containing hydrocarbons was investigated in cultured human bladder (UROtsa) and liver (HepG2) cells. Cytotoxicity of the arsenic-containing hydrocarbons was comparable to that of arsenite, which was applied as the toxic reference arsenical. A large cellular accumulation of arsenic, as measured by ICP-MS/MS, was observed after incubation of both cell lines with the arsenolipids. Moreover, the toxic mode of action shown by the three arsenic-containing hydrocarbons seemed to differ from that observed for arsenite. Evidence suggests that the high cytotoxic potential of the lipophilic arsenicals results from a decrease in the cellular energy level. This first in vitro based risk assessment cannot exclude a risk to human health related to the presence of arsenolipids in seafood, and indicates the urgent need for further toxicity studies in experimental animals to fully assess this possible risk.
This study aims to further mechanistically understand toxic modes of action after chronic inorganic arsenic exposure. Therefore long-term incubation studies in cultured cells were carried out, to display chronically attained changes, which cannot be observed in the generally applied in vitro short-term incubation studies. Particularly, the cytotoxic, genotoxic and epigenetic effects of an up to 21 days incubation of human urothelial (UROtsa) cells with pico- to nanomolar concentrations of iAsIII and its metabolite thio-DMAV were compared. After 21 days of incubation, cytotoxic effects were strongly enhanced in the case of iAsIII and might partly be due to glutathione depletion and genotoxic effects on the chromosomal level. These results are in strong contrast to cells exposed to thio-DMAV. Thus, cells seemed to be able to adapt to this arsenical, as indicated among others by an increase in the cellular glutathione level. Most interestingly, picomolar concentrations of both iAsIII and thio-DMAV caused global DNA hypomethylation in UROtsa cells, which was quantified in parallel by 5-medC immunostaining and a newly established, reliable, high resolution mass spectrometry (HRMS)-based test system. This is the first time that epigenetic effects are reported for thio-DMAV; iAsIII induced epigenetic effects occur in at least 8000 fold lower concentrations as reported in vitro before. The fact that both arsenicals cause DNA hypomethylation at really low, exposure-relevant concentrations in human urothelial cells suggests that this epigenetic effect might contribute to inorganic arsenic induced carcinogenicity, which for sure has to be further investigated in future studies.
This study aims to further mechanistically understand toxic modes of action after chronic inorganic arsenic exposure. Therefore long-term incubation studies in cultured cells were carried out, to display chronically attained changes, which cannot be observed in the generally applied in vitro short-term incubation studies. Particularly, the cytotoxic, genotoxic and epigenetic effects of an up to 21 days incubation of human urothelial (UROtsa) cells with pico- to nanomolar concentrations of iAsIII and its metabolite thio-DMAV were compared. After 21 days of incubation, cytotoxic effects were strongly enhanced in the case of iAsIII and might partly be due to glutathione depletion and genotoxic effects on the chromosomal level. These results are in strong contrast to cells exposed to thio-DMAV. Thus, cells seemed to be able to adapt to this arsenical, as indicated among others by an increase in the cellular glutathione level. Most interestingly, picomolar concentrations of both iAsIII and thio-DMAV caused global DNA hypomethylation in UROtsa cells, which was quantified in parallel by 5-medC immunostaining and a newly established, reliable, high resolution mass spectrometry (HRMS)-based test system. This is the first time that epigenetic effects are reported for thio-DMAV; iAsIII induced epigenetic effects occur in at least 8000 fold lower concentrations as reported in vitro before. The fact that both arsenicals cause DNA hypomethylation at really low, exposure-relevant concentrations in human urothelial cells suggests that this epigenetic effect might contribute to inorganic arsenic induced carcinogenicity, which for sure has to be further investigated in future studies.
We study the diffusion of a tracer particle, which moves in continuum space between a lattice of excluded volume, immobile non-inert obstacles. In particular, we analyse how the strength of the tracer–obstacle interactions and the volume occupancy of the crowders alter the diffusive motion of the tracer. From the details of partitioning of the tracer diffusion modes between trapping states when bound to obstacles and bulk diffusion, we examine the degree of localisation of the tracer in the lattice of crowders. We study the properties of the tracer diffusion in terms of the ensemble and time averaged mean squared displacements, the trapping time distributions, the amplitude variation of the time averaged mean squared displacements, and the non-Gaussianity parameter of the diffusing tracer. We conclude that tracer–obstacle adsorption and binding triggers a transient anomalous diffusion. From a very narrow spread of recorded individual time averaged trajectories we exclude continuous type random walk processes as the underlying physical model of the tracer diffusion in our system. For moderate tracer–crowder attraction the motion is found to be fully ergodic, while at stronger attraction strength a transient disparity between ensemble and time averaged mean squared displacements occurs. We also put our results into perspective with findings from experimental single-particle tracking and simulations of the diffusion of tagged tracers in dense crowded suspensions. Our results have implications for the diffusion, transport, and spreading of chemical components in highly crowded environments inside living cells and other structured liquids.
We study the diffusion of a tracer particle, which moves in continuum space between a lattice of excluded volume, immobile non-inert obstacles. In particular, we analyse how the strength of the tracer–obstacle interactions and the volume occupancy of the crowders alter the diffusive motion of the tracer. From the details of partitioning of the tracer diffusion modes between trapping states when bound to obstacles and bulk diffusion, we examine the degree of localisation of the tracer in the lattice of crowders. We study the properties of the tracer diffusion in terms of the ensemble and time averaged mean squared displacements, the trapping time distributions, the amplitude variation of the time averaged mean squared displacements, and the non-Gaussianity parameter of the diffusing tracer. We conclude that tracer–obstacle adsorption and binding triggers a transient anomalous diffusion. From a very narrow spread of recorded individual time averaged trajectories we exclude continuous type random walk processes as the underlying physical model of the tracer diffusion in our system. For moderate tracer–crowder attraction the motion is found to be fully ergodic, while at stronger attraction strength a transient disparity between ensemble and time averaged mean squared displacements occurs. We also put our results into perspective with findings from experimental single-particle tracking and simulations of the diffusion of tagged tracers in dense crowded suspensions. Our results have implications for the diffusion, transport, and spreading of chemical components in highly crowded environments inside living cells and other structured liquids.