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Answer Set Programming (ASP) is a well-known paradigm of declarative programming with roots in logic programming and non-monotonic reasoning. Similar to other closely related problemsolving technologies, such as SAT/SMT, QBF, Planning and Scheduling, advancements in ASP solving are assessed in competition events. In this paper, we report about the design and results of the Sixth ASP Competition, which was jointly organized by the University of Calabria (Italy), Aalto University (Finland), and the University of Genoa (Italy), in affiliation with the 13th International Conference on Logic Programming and Non-Monotonic Reasoning. This edition maintained some of the design decisions introduced in 2014, e.g., the conception of sub-tracks, the scoring scheme,and the adherence to a fixed modeling language in order to push the adoption of the ASP-Core-2 standard. On the other hand, it featured also some novelties, like a benchmark selection stage classifying instances according to their empirical hardness, and a “Marathon” track where the topperforming systems are given more time for solving hard benchmarks.
Controlling mesenchymal stem cells (MSCs) behavior is necessary to fully exploit their therapeutic potential. Various approaches are employed to effectively influence the migration capacity of MSCs. Here, topographic microstructures with different microscale roughness were created on polystyrene (PS) culture vessel surfaces as a feasible physical preconditioning strategy to modulate MSC migration. By analyzing trajectories of cells migrating after reseeding, we demonstrated that the mobilization velocity of human adipose derived mesenchymal stem cells (hADSCs) could be promoted by and persisted after brief preconditioning with the appropriate microtopography. Moreover, the elevated activation levels of focal adhesion kinase (FAK) and mitogen-activated protein kinase (MAPK) in hADSCs were also observed during and after the preconditioning process. These findings underline the potential enhancement of in vivo therapeutic efficacy in regenerative medicine via transplantation of topographic microstructure preconditioned stem cells.
Der Band versammelt 21 Beiträge, die unter dem Titel "Technische Bildung und berufliche Orientierung im Wandel" aus Anlass der Emeritierung von Prof. Dr. paed. habil Bernd Meier, Professur für Technologie und Berufliche Orientierung an der Wirtschafts- und Sozialwissenschaftlichen Fakultät der Universität Potsdam, auf einem Kolloquium 2017 gehalten wurden.
Imagines
(2017)
This series seeks to broaden the scholarly community’s understanding of the reception of classical antiquity in the visual and performing arts. A particular focus will be drawn on the 20th and 21st centuries and on media that have been traditionally neglected because considered “commercial” and/or “popular”, such as comics, advertising, digital media, design, fashion, and theme parks. It challenges traditional, and still very widespread, assumptions that distinguish “high” from “popular” culture, but also demonstrates the indisputable importance that classical antiquity enjoys in the modern and postmodern world, and all across the planet, carefully looking at forms of Classical Receptions outside the “traditional” regions object of such studies. Through a consistent shift from the traditional, academic approach, the series is the product of a continuous dialogue between scholars on the one side, and “producers” of classical reception – painters, sculptors, photographs, architects, designers, etc. –on the other, who write about their mechanisms of appropriation of the Ancient world . Each book highlights the popularity of antiquity today and reveals the forms and mechanisms of its reception. The series thus explains the choice of subjects and motives, the elaboration and re-mediatization processes taking place in the creative act, as well as the complexity of the “reception chains”, which make it today impossible, for instance, to visualize the ancient world without the filter of historical movies.
During the second phase of the Alpine Fault, Deep Fault Drilling Project (DFDP) in the Whataroa River, South Westland, New Zealand, bedrock was encountered in the DFDP-2B borehole from 238.5–893.2 m Measured Depth (MD). Continuous sampling and meso- to microscale characterisation of whole rock cuttings established that, in sequence, the borehole sampled amphibolite facies, Torlesse Composite Terrane-derived schists, protomylonites and mylonites, terminating 200–400 m above an Alpine Fault Principal Slip Zone (PSZ) with a maximum dip of 62°. The most diagnostic structural features of increasing PSZ proximity were the occurrence of shear bands and reduction in mean quartz grain sizes. A change in composition to greater mica:quartz + feldspar, most markedly below c. 700 m MD, is inferred to result from either heterogeneous sampling or a change in lithology related to alteration. Major oxide variations suggest the fault-proximal Alpine Fault alteration zone, as previously defined in DFDP-1 core, was not sampled.
Background/Aims:
Obesity is a main risk factor for the development of hepatic insulin resistance and it is accompanied by adipocyte hypertrophy and an elevated expression of different adipokines such as autotaxin (ATX). ATX converts lysophosphatidylcholine to lysophosphatidic acid (LPA) and acts as the main producer of extracellular LPA. This bioactive lipid regulates a broad range of physiological and pathological responses by activation of LPA receptors (LPA1-6).
Methods:
The activation of phosphatidylinositide 3-kinases (PI3K) signaling (Akt and GSK-3ß) was analyzed via western blotting in primary rat hepatocytes. Incorporation of glucose into glycogen was measured by using radio labeled glucose. Real-time PCR analysis and pharmacological modulation of LPA receptors were performed. Human plasma LPA levels of obese (BMI > 30, n = 18) and normal weight individuals (BMI 18.5-25, n = 14) were analyzed by liquid chromatography tandem-mass spectrometry (LC-MS/MS).
Results:
Pretreatment of primary hepatocytes with LPA resulted in an inhibition of insulin-mediated Gck expression, PI3K activation and glycogen synthesis. Pharmacological approaches revealed that the LPA3-receptor subtype is responsible for the inhibitory effect of LPA on insulin signaling. Moreover, human plasma LPA concentrations (16: 0 LPA) of obese participants (BMI > 30) are significantly elevated in comparison to normal weight individuals (BMI 18.5-25).
Conclusion:
LPA is able to interrupt insulin signaling in primary rat hepatocytes via the LPA3 receptor subtype. Moreover, the bioactive lipid LPA (16: 0) is increased in obesity.
Surface acoustic wave (SAW) devices are well-known for gravimetric sensor applications. In biosensing applications, chemical-and biochemically evoked adsorption processes at surfaces are detected in liquid environments using delay-line or resonator sensor configurations, preferably in combination with appropriate microfluidic devices. In this paper, a novel SAW-based impedance sensor type is introduced which uses only one interdigital electrode transducer (IDT) simultaneously as SAW generator and sensor element. It is shown that the amplitude of the reflected S-11 signal directly depends on the input impedance of the SAW device. The input impedance is strongly influenced by mass adsorption which causes a characteristic and measurable impedance mismatch.
Bullying ist eine Form wiederholten, aggressiven Verhaltens mit ernstzunehmenden Auswirkungen, unter denen Täter und Opfer häufig lange nach Ende des Bullying-Geschehens leiden. Dennoch ist die Therapie von Bullying und den damit einhergehenden Folgen ein bisher in der Forschung vernachlässigtes Thema. Im Rahmen eines systematischen Literaturüberblicks wurde daher untersucht, welche Therapieformen zur Behandlung von Bullying und dessen Folgen bei Opfern und bei Tätern bereits angewendet wurden. Eine systematische Suche in nationalen und internationalen Datenbanken führte zu 31 relevanten Publikationen, in denen 34 therapeutische Interventionen aus über 14 Ländern beschrieben wurden. In zehn Therapiestudien mit kontrolliertem Design zeigte sich, dass Behandlungsangebote, die sich sowohl an die betroffenen Personen als auch an ihr soziales Umfeld richten, besonders effektiv in der Behandlung von Bullying-Folgen sind. Die restlichen 24 Behandlungsansätze wurden keiner kontrollierten Evaluation unterzogen. Insgesamt zwei Drittel aller therapeutischen Interventionen wenden sich an die Gruppe der Opfer. Hier wird im Unterschied zur Behandlung von Tätern verstärkt auf Gruppentherapien zurückgegriffen. Unter der Bandbreite an Ansätzen ist die kognitive Verhaltenstherapie am häufigsten vertreten. Festzustellen bleibt ein Forschungsmangel an evidenzbasierten, gezielten Interventionen zur Behandlung von Bullying und dessen Folgen bei Opfern und Tätern. Unseres Wissens stellt diese Arbeit den ersten systematischen Überblick zu therapeutischen Interventionen bei Bullying für Kinder und Jugendliche dar.
In this paper, the applicability of deep downhole geoelectrical monitoring for detecting CO2 related signatures is evaluated after a nearly ten year period of CO2 storage at the Ketzin pilot site. Deep downhole electrode arrays have been studied as part of a multi-physical monitoring concept at four CO2 pilot test sites worldwide so far. For these sites, it was considered important to implement the geoelectrical method into the measurement program of tracking the CO2 plume. Analyzing the example of the Ketzin site, it can be seen that during all phases of the CO2 storage reservoir development the resistivity measurements and their corresponding tomographic interpretation contribute in a beneficial manner to the measurement, monitoring and verification (MMV) protocol. The most important impact of a permanent electrode array is its potential as tool for estimating reservoir saturations.
CPS and the Worker
(2017)
The idea of interlinked, sensor-augmented, self-governing Cyber Physical System (CPS) production processes is gaining momentum. At the same time, the impact of this concept on the workforce remains surprisingly vague. This can be explained by the fact that man is not at the centre of these developments and—even more importantly—automation is geared towards eliminating human activity. Based on the first views in the 1980s, the label of the “process worker” assumed an almost exclusive focus on control and maintenance tasks for this new type of worker in the automated factory. Recent experiences show, however, that as long as robots are not self-learning, man will be the template for these machines and we can already notice the emerging parallelism of fully automated production lines and human workshops. The changing nature of the workforce will gain further momentum if one depicts new, open formats of production. Here, the worker will have to assume new roles in reconfiguring the production processes.