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Abdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices to complement body mass index (BMI) when assessing all-cause mortality. We used data from 352,985 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) and Cox proportional hazards models adjusted for other risk factors. During a mean follow-up of 16.1 years, 38,178 participants died. Combining in one model BMI and a strongly correlated waist index altered the association patterns with mortality, to a predominantly negative association for BMI and a stronger positive association for the waist index, while combining BMI with the uncorrelated A Body Shape Index (ABSI) preserved the association patterns. Sex-specific cohort-wide quartiles of waist indices correlated with BMI could not separate high-risk from low-risk individuals within underweight (BMI<18.5 kg/m(2)) or obese (BMI30 kg/m(2)) categories, while the highest quartile of ABSI separated 18-39% of the individuals within each BMI category, which had 22-55% higher risk of death. In conclusion, only a waist index independent of BMI by design, such as ABSI, complements BMI and enables efficient risk stratification, which could facilitate personalisation of screening, treatment and monitoring.
We propose a reduced dynamical system describing the coupled evolution of fluid flow and magnetic field at the top of the Earth's core between the years 1900 and 2014. The flow evolution is modeled with a first-order autoregressive process, while the magnetic field obeys the classical frozen flux equation. An ensemble Kalman filter algorithm serves to constrain the dynamics with the geomagnetic field and its secular variation given by the COV-OBS.x1 model. Using a large ensemble with 40,000 members provides meaningful statistics including reliable error estimates. The model highlights two distinct flow scales. Slowly varying large-scale elements include the already documented eccentric gyre. Localized short-lived structures include distinctly ageostophic features like the high-latitude polar jet on the Northern Hemisphere. Comparisons with independent observations of the length-of-day variations not only validate the flow estimates but also suggest an acceleration of the geostrophic flows over the last century. Hindcasting tests show that our model outperforms simpler predictions bases (linear extrapolation and stationary flow). The predictability limit, of about 2,000 years for the magnetic dipole component, is mostly determined by the random fast varying dynamics of the flow and much less by the geomagnetic data quality or lack of small-scale information.